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Germ theory of disease

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456:(or "Kirchner", as it is often spelled) may have observed such microorganisms prior to this. One of his books written in 1646 contains a chapter in Latin, which reads in translation: "Concerning the wonderful structure of things in nature, investigated by microscope...who would believe that vinegar and milk abound with an innumerable multitude of worms." Kircher defined the invisible organisms found in decaying bodies, meat, milk, and secretions as "worms." His studies with the microscope led him to the belief, which he was possibly the first to hold, that disease and putrefaction, or decay were caused by the presence of invisible living bodies, writing that "a number of things might be discovered in the blood of fever patients." When Rome was struck by the bubonic plague in 1656, Kircher investigated the blood of plague victims under the microscope. He noted the presence of "little worms" or "animalcules" in the blood and concluded that the disease was caused by microorganisms. 190:: "pollution"), a noxious form of "bad air" emanating from rotting organic matter. Miasma was considered to be a poisonous vapor or mist filled with particles from decomposed matter (miasmata) that was identifiable by its foul smell. The theory posited that diseases were the product of environmental factors such as contaminated water, foul air, and poor hygienic conditions. Such infections, according to the theory, were not passed between individuals but would affect those within a locale that gave rise to such vapors. 449:, considered "the Father of Microbiology". Leeuwenhoek is said to be the first to see and describe bacteria in 1674, yeast cells, the teeming life in a drop of water (such as algae), and the circulation of blood corpuscles in capillaries. The word "bacteria" didn't exist yet, so he called these microscopic living organisms "animalcules", meaning "little animals". Those "very little animalcules" he was able to isolate from different sources, such as rainwater, pond and well water, and the human mouth and intestine. 465:, published in Rome in 1658. Kircher's conclusion that disease was caused by microorganisms was correct, although it is likely that what he saw under the microscope were in fact red or white blood cells and not the plague agent itself. Kircher also proposed hygienic measures to prevent the spread of disease, such as isolation, quarantine, burning clothes worn by the infected, and wearing facemasks to prevent the inhalation of germs. It was Kircher who first proposed that living beings enter and exist in the blood. 96:. Even when a pathogen is the principal cause of a disease, environmental and hereditary factors often influence the severity of the disease, and whether a potential host individual becomes infected when exposed to the pathogen. Pathogens are disease-carrying agents that can pass from one individual to another, both in humans and animals. Infectious diseases are caused by biological agents such as pathogenic microorganisms (viruses, bacteria, and fungi) as well as parasites. 718: 3813: 2667: 22: 882: 3837: 3825: 438:, the theory that living creatures arise from nonliving matter. He observed that maggots only arose from rotting meat that was uncovered. When meat was left in jars covered by gauze, the maggots would instead appear on the gauze's surface, later understood as rotting meat's smell passing through the mesh to attract flies that laid eggs. 142: 405:
appears to have had some idea of the contagion theory, commenting, "I have survived three plagues and visited several people who had two plague spots which I touched. But it did not hurt me, thank God. Afterwards when I returned home, I took up Margaret," (born 1534), "who was then a baby, and put my
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From pp. 131–32: " … there was the awful spectacle of men dying like sheep, through having caught the infection in nursing each other. This caused the greatest mortality. On the one hand, if they were afraid to visit each other, they perished from neglect; indeed many houses were emptied of their
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From p. 292: "This new malady and pest, therefore, either suddenly falls into the water, or penetrates into the very corn, or into other food of men and cattle. Or even, as may be the case, the infection remains suspended in the air itself; and when, as we breathe, we inhale the air mingled with
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of cholera violating the first postulate. For this same reason, the third postulate specifies "should", rather than "must", because not all host organisms exposed to an infectious agent will acquire the infection, potentially due to differences in prior exposure to the pathogen.Limiting the second
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and that matter from autopsies was implicated in its spread, Semmelweis made doctors wash their hands with chlorinated lime water before examining pregnant women. He then documented a sudden reduction in the mortality rate from 18% to 2.2% over a period of a year. Despite this evidence, he and his
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disease known as "muscardine" in French and "calcinaccio" or "mal del segno" in Italian, causing white fungal spots along the caterpillar. From 1835 to 1836, Bassi published his findings that fungal spores transmitted the disease between individuals. In recommending the rapid removal of diseased
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in the soil and the air were responsible for causing specific diseases. Von Plenciz noted the distinction between diseases which are both epidemic and contagious (like measles and dysentery), and diseases which are contagious but not epidemic (like rabies and leprosy). The book cites Anton van
286:(Three Books on Agriculture, 36 BC): "Precautions must also be taken in the neighborhood of swamps... because there are bred certain minute creatures which cannot be seen by the eyes, which float in the air and enter the body through the mouth and nose and there cause serious diseases." 418:), a set of three books covering the nature of contagious diseases, categorization of major pathogens, and theories on preventing and treating these conditions. Fracastoro blamed "seeds of disease" that propagate through direct contact with an infected host, indirect contact with 159:
The miasma theory was the predominant theory of disease transmission before the germ theory took hold towards the end of the 19th century; it is no longer accepted as a correct explanation for disease by the scientific community. It held that diseases such as
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or "germs" can cause disease. These small organisms, which are too small to be seen without magnification, invade humans, other animals, and other living hosts. Their growth and reproduction within their hosts can cause disease. "Germ" refers to not just a
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in Paris. By 1853, he was convinced that malaria and yellow fever were spread by mosquitos. He even identified the particular group of mosquitos that transmit yellow fever as the "domestic species" of "striped-legged mosquito", which can be recognised as
329:), Galen explained that patients might relapse during recovery from fever because some "seed of the disease" lurked in their bodies, which would cause a recurrence of the disease if the patients did not follow a physician's therapeutic regimen. 3623: 827:
postulate, it was later discovered that viruses cannot be grown in pure cultures because they are obligate intracellular parasites, making it impossible to fulfill the second postulate. Similarly, pathogenic misfolded proteins, known as
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were relatively safe. Investigating further, Semmelweis made the connection between puerperal fever and examinations of delivering women by doctors, and further realized that these physicians had usually come directly from
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Leeuwenhoek to show how ubiquitous such animalcules are and was unique for describing the presence of germs in ulcerating wounds. Ultimately, the theory espoused by von Plenciz was not accepted by the scientific community.
