421:
2354:
398:
2444:
2414:
2339:
2294:
2264:
295:
320:
2459:
2399:
2309:
2384:
2369:
2324:
427:
326:
2429:
2279:
3315:
40:
66:
2353:
1693:
Zhang Y, Desharnais J, Marsilje TH, et al. (2003). "Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid".
2443:
2413:
2338:
2293:
2263:
2458:
2166:
Banerjee D, Nandagopal K (2009). "Phylogenetic analysis and in silico characterization of the GARS-AIRS-GART gene which codes for a tri-functional enzyme protein involved in de novo purine biosynthesis".
2398:
1725:"The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome"
2979:
2888:
1471:
Banerjee D, Nandagopal K (2007). "Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related
Alzheimer disease".
1508:
Dahms TE, Sainz G, Giroux EL, et al. (2005). "The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase".
2499:
434:
333:
2700:
2362:: The structure of human glycinamide ribonucleotide transformylase in complex with alpha,beta-N-(hydroxyacetyl)-D-ribofuranosylamine and 10-formyl-5,8,dideazafolate
3088:
227:, AIRS, GARS, GARTF, PAIS, PGFT, PRGS, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
2654:
2555:
2308:
2964:
2881:
2718:
2624:
1263:
2819:
2383:
946:
927:
256:
3054:
2974:
2598:
2368:
1625:"An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)"
2323:
3197:
1539:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1259:
1836:
Zhang Y, Desharnais J, Greasley SE, et al. (2002). "Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR".
3356:
2874:
2829:
2545:
3375:
2492:
2243:
1356:
1338:
2783:
420:
2855:
2575:
2571:
2428:
1182:
2452:: Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid and substrate beta-GAR
1189:
397:
3093:
2278:
2062:
3201:
2954:
2739:
2485:
3234:
3167:
3114:
2814:
2695:
1325:
1304:
1803:"A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression"
3172:
2984:
2959:
2804:
2799:
2723:
2603:
2422:: Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
2347:: Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
2302:: Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
2272:: Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
319:
294:
1321:
63:
3279:
2969:
2580:
2540:
1300:
1267:
2467:: human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid
3192:
2809:
2649:
236:
2211:
2824:
2004:
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".
433:
332:
3349:
2082:"Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts"
3008:
2843:
2758:
2668:
2634:
2550:
2521:
2236:
426:
325:
3274:
2687:
2512:
2215:
995:
244:
2407:: Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
1867:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
3294:
3038:
2997:
976:
972:
17:
2866:
3380:
3013:
2744:
3342:
3248:
3143:
2644:
308:
3289:
2639:
2229:
1964:
1441:
223:
3266:
3239:
3109:
2608:
1276:
1165:
1136:
1132:
1102:
1073:
1069:
3080:
2939:
2903:
2192:
2029:
1496:
268:
2477:
1953:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1161:
1140:
1128:
1098:
1077:
1065:
3119:
3049:
2921:
2710:
2525:
2184:
2154:
2111:
2068:
2058:
2021:
1992:
1939:
1896:
1853:
1824:
1789:
1746:
1711:
1681:
1646:
1611:
1568:
1525:
1488:
1459:
1405:
1271:
216:
56:
3326:
3124:
2176:
2144:
2136:
2101:
2093:
2050:
2013:
1982:
1972:
1929:
1921:
1910:"Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes"
1886:
1878:
1845:
1814:
1779:
1771:
1736:
1703:
1671:
1636:
1601:
1593:
1558:
1550:
1517:
1480:
1449:
1395:
1387:
513:
444:
388:
343:
2762:
1376:"Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes"
488:
264:
1760:"Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene"
1968:
1582:"Determination of genetic predisposition to patent ductus arteriosus in preterm infants"
1445:
3284:
3214:
3177:
2149:
2124:
2106:
2081:
1934:
1909:
1606:
1581:
1563:
1538:
1391:
2054:
1987:
1952:
1891:
1866:
1784:
1759:
1400:
1375:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
775:
770:
765:
749:
744:
739:
734:
724:
719:
714:
709:
704:
3369:
3129:
3064:
3023:
2943:
2672:
691:
2196:
2590:
2033:
1500:
506:
285:
1819:
1802:
1374:
Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV (July 1991).
248:
2097:
272:
2508:
2125:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
1361:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1343:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1676:
1659:
589:
3162:
2908:
2899:
2180:
1484:
405:
302:
252:
1775:
2768:
1741:
1724:
1301:
ENSG00000159131 GRCh38: Ensembl release 89: ENSG00000262473, ENSG00000159131
891:
649:
527:
472:
459:
371:
358:
260:
2188:
2158:
2115:
2025:
1996:
1977:
1943:
1900:
1857:
1828:
1715:
1685:
1650:
1615:
1597:
1572:
1529:
1492:
1463:
2072:
1793:
1750:
1409:
1229:
1224:
1213:
1040:
1021:
729:
3322:
2847:
2140:
1882:
1641:
1624:
1554:
1007:
958:
3314:
2317:: The apo structure of human glycinamide ribonucleotide transformylase
1925:
1849:
1707:
1521:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
2911:
2677:
2629:
2041:
Zalkin H, Dixon JE (1992). "De novo purine nucleotide biosynthesis".
