1316:) that specifically recognize adenosines within double-stranded regions of pre-mRNAs and deaminate them to inosine. Inosines are recognised as guanosine by the cells translational machinery. There are three members of the ADAR family ADARs 1-3, with ADAR1 and ADAR2 being the only enzymatically active members. ADAR3 is thought to have a regulatory role in the brain. ADAR1 and ADAR2 are widely expressed in tissues, whereas ADAR3 is restricted to the brain. The double-stranded regions of RNA are formed by base-pairing between residues in the close to region of the editing site, with residues usually in a neighboring intron, but can be an exonic sequence. The region that base-pairs with the editing region is known as an Editing Complementary Sequence (ECS). ADARs bind interact directly with the dsRNA substrate via their double-stranded RNA binding domains. If an editing site occurs within a coding sequence, the result could be a codon change. This can lead to translation of a protein isoform due to a change in its primary protein structure. Therefore, editing can also alter protein function. A to I editing occurs in a noncoding RNA sequences such as introns, untranslated regions (UTRs), LINEs, SINEs( especially Alu repeats). The function of A to I editing in these regions is thought to involve creation of splice sites and retention of RNAs in the nucleus, among others.
342:
319:
216:
241:
2533:
2593:
2563:
2548:
2578:
593:
600:
2608:
348:
247:
29:
1324:
The pre-mRNA of GluR-5 is edited at one position at the Q/R site located at membrane region 2 (M2). There is a codon change as a result of editing. The codon change is (CAG) Glutamine (Q) to (CGG) an
Arginine (R). Like GluR-6 the ECS is located about 2000 nucleotides downstream of the editing site.
55:
1275:. Two alternatively spliced transcript variants that encode different isoforms have been described. Exons of this gene are interspersed with exons from the C21orf41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein.
1498:
Hirbec, Hélène; Francis, Joanna C.; Lauri, Sari E.; Braithwaite, Steven P.; Coussen, Françoise; Mulle, Christophe; Dev, Kumlesh K.; Coutinho, Victoria; Meyer, Guido; Isaac, John T. R.; Collingridge, Graham L.; Henley, Jeremy M.; Couthino, Victoria (Feb 2003).
1354:
The editing site is found within the second intracellular domain. It is thought that editing affects the permeability of the receptor to CA2+. Editing of the Q/R site is thought to reduce the permeability of the channel to Ca2+
1333:
Editing of the Q/R site is development- and tissue-regulated. Editing in the spinal cord, corpus callosum, cerebellum is 50%, while editing in the
Thalamus, amygdala, hippocampus is about 70%.
2532:
2592:
2562:
2547:
1366:
For
Kainate receptors with only edited isoforms, these are strongly inhibited by these fatty acids. However, inclusion of just one nonedited subunit is enough to stop this inhibition(.
2577:
1896:
Korczak B, Nutt SL, Fletcher EJ, et al. (1996). "cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration".
2678:
1816:"The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis"
355:
254:
2776:
1559:
Seeburg PH, Single F, Kuner T, Higuchi M, Sprengel R (July 2001). "Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse".
1867:
Potier MC, Dutriaux A, Lambolez B, et al. (1993). "Assignment of the human glutamate receptor gene GLUR5 to 21q22 by screening a chromosome 21 YAC library".
1962:
Sander T, Hildmann T, Kretz R, et al. (1997). "Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism".
2241:
Ango F, Prézeau L, Muller T, et al. (2001). "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer".
2646:
2607:
888:
177:
869:
2286:
Shibata H, Joo A, Fujii Y, et al. (2002). "Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia".
3431:
2671:
3426:
2512:
1458:
2038:"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins"
1440:
1975:
341:
2092:
2664:
1991:
Clarke VR, Ballyk BA, Hoo KH, et al. (1997). "A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission".
1162:
1169:
318:
3087:
3075:
1917:
Brakeman PR, Lanahan AA, O'Brien R, et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors".
2161:
Barbon A, Barlati S (2000). "Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1".
3107:
2984:
1785:
Gregor P, O'Hara BF, Yang X, Uhl GR (1994). "Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6".
1479:
2079:
Montague AA, Greer CA (1999). "Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb".
1427:
1406:
3120:
240:
215:
1423:
2324:
52:
1609:
1248:
1402:
1268:
157:
2414:"Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP"
1501:"Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP"
2325:"The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs"
1284:
354:
253:
3142:
3099:
2116:
Bortolotto ZA, Clarke VR, Delany CM, et al. (1999). "Kainate receptors are involved in synaptic plasticity".
