Knowledge (XXG)

Glial fibrillary acidic protein

Source 📝

1561: 302: 279: 176: 201: 553: 308: 207: 29: 1577: 55: 2391:
Bongcam-Rudloff E, Nistér M, Betsholtz C, Wang JL, Stenman G, Huebner K, et al. (March 1991). "Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes".
2532:"Molecular interactions in paracrystals of a fragment corresponding to the alpha-helical coiled-coil rod portion of glial fibrillary acidic protein: evidence for an antiparallel packing of molecules and polymorphism related to intermediate filament structure" 1329:
do not form filaments, the non-helical head and tail domains are necessary for filament formation. The head and tail regions have greater variability of sequence and structure. In spite of this increased variability, the head of GFAP contains two conserved
3630:
Lopez-Egido J, Cunningham J, Berg M, Oberg K, Bongcam-Rudloff E, Gobl A (August 2002). "Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity".
2057:
Buniatian G, Traub P, Albinus M, Beckers G, Buchmann A, Gebhardt R, Osswald H (January 1998). "The immunoreactivity of glial fibrillary acidic protein in mesangial cells and podocytes of the glomeruli of rat kidney in vivo and in culture".
1377:
by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow. There are different sets of kinases at work;
1932:
Isaacs A, Baker M, Wavrant-De Vrièze F, Hutton M (July 1998). "Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17".
2973:
Allen A, Gulhar S, Haidari R, Martinez JP, Bekenstein J, DeLorenzo R, et al. (January 2020). "Autoimmune glial fibrillary acidic protein astrocytopathy resulting in treatment-refractory flaccid paralysis".
2101:
Maunoury R, Portier MM, Léonard N, McCormick D (December 1991). "Glial fibrillary acidic protein immunoreactivity in adrenocortical and Leydig cells of the Syrian golden hamster (Mesocricetus auratus)".
3272:"Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability" 3227:
Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A (January 2001). "Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease".
2706:
Tardy M, Fages C, Le Prince G, Rolland B, Nunez J (1990). "Regulation of the Glial Fibrillary Acidic Protein (GFAP) and of its Encoding mRNA in the Developing Brain and in Cultured Astrocytes".
1809:(NSCs) and may be involved in migration. GFAP+1 is an antibody which labels two isoforms. Although GFAP+1 positive astrocytes are supposedly not reactive astrocytes, they have a wide variety of 2860:
Harrison BC, Mobley PL (January 1992). "Phosphorylation of glial fibrillary acidic protein and vimentin by cytoskeletal-associated intermediate filament protein kinase activity in astrocytes".
3600: 2014:
Roessmann U, Velasco ME, Sindely SD, Gambetti P (October 1980). "Glial fibrillary acidic protein (GFAP) in ependymal cells during development. An immunocytochemical study".
1769:(ECMO), children with abnormally high levels of GFAP were 13 times more likely to die and 11 times more likely to suffer brain injury than children with normal GFAP levels. 2798:"Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic processes in response to neurons" 2145:
Davidoff MS, Middendorff R, Köfüncü E, Müller D, Jezek D, Holstein AF (2002). "Leydig cells of the human testis possess astrocyte and oligodendrocyte marker molecules".
3324:"Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium" 315: 214: 3860: 3017:
Tomczak A, Su E, Tugizova M, Carlson AM, Kipp LB, Feng H, Han MH (December 2019). "A case of GFAP-astroglial autoimmunity presenting with reversible parkinsonism".
2930:
Paetau A, Elovaara I, Paasivuo R, Virtanen I, Palo J, Haltia M (1985). "Glial filaments are a major brain fraction in infantile neuronal ceroid-lipofuscinosis".
1971:
Jacque CM, Vinner C, Kujas M, Raoul M, Racadot J, Baumann NA (January 1978). "Determination of glial fibrillary acidic protein (GFAP) in human brain tumors".
1805:
in the human and rodent brain. These isoforms include GFAP kappa, GFAP +1 and the currently best researched GFAP delta. GFAP delta appears to be linked with
1813:
including processes of up to 0.95 mm (seen in the human brain). The expression of GFAP+1 positive astrocytes is linked with old age and the onset of
2903:
Tuccari G, Trombetta C, Giardinelli MM, Arena F, Barresi G (1986). "Distribution of glial fibrillary acidic protein in normal and gliotic human retina".
866: 1312:: in cells that express both proteins, two separate intermediate filament networks form, which can allow for specialization and increased variability. 847: 137: 3180:"Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response" 3451:"Down-regulation of glial fibrillary acidic protein expression during acute lytic varicella-zoster virus infection of cultured human astrocytes" 1397:
alone. This specificity of location allows for precise regulation of GFAP distribution to the daughter cells. Studies have also shown that GFAP
1762: 1662:
of GFAP have been shown to contribute to the accumulation of Rosenthal fibers. Some of these mutations have been proposed to be detrimental to
3608: 6175: 2723: 1914: 4488: 1896: 6185: 3754:
Cáceres-Marzal C, Vaquerizo J, Galán E, Fernández S (October 2006). "Early mitochondrial dysfunction in an infant with Alexander disease".
3501:"Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus" 301: 3853: 2844: 1766: 1548:
is the predominant clinical presentation of autoimmune GFAP astrocytopathy in published case series. It also can appear associated with
3109:
Smith ME, Eng LF (1987). "Glial fibrillary acidic protein in chronic relapsing experimental allergic encephalomyelitis in SJL/J mice".
1105: 3604: 1098: 1260:. The protein was named and first isolated and characterized by Lawrence F. Eng in 1969. In humans, it is located on the long arm of 278: 3392:"Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions" 1883: 1862: 1829: 3157: 2301:"Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal-astrocytic co-cultures" 5276: 5119: 3846: 1519: 1256:
as well as the shape of cells, but its exact function remains poorly understood, despite the number of studies using it as a
200: 175: 1879: 52: 6155: 5709: 2207:
Kasantikul V, Shuangshoti S (May 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma".
3793: 1858: 3363:
Cullen KM, Halliday GM (1994). "Chronic alcoholics have substantial glial pathology in the forebrain and diencephalon".
1690: 1494:
GFAP has also been shown to be important in repair after CNS injury. More specifically for its role in the formation of
117: 4416: 2180:
von Koskull H (1984). "Rapid identification of glial cells in human amniotic fluid with indirect immunofluorescence".
1778: 1560: 314: 213: 5887: 2348:
Eng LF, Ghirnikar RS, Lee YL (October 2000). "Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)".
1276:
sequence for the rod domain may differ between different type III intermediate filaments, but the structure of the
307: 206: 1674:
of cells with these mutations. GFAP therefore plays an important role in the pathogenesis of Alexander disease.
1440:, astrocytes lacking GFAP do not form the extensions usually present with neurons. Studies have also shown that 6120: 3811: 3668:"A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins" 3478: 2749:"GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination" 1597: 1219: 911: 125: 2614:
Venkatesh K, Srikanth L, Vengamma B, Chandrasekhar C, Sanjeevkumar A, Mouleshwara Prasad BC, Sarma PV (2013).
1410: 1754: 1464: 892: 3807: 1814: 1750: 1742: 1589: 1569: 1445: 1414: 1366:. It is involved in many important CNS processes, including cell communication and the functioning of the 1351: 1347: 1272:
Type III intermediate filaments contain three domains, named the head, rod and tail domains. The specific
1180: 4539: 3893: 1320: 1309: 1273: 1223: 1176: 189: 1797:
Although GFAP alpha is the only isoform which is able to assemble homomerically, GFAP has 8 different
4808: 3403: 2435: 1810: 104: 6115: 4748: 1545: 1367: 1253: 1192: 1077: 1056: 1048: 1044: 1014: 993: 989: 985: 3322:
Johnston-Wilson NL, Sims CD, Hofmann JP, Anderson L, Shore AD, Torrey EF, Yolken RH (March 2000).
1491:
transduction of signals. These data highlight the importance of GFAP for cell-cell communication.
4568: 4198: 3732: 3582: 3252: 3134: 3042: 2999: 2955: 2885: 2778: 2373: 2232: 2127: 2083: 2039: 1996: 1758: 1651: 1316: 149: 3802: 1723: 1081: 1052: 1018: 981: 2579:
Fuchs E, Weber K (1994). "Intermediate filaments: structure, dynamics, function, and disease".
2250:
Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, et al. (July 1998).
1749:
of acute injury to the brain and spinal cord in different types of disease mechanisms, such as
6180: 5966: 5669: 4330: 3818: 3771: 3724: 3689: 3648: 3574: 3530: 3470: 3431: 3372: 3345: 3301: 3244: 3209: 3126: 3091: 3034: 2991: 2947: 2912: 2877: 2827: 2770: 2729: 2719: 2688: 2637: 2596: 2561: 2512: 2463: 2401: 2365: 2330: 2281: 2224: 2189: 2162: 2119: 2075: 2031: 1988: 1950: 1735: 1711: 1686: 1643: 1631: 1612: 1549: 1444:
in GFAP knockout mice do not exhibit normal structure, and these mice demonstrate deficits in
1355: 97: 45: 5689: 2747:
Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, Raine CS (October 1996).
5914: 5621: 5606: 5601: 5596: 5591: 5581: 5502: 5211: 5191: 5161: 5156: 5038: 4393: 4388: 3763: 3716: 3679: 3640: 3564: 3520: 3512: 3462: 3421: 3411: 3335: 3291: 3283: 3236: 3199: 3191: 3118: 3081: 3073: 3026: 2983: 2939: 2869: 2817: 2809: 2760: 2711: 2678: 2668: 2627: 2588: 2551: 2543: 2502: 2494: 2453: 2443: 2357: 2320: 2312: 2271: 2263: 2216: 2154: 2111: 2067: 2023: 1980: 1942: 1806: 1731: 1715: 1682: 1623:
to re-establish the glial margins around the central injury core and is partially caused by
1603:
There are multiple disorders associated with improper GFAP regulation, and injury can cause
1480: 1476: 394: 325: 269: 224: 5831: 5826: 5821: 5816: 5571: 5561: 5551: 5546: 5517: 5221: 5216: 4263: 4151: 4141: 4116: 4096: 4000: 3980: 3062:"Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord" 2655:
Sjölin K, Kultima K, Larsson A, Freyhult E, Zjukovskaja C, Alkass K, Burman J (June 2022).
1350:
in astrocyte cells, and the concentration of GFAP differs between different regions in the
6056: 4670: 4520: 4403: 4223: 3797: 3551:
Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D'Anna L, Huss A, et al. (March 2022).
