Knowledge (XXG)

Galactosyltransferase

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168:) and related proteins into distinct sequence based families has been described. This classification is available on the CAZy (Carbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'. 129: 1593: 160:
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of
738: 733: 154: 1111: 987: 778: 96: 1092: 1160: 609: 1269: 1239: 1664: 914: 909: 1274: 602: 494:"Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains" 1312: 1155: 1165: 1186: 1170: 1468: 535:"Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes" 116: 1657: 595: 1583: 705: 175:) comprises enzymes with a number of known activities; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase ( 690: 1130: 1453: 1569: 1556: 1543: 1530: 1517: 1504: 1491: 1255: 1147: 1060: 695: 635: 1463: 1650: 1417: 1360: 700: 673: 626: 581: 413:"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities" 197: 190: 183: 176: 162: 104: 1365: 1190: 753: 668: 161:
glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (
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Henrissat B, Coutinho PM (1999). "Carbohydrate-Active Enzymes server".
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Hennet T, Dinter A, Kuhnert P, Mattu TS, Rudd PM, Berger EG (1998).
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Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
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B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
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B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
189:); fucose-specific beta-1,3-N-acetylglucosaminyltransferase ( 1290: 1638: 1604:
This article incorporates text from the public domain
988:
Dolichyl-phosphate-mannose-protein mannosyltransferase
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Henrissat B, Davies GJ, Campbell JA, Bulone V (1997).
1581: 196:); globotriosylceramide beta-1,3-GalNAc transferase ( 1477: 1441: 1410: 1379: 1328: 1254: 1210: 1179: 1146: 1083: 1074: 1059: 978: 900: 752: 719: 649: 634: 110: 90: 72: 67: 51: 39: 31: 26: 21: 1161:Hypoxanthine-guanine phosphoribosyltransferase 492:Kolbinger F, Streiff MB, Katopodis AG (1998). 1658: 1306: 603: 8: 1270:Beta-galactoside alpha-2,6-sialyltransferase 1240:Indolylacetylinositol arabinosyltransferase 1665: 1651: 1313: 1299: 1291: 1080: 1071: 646: 610: 596: 588: 64: 580:at the U.S. National Library of Medicine 550: 509: 436: 1588: 403: 1275:Monosialoganglioside sialyltransferase 1112:NAD(P):arginine ADP-ribosyltransferase 1093:NAD:diphthamide ADP-ribosyltransferase 474: 463: 18: 7: 1623: 1621: 182:); beta-1,3-galactosyltransferase ( 1637:. You can help Knowledge (XXG) by 14: 1156:Adenine phosphoribosyltransferase 1591: 1166:Uracil phosphoribosyltransferase 1187:Purine nucleoside phosphorylase 171:Glycosyltransferase family 31 ( 1171:Amidophosphoribosyltransferase 1: 68:Available protein structures: 706:Ceramide glucosyltransferase 207:Human galactosyltransferases 1710: 1620: 1603: 1131:Poly ADP ribose polymerase 1469:Michaelis–Menten kinetics 1148:Phosphoribosyltransferase 63: 1361:Diffusion-limited enzyme 701:1,3-Beta-glucan synthase 582:Medical Subject Headings 1191:Thymidine phosphorylase 1633:-related article