1454:
1429:
1245:
1197:
913:
2017:
1623:
Franke B, Vermeulen SH, Steegers-Theunissen RP, et al. (2009).
2392:: Human Glycinamide Ribonucleotide Transformylase domain at pH 8.5
876:
872:
3252:
3243:
1629:
Birth
Defects Research Part A: Clinical and Molecular Teratology
1252:
240:
2870:
2481:
2225:
39:
2221:
2377:: complex structure of human GAR Tfase and substrate beta-GAR
2332:: human glycinamide ribonucleotide Transformylase at pH 4.2
2080:
Vieira AR, McHenry TG, Daack-Hirsch S, et al. (2008).
2045:. Progress in Nucleic Acid Research and Molecular Biology.
1951:
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
1660:"Toward a confocal subcellular atlas of the human proteome"
1801:
Gomez HL, Santillana SL, Vallejos CS, et al. (2006).
842:
purine ribonucleoside monophosphate biosynthetic process
735:
hydroxymethyl-, formyl- and related transferase activity
496:
3330:
2980:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
1865:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
745:
phosphoribosylformylglycinamidine cyclo-ligase activity
1908:
Manieri W, Moore ME, Soellner MB, et al. (2007).
1428:
Hattori M, Fujiyama A, Taylor TD, et al. (2000).
1537:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
1242:
Trifunctional purine biosynthetic protein adenosine-3
661:
1723:
Brodsky G, Barnes T, Bleskan J, et al. (1997).
1658:
Barbe L, Lundberg E, Oksvold P, et al. (2008).
1258:
This protein is a trifunctional polypeptide. It has
715:
phosphoribosylglycinamide formyltransferase activity
3265:
3227:
3151:
3142:
3102:
3079:
3034:
2993:
2936:
2929:
2920:
2842:
2792:
2776:
2757:
2732:
2709:
2686:
2667:
2617:
2589:
2564:
2533:
2520:
1154:
1121:
1091:
1058:
1580:Dagle JM, Lepp NT, Cooper ME, et al. (2009).
1317:
1315:
1313:
1296:
1294:
1292:
827:ribonucleoside monophosphate biosynthetic process
443:
342:
2701:3-methyl-2-oxobutanoate hydroxymethyltransferase
2437:: HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE
2123:Ewing RM, Chu P, Elisma F, et al. (2007).
3089:Hypoxanthine-guanine phosphoribosyltransferase
1322:GRCm38: Ensembl release 89: ENSMUSG00000022962
3350:
2882:
2655:Cyclopropane-fatty-acyl-phospholipid synthase
2493:
2287:: Human glycinamide ribonucleotide synthetase
2237:
8:
2556:Phosphatidylethanolamine N-methyltransferase
1270:(EC 6.3.3.1) activity which is required for
18:Glycinamide ribonucleotide formyltransferase
2965:Phosphoribosylglycinamide formyltransferase
2719:Phosphoribosylglycinamide formyltransferase
2625:Phosphatidyl ethanolamine methyltransferase
2212:Phosphoribosylglycinamide+formyltransferase
1264:phosphoribosylglycinamide formyltransferase
750:phosphoribosylamine-glycine ligase activity
3357:
3343:
3155:
3148:
2933:
2926:
2889:
2875:
2867:
2820:3-hydroxymethylcephem carbamoyltransferase
2773:
2683:
2530:
2500:
2486:
2478:
2244:
2230:
2222:
887:
687:
484:
383:
280:
74:
2214:at the U.S. National Library of Medicine
2148:
2105:
1986:
1976:
1933:
1890:
1818:
1783:
1740:
1675:
1640:
1605:
1562:
1453:
1430:"The DNA sequence of human chromosome 21"
1399:
2975:Phosphoribosylaminoimidazole carboxylase
2259:
1288:
27:Mammalian protein found in Homo sapiens
2830:N-acetylornithine carbamoyltransferase
2599:Betaine-homocysteine methyltransferase
2546:Phenylethanolamine N-methyltransferase
857:purine nucleobase biosynthetic process
792:purine nucleotide biosynthetic process
29:
832:tetrahydrofolate biosynthetic process
448:
409:
404:
347:
306:
301:
7:
3311:
3309:
3198:Orotidine 5'-phosphate decarboxylase
2784:methylmalonyl-CoA carboxytransferase
2856:Arginine:glycine amidinotransferase
2576:Acetylserotonin O-methyltransferase
2572:5-hydroxyindole-O-methyltransferase
3329:. You can help Knowledge (XXG) by
1392:10.1002/j.1460-2075.1991.tb07685.x
1260:phosphoribosylamine—glycine ligase
1151:
1118:
1088:
1055:
1031:
1012:
986:
963:
937:
918:
