306:
283:
180:
205:
1336:
1321:
312:
211:
29:
1361:
55:
1038:
The two main amino acids in the enzyme active site are Glu 304, which acts as a
Bronsted-Lowry base and abstracts a proton, and His 170, which acts as Bronsted-Lowry Acid to donate a proton to the galactose.
319:
218:
1335:
746:
727:
141:
1430:
1116:
1098:
1406:
1300:
1320:
1425:
305:
52:
953:
946:
282:
1085:
1064:
1275:
provides an overview of all the structure information available in the PDB for Human Aldose 1-epimerase (Galactose mutarotase)
1081:
204:
179:
1060:
121:
318:
217:
1399:
1293:
311:
210:
791:
129:
772:
112:, BLOCK25, GLAT, HEL-S-63p, IBD1, galactose mutarotase (aldose 1-epimerase), galactose mutarotase, GALAC4
1392:
1286:
193:
108:
153:
929:
908:
882:
861:
1251:
1202:
1157:
101:
45:
1376:
1241:
1233:
1192:
1147:
398:
329:
273:
228:
373:
149:
1246:
1221:
1025:
661:
656:
651:
646:
641:
625:
620:
599:
594:
589:
28:
1419:
1272:
576:
133:
1372:
1176:
391:
170:
1181:"Structure and function of enzymes of the Leloir pathway for galactose metabolism"
157:
1121:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1103:
National Center for
Biotechnology Information, U.S. National Library of Medicine
474:
290:
187:
137:
1032:
691:
534:
412:
357:
344:
256:
243:
145:
1255:
1206:
1197:
1180:
1161:
1152:
1135:
1344:: Crystal structure of human galactose mutarotase complexed with galactose
993:
988:
977:
836:
817:
604:
1237:
803:
758:
78:
74:
1029:
1028:, which is involved in galactose metabolism. It belongs to family of
1021:
1017:
1013:
961:
713:
1360:
676:
672:
1368:
125:
1282:
1278:
381:
1380:
1134:
Thoden JB, Timson DJ, Reece RJ, Holden HM (May 2004).
1329:: Crystal structure of apo human galactose mutarotase
546:
1220:
Thoden JB, Kim J, Raushel FM, Holden HM (May 2003).
1136:"Molecular structure of human galactose mutarotase"
922:
901:
875:
854:
1077:
1075:
1073:
1056:
1054:
1052:
1222:"The catalytic mechanism of galactose mutarotase"
328:
227:
16:Protein-coding gene in the species Homo sapiens
1082:GRCm38: Ensembl release 89: ENSMUSG00000035473
1024:. This enzyme catalyzes the first step of the
1400:
1294:
657:galactose catabolic process via UDP-galactose
8:
1061:GRCh38: Ensembl release 89: ENSG00000143891
1407:
1393:
1301:
1287:
1279:
687:
572:
369:
268:
165:
63:
1245:
1196:
1151:
1006:Galactose mutarotase (aldose 1-epimerase)
1316:
1048:
18:
333:
294:
289:
232:
191:
186:
7:
1357:
1355:
493:vestibular membrane of cochlear duct
1185:The Journal of Biological Chemistry
1140:The Journal of Biological Chemistry
1379:. You can help Knowledge (XXG) by
919:
898:
872:
851:
827:
808:
782:
763:
737:
718:
551:
469:
407:
386:
14:
1359:
1334:
1319:
317:
310:
304:
281:
216:
209:
203:
178:
27:
662:carbohydrate metabolic process
535:More reference expression data
1:
1431:Human chromosome 2 gene stubs
1179:, Thoden JB (November 2003).
302:
201:
1426:Genes on human chromosome 2
1016:that reversibly converts α-
652:galactose metabolic process
595:aldose 1-epimerase activity
1447:
1354:
521:superior surface of tongue
1314:
1117:"Mouse PubMed Reference:"
1099:"Human PubMed Reference:"
992:
987:
983:
976:
960:
941:
926:
905:
894:
879:
858:
847:
834:
830:
815:
811:
802:
789:
785:
770:
766:
757:
744:
740:
725:
721:
712:
697:
690:
686:
670:
647:glucose metabolic process
575:
571:
559:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
954:Chr 17: 80.43 – 80.49 Mb
642:hexose metabolic process
947:Chr 2: 38.67 – 38.74 Mb
1198:10.1074/jbc.R300025200
1153:10.1074/jbc.M402347200
431:pancreatic ductal cell
621:extracellular exosome
501:epithelium of stomach
296:Chromosome 17 (mouse)
600:carbohydrate binding
485:olfactory epithelium
427:right adrenal cortex
194:Chromosome 2 (human)
67:List of PDB id codes
40:Available structures
1191:(45): 43885–43888.
1146:(22): 23431–23437.
439:left adrenal cortex
423:right adrenal gland
1367:This article on a
1238:10.1110/ps.0243203
792:ENSMUSG00000035473
635:Biological process
614:Cellular component
605:catalytic activity
590:isomerase activity
583:Molecular function
497:left lobe of liver
447:right uterine tube
435:left adrenal gland
1388:
1387:
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1351:
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1002:
999:
998:
972:
971:
937:
936:
916:
915:
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842:
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823:
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778:
753:
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734:
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682:
681:
567:
566:
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562:
541:
540:
528:
527:
466:
465:
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
1438:
1409:
1402:
1395:
1363:
1356:
1338:
1323:
1303:
1296:
1289:
1280:
1260:
1259:
1249:
1232:(5): 1051–1059.