2252:"Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture" 1707: 1655: 1394: 552: 369: 145: 2483:"Sorting out IF networks: consequences of domain swapping on IF recognition and assembly" 3767: 3407: 2592: 2439: 6019: 5882: 4579: 4410: 3919: 3525: 3516: 3500: 3296: 3271: 3204: 3179: 3086: 3061: 2873: 2822: 2797: 2683: 2656: 2556: 2531: 2507: 2482: 2325: 2300: 2276: 2251: 1697: 1620: 1608: 1539: 1484: 1441: 1429: 1398: 1304:
with other type III proteins. GFAP and other type III IF proteins cannot assemble with
1301: 1188: 2765: 2748: 2458: 2423: 2071: 1757:. Elevated blood levels of GFAP are also found in neuroinflammatory diseases, such as 1292:
of each filament aligned. Type III filaments such as GFAP are capable of forming both
781: 776: 771: 766: 761: 756: 751: 746: 741: 736: 731: 726: 721: 716: 700: 695: 690: 685: 680: 675: 670: 665: 660: 655: 650: 645: 640: 635: 619: 614: 609: 604: 599: 594: 6169: 6083: 6078: 5043: 4913: 4862: 4812: 4752: 4674: 4642: 4583: 4369: 3888: 3827: 3586: 3426: 3391: 3046: 3003: 2115: 2027: 1984: 1727: 1659: 1624: 1437: 1281: 1280:
is highly conserved. This rod domain coils around that of another filament to form a
1261: 581: 3736: 3720: 3666:
Nielsen AL, Holm IE, Johansen M, Bonven B, Jørgensen P, Jørgensen AL (August 2002).
3256: 3138: 2889: 2782: 2236: 2087: 2043: 2000: 5927: 4982: 4737: 4281: 3873: 3195: 3153: 2959: 2377: 2316: 2131: 1719: 1700: 1663: 1406: 1297: 1246: 1207: 387: 166: 5899: 5877: 2657:"Distribution of five clinically important neuroglial proteins in the human brain" 2424:"Molecular cloning and primary structure of human glial fibrillary acidic protein" 129: 1634:, a rare genetic disorder. Its symptoms include mental and physical retardation, 1615:
conditions, as well as injury that severs neural material. The scar is formed by
153: 6073: 6024: 5894: 5784: 5114: 4558: 4513: 4432: 4354: 3902: 3287: 3030: 2987: 2715: 2710:. Advances in Experimental Medicine and Biology. Vol. 265. pp. 41–52. 1919:
National Center for Biotechnology Information, U.S. National Library of Medicine
1901:
National Center for Biotechnology Information, U.S. National Library of Medicine
1604: 1581: 1565: 1531: 1402: 1363: 1359: 1257: 1215: 1203: 1199: 3838: 3569: 3552: 3396:
Proceedings of the National Academy of Sciences of the United States of America
2673: 2428:
Proceedings of the National Academy of Sciences of the United States of America
470: 6125: 6044: 6034: 5922: 5033: 5012: 4778: 4715: 4710: 4705: 4685: 4660: 4648: 4634: 4629: 4624: 4619: 4614: 4609: 4604: 4599: 4594: 4456: 4338: 4327: 4313: 3929: 3790: 2361: 1835: 1639: 1527: 1495: 1460: 1293: 1289: 1285: 1242: 1230: 286: 183: 133: 2632: 2615: 1765:, a disease targeting astrocytes. In a study of 22 child patients undergoing 5954: 5949: 5944: 5904: 5742: 5737: 5732: 5090: 5070: 4725: 4720: 4700: 4695: 4690: 4680: 4589: 4493: 4427: 2448: 2158: 1817: 1802: 1746: 1671: 1667: 1647: 1616: 1488: 1472: 1421: 1250: 1211: 1184: 811: 530: 408: 353: 340: 252: 239: 141: 3775: 3728: 3693: 3684: 3667: 3652: 3644: 3578: 3466: 3416: 3349: 3305: 3248: 3213: 3095: 3038: 2995: 2813: 2692: 2641: 2498: 2369: 2334: 2220: 2166: 1946: 1413:. These data suggest that GFAP is necessary for many critical roles in the 3534: 3474: 3435: 3376: 3340: 3323: 3130: 3122: 2951: 2916: 2881: 2831: 2774: 2733: 2600: 2565: 2547: 2516: 2467: 2405: 2285: 2228: 2193: 2123: 2079: 2035: 1954: 1145: 1140: 28: 6068: 6029: 5961: 5934: 5801: 5789: 5664: 5659: 5100: 5095: 5017: 4451: 4446: 4308: 2267: 1992: 1798: 1678: 1635: 1585: 1523: 1515: 1433: 1386: 1335: 1331: 1325: 1305: 1234: 1129: 956: 937: 3601:"Protein Found to Predict Brain Injury in Children on ECMO Life Support" 3553:"Blood GFAP as an emerging biomarker in brain and spinal cord disorders" 3390:
Levi G, Patrizio M, Bernardo A, Petrucci TC, Agresti C (February 1993).
3077: 2616:"In vitro differentiation of cultured human CD34+ cells into astrocytes" 6095: 6049: 5939: 5869: 5838: 5768: 5763: 5727: 5722: 5717: 5684: 5654: 5649: 5644: 5639: 5324: 5256: 5251: 5246: 5241: 5236: 5128: 5065: 4553: 4498: 4439: 4422: 4383: 3869: 3832: 3822: 2943: 1689:. Additionally, reduction in GFAP expression has also been reported in 1576: 1456: 1374: 1277: 1196: 1165: 923: 878: 74: 6014: 5996: 5991: 5986: 5981: 5971: 5806: 5699: 5694: 5679: 5674: 5586: 5532: 5497: 5472: 5467: 5462: 5457: 5447: 5442: 5432: 5417: 5412: 5294: 5289: 5284: 5196: 5186: 5166: 5151: 5146: 5141: 5136: 5002: 4773: 4768: 4525: 4191: 4186: 4176: 3954: 1535: 1468: 1425: 1409:
structure deterioration, and functional/structural impairment of the
1390: 1382: 1245:, which are all involved in the structure and function of the cell's 1238: 1113: 833: 3450: 1592:, so the astrocyte appears yellow. Nuclear DNA is stained blue with 1315:
To form networks, the initial GFAP dimers combine to make staggered
1448:
such as the eye-blink task. Biochemical studies of GFAP have shown
6039: 5811: 5794: 5631: 5626: 5616: 5611: 5576: 5566: 5556: 5541: 5522: 5512: 5507: 5492: 5487: 5482: 5477: 5452: 5437: 5427: 5422: 5407: 5402: 5382: 5377: 5372: 5367: 5362: 5357: 5352: 5347: 5342: 5337: 5332: 5304: 5299: 5266: 5261: 5231: 5226: 5206: 5201: 5181: 5171: 5086: 4964: 4959: 4954: 4949: 4944: 4939: 4934: 4929: 4924: 4919: 4903: 4898: 4893: 4888: 4883: 4878: 4873: 4868: 4843: 4838: 4833: 4828: 4823: 4818: 4798: 4793: 4788: 4783: 4763: 4758: 4468: 4398: 4347: 4344: 4341: 4333: 4322: 4319: 4316: 4301: 4296: 4291: 4286: 4258: 4248: 4233: 4166: 4156: 4136: 4111: 4106: 4091: 4081: 4076: 4071: 4066: 4061: 4056: 4041: 3995: 3990: 3985: 3975: 3970: 3965: 3944: 3939: 3934: 3924: 3911: 3240: 1786: 1703: 1694: 1575: 1559: 1503: 1449: 3707:
Middeldorp J, Hol EM (March 2011). "GFAP in health and disease".
1338:
residue that have been shown to be required for proper assembly.
796: 792: 6140: 6135: 6130: 6090: 6061: 5976: 5853: 5848: 5843: 5747: 5397: 5392: 5387: 5314: 5309: 5176: 5058: 5053: 5048: 4508: 4503: 4461: 4374: 4364: 4359: 4253: 4243: 4238: 4228: 4218: 4213: 4208: 4203: 4126: 4051: 4046: 4036: 4031: 4026: 4021: 4016: 4011: 2848: 2708:
Molecular Aspects of Development and Aging of the Nervous System
1782: 1593: 1379: 1191:
during development. GFAP has also been found to be expressed in
1172: 121: 3842: 3270:
Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD (October 2011).
561: 3449:
Kennedy PG, Major EO, Williams RK, Straus SE (December 1994).
1584:
of an astrocyte in cell culture in red and counterstained for
1514:
In 2016 a CNS inflammatory disorder associated with anti-GFAP
1499: 1498:
in a multitude of locations throughout the CNS including the
1179:(IF) protein that is expressed by numerous cell types of the 3817:
Overview of all the structural information available in the
1522:
developed meningoencephalomyelitis with inflammation of the
1646:. The cellular mechanism of the disease is the presence of 1401:
undergo multiple degenerative processes including abnormal
2422:
Reeves SA, Helman LJ, Allison A, Israel MA (July 1989).
