938:
26:
244:(PAS), four glycophorins have been identified. These have been named glycophorin A, B, C, and D in order of the quantity present in the membrane, glycophorin A being the most and glycophorin D the least common. A fifth (
173:
979:
364:
117:
105:
248:) has been identified within the human genome but cannot easily be detected on routine gel staining. In total, the glycophorins constitute ~2% of the total
1003:
225:, which gives the red blood cells a very hydrophilic-charged coat. This enables them to circulate without adhering to other cells or vessel walls.
396:
85:
252:
membrane protein mass. These proteins are also known under different nomenclatures but they are probably best known as the glycophorins.
972:
773:
813:
663:
1008:
965:
221:. It is a membrane-spanning protein and carries sugar molecules. It is heavily glycosylated (60%). Glycophorins are rich in
193:
910:
389:
900:
241:
863:
823:
803:
778:
358:
181:
374:
998:
838:
382:
228:
A particular mutation in
Glycophorins is thought to produce a 40% reduction in risk of severe malaria.
177:
98:
843:
768:
655:
632:
596:
568:
214:
129:
793:
868:
697:
333:
210:
168:
949:
945:
937:
783:
600:
553:
323:
315:
160:
740:
712:
628:
304:"Resistance to malaria through structural variation of red blood cell invasion receptors"
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409:
354:
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303:
249:
218:
110:
992:
895:
883:
563:
274:
90:
302:
Leffler EM, Band G, Busby GB, Kivinen K, Le QS, Clarke GM, et al. (June 2017).
54:
808:
720:
587:
417:
413:
368:
156:
134:
122:
30:
Dimeric transmembrane domain of human glycophorin A (20 NMR-determined structures)
66:
920:
915:
905:
848:
833:
702:
558:
548:
425:
222:
748:
858:
853:
828:
818:
730:
319:
337:
94:
25:
677:
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645:
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573:
237:
61:
725:
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405:
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873:
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682:
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457:
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150:
49:
378:
285:
Glycophorin D is now known to be a variant of
Glycophorin C.
260:
The following four human genes encode glycophorin proteins:
953:
761:
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711:
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627:
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586:
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433:
424:
187:
167:
149:
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84:
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60:
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40:
35:
18:
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592:
430:
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365:UMich Orientation of Proteins in Membranes
236:After separation of red cell membranes by
141:
24:
357:at the U.S. National Library of Medicine
327:
703:Structural maintenance of chromosomes 3
294:
238:SDS-polyacrylamide gel electrophoresis
15:
7:
934:
932:
1004:Single-pass transmembrane proteins
952:. You can help Knowledge (XXG) by
14:
814:Cholesterylester transfer protein
664:Chondroitin sulfate proteoglycans
936:
1:
242:periodic acid-Schiff staining
145:Available protein structures:
911:Tumor necrosis factor alpha
1025:
931:
901:Thyroxine-binding proteins
864:Serum amyloid P component
824:Colony-stimulating factor
140:
23:
804:B-cell activating factor
779:Alpha 1-antichymotrypsin
359:Medical Subject Headings
320:10.1126/science.aam6393
1009:Membrane protein stubs
948:–related article is a
839:Membrane glycoproteins
844:Myelin protein zero
769:Activin and inhibin
569:Phytohaemagglutinin
794:Asialoglycoprotein
369:protein/pdbid-1afo
314:(6343): eaam6393.
240:and staining with
961:
960:
929:
928:
869:Sialoglycoprotein
757:
756:
698:Platelet factor 4
582:
581:
211:sialoglycoprotein
203:
202:
199:
198:
194:structure summary
1016:
982:
975:
968:
946:membrane protein
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933:
784:Apolipoprotein H
593:
554:Intrinsic factor
431:
399:
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28:
16:
1024:
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106:OPM superfamily
31:
12:
11:
5:
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891:Thrombopoietin
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410:glycoconjugate
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349:External links
347:
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267:
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256:Family members
254:
233:
232:Identification
230:
219:red blood cell
201:
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10:
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1021:
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1005:
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999:Glycoproteins
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935:
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912:
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907:
904:
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899:
897:
896:Thyroglobulin
894:
892:
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885:
884:Glycophorin C
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588:Proteoglycans
585:
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567:
565:
564:Peptidoglycan
562:
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419:
418:glycopeptides
415:
414:glycoproteins
411:
407:
400:
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393:
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339:
335:
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321:
317:
313:
309:
305:
298:
295:
288:
286:
281:
280:Glycophorin E
278:
276:
275:Glycophorin C
273:
271:
270:Glycophorin B
268:
266:
265:Glycophorin A
263:
262:
261:
255:
253:
251:
247:
246:glycophorin E
243:
239:
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71:
68:
65:
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59:
56:
53:
51:
47:
43:
39:
34:
27:
22:
19:Glycophorin A
17:
954:expanding it
943:
878:
809:4-1BB ligand
721:Fibromodulin
426:Mucoproteins
367:
311:
307:
297:
284:
259:
235:
227:
206:
204:
921:Vitronectin
916:Uteroglobin
906:Transcortin
879:Glycophorin
849:Osteonectin
834:Lactoferrin
559:Orosomucoid
549:Haptoglobin
355:Glycophorin
250:erythrocyte
223:sialic acid
207:glycophorin
118:OPM protein
36:Identifiers
993:Categories
749:Syndecan 1
289:References
157:structures
130:Membranome
859:Protein S
854:Protein C
829:Hemopexin
819:Clusterin
731:Keratocan
79:PDOC00281
67:IPR001195
678:Brevican
673:Neurocan
668:Aggrecan
646:Perlecan
641:Testican
619:Versican
614:Biglycan
574:Ovomucin
338:28522690
215:membrane
174:RCSB PDB
62:InterPro
726:Lumican
609:Decorin
406:Protein
329:5575826
308:Science
213:of the
74:PROSITE
55:PF01102
799:Avidin
478:MUC5AC
361:(MeSH)
336:
326:
189:PDBsum
163:
153:
99:SUPFAM
41:Symbol
944:This
762:Other
693:CSPG5
688:CSPG4
542:Other
533:MUC20
528:MUC19
523:MUC17
518:MUC16
513:MUC15
508:MUC13
503:MUC12
483:MUC5B
468:MUC3B
463:MUC3A
448:CD164
435:Mucin
217:of a
209:is a
95:SCOPe
86:SCOP2
950:stub
874:CD43
789:CD70
774:ADAM
683:CD44
498:MUC8
493:MUC7
488:MUC6
473:MUC4
458:MUC2
453:MUC1
443:CD43
416:and
334:PMID
182:PDBj
178:PDBe
161:ECOD
151:Pfam
123:5eh4
91:1afo
50:Pfam
44:GYPA
324:PMC
316:doi
312:356
169:PDB
135:156
995::
741:HS
713:KS
666::
656:CS
633:CS
629:HS
601:DS
597:CS
412::
408:,
332:.
322:.
310:.
306:.
205:A
180:;
176:;
159:/
111:25
97:/
93:/
981:e
974:t
967:v
956:.
631:/
599:/
398:e
391:t
384:v
340:.
318::
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