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Domestication syndrome

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218:, and domestic fowl show a similar reduction to their wild cousins. In a famous Russian farm fox experiment, foxes selectively bred for reduced aggression appeared to show other traits associated with domestication syndrome. This prompted the claim that domestication syndrome was caused by selection for tameness. The foxes were not selectively bred for smaller craniums and teeth, floppy ears, or skills at using human gestures, but these traits were demonstrated in the friendly foxes. Natural selection favors those that are the most successful at reproducing, not the most aggressive. Selection against aggression made possible the ability to cooperate and communicate among foxes, dogs and bonobos. The more docile animals have been found to have less testosterone than their more aggressive counterparts, and testosterone controls aggression and brain size. The further away a dog breed is genetically from wolves, the larger the relative brain size is. 134:
in neural crest related genes only reveals change in neural crest-derived features. In effect, it is not evidence of linked trait changes in different species due to pleiotropic neural crest mechanisms as claimed by the neural crest cell hypothesis. For example, all of the craniofacial skeleton is derived from the neural crest, so any animal population that experiences evolutionary change in craniofacial features will show changes in genes associated with the neural crest. The number and importance of neural crest cell features in all vertebrates means change in these features is almost inevitable under the major selective regime shifts experienced by animals making the wild to domestic transition.
31: 210:, are a close genetic cousin to humans, but unlike the chimpanzees, bonobos are not aggressive and do not participate in lethal inter-group aggression or kill within their own group. The most distinctive features of a bonobo are its cranium, which is 15% smaller than a chimpanzee's, and its less aggressive and more playful behavior. These, and other, features led to the proposal that bonobos are a 'self-domesticated' ape. In other examples, the 73:
shared selective regime changes following transition from wild to domestic environments are a more likely cause of any convergent traits. In addition, the sheer number, diversity, and phenotypic importance of neural crest cell-derived vertebrate features means that changes in genes associated with them are almost inevitable in response to any significant selective change.  
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these traits include tameness, docility, floppy ears, altered tails, novel coat colors and patterns, reduced brain size, reduced body mass and smaller teeth. Other traits include changes in craniofacial morphology, alterations to the endocrine system, and changes to the female estrous cycles including the ability to breed all year-round.
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similarly shared trait changes across different species--in effect, a series of partial trait convergences. They proposed four primary selective pathways that are commonly altered by the shift to a domestic selective context, and would often lead to similar shifts in different populations. These pathways are:
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under selection. But, the observation of changed neural crest cell genes between wild and domestic populations need only reveal changes to features derived from neural crest, it does not support the claim of a common underlying genetic architecture that causes all of the domestication syndrome traits
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cell behaviour may be modified by domestication, which then leads to those traits that are common across many domesticated animal species. This hypothesis has claimed support from many gene-based studies; e.g., However, recent publications have disputed this support; pointing out that observed change
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In 2018, a study identified 429 genes that differed between modern dogs and modern wolves. As the differences in these genes could also be found in ancient dog fossils, these were regarded as being the result of the initial domestication and not from recent breed formation. These genes are linked to
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in 1868 identified various behavioral, morphological, and physiological traits that are shared by domestic animals, but not by their wild ancestors. These shared traits became known as "the domestication syndrome", a term originally used to describe common changes in domesticated grains. In animals,
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cell regulating genes was the common cause of shared traits seen in many domesticated animal species. However, several recent publications have either questioned this neural crest cell explanation or cast doubt on the existence of domestication syndrome itself. One recent publication points out that
