1124:->threonine). M-VIII shares the Anek determinant with MiVII. Mi-III, Mi-VI and Mi-X are due to rearrangements of glycophorin A and B in the order GlyA (alpha)-GlyB (delta)-GlyA (alpha). Mil-IX in contrast is a reverse alpha-delta-alpha hybrid gene. Mi-V, MiV(J.L.) and St are due to unequal but homologous crossing-over between alpha and delta glycophorin genes. The MiV and MiV(J.L.) genes are arranged in the same 5' alpha-delta 3' frame whereas St gene is in a reciprocal 5'delta-alpha 3' configuration.
184:
209:
3740:
431:
424:
417:
215:
29:
928:. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
940:
The GypA gene itself consists of 7 exons and has 97% sequence homology with GypB and GypE from the 5' untranslated transcription region (UTR) to the coding sequence encoding the first 45 amino acids. The exon at this point encodes the transmembrane domain. Within the intron downstream of this pint is
1226:
Anti-M although occurring naturally has rarely been implicated in transfusion reactions. Anti-N is not considered to cause transfusion reactions. Severe reactions have been reported with anti-Miltenberger. Anti Mi-I (Vw) and Mi-III has been recognised as a cause of haemolytic disease of the newborn.
1091:
The
Miltenberger (Mi) subsystem originally consisting of five phenotypes (Mi, V, Mur, Hil and Hut) now has 11 recognised phenotypes numbered I to XI (The antigen 'Mur' is named after to the patient the original serum was isolated from - a Mrs Murrel.) The name originally given to this complex refers
1042:
The Dantu antigen was described in 1984. The Dantu antigen has an apparent molecular weight of 29 kilodaltons (kDa) and 99 amino acids. The first 39 amino acids of the Dantu antigen are derived from glycophorin B and residues 40-99 are derived from glycophorin A. Dantu is associated with very weak s
1011:
The M and N antigens differ at two amino acid residues: the M allele has serine at position 1 (C at nucleotide 2) and glycine at position 5 (G at nucleotide 14) while the N allele has leucine at position 1 (T at nucleotide 2) and glutamate at position 5 (A at nucleotide 14). Both glycophorin A and B
936:
GypA, GypB and GypE are members of the same family and are located on the long arm of chromosome 4 (chromosome 4q31). The family evolved via two separate gene duplication events. The initial duplication gave rise to two genes one of subsequently evolved into GypA and the other which give rise via a
1119:
residue into a serine at the positions 49 and 52 respectively. The threonine-49 residue is glycosylated. This appears to be the origin of one of the Mi-VII specific antigens (Anek) which is known to lie between residues 40-61 of glycophorin A and comprises sialic acid residue(s) attached to
1021:
There are about 40 known variants in the MNS blood group system. These have arisen largely as a result of mutations within the 4 kb region coding for the extracellular domain. These include the antigens Mg, Dantu, Henshaw (He), Miltenberger, Ny, Os, Orriss (Or), Raddon (FR) and Stones (St).
1173:
A related antigen is Sat. This gene has six exons of which exon I to exon IV are identical to the N allele of glycophorin A whereas its 3' portion, including exon V and exon VI, are derived from the glycophorin B gene. The mature protein SAT protein contains 104 amino acid residues.
2208:
Flower R, Lin P-H, Heathcote D, Chan M, Teo D, Selkirk A, Shepherd R, Henry S. Insertion of KODE peptide constructs into red cell membranes: Creating artificial variant MNS blood group antigens. ISBT Regional
Congress, Macao SAR China, 2008. (P-396) Vox Sanguinis 2008; 95:Suppl 1,
1164:
Stones (St) has been shown to be the product of a hybrid gene of which the 5'-half is derived from the glycophorin B whereas the 3'-half is derived from the glycophorin A. Several isoforms are known. This antigen is now considered to be part of the
Miltenberger complex.
1423:
Tokunaga E, Sasakawa S, Tamaka K, Kawamata H, Giles CM, Ikin EW, Poole J, Anstee DJ, Mawby W, Tanner MJ (December 1979). "Two apparently healthy
Japanese individuals of type MkMk have erythrocytes which lack both the blood group MN and Ss-active sialoglycoproteins".