347:
246:
2942:
2505:
2656:
3156:
2695:
2637:
1252:
933:
165:
2457:"Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal"
1259:
subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by
914:
3343:
2541:: CRYSTAL STRUCTURE OF THE GLUR5 LIGAND BINDING CORE IN COMPLEX WITH GLUTAMATE AT 2.1 ANGSTROM RESOLUTION
2691:
229:
2601:: Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution
2498:
2250:
2211:
2125:
2000:
1926:
1827:
1617:
1363:
1264:
1605:"Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences"
144:
3356:
2571:: Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution
2556:: Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
1122:
1118:
1108:
1104:
1100:
1096:
1072:
1043:
1039:
1035:
1031:
1027:
1023:
1013:
1009:
1005:
2633:
3159:
2894:
2703:
2400:
2357:
2311:
2274:
2186:
2149:
2104:
2067:
2024:
1950:
1585:
1358:
RNA editing of the Q/R site can effect inhibition of the channel by membrane fatty acids such as
189:
1668:"Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids"
1126:
1092:
1068:
1064:
1001:
997:
677:
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
2371:"The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7"
2478:
2443:
2392:
2349:
2303:
2266:
2229:
2178:
2141:
2096:
2059:
2016:
1979:
1942:
1905:
1884:
1855:
1802:
1773:
1738:
1698:
1645:
1577:
1538:
1520:
592:
148:, EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5, glutamate ionotropic receptor kainate type subunit 1
137:
45:
2586:: Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution
3201:
2934:
2468:
2433:
2425:
2382:
2339:
2295:
2258:
2219:
2170:
2133:
2088:
2049:
2008:
1971:
1934:
1876:
1845:
1835:
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1730:
1688:
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1672:
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1528:
1512:
1375:
1359:
1272:
1256:
434:
365:
309:
264:
599:
185:
409:
1346:
Editing results in a change in amino acid in the second membrane domain of the receptor.
2254:
2215:
2129:
2004:
1930:
1831:
1621:
2768:
2720:
2438:
2413:
1693:
1667:
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28:
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641:
3420:
3246:
3176:
2760:
2712:
2650:
2299:
2153:
1850:
1815:
1798:
1734:
1640:
1604:
628:
2404:
2361:
2315:
2071:
1589:
3364:
2278:
2190:
2108:
2028:
1954:
1312:
A to I RNA editing is catalyzed by a family of adenosine deaminases acting on RNA (
427:
206:
169:
193:
2687:
1463:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1445:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1260:
510:
1561:
326:
223:
173:
1721:
Nutt SL, Kamboj RK (1995). "RNA editing of human kainate receptor subunits".
1524:
1976:
10.1002/(SICI)1096-8628(19970725)74:4<416::AID-AJMG13>3.0.CO;2-L
833:
570:
448:
393:
380:
292:
279:
181:
2482:
2473:
2456:
2447:
2396:
2353:
2344:
2307:
2270:
2233:
2182:
2145:
2100:
2093:
10.1002/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A
1880:
1702:
1630:
1581:
1542:
2063:
2020:
1983:
1946:
1909:
1888:
1859:
1840:
1806:
1777:
1742:
1684:
1649:
1209:
1204:
1193:
978:
959:
3291:
3286:
3035:
1229:
945:
900:
2174:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
3281:
3276:
3271:
3266:
3261:
3256:
3055:
3050:
3045:
3040:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2919:
2911:
2903:
2864:
2856:
2848:
2840:
2832:
2824:
2816:
2808:
2800:
2792:
2784:
2262:
2224:
2199:
1938:
1177:
855:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3324:
3316:
3251:
3226:
3221:
3216:
3211:
3195:
3190:
3185:
3180:
3065:
3060:
2966:
2958:
2950:
2887:
2882:
2877:
2872:
2748:
2743:
2738:
2733:
2728:
2616:: Structure and mechanism of kainate receptor modulation by anions
2137:
2012:
1296:
1292:
818:
814:
2974:
1752:"Transmembrane topology of the glutamate receptor subunit GluR6"
1313:
1288:
1236:
161:
2660:
2494:
608:
2490:
1480:"Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1"
1255:. The specific GluR subunit encoded by this gene is of the
2323:
Hirbec H, Perestenko O, Nishimune A, et al. (2002).
1814:
Eubanks JH, Puranam RS, Kleckner NW, et al. (1993).
1666:
Wilding TJ, Fulling E, Zhou Y, Huettner JE (July 2008).
1603:
Herb A, Higuchi M, Sprengel R, Seeburg PH (March 1996).
417:
1750:
Roche KW, Raymond LA, Blackstone C, Huganir RL (1994).
2198:
Hattori M, Fujiyama A, Taylor TD, et al. (2000).
582:
2412:
Hirbec H, Francis JC, Lauri SE, et al. (2003).
652:
extracellularly glutamate-gated ion channel activity
3355:
3342:
3302:
3237:
3167:
3155:
3133:
2983:
2933:
2759:
2711:
2702:
2455:Ren Z, Riley NJ, Needleman LA, et al. (2004).