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Domesticated animals tend to be smaller and less aggressive than their wild counterparts, they may also have floppy ears, variations to coat color, a smaller brain, and a shorter muzzle. Other traits may include changes in the endocrine system and an extended breeding cycle. These animal traits have
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Because the 'Reproductive Disruption' hypothesis explains domestication syndrome as a result of changed selective regimes, it can encompass multiple genetic or physiological ways that similar traits might emerge in the different domesticated species. For example, tamer behaviour might be caused by
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since the 1800s, and that the traits demonstrated by Belyayev had occurred in the foxes prior to the breeding experiment. A 2019 opinion paper by Lord and colleagues argued that the results of the "Russian farm fox experiment" were overstated, although the pre-domesticated origins of these Russian
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Kantar, Michael B.; Tyl, Catrin E.; Dorn, Kevin M.; Zhang, Xiaofei; Jungers, Jacob M.; Kaser, Joe M.; Schendel, Rachel R.; Eckberg, James O.; Runck, Bryan C.; Bunzel, Mirko; Jordan, Nick R.; Stupar, Robert M.; Marks, M. David; Anderson, James A.; Johnson, Gregg A.; Sheaffer, Craig C.; Schoenfuss,
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and can confer tameness, smaller jaws, floppy ears, and diminished craniofacial development, which distinguish domesticated dogs from wolves and are considered to reflect domestication syndrome. The study concluded that during early dog domestication, the initial selection was for behavior. This
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Gleeson and Wilson synthesised this debate and showed that animal domestication syndrome is not caused by selection for tameness, or by neural crest cell genetic pleiotropy. However, it could result from shared selective regime changes (which they termed 'reproductive disruption') leading to
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In 2020, Wright et al. argued Lord et al.'s critique refuted only a narrow and unrealistic definition of domestication syndrome because their criteria assumed it must be caused by genetic pleiotropy, and arises in response to 'selection for tameness'--as was claimed by Belyaev, Trut, and the
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Librado, Pablo; Gamba, Cristina; Gaunitz, Charleen; Der Sarkissian, Clio; Pruvost, Mélanie; Albrechtsen, Anders; Fages, Antoine; Khan, Naveed; Schubert, Mikkel; Jagannathan, Vidhya; Serres-Armero, Aitor; Kuderna, Lukas F. K.; Povolotskaya, Inna S.; Seguin-Orlando, Andaine; Lepetz, Sébastien
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Pearce, Stephen; Saville, Robert; Vaughan, Simon P.; Chandler, Peter M.; Wilhelm, Edward P.; Sparks, Caroline A.; Al-Kaff, Nadia; Korolev, Andrey; Boulton, Margaret I.; Phillips, Andrew L.; Hedden, Peter; Nicholson, Paul; Thomas, Stephen G. (1 December 2011).
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proposers of the neural crest hypothesis. In the same year, Zeder pointed out that it makes no sense to deny the existence of domestication syndrome on the basis that domestication syndrome traits were present in the pre-domesticated founding foxes.
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Statham, Mark J.; Trut, Lyudmila N.; Sacks, Ben N.; Kharlamova, Anastasiya V.; Oskina, Irina N.; Gulevich, Rimma G.; Johnson, Jennifer L.; Temnykh, Svetlana V.; Acland, Gregory M.; Kukekova, Anna V. (May 2011).
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been claimed to emerge across the different species in response to selection for tameness, which was purportedly demonstrated in a famous Russian fox breeding experiment, though this claim has been disputed.
194:. Genes for resistance to parasites might be linked to those for the domestication syndrome; it is predicted that domestic animals are less resistant to parasites than their wild relatives. 3321: 121: 258:
The hypothesis that neural crest genes underlie some of the phenotypic differences between domestic and wild horses and dogs is supported by the functional enrichment of
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could have mediated the domestication of mammals. Domestication involves taming, which has an endocrine component; and parasites can modify endocrine activity and
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reduced adrenal reactivity, by increased oxytocin production, or by a combination of these or other mechanisms, across the different populations and species.
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A dog's cranium is 15% smaller than an equally heavy wolf's, and the dog is less aggressive and more playful. Other species pairs show similar differences.
1030:, which is likely why they work so well in domestication: They are not new, and are relatively ready to have their magnitudes altered. In annual grains, 2915:
Stange, Madlen; Barrett, Rowan D. H.; Hendry, Andrew P. (February 2021). "The importance of genomic variation for biodiversity, ecosystems and people".
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Pendleton, Amanda L.; Shen, Feichen; Taravella, Angela M.; Emery, Sarah; Veeramah, Krishna R.; Boyko, Adam R.; Kidd, Jeffrey M. (December 2018).