55:
1043:
antigen, a protease-resistant N antigen and either very weak or no U antigen. There are at least three variants: MD, NE and Ph. The Dantu phenotype occurs with a frequency of Dantu phenotype is ~0.005 in
American Blacks and < 0.001 in Germans.
2146:
Heathcote D, Flower R, Henry S (2008). "Development of novel alloantibody screening cells β the first example of the addition of peptide antigens to human red cells using KODE technology. ISBT Regional
Congress, Macao SAR China, 2008". (P-303)".
1120:
O-glycosidically linked oligosaccharide(s). This also explains the loss of a high frequency antigen ((EnaKT)) found in normal glycophorin A which is located within the residues 46β56. Mi-VIII is due to a mutation at amino acid residue 49 (
2394:
Daniels GL, Bruce LJ, Mawby WJ, Green CA, Petty A, Okubo Y, Kornstad L, Tanner MJ (May 2000). "The low-frequency MNS blood group antigens Ny(a) (MNS18) and Os(a) (MNS38) are associated with GPA amino acid substitutions".
1553:
Unger P, Procter JL, Moulds JJ, Moulds M, Blanchard D, Guizzo ML, McCall LA, Cartron JP, Dahr W (July 1987). "The Dantu erythrocyte phenotype of the NE variety. II. Serology, immunochemistry, genetics, and frequency".
1095:
Mi-I (Mi), Mi-II(V), Mi-VII and Mi-VIII are carried on glycophorin A. Mi-I is due to a mutation at amino acid 28 (threonine to methionine: CβT at nucleotide 83) resulting in a loss of the glycosylation at the
3000:
Johnson ST, McFarland JG, Kelly KJ, et al. (2002). "Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination".
1597:
Reid ME, Lomas-Francis C, Daniels GL, Chen V, Shen J, Ho YC, Hare V, Batts R, Yacob M, Smart E (1995). "Expression of the erythrocyte antigen
Henshaw (He; MNS6): serological and immunochemical studies".
937:
second duplication event to GypB and GypE. These events appear to have occurred within a relatively short time span. The second duplication appears to have occurred via an unequal crossing over event.
2438:
Rearden A, Frandson S, Carry JB (1987). "Severe hemolytic disease of the newborn due to anti-Vw and detection of glycophorin A antigens on the
Miltenberger I sialoglycoprotein by Western blotting".
2166:
Heathcote D, Carroll T, Wang JJ, Flower R, Rodionov I, Tuzikov A, Bovin N, Henry S (2010). "Novel antibody screening cells, MUT+Mur kodecytes, created by attaching peptides onto erythrocytes".
3448:
Vignal A, Rahuel C, el Maliki B, et al. (1989). "Molecular analysis of glycophorin A and B gene structure and expression in homozygous
Miltenberger class V (Mi. V) human erythrocytes".
2930:"Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification"
4698:
1111:
residue. This alteration in glycoslation is detectable by the presence of a new 32kDa glycoprotein stainable with PAS. Mi-VII is due to a double mutation in glycophorin A converting an
3254:"Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification"
1982:"Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification"
3837:
2602:"A malaria invasion receptor, the 175-kilodalton erythrocyte binding antigen of Plasmodium falciparum recognizes the terminal Neu5Ac(alpha 2-3)Gal- sequences of glycophorin A"
2219:
Mak KH, Banks JA, Lubenko A, Chua KM, Torres de
Jardine AL, Yan KF (March 1994). "A survey of the incidence of Miltenberger antibodies among Hong Kong Chinese blood donors".
1092:
to the reaction erythrocytes gave to the standard Miltenberger antisera used to test them. The subclasses were based on additional reactions with other standard antisera.
222:
1367:
Dean L. Blood Groups and Red Cell Antigens . Bethesda (MD): National Center for Biotechnology Information (US); 2005. Chapter 12, The MNS blood group. Available from:
3559:"Characterization of cDNA clones for human glycophorin A. Use for gene localization and for analysis of normal of glycophorin-A-deficient (Finnish type) genomic DNA"
974:
The MNS blood group was the second set of antigens discovered. M and N were identified in 1927 by Landsteiner and Levine. S and s in were described later in 1947.
