Knowledge (XXG)

GPLD1

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242: 219: 116: 141: 507: 493: 500: 248: 147: 1954: 1655:
Slomiany A, Nishikawa H, Slomiany BL (March 2002). "Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa".
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Jaworek J, Bonio J, Leja-Szpa A, Nawrot K, Tomaszewska MR, Stachura J, et al. (March 2002). "Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin".
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Scallon BJ, Fung WJ, Tsang TC, Li S, Kado-Fong H, Huang KS, Kochan JP (April 1991). "Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D".
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Kurtz TA, Fineberg NS, Considine RV, Deeg MA (February 2004). "Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D".
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Deeg MA, Bowen RF (2002). "Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D".
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Magnusson P, Sharp CA, Farley JR (November 2002). "Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts".
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Schofield JN, Rademacher TW (November 2000). "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene".
1465:"Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins" 2023: 1999: 1727:
Xiaotong H, Hannocks MJ, Hampson I, Brunner G (2002). "GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy".
1258: 1142:(GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by the GPLD1 gene is a GPI degrading enzyme that 1240: 2018: 1911:"Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells" 1872:
Everett PB, Senogles SE (November 2004). "D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway".
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Lugli EB, Pouliot M, Portela M, Loomis MR, Raper J (November 2004). "Characterization of primate trypanosome lytic factors".
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Jinnai H, Nakamura S (August 1999). "Characterization of phospholipase D activation by GM2 activator in a cell-free system".
1223: 140: 115: 1202: 1139: 57: 1170: 254: 153: 247: 146: 1992: 905: 65: 1157:
Plasma concentrations of Gpld1 in mice were found to increase after exercise and to correlate with improved
886: 1399: 1330:"Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain" 1985: 1507: 1341: 1147: 129: 44: 1897: 1752: 1375: 1158: 89: 1026: 1000: 979: 975: 1932: 1889: 1860: 1831: 1802: 1781: 1744: 1715: 1686: 1665: 1643: 1622: 1587: 1566: 1535:
Metz CN, Brunner G, Choi-Muira NH, Nguyen H, Gabrilove J, Caras IW, et al. (April 1994).
1523: 1486: 1440: 1367: 1293: 1174: 506: 492: 37: 1969: 1537:"Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D" 1328:
Horowitz AM, Fan X, Bieri G, Smith LK, Sanchez-Diaz CI, Schroer AB, et al. (July 2020).
1922: 1881: 1852: 1823: 1773: 1736: 1707: 1612: 1556: 1548: 1515: 1476: 1430: 1357: 1349: 1285: 334: 265: 209: 164: 1795:
Hunan Yi Ke da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
1636:
Hunan Yi Ke da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
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positive regulation of insulin secretion involved in cellular response to glucose stimulus
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Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a
1601:"GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex" 1511: 1419:"GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex" 1345: 48:, GPIPLD, GPIPLDM, PIGPLD, PIPLD, glycosylphosphatidylinositol specific phospholipase D1 1552: 1481: 1464: 1362: 1329: 1777: 1617: 1600: 1561: 1536: 1435: 1418: 1289: 775: 770: 765: 760: 755: 750: 745: 740: 735: 730: 725: 720: 715: 710: 705: 700: 695: 690: 685: 680: 675: 670: 665: 660: 655: 650: 645: 640: 635: 630: 614: 609: 604: 599: 594: 589: 584: 579: 563: 558: 553: 548: 2012: 1856: 1395:"An Enzyme That Increases With Exercise Can Improve Memory In Mice, And Maybe People" 1379: 535: 1909:
Mead KI, Zheng Y, Manzotti CN, Perry LC, Liu MK, Burke F, et al. (April 2005).
