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192:. In order to differentiate between the two, almost the entire structure needs to be removed and examined. While some pathologists classify keratoacanthoma as a distinct entity and not a malignancy, about 6% of clinical and histological keratoacanthomas do progress to invasive and aggressive squamous cell cancers; some pathologists may label KA as "well-differentiated squamous cell carcinoma, keratoacanthoma variant", and prompt definitive surgery may be recommended.
40:
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over the entire body. Treatments are not successful for many people with generalized eruptive keratoacanthoma. Use of emollients and anti-itch medications can ease some symptoms. Improvement or complete resolutions of the condition has occurred with the application of the following medications:
342:
Excision of the entire lesion, with adequate margin, will remove the lesion, allow full tissue diagnosis, and leave a planned surgical wound which can usually be repaired with a good cosmetic result. However, removing the entire lesion (especially on the face) may present difficult problems of
231:(also known as "Ferguson–Smith syndrome," "Ferguson-Smith type of multiple self-healing keratoacanthomas,") is a cutaneous condition, a variant of keratoacanthomas, which is characterized by the appearance of multiple, sometimes hundreds of keratoacanthomas.
351:
they are prepared to pay the extra costs of Mohs surgery.) Especially in more cosmetically-sensitive areas, and where the clinical diagnosis is reasonably certain, alternatives to surgery may include no treatment (awaiting spontaneous resolution).
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Frequently reported and reclassified over the last century, keratoacanthoma can be divided into various subtypes and despite being considered benign, their unpredictable behaviour has warranted the same attention as with squamous cell carcinoma.
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Keratoacanthomas presents as a fleshy, elevated and nodular lesion with an irregular crater shape and a characteristic central hyperkeratotic core. Usually the people will notice a rapidly growing dome-shaped tumor on sun-exposed skin.
333:
If the entire lesion is removed, the pathologist will probably be able to differentiate between keratoacanthoma and squamous cell carcinoma. Follow-up would be required to monitor for recurrence of disease.
244:(also known as "Generalized eruptive keratoacanthoma of Grzybowski") is a cutaneous condition, a variant of keratoacanthomas, characterized by hundreds to thousands of tiny follicular keratotic
394:
described a crateriform ulcer on the face”. In 1936, the same condition was renamed "molluscum sebaceum" by MacCormac and Scarf. Later, the term “keratoacanthoma” was coined by
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Recurrence after electrodesiccation and curettage can occur; it can usually be identified and treated promptly with either further curettage or surgical excision.
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scales and debris. It grows rapidly, reaching a large size within days or weeks, and if untreated for months will almost always starve itself of nourishment,
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The defining characteristic of a keratoacanthoma is that it is dome-shaped, symmetrical, surrounded by a smooth wall of inflamed skin, and capped with
177:(die), slough, and heal with scarring. Keratoacanthoma is commonly found on sun-exposed skin, often face, forearms and hands. It is rarely found at a
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608:
Weedon DD, et al. Squamous cell carcinoma arising in keratoacanthoma: a neglected phenomenon in the elderly. Am J Dermatopathol. 2010; 32(5):423–6
238:(also known as "Subungual keratoacanthoma") is a benign, but rapidly growing, locally aggressive tumor which sometimes occur in the nail apparatus.
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158:) is a common low-grade (unlikely to metastasize or invade) rapidly-growing skin tumour that is believed to originate from the hair follicle (
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may allow for good margin control with minimal tissue removal, but many insurance companies require the definitive diagnosis of a malignancy
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Keratoacanthoma may be difficult to distinguish visually from a skin cancer. Under the microscope, keratoacanthoma very closely resembles
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Kossard S; Tan KB; Choy C; Keratoacanthoma and infundibulocystic squamous cell carcinoma. Am J Dermatopathol. 2008; 30(2):127–34 (
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Niebuhr M, et al. Giant keratoacanthoma in an immunocompetent patient with detection of HPV 11. Hautarzt. 2009; 60(3):229–32 (
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is a cutaneous condition, a variant of keratoacanthomas, which is characterized by multiple tumors growing in a localized area.
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Cerroni, Lorenzo; Kerl, Helmut (2012), Goldsmith, Lowell A.; Katz, Stephen I.; Gilchrest, Barbara A.; Paller, Amy S. (eds.),
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Keratoacanthomas usually occurs in older individuals. A number of causes have been suggested including
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Many new treatments for melanoma are also known to increase the rate of keratoacanthoma, such as the
724:"Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy"
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often suffice to control keratoacanthomas until they regress. Other modalities of treatment include
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ROOK, ARTHUR; WHIMSTER, IAN (January 1979). "Keratoacanthoma–a thirty year retrospect".