4688:
2770:
Ohyama K, Endo T, Ohkuma S, Yamakawa T (May 1993). "Isolation and influenza virus receptor activity of glycophorins B, C and D from human erythrocyte membranes".
3739:
2526:"The Wrb antigen, a receptor for Plasmodium falciparum malaria, is located on a helical region of the major membrane sialoglycoprotein of human red blood cells"
2023:"Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats"
1867:
Dahr W, Beyreuther K, Moulds JJ (July 1987). "Structural analysis of the major human erythrocyte membrane sialoglycoprotein from Miltenberger class VII cells".
1467:
Contreras M, Green C, Humphreys J, Tippett P, Daniels G, Teesdale P, Armitage S, Lubenko A (1984). "Serology and genetics of an MNSs-associated antigen Dantu".
1051:
The Henshaw (He) antigen is due to a mutation of the N terminal region. There are three differences in the first three amino acid residues: the usual form has
2854:
Tavakkol A, Burness AT (November 1990). "Evidence for a direct role for sialic acid in the attachment of encephalomyocarditis virus to human erythrocytes".
4668:
3805:
3797:
145:
1149:
aboriginal tribes (up to 90%). In contrast its frequency is 2-3% in Han Taiwanese (Minnan). The Mi-III phenotype occurs in 6.28% of Hong Kong Chinese.
600:
5530:
3854:
3830:
1510:
Dahr W, Pilkington PM, Reinke H, Blanchard D, Beyreuther K (May 1989). "A novel variety of the Dantu gene complex (DantuMD) detected in a Caucasian".
1902:
Dahr W, Vengelen-Tyler V, Dybkjaer E, Beyreuther K (August 1989). "Structural analysis of glycophorin A from Miltenberger class VIII erythrocytes".
3594:"Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure"
3520:
Huang CH, Puglia KV, Bigbee WL, et al. (1989). "A family study of multiple mutations of alpha and delta glycophorins (glycophorins A and B)".
5261:
1079:. This antigen is rare in Caucasians but occurs at a frequency of 2.1% in US and UK of African origin. It occurs at the rate of 7.0% in blacks in
1380:
Blumenfeld OO, Adamany AM, Puglia KV, Socha WW (April 1983). "The chimpanzee M blood-group antigen is a variant of the human M-N glycoproteins".
5249:
5027:
3329:
Dill K, Hu SH, Berman E, et al. (1990). "One- and two-dimensional NMR studies of the N-terminal portion of glycophorin A at 11.7 Tesla".
5313:
5308:
5254:
5034:
3815:
3719:
1333:
5867:
5862:
4767:
4693:
3823:
2305:
Bacon JM, Macdonald EB, Young SG, Connell T (1987). "Evidence that the low frequency antigen Orriss is part of the MN blood group system".
5796:
5791:
5786:
5781:
4708:
825:
3368:"Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences"
3155:"Gene conversion confined to a direct repeat of the acceptor splice site generates allelic diversity at human glycophorin (GYP) locus"
5761:
1242:
4997:
2735:
Wybenga LE, Epand RF, Nir S, Chu JW, Sharom FJ, Flanagan TD, Epand RM (July 1996). "Glycophorin as a receptor for Sendai virus".
1354:
3419:
Matsui Y, Natori S, Obinata M (1989). "Isolation of the cDNA clone for mouse glycophorin, erythroid-specific membrane protein".
5565:
5059:
4745:
1320:
5204:
4740:
3219:"Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins"
2481:
Baldwin ML, Barrasso C, Gavin J (1981). "The first example of a Raddon-like antibody as a cause of a transfusion reaction".
2064:"Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins"
208:
183:
5701:
5173:
5168:
5113:
4847:
4296:
2103:
Chandanyingyong D, Pejrachandra S (1975). "Studies on the Miltenberger complex frequency in Thailand and family studies".
