301:
278:
175:
200:
559:
552:
307:
206:
4990:
5010:
1181:, removing the receptors from the cell surface and also preventing additional activation. Arrestin binding to phosphorylated, active receptor also enables receptor signaling through arrestin partner proteins. Thus the GRK/arrestin system serves as a complex signaling switch for G protein-coupled receptors.
1204:
GRK5 is widely expressed throughout the body, but with notably high expression in the lung, heart and placenta, with widespread expression at lower levels. In humans, a GRK5 sequence polymorphism at residue 41 (leucine rather than glutamine) that is most common in individuals with
African ancestry
50:
2194:
Bullrich F, Druck T, Kunapuli P, Gomez J, Gripp KW, Schlegelberger B, Lasota J, Aronson M, Cannizzaro LA, Huebner K (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6".
1184:
GRK5 and the closely related GRK6 phosphorylate receptors at sites that encourage arrestin-mediated signaling rather than arrestin-mediated receptor desensitization, internalization and trafficking (in contrast to
1876:
Walker JK, Gainetdinov RR, Feldman DS, McFawn PK, Caron MG, Lefkowitz RJ, Premont RT, Fisher JT (2004). "G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation".
2853:
3138:
2846:
1229:. Overexpression of GRK5 in the heart of mice has shown that GRK5 regulates beta2-adrenergic receptors, but GRK5 overexpression or deletion does not affect signaling by the
2839:
3046:
314:
213:
1969:
Lessel D, Muhammad T, Casar Tena T, Moepps B, Burkhalter MD, Hitz MP, Toka O, Rentzsch A, Schubert S, Schalinski A, Bauer UM, Kubisch C, Ware SM, Philipp M (2016).
3594:
4433:
2897:
2664:"Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation"
4542:
3280:
3167:
867:
3555:
2697:
Zhou H, Yan F, Tai HH (Sep 2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases".
848:
136:
4528:
3993:
2884:
2866:
5084:
4630:
4511:
2471:"beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein"
1201:), where a drug binding to a receptor may bias that receptor's signaling toward a particular subset of the actions stimulated by that receptor.
5055:
4217:
3086:
5074:
4281:
3256:
1310:
1292:
4537:
300:
3071:
1067:
4594:
4269:
1074:
277:
4709:
3526:
3516:
3201:
1503:"Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling"
1214:
1130:
4208:
1436:
4477:
4149:
3511:
3502:
1562:"Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor"
1279:
1258:
199:
174:
4865:
1780:"A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors"
1275:
47:
3892:
3389:
3380:
3037:
2983:
1912:
He M, Singh P, Cheng S, Zhang Q, Peng W, Ding X, Li L, Liu J, Premont RT, Morgan D, Burns JM, Swerdlow RH, Suo WZ (2016).
4980:
1829:"Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice"
1254:
1165:
G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an
3080:
2790:"Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro"
2436:"Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation"
116:
2366:"Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor"
1150:
2085:
Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ (2006).
2831:
313:
212:
5048:
4104:
3922:
3418:
2331:"Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C"
1174:
4850:
4966:
4953:
4940:
4927:
4914:
4901:
4888:
4094:
4089:
4084:
4074:
4069:
4064:
4054:
3849:
3624:
3220:
306:
205:
4860:
1621:"Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands"
4814:
4757:
4317:
4308:
4259:
3025:
2870:
2469:
Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (Nov 1998).
2087:"Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes"
1170:
912:
124:
2296:"Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor"
1169:
protein to the receptor. Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of
4762:
4617:
4040:
2151:"Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases"
1230:
893:
2720:"Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function"
1218:
1198:
2028:"Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice"
5041:
4783:
4702:
3316:
188:
4855:
1827:
Gainetdinov RR, Bohn LM, Walker JK, Laporte SA, Macrae AD, Caron MG, Lefkowitz RJ, Premont RT (1999).
3883:
2559:"Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium"
2482:
2098:
2039:
1982:
1925:
1732:
1632:
1573:
1514:
1341:
2592:
Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (Jan 2000).
1680:"G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor"
103:
4819:
1206:
1154:
4391:
2755:"G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95"
2226:"Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5"
1221:. In zebrafish and in humans, loss of GRK5 function has been associated with heart defects due to
5079:
4752:
4494:
4448:
2819:
1858:
1418:
148:
2718:
Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I (Nov 2001).
1050:
1029:
1003:
982:
3754:
3463:
2811:
2776:
2741:
2706:
2685:
2650:
2615:
2580:
2545:
2510:
2457:
2422:
2387:
2352:
2317:
2282:
2261:"Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5"
2247:
2212:
2182:
2126:
2067:
2008:
1951:
1894:
1850:
1809:
1760:
1701:
1660:
1601:
1542:
1483:
1410:
1369:
96:
40:
5025:
2788:
Warabi K, Richardson MD, Barry WT, Yamaguchi K, Roush ED, Nishimura K, Kwatra MM (Jun 2002).
4798:
4793:
4767:
4695:
4347:
3589:
3579:
3574:
3492:
3483:
3413:
3404:
3350:
3341:
2998:
2801:
2766:
2731:
2675:
2640:
2605:
2570:
2535:
2500:
2490:
2447:
2412:
2377:
2342:
2307:
2272:
2237:
2204:
2172:
2162:
2116:
2106:
2057:
2047:
1998:
1990:
1941:
1933:
1886:
1840:
1799:
1791:
1750:
1740:
1691:
1650:
1640:
1591:
1581:
1532:
1522:
1473:
1463:
1400:
1359:
1349:
558:
551:
393:
324:
268:
223:
4845:
4829:
4742:
4173:
3244:
3239:
3234:
1721:"Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family"
1330:"Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family"
1146:
368:
144:
2486:
2102:
2043:
1986:
1929:
1736:
1636:
1577:
1518:
1345:
4994:
4883:
4824:
2177:
2150:
2121:
2086:
2003:
1970:
1946:
1914:"GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability"
1913:
1804:
1779:
1655:
1620:
1478:
1451:
1225:, a series of developmental defects arising from improper left-right laterality during
1194:
1134:
2806:
2789:
2277:
2260:
2242:
2225:
1845:
1828:
1596:
1561:
1537:
1502:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
701:
696:
691:
686:
681:
676:
671:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
5068:
5021:
4788:
4747:
3297:
3229:
2505:
2470:
2062:
2027:
1755:
1720:
1364:
1329:
1226:
587:
2823:
2594:"Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein"
1422:
1193:, which have the opposite effect). This difference is one basis for pharmacological
4737:
4168:
2993:
2629:"Synucleins are a novel class of substrates for G protein-coupled receptor kinases"
2294:
Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M (Apr 1996).
1971:"The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5"
1862:
386:
165:
128:
1795:
1173:
transducer proteins, blocking their cellular signaling and resulting in receptor
152:
4961:
4896:
4732:
4374:
4006:
3946:
3829:
3749:
3473:
1315:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1297:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1217:
in airways and neurons, and mice lacking GRK5 have been proposed as a model for
1178:
4989:
1890:
1405:
1388:
469:
4462:
2936:
1696:
1679:
1222:
285:
182:
132:
2495:
2452:
2435:
2382:
2365:
2347:
2330:
2312:
2295:
1468:
4935:
4909:
3423:
2540:
2523:
2401:"Normalization and subtraction: two approaches to facilitate gene discovery"
2167:
2111:
2052:
1745:
1678:
Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ (2018).