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294:. As with squamous cell cancer, sporadic cases have been found co-infected with the
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Ko CJ, Keratoacanthoma: facts and controversies. Clin
Dermatol. 2010; 28(3):254–61 (
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are a variant of keratoacanthoma, which may reach dimensions of several centimeters.
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Baran, Robert; Berker, David A. R. de; Holzberg, Mark; Thomas, Luc (2012).
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298:(HPV). Although HPV has been suggested as a causal factor, it is unproven.
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513:
Schwartz RA. The
Keratoacanthoma: A Review. J Surg Oncol 1979; 12:305–17.
174:
105:
681:"Grzybowski generalized eruptive keratoacanthomas | DermNet New Zealand"
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998:
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245:
893:
HJORTH, NIELS (August 1960). "Keratoacanthoma: A Historical Note".
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485:
Joseph A. Regezi; James
Sciubba; Richard C. K. Jordan (2012).
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Baran and Dawber's
Diseases of the Nails and their Management
212:
Keratoacanthomas may be divided into the following types:
491:
Oral
Pathology - E-Book: Clinical Pathologic Correlations
572:"Keratoacanthoma: Background, Pathophysiology, Etiology"
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James, William; Berger, Timothy; Elston, Dirk (2005).
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A person with generalized eruptive keratoacanthomas
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Multiple keratoacanthomas (Ferguson–Smith syndrome)
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85:Generalized eruptive keratoacanthoma of Grzybowski
18:Generalized eruptive keratoacanthoma of Grzybowski
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343:plastic reconstruction. (On the nose and face,
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1563:Inflammatory linear verrucous epidermal nevus
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827:Fitzpatrick's Dermatology in General Medicine
630:Fitzpatrick's Dermatology in General Medicine
8:
440:
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1319:Aggressive digital papillary adenocarcinoma
852:Journal of the American Medical Association
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1355:Primary cutaneous adenoid cystic carcinoma
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779:http://www.medscape.com/viewarticle/467069
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445:Zito, Patrick M.; Scharf, Richard (2018),
325:Microscopic view of a skin keratoacanthoma
38:
29:
749:
739:
1573:Pigmented hairy epidermal nevus syndrome
777:Keratoacanthoma. Désirée Ratner. 2004.
1612:Unilateral palmoplantar verrucous nevus
829:(8 ed.), The McGraw-Hill Companies
527:"Keratoacanthoma | DermNet New Zealand"
432:
1617:Zosteriform speckled lentiginous nevus
1464:Keratoacanthoma centrifugum marginatum
223:Keratoacanthoma centrifugum marginatum
82:Keratoacanthoma centrifugum marginatum
7:
1658:Epidermal nevi, neoplasms, and cysts
1233:Nevoid basal-cell carcinoma syndrome
566:
564:
242:Generalized eruptive keratoacanthoma
398:and the term became established by
950:10.1111/j.1365-2133.1979.tb03568.x
907:10.1111/j.1365-2133.1960.tb13896.x
493:. Elsevier Saunders. p. 155.
25:
1568:Linear verrucous epidermal nevus
864:10.1001/jama.1954.03690240028008
1583:Phakomatosis pigmentokeratotica
938:British Journal of Dermatology
895:British Journal of Dermatology
823:"Chapter 117. Keratoacanthoma"
355:On the trunk, arms, and legs,
1:
1345:Microcystic adnexal carcinoma
846:Levy, Edwin J. (1954-06-05).
371:; intralesional injection of
286:, recent injury to the skin,
1578:Systematized epidermal nevus
1324:Extramammary Paget's disease
416:List of cutaneous conditions
1674:
1551:Nevus comedonicus syndrome
1186:Fibroepithelioma of Pinkus
632:. (6th ed.). McGraw-Hill.
628:Freedberg, et al. (2003).
1018:D23.L71) (ICD10.v4 L85.8)
797:. John Wiley & Sons.
453:, StatPearls Publishing,
229:Multiple keratoacanthomas
128:Squamous cell skin cancer
76:Subungual keratoacanthoma
46:
37:
1546:Schimmelpenning syndrome
1541:Epidermal nevus syndrome
1296:Erythroplasia of Queyrat
662:. (10th ed.). Saunders.
236:solitary keratoacanthoma
581:(subscription required)
190:squamous cell carcinoma
164:squamous cell carcinoma
1426:Pilar sheath acanthoma
326:
305:inhibitor medications
292:genetic predisposition
217:Giant keratoacanthomas
205:
179:mucocutaneous junction
123:Differential diagnosis
73:Giant keratoacanthomas
1365:Malignant mixed tumor
1340:Merkel-cell carcinoma
781:accessed 23 June 2015
379:have also been used.