1316:
924:) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss
5395:
5118:
133:
4713:
3798:
https://web.archive.org/web/20161008211618/http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/G/Glycoproteins.html
1104::C->A at nucleotide 83). Similar to the case of Mi-I this mutation results in a loss of the glycosylation at the
221:
5425:
3850:
1277:
909:
1937:
Dybkjaer E, Poole J, Giles CM (1981). "A new Miltenberger class detected by a second example of Anek type serum".
1198:
Os (MNS38) is due to a mutation at nucleotide 273 (C->T) lying within exon 3 resulting in the replacement of a
4291:
3712:
3647:"Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A."
214:
1134:
Peptide constructs representative of Mi mutations MUT and MUR have been attached onto red blood cells (known as
5475:
4370:
3790:
2262:
Skov F, Green C, Daniels G, Khalid G, Tippett P (1991). "Miltenberger class IX of the MNS blood group system".
947:
repeat. The cross over event which created the genes ancestral to GypA and GypB/E occurred within this region.
3188:
Barton P, Collins A, Hoogenraad N (1991). "A variant of glycophorin A resulting from the deletion of exon 4".
52:
5439:
643:
3120:"Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype"
1735:"Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype"
4782:
4777:
4772:
4762:
4069:
3997:
2573:
Facer CA (November 1983). "Merozoites of P. falciparum require glycophorin for invasion into red cells".
124:, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2, glycophorin A (MNS blood group)
4126:
4044:
1779:"Structures of Miltenberger class I and II specific major human erythrocyte membrane sialoglycoproteins"
1237:
1182:
Orriss (Or) appears to be a mutant of glycophorin A but its precise nature has not yet been determined.
1235:
The Wright b antigen (Wrb) is located on glycophorin A and acts as a receptor for the malaria parasite
5363:
5076:
3705:
3657:
3605:
3379:
2348:
Green C, Daniels G, Skov F, Tippett P (1994). "Mg+ MNS blood group phenotype: further observations".
1214:
Ny (MNS18) is due to a mutation at nucleotide 194 (T->A) which results in the substitution of an
197:
120:
5390:
5209:
3085:"Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices"
785:
781:
732:
728:
2651:"Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane"
4797:
4531:
3786:
3545:
3354:
3026:
2959:
2506:
2463:
2420:
2373:
2330:
2287:
2244:
2191:
2128:
1962:
1715:
1623:
1579:
1535:
1492:
1449:
1405:
157:
1777:
Dahr W, Newman RA, Contreras M, Kordowicz M, Teesdale P, Beyreuther K, KrΓΌger J (January 1984).
789:
736:
958:
and some of the higher primates suggesting that the duplication events occurred only recently.
3766:
3685:
3633:
3580:
3537:
3508:
3465:
3436:
3407:
3346:
3317:
3275:
3240:
3205:
3176:
3141:
3106:
3071:
3018:
2988:
2951:
2906:
2871:
2836:
2787:
2752:
2717:
2680:
2631:
2582:
2555:
2498:
2455:
2412:
2365:
2322:
2279:
2236:
2183:
2120:
2085:
2044:
2003:
1954:
1919:
1884:
1849:
1800:
1756:
1707:
1672:
1615:
1571:
1527:
1484:
1441:
1397:
1023:
113:
45:
5570:
5303:
5224:
4787:
3980:
3906:
3675:
3665:
3623:
3613:
3570:
3529:
3498:
3490:
3479:"Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta"
3457:
3428:
3397:
3387:
3338:
3307:
3299:
3265:
3230:
3197:
3166:
3131:
3096:
3061:
3051:
3010:
2980:
2941:
2898:
2863:
2826:
2818:
2779:
2744:
2707:
2670:
2662:
2621:
2613:
2545:
2537:
2490:
2447:
2404:
2357:
2314:
2271:
2228:
2175:
2112:
2075:
2034:
1993:
1946:
1911:
1876:
1839:
1831:
1790:
1746:
1699:
1662:
1654:
1607:
1563:
1519:
1476:
1433:
1389:
430:
423:
301:
232:
3040:"Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin"
2889:
Paul RW, Lee PW (July 1987). "Glycophorin is the reovirus receptor on human erythrocytes".