is a 1085:ADP-ribosyltransferase 578:Galactosyltransferases 473:Cite journal requires 135: 1454:Eadie–Hofstee diagram 1387:Allosteric regulation 1235:Arabinosyltransferase 711:N-glycosyltransferase 511:10.1074/jbc.273.1.433 139:Galactosyltransferase 131: 22:Galactosyltransferase 1464:Lineweaver–Burk plot 1103:Pseudomonas exotoxin 623:glycosyltransferases 552:10.1074/jbc.273.1.58 878:Hyaluronan synthase 143:glycosyltransferase 1423:Enzyme superfamily 1356:Enzyme promiscuity 1218:Xylosyltransferase 691:Debranching enzyme 429:10.1042/bj3260929u 136: 1646: 1645: 1579: 1578: 1288: 1287: 1250: 1249: 1206: 1205: 1055: 1054: 686:Glycogen synthase 126: 125: 122: 121: 117:structure summary 1701: 1667: 1660: 1653: 1622: 1596: 1595: 1587: 1459:Hanes–Woolf plot 1402:Enzyme activator 1397:Enzyme inhibitor 1371:Enzyme catalysis 1315: 1308: 1301: 1292: 1098:Diphtheria toxin 1081: 1072: 729:Lactose synthase 696:Branching enzyme 647: 612: 605: 598: 589: 565: 564: 554: 530: 524: 523: 513: 489: 483: 482: 476: 471: 469: 461: 457: 451: 450: 440: 408: 153:. An example is 149:the transfer of 65: 19: 16:Class of enzymes 1709: 1708: 1704: 1703: 1702: 1700: 1699: 1698: 1674: 1673: 1672: 1671: 1618: 1616: 1602: 1590: 1582: 1580: 1575: 1487:Oxidoreductases 1473: 1449:Enzyme kinetics 1437: 1433:List of enzymes 1406: 1375: 1346:Catalytic triad 1324: 1319: 1289: 1284: 1261: 1246: 1202: 1175: 1142: 1117:Pertussis toxin 1066: 1051: 974: 896: 748: 715: 641: 630: 616: 574: 569: 568: 532: 531: 527: 491: 490: 486: 472: 462: 459: 458: 454: 410: 409: 405: 400: 209: 17: 12: 11: 5: 1707: 1705: 1697: 1696: 1691: 1686: 1676: 1675: 1670: 1669: 1662: 1655: 1647: 1644: 1643: 1601: 1600: 1577: 1576: 1574: 1573: 1560: 1547: 1534: 1521: 1508: 1495: 1481: 1479: 1475: 1474: 1472: 1471: 1466: 1461: 1456: 1451: 1445: 1443: 1439: 1438: 1436: 1435: 1430: 1425: 1420: 1414: 1412: 1411:Classification 1408: 1407: 1405: 1404: 1399: 1394: 1389: 1383: 1381: 1377: 1376: 1374: 1373: 1368: 1363: 1358: 1353: 1348: 1343: 1338: 1332: 1330: 1326: 1325: 1320: 1318: 1317: 1310: 1303: 1295: 1286: 1285: 1283: 1282: 1277: 1272: 1266: 1264: 1252: 1251: 1248: 1247: 1245: 1244: 1243: 1242: 1232: 1231: 1230: 1225: 1214: 1212: 1208: 1207: 1204: 1203: 1201: 1200: 1199: 1198: 1183: 1181: 1177: 1176: 1174: 1173: 1168: 1163: 1158: 1152: 1150: 1144: 1143: 1141: 1140: 1134: 1133: 1127: 1126: 1125: 1124: 1119: 1108: 1107: 1106: 1105: 1100: 1089: 1087: 1078: 1069: 1057: 1056: 1053: 1052: 1050: 1049: 1044: 1039: 1034: 1029: 1024: 1019: 1013: 1012: 1007: 1002: 1001: 1000: 995: 984: 982: 976: 975: 973: 972: 967: 962: 957: 952: 947: 942: 937: 932: 927: 922: 917: 912: 906: 904: 898: 897: 895: 894: 889: 884: 874: 873: 868: 863: 858: 853: 848: 843: 838: 833: 828: 822: 821: 816: 811: 806: 801: 796: 791: 786: 781: 775: 774: 769: 764: 758: 756: 750: 749: 747: 746: 736: 731: 725: 723: 717: 716: 714: 713: 708: 703: 698: 693: 688: 683: 682: 681: 676: 671: 666: 655: 653: 644: 632: 631: 617: 615: 614: 607: 600: 592: 586: 585: 573: 572:External links 570: 567: 566: 525: 504:(1): 433–440. 484: 475:|journal= 452: 423:(3): 929–939. 