1217:
1211:
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1166:
1165:
1155:
1131:
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1113:
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1089:
1079:
1068:
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911:
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895:RefSeq (protein)
885:
873:
864:
852:
828:
809:
783:
764:
738:
719:
688:
573:
552:
537:
477:
475:Top expressed in
470:
415:
413:Top expressed in
408:
387:
370:
360:
347:
336:
321:
314:
308:
297:
285:
269:
259:
246:
235:
220:
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207:
196:
182:
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158:GALM - orthologs
111:
104:
81:
64:
58:
37:
36:
31:
19:
1446:
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1440:
1439:
1437:
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1353:
1348:
1345:
1339:
1330:
1324:
1310:
1307:
1269:
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1226:Protein Science
1219:
1218:
1214:
1174:
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1128:
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1110:
1097:
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1092:
1080:
1071:
1059:
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994:View/Edit Mouse
989:View/Edit Human
952:
945:
942:Location (UCSC)
928:
907:
881:
860:
773:ENSG00000143891
666:
630:
609:
533:
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519:
515:
511:
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487:
473:
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355:
342:
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315:
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272:Gene location (
254:
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169:Gene location (
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73:
51:
17:
12:
11:
5:
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1325:
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1267:External links
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1026:Leloir pathway
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517:primary oocyte
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489:lacrimal gland
486:
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467:
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455:jejunal mucosa
452:
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440:
436:
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384:
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374:RNA expression
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32:
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13:
10:
9:
6:
4:
3:
2:
1443:
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1199:
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1182:
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1159:
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1137:
1130:
1127:
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1118:
1112:
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1094:
1091:
1087:
1083:
1078:
1076:
1074:
1070:
1066:
1062:
1057:
1055:
1053:
1049:
1042:
1040:
1036:
1034:
1031:
1027:
1023:
1019:
1015:
1012:) is a human
1011:
1007:
995:
990:
986:
982:
979:
975:
968:
966:
963:
959:
955:
951:
948:
944:
940:
933:
931:
925:
921:
918:
912:
910:
904:
900:
897:
893:
886:
884:
878:
874:
871:
865:
863:
857:
853:
850:
848:RefSeq (mRNA)
846:
839:
838:
833:
829:
826:
820:
819:
814:
810:
807:
805:
801:
794:
793:
788:
784:
781:
775:
774:
769:
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762:
760:
756:
749:
748:
743:
739:
736:
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729:
724:
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612:
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603:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
483:
480:
476:
471:
468:
458:
454:
451:renal medulla
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
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393:
389:
388:
385:
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371:
367:
359:
354:
350:
346:
341:
335:17|17 E3
331:
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82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1381:expanding it
1373:chromosome 2
1366:
1341:
1326:
1229:
1225:
1215:
1188:
1184:
1170:
1143:
1139:
1129:
1120:
1111:
1102:
1093:
1037:
1009:
1005:
1004:
927:
906:
880:
859:
835:
816:
790:
771:
745:
726:
706:
701:
513:right kidney
459:human kidney
397:
390:
117:External IDs
72:
1309:PDB gallery
1175:Holden HM,
1008:(gene name
509:gallbladder
356:80,492,530
343:80,434,900
255:38,741,237
242:38,666,081
95:Identifiers
1420:Categories
1088:, May 2017
1067:, May 2017
1043:References
1033:epimerases
401:(ortholog)
138:HomoloGene
1371:on human
1177:Rayment I
1020:to the β-
930:NP_795937
909:NP_620156
883:NM_176963
862:NM_138801
692:Orthologs
626:cytoplasm
146:GeneCards
1256:12717027
1207:12923184
1162:15026423
1084:–
1063:–
978:Wikidata
671:Sources:
443:duodenum
1273:PDBe-KB
1247:2323875
1086:Ensembl
1065:Ensembl
804:UniProt
759:Ensembl
698:Species
677:QuickGO
505:jejunum
376:pattern
134:2442420
102:Aliases
1254:
1244:
1205:
1160:
1030:aldose
1022:anomer
1018:aldose
1014:enzyme
964:search
962:PubMed
837:Q8K157
818:Q96C23
747:319625
728:130589
714:Entrez
547:BioGPS
234:2p22.1
126:137030
1375:is a
707:Mouse
702:Human
673:Amigo
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
142:71795
1377:stub
1369:gene
1342:1so0
1327:1snz
1252:PMID
1203:PMID
1158:PMID
1010:GALM
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
150:GALM
122:OMIM
109:GALM
79:1SO0
75:1SNZ
56:RCSB
53:PDBe
22:GALM
1242:PMC
1234:doi
1193:doi
1189:278
1148:doi
1144:279
555:n/a
352:End
251:End
154:OMA
130:MGI
46:PDB
1422::
1250:.
1240:.
1230:12
1228:.
1224:.
1201:.
1187:.
1183:.
1156:.
1142:.
1138:.
1119:.
1101:.
1072:^
1051:^
1035:.
675:/
358:bp
345:bp
257:bp
244:bp
152:;
148::
144:;
140::
136:;
132::
128:;
124::
77:,
1408:e
1401:t
1394:v
1383:.
1302:e
1295:t
1288:v
1258:.
1236::
1209:.
1195::
1164:.
1150::
1123:.
1105:.
276:)
173:)
156::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