1140:
1091:
1057:
996:
1419:
1417:
1415:
1398:
1396:
1394:
764:regulation of synaptic transmission, glutamatergic
364:
263:
2036:Xiao B, Tu JC, Petralia RS, et al. (1998).
784:ionotropic glutamate receptor signaling pathway
16:Protein-coding gene in the species Homo sapiens
1661:
1659:
1554:
1552:
1493:
1491:
1489:
1424:GRCm38: Ensembl release 89: ENSMUSG00000022935
2672:
2506:
804:regulation of postsynaptic membrane potential
647:kainate selective glutamate receptor activity
8:
799:modulation of chemical synaptic transmission
728:kainate selective glutamate receptor complex
1403:GRCh38: Ensembl release 89: ENSG00000171189
3352:
3164:
2708:
2679:
2665:
2657:
2647:United States National Library of Medicine
2513:
2499:
2491:
1088:
993:
829:
624:
405:
304:
201:
63:
2636:at the U.S. National Library of Medicine
2472:
2437:
2386:
2343:
2223:
2200:"The DNA sequence of human chromosome 21"
2053:
1849:
1839:
1767:
1692:
1639:
1629:
1532:
1222:Glutamate receptor, ionotropic, kainate 1
2645:This article incorporates text from the
1474:
1472:
2528:
1390:
657:ionotropic glutamate receptor activity
18:
713:integral component of plasma membrane
369:
330:
325:
268:
227:
222:
7:
794:synaptic transmission, glutamatergic
749:glutamate receptor signaling pathway
1251:(GluR) subunits that function as a
1247:This gene encodes one of the many
1137:
1054:
969:
950:
924:
905:
879:
860:
754:central nervous system development
587:
505:
443:
422:
14:
1232:that in humans is encoded by the
789:excitatory postsynaptic potential
662:ligand-gated ion channel activity
2606:
2591:
2576:
2561:
2546:
2531:
2300:10.1097/00041444-200109000-00005
1799:10.1097/00001756-199309150-00014
1735:10.1097/00001756-199412000-00055
598:
591:
353:
346:
340:
317:
252:
245:
239:
214:
27:
3432:Ionotropic glutamate receptors
779:chemical synaptic transmission
693:integral component of membrane
609:More reference expression data
571:More reference expression data
479:dorsolateral prefrontal cortex
1:
2430:10.1016/S0896-6273(02)01191-1
2388:10.1016/S0014-5793(02)02361-X
2055:10.1016/S0896-6273(00)80588-7
1769:10.1016/S0021-9258(17)32623-6
1610:Proc. Natl. Acad. Sci. U.S.A.
1574:10.1016/S0006-8993(01)02445-3
1517:10.1016/S0896-6273(02)01191-1
1249:ionotropic glutamate receptor
338:
237:
3427:Genes on human chromosome 21
1820:Proc. Natl. Acad. Sci. U.S.A
1511:(4). United States: 625–38.
1271:and are critical for normal
1269:excitatory neurotransmission
759:ion transmembrane transport
672:glutamate receptor activity
667:signaling receptor activity
487:paraflocculus of cerebellum
3448:
1267:. These receptors mediate
774:nervous system development
557:lateral geniculate nucleus
545:retinal pigment epithelium
3239:Voltage- and ligand-gated
2696:ligand-gated ion channels
2526:
1459:"Mouse PubMed Reference:"
1441:"Human PubMed Reference:"
1208:
1203:
1199:
1192:
1176:
1157:
1144:
1115:
1084:
1061:
1020:
989:
976:
972:
957:
953:
944:
931:
927:
912:
908:
899:
886:
882:
867:
863:
854:
839:
832:
828:
812:
627:
623:
606:
590:
581:
568:
533:medial geniculate nucleus
517:
508:
467:anterior cingulate cortex
455:
446:
416:
408:
404:
387:
374:
337:
316:
307:
303:
286:
273:
236:
213:
204:
200:
155:
152:
142:
135:
130:
71:
66:
49:
44:
39:
35:
26:
21:
2638:Medical Subject Headings
1283:GRIK1 has been shown to
1253:ligand-gated ion channel
1170:Chr 16: 87.69 – 88.09 Mb
1163:Chr 21: 29.54 – 29.94 Mb
549:anterior amygdaloid area
371:16 C3.3|16 50.23 cM
2985:Nicotinic acetylcholine
537:suprachiasmatic nucleus
2474:10.1074/jbc.M309585200
2345:10.1074/jbc.C200112200
1881:10.1006/geno.1993.1131
1631:10.1073/pnas.93.5.1875
525:neural layer of retina
521:lumbar spinal ganglion
2692:cell surface receptor
2163:Cytogenet. Cell Genet
1841:10.1073/pnas.90.1.178
1685:10.1085/jgp.200810009
708:postsynaptic membrane
332:Chromosome 16 (mouse)
230:Chromosome 21 (human)
3357:Purinergic receptors
2634:GRIK1+protein,+human
1364:docosahexaenoic acid
1265:alternative splicing
733:presynaptic membrane
642:ion channel activity
529:lateral hypothalamus
67:List of PDB id codes
40:Available structures
2255:2001Natur.411..962A
2216:2000Natur.405..311H
2130:1999Natur.402..297B
2005:1997Natur.389..599C
1931:1997Natur.386..284B
1832:1993PNAS...90..178E
1622:1996PNAS...93.1875H
3125:β1δε - Muscle type
2704:Cys-loop receptors
2649:, which is in the
934:ENSMUSG00000022935
742:Biological process
686:Cellular component
635:Molecular function
495:right frontal lobe
3414:
3413:
3410:
3409:
3338:
3337:
3169:Ligand-gated only
3151:
3150:
2624:
2623:
2175:10.1159/000015558
2124:(6759): 297–301.