1645:
1586:
1527:
1354:
812:
529:
407:
352:
339:
251:
238:
140:
2815:
2780:
2771:
2754:
2745:
2736:
2719:
2710:
2689:
2680:
2663:
2654:
2645:
2628:
2619:
2584:
2549:
2186:
2130:
2012:
1955:
1898:
1854:
1813:
1705:
1664:
1605:
1546:
1487:
2610:
2593:
2575:
2558:
2514:
2461:
2426:
2391:
2356:
2321:
2286:
2251:
2216:
2071:
1764:
1414:
1389:"Protein kinases that phosphorylate activated G protein-coupled receptors"
1373:
1114:
1109:
3779:
3674:
3669:
3664:
2026:
Rockman HA, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, Koch WJ (1996).
1166:
1098:
957:
938:
723:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
4438:
4416:
4411:
4401:
4396:
4198:
4193:
4188:
4183:
4178:
4163:
4158:
3809:
3774:
3013:
3008:
3003:
2417:
2400:
1501:
Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ (2005).
924:
879:
2208:
1994:
1937:
1879:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
73:
69:
4948:
4718:
4668:
4663:
4658:
4653:
4648:
4643:
4638:
4589:
4584:
4579:
4574:
4569:
4552:
4547:
4421:
4406:
4357:
4352:
4337:
4332:
4327:
4322:
4296:
4291:
4286:
4274:
4252:
4247:
4139:
4114:
3789:
3614:
3609:
3604:
3599:
3584:
3428:
3365:
3360:
3355:
3331:
3157:
3152:
3126:
3121:
3116:
3106:
3101:
3091:
2931:
2862:
1210:
1082:
834:
5009:
2557:
Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (Sep 1999).
1778:
Wang WC, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB (2008).
4922:
4564:
4557:
4467:
4364:
4264:
4242:
4237:
4232:
4227:
4222:
4134:
4129:
4124:
4119:
4109:
4079:
4059:
3936:
3931:
3912:
3907:
3897:
3873:
3868:
3863:
3839:
3834:
3824:
3819:
3814:
3804:
3784:
3769:
3764:
3759:
3739:
3734:
3724:
3719:
3714:
3709:
3704:
3694:
3689:
3684:
3679:
3659:
3654:
3649:
3644:
3639:
3634:
3619:
3569:
3564:
3458:
3453:
3448:
3443:
3438:
3433:
3394:
3326:
3321:
3270:
3265:
3191:
3186:
3181:
3147:
3139:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2941:
2926:
2921:
2916:
2911:
2906:
2329:
Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (May 1996).
797:
793:
5017:
4457:
4384:
4379:
4369:
4342:
4099:
4049:
4030:
4025:
4020:
4015:
3970:
3965:
3960:
3955:
3902:
3858:
3799:
3794:
3744:
3729:
3699:
3629:
3545:
3535:
3468:
3370:
3311:
3306:
3210:
3176:
3061:
3056:
3051:
3020:
2988:
2976:
2971:
2966:
2956:
2951:
1190:
1186:
1142:
1138:
120:
4691:
4615:
3991:
2882:
2835:
1177:. Arrestin binding also directs receptors to specific cellular
567:
4426:
2961:
2946:
2524:"Regulation of G protein-coupled receptor kinases by caveolin"
1560:
Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ (2005).
2753:
Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002).
1452:"GPCR Signaling Regulation: The Role of GRKs and Arrestins"
4687:
2662:
Berrada K, Plesnicher CL, Luo X, Thibonnier M (Sep 2000).
2627:
Pronin AN, Morris AJ, Surguchov A, Benovic JL (Aug 2000).
1205:
leads to elevated GRK5-mediated desensitization of airway
778:
regulation of G protein-coupled receptor signaling pathway
2699:
The
Journal of Pharmacology and Experimental Therapeutics
2259:
Kunapuli P, Onorato JJ, Hosey MM, Benovic JL (Jan 1994).
376:
5029:
1437:"Entrez Gene: GRK5 G protein-coupled receptor kinase 5"
4978:
1619:
Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ (2009).
541:
2364:
Fredericks ZL, Pitcher JA, Lefkowitz RJ (Jun 1996).
753:
positive regulation of cell population proliferation
107:, GPRK5, G protein-coupled receptor kinase 5, FP2025
4874:
4838:
4807:
4776:
4725:
4629:
4527:
4510:
4493:
4476:
4447:
4307:
4207:
4148:
4039:
4005:
3945:
3921:
3882:
3848:
3554:
3525:
3501:
3482:
3403:
3379:
3340:
3296:
3279:
3255:
3219:
3200:
3166:
3137:
3070:
3036:
2896:
1043:
1022:
996:
975:
1271:
1269:
1267:
1250:
1248:
1246:
1213:. In the mouse, GRK5 regulates the M2 subtype of
323:
222:
2224:Kunapuli P, Gurevich VV, Benovic JL (Apr 1994).
2475:Proceedings of the National Academy of Sciences
2149:Komolov KE, Bhardwaj A, Benovic JL (Aug 2015).
2091:Proceedings of the National Academy of Sciences
2032:Proceedings of the National Academy of Sciences
1725:Proceedings of the National Academy of Sciences
1625:Proceedings of the National Academy of Sciences
1566:Proceedings of the National Academy of Sciences
1507:Proceedings of the National Academy of Sciences
1334:Proceedings of the National Academy of Sciences
16:Protein-coding gene in the species Homo sapiens
2522:Carman CV, Lisanti MP, Benovic JL (Mar 1999).
1276:GRCm38: Ensembl release 89: ENSMUSG00000003228
5049:
4703:
2898:Non-specific serine/threonine protein kinases
2847:
2434:Pronin AN, Carman CV, Benovic JL (Nov 1998).
8:
2399:Bonaldo MF, Lennon G, Soares MB (Sep 1996).
1387:Premont RT, Inglese J, Lefkowitz RJ (1995).
783:G protein-coupled receptor signaling pathway
1255:GRCh38: Ensembl release 89: ENSG00000198873
5056:
5042:
4710:
4696:
4688:
4626:
4612:
4002:
3988:
3281:Goodpasture-antigen-binding protein kinase
2893:
2879:
2854:
2840:
2832:
808:
616:G protein-coupled receptor kinase activity
583:
364:
263:
160:
58:
3994:Serine/threonine-specific protein kinases
3168:(isocitrate dehydrogenase (NADP+)) kinase
2885:Serine/threonine-specific protein kinases
2867:Serine/threonine-specific protein kinases
2805:
2770:
2735:
2679:
2644:
2609:
2574:
2539:
2504:
2494:
2451:
2416:
2381:
2346:
2311:
2276:
2241:
2176:
2166:
2120:
2110:
2061:
2051:
2002:
1945:
1844:
1803:
1754:
1744:
1695:
1654:
1644:
1595:
1585:
1536:
1526:
1477:
1467:
1404:
1363:
1353:
4529:Receptor protein serine/threonine kinase
728:negative regulation of apoptotic process
656:beta-adrenergic receptor kinase activity
626:protein serine/threonine kinase activity
4985:
4512:Low-density-lipoprotein receptor kinase
1242:
18:
3257:Fas-activated serine/threonine kinase
738:tachykinin receptor signaling pathway
328:
289:
284:
227:
186:
181:
7:
5006:
5004:
4538:Bone morphogenetic protein receptors
3072:Dephospho-(reductase kinase) kinase
2759:The Journal of Biological Chemistry
2598:The Journal of Biological Chemistry
2440:The Journal of Biological Chemistry
2370:The Journal of Biological Chemistry
2265:The Journal of Biological Chemistry
2230:The Journal of Biological Chemistry
1328:Kunapuli P, Benovic JL (Jun 1993).