1901: 1965: 1756: 327: 106: 69: 1827: 1885: 93: 1927: 1910: 1263:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
1161:, and concentrations of GPLD1 in blood were increased in active elderly humans. 410: 1740: 1143: 226: 123: 73: 1519: 1353: 805: 470: 348: 293: 280: 192: 179: 81: 1936: 1893: 1864: 1835: 1806: 1785: 1748: 1719: 1690: 1669: 1647: 1626: 1591: 1444: 1371: 1315:"Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1" 1297: 1570: 1527: 1490: 1109: 1104: 1093: 950: 931: 917: 872: 1125: 1077: 827: 1953: 1711: 1278:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
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positive regulation of high-density lipoprotein particle clearance
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Clinica Chimica Acta; International Journal of Clinical Chemistry
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positive regulation of membrane protein ectodomain proteolysis
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glycans, thereby releasing the attached protein from the
641:
positive regulation of triglyceride biosynthetic process
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the inositol phosphate linkage in proteins anchored by
761:
negative regulation of triglyceride catabolic process
559:
glycosylphosphatidylinositol phospholipase D activity
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Phosphatidylinositol-glycan-specific phospholipase D
771:
negative regulation of cell population proliferation
736:
positive regulation of alkaline phosphatase activity
1040: 1019: 993: 968: 731:
regulation of cellular response to insulin stimulus
1219: 1217: 1215: 1198: 1196: 1194: 706:positive regulation of endothelial cell migration 696:cell migration involved in sprouting angiogenesis 264: 163: 676:positive regulation of glucose metabolic process 666:hematopoietic stem cell migration to bone marrow 16:Protein-coding gene in the species Homo sapiens 1412: 1410: 1224:GRCm38: Ensembl release 89: ENSMUSG00000021340 746:complement receptor mediated signaling pathway 1993: 1599:Deeg MA, Bierman EL, Cheung MC (March 2001). 1417:Deeg MA, Bierman EL, Cheung MC (March 2001). 8: 1793:Tang JH, Gu SL, Zhang XJ (April 2001). "". 1203:GRCh38: Ensembl release 89: ENSG00000112293 2000: 1986: 801: 531: 437:transitional epithelium of urinary bladder 305: 204: 101: 1926: 1616: 1560: 1480: 1434: 1361: 1309: 1307: 751:positive regulation of apoptotic process 585:intracellular membrane-bounded organelle 1190: 449:paraventricular nucleus of hypothalamus 1845:Molecular and Biochemical Parasitology 1729:Clinical & Experimental Metastasis 1679:Journal of Physiology and Pharmacology 1658:Journal of Physiology and Pharmacology 18: 766:phosphatidylcholine metabolic process 741:cellular response to insulin stimulus 269: 230: 225: 168: 127: 122: 7: 1950: 1948: 1580:The Kobe Journal of Medical Sciences 1463:Hoener MC, Brodbeck U (June 1992). 