1710:
of GFAP and GFAP levels can be decreased in response to
1534:. About one third of cases were associated with various 377: 1596:. Antibodies, cell preparation and image generated by 1588:
in green. GFAP and vimentin colocalize in cytoplasmic
1722:. Decreases in GFAP expression have been reported in 542: 732:
negative regulation of neuron projection development
6108: 6007: 5913: 5868: 5777: 5756: 5708: 5531: 5323: 5275: 5127: 5113: 5079: 5026: 4995: 4975: 4854: 4736: 4567: 4549: 4538: 4481: 4274: 3953: 3910: 3901: 3887: 3880: 3066:
The Journal of Biophysical and Biochemical Cytology
1070: 1037: 1007: 974: 485:
dentate gyrus of hippocampal formation granule cell
3791:GeneReviews/NCBI/NIH/UW entry on Alexander disease 3317: 3315: 3178:Hagemann TL, Connor JX, Messing A (October 2006). 2796:Weinstein DE, Shelanski ML, Liem RK (March 1991). 1875: 1873: 1871: 1854: 1852: 1850: 1777:Glial fibrillary acidic protein has been shown to 1206:of the testis in both hamsters and humans, human 727:positive regulation of Schwann cell proliferation 717:regulation of protein-containing complex assembly 324: 223: 3499:Rinaman L, Card JP, Enquist LW (February 1993). 2481:McCormick MB, Coulombe PA, Fuchs E (June 1991). 1745:has led to a great interest in GFAP as a blood 1229:GFAP is closely related to the other three non- 767:positive regulation of glial cell proliferation 2849:Glial Fibrillary Acidic Protein, GFAP - 137780 1880:GRCm38: Ensembl release 89: ENSMUSG00000020932 1681:have been reported to decrease in response to 1630:Another condition directly related to GFAP is 3854: 2299:Cullen DK, Simon CM, LaPlaca MC (July 2007). 8: 2530:Stewart M, Quinlan RA, Moir RD (July 1989). 1966: 1964: 1741:The generally high abundance of GFAP in the 1859:GRCh38: Ensembl release 89: ENSG00000131095 5124: 4564: 4546: 3907: 3898: 3884: 3861: 3847: 3839: 807: 777:regulation of chaperone-mediated autophagy 577: 365: 264: 161: 63: 3831:(Glial fibrillary acidic protein) at the 3810:at the U.S. National Library of Medicine 3683: 3568: 3524: 3425: 3415: 3339: 3295: 3203: 3085: 2821: 2764: 2682: 2672: 2631: 2555: 2506: 2457: 2447: 2324: 2275: 108:, ALXDRD, glial fibrillary acidic protein 3019:Multiple Sclerosis and Related Disorders 2976:Multiple Sclerosis and Related Disorders 1670:activity, which would lead to increased 1354:, where the highest levels are found in 1846: 1801:which label distinct subpopulations of 3060:Bunge MB, Bunge RP, Ris H (May 1961). 1373:GFAP has been shown to play a role in 1342:Function in the central nervous system 1249:. GFAP is thought to help to maintain 696:cytoplasmic side of lysosomal membrane 615:structural constituent of cytoskeleton 18: 16:Type III intermediate filament protein 3546: 3544: 2417: 2415: 1677:Notably, the expression of some GFAP 1642:(stiffness of arms and/or legs), and 1638:, enlargement of the brain and head, 1319:, which are the basic subunits of an 757:regulation of neurotransmitter uptake 329: 290: 285: 228: 187: 182: 7: 1973:Journal of the Neurological Sciences 1666:formation as well as an increase in 3768:10.1016/j.pediatrneurol.2006.03.010 3672:The Journal of Biological Chemistry 2845:Online Mendelian Inheritance in Man 2593:10.1146/annurev.bi.63.070194.002021 1767:extracorporeal membrane oxygenation 1420:GFAP is proposed to play a role in 762:Bergmann glial cell differentiation 752:intermediate filament-based process 419:dorsal motor nucleus of vagus nerve 3607:. 19 November 2010. Archived from 3517:10.1523/JNEUROSCI.13-02-00685.1993 2874:10.1111/j.1471-4159.1992.tb09313.x 1650:accumulations containing GFAP and 1538:and many also expressed other CNS 1067: 1034: 1004: 971: 947: 928: 902: 883: 857: 838: 782:intermediate filament organization 656:intracellular anatomical structure 547: 465: 403: 382: 14: 3803:OMIM entries on Alexander disease 742:extracellular matrix organization 4489:Wiskott–Aldrich syndrome protein 3156:. Medical College of Wisconsin. 3111:Journal of Neuroscience Research 2905:Basic and Applied Histochemistry 551: 493:lumbar subsegment of spinal cord 313: 306: 300: 277: 212: 205: 199: 174: 27: 5710:Microtubule organising proteins 3808:Glial Fibrillary Acidic Protein 3721:10.1016/j.pneurobio.2011.01.005 3605:Johns Hopkins Children's Center 3481:from the original on 2021-04-27 3160:from the original on 2007-02-24 1830:17q21.31 microdeletion syndrome 1158:Glial fibrillary acidic protein 3196:10.1523/JNEUROSCI.3260-06.2006 2317:10.1016/j.brainres.2007.04.070 1607:to react in detrimental ways. 1520:autoimmune GFAP astrocytopathy 1510:Autoimmune GFAP astrocytopathy 1177:type III intermediate filament 747:neuron projection regeneration 562:More reference expression data 531:More reference expression data 1: 5757:Microtubule severing proteins 2766:10.1016/S0896-6273(00)80194-4 2581:Annual Review of Biochemistry 2072:10.1016/s0248-4900(98)80232-3 1518:was described. Patients with 1389:transition, while other GFAP 298: 197: 6176:Genes on human chromosome 17 4417:actin depolymerizing factors 2209:Journal of Surgical Oncology 2116:10.1016/0165-5728(91)90167-6 2028:10.1016/0006-8993(80)91090-2 1985:10.1016/0022-510x(78)90107-7 1611:is a consequence of several 1233:type III IF family members, 595:structural molecule activity 6186:Biology of bipolar disorder 5895:Plakoglobin (gamma catenin) 3505:The Journal of Neuroscience 3288:10.1016/j.yexcr.2011.06.017 3184:The Journal of Neuroscience 3031:10.1016/j.msard.2019.101900 2988:10.1016/j.msard.2019.101924 2802:The Journal of Cell Biology 2716:10.1007/978-1-4757-5876-4_4 2536:The Journal of Cell Biology 2487:The Journal of Cell Biology 1487:that are important for the 435:superior vestibular nucleus 6202: 3633:Experimental Cell Research 3570:10.1038/s41582-021-00616-3 3276:Experimental Cell Research 2674:10.1186/s13041-022-00935-6 2104:Journal of Neuroimmunology 1832:(Koolen–de Vries syndrome) 1323:. Since rod domains alone 1218:and stellate cells of the 1106:Chr 11: 102.78 – 102.79 Mb 6151: 3557:Nature Reviews. Neurology 3152:HealthLink (2007-11-25). 2862:Journal of Neurochemistry 1915:"Mouse PubMed Reference:" 1897:"Human PubMed Reference:" 1706:can directly inhibit the 1691:Wernicke's encephalopathy 1346:GFAP is expressed in the 1144: 1139: 1135: 1128: 1112: 1093: 1074: 1041: 1030: 1011: 978: 967: 954: 950: 935: 931: 922: 909: 905: 890: 886: 877: 864: 860: 845: 841: 832: 817: 810: 806: 790: 605:identical protein binding 580: 576: 559: 550: 541: 528: 477: 468: 415: 406: 376: 368: 364: 347: 334: 297: 276: 267: 263: 246: 233: 196: 173: 164: 160: 115: 112: 102: 95: 90: 71: 66: 49: 44: 39: 35: 26: 21: 6121:Prokaryotic cytoskeleton 3812:Medical Subject Headings 3709:Progress in Neurobiology 2633:10.4103/0028-3886.117615 1598:EnCor Biotechnology Inc. 1446:conditioning experiments 1428:interactions as well as 1202:taken from rat kidneys, 431:external globus pallidus 423:inferior olivary nucleus 2449:10.1073/pnas.86.13.5178 2362:10.1023/A:1007677003387 2159:10.1078/0065-1281-00630 1755:cerebrovascular disease 1430:cell-cell communication 1168:that is encoded by the 1099:Chr 17: 44.9 – 44.92 Mb 3685:10.1074/jbc.M112121200 3645:10.1006/excr.2002.5575 3467:10.1006/viro.1994.1679 3417:10.1073/pnas.90.4.1541 3365:Alcohol and Alcoholism 2814:10.1083/jcb.112.6.1205 2499:10.1083/jcb.113.5.1111 