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Machugh, David E.; Larson, Greger; Orlando, Ludovic (2016). "Taming the Past: Ancient DNA and the Study of Animal Domestication".
1314:"The taming of the neural crest: a developmental perspective on the origins of morphological covariation in domesticated mammals" 146:; however, whether this is true for domestication traits or merely for wild forms is less clear. Especially in the case of plant 2706: 1743: 3041: 3305: 171:
trait is influenced by those genes which act in the neural crest, which led to the phenotypes observed in modern dogs.
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Lenser, Teresa; Theißen, Günter (2013). "Molecular mechanisms involved in convergent crop domestication".
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Purugganan, Michael D.; Fuller, Dorian Q. (2009). "The nature of selection during plant domestication".
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Changed resource availability and predation pressure affecting female fertility and offspring survival.
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Intensified potential for maternal stress, selecting for altered reproductive physiology in females.
2557:"Domestication Effects on Stress Induced Steroid Secretion and Adrenal Gene Expression in Chickens" 1873:"A striking example of developmental bias in an evolutionary process: The "domestication syndrome"" 1578:"Shared reproductive disruption, not neural crest or tameness, explains the domestication syndrome" 299: 112:
In ten publications on domestication syndrome in animals, no single trait is included in every one.
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Chen, Erwang; Huang, Xuehui; Tian, Zhixi; Wing, Rod A.; Han, Bin (2019-04-29). "The Genomics of
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Lord, Kathryn A.; Larson, Greger; Coppinger, Raymond P.; Karlsson, Elinor K. (February 2020).
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Wilkins, Adam S; Wrangham, Richard; Fitch, W Tecumseh (2021-08-26). Peichel, C L (ed.).
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Lord, Kathryn A.; Larson, Greger; Coppinger, Raymond P.; Karlsson, Elinor K. (2020).
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Frantz, Laurent A. F.; Bradley, Daniel G.; Larson, Greger; Orlando, Ludovic (2020).
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Johnsson, Martin; Henriksen, Rie; Wright, Dominic (2021-08-26). Peichel, C L (ed.).
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Sánchez-Villagra, Marcelo R.; Geiger, Madeleine; Schneider, Richard A. (June 2016).
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Chen, Kunling; Wang, Yanpeng; Zhang, Rui; Zhang, Huawei; Gao, Caixia (2019-04-29).
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Study finds the brains of modern dog breeds are larger than those of ancient breeds
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Disrupted intra-sexual selection in males (reduced/altered male-male competition).
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Herbeck, Yu. E.; Gulevich, R. G.; Shepeleva, D. V.; Grinevich, V. V. (May 2017).
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Tonya C.; Ismail, Baraem; Heimpel, George E.; Wyse, Donald L. (2016-04-29).
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Disrupted inter-sexual selection in males (reduced/altered female choice).
3229: 3183: 996: 669: 191: 187: 143: 17: 2999: 1797:"The History of Farm Foxes Undermines the Animal Domestication Syndrome" 1524:"The History of Farm Foxes Undermines the Animal Domestication Syndrome" 1337: 100:, and increased yield, as well as changes in color, taste, and texture. 3173: 3103: 2866:"Molecular Characterization of Rht-1 Dwarfing Genes in Hexaploid Wheat" 2804:"CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture" 1444: 1149: 1107: 1083: 1038:
are by far the most common, and thus are the most interesting goals of
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Wilkins, Adam S; Wrangham, Richard W; Fitch, W Tecumseh (2014-07-01).
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Wright, Dominic; Henriksen, Rie; Johnsson, Martin (December 2020).
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Many similar traits – both in animals and plants – are produced by
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Species Provides Insights into Rice Domestication and Heterosis".
2463:"Defining the Domestication Syndrome: Comment on Lord et al. 2020" 1262:"Defining the Domestication Syndrome: Comment on Lord et al. 2020" 389: 343: 319: 107: 89: 34:
Reduction in size is regarded as a domestication syndrome trait -
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The domestication syndrome was reported to have appeared in the
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Hare, Brian; Wobber, Victoria; Wrangham, Richard (March 2012).