2494:
2232:
5630:
4166:
4161:
4084:
884:
416:
276:
153:
3661:
3609:
3383:
2408:
1026:
also have an MN blood antigen system. In chimpanzees M reacts strong but N only weakly.
5415:
4837:
4348:
4151:
3575:
3558:
3503:
3478:
3461:
2626:
2601:
2550:
2525:
2451:
2361:
2318:
2275:
2116:
1950:
1880:
1844:
1819:
1795:
1778:
1703:
1667:
1642:
1611:
1480:
1437:
1080:
1014:
3680:
3646:
3628:
3593:
3402:
3367:
3312:
3288:
3270:
3253:
3171:
3154:
3101:
3084:
3066:
3039:
2984:
2831:
2806:
2675:
2650:
1998:
1981:
1034:
In individuals who lack both glycophorin A and B the phenotype has been designated M.
534:
529:
524:
508:
503:
498:
482:
477:
472:
28:
5856:
5385:
4842:
3933:
3809:
3775:
3432:
3201:
3014:
2902:
2783:
2666:
2179:
1190:
The Mg antigen is carried on glycophorin A and lacks three O-glycolated side chains.
1083:
and 2.7% in West Africans. At least 3 variants of this antigen have been identified.
459:
3549:
3030:
2963:
2822:
2510:
2467:
2377:
2334:
2291:
2248:
2195:
1966:
1583:
1539:
1496:
1453:
1409:
1241:. Cells lacking glycophorins A (En) are resistant to invasion by this parasite. The
5741:
5049:
5039:
4570:
4536:
3358:
2649:
SÑnchez G, Aragonès L, Costafreda MI, Ribes E, Bosch A, Pintó RM (September 2004).
2424:
2132:
1627:
1261:
943:
294:
174:
3235:
3218:
2971:
Blumenfeld OO, Huang CH (1997). "Molecular genetics of glycophorin MNS variants".
2807:"Group C rotavirus requires sialic acid for erythrocyte and cell receptor binding"
2080:
2063:
2039:
2022:
1915:
1719:
161:
5751:
5400:
5178:
5153:
4852:
4474:
4400:
3874:
3136:
3119:
2712:
2699:
1751:
1734:
1338:
National Center for Biotechnology Information, U.S. National Library of Medicine
1293:
1269:
1265:
1253:
925:
5681:
5405:
5086:
4827:
4703:
4336:
4331:
4326:
4181:
3965:
1368:
1257:
1105:
1052:
191:
141:
3303:
5520:
5515:
5510:
5500:
5495:
5490:
5485:
3670:
3392:
2946:
2929:
1273:
1215:
1073:
982:
564:
394:
315:
260:
247:
149:
3618:
3056:
3022:
2684:
2416:
2187:
1820:"Miltenberger Class I and II erythrocytes carry a variant of glycophorin A"
1676:
1658:
3689:
3637:
3584:
3541:
3512:
3469:
3440:
3411:
3350:
3321:
3279:
3244:
3209:
3180:
3145:
3110:
3075:
2992:
2955:
2910:
2875:
2840:
2791:
2756:
2721:
2700:"Binding of bovine parvovirus to erythrocyte membrane sialylglycoproteins"
2635:
2617:
2586:
2559:
2502:
2459:
2369:
2326:
2283:
2240:
2124:
2089:
2048:
2007:
1958:
1923:
1888:
1853:
1804:
1760:
1711:
1619:
1575:
1531:
1488:
1401:
868:
5826:
5726:
5540:
5525:
4728:
4723:
4631:
4321:
3748:: DIMERIC TRANSMEMBRANE DOMAIN OF HUMAN GLYCOPHORIN A, NMR, 20 STRUCTURES
1445:
1281:
1249:
recognises the terminal Neu5Ac(alpha 2-3)Gal-sequences of glycophorin A.
1135:
1128:
1121:
1116:
1112:
951:
857:
686:
3289:"The mechanism of production of multiple mRNAs for human glycophorin A."