1972:. You can help Knowledge (XXG) by 1553:10.1002/j.1460-2075.1994.tb06438.x 1482:10.1111/j.1432-1033.1992.tb16981.x 1037: 1016: 990: 965: 941: 922: 896: 877: 851: 832: 636:insulin receptor signaling pathway 590:intracellular anatomical structure 487: 405: 343: 322: 14: 1128:that in humans is encoded by the 681:hematopoietic stem cell migration 661:cellular response to triglyceride 549:sodium channel regulator activity 1952: 1857:10.1016/j.molbiopara.2004.07.004 1469:European Journal of Biochemistry 726:positive regulation of secretion 716:positive regulation of cytolysis 691:cellular response to cholesterol 631:cellular response to calcium ion 505: 498: 491: 457:lumbar subsegment of spinal cord 433:dorsomedial hypothalamic nucleus 253: 246: 240: 217: 152: 145: 139: 114: 516:More reference expression data 471:More reference expression data 379:right hemisphere of cerebellum 1: 2024:Human chromosome 6 gene stubs 1828:10.1016/j.metabol.2003.09.004 1778:10.1016/S0009-8981(02)00248-6 1700:Biochemistry and Cell Biology 1618:10.1016/S0022-2275(20)31669-2 1436:10.1016/S0022-2275(20)31669-2 1290:10.1016/s0167-4781(00)00194-9 776:C-terminal protein lipidation 238: 137: 1886:10.1016/j.neulet.2004.08.033 1140:glycosylphosphatidylinositol 2019:Genes on human chromosome 6 1928:10.4049/jimmunol.174.8.4803 651:chondrocyte differentiation 2040: 1947: 1634:Tang J, Li W (2002). "". 1605:Journal of Lipid Research 1423:Journal of Lipid Research 1259:"Mouse PubMed Reference:" 1241:"Human PubMed Reference:" 1108: 1103: 1099: 1092: 1076: 1057: 1044: 1023: 1012: 997: 972: 961: 948: 944: 929: 925: 916: 903: 899: 884: 880: 871: 858: 854: 839: 835: 826: 811: 804: 800: 784: 701:transepithelial transport 534: 530: 513: 490: 481: 468: 417: 408: 395:Descending thoracic aorta 355: 346: 316: 308: 304: 287: 274: 237: 216: 207: 203: 186: 173: 136: 113: 104: 100: 55: 52: 42: 35: 30: 26: 21: 1393:Harris R (9 June 2020). 1169:GPLD1 has been shown to 1070:Chr 13: 25.13 – 25.18 Mb 554:phospholipase D activity 429:dorsal tegmental nucleus 271:13 A3.1|13 10.79 cM 1741:10.1023/A:1015545407700 1520:10.1126/science.2017684 1354:10.1126/science.aaw2622 721:cellular response to pH 1063:Chr 6: 24.42 – 24.5 Mb 1915:Journal of Immunology 1400:National Public Radio 600:extracellular exosome 232:Chromosome 13 (mouse) 1874:Neuroscience Letters 1148:phosphatidylinositol 615:extracellular matrix 605:extracellular region 130:Chromosome 6 (human) 1512:1991Sci...252..446S 1346:2020Sci...369..167H 686:response to glucose 610:extracellular space 375:right lobe of liver 1960:This article on a 1159:cognitive function 906:ENSMUSG00000021340 711:GPI anchor release 624:Biological process 595:lysosomal membrane 573:Cellular component 564:hydrolase activity 542:Molecular function 421:left lobe of liver 371:buccal mucosa cell 1981: 1980: 1340:(6500): 167–173. 