2350:Neurochemical Research 2221:10.1002/jso.2930410109 1947:10.1006/geno.1998.5360 1751:traumatic brain injury 1714:infection with HIV-1, 1600: 1590:intermediate filaments 1573: 1570:anaplastic astrocytoma 1348:central nervous system 1310:intermediate filaments 1181:central nervous system 772:long-term potentiation 427:ventral tegmental area 331:11 E1|11 66.48 cM 4741:(hard alpha-keratins) 4572:(soft alpha-keratins) 3341:10.1038/sj.mp.4000696 3123:10.1002/jnr.490180129 2932:Acta Neuropathologica 2548:10.1083/jcb.109.1.225 1579: 1568:in a glial neoplasm ( 1563: 1321:intermediate filament 737:astrocyte development 681:glial cell projection 651:intermediate filament 517:primary visual cortex 292:Chromosome 11 (mouse) 190:Chromosome 17 (human) 6156:cytoskeletal defects 6116:Major sperm proteins 3328:Molecular Psychiatry 2268:10.1136/gut.43.1.128 1763:neuromyelitis optica 1360:cervical spinal cord 1308:, the type I and II 722:response to wounding 686:astrocyte projection 67:List of PDB id codes 40:Available structures 4569:Epithelial keratins 3756:Pediatric Neurology 3678:(33): 29983–29991. 3408:1993PNAS...90.1541L 3190:(43): 11162–11173. 3154:"Alexander Disease" 3078:10.1083/jcb.10.1.67 2440:1989PNAS...86.5178R 2356:(9–10): 1439–1451. 2060:Biology of the Cell 1658:. Mutations in the 1652:heat shock proteins 1546:Meningoencephalitis 1411:blood–brain barrier 1368:blood brain barrier 1254:mechanical strength 1175:in humans. It is a 509:superior colliculus 501:ganglion cell layer 447:subthalamic nucleus 3796:2017-01-18 at the 2944:10.1007/bf00686997 1759:multiple sclerosis 1601: 1574: 1552:and parkinsonism. 1393:are active at the 912:ENSMUSG00000020932 710:Biological process 691:astrocyte end-foot 629:Cellular component 588:Molecular function 497:supraoptic nucleus 6163: 6162: 6104: 6103: 5864: 5863: 5109: 5108: 4991: 4990: 4534: 4533: 4477: 4476: 3282:(16): 2252–2266. 2725:978-1-4757-5878-8 2434:(13): 5178–5182. 2147:Acta Histochemica 1807:neural stem cells 1687:neurodegeneration 1632:Alexander disease 1619:interacting with 1613:neurodegenerative 1550:encephalomyelitis 1385:acts only at the 1356:medulla oblongata 1183:(CNS), including 1155: 1154: 1151: 1150: 1124: 1123: 1089: 1088: 1064: 1063: 1026: 1025: 1001: 1000: 963: 962: 944: 943: 918: 917: 899: 898: 873: 872: 854: 853: 802: 801: 572: 571: 568: 567: 537: 536: 524: 523: 462: 461: 360: 359: 259: 258: 86: 85: 82: 81: 50:Ortholog search: 6193: 5125: 4565: 4547: 3908: 3899: 3885: 3863: 3856: 3849: 3840: 3779: 3741: 3740: 3704: 3698: 3697: 3687: 3663: 3657: 3656: 3627: 3621: 3620: 3618: 3616: 3597: 3591: 3590: 3572: 3548: 3539: 3538: 3528: 3496: 3490: 3489: 3487: 3486: 3446: 3440: 3439: 3429: 3419: 3402:(4): 1541–1545. 3387: 3381: 3380: 3360: 3354: 3353: 3343: 3319: 3310: 3309: 3299: 3267: 3261: 3260: 3224: 3218: 3217: 3207: 3175: 3169: 3168: 3166: 3165: 3149: 3143: 3142: 3106: 3100: 3099: 3089: 3057: 3051: 3050: 3014: 3008: 3007: 2970: 2964: 2963: 2938:(3–4): 190–194. 2927: 2921: 2920: 2900: 2894: 2893: 2857: 2851: 2842: 2836: 2835: 2825: 2808:(6): 1205–1213. 2793: 2787: 2786: 2768: 2744: 2738: 2737: 2703: 2697: 2696: 2686: 2676: 2652: 2646: 2645: 2635: 2611: 2605: 2604: 2576: 2570: 2569: 2559: 2527: 2521: 2520: 2510: 2493:(5): 1111–1124. 2478: 2472: 2471: 2461: 2451: 2419: 2410: 2409: 2400:(5): 1553–1560. 2388: 2382: 2381: 2345: 2339: 2338: 2328: 2296: 2290: 2289: 2279: 2247: 2241: 2240: 2204: 2198: 2197: 2177: 2171: 2170: 2142: 2136: 2135: 2110:(1–3): 119–129. 2098: 2092: 2091: 2054: 2048: 2047: 2011: 2005: 2004: 1968: 1959: 1958: 1929: 1923: 1922: 1911: 1905: 1904: 1893: 1887: 1877: 1866: 1856: 1732:bipolar disorder 1716:varicella zoster 1656:Rosenthal fibers 1137: 1136: 1108: 1101: 1084: 1068: 1059: 1035: 1031:RefSeq (protein) 1021: 1005: 996: 972: 948: 929: 903: 884: 858: 839: 808: 610:integrin binding 578: 564: 555: 548: 533: 473: 471:Top expressed in 466: 411: 409:Top expressed in 404: 383: 366: 356: 343: 332: 317: 310: 304: 293: 281: 265: 255: 242: 231: 216: 209: 203: 192: 178: 162: 156: 154:GFAP - orthologs 107: 100: 77: 64: 58: 37: 36: 31: 19: 6201: 6200: 6196: 6195: 6194: 6192: 6191: 6190: 6166: 6165: 6164: 6159: 6147: 6100: 6003: 5909: 5860: 5773: 5752: 5704: 5527: 5319: 5271: 5117: 5105: 5075: 5022: 4987: 4971: 4855:Ungrouped alpha 4850: 4740: 4732: 4571: 4557: 4551: 4541: 4530: 4473: 4270: 3949: 3891: 3876: 3867: 3798:Wayback Machine 3787: 3782: 3753: 3749: 3747:Further reading 3744: 3706: 3705: 3701: 3665: 3664: 3660: 3629: 3628: 3624: 3614: 3612: 3611:on 9 March 2012 3599: 3598: 3594: 3550: 3549: 3542: 3498: 3497: 3493: 3484: 3482: 3448: 3447: 3443: 3389: 3388: 3384: 3362: 3361: 3357: 3321: 3320: 3313: 3269: 3268: 3264: 3229:Nature Genetics 3226: 3225: 3221: 3177: 3176: 3172: 3163: 3161: 3151: 3150: 3146: 3108: 3107: 3103: 3059: 3058: 3054: 3016: 3015: 3011: 2972: 2971: 2967: 2929: 2928: 2924: 2902: 2901: 2897: 2859: 2858: 2854: 2843: 2839: 2795: 2794: 2790: 2746: 2745: 2741: 2726: 2705: 2704: 2700: 2661:Molecular Brain 2654: 2653: 2649: 2620:Neurology India 2613: 2612: 2608: 2578: 2577: 2573: 2529: 2528: 2524: 2480: 2479: 2475: 2421: 2420: 2413: 2394:Cancer Research 2390: 2389: 2385: 2347: 2346: 2342: 2298: 2297: 2293: 2249: 2248: 2244: 2206: 2205: 2201: 2182:Acta Cytologica 2179: 2178: 2174: 2144: 2143: 2139: 2100: 2099: 2095: 2056: 2055: 2051: 2013: 2012: 2008: 1970: 1969: 1962: 1931: 1930: 1926: 1913: 1912: 1908: 1895: 1894: 1890: 1878: 1869: 1857: 1848: 1844: 1826: 1795: 1775: 1724:Down's syndrome 1708:phosphorylation 1558: 1512: 1465:phosphorylation 1453: 1395:cleavage furrow 1344: 1270: 1189:ependymal cells 1146:View/Edit Mouse 1141:View/Edit Human 1104: 1097: 1094:Location (UCSC) 1080: 1076: 1055: 1051: 1047: 1043: 1017: 1013: 992: 988: 984: 980: 893:ENSG00000131095 786: 705: 666:cell projection 624: 600:protein binding 560: 529: 520: 515: 511: 507: 505:median eminence 503: 499: 495: 491: 487: 483: 469: 458: 455:pars reticulata 453: 449: 445: 441: 437: 433: 429: 425: 421: 407: 351: 338: 330: 320: 319: 318: 311: 291: 268:Gene location ( 250: 237: 229: 219: 218: 217: 210: 188: 165:Gene location ( 116: 103: 96: 73: 51: 17: 12: 11: 5: 6199: 6197: 6189: 6188: 6183: 6178: 6168: 6167: 6161: 6160: 6152: 6149: 6148: 6146: 6145: 6144: 6143: 6138: 6133: 6128: 6118: 6112: 6110: 6106: 6105: 6102: 6101: 6099: 6098: 6093: 6088: 6087: 6086: 6081: 6071: 6066: 6065: 6064: 6054: 6053: 6052: 6047: 6042: 6037: 6032: 6027: 6022: 6020:Corneodesmosin 6011: 6009: 6005: 6004: 6002: 6001: 6000: 5999: 5994: 5989: 5984: 5979: 5974: 5969: 5959: 5958: 5957: 5952: 5947: 5937: 5932: 5931: 5930: 5919: 5917: 5911: 5910: 5908: 5907: 5902: 5897: 5892: 5891: 5890: 5880: 5874: 5872: 5866: 5865: 5862: 5861: 5859: 5858: 5857: 5856: 5851: 5846: 5836: 5835: 5834: 5829: 5824: 5819: 5814: 5804: 5799: 5798: 5797: 5787: 5781: 5779: 5775: 5774: 5772: 5771: 5766: 5760: 5758: 5754: 5753: 5751: 5750: 5745: 5740: 5735: 5730: 5725: 5720: 5714: 5712: 5706: 5705: 5703: 5702: 5697: 5692: 5687: 5682: 5677: 5672: 5667: 5662: 5657: 5652: 5647: 5642: 5635: 5634: 5629: 5624: 5619: 5614: 5609: 5604: 5599: 5594: 5589: 5584: 5579: 5574: 5569: 5564: 5559: 5554: 5549: 5544: 5537: 5535: 5529: 5528: 5526: 5525: 5520: 5515: 5510: 5505: 5500: 5495: 5490: 5485: 5480: 5475: 5470: 5465: 5460: 5455: 5450: 5445: 5440: 5435: 5430: 5425: 5420: 5415: 5410: 