1999:(6651): 599–603.
1964:Am. J. Med. Genet
1380:GRIK1 RNA editing
1273:synaptic function
1219:
1218:
1215:
1214:
1188:
1187:
1153:
1152:
1134:
1133:
1080:
1079:
1051:
1050:
985:
984:
966:
965:
940:
939:
921:
920:
895:
894:
876:
875:
824:
823:
619:
618:
615:
614:
577:
576:
564:
563:
502:
501:
475:prefrontal cortex
400:
399:
299:
298:
194:GRIK1 - orthologs
126:
125:
122:
121:
50:Ortholog search:
3439:
3353:
3165:
2709:
2681:
2674:
2667:
2658:
2610:
2595:
2580:
2565:
2550:
2535:
2515:
2508:
2501:
2492:
2486:
2476:
2451:
2441:
2408:
2390:
2365:
2347:
2329:
2319:
2288:Psychiatr. Genet
2282:
2263:10.1038/35082096
2237:
2227:
2225:10.1038/35012518
2194:
2157:
2112:
2075:
2057:
2032:
1987:
1958:
1939:10.1038/386284a0
1913:
1898:Recept. Channels
1892:
1863:
1853:
1843:
1810:
1781:
1771:
1762:(16): 11679–82.
1746:
1707:
1706:
1696:
1673:J. Gen. Physiol.
1663:
1654:
1653:
1643:
1633:
1600:
1594:
1593:
1556:
1547:
1546:
1536:
1495:
1484:
1483:
1476:
1467:
1466:
1455:
1449:
1448:
1437:
1431:
1421:
1410:
1400:
1376:Kainate receptor
1360:arachidonic acid
1257:kainate receptor
1224:, also known as
1201:
1200:
1172:
1165:
1148:
1138:
1129:
1089:
1085:RefSeq (protein)
1075:
1055:
1046:
994:
970:
951:
925:
906:
880:
861:
830:
625:
611:
602:
595:
588:
573:
513:
511:Top expressed in
506:
451:
449:Top expressed in
444:
423:
406:
396:
383:
372:
357:
350:
344:
333:
321:
305:
295:
282:
271:
256:
249:
243:
232:
218:
202:
196:
147:
140:
117:
64:
58:
37:
36:
31:
19:
3447:
3446:
3442:
3441:
3440:
3438:
3437:
3436:
3417:
3416:
3415:
3406:
3334:
3328:
3320:
3298:
3233:
3147:
3129:
3124:
3116:- Ganglion type
3115:
3111:
3103:
3095:
3091:
3083:
3079:
2979:
2970:
2962:
2954:
2946:
2929:
2923:
2915:
2907:
2898:
2868:
2860:
2852:
2844:
2836:
2828:
2820:
2812:
2804:
2796:
2788:
2780:
2772:
2755:
2724:
2698:
2685:
2630:
2625:
2620:
2617:
2611:
2602:
2596:
2587:
2581:
2572:
2566:
2557:
2551:
2542:
2536:
2522:
2519:
2489:
2467:(52): 52700–9.
2454:
2411:
2368:
2338:(18): 15221–4.
2327:
2322:
2285:
2249:(6840): 962–5.
2240:
2210:(6784): 311–9.
2197:
2160:
2115:
2081:J. Comp. Neurol
2078:
2035:
1990:
1961:
1925:(6622): 284–8.
1916:
1895:
1866:
1813:
1784:
1749:
1720:
1716:
1714:Further reading
1711:
1710:
1665:
1664:
1657:
1602:
1601:
1597:
1568:(1–2): 233–43.