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found historical evidence that Belyayev's foxes originated in
346:/grain number, altered color compounds, taste, and texture, 234:'s breeding experiment. However, in 2015 canine researcher 1260:
Wright, Dominic; Henriksen, Rie; Johnsson, Martin (2020).
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Harlan, Jack R.; de Wet, J. M. J.; Price, E. Glen (1973).
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The Variation of Animals and Plants Under Domestication
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Proceedings of the Royal Society B: Biological Sciences
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Gleeson, Ben Thomas; Wilson, Laura A. B. (2023-03-29).
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https://academic.oup.com/jhered/article/70/5/301/813519
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The Variation of Animals and Plants Under Domestication
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Other research suggested that pleiotropic change in
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(2023a). 1445:10.1511/1999.2.160 1433:American Scientist 1150:10.1007/BF02098682 1036:altered expression 847:Grain/fruit number 831:teosinte branched1 799:Phaseolus vulgaris 767:Determinate growth 466:in rice and barley 352:determinate growth 114: 44: 3336: 3335: 2581:10.1038/srep15345 2473:(12): 1059–1060. 1991:(6336): 442–445. 1889:10.1111/ede.12319 1405:Missing or empty 1272:(12): 1059–1060. 1138:Die Kulturpflanze 1040:mutation breeding 1004:Unspecified trait 948:Delayed sprouting 905:in rice and wheat 774:TERMINAL FLOWER 1 549:(smaller) in rice 338:(stickiness, not 236:Raymond Coppinger 16:(Redirected from 3366: 3058: 3051: 3044: 3035: 3028: 3027: 2969: 2963: 2962: 2927:Nature Portfolio 2912: 2906: 2905: 2895: 2885: 2876:(4): 1820–1831. 2870:Plant Physiology 2860: 2854: 2853: 2827: 2799: 2752: 2751: 2697: 2658: 2657: 2617: 2611: 2610: 2600: 2552: 2546: 2545: 2505: 2499: 2498: 2458: 2452: 2451: 2449: 2448: 2431: 2425: 2424: 2384: 2375: 2370: 2364: 2362: 2341: 2335: 2334: 2295: 2289: 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2433: 2432: 2428: 2386: 2385: 2378: 2371: 2367: 2359: 2343: 2342: 2338: 2297: 2296: 2292: 2258: 2257: 2253: 2240: 2239: 2232: 2208: 2207: 2203: 2175: 2174: 2170: 2126: 2125: 2098: 2044: 2043: 2036: 1977: 1976: 1972: 1920: 1919: 1912: 1870: 1869: 1865: 1835: 1834: 1830: 1794: 1793: 1786: 1735: 1734: 1689: 1637: 1636: 1627: 1575: 1574: 1555: 1521: 1520: 1513: 1468: 1467: 1460: 1426: 1425: 1418: 1404: 1394: 1388: 1386: 1379: 1378: 1371: 1311: 1310: 1301: 1259: 1258: 1247: 1195: 1194: 1173: 1131: 1130: 1123: 1100:10.2307/2406971 1081: 1080: 1073: 1068: 1056: 842:) in maize/corn 490:in sorghum and 368: 296: 294:Syndrome traits 291: 260:candidate genes 232:Dmitry Belyayev 224: 200: 140: 106: 76:The process of 28: 23: 22: 15: 12: 11: 5: 3374: 3373: 3370: 3362: 3361: 3356: 3351: 3341: 3340: 3334: 3333: 3331: 3330: 3325: 3318: 3313: 3308: 3302: 3300: 3299:Related topics 3296: 3295: 3293: 3292: 3287: 3282: 3281: 3280: 3270: 3265: 3260: 3255: 3254: 3253: 3242: 3240: 