5405: 5400: 5395: 5390: 5385: 5380: 5375: 5370: 5365: 5360: 5355: 5350: 5345: 5340: 5335: 5329: 5327: 5321: 5320: 5318: 5317: 5312: 5307: 5302: 5297: 5292: 5287: 5281: 5279: 5273: 5272: 5270: 5269: 5264: 5259: 5254: 5249: 5244: 5239: 5234: 5229: 5224: 5219: 5214: 5209: 5204: 5199: 5194: 5189: 5184: 5179: 5174: 5169: 5164: 5159: 5154: 5149: 5144: 5139: 5133: 5131: 5122: 5111: 5110: 5107: 5106: 5104: 5103: 5098: 5093: 5087:Nuclear lamins 5083: 5081: 5077: 5076: 5074: 5073: 5068: 5063: 5062: 5061: 5056: 5051: 5041: 5036: 5030: 5028: 5024: 5023: 5021: 5020: 5015: 5010: 5005: 4999: 4997: 4993: 4992: 4989: 4988: 4986: 4985: 4979: 4977: 4973: 4972: 4970: 4969: 4968: 4967: 4962: 4957: 4952: 4947: 4942: 4937: 4932: 4927: 4922: 4909: 4908: 4907: 4906: 4901: 4896: 4891: 4886: 4881: 4876: 4871: 4858: 4856: 4852: 4851: 4849: 4848: 4847: 4846: 4841: 4836: 4831: 4826: 4821: 4804: 4803: 4802: 4801: 4796: 4791: 4786: 4781: 4776: 4771: 4766: 4761: 4744: 4742: 4734: 4733: 4731: 4730: 4729: 4728: 4723: 4718: 4713: 4708: 4703: 4698: 4693: 4688: 4683: 4666: 4665: 4664: 4663: 4653: 4652: 4651: 4639: 4638: 4637: 4632: 4627: 4622: 4617: 4612: 4607: 4602: 4597: 4592: 4575: 4573: 4562: 4544: 4536: 4535: 4532: 4531: 4529: 4528: 4523: 4518: 4517: 4516: 4511: 4506: 4496: 4491: 4485: 4483: 4479: 4478: 4475: 4474: 4472: 4471: 4466: 4465: 4464: 4459: 4449: 4444: 4443: 4442: 4437: 4436: 4435: 4430: 4413: 4411:Arp2/3 complex 4408: 4407: 4406: 4401: 4396: 4391: 4380: 4379: 4378: 4377: 4372: 4367: 4362: 4352: 4351: 4350: 4336: 4325: 4306: 4305: 4304: 4299: 4294: 4289: 4278: 4276: 4272: 4271: 4269: 4268: 4267: 4266: 4261: 4256: 4251: 4246: 4241: 4236: 4231: 4226: 4221: 4216: 4211: 4206: 4196: 4195: 4194: 4189: 4181: 4180: 4179: 4171: 4170: 4169: 4161: 4160: 4159: 4154: 4146: 4145: 4144: 4139: 4131: 4130: 4129: 4121: 4120: 4119: 4114: 4109: 4101: 4100: 4099: 4094: 4086: 4085: 4084: 4079: 4074: 4069: 4064: 4059: 4054: 4049: 4044: 4039: 4034: 4029: 4024: 4019: 4014: 4006: 4005: 4004: 3998: 3993: 3988: 3983: 3978: 3973: 3968: 3959: 3957: 3951: 3950: 3948: 3947: 3942: 3937: 3932: 3927: 3922: 3916: 3914: 3905: 3896: 3889:Microfilaments 3882: 3878: 3877: 3868: 3866: 3865: 3858: 3851: 3843: 3837: 3836: 3815: 3805: 3800: 3786: 3785:External links 3783: 3781: 3780: 3762:(4): 293–296. 3750: 3748: 3745: 3743: 3742: 3715:(3): 421–443. 3699: 3658: 3639:(2): 175–183. 3622: 3592: 3563:(3): 158–172. 3540: 3511:(2): 685–702. 3491: 3461:(2): 558–562. 3441: 3382: 3355: 3334:(2): 142–149. 3311: 3262: 3235:(1): 117–120. 3219: 3170: 3144: 3117:(1): 203–208. 3101: 3052: 3009: 2965: 2922: 2911:(4): 425–432. 2895: 2868:(1): 320–327. 2852: 2837: 2788: 2759:(4): 607–615. 2739: 2724: 2698: 2647: 2626:(4): 383–388. 2606: 2571: 2542:(1): 225–234. 2522: 2473: 2411: 2383: 2340: 2305:Brain Research 2291: 2262:(1): 128–133. 2242: 2199: 2188:(4): 393–400. 2172: 2137: 2093: 2049: 2016:Brain Research 2006: 1979:(1): 147–155. 1960: 1941:(1): 152–154. 1924: 1906: 1888: 1867: 1845: 1843: 1840: 1839: 1838: 1833: 1825: 1822: 1794: 1791: 1774: 1771: 1698:viral envelope 1621:fibrous tissue 1609:Glial scarring 1582:immunostaining 1566:immunostaining 1557: 1556:Disease states 1554: 1540:autoantibodies 1511: 1508: 1483:which are two 1451: 1442:Purkinje cells 1343: 1340: 1269: 1266: 1153: 1152: 1149: 1148: 1143: 1133: 1132: 1126: 1125: 1122: 1121: 1119: 1117: 1110: 1109: 1102: 1095: 1091: 1090: 1087: 1086: 1072: 1071: 1065: 1062: 1061: 1039: 1038: 1032: 1028: 1027: 1024: 1023: 1009: 1008: 1002: 999: 998: 976: 975: 969: 965: 964: 961: 960: 952: 951: 945: 942: 941: 933: 932: 926: 920: 919: 916: 915: 907: 906: 900: 897: 896: 888: 887: 881: 875: 874: 871: 870: 862: 861: 855: 852: 851: 843: 842: 836: 830: 829: 824: 819: 815: 814: 804: 803: 800: 799: 788: 787: 785: 784: 779: 774: 769: 764: 759: 754: 749: 744: 739: 734: 729: 724: 719: 713: 711: 707: 706: 704: 703: 698: 693: 688: 683: 678: 673: 668: 663: 658: 653: 648: 643: 638: 632: 630: 626: 625: 623: 622: 620:kinase binding 617: 612: 607: 602: 597: 591: 589: 585: 584: 574: 573: 570: 569: 566: 565: 557: 556: 545: 539: 538: 535: 534: 526: 525: 522: 521: 519: 518: 514: 510: 506: 502: 498: 494: 490: 489:pontine nuclei 486: 482: 478: 475: 474: 463: 460: 459: 457: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 416: 413: 412: 400: 399: 391: 380: 374: 373: 370:RNA expression 362: 361: 358: 357: 349: 345: 344: 336: 333: 328: 322: 321: 312: 305: 299: 295: 294: 289: 283: 282: 274: 273: 261: 260: 257: 256: 248: 244: 243: 235: 232: 227: 221: 220: 211: 204: 198: 194: 193: 186: 180: 179: 171: 170: 158: 157: 114: 110: 109: 101: 93: 92: 88: 87: 84: 83: 80: 79: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 6198: 6187: 6184: 6182: 6179: 6177: 6174: 6173: 6171: 6158: 6157: 6150: 6142: 6139: 6137: 6134: 6132: 6129: 6127: 6124: 6123: 6122: 6119: 6117: 6114: 6113: 6111: 6107: 6097: 6094: 6092: 6089: 6085: 6082: 6080: 6077: 6076: 6075: 6072: 6070: 6067: 6063: 6060: 6059: 6058: 6055: 6051: 6048: 6046: 6043: 6041: 6038: 6036: 6033: 6031: 6028: 6026: 6023: 6021: 6018: 6017: 6016: 6013: 6012: 6010: 6006: 5998: 5995: 5993: 5990: 5988: 5985: 5983: 5980: 5978: 5975: 5973: 5970: 5968: 5965: 5964: 5963: 5960: 5956: 5953: 5951: 5948: 5946: 5943: 5942: 5941: 5938: 5936: 5933: 5929: 5926: 5925: 5924: 5921: 5920: 5918: 5916: 5912: 5906: 5903: 5901: 5900:Delta catenin 5898: 5896: 5893: 5889: 5886: 5885: 5884: 5881: 5879: 5878:Alpha catenin 5876: 5875: 5873: 5871: 5867: 5855: 5852: 5850: 5847: 5845: 5842: 5841: 5840: 5837: 5833: 5830: 5828: 5825: 5823: 5820: 5818: 5815: 5813: 5810: 5809: 5808: 5805: 5803: 5800: 5796: 5793: 5792: 5791: 5788: 5786: 5783: 5782: 5780: 5776: 5770: 5767: 5765: 5762: 5761: 5759: 5755: 5749: 5746: 5744: 5741: 5739: 5736: 5734: 5731: 5729: 5726: 5724: 5721: 5719: 5716: 5715: 5713: 5711: 5707: 5701: 5698: 5696: 5693: 5691: 5688: 5686: 5683: 5681: 5678: 5676: 5673: 5671: 5668: 5666: 5663: 5661: 5658: 5656: 5653: 5651: 5648: 5646: 5643: 5641: 5638:cytoplasmic: 5637: 5636: 5633: 5630: 5628: 5625: 5623: 5620: 5618: 5615: 5613: 5610: 5608: 5605: 5603: 5600: 5598: 5595: 5593: 5590: 5588: 5585: 5583: 5580: 5578: 5575: 5573: 5570: 5568: 5565: 5563: 5560: 5558: 5555: 5553: 5550: 5548: 5545: 5543: 5539: 5538: 5536: 5534: 5530: 5524: 5521: 5519: 5516: 5514: 5511: 5509: 5506: 5504: 5501: 5499: 5496: 5494: 5491: 5489: 5486: 5484: 5481: 5479: 5476: 5474: 5471: 5469: 5466: 5464: 5461: 5459: 5456: 5454: 5451: 5449: 5446: 5444: 5441: 5439: 5436: 5434: 5431: 5429: 5426: 5424: 5421: 5419: 5416: 5414: 5411: 5409: 5406: 5404: 5401: 5399: 5396: 5394: 5391: 5389: 5386: 5384: 5381: 5379: 5376: 5374: 5371: 5369: 5366: 5364: 5361: 5359: 5356: 5354: 5351: 5349: 5346: 5344: 5341: 5339: 5336: 5334: 5331: 5330: 5328: 5326: 5322: 5316: 5313: 5311: 5308: 5306: 5303: 5301: 5298: 5296: 5293: 5291: 5288: 5286: 5283: 5282: 5280: 5278: 5274: 5268: 5265: 5263: 5260: 5258: 5255: 5253: 5250: 5248: 5245: 5243: 5240: 5238: 5235: 5233: 5230: 5228: 5225: 5223: 5220: 5218: 5215: 5213: 5210: 5208: 5205: 5203: 5200: 5198: 5195: 5193: 5190: 5188: 5185: 5183: 5180: 5178: 5175: 5173: 5170: 5168: 5165: 5163: 5160: 5158: 5155: 5153: 5150: 5148: 5145: 5143: 5140: 5138: 5135: 5134: 5132: 5130: 5126: 5123: 5121: 5116: 5112: 5102: 5099: 5097: 5094: 5092: 5088: 5085: 5084: 5082: 5078: 5072: 5069: 5067: 5064: 5060: 5057: 5055: 5052: 5050: 5047: 5046: 