563:, the actual vector. He published his theory in 1854 in the Gaceta Oficial de Cumana ("Official Gazette of Cumana"). His reports were assessed by an official commission, which discarded his mosquito theory. 675:
In the book's second edition, published in 1855, Snow theorized that cholera was caused by cells smaller than human epithelial cells, leading to Robert Koch's 1884 confirmation of the bacterial species
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From p. 90 of "The invisible world revealed by the microscope or, thoughts on animalcules.", second edition, 1850 (May have appeared in first edition, too. (Revise date in article to 1846, if so.))
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in the 1880s. By the end of that decade, the miasma theory was struggling to compete with the germ theory of disease. Viruses were initially discovered in the 1890s. Eventually, a "golden era" of
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when in direct contact with the external environment's air by removing the curved tubing, Pasteur demonstrated that bacteria must travel between sites of infection to colonize environments.
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was commonplace in Europe, though doctors were unaware of how it worked or how to extend the principle to other diseases. A transitional period began in the late 1850s with the work of
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experiment illustrates that liquid nutrients are spoiled by particles in the air rather than the air itself. These results of these experiments supported the germ theory of disease.
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for his early 18th century writings that claimed swamp miasma spread malaria, rebutting that bad air from decomposing organisms was not present in all cases. In his 1849 pamphlet
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Singer, Charles and Dorothea (1917) "The scientific position of Girolamo Fracastoro with especial reference to the source, character and influence of his theory of infection,"
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Santer M (2009). "Richard Bradley: a unified, living agent theory of the cause of infectious diseases of plants, animals, and humans in the first decades of the 18th century".
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The microorganism must be re-isolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent.
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theorised that the plague and "all pestilential distempers" were caused by "poisonous insects", living creatures viewable only with the help of microscopes.
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Tsoucalas G, Spengos K, Panayiotakopoulos G, Papaioannou T, Karamanou M (15 February 2018). "Epilepsy, Theories and Treatment Inside Corpus Hippocraticum".
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pioneered using microscopy in relation to diseases and independently developed a theory that all infectious diseases were due to parasitic infection with "
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unwashed hands on her face, because I had forgotten; otherwise I should not have done it, which would have been tempting God." In 1546, Italian physician
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Kircher was the first to attribute infectious disease to a microscopic pathogen, inventing the germ theory of disease, which he outlined in his
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to remove the handles of contaminated pumps, he noted that the outbreak's cases were already declining as scared residents fled the region.
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as the causative agent. In recognizing a biological origin, Snow recommended boiling and filtering water, setting the precedent for modern
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The microorganism must be found in abundance in all organisms with the disease, but should not be found in healthy organisms.
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Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
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in 1857, Pasteur applied the findings to recommend improved ventilation and screening of silkworm eggs, an early form of
275:) stated that the world contained various "seeds", some of which could sicken a person if they were inhaled or ingested. 133:
ensued, during which the germ theory quickly led to the identification of the actual organisms that cause many diseases.
3868: 3346: 3073: 2491: 2471: 1893: 146: 25: 2305: 3493: 3386: 3297: 3110: 3098: 3007: 2696: 2670: 2367: 2270: 1439: 484: 318:), Galen speculated that plagues were spread by "certain seeds of plague", which were present in the air. And in his 232:
One theory of the spread of contagious diseases that were not spread by direct contact was that they were spread by
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During the early 19th century, driven by economic concerns over collapsing silk production, Italian entomologist
2247: 3829: 3523: 3222: 2934: 2830: 2426: 2026: 697:, Snow showed that areas supplied by this company experienced fourteen times as many deaths as residents using 547: 338: 3794: 3721: 3553: 2544: 2481: 2421: 1092: 1026: 985: 582: 3292: 3817: 3568: 2778: 2689: 2574: 2496: 2456: 1193: 722: 669: 657: 435: 279: 1461: 3873: 3774: 3558: 3093: 2994: 2887: 2736: 2595: 1375:"Flies from meat and wasps from trees: Reevaluating Francesco Redi's spontaneous generation experiments" 910: 742: 525: 442: 346: 3137: 665: 1374: 1115: 3749: 3533: 3398: 3364: 3312: 3132: 3078: 3034: 2924: 2862: 2751: 2746: 2627: 2600: 2539: 2486: 823: 798: 778: 118: 1142:"The seeds of disease: an explanation of contagion and infection from the Greeks to the Renaissance" 3759: 3754: 3528: 3327: 3317: 3152: 2761: 2632: 2569: 2461: 2446: 1282: 683: 407: 165: 100: 993: 822:
During his lifetime, Koch recognized that the postulates were not universally applicable, such as
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inmates for want of a nurse: on the other, if they ventured to do so, death was the consequence."