1127:G protein-coupled receptor kinase 5
5028:. You can help Knowledge (XXG) by
3527:G-protein coupled receptor kinases
1215:Muscarinic acetylcholine receptors
1040:
1019:
993:
972:
948:
929:
903:
884:
858:
839:
546:
464:
402:
381:
14:
3517:Beta adrenergic receptor kinase-2
3202:(tyrosine 3-monooxygenase) kinase
1450:Gurevich VV, Gurevich EV (2019).
1131:G protein-coupled receptor kinase
5008:
4988:
4209:Mitogen-activated protein kinase
1137:, and is most highly similar to
557:
550:
312:
305:
299:
276:
211:
204:
198:
173:
4595:Anti-Müllerian hormone receptor
4478:(acetyl-CoA carboxylase) kinase
4150:(RNA-polymerase)-subunit kinase
3512:Beta adrenergic receptor kinase
3503:Beta adrenergic receptor kinase
2724:Journal of Biological Chemistry
2668:Journal of Biological Chemistry
2633:Journal of Biological Chemistry
2528:Journal of Biological Chemistry
2335:Journal of Biological Chemistry
2300:Journal of Biological Chemistry
2155:Journal of Biological Chemistry
1719:Kunapuli P, Benovic JL (1993).
5085:Human chromosome 10 gene stubs
4218:Extracellular signal-regulated
2197:Cytogenetics and Cell Genetics
568:More reference expression data
530:More reference expression data
1:
4282:P38 mitogen-activated protein
3381:cGMP-dependent protein kinase
3342:cAMP-dependent protein kinase
3038:Pyruvate dehydrogenase kinase
2984:Ataxia telangiectasia mutated
2807:10.1016/S0014-5793(02)02858-2
2278:10.1016/S0021-9258(17)42226-5
2243:10.1016/S0021-9258(17)34046-2
1846:10.1016/S0896-6273(00)81048-X
1784:Pharmacogenetics and Genomics
297:
196:
5075:Genes on human chromosome 10
3081:AMP-activated protein kinase
1796:10.1097/FPC.0b013e32830967e9
3996:(EC 2.7.11.21-EC 2.7.11.30)
1231:angiotensin II AT1 receptor
1151:G protein-coupled receptors
758:protein autophosphorylation
5101:
5003:
3923:Elongation factor 2 kinase
2887:(EC 2.7.11.1-EC 2.7.11.20)
1891:10.1152/ajplung.00255.2003
1406:10.1096/fasebj.9.2.7781920
1207:beta2-adrenergic receptors
1068:Chr 10: 119.21 – 119.46 Mb
4866:Michaelis–Menten kinetics
4625:
4611:
4318:MAP kinase kinase kinases
4001:
3987:
3850:Myosin light-chain kinase
3556:Ca2+/calmodulin-dependent
3221:Myosin-heavy-chain kinase
2892:
2878:
1697:10.1126/scisignal.aar7084
1456:Frontiers in Pharmacology
1311:"Mouse PubMed Reference:"
1293:"Human PubMed Reference:"
1133:subfamily of the Ser/Thr
1113:
1108:
1104:
1097:
1081:
1062:
1047:
1026:
1015:
1000:
979:
968:
955:
951:
936:
932:
923:
910:
906:
891:
887:
878:
865:
861:
846:
842:
833:
818:
811:
807:
791:
586:
582:
565:
549:
540:
527:
476:
467:
414:
405:
375:
367:
363:
346:
333:
296:
275:
266:
262:
245:
232:
195:
172:
163:
159:
114:
111:
101:
94:
89:
66:
61:
44:
39:
34:
30:
26:
21:
4758:Diffusion-limited enzyme
4618:Dual-specificity kinases
2563:Journal of Endocrinology
2496:10.1073/pnas.95.24.14082
2453:10.1074/jbc.273.47.31510
2383:10.1074/jbc.271.23.13796
2348:10.1074/jbc.271.22.13266
2313:10.1074/jbc.271.17.10143
1469:10.3389/fphar.2019.00125
1179:internalization pathways
1171:heterotrimeric G protein
1075:Chr 19: 60.88 – 61.08 Mb
763:fat cell differentiation
743:regulation of cell cycle
646:protein kinase C binding
4041:Cyclin-dependent kinase
2541:10.1074/jbc.274.13.8858
2168:10.1074/jbc.M115.647297
2112:10.1073/pnas.0607583103
2053:10.1073/pnas.93.18.9954
1746:10.1073/pnas.90.12.5588
1646:10.1073/pnas.0904361106
1587:10.1073/pnas.0409534102
1528:10.1073/pnas.0409532102
1355:10.1073/pnas.90.12.5588
1149:the activated forms of
748:protein phosphorylation
611:protein kinase activity
508:myocardium of ventricle
2772:10.1074/jbc.M107297200
2737:10.1074/jbc.M107024200
2681:10.1074/jbc.M002288200
2646:10.1074/jbc.M003542200
1199:functional selectivity
330:19 D3|19 56.52 cM
4851:Eadie–Hofstee diagram
4784:Allosteric regulation
2611:10.1074/jbc.275.1.390
2576:10.1677/joe.0.1620401
733:Wnt signaling pathway
291:Chromosome 19 (mouse)
189:Chromosome 10 (human)
4861:Lineweaver–Burk plot
3884:Phosphorylase kinase
636:phospholipid binding
601:transferase activity
62:List of PDB id codes
35:Available structures
2487:1998PNAS...9514082P
2103:2006PNAS..10316284R
2097:(44): 16284–16289.
2044:1996PNAS...93.9954R
1987:2016NatSR...633231L
1930:2016NatSR...626116H
1737:1993PNAS...90.5588K
1637:2009PNAS..106.9649Z
1578:2005PNAS..102.1448R
1519:2005PNAS..102.1442K
1346:1993PNAS...90.5588K
1219:Alzheimer's disease
1209:, a drug target in
1129:is a member of the
768:signal transduction
5016:This article on a
4820:Enzyme superfamily
4753:Enzyme promiscuity
4495:Tropomyosin kinase
4449:Tau-protein kinase
2418:10.1101/gr.6.9.791
1975:Scientific Reports
1918:Scientific Reports
1153:to regulate their
913:ENSMUSG00000003228
711:Biological process
665:Cellular component
606:nucleotide binding
594:Molecular function
434:lower lobe of lung
5037:
5036:
4976:
4975:
4685:
4684:
4681:
4680:
4677:
4676:
4607:
4606:
4603:
4602:
3983:
3982:
3979:
3978:
3464:Protein kinase N1
3419:Protein kinase Cζ
2376:(23): 13796–803.