802:'de novo' IMP biosynthetic process
666:
584:
522:
501:
25:
3094:Adenine phosphoribosyltransferase
2043:Prog. Nucleic Acid Res. Mol. Biol
1248:that in humans is encoded by the
3313:
3202:Uridine monophosphate synthetase
2955:Ribose-phosphate diphosphokinase
2740:Glutamate formimidoyltransferase
2457:
2442:
2427:
2412:
2397:
2382:
2367:
2352:
2337:
2322:
2307:
2292:
2277:
2262:
432:
425:
419:
396:
331:
324:
318:
293:
38:
3235:Dihydropyrimidine dehydrogenase
3168:Carbamoyl phosphate synthase II
3115:Purine nucleoside phosphorylase
2815:Putrescine carbamoyltransferase
2696:Serine hydroxymethyltransferase
837:response to inorganic substance
3173:Aspartate carbamoyltransferase
2960:Amidophosphoribosyltransferase
2805:Ornithine carbamoyltransferase
2800:Aspartate carbamoyltransferase
2724:Inosine monophosphate synthase
2604:Homocysteine methyltransferase
650:More reference expression data
1:
3280:Nucleoside-diphosphate kinase
2970:AIR synthetase (FGAM cyclase)
2581:Catechol-O-methyl transferase
2541:Histamine N-methyltransferase
2055:10.1016/s0079-6603(08)60578-4
1820:10.1158/1078-0432.CCR-05-0295
1268:AIR synthetase (FGAM cyclase)
817:response to organic substance
417:
316:
3376:Genes on human chromosome 21
3193:Dihydroorotate dehydrogenase
2810:Oxamate carbamoyltransferase
2650:Thiopurine methyltransferase
2098:10.1097/GIM.0b013e3181833793
1957:Proc. Natl. Acad. Sci. U.S.A
862:adenine biosynthetic process
2825:Lysine carbamoyltransferase
2511:: one carbon transferases (
847:cerebral cortex development
3397:
3308:
1677:10.1074/mcp.M700325-MCP200
3210:
3188:
3158:
3009:Adenylosuccinate synthase
2635:Histone methyltransferase
2551:Amine N-methyltransferase
2257:
2181:10.1007/s12033-009-9160-1
1758:Kan JL, Moran RG (1997).
1485:10.1007/s10571-007-9217-2
1357:"Mouse PubMed Reference:"
1339:"Human PubMed Reference:"
1228:
1223:
1219:
1212:
1196:
1177:
1158:
1125:
1114:
1095:
1062:
1051:
1038:
1034:
1019:
1015:
1006:
993:
989:
970:
966:
957:
944:
940:
925:
921:
912:
897:
890:
886:
870:
797:glycine metabolic process
690:
686:
674:
669:
660:
647:
596:
587:
534:
525:
495:
487:
483:
466:
453:
416:
395:
386:
382:
365:
352:
315:
292:
283:
279:
234:
231:
221:
214:
209:
82:
77:
60:
55:
50:
46:
37:
32:
3275:Ribonucleotide reductase
2688:Hydroxymethyltransferase
2216:Medical Subject Headings
1190:Chr 16: 91.42 – 91.44 Mb
450:16 C3.3|16 53.18 cM
3295:Dihydrofolate reductase
1183:Chr 21: 33.5 – 33.54 Mb
3325:-related article is a
3014:Adenylosuccinate lyase
2745:Aminomethyltransferase
1978:10.1073/pnas.242603899
1776:10.1093/nar/25.15.3118
1598:10.1542/peds.2008-0313
822:cerebellum development
3249:Beta-ureidopropionase
3144:Pyrimidine metabolism
2904:amino acid metabolism
2645:DNA methyltransferase
1742:10.1093/hmg/6.12.2043
1664:Mol. Cell. Proteomics
807:brainstem development
776:extracellular exosome
411:Chromosome 16 (mouse)
309:Chromosome 21 (human)
3290:Thymidylate synthase
3267:Deoxyribonucleotides
2640:Thymidylate synthase
1473:Cell. Mol. Neurobiol
705:transferase activity
550:smooth muscle tissue
78:List of PDB id codes
51:Available structures
3240:Dihydropyrimidinase
3110:Adenosine deaminase
2609:Methionine synthase
1969:2002PNAS...9916899M
1446:2000Natur.405..311H
1277:purine biosynthesis
570:islet of Langerhans
554:epithelium of colon
542:ganglionic eminence
3081:Nucleotide salvage
2141:10.1038/msb4100134
1883:10.1101/gr.2596504
1642:10.1002/bdra.20556
1555:10.1101/gr.4039406
996:ENSMUSG00000022962
785:Biological process
759:Cellular component
730:catalytic activity
710:nucleotide binding
698:Molecular function
624:extraocular muscle
3338:
3337:
3303:
3302:
3261:
3260:
3223:
3222:
3138:
3137:
3120:Guanine deaminase
3075:
3074:
3050:IMP dehydrogenase
2922:Purine metabolism
2864:
2863:
2838:
2837:
2753:
2752:
2711:Formyltransferase
2663:
2662:
2475:
2474:
1963:(26): 16899–903.