402: 401: 399: 396: 208: 205: 124: 123: 120: 119: 114: 108: 107: 94: 88: 87: 77: 70: 69: 61: 60: 55: 49: 48: 43: 37: 36: 33: 29: 28: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1706: 1695: 1692: 1690: 1687: 1685: 1682: 1681: 1679: 1668: 1663: 1661: 1656: 1654: 1649: 1648: 1642: 1640: 1636: 1632: 1629: 1624: 1619: 1615: 1611: 1607: 1599: 1594: 1589: 1585: 1571: 1567: 1566: 1561: 1558: 1554: 1553: 1548: 1545: 1541: 1540: 1535: 1532: 1528: 1527: 1522: 1519: 1515: 1514: 1509: 1506: 1502: 1501: 1496: 1493: 1489: 1488: 1483: 1482: 1480: 1476: 1470: 1467: 1465: 1462: 1460: 1457: 1455: 1452: 1450: 1447: 1446: 1444: 1440: 1434: 1431: 1429: 1428:Enzyme family 1426: 1424: 1421: 1419: 1416: 1415: 1413: 1409: 1403: 1400: 1398: 1395: 1393: 1392:Cooperativity 1390: 1388: 1385: 1384: 1382: 1378: 1372: 1369: 1367: 1364: 1362: 1359: 1357: 1354: 1352: 1351:Oxyanion hole 1349: 1347: 1344: 1342: 1339: 1337: 1334: 1333: 1331: 1327: 1323: 1316: 1311: 1309: 1304: 1302: 1297: 1296: 1293: 1281: 1278: 1276: 1273: 1271: 1268: 1267: 1265: 1263: 1257: 1253: 1241: 1238: 1237: 1236: 1233: 1229: 1226: 1224: 1221: 1220: 1219: 1216: 1215: 1213: 1209: 1197: 1194: 1193: 1192: 1188: 1185: 1184: 1182: 1178: 1172: 1169: 1167: 1164: 1162: 1159: 1157: 1154: 1153: 1151: 1149: 1145: 1139: 1136: 1135: 1132: 1129: 1128: 1123: 1122:Cholera toxin 1120: 1118: 1115: 1114: 1113: 1110: 1109: 1104: 1101: 1099: 1096: 1095: 1094: 1091: 1090: 1088: 1086: 1082: 1079: 1077: 1073: 1070: 1068: 1062: 1058: 1048: 1045: 1043: 1040: 1038: 1035: 1033: 1030: 1028: 1025: 1023: 1020: 1018: 1015: 1014: 1011: 1008: 1006: 1003: 999: 996: 994: 991: 990: 989: 986: 985: 983: 981: 977: 971: 968: 966: 963: 961: 958: 956: 953: 951: 948: 946: 943: 941: 938: 936: 933: 931: 928: 926: 923: 921: 918: 916: 913: 911: 908: 907: 905: 903: 899: 893: 890: 888: 885: 883: 879: 876: 875: 872: 869: 867: 864: 862: 859: 857: 854: 852: 849: 847: 844: 842: 839: 837: 834: 832: 829: 827: 824: 823: 820: 817: 815: 812: 810: 807: 805: 802: 800: 797: 795: 792: 790: 787: 785: 782: 780: 777: 776: 773: 770: 768: 765: 763: 760: 759: 757: 755: 754:Glucuronosyl- 751: 744: 740: 737: 735: 732: 730: 727: 726: 724: 722: 718: 712: 709: 707: 704: 702: 699: 697: 694: 692: 689: 687: 684: 680: 677: 675: 672: 670: 667: 665: 662: 661: 660: 659:Phosphorylase 657: 656: 654: 652: 648: 645: 643: 637: 633: 628: 624: 620: 613: 608: 606: 601: 599: 594: 593: 590: 583: 579: 576: 575: 571: 562: 558: 553: 548: 544: 540: 539:J. Biol. Chem 536: 529: 526: 521: 517: 512: 507: 503: 499: 498:J. Biol. Chem 495: 488: 485: 480: 467: 456: 453: 448: 444: 439: 434: 430: 426: 422: 418: 414: 407: 404: 397: 395: 393: 389: 385: 381: 377: 373: 371: 367: 363: 359: 355: 351: 347: 343: 339: 335: 331: 327: 323: 319: 315: 313: 309: 305: 301: 297: 293: 289: 285: 283: 279: 275: 271: 267: 265: 261: 257: 253: 249: 245: 241: 237: 233: 229: 225: 221: 217: 213: 206: 204: 202: 199: 195: 192: 188: 185: 181: 178: 174: 169: 167: 164: 158: 156: 152: 148: 144: 141:is a type of 140: 134: 130: 118: 115: 113: 109: 106: 102: 98: 95: 93: 89: 85: 81: 78: 75: 71: 66: 62: 59: 56: 54: 50: 47: 44: 42: 38: 34: 30: 25: 20: 1694:EC 2.4 stubs 1684:Transferases 1639:expanding it 1625: 1617: 1565:Translocases 1562: 1549: 1536: 1523: 1510: 1500:Transferases 1497: 1484: 1341:Binding site 1262:transferases 1067:transferases 720: 642:transferases 619:Transferases 545:(1): 58–65. 