2867:
1138:) and are able to detect antibodies against these Miltenberger antigens
5776:
5771:
5766:
5666:
5480:
5470:
5297:
5276:
5271:
5239:
5044:
4964:
4959:
4954:
4949:
4944:
4862:
4555:
4395:
4390:
4385:
4380:
4375:
3846:
3780:
3770:
3533:
3342:
2021:
Huang CH, Skov F, Daniels G, Tippett P, Blumenfeld OO (November 1992).
1567:
1523:
1393:
1199:
1153:
1066:
1059:
986:
955:
894:
672:
629:
3494:
2748:
2541:
1835:
90:
86:
82:
78:
74:
5716:
5676:
5661:
5645:
5640:
5620:
5615:
5550:
5358:
5328:
5292:
5283:
5096:
5064:
4928:
4923:
4893:
4872:
4832:
4792:
4658:
4636:
4595:
4519:
4514:
4509:
4504:
4499:
4494:
4363:
4358:
4353:
4301:
4286:
4156:
4146:
4109:
4104:
4022:
4017:
1690:
Cleghorn TE (1966). "A memorandum on the Miltenberger blood groups".
1203:
1146:
1101:
838:
586:
966:
There are about one million copies of this protein per erythrocyte.
1145:(0.006%), the frequency of Mi-III is exceptionally high in several
1100:
residue. Mi-II is due to a mutation at amino acid 28 (threonine to
5841:
5816:
5736:
5731:
5721:
5711:
5696:
5691:
5686:
5671:
5625:
5610:
5575:
5560:
5555:
5545:
5465:
5460:
5455:
5434:
5430:
5420:
5333:
5234:
5229:
5188:
5138:
5133:
5128:
5123:
5108:
5101:
5081:
5069:
5012:
5007:
5002:
4992:
4987:
4980:
4918:
4908:
4903:
4898:
4888:
4867:
4857:
4822:
4817:
4812:
4807:
4802:
4757:
4752:
4718:
4683:
4678:
4673:
4663:
4651:
4646:
4626:
4621:
4616:
4611:
4565:
4457:
4452:
4271:
4255:
4248:
4243:
4238:
4233:
4228:
4223:
4198:
4176:
4171:
4064:
3990:
3985:
3975:
1142:
549:
545:
5836:
5831:
5821:
5811:
5806:
5801:
5756:
5746:
5706:
5635:
5605:
5600:
5595:
5590:
5585:
5580:
5535:
5505:
5410:
5378:
5373:
5353:
5343:
5338:
5323:
5318:
5219:
5214:
5183:
5163:
5158:
5148:
5143:
5022:
4975:
4935:
4590:
4585:
4580:
4575:
4560:
4551:
4546:
4541:
4526:
4484:
4479:
4469:
4464:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4343:
4316:
4311:
4306:
4281:
4276:
4213:
4208:
4203:
4193:
4188:
4141:
4136:
4131:
4121:
4116:
4099:
4094:
4089:
4079:
4074:
4059:
4054:
4049:
4039:
4034:
4029:
4012:
4007:
4002:
3953:
3921:
3916:
3911:
3894:
3889:
3884:
3879:
921:
901:
137:
3819:
3701:
439:
5348:
3960:
3948:
3943:
3938:
3928:
3901:
3869:
3697:
1818:
Blanchard D, Asseraf A, Prigent MJ, Cartron JP (August 1983).
1643:"A study of two unusual blood-group antigens in West Africans"
1227:
Raddon has been associated with severe transfusion reactions.
3765:
Overview of all the structural information available in the
1733:
Huang CH, Spruell P, Moulds JJ, Blumenfeld OO (July 1992).
284:
3153:
Huang CH, Kikuchi M, McCreary J, Blumenfeld OO (1992).
3118:
Huang CH, Spruell P, Moulds JJ, Blumenfeld OO (1992).
3083:
Lemmon MA, Flanagan JM, Hunt JF, et al. (1992).
406:
3557:
Rahuel C, London J, d'Auriol L, et al. (1988).