324:
296:human papilloma virus
203:
98:Ultraviolet radiation
1459:Generalized eruptive
1436:Seborrheic keratosis
722:Niezgoda, A (2015).
1602:Nevus unius lateris
1360:Verrucous carcinoma
741:10.1155/2015/851387
392:Jonathan Hutchinson
162:) and can resemble
1350:Mucinous carcinoma
1291:Bowenoid papulosis
1064:External resources
396:Walter Freudenthal
357:electrodesiccation
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160:pilosebaceous unit
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1441:Warty dyskeratoma
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1301:Actinic keratosis
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848:"Keratoacanthoma"
685:www.dermnetnz.org
578:. 14 August 2018.
531:www.dermnetnz.org
500:978-1-4557-0262-6
447:"Keratoacanthoma"
421:Marian Grzybowski
288:immunosuppression
280:ultraviolet light
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113:Diagnostic method
102:immunosuppression
27:Medical condition
16:(Redirected from
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1492:Verruca vulgaris
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1269:Signet-ring-cell
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176:
172:
167:
165:
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157:
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144:
140:
136:
132:
129:
126:
124:
120:
117:Tissue biopsy
116:
114:
110:
107:
103:
99:
96:
94:
90:
84:
81:
78:
75:
72:
71:
70:
66:
63:
59:
56:
54:
50:
45:
41:
36:
31:
19:
1502:Plantar wart
1450:
1274:Spindle-cell
1221:Rodent ulcer
1196:Micronodular
1191:Infiltrative
1082:
1071:
1047:
1036:
1021:
1005:
944:(1): 41–47.
941:
937:
931:
898:
894:
888:
858:(6): 562–4.
855:
851:
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831:, retrieved
826:
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727:
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690:17 September
688:. Retrieved
684:
675:
659:
629:
604:
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546:
536:17 September
534:. Retrieved
530:
509:
490:
464:17 September
462:, retrieved
450:
404:Ian Whimster
389:
381:
373:methotrexate
369:radiotherapy
354:
348:
345:Mohs surgery
341:
332:
328:
300:
277:
263:methotrexate
259:fluorouracil
255:isotretinoin
241:
235:
228:
222:
216:
211:
207:
187:
168:
155:
151:
150:
143:Mohs surgery
93:Risk factors
1226:Superficial
1176:Cicatricial
1132:Skin cancer
400:Arthur Rook
365:cryosurgery
307:vemurafenib
284:carcinogens
282:, chemical
58:Dermatology
1537:Syndromes
1409:Clear-cell
1399:Large-cell
1264:Clear-cell
1084:Patient UK
1049:DiseasesDB
833:2018-08-20
734:: 851387.
451:StatPearls
427:References
311:dabrafenib
1626:Ungrouped
1404:Fissuring
1388:Acanthoma
1333:Ungrouped
1216:Pore-like
1206:Pigmented
1151:Carcinoma
1136:epidermis
1073:eMedicine
958:0007-0963
915:0007-0963
872:0002-9955
710:1432-1173
597:1533-0311
556:1879-1131
406:in 1950.
361:curettage
338:Treatment
317:Diagnosis
251:acitretin
137:Surgery (
134:Treatment
53:Specialty
1652:Category
1474:Solitary
1469:Multiple
1259:Basaloid
1211:Polypoid
1171:Aberrant
1078:derm/206
974:27373097
923:71452344
880:13162754
760:26171394
576:Medscape
459:29763106
410:See also
139:excision
106:genetics
1254:Adenoid
1201:Nodular
1134:of the
1043:D007636
1014:: D23 (
751:4478296
386:History
246:papules
175:necrose
171:keratin
1592:Other
1395:Forms
1380:tumors
1378:Benign
1250:Forms
1181:Cystic
1167:Forms
972:
966:427012
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349:before
181:or on
1594:nevus
1524:Other
1143:Tumor
1054:29383
1032:238.2
970:S2CID
919:S2CID
274:Cause
68:Types
1484:Wart
1038:MeSH
1027:9-CM
1016:ILDS
962:PMID
954:ISSN
911:ISSN
876:PMID
868:ISSN
799:ISBN
756:PMID
732:2015
706:ISSN
692:2018
664:ISBN
634:ISBN
593:ISSN
552:ISSN
538:2018
495:ISBN
466:2018
455:PMID
367:and
359:and
309:and
303:BRAF
290:and
1243:SCC
1160:BCC
1023:ICD
1007:ICD
946:doi
942:100
903:doi
860:doi
856:155
746:PMC
736:doi
375:or
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