1558:
1557:
1550:
1497:
1496:
1487:
1478:
1477:
1470:
1457:
1456:
1452:
1439:
1438:
1434:
1422:
1413:
1401:
1392:
1387:
1372:
1352:
1344:
1339:
1331:
1322:
1310:
1305:
1281:
1245:
1210:View/Edit Mouse
1205:View/Edit Human
1168:
1161:
1158:Location (UCSC)
1146:
1125:
1121:
1117:
1111:
1107:
1103:
1099:
1095:
1071:
1067:
1063:
1042:
1038:
1034:
1030:
1026:
1022:
1016:
1012:
1008:
1004:
1000:
915:ENSG00000171189
808:
737:
703:plasma membrane
681:
607:
597:
596:
569:
560:
555:
551:
547:
543:
539:
535:
531:
527:
523:
509:
498:
493:
489:
485:
481:
477:
473:
469:
465:
463:cingulate gyrus
461:
447:
391:
378:
370:
360:
359:
358:
351:
331:
308:Gene location (
290:
277:
269:
259:
258:
257:
250:
228:
205:Gene location (
156:
143:
136:
73:
51:
17:
12:
11:
5:
3445:
3443:
3435:
3434:
3429:
3419:
3418:
3412:
3411:
3408:
3407:
3405:
3404:
3403:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3361:
3359:
3350:
3348:gated channels
3340:
3339:
3336:
3335:
3333:
3332:
3331:
3330:
3326:
3322:
3318:
3308:
3306:
3300:
3299:
3297:
3296:
3295:
3294:
3289:
3284:
3279:
3274:
3269:
3264:
3259:
3254:
3243:
3241:
3235:
3234:
3232:
3231:
3230:
3229:
3224:
3219:
3214:
3209:
3199:
3193:
3188:
3183:
3173:
3171:
3162:
3153:
3152:
3149:
3148:
3146:
3145:
3143:Zinc-activated
3139:
3137:
3131:
3130:
3128:
3127:
3122:
3118:
3113:
3109:
3105:
3101:
3097:
3093:
3089:
3085:
3081:
3077:
3069:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2989:
2987:
2981:
2980:
2978:
2977:
2972:
2968:
2964:
2960:
2956:
2952:
2948:
2944:
2939:
2937:
2931:
2930:
2928:
2927:
2926:
2925:
2921:
2917:
2913:
2909:
2905:
2896:
2892:
2891:
2890:
2885:
2880:
2875:
2870:
2866:
2862:
2858:
2854:
2850:
2846:
2842:
2838:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2786:
2782:
2778:
2770:
2765:
2763:
2757:
2756:
2754:
2753:
2752:
2751:
2746:
2741:
2736:
2731:
2722:
2717:
2715:
2713:5-HT/serotonin
2706:
2700:
2699:
2686:
2684:
2683:
2676:
2669:
2661:
2642:
2641:
2629:
2628:External links
2626:
2622:
2621:
2619:
2618:
2612:
2605:
2603:
2597:
2590:
2588:
2582:
2575:
2573:
2567:
2560:
2558:
2552:
2545:
2543:
2537:
2530:
2527:
2524:
2523:
2520:
2518:
2517:
2510:
2503:
2495:
2488:
2487:
2452:
2409:
2381:(2–3): 184–8.
2369:Enz R (2002).
2366:
2320:
2283:
2238:
2195:
2169:(3–4): 236–9.
2158:
2113:
2076:
2033:
1988:
1959:
1914:
1893:
1864:
1811:
1793:(12): 1343–6.
1782:
1747:
1729:(18): 2625–9.
1717:
1715:
1712:
1709:
1708:
1655:
1616:(5): 1875–80.
1595:
1548:
1485:
1468:
1450:
1432:
1411:
1389:
1388:
1386:
1383:
1382:
1381:
1378:
1371:
1368:
1351:
1348:
1343:
1340:
1338:
1335:
1330:
1327:
1321:
1318:
1309:
1306:
1304:
1301:
1280:
1277:
1244:
1241:
1217:
1216:
1213:
1212:
1207:
1197:
1196:
1190:
1189:
1186:
1185:
1183:
1181:
1174:
1173:
1166:
1159:
1155:
1154:
1151:
1150:
1142:
1141:
1135:
1132:
1131:
1113:
1112:
1086:
1082:
1081:
1078:
1077:
1059:
1058:
1052:
1049:
1048:
1018:
1017:
991:
987:
986:
983:
982:
974:
973:
967:
964:
963:
955:
954:
948:
942:
941:
938:
937:
929:
928:
922:
919:
918:
910:
909:
903:
897:
896:
893:
892:
884:
883:
877:
874:
873:
865:
864:
858:
852:
851:
846:
841:
837:
836:
826:
825:
822:
821:
810:
809:
807:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
745:
743:
739:
738:
736:
735:
730:
725:
720:
715:
710:
705:
700:
695:
689:
687:
683:
682:
680:
679:
674:
669:
664:
659:
654:
649:
644:
638:
636:
632:
631:
621:
620:
617:
616:
613:
612:
604:
603:
585:
579:
578:
575:
574:
566:
565:
562:
561:
559:
558:
554:
550:
546:
542:
541:pontine nuclei
538:
534:
530:
526:
522:
518:
515:
514:
503:
500:
499:
497:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
453:
452:
440:
439:
431:
420:
414:
413:
410:RNA expression
402:
401:
398:
397:
389:
385:
384:
376:
373:
368:
362:
361:
352:
345:
339:
335:
334:
329:
323:
322:
314:
313:
301:
300:
297:
296:
288:
284:
283:
275:
272:
267:
261:
260:
251:
244:
238:
234:
233:
226:
220:
219:
211:
210:
198:
197:
154:
150:
149:
141:
133:
132:
128:
127:
124:
123:
120:
119:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3444:
3433:
3430:
3428:
3425:
3424:
3422:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3367:
3366:
3363:
3362:
3360:
3358:
3354:
3351:
3349:
3345:
3341:
3329:
3323:
3321:
3315:
3314:
3313:
3310:
3309:
3307:
3305:
3301:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3249:
3248:
3245:
3244:
3242:
3240:
3236:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3204:
3203:
3200:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3178:
3175:
3174:
3172:
3170:
3166:
3163:
3161:
3158:
3154:
3144:
3141:
3140:
3138:
3136:
3132:
3126:
3119:
3117:
3106:
3104:
3098:
3096:
3086:
3084:
3074:
3071:
3070:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2991:
2990:
2988:
2986:
2982:
2976:
2973:
2971:
2965:
2963:
2957:
2955:
2949:
2947:
2941:
2940:
2938:
2936:
2932:
2924:
2918:
2916:
2910:
2908:
2902:
2901:
2900:
2893:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2863:
2861:
2855:
2853:
2847:
2845:
2839:
2837:
2831:
2829:
2823:
2821:
2815:
2813:
2807:
2805:
2799:
2797:
2791:
2789:
2783:
2781:
2775:
2774:
2773:
2767:
2766:
2764:
2762:
2758:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2726:
2725:
2719:
2718:
2716:
2714:
2710:
2707:
2705:
2701:
2697:
2693:
2689:
2682:
2677:
2675:
2670:
2668:
2663:
2662:
2659:
2655:
2654:
2652:
2651:public domain
2648:
2639:
2635:
2632:
2631:
2627:
2615:
2609:
2604:
2600:
2594:
2589:
2585:
2579:
2574:
2570:
2564:
2559:
2555:
2549:
2544:
2540:
2534:
2529:
2525:
2516:
2511:
2509:
2504:
2502:
2497:
2496:
2493:
2484:
2480:
2475:
2470:
2466:
2462:
2461:J. Biol. Chem
2458:
2453:
2449:
2445:
2440:
2435:
2431:
2427:
2424:(4): 625–38.
2423:
2419:
2415:
2410:
2406:
2402:
2398:
2394:
2389:
2384:
2380:
2376:
2372:
2367:
2363:
2359:
2355:
2351:
2346:
2341:
2337:
2333:
2332:J. Biol. Chem
2326:
2321:
2317:
2313:
2309:
2305:
2301:
2297:
2294:(3): 139–44.
2293:
2289:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2248:
2244:
2239:
2235:
2231:
2226:
2221:
2217:
2213:
2209:
2205:
2201:
2196:
2192:
2188:
2184:
2180:
2176:
2172:
2168:
2164:
2159:
2155:
2151:
2147:
2143:
2139:
2138:10.1038/46290
2135:
2131:
2127:
2123:
2119:
2114:
2110:
2106:
2102:
2098:
2094:
2090:
2087:(2): 233–46.
2086:
2082:
2077:
2073:
2069:
2065:
2061:
2056:
2051:
2048:(4): 707–16.
2047:
2043:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2013:10.1038/39315
2010:
2006:
2002:
1998:
1994:
1989:
1985:
1981:
1977:
1973:
1970:(4): 416–21.
1969:
1965:
1960:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1915:
1911:
1907:
1903:
1899:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1865:
1861:
1857:
1852:
1847:
1842:
1837:
1833:
1829:
1826:(1): 178–82.