5654:
5448:
5197:
4881:
4604:
4264:
3862:
1355:"Entrez Gene: GYPA glycophorin A (MNS blood group)"
803:
774:
750:
721:
1312:
1310:
1308:
1152:Mi-IX (MNS32) occurs with a frequency of 0.43% in
2600:Orlandi PA, Klotz FW, Haynes JD (February 1992).
2524:Ridgwell K, Tanner MJ, Anstee DJ (January 1983).
231:
1252:Several viruses bind to glycophorin A including
2389:
2387:
16:Protein-coding gene in the species Homo sapiens
1641:Chalmers JN, Ikin EW, Mourant AE (July 1953).
1141:Although uncommon in Caucasians (0.0098%) and
3831:
3713:
8:
1772:
1770:
1369:https://www.ncbi.nlm.nih.gov/books/NBK2274/
1317:GRCh38: Ensembl release 89: ENSG00000170180
920:Glycophorins A (GYPA; this protein) and B (
3838:
3824:
3816:
3806:United States National Library of Medicine
3720:
3706:
3698:
560:
455:
272:
169:
63:
3855:list of human clusters of differentiation
3789:at the U.S. National Library of Medicine
3679:
3669:
3627:
3617:
3574:
3502:
3401:
3391:
3311:
3269:
3234:
3170:
3135:
3100:
3065:
3055:
2945:
2830:
2711:
2698:Thacker TC, Johnson FB (September 1998).
2674:
2625:
2549:
2079:
2038:
1997:
1843:
1794:
1750:
1666:
904:. GYPA has also recently been designated
3804:This article incorporates text from the
1349:
1347:
3735:
1304:
1115:residue into a threonine residue and a
2495:10.1046/j.1537-2995.1981.21181127491.x
2233:10.1046/j.1537-2995.1994.34394196622.x
2062:Huang CH, Blumenfeld OO (April 1991).
1980:Huang CH, Blumenfeld OO (April 1991).
977:The frequencies of these antigens are
18:
236:
195:
190:
7:
2409:10.1046/j.1537-2995.2000.40050555.x
3576:10.1111/j.1432-1033.1988.tb13866.x
3462:10.1111/j.1432-1033.1989.tb15024.x
2973:Transfusion Clinique et Biologique
2452:10.1111/j.1423-0410.1987.tb04900.x
2362:10.1111/j.1423-0410.1994.tb00316.x
2319:10.1111/j.1423-0410.1987.tb04902.x
2276:10.1111/j.1423-0410.1991.tb00258.x
2117:10.1111/j.1423-0410.1975.tb02753.x
1951:10.1111/j.1423-0410.1981.tb01053.x
1881:10.1111/j.1432-1033.1987.tb13478.x
1796:10.1111/j.1432-1033.1984.tb07910.x
1704:10.1111/j.1423-0410.1966.tb04226.x
1612:10.1111/j.1423-0410.1995.tb03924.x
1481:10.1111/j.1423-0410.1984.tb00102.x
1438:10.1111/j.1744-313X.1979.tb00693.x
1426:European Journal of Immunogenetics
897:which in humans is encoded by the
800:
771:
747:
718:
696:
677:
653:
634:
610:
591:
411:
372:
310:
289:
14:
3738:
3252:Huang CH, Blumenfeld OO (1991).
3217:Huang CH, Blumenfeld OO (1991).
3015:10.1046/j.1537-2995.2002.00093.x
2928:Blumenfeld OO, Huang CH (1996).
2667:10.1128/JVI.78.18.9807-9813.2004
2180:10.1111/j.1537-2995.2009.02480.x
429:
422:
415:
220:
213:
207:
182:
27:
2823:10.1128/JVI.66.9.5582-5585.1992
1256:virus (via its capsid), bovine
1243:erythrocyte binding antigen 175
3038:Tomita M, Marchesi VT (1976).
2706:. 79. 79 ( Pt 9) (9): 2163β9.
499:integral component of membrane
440:More reference expression data
395:More reference expression data
1:
3645:Siebert PD, Fukuda M (1987).
3592:Siebert PD, Fukuda M (1986).