1175:Apolipoprotein A1 1119: 1118: 1115: 1114: 1088: 1087: 1053: 1052: 1034: 1033: 1008: 1007: 987: 986: 957: 956: 938: 937: 912: 911: 893: 892: 867: 866: 848: 847: 796: 795: 526: 525: 522: 521: 477: 476: 464: 463: 402: 401: 300: 299: 199: 198: 94:GPLD1 - orthologs 2031: 2002: 1995: 1988: 1956: 1949: 1940: 1930: 1905: 1868: 1839: 1810: 1789: 1760: 1723: 1694: 1673: 1651: 1630: 1620: 1595: 1574: 1564: 1541:The EMBO Journal 1531: 1494: 1484: 1449: 1448: 1438: 1414: 1405: 1404: 1390: 1384: 1383: 1365: 1325: 1319: 1318: 1311: 1302: 1301: 1273: 1267: 1266: 1255: 1249: 1248: 1237: 1231: 1221: 1210: 1200: 1101: 1100: 1072: 1065: 1048: 1038: 1029: 1017: 1013:RefSeq (protein) 1003: 991: 982: 966: 942: 923: 897: 878: 852: 833: 802: 532: 518: 509: 502: 495: 488: 473: 413: 411:Top expressed in 406: 359:secondary oocyte 351: 349:Top expressed in 344: 323: 306: 296: 283: 272: 257: 250: 244: 233: 221: 205: 195: 182: 171: 156: 149: 143: 132: 118: 102: 96: 47: 40: 19: 2039: 2038: 2034: 2033: 2032: 2030: 2029: 2028: 2009: 2008: 2007: 2006: 1945: 1943: 1908: 1871: 1842: 1813: 1792: 1763: 1726: 1712:10.1139/o02-004 1697: 1676: 1654: 1633: 1598: 1586:(3–4): 181–90. 1577: 1534: 1506:(5004): 446–8. 1497: 1462: 1458: 1456:Further reading 1453: 1452: 1416: 1415: 1408: 1392: 1391: 1387: 1327: 1326: 1322: 1313: 1312: 1305: 1284:(1–2): 189–94. 1275: 1274: 1270: 1257: 1256: 1252: 1239: 1238: 1234: 1222: 1213: 1201: 1192: 1187: 1167: 1152:plasma membrane 1110:View/Edit Mouse 1105:View/Edit Human 1068: 1061: 1058:Location (UCSC) 1046: 1025: 999: 978: 974: 887:ENSG00000112293 780: 619: 568: 514: 504: 503: 497: 496: 469: 460: 455: 451: 447: 445:arcuate nucleus 443: 441:mammillary body 439: 435: 431: 427: 423: 409: 398: 393: 389: 385: 381: 377: 373: 369: 365: 361: 347: 291: 278: 270: 260: 259: 258: 251: 231: 208:Gene location ( 190: 177: 169: 159: 158: 157: 150: 128: 105:Gene location ( 56: 43: 36: 17: 12: 11: 5: 2037: 2035: 2027: 2026: 2021: 2011: 2010: 2005: 2004: 1997: 1990: 1982: 1979: 1978: 1957: 1942: 1941: 1921:(8): 4803–11. 1906: 1869: 1840: 1811: 1790: 1772:(1–2): 59–70. 1761: 1724: 1695: 1674: 1652: 1631: 1596: 1575: 1547:(7): 1741–51. 1532: 1495: 1459: 1457: 1454: 1451: 1450: 1406: 1385: 1320: 1303: 1268: 1250: 1232: 1211: 1189: 1188: 1186: 1183: 1166: 1163: 1117: 1116: 1113: 1112: 1107: 1097: 1096: 1090: 1089: 1086: 1085: 1083: 1081: 1074: 1073: 1066: 1059: 1055: 1054: 1051: 1050: 1042: 1041: 1035: 1032: 1031: 1021: 1020: 1014: 1010: 1009: 1006: 1005: 995: 994: 988: 985: 984: 970: 969: 963: 959: 958: 955: 954: 946: 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1442: 1437: 1432: 1429:(3): 442–51. 