603: 534: 453: 358: 104: 93: 350:(1025). He mentioned that people can transmit disease to others by breath, noted contagion with 831:, only spread by transmitting their structure to other proteins, rather than self-replicating. 689:
Through a statistical analysis tying cholera cases to specific water pumps associated with the
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In the 18th century, more proposals were made, but struggled to catch on. In 1700, physician
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Susser, Mervyn; Stein, Zena (August 2009). "10: Germ Theory, Infection, and Bacteriology".
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Del Mal del Segno, Calcinaccio o Moscardino : Malattia che Affligge i Bachi da Seta
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The cultured microorganism should cause disease when introduced into a healthy organism.
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caterpillars and disinfection of their surfaces, Bassi outlined methods used in modern
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of the cholera epidemic depicts the spread of the disease in the form of poisonous air.
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following births assisted by doctors and medical students. However, those attended by
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Building on Redi's work, Pasteur disproved spontaneous generation by constructing
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The microorganism must be isolated from a diseased organism and grown in pure
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Microorganisms are said to have been first directly observed in the 1670s by
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Similar to Bassi, Pasteur extended his research on germ theory by studying
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After reading Pasteur's papers on bacterial fermentation, British surgeon
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of Koch's postulates to establish correlation between microbial genes and
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While Koch's postulates retain historical importance for emphasizing that
3369: 3122: 2756: 2726: 2612: 2103: 1237: 594: 473: 394:–1370) of Bologna, Italy mentioned Galen's "seeds of plague" in his work 341: 73: 64: 1847:"Extension Of The Germ Theory To The Etiology Of Certain Common Disease" 532:
named the causative fungal species after Bassi, currently classified as
141: 3041: 2283: 2014: 1999:"Über den augenblicklichen Stand der bakteriologischen Choleradiagnose" 1496: 767:, a disease that causes brown spots on silkworms. While Swiss botanist 575: 161: 89: 56: 40: 1219:. Vol. Book 1. London, England: G. Bell and Sons, Ltd. p. 9. 1114:(London, England: J.M. Dent & Sons, Ltd., 1910), Book III, § 51, 705:. While Snow received praise for convincing the Board of Guardians of 3336: 1815: 867: 419: 244:) that were present in and dispersible through the air. In his poem, 173: 85: 1998: 354:, and discussed the transmission of disease through water and dirt. 870:
could be applied to the site of injury as an effective antiseptic.
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in 1762. However, such views were held in disdain in Europe, where
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argued that microorganisms he called "worms" were responsible for
237: 233: 140: 108: 81: 77: 20: 589:) in 1847, noticed the dramatically high maternal mortality from 3430: 2681: 2209:"Molecular Koch's postulates applied to microbial pathogenicity" 1559:
Bad Sign, Rubble, or Muscardine: Disease that Afflicts Silkworms
1336: 229:, that diseases could spread from an infected person to others. 2685: 2363: 1678:"Ignaz Semmelweis, Carl Mayrhofer, and the rise of germ theory" 1528:
Conquest of Epidemic Disease: A Chapter in the History of Ideas
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containing nutrient broth. Since the flask contents were only
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A hybrid form of miasma and contagion theory was proposed by
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Committee on the Environment, Public Health and Food Safety
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between specific microorganisms and diseases, now known as