2209:10.1159/000134045
2038:(18): 9954–9959.
1995:10.1038/srep33231
1938:10.1038/srep26116
1731:(12): 5588–5592.
1690:(544): eaar7084.
1684:Science Signaling
1631:(24): 9649–9654.
1393:The FASEB Journal
1124:
1123:
1120:
1119:
1093:
1092:
1058:
1057:
1037:
1036:
1011:
1010:
990:
989:
964:
963:
945:
944:
919:
918:
900:
899:
874:
873:
855:
854:
803:
802:
773:apoptotic process
578:
577:
574:
573:
536:
535:
523:
522:
461:
460:
446:synovial membrane
359:
358:
258:
257:
85:
84:
81:
80:
45:Ortholog search:
5092:
5058:
5051:
5044:
5012:
5005:
4993:
4992:
4984:
4856:Hanes–Woolf plot
4799:Enzyme activator
4794:Enzyme inhibitor
4768:Enzyme catalysis
4712:
4705:
4698:
4689:
4627:
4613:
4260:C-Jun N-terminal
4003:
3989:
3493:Rhodopsin kinase
3484:Rhodopsin kinase
3414:Protein kinase C
3405:Protein kinase C
3390:Protein kinase G
3351:Protein kinase A
2962:Protein kinase B
2894:
2880:
2856:
2849:
2842:
2833:
2827:
2809:
2784:
2774:
2749:
2739:
2730:(44): 40431–40.
2714:
2693:
2683:
2674:(35): 27229–37.
2658:
2648:
2639:(34): 26515–22.
2623:
2613:
2588:
2578:
2553:
2543:
2518:
2508:
2498:
2465:
2455:
2430:
2420:
2395:
2385:
2360:
2350:
2341:(22): 13266–72.
2325:
2315:
2290:
2280:
2255:
2245:
2236:(14): 10209–12.
2220:
2190:
2180:
2170:
2161:(34): 20629–47.
2135:
2134:
2124:
2114:
2082:
2076:
2075:
2065:
2055:
2023:
2017:
2016:
2006:
1966:
1960:
1959:
1949:
1909:
1903:
1902:
1885:(2): L312–L319.
1873:
1867:
1866:
1848:
1839:(4): 1029–1036.
1824:
1818:
1817:
1807:
1775:
1769:
1768:
1758:
1748:
1716:
1710:
1709:
1699:
1675:
1669:
1668:
1658:
1648:
1616:
1610:
1609:
1599:
1589:
1572:(5): 1448–1453.
1557:
1551:
1550:
1540:
1530:
1513:(5): 1442–1447.
1498:
1492:
1491:
1481:
1471:
1447:
1441:
1440:
1433:
1427:
1426:
1408:
1384:
1378:
1377:
1367:
1357:
1325:
1319:
1318:
1307:
1301:
1300:
1289:
1283:
1273:
1262:
1252:
1106:
1105:
1077:
1070:
1053:
1041:
1032:
1020:
1016:RefSeq (protein)
1006:
994:
985:
973:
949:
930:
904:
885:
859:
840:
809:
672:nuclear membrane
584:
570:
561:
554:
547:
532:
504:genital tubercle
496:secondary oocyte
472:
470:Top expressed in
465:
410:
408:Top expressed in
403:
382:
365:
355:
342:
331:
316:
309:
303:
292:
280:
264:
254:
241:
230:
215:
208:
202:
191:
177:
161:
155:
153:GRK5 - orthologs
106:
99:
76:
59:
53:
32:
31:
19:
5100:
5099:
5095:
5094:
5093:
5091:
5090:
5089:
5065:
5064:
5063:
5062:
5001:
4999:
4987:
4979:
4977:
4972:
4884:Oxidoreductases
4870:
4846:Enzyme kinetics
4834:
4830:List of enzymes
4803:
4772:
4743:Catalytic triad
4721:
4716:
4686:
4673:
4621:
4599:
4523:
4506:
4489:
4472:
4443:
4303:
4203:
4174:P70-S6 Kinase 1
4144:
4035:
3997:
3975:
3941:
3917:
3878:
3844:
3550:
3521:
3497:
3478:
3399:
3375:
3336:
3292:
3275:
3251:
3245:Aurora C kinase
3240:Aurora B kinase
3235:Aurora A kinase
3215:
3196:
3162:
3133:
3066:
3032:
2888:
2874:
2860:
2830:
2787:
2752:
2717:
2696:
2661:
2626:
2591:
2556:
2534:(13): 8858–64.
2521:
2481:(24): 14082–7.
2468:
2446:(47): 31510–8.
2433:
2405:Genome Research
2398:
2363:
2328:
2306:(17): 10143–8.
2293:
2271:(2): 1099–105.
2258:
2223:
2193:
2148:
2144:
2142:Further reading
2139:
2138:
2084:
2083:
2079:
2025:
2024:
2020:
1968:
1967:
1963:
1911:
1910:
1906:
1875:
1874:
1870:
1826:
1825:
1821:
1777:
1776:
1772:
1718:
1717:
1713:
1677:
1676:
1672:
1618:
1617:
1613:
1559:
1558:
1554:
1500:
1499:
1495:
1449:
1448:
1444:
1435:
1434:
1430:
1386:
1385:
1381:
1340:(12): 5588–92.