5045: 5044:Neurofilament 5042: 5040: 5037: 5035: 5032: 5031: 5029: 5025: 5019: 5016: 5014: 5011: 5009: 5006: 5004: 5001: 5000: 4998: 4994: 4984: 4981: 4980: 4978: 4974: 4966: 4963: 4961: 4958: 4956: 4953: 4951: 4948: 4946: 4943: 4941: 4938: 4936: 4933: 4931: 4928: 4926: 4923: 4921: 4918: 4917: 4916: 4915: 4914:chromosome 12 4911: 4910: 4905: 4902: 4900: 4897: 4895: 4892: 4890: 4887: 4885: 4882: 4880: 4877: 4875: 4872: 4870: 4867: 4866: 4865: 4864: 4863:chromosome 17 4860: 4859: 4857: 4853: 4845: 4842: 4840: 4837: 4835: 4832: 4830: 4827: 4825: 4822: 4820: 4817: 4816: 4815: 4814: 4813:chromosome 12 4810: 4806: 4805: 4800: 4797: 4795: 4792: 4790: 4787: 4785: 4782: 4780: 4777: 4775: 4772: 4770: 4767: 4765: 4762: 4760: 4757: 4756: 4755: 4754: 4753:chromosome 17 4750: 4746: 4745: 4743: 4739: 4738:Hair keratins 4735: 4727: 4724: 4722: 4719: 4717: 4714: 4712: 4709: 4707: 4704: 4702: 4699: 4697: 4694: 4692: 4689: 4687: 4684: 4682: 4679: 4678: 4677: 4676: 4675:chromosome 12 4672: 4668: 4667: 4662: 4659: 4658: 4657: 4654: 4650: 4647: 4646: 4645: 4644: 4643:chromosome 12 4640: 4636: 4633: 4631: 4628: 4626: 4623: 4621: 4618: 4616: 4613: 4611: 4608: 4606: 4603: 4601: 4598: 4596: 4593: 4591: 4588: 4587: 4586: 4585: 4584:chromosome 17 4581: 4577: 4576: 4574: 4570: 4566: 4563: 4560: 4555: 4548: 4545: 4543: 4540:Intermediate 4537: 4527: 4524: 4522: 4519: 4515: 4512: 4510: 4507: 4505: 4502: 4501: 4500: 4497: 4495: 4492: 4490: 4487: 4486: 4484: 4480: 4470: 4467: 4463: 4460: 4458: 4455: 4454: 4453: 4450: 4448: 4445: 4441: 4438: 4434: 4431: 4429: 4426: 4425: 4424: 4421: 4420: 4419: 4418: 4414: 4412: 4409: 4405: 4402: 4400: 4397: 4395: 4392: 4390: 4387: 4386: 4385: 4382: 4381: 4376: 4373: 4371: 4368: 4366: 4363: 4361: 4358: 4357: 4356: 4353: 4349: 4346: 4343: 4340: 4337: 4335: 4332: 4329: 4326: 4324: 4321: 4318: 4315: 4312: 4311: 4310: 4307: 4303: 4300: 4298: 4295: 4293: 4290: 4288: 4285: 4284: 4283: 4280: 4279: 4277: 4273: 4265: 4262: 4260: 4257: 4255: 4252: 4250: 4247: 4245: 4242: 4240: 4237: 4235: 4232: 4230: 4227: 4225: 4222: 4220: 4217: 4215: 4212: 4210: 4207: 4205: 4202: 4201: 4200: 4197: 4193: 4190: 4188: 4185: 4184: 4182: 4178: 4175: 4174: 4172: 4168: 4165: 4164: 4162: 4158: 4155: 4153: 4150: 4149: 4147: 4143: 4140: 4138: 4135: 4134: 4132: 4128: 4125: 4124: 4122: 4118: 4115: 4113: 4110: 4108: 4105: 4104: 4102: 4098: 4095: 4093: 4090: 4089: 4087: 4083: 4080: 4078: 4075: 4073: 4070: 4068: 4065: 4063: 4060: 4058: 4055: 4053: 4050: 4048: 4045: 4043: 4040: 4038: 4035: 4033: 4030: 4028: 4025: 4023: 4020: 4018: 4015: 4013: 4010: 4009: 4007: 4002: 3999: 3997: 3994: 3992: 3989: 3987: 3984: 3982: 3979: 3977: 3974: 3972: 3969: 3967: 3964: 3963: 3961: 3960: 3958: 3956: 3952: 3946: 3943: 3941: 3938: 3936: 3933: 3931: 3928: 3926: 3923: 3921: 3918: 3917: 3915: 3913: 3909: 3906: 3904: 3900: 3897: 3895: 3890: 3886: 3883: 3879: 3875: 3871: 3864: 3859: 3857: 3852: 3850: 3845: 3844: 3841: 3834: 3830: 3829: 3824: 3820: 3816: 3813: 3809: 3806: 3804: 3801: 3799: 3795: 3792: 3789: 3788: 3784: 3777: 3773: 3769: 3765: 3761: 3757: 3752: 3751: 3746: 3738: 3734: 3730: 3726: 3722: 3718: 3714: 3710: 3703: 3700: 3695: 3691: 3686: 3681: 3677: 3673: 3669: 3662: 3659: 3654: 3650: 3646: 3642: 3638: 3634: 3626: 3623: 3610: 3606: 3602: 3596: 3593: 3588: 3584: 3580: 3576: 3571: 3566: 3562: 3558: 3554: 3547: 3545: 3541: 3536: 3532: 3527: 3522: 3518: 3514: 3510: 3506: 3502: 3495: 3492: 3480: 3476: 3472: 3468: 3464: 3460: 3456: 3452: 3445: 3442: 3437: 3433: 3428: 3423: 3418: 3413: 3409: 3405: 3401: 3397: 3393: 3386: 3383: 3378: 3374: 3370: 3366: 3359: 3356: 3351: 3347: 3342: 3337: 3333: 3329: 3325: 3318: 3316: 3312: 3307: 3303: 3298: 3293: 3289: 3285: 3281: 3277: 3273: 3266: 3263: 3258: 3254: 3250: 3246: 3242: 3241:10.1038/83679 3238: 3234: 3230: 3223: 3220: 3215: 3211: 3206: 3201: 3197: 3193: 3189: 3185: 3181: 3174: 3171: 3159: 3155: 3148: 3145: 3140: 3136: 3132: 3128: 3124: 3120: 3116: 3112: 3105: 3102: 3097: 3093: 3088: 3083: 3079: 3075: 3071: 3067: 3063: 3056: 3053: 3048: 3044: 3040: 3036: 3032: 3028: 3024: 3020: 3013: 3010: 3005: 3001: 2997: 2993: 2989: 2985: 2981: 2977: 2969: 2966: 2961: 2957: 2953: 2949: 2945: 2941: 2937: 2933: 2926: 2923: 2918: 2914: 2910: 2906: 2899: 2896: 2891: 2887: 2883: 2879: 2875: 2871: 2867: 2863: 2856: 2853: 2850: 2846: 2841: 2838: 2833: 2829: 2824: 2819: 2815: 2811: 2807: 2803: 2799: 2792: 2789: 2784: 2780: 2776: 2772: 2767: 2762: 2758: 2754: 2750: 2743: 2740: 2735: 2731: 2727: 2721: 2717: 2713: 2709: 2702: 2699: 2694: 2690: 2685: 2680: 2675: 2670: 2666: 2662: 2658: 2651: 2648: 2643: 2639: 2634: 2629: 2625: 2621: 2617: 2610: 2607: 2602: 2598: 2594: 2590: 2586: 2582: 2575: 2572: 2567: 2563: 2558: 2553: 2549: 2545: 2541: 2537: 2533: 2526: 2523: 2518: 2514: 2509: 2504: 2500: 2496: 2492: 2488: 2484: 2477: 2474: 2469: 2465: 2460: 2455: 2450: 2445: 2441: 2437: 2433: 2429: 2425: 2418: 2416: 2412: 2407: 2403: 2399: 2395: 2387: 2384: 2379: 2375: 2371: 2367: 2363: 2359: 2355: 2351: 2344: 2341: 2336: 2332: 2327: 2322: 2318: 2314: 2310: 2306: 2302: 2295: 2292: 2287: 2283: 2278: 2273: 2269: 2265: 2261: 2257: 2253: 2246: 2243: 2238: 2234: 2230: 2226: 2222: 2218: 2214: 2210: 2203: 2200: 2195: 2191: 2187: 2183: 2176: 2173: 2168: 2164: 2160: 2156: 2152: 2148: 2141: 2138: 2133: 2129: 2125: 2121: 2117: 2113: 2109: 2105: 2097: 2094: 2089: 2085: 2081: 2077: 2073: 2069: 2065: 2061: 2053: 2050: 2045: 2041: 2037: 2033: 2029: 2025: 2021: 2017: 2010: 2007: 2002: 1998: 1994: 1990: 1986: 1982: 1978: 1974: 1967: 1965: 1961: 1956: 1952: 1948: 1944: 1940: 1936: 1928: 1925: 1920: 1916: 1910: 1907: 1902: 1898: 1892: 1889: 1885: 1881: 1876: 1874: 1872: 1868: 1864: 1860: 1855: 1853: 1851: 1847: 1841: 1837: 1834: 1831: 1828: 1827: 1823: 1821: 1819: 1816: 1812: 1808: 1804: 1800: 1792: 1790: 1788: 1784: 1780: 1772: 1770: 1768: 1764: 1760: 1756: 1752: 1748: 1744: 1739: 1737: 1733: 1729: 1728:schizophrenia 1725: 1721: 1717: 1713: 1709: 1705: 1702: 1699: 1696: 1692: 1688: 1685:infection or 1684: 1680: 1675: 1673: 1669: 1665: 1661: 1660:coding region 1657: 1653: 1649: 1645: 1641: 1637: 1633: 1628: 1626: 1625:up-regulation 1622: 1618: 1614: 1610: 1606: 1599: 1595: 1591: 1587: 1583: 1578: 1571: 1567: 1562: 1555: 1553: 1551: 1547: 1543: 1541: 1537: 1533: 1529: 1525: 1521: 1517: 1509: 1507: 1505: 1501: 1497: 1492: 1490: 1486: 1482: 1478: 1474: 1470: 1466: 1462: 1458: 1454: 1447: 1443: 1439: 1438:antisense RNA 1435: 1431: 1427: 1423: 1418: 1416: 1412: 1408: 1404: 1400: 1399:knockout mice 1396: 1392: 1388: 1384: 1381: 1376: 1371: 1369: 1365: 1361: 1357: 1353: 1349: 1341: 1339: 1337: 1333: 1328: 1327: 1322: 1318: 1313: 1311: 1307: 1303: 1299: 1295: 1291: 1287: 1283: 1279: 1275: 1267: 1265: 1263: 1262:chromosome 17 1259: 1255: 1252: 1248: 1244: 1240: 1236: 1232: 1227: 1225: 1221: 1217: 1213: 1209: 1208:keratinocytes 1205: 1201: 1198: 1194: 1190: 1186: 1182: 1178: 1174: 1171: 1167: 1163: 1159: 1147: 1142: 1138: 1134: 1131: 1127: 1120: 1118: 1115: 1111: 1107: 1103: 1100: 1096: 1092: 1085: 1083: 1079: 1073: 1069: 1066: 1060: 1058: 1054: 1050: 1046: 1040: 1036: 1033: 1029: 1022: 1020: 1016: 1010: 1006: 1003: 997: 995: 991: 987: 983: 977: 973: 970: 968:RefSeq (mRNA) 966: 959: 958: 953: 949: 946: 940: 939: 934: 930: 927: 925: 921: 914: 913: 908: 904: 901: 895: 894: 889: 885: 882: 880: 876: 869: 868: 863: 859: 856: 850: 849: 