542: 538: 528: 501: 497: 487: 466:cite journal 455: 420: 416: 406: 374: 316: 286: 268: 210: 170: 159: 138: 137: 35:Galactosyl_T 1336:Active site 721:Galactosyl- 27:Identifiers 1678:Categories 1539:Isomerases 1513:Hydrolases 1380:Regulation 674:Cellobiose 417:Biochem. J 398:References 173:CAZY GH_31 80:structures 1614:IPR002659 1418:EC number 1065:Pentosyl- 980:Mannosyl- 651:Glucosyl- 180:2.4.1.149 151:galactose 147:catalyzes 133:galactose 58:IPR002659 1689:EC 2.4.1 1610:InterPro 1442:Kinetics 1366:Cofactor 1329:Activity 902:Fucosyl- 669:Glycogen 640:Hexosyl- 282:B4GALNT4 278:B4GALNT3 274:B4GALNT2 270:B4GALNT1 216:B3GALNT2 212:B3GALNT1 201:2.4.1.79 97:RCSB PDB 53:InterPro 1598:Biology 1552:Ligases 1322:Enzymes 1280:ST8SIA4 1138:Sirtuin 871:UGT2B28 866:UGT2B17 861:UGT2B15 856:UGT2B11 851:UGT2B10 819:UGT1A10 743:C1GALT1 561:9417047 520:9417100 447:9334165 438:1218753 392:GALNTL6 388:GALNTL5 384:GALNTL4 380:GALNTL2 376:GALNTL1 370:GALNT14 366:GALNT13 362:GALNT12 358:GALNT11 354:GALNT10 312:B4GALT7 308:B4GALT6 304:B4GALT5 300:B4GALT4 296:B4GALT3 292:B4GALT2 288:B4GALT1 236:B3GALT6 232:B3GALT5 228:B3GALT4 224:B3GALT2 220:B3GALT1 166:2.4.1.- 46:PF01762 1631:enzyme 1628:EC 2.4 1584:Portal 1526:Lyases 1260:Sialyl 1256:2.4.99 1076:Ribose 915:POFUT2 910:POFUT1 846:UGT2B7 841:UGT2B4 836:UGT2A3 831:UGT2A2 826:UGT2A1 814:UGT1A9 809:UGT1A8 804:UGT1A7 799:UGT1A6 794:UGT1A5 789:UGT1A4 784:UGT1A3 779:UGT1A1 772:B3GAT3 767:B3GAT2 762:B3GAT1 664:Starch 584:(MeSH) 559:  518:  445:  435:  350:GALNT9 346:GALNT8 342:GALNT7 338:GALNT6 334:GALNT5 330:GALNT4 326:GALNT3 322:GALNT2 318:GALNT1 264:B3GNT8 260:B3GNT7 256:B3GNT6 252:B3GNT5 248:B3GNT4 244:B3GNT3 240:B3GNT2 145:which 112:PDBsum 86:  76:  32:Symbol 1626:This 1478:Types 1228:XYLT2 1223:XYLT1 1211:Other 1196:ECGF1 1180:Other 1061:2.4.2 1047:ALG12 998:POMT2 993:POMT1 970:FUT11 965:FUT10 636:2.4.1 242:; 194:2.4.1 187:2.4.1 1635:stub 1608:and 1606:Pfam 1570:list 1563:EC7 1557:list 1550:EC6 1544:list 1537:EC5 1531:list 1524:EC4 1518:list 1511:EC3 1505:list 1498:EC2 1492:list 1485:EC1 1042:ALG9 1037:ALG8 1032:ALG6 1027:ALG3 1022:ALG2 1017:ALG1 1010:DPM3 1005:DPM1 960:FUT9 955:FUT8 950:FUT7 945:FUT6 940:FUT5 935:FUT4 930:FUT3 925:FUT2 920:FUT1 892:HAS3 887:HAS2 882:HAS1 679:Myo- 629:2.4) 557:PMID 516:PMID 479:help 443:PMID 105:PDBj 101:PDBe 84:ECOD 74:Pfam 41:Pfam 547:doi 543:273 506:doi 502:273 433:PMC 425:doi 421:326 203:). 92:PDB 1680:: 1612:: 1258:: 1189:: 1063:: 880:: 638:: 627:EC 621:: 555:. 541:. 537:. 514:. 500:. 496:. 470:: 468:}} 464:{{ 441:. 431:. 419:. 415:. 394:; 390:; 386:; 382:; 378:; 372:; 368:; 364:; 360:; 356:; 352:; 348:; 344:; 340:; 336:; 332:; 328:; 324:; 320:; 314:; 310:; 306:; 302:; 298:; 294:; 290:; 284:; 280:; 276:; 272:; 266:; 262:; 258:; 254:; 250:; 246:; 238:; 234:; 230:; 226:; 222:; 218:; 214:; 198:EC 191:EC 184:EC 177:EC 163:EC 157:. 103:; 99:; 82:/ 1666:e 1659:t 1652:v 1641:. 1586:: 1572:) 1568:( 1559:) 1555:( 1546:) 1542:( 1533:) 1529:( 1520:) 1516:( 1507:) 1503:( 1494:) 1490:( 1314:e 1307:t 1300:v 745:) 741:( 625:( 611:e 604:t 597:v 563:. 549:: 522:. 508:: 481:) 477:( 449:. 427::

Index

Pfam
PF01762
InterPro
IPR002659
Pfam
structures
ECOD
PDB
RCSB PDB
PDBe
PDBj
PDBsum
structure summary

galactose
glycosyltransferase
catalyzes
galactose
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
EC
2.4.1.-
CAZY GH_31
EC
2.4.1.149
EC
2.4.1
EC
2.4.1
EC
2.4.1.79

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