1327:
1326:
1322:
1309:
1308:
1304:
1291:
1290:
1286:
1274:
1265:
1253:
1244:
1239:
1175:desensitization
1163:
1135:protein kinases
1115:View/Edit Mouse
1110:View/Edit Human
1073:
1066:
1063:Location (UCSC)
1049:
1028:
1002:
981:
894:ENSG00000198873
787:
718:phosphorylation
706:
682:plasma membrane
660:
631:protein binding
621:kinase activity
566:
556:
555:
528:
519:
514:
510:
506:
502:
498:
494:
490:
486:
482:
468:
457:
452:
448:
444:
440:
436:
432:
428:
424:
420:
406:
350:
337:
329:
319:
318:
317:
310:
290:
267:Gene location (
249:
236:
228:
218:
217:
216:
209:
187:
164:Gene location (
115:
102:
95:
68:
46:
17:
12:
11:
5:
5098:
5096:
5088:
5087:
5082:
5077:
5067:
5066:
5061:
5060:
5053:
5046:
5038:
5035:
5034:
5013:
4998:
4997:
4974:
4973:
4971:
4970:
4957:
4944:
4931:
4918:
4905:
4892:
4878:
4876:
4872:
4871:
4869:
4868:
4863:
4858:
4853:
4848:
4842:
4840:
4836:
4835:
4833:
4832:
4827:
4822:
4817:
4811:
4809:
4808:Classification
4805:
4804:
4802:
4801:
4796:
4791:
4786:
4780:
4778:
4774:
4773:
4771:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4729:
4727:
4723:
4722:
4717:
4715:
4714:
4707:
4700:
4692:
4683:
4682:
4679:
4678:
4675:
4674:
4672:
4671:
4666:
4661:
4656:
4651:
4646:
4641:
4635:
4633:
4623:
4622:
4616:
4609:
4608:
4605:
4604:
4601:
4600:
4598:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4561:
4560:
4555:
4550:
4545:
4534:
4532:
4531:(EC 2.7.11.30)
4525:
4524:
4522:
4521:
4517:
4515:
4514:(EC 2.7.11.29)
4508:
4507:
4505:
4504:
4500:
4498:
4497:(EC 2.7.11.28)
4491:
4490:
4488:
4487:
4483:
4481:
4480:(EC 2.7.11.27)
4474:
4473:
4471:
4470:
4465:
4460:
4454:
4452:
4451:(EC 2.7.11.26)
4445:
4444:
4442:
4441:
4436:
4431:
4430:
4429:
4424:
4419:
4414:
4409:
4404:
4399:
4389:
4388:
4387:
4382:
4377:
4372:
4362:
4361:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4314:
4312:
4311:(EC 2.7.11.25)
4305:
4304:
4302:
4301:
4300:
4299:
4294:
4289:
4279:
4278:
4277:
4272:
4267:
4257:
4256:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4214:
4212:
4211:(EC 2.7.11.24)
4205:
4204:
4202:
4201:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4155:
4153:
4152:(EC 2.7.11.23)
4146:
4145:
4143:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4046:
4044:
4043:(EC 2.7.11.22)
4037:
4036:
4034:
4033:
4028:
4023:
4018:
4012:
4010:
4009:(EC 2.7.11.21)
3999:
3998:
3992:
3985:
3984:
3981:
3980:
3977:
3976:
3974:
3973:
3968:
3963:
3958:
3952:
3950:
3949:(EC 2.7.11.21)
3943:
3942:
3940:
3939:
3934:
3928:
3926:
3925:(EC 2.7.11.20)
3919:
3918:
3916:
3915:
3910:
3905:
3900:
3895:
3889:
3887:
3886:(EC 2.7.11.19)
3880:
3879:
3877:
3876:
3871:
3866:
3861:
3855:
3853:
3852:(EC 2.7.11.18)
3846:
3845:
3843:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3782:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3561:
3559:
3558:(EC 2.7.11.17)
3552:
3551:
3549:
3548:
3543:
3538:
3532:
3530:
3529:(EC 2.7.11.16)
3523:
3522:
3520:
3519:
3514:
3508:
3506:
3505:(EC 2.7.11.15)
3499:
3498:
3496:
3495:
3489:
3487:
3486:(EC 2.7.11.14)
3480:
3479:
3477:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3410:
3408:
3407:(EC 2.7.11.13)
3401:
3400:
3398:
3397:
3392:
3386:
3384:
3383:(EC 2.7.11.12)
3377:
3376:
3374:
3373:
3368:
3363:
3358:
3353:
3347:
3345:
3344:(EC 2.7.11.11)
3338:
3337:
3335:
3334:
3329:
3324:
3319:
3314:
3309:
3303:
3301:
3300:(EC 2.7.11.10)
3294:
3293:
3291:
3290:
3286:
3284:
3277:
3276:
3274:
3273:
3268:
3262:
3260:
3253:
3252:
3250:
3249:
3248:
3247:
3242:
3237:
3226:
3224:
3217:
3216:
3214:
3213:
3207:
3205:
3198:
3197:
3195:
3194:
3189:
3184:
3179:
3173:
3171:
3164:
3163:
3161:
3160:
3155:
3150:
3144:
3142:
3135:
3134:
3132:
3131:
3130:
3129:
3124:
3119:
3111:
3110:
3109:
3104:
3096:
3095:
3094:
3089:
3077:
3075:
3068:
3067:
3065:
3064:
3059:
3054:
3049:
3043:
3041:
3034:
3033:
3031:
3030:
3029:
3028:
3018:
3017:
3016:
3011:
3006:
3001:
2991:
2986:
2981:
2980:
2979:
2974:
2969:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2919:
2914:
2909:
2903:
2901:
2890:
2889:
2883:
2876:
2875:
2861:
2859:
2858:
2851:
2844:
2836:
2829:
2828:
2800:(1–3): 140–4.
2785:
2765:(2): 1607–13.
2750:
2715:
2705:(3): 1243–51.
2694:
2659:
2624:
2589:
2554:
2519:
2466:
2431:
2411:(9): 791–806.
2396:
2361:
2326:
2291:
2256:
2221:
2203:(3–4): 250–4.
2191:
2145:
2143:
2140:
2137:
2136:
2077:
2018:
1961:
1904:
1868:
1819:
1790:(8): 729–732.
1770:
1711:
1670:
1611:
1552:
1493:
1442:
1428:
1399:(2): 175–182.
1379:
1320:
1302:
1284:
1263:
1241:
1240:
1238:
1235:
1233:in the heart.