1428: 1424: 1420: 1413: 1411: 1407: 1402: 1401: 1396: 1389: 1386: 1381: 1377: 1373: 1369: 1364: 1359: 1355: 1351: 1347: 1343: 1339: 1335: 1331: 1324: 1321: 1316: 1310: 1308: 1304: 1299: 1295: 1291: 1287: 1283: 1279: 1272: 1269: 1264: 1260: 1254: 1251: 1246: 1242: 1236: 1233: 1229: 1225: 1220: 1218: 1216: 1212: 1208: 1204: 1199: 1197: 1195: 1191: 1184: 1182: 1180: 1176: 1172: 1164: 1162: 1160: 1155: 1153: 1149: 1145: 1141: 1136: 1134: 1131: 1127: 1123: 1111: 1106: 1102: 1098: 1095: 1091: 1084: 1082: 1079: 1075: 1071: 1067: 1064: 1060: 1056: 1049: 1043: 1039: 1036: 1030: 1028: 1022: 1018: 1015: 1011: 1004: 1002: 996: 992: 989: 983: 981: 977: 971: 967: 964: 962:RefSeq (mRNA) 960: 953: 952: 947: 943: 940: 934: 933: 928: 924: 921: 919: 915: 908: 907: 902: 898: 895: 889: 888: 883: 879: 876: 874: 870: 863: 862: 857: 853: 850: 844: 843: 838: 834: 831: 829: 825: 822: 819: 817: 814: 810: 807: 803: 799: 792: 788: 783: 777: 774: 772: 769: 767: 764: 762: 759: 757: 754: 752: 749: 747: 744: 742: 739: 737: 734: 732: 729: 727: 724: 722: 719: 717: 714: 712: 709: 707: 704: 702: 699: 697: 694: 692: 689: 687: 684: 682: 679: 677: 674: 672: 669: 667: 664: 662: 659: 657: 654: 652: 649: 647: 644: 642: 639: 637: 634: 632: 629: 628: 626: 623: 622: 616: 613: 611: 608: 606: 603: 601: 598: 596: 593: 591: 588: 586: 583: 581: 578: 577: 575: 572: 571: 565: 562: 560: 557: 555: 552: 550: 547: 546: 544: 541: 540: 537: 536:Gene ontology 533: 529: 517: 512: 508: 501: 494: 489: 486: 484: 480: 472: 467: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 419: 416: 412: 407: 404: 394: 390: 386: 383:skin of thigh 382: 378: 374: 370: 366: 362: 358: 357: 354: 350: 345: 342: 341: 338: 336: 332: 330: 329: 325: 324: 321: 319: 315: 311: 307: 303: 295: 290: 286: 282: 277: 267: 263: 256: 249: 243: 236: 228: 224: 220: 215: 211: 206: 202: 194: 189: 185: 181: 176: 166: 162: 155: 148: 142: 135: 131: 125: 121: 117: 112: 108: 103: 99: 95: 91: 87: 83: 79: 75: 71: 67: 63: 59: 51: 46: 39: 34: 29: 25: 20: 1974:expanding it 1966:chromosome 6 1959: 1944: 1918: 1914: 1877: 1873: 1848: 1844: 1822:(2): 138–9. 1819: 1815: 1798: 1794: 1769: 1765: 1735:(4): 291–9. 1732: 1728: 1703: 1699: 1685:(1): 51–74. 1682: 1678: 1664:(1): 21–38. 1661: 1657: 1639: 1635: 1608: 1604: 1583: 1579: 1544: 1540: 1503: 1499: 1472: 1468: 1426: 1422: 1398: 1388: 1337: 1333: 1323: 1281: 1277: 1271: 1262: 1253: 1244: 1235: 1168: 1165:Interactions 1156: 1137: 1129: 1121: 1120: 1045: 1024: 998: 973: 949: 930: 904: 885: 859: 840: 820: 815: 656:ossification 333: 326: 53:External IDs 1880:(1): 34–9. 1851:(1): 9–20. 1801:(2): 95–7. 