844: 840: 837: 835: 831: 828: 825: 823: 820: 816: 813: 809: 805: 798: 794: 789: 783: 780: 778: 775: 773: 770: 768: 765: 763: 760: 758: 755: 753: 750: 748: 745: 743: 740: 738: 735: 733: 730: 728: 725: 723: 720: 718: 715: 714: 712: 709: 708: 702: 699: 697: 694: 692: 689: 687: 684: 682: 679: 677: 674: 672: 671:myelin sheath 669: 667: 664: 662: 659: 657: 654: 652: 649: 647: 644: 642: 639: 637: 634: 633: 631: 628: 627: 621: 618: 616: 613: 611: 608: 606: 603: 601: 598: 596: 593: 592: 590: 587: 586: 583: 582:Gene ontology 579: 575: 563: 558: 554: 549: 546: 544: 540: 532: 527: 516: 512: 508: 504: 500: 496: 492: 488: 484: 480: 479: 476: 472: 467: 464: 454: 450: 446: 442: 438: 434: 430: 426: 422: 418: 417: 414: 410: 405: 402: 401: 398: 396: 392: 390: 389: 385: 384: 381: 379: 375: 371: 367: 363: 355: 350: 346: 342: 337: 327: 323: 316: 309: 303: 296: 288: 284: 280: 275: 271: 266: 262: 254: 249: 245: 241: 236: 226: 222: 215: 208: 202: 195: 191: 185: 181: 177: 172: 168: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 111: 106: 99: 94: 89: 78: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 6153: 5928:Dystroglycan 5883:Beta catenin 5115:Microtubules 5007: 4983:Beta-keratin 4912: 4861: 4807: 4747: 4669: 4655: 4641: 4578: 4415: 4282:Tropomodulin 3874:cytoskeleton 3826: 3759: 3755: 3712: 3708: 3702: 3675: 3671: 3661: 3636: 3632: 3625: 3613:. Retrieved 3609:the original 3595: 3560: 3556: 3508: 3504: 3494: 3483:. Retrieved 3458: 3454: 3444: 3399: 3395: 3385: 3368: 3364: 3358: 3331: 3327: 3279: 3275: 3265: 3232: 3228: 3222: 3187: 3183: 3173: 3162:. Retrieved 3147: 3114: 3110: 3104: 3072:(1): 67–94. 3069: 3065: 3055: 3022: 3018: 3012: 2979: 2975: 2968: 2935: 2931: 2925: 2908: 2904: 2898: 2865: 2861: 2855: 2840: 2805: 2801: 2791: 2756: 2752: 2742: 2707: 2701: 2664: 2660: 2650: 2623: 2619: 2609: 2584: 2580: 2574: 2539: 2535: 2525: 2490: 2486: 2476: 2431: 2427: 2397: 2393: 2386: 2353: 2349: 2343: 2308: 2304: 2294: 2259: 2255: 2245: 2215:(1): 22–26. 2212: 2208: 2202: 2185: 2181: 2175: 2153:(1): 39–49. 2150: 2146: 2140: 2107: 2103: 2096: 2066:(1): 53–61. 2063: 2059: 2052: 2022:(1): 13–21. 2019: 2015: 2009: 1976: 1972: 1938: 1934: 1927: 1918: 1909: 1900: 1891: 1811:morphologies 1796: 1776: 1773:Interactions 1740: 1720:pseudorabies 1701:glycoprotein 1676: 1664:cytoskeleton 1629: 1602: 1544: 1526:, the brain 1513: 1493: 1475:residues by 1419: 1407:white matter 1372: 1345: 1324: 1314: 1298:heterodimers 1271: 1247:cytoskeleton 1228: 1216:chondrocytes 1204:Leydig cells 1169: 1161: 1157: 1156: 1078:NP_001124492 1075: 1057:NP_001350775 1049:NP_001229305 1045:NP_001124491 1042: 1015:NM_001131020 1012: 994:NM_001363846 990:NM_001242376 986:NM_001131019 979: 955: 936: 910: 891: 865: 846: 826: 821: 701:cytoskeleton 451:hypothalamus 393: 386: 352:102,791,738 339:102,778,162 113:External IDs 72: 6074:Plakophilin 6025:Desmoplakin 5785:Tau protein 4559:Cytokeratin 4355:Tropomyosin 3903:Myofilament 3615:11 December 3371:: 253–257. 2587:: 345–382. 2311:: 103–115. 1654:, known as 1648:cytoplasmic 1605:glial cells 1532:spinal cord 1496:glial scars 1489:cytoplasmic 1467:at various 1403:myelination 1364:hippocampus 1300:; GFAP can 1284:, with the 1258:cell marker 1200:fibroblasts 1197:peritubular 481:optic nerve 443:optic nerve 251:44,916,937 238:44,903,159 91:Identifiers 6170:Categories 6154:See also: 6126:Crescentin 6045:Periplakin 6035:Envoplakin 5923:Dystrophin 5540:axonemal: 5034:Internexin 5013:Peripherin 3485:2019-06-26 3164:2007-03-05 3025:: 101900. 2982:: 101924. 1886:, May 2017 1865:, May 2017 1842:References 1836:GFAP stain 1803:astrocytes 1736:depression 1640:spasticity 1617:astrocytes 1530:, and the 1528:parenchyma 1516:antibodies 1463:dependent 1461:calmodulin 1302:polymerize 1294:homodimers 1290:C-terminal 1286:N-terminal 1243:peripherin 1231:epithelial 1212:osteocytes 1185:astrocytes 439:C1 segment 397:(ortholog) 134:HomoloGene 5743:Centrin 3 5738:Centrin 2 5733:Centrin 1 5071:Syncoilin 4976:Not alpha 4542:filaments 4494:Fibrillin 3587:246492708 3047:209498996 3004:210166834 2667:(1): 52. 1818:pathology 1747:biomarker 1672:apoptosis 1668:caspase 3 1627:of GFAP. 1473:threonine 1422:astrocyte 1332:arginines 1317:tetramers 1268:Structure 1251:astrocyte 1226:in rats. 1193:glomeruli 1082:NP_034407 1053:NP_002046 1019:NM_010277 982:NM_002055 812:Orthologs 676:cell body 636:cytoplasm 142:GeneCards 6181:Proteins 6109:Nonhuman 6069:Vinculin 6030:Dystonin 5962:Spectrin 5935:Utrophin 5915:Membrane 5870:Catenins 5802:Stathmin 5790:Dynactin 5670:DYNC2LI1 5665:DYNC1LI2 5660:DYNC1LI1 5325:Kinesins 5129:Tubulins 5018:Vimentin 4550:Type 1/2 4452:Profilin 4447:Gelsolin 4309:Troponin 3870:Proteins 3794:Archived 3776:16996408 3737:41192525 3729:21219963 3694:12058025 3653:12169273 3579:35115728 3479:Archived 3455:Virology 3350:10822341 3306:21756903 3257:10159452 3249:11138011 3214:17065456 3158:Archived 3139:25610288 3096:13688845 3039:31881522 2996:31927153 2890:28248825 2847:(OMIM): 2783:14714870 2693:35765081 2642:24005729 2370:11059815 2335:17555726 2237:34069861 2167:11993850 2088:31851422 2044:38131934 2001:10224197 1935:Genomics 1882:– 1861:– 1824:See also 1799:isoforms 1793:Isoforms 1779:interact 1679:isoforms 1644:seizures 1636:dementia 1586:vimentin 1524:meninges 1436:, using 1434:In vitro 1387:G2 phase 1336:aromatic 1326:in vitro 1306:keratins 1235:vimentin 1220:pancreas 1210:, human 1130:Wikidata 791:Sources: 661:membrane 646:lysosome 513:habenula 230:17q21.31 6096:PLEKHA7 6050:Plectin 6015:Plakins 5940:Ankyrin 5839:Dynamin 5769:Spastin 5764:Katanin 5728:CAMSAP3 5723:CAMSAP2 5718:CAMSAP1 5690:DYNLRB2 5685:DYNLRB1 5655:DYNC1I2 5650:DYNC1I1 5645:DYNC2H1 5640:DYNC1H1 5533:Dyneins 5257:TUBGCP6 5252:TUBGCP5 5247:TUBGCP4 5242:TUBGCP3 5237:TUBGCP2 5066:Synemin 4809:type II 4671:type II 4554:Keratin 4499:Filamin 4440:Destrin 4423:Cofilin 4384:Actinin 3955:Myosins 3872:of the 3833:PDBe-KB 3823:UniProt 3535:8381171 3526:6576625 3475:7975257 3436:8381971 3404:Bibcode 3377:8974344 3297:4308095 3205:6674663 3131:3682026 3087:2225064 2960:1411700 2952:4038838 2917:3548695 2882:1727439 2832:1999469 2823:2288905 2775:8893019 2734:2165732 2684:9241296 2601:7979242 2566:2745549 2557:2115473 2517:1710225 2508:2289006 2468:2740350 2436:Bibcode 2406:1847665 2378:9221868 2326:3179863 2286:9771417 2277:1727174 2229:2654484 2194:6205529 2132:3766335 2124:1720132 2080:9691426 2036:6998542 1955:9693047 1884:Ensembl 1863:Ensembl 1712:chronic 1536:cancers 1485:kinases 1457:calcium 1455:and/or 1391:kinases 1375:mitosis 1334:and an 1278:protein 1166:protein 1164:) is a 924:UniProt 879:Ensembl 818:Species 797:QuickGO 641:cytosol 372:pattern 98:Aliases 5997:SPTBN5 5992:SPTBN4 5987:SPTBN2 5982:SPTBN1 5972:SPTAN1 5807:Tektin 5700:DYNLT3 5695:DYNLT1 5680:DYNLL2 5675:DYNLL1 5622:DNALI1 5607:DNAH17 5602:DNAH14 5597:DNAH13 5592:DNAH12 5587:DNAH11 5582:DNAH10 5503:KIF26B 5498:KIF26A 5473:KIF21B 5468:KIF21A 5463:KIF20B 5458:KIF20A 5448:KIF18B 5443:KIF18A 5433:KIF16B 5418:KIF13B 5413:KIF13A 5212:TUBB4Q 5197:TUBB2C 5192:TUBB2B 5187:TUBB2A 5167:TUBA4A 5162:TUBA3E 5157:TUBA3D 5152:TUBA3C 5147:TUBA1C 5142:TUBA1B 5137:TUBA1A 5080:Type 5 5039:Nestin 5027:Type 4 5003:Desmin 4996:Type 3 4749:type I 4580:type I 4526:TRIOBP 4192:MYO18B 4187:MYO18A 4183:XVIII 4177:MYO15A 3912:Actins 3828:P14136 3814:(MeSH) 3774:  3735:  3727:  