1926:10.1021/bi0619270
1850:10.1021/bi020522m
1813:(3 Pt 1): 832–8.
1764:Nucleic Acids Res
1708:10.1021/bi034219c
1522:10.1021/bi050307g
1239:
1238:
1235:
1234:
1208:
1207:
1173:
1172:
1148:
1147:
1110:
1109:
1085:
1084:
1047:
1046:
1028:
1027:
1002:
1001:
983:
982:
953:
952:
934:
933:
882:
881:
720:metal ion binding
682:
681:
678:
677:
656:
655:
643:
642:
581:
580:
479:
478:
378:
377:
205:
204:
201:
200:
61:Ortholog search:
16:(Redirected from
3388:
3359:
3352:
3345:
3317:
3310:
3156:
3149:
3125:Xanthine oxidase
3043:
3002:
2948:
2934:
2927:
2891:
2884:
2877:
2868:
2774:
2684:
2531:
2502:
2495:
2488:
2479:
2461:
2446:
2431:
2416:
2401:
2386:
2371:
2356:
2341:
2326:
2311:
2296:
2281:
2266:
2246:
2239:
2232:
2223:
2200:
2162:
2152:
2119:
2109:
2076:
2037:
2000:
1990:
1980:
1947:
1937:
1904:
1894:
1861:
1844:(48): 14206–15.
1832:
1822:
1807:Clin. Cancer Res
1797:
1787:
1754:
1744:
1719:
1689:
1679:
1654:
1644:
1619:
1609:
1576:
1566:
1533:
1504:
1467:
1457:
1455:10.1038/35012518
1414:
1413:
1403:
1371:
1365:
1364:
1353:
1347:
1346:
1335:
1329:
1319:
1308:
1298:
1221:
1220:
1192:
1185:
1168:
1152:
1143:
1119:
1115:RefSeq (protein)
1105:
1089:
1080:
1056:
1032:
1013:
987:
964:
938:
919:
888:
688:
667:
652:
628:ventricular zone
608:primitive streak
600:Ileal epithelium
592:
590:Top expressed in
585:
558:body of pancreas
538:ventricular zone
530:
528:Top expressed in
523:
502:
485:
475:
462:
451:
436:
429:
423:
412:
400:
384:
374:
361:
350:
335:
328:
322:
311:
297:
281:
275:
273:GART - orthologs
226:
219:
196:
75:
69:
48:
47:
42:
30:
21:
3396:
3395:
3391:
3390:
3389:
3387:
3386:
3385:
3366:
3365:
3364:
3363:
3306:
3304:
3299:
3257:
3219:
3206:
3184:
3134:
3098:
3071:
3035:
3030:
2994:
2989:
2937:
2916:
2895:
2865:
2860:
2834:
2788:
2766:
2749:
2728:
2705:
2676:
2659:
2613:
2585:
2560:
2516:
2506:
2476:
2471:
2468:
2462:
2453:
2447:
2438:
2432:
2423:
2417:
2408:
2402:
2393:
2387:
2378:
2372:
2363:
2357:
2348:
2342:
2333:
2327:
2318:
2312:
2303:
2297:
2288:
2282:
2273:
2267:
2253:
2250:
2208:
2203:
2169:Mol. Biotechnol
2165:
2129:Mol. Syst. Biol
2122:
2079:
2065:
2040:
2018:10.1038/nbt1046
2006:Nat. Biotechnol
2003:
1950:
1907:
1877:(10B): 2121–7.
1864:
1835:
1800:
1770:(15): 3118–23.
1757:
1735:(12): 2043–50.
1729:Hum. Mol. Genet
1722:
1702:(20): 6043–56.
1692:
1657:
1622:
1579:
1536:
1516:(29): 9841–50.
1507:
1470:
1440:(6784): 311–9.
