204:, where he was hired as associate professor with tenure in 1987. Before his arrival in Michigan, he had ordered construction of a triple resonance probe for his new spectrometer. This allowed pulsing H, C, and N. After the probe was delivered in 1988, he developed triple resonance methods for conformation-independent sequential assignments of proteins. This has become the basis for today’s resonance assignments of proteins and structure determination of proteins in solution up to 50 kDa and above. Due to this achievement, Dr. Wagner was offered a full professorship, with tenure, by
185:. This became the foundation of solving protein structures in solution by NMR. The first structure he determined was for rabbit metallothioneine 2. When he and his team were ready to publish it, a crystal structure was reported for the same protein but was entirely different from his topology. After intensive scrutiny of his data it became clear that his structure was correct, and the crystal structure was not. This made the crystallographers aware of him, and he received offers for faculty positions at
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136:(Bio-NMR) and his research has been focused on protein structure, dynamics and stability, and on the relation of these to protein function. He is a structural biologist and is recognized for his work on the development of NMR spectroscopy for determination of protein structures in solution and characterizing protein dynamics.
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at the ETH in Zürich. There he continued to work on solution NMR of proteins. He learned about the nuclear
Overhauser effect (nOe) and developed procedures assigning specific NMR resonances to individual amino acids in the sequence of proteins. He was the first to completely assign the resonances of
152:
and ended up in
Southern Bavaria, where he grew up. Due to his school records he could go to a humanistic gymnasium, an institution that teaches classical antiquity specifically, and received an education with nine years of Latin and six years of classical Greek but also a good education in math and
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In 2017, a research team led by Wagner reported an improved design for tiny nanodiscs; synthetic models of cell membranes used to study proteins that control what enters and leaves a cell. The enhancements provide an unprecedented view of how viruses infect cells.
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Wagner, G.; Neuhaus, D.; Wörgötter, E.; Vasák, M.; Kägi, J. H.; Wüthrich, K. (1986-01-05). "Nuclear magnetic resonance identification of "half-turn" and 3(10)-helix secondary structure in rabbit liver metallothionein-2".
148:(now in the Czech Republic). He was the first to receive a college education in his family. Born to a blue-collar family, after World War II in the German-speaking part of Czechoslovakia, his family was
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Wagner, G.; DeMarco, A.; Wüthrich, K. (1976-08-23). "Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI). I. 1H NMR studies".
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Nasr, Mahmoud L.; Baptista, Diego; Strauss, Mike; Sun, Zhen-Yu J.; Grigoriu, Simina; Huser, Sonja; Plückthun, Andreas; Hagn, Franz; Walz, Thomas; Hogle, James M.; Wagner, Gerhard (January 2017).
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some physics. There, he had an excellent math/physics teacher and became fascinated with physics. Wagner was educated in a classical humanistic high school (humanistic
Gymnasium in Germany).
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Wagner studied
Physics at the Technical University in Munich with work on Mossbauer spectroscopy of iron-containing proteins. He pursued his PhD in Biophysics at the
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Gross, John D.; Moerke, Nathan J.; von der Haar, Tobias; Lugovskoy, Alexey A.; Sachs, Alan B.; McCarthy, John E. G.; Wagner, Gerhard (2003-12-12).
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of the mRNA begin the process of translation. In a 2003 Cell paper, Wagner’s lab reported the structure of the first two proteins in this complex,
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2005 Elected Member to
Deutsche Akademie der Naturforscher Leopoldina (German National Academy)
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where he graduated in 1977 with studies of protein dynamics, measuring rates of aromatic ring flips and hydrogen exchange.
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1999 Elected Fellow to
American Association for the Advancement of Science
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2004 Eastern
Analytical Symposium Achievement Award in Magnetic Resonance
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1997 The
Wellcome Lecture in Structural Biology, Kansas State University
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1995/96 Welcome
Visiting Professor in Basic Medical Sciences, Kansas State University
679:"Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E"
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2008 Elected Fellow to the
International Society of Magnetic Resonance
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2013 Elected member of the National Academy of Sciences (US)
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654:"SBGrid Consortium – Developer Tale – Gerhard Wagner – Harvard Medical School"
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After joining the Harvard faculty, he started research on the initiation of
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2003 The Cleveland Structural Biology Lecture
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2011 Stein and Moore Award of the Protein Society
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After graduation, he spent six months at the chemistry department of
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Professor of Biological Chemistry and Molecular Pharmacology at
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1970–1974 Fellowship Studienstiftung des Deutschen Volkes
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2013 Harvard-Australia Fellowship
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2011 Agilent Thought Leader Award
489:"Connell Lecture Series: Dr. Gerhard Wagner – Transcripts"
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He accepted the position at the University of Michigan in
101:(born 1945) is a German-American physicist. Currently the
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to bind to the 5’ end of mRNA and start making protein.
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American Society for Biochemistry and Molecular Biology
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1977 Zürich Protein Lecture, ETH Zürich
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2015 Elected member of the
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2012 Mill Hill Lecture 2012
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American Association for the Advancement of Science
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604:"Technology that Mimics Organelles in the Body"
464:"Technology that Mimics Organelles in the Body"
315:American Society for the Advancement of Science
115:German National Academy of Sciences Leopoldina
299:2018 Awarded the Gunther Laukien Prize.
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132:Wagner is considered one of the pioneers in
127:International Society of Magnetic Resonance
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176:. After this he went to the laboratory of
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906:"2018 Laukien Prize Winner Announcement"
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629:"2018 Laukien Prize Winner Announcement"
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510:Biophysics of Structure and Mechanism
295:American Academy of Arts and Sciences
119:American Academy of Arts and Sciences
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35:Wagner in 2011 giving an NMR lecture
183:basic pancreatic trypsin inhibitor
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947:People from Bor (Tachov District)
218:into a protein. After a gene is
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962:21st-century American physicists
832:"Agilent Thought Leader Program"
957:20th-century German physicists
952:Harvard Medical School faculty
416:"Gerhard Wagner, PhD – DF/HCC"
208:where he has been since 1990.
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696:10.1016/s0092-8674(03)00975-9
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857:"Prof. Gerhard Wagner's CV"
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16:German-American physicist
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195:University of Minnesota
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191:University of Michigan
107:Harvard Medical School
87:Harvard Medical School
220:transcribed into mRNA
181:an entire protein,
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304:Memberships
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172:to explore
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352:. aaas.org
336:References
193:, and the
163:ETH Zurich
56:Occupation
752:1548-7091
705:0092-8674
582:0022-2836
530:0340-1057
202:Ann Arbor
59:Physicist
770:27869813
713:14675538
546:40224988
236:ribosome
150:expelled
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590:3959079
400:May 13,
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224:5’ end
189:, the
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748:ISSN
709:PMID
701:ISSN
683:Cell
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538:9165
534:PMID
526:ISSN
402:2017
380:2017
358:2017
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187:Duke
125:and
41:Born
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