3236: 3235: 3233: 3232: 3227: 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787:and orthologs 769: 768: 764: 763: 755: 753:foxtail millet 749:glutinous rice 733: 732: 728: 727: 719: 711: 703: 695: 687: 678: 677: 673: 672: 656: 655: 654:Flowering time 651: 650: 642: 633: 621: 609: 595: 594: 590: 589: 563: 556: 555: 551: 550: 541: 533: 525: 516: 515: 511: 510: 502: 494: 476: 468: 460: 457:reduced height 437: 436: 432: 431: 423: 415: 404: 392: 376: 375: 367: 364: 350:independence, 295: 292: 290: 287: 282: 281: 278: 275: 272: 230:cultivated by 223: 220: 199: 196: 139: 136: 117:Charles Darwin 105: 102: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 3372: 3371: 3360: 3357: 3355: 3352: 3350: 3349:Domestication 3347: 3346: 3344: 3329: 3326: 3324: 3323: 3319: 3317: 3314: 3312: 3309: 3307: 3304: 3303: 3301: 3297: 3291: 3288: 3286: 3283: 3279: 3276: 3275: 3274: 3271: 3269: 3266: 3264: 3261: 3259: 3256: 3252: 3249: 3248: 3247: 3244: 3243: 3241: 3237: 3231: 3228: 3226: 3223: 3222: 3220: 3218:Invertebrates 3216: 3210: 3207: 3205: 3202: 3200: 3199:Water buffalo 3197: 3195: 3192: 3190: 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160107. 1323: 1319: 1315: 1308: 1306: 1304: 1300: 1295: 1291: 1287: 1283: 1279: 1275: 1271: 1267: 1263: 1256: 1254: 1252: 1250: 1246: 1241: 1237: 1232: 1227: 1223: 1219: 1215: 1211: 1207: 1203: 1199: 1192: 1190: 1188: 1186: 1184: 1182: 1180: 1178: 1176: 1172: 1167: 1163: 1159: 1155: 1151: 1147: 1143: 1140:(in German). 1139: 1135: 1128: 1126: 1122: 1117: 1113: 1109: 1105: 1101: 1097: 1093: 1089: 1085: 1078: 1076: 1072: 1065: 1061: 1058: 1057: 1053: 1051: 1049: 1045: 1041: 1037: 1033: 1029: 1026:, especially 1025: 1018:in maize/corn 1017: 1016: 1012: 1008: 1007: 1003: 1002: 998: 994: 993: 989: 988: 985:Altered color 984: 983: 979: 975: 974: 969: 968: 963: 962: 957: 956: 952: 951: 947: 946: 942: 938: 934: 933: 929: 928: 924: 923: 919: 918: 914: 913: 909: 908: 904: 903: 899: 898: 894: 893: 889: 888: 884: 881: 880: 876: 873: 872: 868: 865: 863: 859: 856: 855: 851: 850: 846: 845: 841: 837: 836: 832: 828: 825: 824: 820: 816: 812: 811: 807: 806: 801: 800: 796:and eight in 795: 794: 789: 788: 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256: 252: 249: 245: 241: 237: 233: 229: 221: 219: 217: 213: 209: 205: 197: 195: 193: 189: 185: 181: 180:endoparasites 177: 172: 169: 168:embryogenesis 165: 161: 155: 153: 149: 145: 137: 135: 132: 127: 124: 123: 118: 110: 103: 101: 99: 95: 91: 87: 83: 79: 74: 71: 66: 62: 60: 56: 52: 48: 41: 37: 32: 19: 3320: 3164:Domestic pig 2979: 2973: 2967: 2922: 2916: 2910: 2873: 2869: 2858: 2811: 2807: 2711: 2705: 2701: 2629: 2625: 2615: 2567:(1): 15345. 2564: 2560: 2550: 2517: 2513: 2503: 2470: 2466: 2456: 2445:. 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Pelican. 2299:Hare, Brian 2242:Hare, Brian 2141:: 704–714. 2051:BMC Biology 1844:: 329–351. 793:Glycine max 248:fur farming 208:chimpanzees 3343:Categories 3149:Guinea pig 2929:: 89–105. 2447:2020-11-18 2188:(1): 1–7. 2139:Cell Press 1755:: 703–29. 1439:(2): 160. 1389:2024-03-05 1094:(2): 311. 