1427:
1423:
1421:Further reading
1418:
1417:
1373:
1372:
1368:
1355:
1354:
1350:
1337:
1336:
1332:
1320:
1311:
1299:
1290:
1285:
1262:(EC 6.3.4.13),
1230:View/Edit Mouse
1225:View/Edit Human
1188:
1181:
1178:Location (UCSC)
1164:
1160:
1139:
1135:
1131:
1127:
1101:
1097:
1076:
1072:
1068:
1064:
977:ENSG00000159131
975:
973:ENSG00000262473
866:
780:
754:
725:ligase activity
648:
639:
634:
630:
626:
622:
618:
614:
610:
606:
602:
588:
577:
572:
568:
566:trabecular bone
564:
560:
556:
552:
548:
544:
540:
526:
470:
457:
449:
439:
438:
437:
430:
410:
387:Gene location (
369:
356:
348:
338:
337:
336:
329:
307:
284:Gene location (
235:
222:
215:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3394:
3392:
3384:
3383:
3378:
3368:
3367:
3362:
3361:
3354:
3347:
3339:
3336:
3335:
3318:
3301:
3300:
3298:
3297:
3292:
3287:
3285:DCMP deaminase
3282:
3277:
3271:
3269:
3263:
3262:
3259:
3258:
3256:
3255:
3246:
3237:
3231:
3229:
3225:
3224:
3221:
3220:
3218:
3217:
3215:CTP synthetase
3211:
3208:
3207:
3205:
3204:
3195:
3189:
3186:
3185:
3183:
3182:
3181:
3180:
3178:Dihydroorotase
3175:
3170:
3159:
3153:
3146:
3140:
3139:
3136:
3135:
3133:
3132:
3127:
3122:
3117:
3112:
3106:
3104:
3100:
3099:
3097:
3096:
3091:
3085:
3083:
3077:
3076:
3073:
3072:
3070:
3069:
3068:
3067:
3057:
3052:
3046:
3044:
3032:
3031:
3029:
3028:
3027:
3026:
3016:
3011:
3005:
3003:
2991:
2990:
2988:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2951:
2949:
2931:
2924:
2918:
2917:
2915:
2914:
2906:
2896:
2894:
2893:
2886:
2879:
2871:
2862:
2861:
2859:
2858:
2852:
2850:
2840:
2839:
2836:
2835:
2833:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2796:
2794:
2790:
2789:
2787:
2786:
2780:
2778:
2771:
2755:
2754:
2751:
2750:
2748:
2747:
2742:
2736:
2734:
2730:
2729:
2727:
2726:
2721:
2715:
2713:
2707:
2706:
2704:
2703:
2698:
2692:
2690:
2681:
2665:
2664:
2661:
2660:
2658:
2657:
2652:
2647:
2642:
2637:
2632:
2627:
2621:
2619:
2615:
2614:
2612:
2611:
2606:
2601:
2595:
2593:
2587:
2586:
2584:
2583:
2578:
2568:
2566:
2562:
2561:
2559:
2558:
2553:
2548:
2543:
2537:
2535:
2528:
2518:
2517:
2507:
2505:
2504:
2497:
2490:
2482:
2473:
2472:
2470:
2469:
2463:
2456:
2454:
2448:
2441:
2439:
2433:
2426:
2424:
2418:
2411:
2409:
2403:
2396:
2394:
2388:
2381:
2379:
2373:
2366:
2364:
2358:
2351:
2349:
2343:
2336:
2334:
2328:
2321:
2319:
2313:
2306:
2304:
2298:
2291:
2289:
2283:
2276:
2274:
2268:
2261:
2258:
2255:
2254:
2251:
2249:
2248:
2241:
2234:
2226:
2220:
2219:
2207:
2206:External links
2204:
2202:
2201:
2163:
2120:
2077:
2063:
2038:
2001:
1948:
1905:
1862:
1833:
1798:
1755:
1720:
1690:
1670:(3): 499–508.
1655:
1620:
1592:(4): 1116–23.
1577:
1534:
1505:
1479:(8): 1117–26.
1468:
1424:
1422:
1419:
1416:
1415:
1386:(7): 1629–34.