951:"Definition of Germ in English from the Oxford dictionary" 491:. It outlined a theory of contagion stating that specific 2055:. Washington DC: American Society of Microbiology Press. 307:) that some patients might have "seeds of fever". In his 626:, spent time with his microscope, and speculated in his 1637:"The inside history of a great medical discovery. 1915" 225:) was the first person to write, in his account of the 80:, or other pathogens that can cause disease, such as 1265:. New Canaan, CT: Keats Publishing Inc. p. 212. 701:
pumps that obtained water from the upriver, cleaner
3742: 3701: 3588: 3577: 3514: 3439: 3355: 3283: 3188: 2993: 2719: 2583: 2515: 2402: 2264:Pitt, Dennis; Aubin, Jean-Michel (1 October 2012). 729:During the mid-19th century, French microbiologist 611:by most of the contemporary medical establishment. 1984:Mittheilungen aus dem Kaiserlichen Gesundheitsamte 1018: 2003:Zeitschrift für Hygiene und Infektionskrankheiten 1982:Koch R (1884). "Die Aetiologie der Tuberkulose". 1312:Esperienze Intorno alla Generazione degl' Insetti 2053:Robert Koch: a life in medicine and bacteriology 693:, which supplied sewage-polluted water from the 622:, the Sussex doctor more famous for discovering 114:remained dominant among scientists and doctors. 1433:"The Life and Work of Athanaseus Kircher, S.J." 546:In 1838 French specialist in tropical medicine 664:Snow proposed that cholera spread through the 398:(Helpful commentaries on the books of Galen). 2697: 2623:History of the creation-evolution controversy 2375: 2164:Clinical and Diagnostic Laboratory Immunology 2158:Jacomo V, Kelly PJ, Raoult D (January 2002). 1135: 1133: 1131: 1129: 1127: 1125: 396:Commentaria non-parum utilia in libros Galeni 8: 1188:Lucretius with Rev. John S. Watson, trans., 982:Eras in Epidemiology: The Evolution of Ideas 99:Basic forms of germ theory were proposed by 1927:"Koch's postulates and infectious proteins" 1263:Table Talk Conversations with Martin Luther 3659:Centers for Disease Control and Prevention 3585: 2704: 2690: 2682: 2382: 2368: 2360: 1925:Walker L, Levine H, Jucker M (July 2006). 434:published experimental evidence rejecting 92:. Diseases caused by pathogens are called 72:but to any type of microorganism, such as 3619:Centre for Disease Prevention and Control 3609:Center for Disease Control and Prevention 2653:Relationship between religion and science 2291: 2266:"Joseph Lister: Father of Modern Surgery" 2183: 2134: 2093: 1950: 1852:Comptes rendus de l'Académie des Sciences 1771: 1701: 1652: 1165: 1110:Thucydides with Richard Crawley, trans., 994:10.1093/acprof:oso/9780195300666.003.0010 793:published four criteria for establishing 691:Southwark and Vauxhall Waterworks Company 2334:Supplemental Lecture (98/03/28 update), 2082:The Yale Journal of Biology and Medicine 1317:Experiments on the Generation of Insects 662:On the Mode of Communication of Cholera, 656:. Snow criticized the Italian anatomist 368:–636) mentioned "plague-bearing seeds" ( 3664:Health departments in the United States 1811:On the Mode of Communication of Cholera 942: 916:History of emerging infectious diseases 602:. Asserting that puerperal fever was a 3669:Council on Education for Public Health 1017:Last JM, ed. (2007), "miasma theory", 506:Germ theory's key 19th century figures 3727:Professional degrees of public health 3634:Ministry of Health and Family Welfare 1888: 1886: 1803: 1801: 1799: 1597: 1595: 1197:it, we must necessarily absorb those 1025:, Westminster College, Pennsylvania: 452:Yet German Jesuit priest and scholar 7: 3824: 3717:Bachelor of Science in Public Health 2351:Science's war on infectious diseases 2308:from the original on 22 January 2023 1906:from the original on 4 February 2023 1867:from the original on 22 January 2023 1616:from the original on 19 January 2023 1485:Perspectives in Biology and Medicine 1290:from the original on 18 January 2023 836:correlation does not imply causation 487:(1705–1786) published a book titled 416:On Contagion and Contagious Diseases 289:The Greek physician Galen (AD 129 – 3836: 2985:Workers' right to access the toilet 2826:Human right to water and sanitation 648:is credited as a founder of modern 422:, or through particles in the air. 412:De Contagione et Contagiosis Morbis 2530:Central dogma of molecular biology 2029:from the original on 28 April 2023 1442:from the original on 17 April 2016 1413:from the original on 14 April 2019 741:killed the microorganisms causing 654:1854 Broad Street cholera outbreak 640:1854 Broad Street cholera outbreak 125:. This work was later extended by 14: 3258:Commercial determinants of health 1826:from the original on 6 March 2023 1609:American Society for Microbiology 1602:Lovett, Brian (6 December 2019). 