1066:References 514:Grain size 459:) in wheat 390:maize/corn 374:Shattering 318:), larger 312:abscission 308:shattering 212:guinea pig 198:In animals 86:abscission 82:shattering 51:phenotypic 3225:Honey bee 3119:Dromedary 3024:205216444 3008:0028-0836 2959:223559538 2943:1471-0056 2834:1543-5008 2748:140266038 2732:1543-5008 2646:2079-0597 2589:2045-2322 2542:216513400 2495:221636622 2421:214809393 2155:1360-1385 2073:1741-7007 2057:(1): 64. 2029:206656021 2013:0036-8075 1947:1943-2631 1897:1520-541X 1771:1543-5008 1664:1943-2631 1602:0962-8452 1453:0003-0996 1346:2054-5703 1294:221636622 1222:1943-2631 1158:0075-7209 1088:Evolution 978:sprouting 935:produces 925:Fragrance 920:in barley 668:, wheat, 620:) in rice 348:daylength 332:flowering 324:threshing 289:In plants 240:fox farms 222:Challenge 192:microRNAs 184:helminths 174:The 2023 144:orthologs 94:threshing 40:chihuahua 36:grey wolf 18:Glutinous 3354:Genetics 3278:theories 3230:Silkworm 3184:Reindeer 3016:19212403 2982:(7231). 2951:33067582 2902:22013218 2850:73471425 2842:30835493 2740:31035826 2654:21631875 2607:26471470 2534:32668211 2487:32917395 2413:32265525 2347:(2014). 2323:16061417 2244:(2013). 2163:24035234 2091:29950181 2021:28450643 1965:34849912 1927:Genetics 1905:31545016 1858:27813680 1823:31810775 1779:26789233 1682:34849908 1644:Genetics 1620:36946116 1611:10031412 1588:(1995). 1548:31810775 1506:21625363 1398:cite web 1364:27429770 1286:32917395 1240:25024034 1202:Genetics 1166:42389667 1116:28564784 1054:See also 1042:, while 997:pericarp 995:- white 710:in wheat 670:ryegrass 509:in wheat 464:GA20ox-2 422:in wheat 188:protozoa 182:such as 3239:History 3174:Poultry 3104:Chicken 2988:Bibcode 2893:3327217 2598:4608001 2569:Bibcode 2363:Preface 2331:9311402 2285:3415520 2082:6022502 1993:Bibcode 1985:Science 1956:8633094 1673:8633120 1497:3101803 1355:4929905 1326:Bibcode 1231:4096361 1108:2406971 999:in rice 980:in rice 970:in the 882:in rice 866:in rice 857:in rice 826:in rice 762:in rice 726:in rice 718:in rice 702:in rice 694:in rice 582:in the 540:in rice 532:in rice 501:in rice 478:either 430:in rice 413:soybean 403:of rice 399:in the 386:sorghum 358:, less 316:lodging 310:/fruit 206:, like 204:Bonobos 84:/fruit 3134:Ferret 3114:Donkey 3099:Cattle 3079:Alpaca 3022:  3014:  3006:  2975:Nature 2957:  2949:  2941:  2900:  2890:  2848:  2840:  2832:  2746:  2738:  2730:  2652:  2644:  2605:  2595:  2587:  2540:  2532:  2493:  2485:  2419:  2411:  2355:  2329:  2321:  2283:  2161:  2153:  2137:(12). 2089:  2079:  2071:  2027:  2019:  2011:  1963:  1953:  1945:  1903:  1895:  1856:  1821:  1777:  1769:  1680:  1670:  1662:  1618:  1608:  1600:  1546:  1504:  1494:  1451:  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Index

Glutinous

grey wolf
chihuahua
phenotypic
domesticated plants
domesticated animals
neural crest
plant domestication
shattering
abscission
grain
threshing
synchronous flowering

Charles Darwin
The Variation of Animals and Plants Under Domestication
neural crest
orthologs
crops
loci
neural crest
central nervous system
embryogenesis
parasite-mediated domestication
endoparasites
helminths
protozoa
microRNAs
Bonobos

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