1366:
1348:
1330:
1309:
1287:
1286:
1284:
1281:
1266:(EC 2.1.2.2),
1237:
1236:
1233:
1232:
1227:
1217:
1216:
1210:
1209:
1206:
1205:
1203:
1201:
1194:
1193:
1186:
1179:
1175:
1174:
1171:
1170:
1156:
1155:
1149:
1146:
1145:
1123:
1122:
1116:
1112:
1111:
1108:
1107:
1093:
1092:
1086:
1083:
1082:
1060:
1059:
1053:
1049:
1048:
1045:
1044:
1036:
1035:
1029:
1026:
1025:
1017:
1016:
1010:
1004:
1003:
1000:
999:
991:
990:
984:
981:
980:
968:
967:
961:
955:
954:
951:
950:
942:
941:
935:
932:
931:
923:
922:
916:
910:
909:
904:
899:
895:
894:
884:
883:
880:
879:
868:
867:
865:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
788:
786:
782:
781:
779:
778:
773:
768:
762:
760:
756:
755:
753:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
701:
699:
695:
694:
684:
683:
680:
679:
676:
675:
672:
671:
664:
658:
657:
654:
653:
645:
644:
641:
640:
638:
637:
633:
629:
625:
621:
617:
613:
609:
605:
601:
597:
594:
593:
582:
579:
578:
576:
575:
571:
567:
563:
562:gastric mucosa
559:
555:
551:
547:
543:
539:
535:
532:
531:
519:
518:
510:
499:
493:
492:
489:RNA expression
481:
480:
477:
476:
468:
464:
463:
455:
452:
447:
441:
440:
431:
424:
418:
414:
413:
408:
402:
401:
393:
392:
380:
379:
376:
375:
367:
363:
362:
354:
351:
346:
340:
339:
330:
323:
317:
313:
312:
305:
299:
298:
290:
289:
277:
276:
233:
229:
228:
220:
212:
211:
207:
206:
203:
202:
199:
198:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3393:
3382:
3381:Protein stubs
3379:
3377:
3374:
3373:
3371:
3360:
3355:
3353:
3348:
3346:
3341:
3340:
3334:
3332:
3328:
3324:
3319:
3316:
3312:
3307:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3272:
3270:
3268:
3264:
3254:
3250:
3247:
3245:
3241:
3238:
3236:
3233:
3232:
3230:
3226:
3216:
3213:
3212:
3209:
3203:
3199:
3196:
3194:
3191:
3190:
3187:
3179:
3176:
3174:
3171:
3169:
3166:
3165:
3164:
3161:
3160:
3157:
3154:
3150:
3147:
3145:
3141:
3131:
3130:Urate oxidase
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3107:
3105:
3101:
3095:
3092:
3090:
3087:
3086:
3084:
3082:
3078:
3066:
3065:GMP reductase
3063:
3062:
3061:
3058:
3056:
3053:
3051:
3048:
3047:
3045:
3042:
3040:
3033:
3025:
3024:AMP deaminase
3022:
3021:
3020:
3017:
3015:
3012:
3010:
3007:
3006:
3004:
3001:
2999:
2992:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2952:
2950:
2947:
2945:
2941:
2935:
2932:
2928:
2925:
2923:
2919:
2913:
2910:
2907:
2905:
2901:
2898:
2897:
2892:
2887:
2885:
2880:
2878:
2873:
2872:
2869:
2857:
2854:
2853:
2851:
2849:
2845:
2841:
2831:
2828:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2797:
2795:
2791:
2785:
2782:
2781:
2779:
2775:
2772:
2770:
2764:
2760:
2756:
2746:
2743:
2741:
2738:
2737:
2735:
2731:
2725:
2722:
2720:
2717:
2716:
2714:
2712:
2708:
2702:
2699:
2697:
2694:
2693:
2691:
2689:
2685:
2682:
2680:- and Related
2679:
2674:
2673:Hydroxymethyl
2670:
2666:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2626:
2623:
2622:
2620:
2616:
2610:
2607:
2605:
2602:
2600:
2597:
2596:
2594:
2592:
2588:
2582:
2579:
2577:
2573:
2570:
2569:
2567:
2563:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2538:
2536:
2532:
2529:
2527:
2523:
2519:
2514:
2510:
2503:
2498:
2496:
2491:
2489:
2484:
2483:
2480:
2466:
2460:
2455:
2451:
2445:
2440:
2436:
2430:
2425:
2421:
2415:
2410:
2406:
2400:
2395:
2391:
2385:
2380:
2376:
2370:
2365:
2361:
2355:
2350:
2346:
2340:
2335:
2331:
2325:
2320:
2316:
2310:
2305:
2301:
2295:
2290:
2286:
2280:
2275:
2271:
2265:
2260:
2256:
2247:
2242:
2240:
2235:
2233:
2228:
2227:
2224:
2217:
2213:
2210:
2209:
2205:
2198:
2194:
2190:
2186:
2182:
2178:
2175:(3): 306–19.
2174:
2170:
2164:
2160:
2156:
2151:
2146:
2142:
2138:
2134:
2130:
2126:
2121:
2117:
2113:
2108:
2103:
2099:
2095:
2092:(9): 668–74.
2091:
2087:
2083:
2078:
2074:
2070:
2066:
2064:9780125400428
2060:
2056:
2052:
2048:
2044:
2039:
2035:
2031:
2027:
2023:
2019:
2015:
2012:(1): 94–101.
2011:
2007:
2002:
1998:
1994:
1989:
1984:
1979:
1974:
1970:
1966:
1962:
1958:
1954:
1949:
1945:
1941:
1936:
1931:
1927:
1923:
1920:(1): 156–63.
1919:
1915:
1911:
1906:
1902:
1898:
1893:
1888:
1884:
1880:
1876:
1872:
1868:
1863:
1859:
1855:
1851:
1847:
1843:
1839:
1834:
1830:
1826:
1821:
1816:
1812:
1808:
1804:
1799:
1795:
1791:
1786:
1781:
1777:
1773:
1769:
1765:
1761:
1756:
1752:
1748:
1743:
1738:
1734:
1730:
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1691:
1687:
1683:
1678:
1673:
1669:
1665:
1661:
1656:
1652:
1648:
1643:
1638:
1635:(3): 216–26.