3692:  3651:  3585:  3577:  3533:  3523:  3473:  3434:  3424:  3375:  3348:  3304:  3294:  3255:  3247:  3212:  3202:  3137:  3129:  3094:  3084:  3045:  3037:  3002:  2994:  2958:  2950:  2915:  2888:  2880:  2830:  2820:  2781:  2773:  2753:Neuron 2732:  2722:  2691:  2681:  2640:  2599:  2564:  2554:  2515:  2505:  2466:  2459:297581 2456:  2404:  2376:  2368:  2333:  2323:  2284:  2274:  2235:  2227:  2192:  2165:  2130:  2122:  2086:  2078:  2042:  2034:  1999:  1993:624958 1991:  1953:  1718:, and 1693:. The 1469:serine 1426:neuron 1383:kinase 1239:desmin 1116:search 1114:PubMed 957:P03995 938:P14136 834:Entrez 543:BioGPS 122:137780 6057:Talin 6040:MACF1 6008:Other 5967:SPTA1 5832:TEKT5 5827:TEKT4 5822:TEKT3 5817:TEKT2 5812:TEKT1 5795:DCTN1 5778:Other 5632:DNAL4 5627:DNAL1 5617:DNAI2 5612:DNAI1 5577:DNAH9 5572:DNAH8 5567:DNAH7 5562:DNAH6 5557:DNAH5 5552:DNAH3 5547:DNAH2 5542:DNAH1 5523:KIFC3 5518:KIFC2 5513:KIFC1 5508:KIF27 5493:KIF25 5488:KIF24 5483:KIF23 5478:KIF22 5453:KIF19 5438:KIF17 5428:KIF15 5423:KIF14 5408:KIF12 5403:KIF11 5383:KIF5C 5378:KIF5B 5373:KIF5A 5368:KIF4B 5363:KIF4A 5358:KIF3C 5353:KIF3B 5348:KIF2C 5343:KIF2A 5338:KIF1B 5333:KIF1A 5305:MAP1B 5300:MAP1A 5267:TUBE1 5262:TUBD1 5232:TUBG2 5227:TUBG1 5222:TUBB8 5217:TUBB6 5207:TUBB4 5202:TUBB3 5182:TUBB1 5172:TUBA8 4521:Espin 4482:Other 4469:Titin 4275:Other 4264:MYLL1 4259:MYLK2 4249:MYLIP 4234:MYL6B 4167:MYO10 4157:MYO9B 4152:MYO9A 4142:MYO7B 4137:MYO7A 4117:MYO5C 4112:MYO5B 4107:MYO5A 4097:MYO3B 4092:MYO3A 4082:MYH16 4077:MYH15 4072:MYH14 4067:MYH13 4062:MYH11 4057:MYH10 4042:MYH7B 4001:MYO1H 3996:MYO1G 3991:MYO1F 3986:MYO1E 3981:MYO1D 3976:MYO1C 3971:MYO1B 3966:MYO1A 3881:Human 3733:S2CID 3583:S2CID 3427:45910 3253:S2CID 3135:S2CID 3043:S2CID 3000:S2CID 2956:S2CID 2886:S2CID 2779:S2CID 2374:S2CID 2233:S2CID 2128:S2CID 2084:S2CID 2040:S2CID 1997:S2CID 1787:PSEN1 1781:with 1704:gp120 1695:HIV-1 1683:acute 1580:GFAP 1564:GFAP 1504:brain 1282:dimer 1224:liver 867:14580 827:Mouse 822:Human 793:Amigo 395:Mouse 388:Human 335:Start 270:Mouse 234:Start 167:Human 130:95697 6141:ParM 6136:MreB 6131:FtsZ 6091:ACF7 6084:PKP2 6079:PKP1 6062:TLN1 5977:SPTB 5955:ANK3 5950:ANK2 5945:ANK1 5854:DNM3 5849:DNM2 5844:DNM1 5748:PCM1 5398:KIF9 5393:KIF7 5388:KIF6 5315:MAP4 5310:MAP2 5277:MAPs 5177:TUBB 5120:MAPs 5118:and 5059:NEFH 5054:NEFM 5049:NEFL 5008:GFAP 4656:none 4514:FLNC 4509:FLNB 4504:FLNA 4254:MYLK 4244:MYL9 4239:MYL7 4229:MYL6 4224:MYL5 4219:MYL4 4214:MYL3 4209:MYL2 4204:MYL1 4133:VII 4127:MYO6 4088:III 4052:MYH9 4047:MYH8 4037:MYH7 4032:MYH6 4027:MYH4 4022:MYH3 4017:MYH2 4012:MYH1 3894:ABPs 3892:and 3821:for 3772:PMID 3725:PMID 3690:PMID 3649:PMID 3617:2010 3575:PMID 3531:PMID 3471:PMID 3432:PMID 3373:PMID 3346:PMID 3302:PMID 3245:PMID 3210:PMID 3127:PMID 3092:PMID 3035:PMID 2992:PMID 2948:PMID 2913:PMID 2878:PMID 2828:PMID 2771:PMID 2730:PMID 2720:ISBN 2689:PMID 2638:PMID 2597:PMID 2562:PMID 2513:PMID 2464:PMID 2402:PMID 2366:PMID 2331:PMID 2309:1158 2282:PMID 2225:PMID 2190:PMID 2163:PMID 2120:PMID 2076:PMID 2032:PMID 1989:PMID 1951:PMID 1785:and 1783:MEN1 1761:and 1753:and 1734:and 1594:DAPI 1502:and 1479:and 1450:MgCl 1380:cdc2 1362:and 1296:and 1288:and 1241:and 1222:and 1214:and 1195:and 1187:and 1173:gene 1170:GFAP 1162:GFAP 848:2670 378:Bgee 326:Band 287:Chr. 225:Band 184:Chr. 146:GFAP 138:1554 118:OMIM 105:GFAP 75:6A9P 56:RCSB 53:PDBe 22:GFAP 5905:GAN 5888:APC 5295:EB3 5290:EB2 5285:EB1 5091:A/C 4774:33B 4769:33A 4173:XV 4148:IX 4123:VI 4008:II 3819:PDB 3764:doi 3717:doi 3680:doi 3676:277 3641:doi 3637:278 3565:doi 3521:PMC 3513:doi 3463:doi 3459:205 3422:PMC 3412:doi 3336:doi 3292:PMC 3284:doi 3280:317 3237:doi 3200:PMC 3192:doi 3119:doi 3082:PMC 3074:doi 3027:doi 2984:doi 2940:doi 2870:doi 2818:PMC 2810:doi 2806:112 2761:doi 2712:doi 2679:PMC 2669:doi 2628:doi 2589:doi 2552:PMC 2544:doi 2540:109 2503:PMC 2495:doi 2491:113 2454:PMC 2444:doi 2358:doi 2321:PMC 2313:doi 2272:PMC 2264:doi 2256:Gut 2217:doi 2155:doi 2151:104 2112:doi 2068:doi 2024:doi 2020:200 1981:doi 1943:doi 1743:CNS 1500:eye 1481:PKA 1477:PKC 1471:or 1415:CNS 1352:CNS 1274:DNA 348:End 247:End 150:OMA 126:MGI 46:PDB 6172:: 5101:B2 5096:B1 5089:: 4965:80 4960:79 4955:78 4950:77 4945:76 4940:75 4935:74 4930:73 4925:72 4920:71 4904:40 4899:39 4894:28 4889:27 4884:26 4879:25 4874:24 4869:23 4844:86 4839:85 4834:84 4829:83 4824:82 4819:81 4799:38 4794:37 4789:36 4784:35 4779:34 4764:32 4759:31 4716:6C 4711:6B 4706:6A 4686:2A 4661:21 4649:18 4635:20 4630:19 4625:17 4620:16 4615:15 4610:14 4605:13 4600:12 4595:10 4199:LC 4163:X 4103:V 3962:I 3945:G2 3940:G1 3935:C1 3925:A2 3920:A1 3825:: 3770:. 3760:35 3758:. 3731:. 3723:. 3713:93 3711:. 3688:. 3674:. 3670:. 3647:. 3635:. 3603:. 3581:. 3573:. 3561:18 3559:. 3555:. 3543:^ 3529:. 3519:. 3509:13 3507:. 3503:. 3477:. 3469:. 3457:. 3453:. 3430:. 3420:. 3410:. 3400:90 3398:. 3394:. 3367:. 3344:. 3330:. 3326:. 3314:^ 3300:. 3290:. 3278:. 3274:. 3251:. 3243:. 3233:27 3231:. 3208:. 3198:. 3188:26 3186:. 3182:. 3133:. 3125:. 3115:18 3113:. 3090:. 3080:. 3070:10 3068:. 3064:. 3041:. 3033:. 3023:39 3021:. 2998:. 2990:. 2980:39 2978:. 2954:. 2946:. 2936:65 2934:. 2909:30 2907:. 2884:. 2876:. 2866:58 2864:. 2826:. 2816:. 2804:. 2800:. 2777:. 2769:. 2757:17 2755:. 2751:. 2728:. 2718:. 2687:. 2677:. 2665:15 2663:. 2659:. 2636:. 2624:61 2622:. 2618:. 2595:. 2585:63 2583:. 2560:. 2550:. 2538:. 2534:. 2511:. 2501:. 2489:. 2485:. 2462:. 2452:. 2442:. 2432:86 2430:. 2426:. 2414:^ 2398:51 2396:. 2372:. 2364:. 2354:25 2352:. 2329:. 2319:. 2307:. 2303:. 2280:. 2270:. 2260:43 2258:. 2254:. 2231:. 2223:. 2213:41 2211:. 2186:28 2184:. 2161:. 2149:. 2126:. 2118:. 2108:35 2106:. 2082:. 2074:. 2064:90 2062:. 2038:. 2030:. 2018:. 1995:. 1987:. 1977:35 1975:. 1963:^ 1949:. 1939:51 1937:. 1917:. 1899:. 1870:^ 1849:^ 1820:. 1815:AD 1789:. 1738:. 1730:, 1726:, 1542:. 1506:. 1432:. 1417:. 1405:, 1370:. 1358:, 1264:. 1237:, 795:/ 354:bp 341:bp 253:bp 240:bp 148:; 144:: 140:; 136:: 132:; 128:: 124:; 120:: 4811:/ 4751:/ 4726:8 4721:7 4701:5 4696:4 4691:3 4681:1 4673:/ 4590:9 4582:/ 4561:) 4556:, 4552:( 4462:2 4457:1 4433:2 4428:1 4404:4 4399:3 4394:2 4389:1 4375:4 4370:3 4365:2 4360:1 4348:3 4345:2 4342:1 4339:I 4334:2 4331:1 4328:C 4323:3 4320:2 4317:1 4314:T 4302:4 4297:3 4292:2 4287:1 4003:) 3930:B 3862:e 3855:t 3848:v 3835:. 3778:. 3766:: 3739:. 3719:: 3696:. 3682:: 3655:. 3643:: 3619:. 3589:. 3567:: 3537:. 3515:: 3488:. 3465:: 3438:. 3414:: 3406:: 3379:. 3369:2 3352:. 3338:: 3332:5 3308:. 3286:: 3259:. 3239:: 3216:. 3194:: 3167:. 3141:. 3121:: 3098:. 3076:: 3049:. 3029:: 3006:. 2986:: 2962:. 2942:: 2919:. 2892:. 2872:: 2834:. 2812:: 2785:. 2763:: 2736:. 2714:: 2695:. 2671:: 2644:. 2630:: 2603:. 2591:: 2568:. 2546:: 2519:. 2497:: 2470:. 2446:: 2438:: 2408:. 2380:. 2360:: 2337:. 2315:: 2288:. 2266:: 2239:. 2219:: 2196:. 2169:. 2157:: 2134:. 2114:: 2090:. 2070:: 2046:. 2026:: 2003:. 1983:: 1957:. 1945:: 1921:. 1903:. 1572:) 1459:/ 1452:2 1424:- 1160:( 272:) 169:) 152::

Index


PDB
PDBe
RCSB
6A9P
Aliases
GFAP
OMIM
137780
MGI
95697
HomoloGene
1554
GeneCards
GFAP
OMA
GFAP - orthologs
Human
Chromosome 17 (human)
Chr.
Chromosome 17 (human)
Chromosome 17 (human)
Genomic location for GFAP
Genomic location for GFAP
Band
bp
bp
Mouse
Chromosome 11 (mouse)
Chr.

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.