1436:The Museum of Jurassic Technology 1063:10.2174/1381612823666171024153144 530:Giuseppe Gabriel Balsamo-Crivelli 344:(known as Avicenna in Europe) in 3835: 3823: 3812: 3811: 2841:National public health institute 2666: 2665: 2228:10.1093/cid/10.Supplement_2.S274 1580:from the original on 1 July 2023 1462:"The History of the Germ Theory" 1373:Parke, Emily C. (1 March 2014). 1354:from the original on 1 July 2023 1276:Morgan, Ewan (22 January 2021). 1112:History of the Peloponnesian War 880: 542:Louis-Daniel Beauperthuy, France 483:In 1762, the Austrian physician 16:Prevailing theory about diseases 3238:Open-source healthcare software 2980:Sociology of health and illness 2123:Journal of Medical Microbiology 1734:Snowise, Neil G. (7 May 2021). 1233:Encyclopedia of the Black Death 1211:Varro MT, Storr-Best L (1912). 789:In 1884, German bacteriologist 309:On the Different Types of Fever 3599:Caribbean Public Health Agency 3411:Sexually transmitted infection 3308:Statistical hypothesis testing 3069:Occupational safety and health 2970:Sexual and reproductive health 2883:Occupational safety and health 2555:One gene–one enzyme hypothesis 2216:Reviews of Infectious Diseases 1472:(1415): 312. 11 February 1888. 1261:Smith, Preserved, ed. (1979). 771:discovered the fungal species 357:During the early Middle Ages, 103:in 1546, and expanded upon by 1: 3253:Social determinants of health 1986:. Vol. 2. pp. 1–88. 1845:Pasteur, Louis (3 May 1880). 1654:10.1093/milmed/166.suppl_1.68 1051:Current Pharmaceutical Design 1021:A Dictionary of Public Health 476:and other diseases. In 1720, 388: 377: 362: 323: 312: 301: 290: 269: 262: 251: 219: 212: 3313:Analysis of variance (ANOVA) 3074:Human factors and ergonomics 2336:www.mansfield.ohio-state.edu 1894:"The Middle Years 1862–1877" 1859:. Translated by H.C. Ernst. 1740:Journal of Medical Biography 1530:. Hafner Publishing Co Ltd. 174: 26:Scanning electron microscope 3494:Good manufacturing practice 3298:Randomized controlled trial 2271:Canadian Journal of Surgery 2117:Inglis TJ (November 2007). 1466:The British Medical Journal 1391:10.1016/j.shpsc.2013.12.005 485:Marcus Antonius von Plenciz 430:In 1668, Italian physician 117:By the early 19th century, 3892: 3564:Theory of planned behavior 3489:Good agricultural practice 3394:Public health surveillance 3286:epidemiological statistics 2930:Public health intervention 2355:www.creatingtechnology.org 2176:10.1128/CDLI.9.1.8-18.2002 1879:Modern History Sourcebook. 1861:French Academy of Sciences 1676:Carter KC (January 1985). 699:Lambeth Waterworks Company 637: 556:French Academy of Sciences 503: 462:Scrutinium Physico-Medicum 401:The 16th century Reformer 284:Rerum rusticarum libri III 282:(116–27 BC) wrote, in his 250:(On the Nature of Things, 194:Development of germ theory 182: 152: 51:is the currently accepted 3807: 3686:World Toilet Organization 3681:World Health Organization 3248:Public health informatics 2955:Right to rest and leisure 2784:Globalization and disease 2661: 1943:10.1007/s00401-006-0072-x 1756:10.1177/09677720211013807 1694:10.1017/S0025727300043738 1158:10.1017/s0025727300042241 1140:Nutton V (January 1983). 1085:Annals of Medical History 745:while avoiding damage to 733:showed that treating the 567:Ignaz Semmelweis, Austria 3732:Schools of public health 3524:Diffusion of innovations 3223:Health impact assessment 2935:Public health laboratory 2831:Management of depression 2342:The Germ Theory Timeline 1571:10.5962/bhl.title.152962 1551:Bassi, Agostino (1836). 1329:10.5962/bhl.title.149072 1309:Redi, Francesco (1668). 548:Louis-Daniel Beauperthuy 3795:Social hygiene movement 3722:Doctor of Public Health 3554:Social cognitive theory 3356:Infectious and epidemic 3138:Fecal–oral transmission 2346:germtheorytimeline.info 1190:On the Nature of Things 1027:Oxford University Press 986:Oxford University Press 668:, replicating in human 628:Thoughts on Animalcules 587:Allgemeines Krankenhaus 583:Vienna General Hospital 526:preventative healthcare 500:19th and 20th centuries 426:The Early Modern Period 374:On the Nature of Things 3790:Germ theory of disease 3569:Transtheoretical model 2575:Spontaneous generation 2525:Germ theory of disease 2502:Zoology (through 1859) 2332:Germ Theory of Disease 2222:(Suppl 2): S274–S276. 