1195:biased agonism
1162:
1159:
1147:phosphorylates
1145:. The protein
1122:
1121:
1118:
1117:
1112:
1102:
1101:
1095:
1094:
1091:
1090:
1088:
1086:
1079:
1078:
1071:
1064:
1060:
1059:
1056:
1055:
1045:
1044:
1038:
1035:
1034:
1024:
1023:
1017:
1013:
1012:
1009:
1008:
998:
997:
991:
988:
987:
977:
976:
970:
966:
965:
962:
961:
953:
952:
946:
943:
942:
934:
933:
927:
921:
920:
917:
916:
908:
907:
901:
898:
897:
889:
888:
882:
876:
875:
872:
871:
863:
862:
856:
853:
852:
844:
843:
837:
831:
830:
825:
820:
816:
815:
805:
804:
801:
800:
789:
788:
786:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
679:
674:
668:
666:
662:
661:
659:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
597:
595:
591:
590:
580:
579:
576:
575:
572:
571:
563:
562:
544:
538:
537:
534:
533:
525:
524:
521:
520:
518:
517:
513:
509:
505:
501:
497:
493:
492:tail of embryo
489:
485:
481:
477:
474:
473:
462:
459:
458:
456:
455:
451:
447:
443:
442:jejunal mucosa
439:
435:
431:
427:
426:synovial joint
423:
419:
418:saphenous vein
415:
412:
411:
399:
398:
390:
379:
373:
372:
369:RNA expression
361:
360:
357:
356:
348:
344:
343:
335:
332:
327:
321:
320:
311:
304:
298:
294:
293:
288:
282:
281:
273:
272:
260:
259:
256:
255:
247:
243:
242:
234:
231:
226:
220:
219:
210:
203:
197:
193:
192:
185:
179:
178:
170:
169:
157:
156:
113:
109:
108:
100:
92:
91:
87:
86:
83:
82:
79:
78:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5097:
5086:
5083:
5081:
5078:
5076:
5073:
5072:
5070:
5059:
5054:
5052:
5047:
5045:
5040:
5039:
5033:
5031:
5027:
5023:
5022:chromosome 10
5019:
5014:
5011:
5007:
5002:
4996:
4991:
4986:
4982:
4968:
4964:
4963:
4958:
4955:
4951:
4950:
4945:
4942:
4938:
4937:
4932:
4929:
4925:
4924:
4919:
4916:
4912:
4911:
4906:
4903:
4899:
4898:
4893:
4890:
4886:
4885:
4880:
4879:
4877:
4873:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4843:
4841:
4837:
4831:
4828:
4826:
4825:Enzyme family
4823:
4821:
4818:
4816:
4813:
4812:
4810:
4806:
4800:
4797:
4795:
4792:
4790:
4789:Cooperativity
4787:
4785:
4782:
4781:
4779:
4775:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4748:Oxyanion hole
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4730:
4728:
4724:
4720:
4713:
4708:
4706:
4701:
4699:
4694:
4693:
4690:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4636:
4634:
4632:
4628:
4624:
4619:
4614:
4610:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4540:
4539:
4536:
4535:
4533:
4530:
4526:
4519:
4518:
4516:
4513:
4509:
4502:
4501:
4499:
4496:
4492:
4485:
4484:
4482:
4479:
4475:
4469:
4466:
4464:
4461:
4459:
4456:
4455:
4453:
4450:
4446:
4440:
4437:
4435:
4432:
4428:
4425:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4394:
4393:
4390:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4367:
4366:
4363:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4320:
4319:
4316:
4315:
4313:
4310:
4306:
4298:
4295:
4293:
4290:
4288:
4285:
4284:
4283:
4280:
4276:
4273:
4271:
4268:
4266:
4263:
4262:
4261:
4258:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4220:
4219:
4216:
4215:
4213:
4210:
4206:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4156:
4154:
4151:
4147:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4047:
4045:
4042:
4038:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4013:
4011:
4008:
4004:
4000:
3995:
3990:
3986:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3953:
3951:
3948:
3944:
3938:
3935:
3933:
3930:
3929:
3927:
3924:
3920:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3890:
3888:
3885:
3881:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3856:
3854:
3851:
3847:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3562:
3560:
3557:
3553:
3547:
3544:
3542:
3539:
3537:
3534:
3533:
3531:
3528:
3524:
3518:
3515:
3513:
3510:
3509:
3507:
3504:
3500:
3494:
3491:
3490:
3488:
3485:
3481:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3411:
3409:
3406:
3402:
3396:
3393:
3391:
3388:
3387:
3385:
3382:
3378:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3348:
3346:
3343:
3339:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3304:
3302:
3299:
3295:
3288:
3287:
3285:
3283:(EC 2.7.11.9)
3282:
3278:
3272:
3269:
3267:
3264:
3263:
3261:
3259:(EC 2.7.11.8)
3258:
3254:
3246:
3243:
3241:
3238:
3236:
3233:
3232:
3231:
3230:Aurora kinase
3228:
3227:
3225:
3223:(EC 2.7.11.7)
3222:
3218:
3212:
3209:
3208:
3206:
3204:(EC 2.7.11.6)
3203:
3199:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3174:
3172:
3170:(EC 2.7.11.5)
3169:
3165:
3159:
3156:
3154:
3151:
3149:
3146:
3145:
3143:
3141:(EC 2.7.11.4)
3140:
3136:
3128:
3125:
3123:
3120:
3118:
3115:
3114:
3112:
3108:
3105:
3103:
3100:
3099:
3097:
3093:
3090:
3088:
3085:
3084:
3082:
3079:
3078:
3076:
3074:(EC 2.7.11.3)
3073:
3069:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3044:
3042:
3040:(EC 2.7.11.2)
3039:
3035:
3027:
3024:
3023:
3022:
3019:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2996:
2995:
2994:EIF-2 kinases
2992:
2990:
2987:
2985:
2982:
2978:
2975:
2973:
2970:
2968:
2965:
2964:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2904:
2902:
2900:(EC 2.7.11.1)
2899:
2895:
2891:
2886:
2881:
2877:
2872:
2868:
2864:
2857:
2852:
2850:
2845:
2843:
2838:
2837:
2834:
2825:
2821:
2817:
2813:
2808:
2803:
2799:
2795:
2791:
2786:
2782:
2778:
2773:
2768:
2764:
2760:
2756:
2751:
2747:
2743:
2738:
2733:
2729:
2725:
2721:
2716:
2712:
2708:
2704:
2700:
2695:
2691:
2687:
2682:
2677:
2673:
2669:
2665:
2660:
2656:
2652:
2647:
2642:
2638:
2634:
2630:
2625:
2621:
2617:
2612:
2607:
2603:
2599:
2595:
2590:
2586:
2582:
2577:
2572:
2568:
2564:
2560:
2555:
2551:
2547:
2542:
2537:
2533:
2529:
2525:
2520:
2516:
2512:
2507:
2502:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2467:
2463:
2459:
2454:
2449:
2445:
2441:
2437:
2432:
2428:
2424:
2419:
2414:
2410:
2406:
2402:
2397:
2393:
2389:
2384:
2379:
2375:
2371:
2367:
2362:
2358:
2354:
2349:
2344:
2340:
2336:
2332:
2327:
2323:
2319:
2314:
2309:
2305:
2301:
2297:
2292:
2288:
2284:
2279:
2274:
2270:
2266:
2262:
2257:
2253:
2249:
2244:
2239:
2235:
2231:
2227:
2222:
2218:
2214:
2210:
2206:
2202:
2198:
2192:
2188:
2184:
2179:
2174:
2169:
2164:
2160:
2156:
2152:
2147:
2146:
2141:
2132:
2128:
2123:
2118:
2113:
2108:
2104:
2100:
2096:
2092:
2088:
2081:
2078:
2073:
2069:
2064:
2059:
2054:
2049:
2045:
2041:
2037:
2033:
2029:
2022:
2019:
2014:
2010:
2005:
2000:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1965:
1962:
1957:
1953:
1948:
1943:
1939:
1935:
1931:
1927:
1923:
1919:
1915:
1908:
1905:
1900:
1896:
1892:
1888:
1884:
1880:
1872:
1869:
1864:
1860:
1856:
1852:
1847:
1842:
1838:
1834:
1830:
1823:
1820:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1785:
1781:
1774:
1771:
1766:
1762:
1757:
1752:
1747:
1742:
1738:
1734:
1730:
1726:
1722:
1715:
1712:
1707:
1703:
1698:
1693:
1689:
1685:
1681:
1674:
1671:
1666:
1662:
1657:
1652:
1647:
1642:
1638:
1634:
1630:
1626:
1622:
1615:
1612:
1607:
1603:
1598:
1593:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1556:
1553:
1548:
1544:
1539:
1534:
1529:
1524:
1520:
1516:
1512:
1508:
1504:
1497:
1494:
1489:
1485:
1480:
1475:
1470:
1465:
1461:
1457:
1453:
1446:
1443:
1438:
1432:
1429:
1424:
1420:
1416:
1412:
1407:
1402:
1398:
1394:
1390:
1383:
1380:
1375:
1371:
1366:
1361:
1356:
1351:
1347:
1343:
1339:
1335:
1331:
1324:
1321:
1316:
1312:
1306:
1303:
1298:
1294:
1288:
1285:
1281:
1277:
1272:
1270:
1268:
1264:
1260:
1256:
1251:
1249:
1247:
1243:
1236:
1234:
1232:
1228:
1227:organogenesis
1224:
1220:
1216:
1212:
1208:
1202:
1200:
1197:(also called
1196:
1192:
1188:
1182:
1180:
1176:
1172:
1168:
1160:
1158:
1156:
1152:
1148:
1144:
1140:
1136:
1132:
1128:
1116:
1111:
1107:
1103:
1100:
1096:
1089:
1087:
1084:
1080:
1076:
1072:
1069:
1065:
1061:
1054:
1052:
1046:
1042:
1039:
1033:
1031:
1025:
1021:
1018:
1014:
1007:
1005:
999:
995:
992:
986:
984:
978:
974:
971:
969:RefSeq (mRNA)
967:
960:
959:
954:
950:
947:
941:
940:
935:
931:
928:
926:
922:
915:
914:
909:
905:
902:
896:
895:
890:
886:
883:
881:
877:
870:
869:
864:
860:
857:
851:
850:
845:
841:
838:
836:
832:
829:
826:
824:
821:
817:
814:
810:
806:
799:
795:
790:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
702:nuclear speck
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
669:
667:
664:
663:
657:
654:
652:
651:lipid binding
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
598:
596:
593:
592:
589:
588:Gene ontology
585:
581:
569:
564:
560:
553:
548:
545:
543:
539:
531:
526:
515:
511:
507:
503:
500:Gonadal ridge
499:
495:
491:
487:
483:
479:
478:
475:
471:
466:
463:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
416:
413:
409:
404:
401:
400:
397:
395:
391:
389:
388:
384:
383:
380:
378:
374:
370:
366:
362:
354:
349:
345:
341:
336:
326:
322:
315:
308:
302:
295:
287:
283:
279:
274:
270:
265:
261:
253:
248:
244:
240:
235:
225:
221:
214:
207:
201:
194:
190:
184:
180:
176:
171:
167:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
110:
105:
98:
93:
88:
77:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
5030:expanding it
5015:
5000:
4962:Translocases
4959:
4946:
4933:
4920:
4907:
4897:Transferases
4894:
4881:
4738:Binding site
4169:P70S6 kinase
3540:
2797:
2794:FEBS Letters
2793:
2762:
2758:
2727:
2723:
2702:
2698:
2671:
2667:
2636:
2632:
2604:(1): 390–7.
2601:
2597:
2569:(3): 401–8.
2566:
2562:
2531:
2527:
2478:
2474:
2443:
2439:
2408:
2404:
2373:
2369:
2338:
2334:
2303:
2299:
2268:
2264:
2233:
2229:
2200:
2196:
2158:
2154:
2094:
2090:
2080:
2035:
2031:
2021:
1978:
1974:
1964:
1921:
1917:
1907:
1882:
1878:
1871:
1836:
1832:
1822:
1787:
1783:
1773:
1728:
1724:
1714:
1687:
1683:
1673:
1628:
1624:
1614:
1569:
1565:
1555:
1510:
1506:
1496:
1459:
1455:
1445:
1431:
1396:
1392:
1382:
1337:
1333:
1323:
1314:
1305:
1296:
1287:
1203:
1183:
1164:
1126:
1125:
1048:
1027:
1001:
980:
956:
937:
911:
892:
866:
847:
827:
822:
392:
385:
250:119,459,745
237:119,207,571
112:External IDs
67:
4733:Active site
4620:(EC 2.7.12)
4007:Polo kinase
3947:Polo kinase
641:ATP binding
488:granulocyte
438:pericardium
351:61,084,406
338:60,878,187
90:Identifiers
5069:Categories
4936:Isomerases
4910:Hydrolases
4777:Regulation
3298:IκB kinase
2873:2.7.11-12)
1282:, May 2017
1261:, May 2017
1237:References
1223:heterotaxy
454:right lung
396:(ortholog)
133:HomoloGene
5080:EC 2.7.11
5020:on human
4815:EC number
3424:PKC alpha
1981:: 33231.
1924:: 26116.
1155:signaling
1051:NP_061357
1030:NP_005299
1004:NM_018869
983:NM_005308
813:Orthologs
692:cytoplasm
512:esophagus
141:GeneCards
4839:Kinetics
4763:Cofactor
4726:Activity
3780:KIAA0999
3675:MAPKAPK5
3670:MAPKAPK3
3665:MAPKAPK2
2824:29467488
2816:12067742
2781:11700307
2746:11517230
2711:11504827
2690:10858434
2655:10852916
2620:10617630
2585:10467231
2550:10085129
2187:26032409
2131:17060617
2013:27618959
1956:27193825
1899:14565944
1855:10624964
1814:18622265
1706:30131371
1665:19497875
1606:15671180
1547:15671181
1488:30837883
1423:20428064
1278:–
1257:–
1167:arrestin
1161:Function
1099:Wikidata
792:Sources:
677:membrane
229:10q26.11
4995:Biology
4949:Ligases
4719:Enzymes
4439:MAP3K14
4417:MAP3K11
4412:MAP3K10
4402:MAP3K13
4397:MAP3K12
4199:RPS6KC1
4194:RPS6KA1
4189:RPS6KA3
4184:RPS6KA2
4179:RPS6KB2
4164:RPS6KA4
4159:RPS6KA5
3810:Kalirin
3775:SNF1LK2
3014:EIF2AK4
3009:EIF2AK3
2863:Kinases
2515:9826657
2483:Bibcode
2462:9813065
2427:8889548
2392:8662852
2357:8662816
2322:8626574
2287:8288567
2252:8144599
2217:7789183
2178:4543624
2122:1637574
2099:Bibcode
2072:8790438
2040:Bibcode
2004:5020398
1983:Bibcode
1947:4872166
1926:Bibcode
1863:7788715
1805:2699179
1765:7685906
1733:Bibcode
1656:2689814
1633:Bibcode
1574:Bibcode
1515:Bibcode
1479:6389790
1462:: 125.