1825:
1821:
1817:
1812:
1808:
1804:
1800:
1796:
1792:
1788:
1783:
1779:
1775:
1770:
1765:
1761:
1757:
1756:J. Biol. Chem
1753:
1748:
1744:
1740:
1736:
1732:
1728:
1724:
1719:
1718:
1713:
1704:
1700:
1695:
1690:
1686:
1682:
1678:
1675:
1674:
1669:
1662:
1660:
1656:
1651:
1647:
1642:
1637:
1632:
1627:
1623:
1619:
1615:
1612:
1611:
1606:
1599:
1596:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1564:
1563:
1555:
1553:
1549:
1544:
1540:
1535:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1502:
1494:
1492:
1490:
1486:
1481:
1475:
1473:
1469:
1464:
1460:
1454:
1451:
1446:
1442:
1436:
1433:
1429:
1425:
1420:
1418:
1416:
1412:
1408:
1404:
1399:
1397:
1395:
1391:
1384:
1379:
1377:
1374:
1373:
1369:
1367:
1365:
1361:
1356:
1349:
1347:
1341:
1336:
1334:
1328:
1326:
1319:
1317:
1315:
1307:
1302:
1300:
1298:
1294:
1290:
1286:
1278:
1276:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1242:
1240:
1238:
1235:
1231:
1227:
1223:
1211:
1206:
1202:
1198:
1195:
1191:
1184:
1182:
1179:
1175:
1171:
1167:
1164:
1160:
1156:
1149:
1143:
1139:
1136:
1130:
1128:
1124:
1120:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1087:
1083:
1076:
1074:
1070:
1066:
1060:
1056:
1053:
1047:
1045:
1041:
1037:
1033:
1029:
1025:
1019:
1015:
1011:
1007:
1003:
999:
995:
992:
990:RefSeq (mRNA)
988:
981:
980:
975:
971:
968:
962:
961:
956:
952:
949:
947:
943:
936:
935:
930:
926:
923:
917:
916:
911:
907:
904:
902:
898:
891:
890:
885:
881:
878:
872:
871:
866:
862:
859:
857:
853:
850:
847:
845:
842:
838:
835:
831:
827:
820:
816:
811:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
769:ion transport
767:
765:
762:
760:
757:
755:
752:
750:
747:
746:
744:
741:
740:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
698:cell junction
696:
694:
691:
690:
688:
685:
684:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
630:
629:Gene ontology
626:
622:
610:
605:
601:
594:
589:
586:
584:
580:
572:
567:
556:
553:barrel cortex
552:
548:
544:
540:
536:
532:
528:
524:
520:
519:
516:
512:
507:
504:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
457:
454:
450:
445:
442:
441:
438:
436:
432:
430:
429:
425:
424:
421:
419:
415:
411:
407:
403:
395:
390:
386:
382:
377:
367:
363:
356:
349:
343:
336:
328:
324:
320:
315:
311:
306:
302:
294:
289:
285:
281:
276:
266:
262:
255:
248:
242:
235:
231:
225:
221:
217:
212:
208:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
151:
146:
139:
134:
129:
118:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3347:
3311:
3303:
3238:
3206:
3168:
3134:
3072:
2992:
2644:
2643:
2613:
2598:
2583:
2568:
2553:
2538:
2464:
2460:
2421:
2417:
2378:
2374:
2335:
2331:
2291:
2287:
2246:
2242:
2207:
2203:
2166:
2162:
2121:
2117:
2084:
2080:
2045:
2041:
1996:
1992:
1967:
1963:
1922:
1918:
1901:
1897:
1875:(3): 696–7.
1872:
1868:
1823:
1819:
1790:
1786:
1759:
1755:
1726:
1722:
1679:(1): 85–99.
1676:
1671:
1613:
1608:
1598:
1565:
1560:
1508:
1504:
1462:
1453:
1444:
1435:
1357:
1353:
1345:
1337:Consequences
1332:
1323:
1311:
1282:
1279:Interactions
1246:
1233:
1225:
1221:
1220:
1145:
1123:NP_001317923
1119:NP_001317922
1116:
1109:NP_001307559
1105:NP_001307550
1101:NP_001307547
1097:NP_001307545
1073:NM_001346964
1062:
1044:NM_001393426
1040:NM_001393425
1036:NM_001393424
1032:NM_001330994
1028:NM_001330993
1024:NM_001320630
1021:
1014:NM_001320621
1010:NM_001320618
1006:NM_001320616
977:
958:
932:
913:
887:
868:
848:
843:
491:hypothalamus
483:frontal pole
433:
426:
153:External IDs
72:
2688:Ion channel
2521:PDB gallery
1904:(1): 41–9.
1787:NeuroReport
1723:NeuroReport
1303:RNA editing
1261:RNA editing
392:88,087,153
379:87,692,788
291:29,940,033
278:29,536,933
131:Identifiers
3421:Categories
3160:glutamates
3157:Ionotropic
3073:pentamers:
1562:Brain Res.