363:human penis 292:25,176,484 279:25,127,135 191:24,495,205 178:24,424,565 31:Identifiers 2013:Categories 1816:Metabolism 1230:, May 2017 1209:, May 2017 1185:References 1144:hydrolyzes 337:(ortholog) 74:HomoloGene 1964:on human 1380:220428681 1027:NP_001494 1001:NM_008156 980:NM_177483 976:NM_001503 806:Orthologs 580:cytoplasm 453:esophagus 82:GeneCards 1937:15814706 1902:27173449 1894:15500962 1865:15500911 1836:14767861 1807:12536633 1786:12367767 1749:12090469 1720:11989719 1691:11939719 1670:11939716 1648:11938765 1627:11254757 1592:10752311 1445:11254757 1372:32646997 1298:11072085 1226:– 1205:– 1171:interact 1094:Wikidata 785:Sources: 387:testicle 1757:2868010 1571:7512501 1528:2017684 1508:Bibcode 1500:Science 1491:1606959 1363:7879650 1342:Bibcode 1334:Science 1228:Ensembl 1207:Ensembl 918:UniProt 873:Ensembl 812:Species 791:QuickGO 425:utricle 312:pattern 38:Aliases 1935:  1900:  1892:  1863:  1834:  1805:  1784:  1755:  1747:  1718:  1689:  1668:  1646:  1625:  1590:  1569:  1562:395007 1559:  1526:  1489:  1443:  1378:  1370:  1360:  1296:  1126:enzyme 1124:is an 1080:search 1078:PubMed 951:O70362 932:P80108 828:Entrez 483:BioGPS 170:6p22.3 70:106604 62:602515 1968:is a 1898:S2CID 1753:S2CID 1376:S2CID 1179:APOA4 1173:with 1130:GPLD1 861:14756 821:Mouse 816:Human 787:Amigo 391:gonad 367:liver 335:Mouse 328:Human 275:Start 210:Mouse 174:Start 107:Human 86:GPLD1 45:GPLD1 22:GPLD1 1970:stub 1962:gene 1933:PMID 1890:PMID 1861:PMID 1832:PMID 1803:PMID 1782:PMID 1745:PMID 1716:PMID 1687:PMID 1666:PMID 1644:PMID 1623:PMID 1588:PMID 1567:PMID 1524:PMID 1487:PMID 1441:PMID 1368:PMID 1294:PMID 1282:1494 1177:and 1133:gene 842:2822 318:Bgee 266:Band 227:Chr. 165:Band 124:Chr. 78:1152 58:OMIM 1923:doi 1919:174 1882:doi 1878:371 1853:doi 1849:138 1824:doi 1774:doi 1770:325 1737:doi 1708:doi 1613:doi 1557:PMC 1549:doi 1516:doi 1504:252 1477:doi 1473:206 1431:doi 1358:PMC 1350:doi 1338:369 1286:doi 1047:n/a 288:End 187:End 90:OMA 66:MGI 2015:: 1931:. 1917:. 1913:. 1896:. 1888:. 1876:. 1859:. 1847:. 1830:. 1820:53 1818:. 1799:26 1797:. 1780:. 1768:. 1751:. 1743:. 1733:19 1731:. 1714:. 1704:80 1702:. 1683:53 1681:. 1662:53 1660:. 1640:24 1638:. 1621:. 1609:42 1607:. 1603:. 1584:45 1582:. 1565:. 1555:. 1545:13 1543:. 1539:. 1522:. 1514:. 1502:. 1485:. 1471:. 1467:. 1439:. 1427:42 1425:. 1421:. 1409:^ 1397:. 1374:. 1366:. 1356:. 1348:. 1336:. 1332:. 1306:^ 1292:. 1280:. 1261:. 1243:. 1214:^ 1193:^ 1181:. 1154:. 1135:. 789:/ 294:bp 281:bp 193:bp 180:bp 88:; 84:: 80:; 76:: 72:; 68:: 64:; 60:: 2001:e 1994:t 1987:v 1976:. 1939:. 1925:: 1904:. 1884:: 1867:. 1855:: 1838:. 1826:: 1809:. 1788:. 1776:: 1759:. 1739:: 1722:. 1710:: 1693:. 1672:. 1650:. 1629:. 1615:: 1594:. 1573:. 1551:: 1530:. 1518:: 1510:: 1493:. 1479:: 1447:. 1433:: 1403:. 1382:. 1352:: 1344:: 1317:. 1300:. 1288:: 1265:. 1247:. 212:) 109:) 92::

Index

Aliases
GPLD1
OMIM
602515
MGI
106604
HomoloGene
1152
GeneCards
GPLD1
OMA
GPLD1 - orthologs
Human
Chromosome 6 (human)
Chr.
Chromosome 6 (human)
Chromosome 6 (human)
Genomic location for GPLD1
Genomic location for GPLD1
Band
bp
bp
Mouse
Chromosome 13 (mouse)
Chr.
Chromosome 13 (mouse)
Genomic location for GPLD1
Genomic location for GPLD1
Band
bp

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