1194:see especially p. 292. 726: 723:spontaneous generation 658:Giovanni Maria Lancisi 445:, an early pioneer in 436:spontaneous generation 280:Marcus Terentius Varro 207:, the Greek historian 150: 49:germ theory of disease 44: 3674:Public Health Service 3559:Social norms approach 3549:PRECEDE–PROCEED model 2995:Preventive healthcare 2888:Pharmaceutical policy 2737:Chief Medical Officer 2596:Philosophy of biology 2136:10.1099/jmm.0.47179-0 2076:Evans AS (May 1976). 1931:Acta Neuropathologica 1635:Agramonte, A (2001). 911:Germ theory denialism 824:asymptomatic carriers 743:postpartum infections 720: 713:Louis Pasteur, France 528:. Italian naturalist 511:Agostino Bassi, Italy 443:Anton van Leeuwenhoek 347:The Canon of Medicine 144: 24: 3750:Sara Josephine Baker 3649:Public Health Agency 3534:Health communication 3399:Disease surveillance 3365:Asymptomatic carrier 3347:Statistical software 3035:Preventive nutrition 2863:Medical anthropology 2752:Environmental health 2628:Human Genome Project 2540:Great chain of being 2507:Zoology (since 1859) 2442:Evolutionary thought 2412:Agricultural science 2340:William C. Campbell 2129:(Pt 11): 1419–1422. 1902:. 10 November 2016. 1561:] (in Italian). 1319:] (in Italian). 1098:16 June 2020 at the 988:. pp. 107–122. 785:Robert Koch, Germany 779:disease surveillance 735:female genital tract 489:Opera medico-physica 296:) speculated in his 278:The Roman statesman 145:A representation by 119:smallpox vaccination 3869:Infectious diseases 3760:Carl Rogers Darnall 3755:Samuel Jay Crumbine 3529:Health belief model 3382:Notifiable diseases 3318:Regression analysis 3153:Waterborne diseases 2742:Cultural competence 2633:Humboldtian science 2570:Sequence hypothesis 2477:Molecular evolution 1808:Snow, John (1855). 1526:Winslow CE (1967). 1283:Scientific American 955:Oxford Dictionaries 684:boil-water advisory 408:Girolamo Fracastoro 166:chlamydia infection 101:Girolamo Fracastoro 94:infectious diseases 3358:disease prevention 3293:Case–control study 2965:Security of person 2814:Health care reform 2643:Natural philosophy 2591:History of science 2391:History of biology 2330:Stephen T. Abedon 2284:10.1503/cjs.007112 2015:10.1007/BF02284324 1877:Fordham University 1647:(9 Suppl): 68–78. 1497:10.1353/pbm.0.0124 864:compound fractures 727: 644:British physician 615:Gideon Mantell, UK 604:contagious disease 535:Beauveria bassiana 454:Athanasius Kircher 383:). Later in 1345, 359:Isidore of Seville 257:), the Roman poet 151: 105:Marcus von Plenciz 45: 3851: 3850: 3803: 3802: 3713:Higher education 3544:Positive deviance 3539:Health psychology 3515:Health behavioral 3442:safety management 3416:Social distancing 3190:Population health 3170:Smoking cessation 3118:Pharmacovigilance 3089:Injury prevention 3057:Infection control 2975:Social psychology 2925:Prisoners' rights 2868:Medical sociology 2836:Public health law 2732:Biological hazard 2679: 2678: 2545:Hierarchy of life 2492:Plant systematics 2472:Molecular biology 2207:Falkow S (1988). 1899:Pasteur Institute 1641:Military Medicine 1230:Byrne JP (2012). 1057:(42): 6369–6372. 896:Alexander Fleming 854:Joseph Lister, UK 848:virulence factors 844:molecular version 799:Koch's postulates 707:St James's Parish 652:for studying the 385:Tommaso del Garbo 339:Persian physician 327: 176–178 AD 298:On Initial Causes 255: 56 BC 172:were caused by a 59:. It states that 53:scientific theory 3881: 3864:Biology theories 3839: 3838: 3827: 3826: 3815: 3814: 3709:Health education 3586: 3440:Food hygiene and 3421:Tropical disease 3233:Infant mortality 3208:Community health 3084:Controlled Drugs 3020:Health promotion 2950:Right to housing 2794:Health economics 2706: 2699: 2692: 2683: 2669: 2668: 2648:Natural theology 2384: 2377: 2370: 2361: 2318: 2317: 2315: 2313: 2295: 2261: 2255: 2254: 2253:on 3 March 2019. 2252: 2246:. Archived from 2213: 2204: 2198: 2197: 2187: 2155: 2149: 2148: 2138: 2114: 2108: 2107: 2097: 2073: 2067: 2066: 2045: 2039: 2038: 2036: 2034: 1994: 1988: 1987: 1979: 1973: 1972: 1954: 1922: 1916: 1915: 1913: 1911: 1890: 1881: 1880: 1874: 1872: 1842: 1836: 1835: 1833: 1831: 1814:(2nd ed.). 