1634:
1630:
1626:
1621:
1617:
1613:
1608:
1603:
1599:
1595:
1591:
1587:
1583:
1578:
1574:
1570:
1565:
1560:
1556:
1552:
1548:
1544:
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1469:
1465:
1461:
1456:
1451:
1447:
1443:
1439:
1435:
1431:
1426:
1425:
1420:
1411:
1407:
1402:
1397:
1393:
1389:
1385:
1381:
1377:
1370:
1367:
1362:
1358:
1352:
1349:
1344:
1340:
1334:
1331:
1327:
1323:
1318:
1316:
1314:
1310:
1306:
1302:
1297:
1295:
1293:
1289:
1282:
1280:
1278:
1275:
1274:
1269:
1265:
1261:
1256:
1254:
1251:
1247:
1243:
1231:
1226:
1222:
1218:
1215:
1211:
1204:
1202:
1199:
1195:
1191:
1187:
1184:
1180:
1176:
1169:
1167:
1163:
1157:
1153:
1150:
1144:
1142:
1138:
1134:
1130:
1124:
1120:
1117:
1113:
1106:
1104:
1100:
1094:
1090:
1087:
1081:
1079:
1075:
1071:
1067:
1061:
1057:
1054:
1052:RefSeq (mRNA)
1050:
1043:
1042:
1037:
1033:
1030:
1024:
1023:
1018:
1014:
1011:
1009:
1005:
998:
997:
992:
988:
985:
979:
978:
974:
969:
965:
962:
960:
956:
949:
948:
943:
939:
936:
930:
929:
924:
920:
917:
915:
911:
908:
905:
903:
900:
896:
893:
889:
885:
878:
874:
869:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
789:
787:
784:
783:
777:
774:
772:
769:
767:
764:
763:
761:
758:
757:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
702:
700:
697:
696:
693:
692:Gene ontology
689:
685:
673:
668:
665:
663:
659:
651:
646:
635:
631:
627:
623:
619:
615:
611:
607:
603:
599:
598:
595:
591:
586:
583:
573:
569:
565:
561:
557:
553:
549:
545:
541:
537:
536:
533:
529:
524:
521:
520:
517:
515:
511:
509:
508:
504:
503:
500:
498:
494:
490:
486:
482:
474:
469:
465:
461:
456:
446:
442:
435:
428:
422:
415:
407:
403:
399:
394:
390:
385:
381:
373:
368:
364:
360:
355:
345:
341:
334:
327:
321:
314:
310:
304:
300:
296:
291:
287:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
230:
225:
218:
213:
208:
197:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3331:expanding it
3320:
3305:
3059:
3055:GMP synthase
3036:
3018:
2995:
2985:IMP synthase
2938:
2591:Homocysteine
2464:
2449:
2434:
2419:
2404:
2389:
2374:
2359:
2344:
2329:
2314:
2299:
2284:
2269:
2172:
2168:
2132:
2128:
2089:
2085:
2046:
2042:
2009:
2005:
1960:
1956:
1917:
1914:Biochemistry
1913:
1874:
1870:
1841:
1838:Biochemistry
1837:
1810:
1806:
1767:
1763:
1732:
1728:
1699:
1696:Biochemistry
1695:
1667:
1663:
1632:
1628:
1589:
1585:
1549:(1): 55–65.
1546:
1542:
1513:
1510:Biochemistry
1509:
1476:
1472:
1437:
1433:
1383:
1379:
1369:
1360:
1351:
1342:
1333:
1272:
1257:
1249:
1241:
1240:
1166:NP_001344280
1159:
1137:NP_001129478
1133:NP_001129477
1126:
1103:NM_001357351
1096:
1074:NM_001136006
1070:NM_001136005
1063:
1039:
1020:
994:
971:
945:
926:
906:
901:
812:biosynthesis
512:
505:
232:External IDs
83:
2509:Transferase
2252:PDB gallery
740:ATP binding
471:91,443,840
458:91,418,074
370:33,543,491
357:33,503,931
210:Identifiers
3370:Categories
3228:Catabolism
3103:Catabolism
2909:nucleotide
2900:Metabolism
2086:Genet. Med
2049:: 259–87.
1871:Genome Res
1586:Pediatrics
1543:Genome Res
1328:, May 2017
1307:, May 2017
1283:References
852:metabolism
516:(ortholog)
253:HomoloGene
3152:Anabolism
2930:Anabolism
2793:Carbamoyl
2769:Carbamoyl
2135:(1): 89.