1430:, May 2017
1409:, May 2017
1385:References
1329:Regulation
437:(ortholog)
174:HomoloGene
2993:monomers:
2375:FEBS Lett
2154:205051834
1525:0896-6273
1342:Structure
1127:NP_783300
1093:NP_000821
1069:NM_146072
1065:NM_010348
1002:NM_175611
998:NM_000830
834:Orthologs
182:GeneCards
3304:‘Orphan’
2483:14527949
2448:12597860
2405:44474808
2397:11943148
2362:13732968
2354:11891216
2316:38356907
2308:11702055
2271:11418862
2234:10830953
2183:10828597
2146:10580501
2101:10023812
2072:16431031
1869:Genomics
1703:18562501
1590:11969068
1582:11430906
1543:12597860
1426:–
1405:–
1370:See also
1350:Function
1320:Location
1285:interact
1243:Function
1194:Wikidata
813:Sources:
723:membrane
471:amygdala
459:testicle
3202:Kainate
2935:Glycine
2439:3314502
2279:4417727
2251:Bibcode
2212:Bibcode
2191:5850944
2126:Bibcode
2109:1317987
2064:9808458
2029:4426839
2021:9335499
2001:Bibcode
1984:9259378
1955:4346579
1947:9069287
1927:Bibcode
1910:8589992
1889:8468067
1860:8419920
1828:Bibcode
1807:8260617
1778:8163463
1743:7696618
1694:2442176
1650:8700852
1618:Bibcode
1534:3314502
1428:Ensembl
1407:Ensembl
1230:protein
1228:, is a
946:UniProt
901:Ensembl
840:Species
819:QuickGO
718:synapse
412:pattern
270:21q21.3
138:Aliases
2640:(MeSH)
2481:
2446:
2436:
2418:Neuron
2403:
2395:
2360:
2352:
2314:
2306:
2277:
2269:
2243:Nature
2232:
2204:Nature
2189:
2181:
2152:
2144:
2118:Nature
2107:
2099:
2070:
2062:
2042:Neuron
2027:
2019:
1993:Nature
1982:
1953:
1945:
1919:Nature
1908:
1887:
1858:
1848:
1805:
1776:
1741:
1701:
1691:
1648:
1638:
1588:
1580:
1541:
1531:
1523:
1505:Neuron
1180:search
1178:PubMed
979:Q60934
960:P39086
856:Entrez
583:BioGPS
162:138245
2401:S2CID
2358:S2CID
2328:(PDF)
2312:S2CID
2275:S2CID
2187:S2CID
2150:S2CID
2105:S2CID
2068:S2CID
2025:S2CID
1951:S2CID
1851:45623
1641:39875
1586:S2CID
1314:ADARs
1297:SDCBP
1293:PICK1
1287:with
1234:GRIK1
1226:GRIK1
889:14805
849:Mouse
844:Human
815:Amigo
435:Mouse
428:Human
375:Start
310:Mouse
274:Start
207:Human
186:GRIK1
178:68992
170:95814
145:GRIK1
22:GRIK1
3312:GluD
3247:NMDA
3177:AMPA
3135:Zinc
3121:(α1)
3112:(β4)
3108:(α1)
3100:(α7)
3092:(β2)
3088:(α4)
3080:(β4)
3076:(α3)
2895:GABA
2769:GABA
2761:GABA
2721:5-HT
2614:2ojt
2599:2f36
2584:2f35
2569:2f34
2554:1ycj
2539:1txf
2479:PMID
2444:PMID
2393:PMID
2350:PMID
2304:PMID
2267:PMID
2230:PMID
2179:PMID
2142:PMID
2097:PMID
2060:PMID
2017:PMID
1980:PMID
1943:PMID
1906:PMID
1885:PMID
1856:PMID
1803:PMID
1774:PMID
1739:PMID
1699:PMID
1646:PMID
1578:PMID
1539:PMID
1521:ISSN
1362:and
1308:Type
1295:and
1289:DLG4
1263:and
1237:gene
870:2897
418:Bgee
366:Band
327:Chr.
265:Band
224:Chr.
158:OMIM
115:4MF3
111:3FVO
107:3FVN
103:3FVK
99:3FVG
95:3FV2
91:3FV1
87:3FUZ
83:2ZNU
79:2ZNT
75:2ZNS
56:RCSB
53:PDBe
3365:P2X
3344:ATP
3292:L1B
3287:L1A
3036:α10
2469:doi
2465:278
2434:PMC
2426:doi
2383:doi
2379:514
2340:doi
2336:277
2296:doi
2259:doi
2247:411
2220:doi
2208:405
2171:doi
2134:doi
2122:402
2089:doi
2085:405
2050:doi
2009:doi
1997:389
1972:doi
1935:doi
1923:386
1877:doi
1846:PMC
1836:doi
1795:doi
1764:doi
1760:269
1731:doi
1689:PMC
1681:doi
1677:132
1636:PMC
1626:doi
1570:doi
1566:907
1529:PMC
1513:doi
1147:n/a
388:End
287:End
190:OMA
166:MGI
46:PDB
3423::
3282:3B
3277:3A
3272:2D
3267:2C
3262:2B
3257:2A
3056:β4
3051:β3
3046:β2
3041:β1
3031:α9
3026:α7
3021:α6
3016:α5
3011:α4
3006:α3
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2996:α1
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