1805: 1794: 1793: 1775: 1731: 1725: 1722: 1716: 1715: 1705: 1673: 1667: 1666: 1656: 1632: 1626: 1625: 1623: 1621: 1599: 1590: 1589: 1587: 1585: 1579: 1548: 1542: 1541: 1523: 1517: 1516: 1480: 1474: 1473: 1458: 1452: 1451: 1449: 1447: 1429: 1423: 1422: 1420: 1418: 1370: 1364: 1363: 1361: 1359: 1353: 1306: 1300: 1299: 1297: 1295: 1273: 1267: 1266: 1258: 1252: 1251: 1227: 1221: 1220: 1217:Varro on Farming 1208: 1202: 1199:seeds of disease 1186: 1180: 1179: 1169: 1137: 1120: 1108: 1102: 1081: 1075: 1074: 1046: 1040: 1039: 1024: 1014: 1008: 1007: 977: 971: 970: 968: 966: 957:. Archived from 947: 890: 885: 884: 862:recognized that 754:swan neck flasks 747:mucous membranes 721:Louis Pasteur's 670:lower intestines 666:fecal–oral route 624:dinosaur fossils 572:Ignaz Semmelweis 393: 390: 382: 379: 370:pestifera semina 367: 364: 328: 325: 317: 314: 306: 303: 295: 292: 274: 271: 267: 264: 256: 253: 227:plague of Athens 224: 221: 217: 214: 185: 184: 179: 3891: 3890: 3884: 3883: 3882: 3880: 3879: 3878: 3854: 3853: 3852: 3847: 3799: 3770:Margaret Sanger 3738: 3697: 3581: 3579: 3573: 3516: 3510: 3482:Safety scandals 3441: 3435: 3357: 3351: 3285: 3279: 3275:Social medicine 3268:Race and health 3203:Child mortality 3184: 3143:Open defecation 3025:Human nutrition 3015:Family planning 3003:Behavior change 2989: 2945:Right to health 2858:Maternal health 2848:Health politics 2799:Health literacy 2715: 2710: 2680: 2675: 2657: 2638:Natural history 2579: 2517: 2511: 2467:Model organisms 2404: 2398: 2388: 2327: 2322: 2321: 2311: 2309: 2263: 2262: 2258: 2250: 2211: 2206: 2205: 2201: 2157: 2156: 2152: 2116: 2115: 2111: 2075: 2074: 2070: 2063: 2047: 2046: 2042: 2032: 2030: 1997:Koch R (1893). 1996: 1995: 1991: 1981: 1980: 1976: 1924: 1923: 1919: 1909: 1907: 1892: 1891: 1884: 1870: 1868: 1844: 1843: 1839: 1829: 1827: 1807: 1806: 1797: 1748:SAGE Publishing 1733: 1732: 1728: 1723: 1719: 1682:Medical History 1675: 1674: 1670: 1634: 1633: 1629: 1619: 1617: 1601: 1600: 1593: 1583: 1581: 1577: 1550: 1549: 1545: 1538: 1525: 1524: 1520: 1482: 1481: 1477: 1460: 1459: 1455: 1445: 1443: 1431: 1430: 1426: 1416: 1414: 1372: 1371: 1367: 1357: 1355: 1351: 1321:Florence, Italy 1308: 1307: 1303: 1293: 1291: 1275: 1274: 1270: 1260: 1259: 1255: 1248: 1229: 1228: 1224: 1210: 1209: 1205: 1201:into our body." 1187: 1183: 1146:Medical History 1139: 1138: 1123: 1109: 1105: 1100:Wayback Machine 1082: 1078: 1048: 1047: 1043: 1037: 1016: 1015: 1011: 1004: 979: 978: 974: 964: 962: 961:on 6 April 2016 949: 948: 944: 939: 931:Zymotic disease 886: 879: 876: 856: 787: 774:Nosema bombycis 715: 679:Vibrio cholerae 642: 636: 617: 591:puerperal fever 581:working at the 569: 544: 513: 508: 502: 478:Richard Bradley 428: 391: 380: 365: 335: 333:The Middle Ages 326: 315: 304: 293: 272: 265: 254: 247:De rerum natura 236:-like "seeds" ( 222: 215: 201: 199:Greece and Rome 196: 157: 139: 31:Vibrio cholerae 17: 12: 11: 5: 3889: 3888: 3885: 3877: 3876: 3871: 3866: 3856: 3855: 3849: 3848: 3846: 3845: 3833: 3821: 3808: 3805: 3804: 3801: 3800: 3798: 3797: 3792: 3787: 3782: 3777: 3772: 3767: 3762: 3757: 3752: 3746: 3744: 3740: 3739: 3737: 3736: 3735: 3734: 3729: 3724: 3719: 3711: 3705: 3703: 3699: 3698: 3696: 3695: 3688: 3683: 3678: 3677: 3676: 3671: 3666: 3661: 3653: 3652: 3651: 3646: 3638: 3637: 3636: 3628: 3627: 3626: 3621: 3613: 3612: 3611: 3603: 3602: 3601: 3592: 3590: 3583: 3578:Organizations, 3575: 3574: 3572: 3571: 3566: 3561: 3556: 3551: 3546: 3541: 3536: 3531: 3526: 3520: 3518: 3512: 3511: 3509: 3508: 3507: 3506: 3501: 3491: 3486: 3485: 3484: 3479: 3474: 3469: 3464: 3459: 3454: 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2811: 2801: 2796: 2791: 2789:Harm reduction 2786: 2781: 2776: 2771: 2770: 2769: 2764: 2754: 2749: 2744: 2739: 2734: 2729: 2723: 2721: 2717: 2716: 2711: 2709: 2708: 2701: 2694: 2686: 2677: 2676: 2674: 2673: 2662: 2659: 2658: 2656: 2655: 2650: 2645: 2640: 2635: 2630: 2625: 2620: 2615: 2610: 2605: 2604: 2603: 2593: 2587: 2585: 2581: 2580: 2578: 2577: 2572: 2567: 2562: 2557: 2552: 2547: 2542: 2537: 2532: 2527: 2521: 2519: 2513: 2512: 2510: 2509: 2504: 2499: 2494: 2489: 2484: 2479: 2474: 2469: 2464: 2459: 2454: 2449: 2444: 2439: 2434: 2429: 2424: 2419: 2414: 2408: 2406: 2400: 2399: 2389: 2387: 2386: 2379: 2372: 2364: 2358: 2357: 2348: 2338: 2326: 2325:External links 2323: 2320: 2319: 2256: 2199: 2150: 2109: 2088:(2): 175–195. 2068: 2061: 2040: 1989: 1974: 1917: 1882: 1837: 1820:John Churchill 1795: 1726: 1717: 1668: 1627: 1591: 1563:Lodi, Lombardy 1543: 1537:978-0028548807 1536: 1518: 1475: 1453: 1424: 1365: 1301: 1268: 1253: 1246: 1240:. p. 29. 