1162:NP_034386
1141:NP_780294
1129:NP_000810
1099:NM_010256
1078:NM_175085
1066:NM_000819
892:Orthologs
766:cytoplasm
261:GeneCards
2197:34759623
2189:19301155
2159:17353931
2116:18978678
2026:15592455
1997:12477932
1944:17198385
1901:15489334
1858:12450384
1829:16467096
1716:12755606
1686:18029348
1651:19161160
1616:19336370
1573:16344560
1530:16026156
1493:17902044
1464:10830953
1324:–
1303:–
1214:Wikidata
871:Sources:
612:yolk sac
604:epiblast
349:21q22.11
3323:protein
3060:reverse
3019:reverse
2912:enzymes
2848:Amidine
2777:Carboxy
2763:Carboxy
2526:Methyl-
2150:1847948
2107:2734954
2073:1574589
2034:7200157
1965:Bibcode
1935:2518408
1794:9224613
1751:9328467
1607:2734952
1564:1356129
1501:5102914
1442:Bibcode
1410:2050105
1326:Ensembl
1305:Ensembl
1273:de novo
1008:UniProt
959:Ensembl
898:Species
877:QuickGO
771:cytosol
491:pattern
217:Aliases
2678:Formyl
2630:DNMT3B
2218:(MeSH)
2195:
2187:
2157:
2147:
2114:
2104:
2071:
2061:
2032:
2024:
1995:
1988:139241
1985:
1942:
1932:
1899:
1892:528928
1889:
1856:
1827:
1792:
1785:146841
1782:
1749:
1714:
1684:
1649:
1614:
1604:
1571:
1561:
1528:
1499:
1491:
1462:
1434:Nature
1408:
1401:452831
1398:
1380:EMBO J
1246:enzyme
1244:is an
1200:search
1198:PubMed
1041:Q64737
1022:P22102
914:Entrez
662:BioGPS
636:morula
632:embryo
620:somite
616:embryo
574:tonsil
546:rectum
241:138440
3321:This
2844:2.1.4
2759:2.1.3
2733:Other
2669:2.1.2
2618:Other
2522:2.1.1
2193:S2CID
2030:S2CID
1497:S2CID
947:14450
907:Mouse
902:Human
873:Amigo
514:Mouse
507:Human
454:Start
389:Mouse
353:Start
286:Human
249:95654
3327:stub
3253:UPB1
3244:DPYS
3037:IMP→
2996:IMP→
2767:and
2515:2.1)
2465:1njs
2450:1rby
2435:2v9y
2420:1rc0
2405:1rbq
2390:1mej
2375:1men
2360:1zly
2345:1rc1
2330:1meo
2315:1zlx
2300:1rbz
2285:2qk4
2270:1rbm
2185:PMID
2155:PMID
2112:PMID
2069:PMID
2059:ISBN
2022:PMID
1993:PMID
1940:PMID
1897:PMID
1854:PMID
1825:PMID
1790:PMID
1747:PMID
1712:PMID
1682:PMID
1647:PMID
1612:PMID
1569:PMID
1526:PMID
1489:PMID
1460:PMID
1406:PMID
1253:gene
1250:GART
928:2618
497:Bgee
445:Band
406:Chr.
344:Band
303:Chr.
265:GART
237:OMIM
224:GART
194:4ZYW
190:4ZYU
186:4ZYT
182:4ZYZ
178:4ZYX
174:4ZYY
170:4ZZ0
166:4ZYV
162:4ZZ1
158:4ZZ3
154:4ZZ2
150:4EW3
146:4EW2
142:4EW1
138:2V9Y
134:2QK4
130:1ZLY
126:1ZLX
122:1RC1
118:1RC0
114:1RBZ
110:1RBY
106:1RBQ
102:1RBM
98:1NJS
94:1MEO
90:1MEN
86:1MEJ
67:RCSB
64:PDBe
33:GART
3163:CAD
3039:GMP
2998:AMP
2944:IMP
2940:R5P
2177:doi
2145:PMC
2137:doi
2102:PMC
2094:doi
2051:doi
2014:doi
1983:PMC
1973:doi
1930:PMC
1922:doi
1887:PMC
1879:doi
1846:doi
1815:doi
1780:PMC
1772:doi
1737:doi
1704:doi
1672:doi
1637:doi
1602:PMC
1594:doi
1590:123
1559:PMC
1551:doi
1518:doi
1481:doi
1450:doi
1438:405
1396:PMC
1388:doi
670:n/a
467:End
366:End
269:OMA
257:637
245:MGI
57:PDB
3372::
2902::
2846::
2761::
2675:-,
2671::
2565:O-
2534:N-
2524::
2513:EC
2191:.
2183:.
2173:42
2171:.
2153:.
2143:.
2131:.
2127:.
2110:.
2100:.
2090:10
2088:.
2084:.
2067:.
2057:.
2047:42
2028:.
2020:.
2010:23
2008:.
1991:.
1981:.
1971:.
1961:99
1959:.
1955:.
1938:.
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