1415:7781920
1374:7685906
1342:Bibcode
1280:Ensembl
1259:Ensembl
925:UniProt
880:Ensembl
819:Species
798:QuickGO
697:cytosol
687:nucleus
450:urethra
422:pylorus
371:pattern
97:Aliases
4981:Portal
4923:Lyases
4669:MAP2K7
4664:MAP2K6
4659:MAP2K5
4654:MAP2K4
4649:MAP2K3
4644:MAP2K2
4639:MAP2K1
4590:ACVRL1
4585:ACVR2B
4580:ACVR2A
4575:ACVR1C
4570:ACVR1B
4553:BMPR1B
4548:BMPR1A
4422:MAP3K7
4407:MAP3K9
4358:MAP3K8
4353:MAP3K7
4348:MAP3K6
4343:MAP3K5
4338:MAP3K4
4333:MAP3K3
4328:MAP3K2
4323:MAP3K1
4297:MAPK14
4292:MAPK13
4287:MAPK11
4275:MAPK10
4253:MAPK15
4248:MAPK12
4140:CDC2L1
4115:CDC2L5
3790:SNF1LK
3615:CAMK2G
3610:CAMK2D
3605:CAMK2B
3600:CAMK2A
3590:CAMK1G
3585:CAMK1D
3580:CAMK1B
3575:CAMK1A
3429:PRKCB1
3366:PRKACA
3361:PRKACB
3356:PRKACG
3332:IKBKAP
3158:BCKDHB
3153:BCKDHA
3127:PRKAG3
3122:PRKAG2
3117:PRKAG1
3107:PRKAB2
3102:PRKAB1
3092:PRKAA2
3087:PRKAA1
2932:STK38L
2822:
2814:
2779:
2744:
2709:
2688:
2653:
2618:
2583:
2548:
2513:
2503:
2460:
2425:
2390:
2355:
2320:
2285:
2250:
2215:
2185:
2175:
2129:
2119:
2070:
2060:
2011:
2001:
1954:
1944:
1897:
1861:
1853:
1833:Neuron
1812:
1802:
1763:
1753:
1704:
1663:
1653:
1604:
1597:547876
1594:
1545:
1538:547874
1535:
1486:
1476:
1421:
1413:
1372:
1362:
1211:asthma
1085:search
1083:PubMed
958:Q8VEB1
939:P34947
835:Entrez
542:BioGPS
516:morula
484:zygote
430:cardia
129:109161
121:600870
5024:is a
4875:Types
4631:MAP2K
4565:ACVR1
4558:BMPR2
4543:BMPR1
4468:GSK-3
4309:MAP3K
4270:MAPK9
4265:MAPK8
4243:MAPK7
4238:MAPK6
4233:MAPK4
4228:MAPK3
4223:MAPK1
4135:PFTK1
4130:PCTK3
4125:PCTK2
4120:PCTK1
4110:CDK12
4105:CDK10
4080:CDKL5
4060:CDKL2
3937:STK19
3932:EEF2K
3913:PHKG2
3908:PHKG1
3898:PHKA2
3893:PHKA1
3874:MYLK4
3869:MYLK3
3864:MYLK2
3840:DCLK1
3835:Titin
3825:TRIB3
3820:TRIB2
3815:TRIB1
3805:TSSK2
3785:STK40
3770:PSKH1
3765:PRKD3
3760:PRKD2
3740:PHKG2
3735:PHKG1
3725:OBSCN
3720:NUAK2
3715:NUAK1
3710:MKNK2
3705:MKNK1
3695:MARK4
3690:MARK3
3685:MARK2
3680:MARK1
3660:STK11
3655:DAPK3
3650:DAPK2
3645:DAPK1
3640:CHEK2
3635:CHEK1
3620:CAMK4
3595:CAMK2
3570:CAMK1
3565:BRSK2
3459:PRKCQ
3454:PRKCI
3449:PRKCG
3444:PRKCH
3439:PRKCE
3434:PRKCD
3395:PRKG1
3327:IKBKG
3322:IKBKE
3271:STK10
3266:FASTK
3192:IDH3G
3187:IDH3B
3182:IDH3A
3148:BCKDK
2942:ROCK1
2927:STK38
2922:MAST2
2917:MAST1
2912:LATS2
2907:LATS1
2820:S2CID
2506:24330
2063:38536
1859:S2CID
1756:46766
1419:S2CID
1365:46766
868:14773
828:Mouse
823:Human
794:Amigo
480:blood
394:Mouse
387:Human
334:Start
269:Mouse
233:Start
166:Human
5026:stub
5018:gene
4967:list
4960:EC7
4954:list
4947:EC6
4941:list
4934:EC5
4928:list
4921:EC4
4915:list
4908:EC3
4902:list
4895:EC2
4889:list
4882:EC1
4458:TPK1
4434:CDC7
4392:MLKs
4385:KSR2
4380:KSR1
4375:BRAF
4370:ARAF
4365:RAFs
4100:CDK9
4095:CDK8
4090:CDK7
4085:CDK6
4075:CDK5
4070:CDK4
4065:CDK3
4055:CDK2
4050:CDK1
4031:PLK4
4026:PLK3
4021:PLK2
4016:PLK1
3971:PLK4
3966:PLK3
3961:PLK2
3956:PLK1
3903:PHKB
3859:MYLK
3830:TRIO
3800:SPEG
3795:SNRK
3755:PKD1
3750:PIM2
3745:PIM1
3730:PASK
3700:MELK
3630:CASK
3625:MLCK
3546:GRK6
3541:GRK5
3536:GRK4
3474:PKN3
3469:PKN2
3371:PRKY
3317:TBK1
3312:IKK2
3307:CHUK
3211:STK4
3177:IDH2
3062:PDK4
3057:PDK3
3052:PDK2
3047:PDK1
3026:WEE1
3021:Wee1
2989:mTOR
2977:AKT3
2972:AKT2
2967:AKT1
2957:SGK3
2952:SGK2
2812:PMID
2777:PMID
2742:PMID
2707:PMID
2686:PMID
2651:PMID
2616:PMID
2581:PMID
2546:PMID
2511:PMID
2458:PMID
2423:PMID
2388:PMID
2353:PMID
2318:PMID
2283:PMID
2248:PMID
2213:PMID
2183:PMID
2127:PMID
2068:PMID
2009:PMID
1952:PMID
1895:PMID
1851:PMID
1810:PMID
1761:PMID
1702:PMID
1661:PMID
1602:PMID
1543:PMID
1484:PMID
1411:PMID
1370:PMID
1191:GRK3
1189:and
1187:GRK2
1143:GRK6
1141:and
1139:GRK4
849:2869
377:Bgee
325:Band
286:Chr.
224:Band
183:Chr.
145:GRK5
137:3879
117:OMIM
104:GRK5
74:4TND
70:4TNB
51:RCSB
48:PDBe
22:GRK5
4463:TTK
4427:ZAK
3004:HRI
2999:PKR
2947:SGK
2937:CIT
2802:doi
2798:521
2767:doi
2763:277
2732:doi
2728:276
2703:298
2676:doi
2672:275
2641:doi
2637:275
2606:doi
2602:275
2571:doi
2567:162
2536:doi
2532:274
2501:PMC
2491:doi
2448:doi
2444:273
2413:doi
2378:doi
2374:271
2343:doi
2339:271
2308:doi
2304:271
2273:doi
2269:269
2238:doi
2234:269
2205:doi
2173:PMC
2163:doi
2159:290
2117:PMC
2107:doi
2095:103
2058:PMC
2048:doi
1999:PMC
1991:doi
1942:PMC
1934:doi
1887:doi
1883:286
1841:doi
1800:PMC
1792:doi
1751:PMC
1741:doi
1692:doi
1651:PMC
1641:doi
1629:106
1592:PMC
1582:doi
1570:102
1533:PMC
1523:doi
1511:102
1474:PMC
1464:doi
1401:doi
1360:PMC
1350:doi
347:End
246:End
149:OMA
125:MGI
41:PDB
5071::
3113:γ
3098:β
3083:α
2871:EC
2865::
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