1222: 1203: 1181: 1121: 1103: 1091: : 1–34; 1076: 1041: 1035: 1009: 1002: 972: 941: 940: 938: 935: 934: 933: 928: 926:Rudolf Virchow 923: 918: 913: 908: 903: 898: 892: 891: 888:Biology portal 875: 872: 855: 852: 840:Stanley Falkow 820: 819: 816: 813: 806: 786: 783: 714: 711: 703:Seething Wells 638:Main article: 635: 632: 620:Gideon Mantell 616: 613: 607:theories were 568: 565: 543: 540: 517:Agostino Bassi 512: 509: 504:Main article: 501: 498: 432:Francesco Redi 427: 424: 334: 331: 294: 200/216 200: 197: 195: 192: 153:Main article: 147:Robert Seymour 138: 135: 61:microorganisms 15: 13: 10: 9: 6: 4: 3: 2: 3887: 3886: 3875: 3872: 3870: 3867: 3865: 3862: 3861: 3859: 3844: 3843: 3834: 3832: 3831: 3822: 3820: 3819: 3810: 3809: 3806: 3796: 3793: 3791: 3788: 3786: 3783: 3781: 3778: 3776: 3773: 3771: 3768: 3766: 3765:Joseph Lister 3763: 3761: 3758: 3756: 3753: 3751: 3748: 3747: 3745: 3741: 3733: 3730: 3728: 3725: 3723: 3720: 3718: 3715: 3714: 3712: 3710: 3707: 3706: 3704: 3700: 3693: 3689: 3687: 3684: 3682: 3679: 3675: 3672: 3670: 3667: 3665: 3662: 3660: 3657: 3656: 3654: 3650: 3647: 3645: 3644:Health Canada 3642: 3641: 3639: 3635: 3632: 3631: 3629: 3625: 3622: 3620: 3617: 3616: 3614: 3610: 3607: 3606: 3604: 3600: 3597: 3596: 3594: 3593: 3591: 3589:Organizations 3587: 3584: 3576: 3570: 3567: 3565: 3562: 3560: 3557: 3555: 3552: 3550: 3547: 3545: 3542: 3540: 3537: 3535: 3532: 3530: 3527: 3525: 3522: 3521: 3519: 3513: 3505: 3502: 3500: 3497: 3496: 3495: 3492: 3490: 3487: 3483: 3480: 3478: 3475: 3473: 3470: 3468: 3465: 3463: 3460: 3458: 3455: 3453: 3450: 3449: 3447: 3446: 3444: 3438: 3432: 3429: 3427: 3426:Vaccine trial 3424: 3422: 3419: 3417: 3414: 3412: 3409: 3407: 3404: 3400: 3397: 3396: 3395: 3392: 3388: 3385: 3384: 3383: 3380: 3376: 3373: 3372: 3371: 3368: 3366: 3363: 3362: 3360: 3354: 3348: 3345: 3341: 3339: 3335: 3333: 3331: 3326: 3324: 3321: 3319: 3316: 3314: 3311: 3310: 3309: 3306: 3304: 3303:Relative risk 3301: 3299: 3296: 3294: 3291: 3290: 3288: 3282: 3276: 3273: 3269: 3266: 3264: 3263:Health equity 3261: 3259: 3256: 3255: 3254: 3251: 3249: 3246: 3244: 3241: 3239: 3236: 3234: 3231: 3229: 3228:Health system 3226: 3224: 3221: 3219: 3218:Global health 3216: 3214: 3211: 3209: 3206: 3204: 3201: 3199: 3198:Biostatistics 3196: 3195: 3193: 3191: 3187: 3181: 3178: 3176: 3173: 3171: 3168: 3166: 3163: 3159: 3156: 3154: 3151: 3149: 3146: 3144: 3141: 3139: 3136: 3134: 3131: 3130: 3129: 3126: 3124: 3121: 3119: 3116: 3112: 3109: 3108: 3107: 3104: 3100: 3097: 3095: 3092: 3090: 3087: 3085: 3082: 3080: 3077: 3075: 3072: 3071: 3070: 3067: 3063: 3060: 3058: 3055: 3053: 3050: 3048: 3045: 3044: 3043: 3040: 3036: 3033: 3031: 3028: 3027: 3026: 3023: 3021: 3018: 3016: 3013: 3009: 3006: 3005: 3004: 3001: 3000: 2998: 2996: 2992: 2986: 2983: 2981: 2978: 2976: 2973: 2971: 2968: 2966: 2963: 2961: 2958: 2956: 2953: 2951: 2948: 2946: 2943: 2941: 2940:Right to food 2938: 2936: 2933: 2931: 2928: 2926: 2923: 2919: 2916: 2914: 2911: 2909: 2906: 2904: 2901: 2899: 2896: 2895: 2894: 2891: 2889: 2886: 2884: 2881: 2878: 2874: 2873:Mental health 2871: 2869: 2866: 2864: 2861: 2859: 2856: 2854: 2851: 2849: 2846: 2842: 2839: 2837: 2834: 2833: 2832: 2829: 2827: 2824: 2822: 2821:Housing First 2819: 2815: 2812: 2810: 2809:Health system 2807: 2806: 2805: 2804:Health policy 2802: 2800: 2797: 2795: 2792: 2790: 2787: 2785: 2782: 2780: 2777: 2775: 2772: 2768: 2765: 2763: 2760: 2759: 2758: 2755: 2753: 2750: 2748: 2745: 2743: 2740: 2738: 2735: 2733: 2730: 2728: 2725: 2724: 2722: 2718: 2714: 2713:Public health 2707: 2702: 2700: 2695: 2693: 2688: 2687: 2684: 2672: 2664: 2663: 2660: 2654: 2651: 2649: 2646: 2644: 2641: 2639: 2636: 2634: 2631: 2629: 2626: 2624: 2621: 2619: 2616: 2614: 2611: 2609: 2606: 2602: 2599: 2598: 2597: 2594: 2592: 2589: 2588: 2586: 2582: 2576: 2573: 2571: 2568: 2566: 2563: 2561: 2558: 2556: 2553: 2551: 2548: 2546: 2543: 2541: 2538: 2536: 2533: 2531: 2528: 2526: 2523: 2522: 2520: 2514: 2508: 2505: 2503: 2500: 2498: 2495: 2493: 2490: 2488: 2485: 2483: 2480: 2478: 2475: 2473: 2470: 2468: 2465: 2463: 2460: 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Index


Scanning electron microscope
Vibrio cholerae
bacterium
cholera
scientific theory
diseases
microorganisms
pathogens
bacterium
protists
fungi
viruses
prions
viroids
infectious diseases
Girolamo Fracastoro
Marcus von Plenciz
Galen's
miasma theory
smallpox vaccination
Louis Pasteur
Robert Koch
bacteriology

Robert Seymour
Miasma theory
cholera
chlamydia infection
Black Death

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