3271:10.1016/S0021-9258(20)89637-9
3236:10.1182/blood.V77.8.1813.1813
3172:10.1016/S0021-9258(19)50736-0
3102:10.1016/S0021-9258(18)42569-0
2985:10.1016/s1246-7820(97)80041-9
2805:Svensson L (September 1992).
2575:Bull Soc Pathol Exot Filiales
2081:10.1182/blood.V77.8.1813.1813
2040:10.1182/blood.V80.9.2379.2379
1999:10.1016/S0021-9258(20)89637-9
997:s: 89% Caucasoid; 93% Negroid
994:S: 55% Caucasoid; 31% Negroid
991:N: 72% Caucasoid; 75% Negroid
205:
3650:Proc. Natl. Acad. Sci. U.S.A
3598:Proc. Natl. Acad. Sci. U.S.A
3433:10.1016/0378-1119(89)90080-2
3372:Proc. Natl. Acad. Sci. U.S.A
3287:Hamid J, Burness AT (1990).
3202:10.1016/0167-4781(91)90115-3
3044:Proc. Natl. Acad. Sci. U.S.A
2903:10.1016/0042-6822(87)90351-5
2784:10.1016/0005-2736(93)90170-5
1916:10.1515/bchm3.1989.370.2.855
1072:-Serine-Threonine-Threonine-
954:. GypB can be found only in
5868:Clusters of differentiation
5863:Genes on human chromosome 4
3851:clusters of differentiation
3796:Cartoon of glycophorin A -
3477:Tate CG, Tanner MJ (1988).
3137:10.1182/blood.V80.1.257.257
2713:10.1099/0022-1317-79-9-2163
1752:10.1182/blood.V80.1.257.257
5884:
1278:encephalomyocarditis virus
1218:residue with a glutamate.
910:cluster of differentiation
525:viral entry into host cell
3733:
3366:Kudo S, Fukuda M (1989).
1334:"Human PubMed Reference:"
1127:The incidence of Mi-I in
1058:-Serine-Threonine-Serine-
950:GypA can be found in all
872:
867:
863:
856:
837:
826:Chr 4: 144.11 β 144.14 Mb
820:
807:
778:
767:
754:
725:
714:
703:
699:
684:
680:
671:
660:
656:
641:
637:
628:
617:
613:
598:
594:
585:
570:
563:
559:
543:
473:identical protein binding
458:
454:
437:
414:
405:
392:
379:
375:
322:
313:
283:
275:
271:
254:
241:
204:
181:
172:
168:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
3791:Medical Subject Headings
1904:Biol. Chem. Hoppe-Seyler
3779:(Glycophorin-A) at the
3671:10.1073/pnas.84.19.6735
3393:10.1073/pnas.86.12.4619
2947:10.1002/humu.1380060302
1231:Relevance for infection
1159:
478:virus receptor activity
3619:10.1073/pnas.83.6.1665
3304:10.1093/nar/18.19.5829
3190:Biochim. Biophys. Acta
3057:10.1073/pnas.72.8.2964
2772:Biochim. Biophys. Acta
1659:10.1136/bmj.2.4829.175
1087:Miltenberger subsystem
50:Human UniProt search:
2618:10.1083/jcb.116.4.901
1238:Plasmodium falciparum
1007:Transfusion medicine
198:Chromosome 4 (human)
67:List of PDB id codes
40:Available structures
3787:GYPA+protein,+human
3662:1987PNAS...84.6735S
3610:1986PNAS...83.1665S
3384:1989PNAS...86.4619K
2868:10.1021/bi00499a016
535:leukocyte migration
354:ganglionic eminence
3808:, which is in the
3534:10.1007/BF00283724
3343:10.1007/BF01025303
1568:10.1007/BF00319639
1524:10.1007/BF00320913
1394:10.1007/BF00499143
1065:while Henshaw has
1002:Molecular medicine
518:Biological process
492:Cellular component
466:Molecular function
5850:
5849:
3756:
3755:
3495:10.1042/bj2540743
3292:Nucleic Acids Res
2749:10.1021/bi9606152
2542:10.1042/bj2090273
1836:10.1042/bj2130399
962:Molecular biology
880:
879:
876:
875:
852:
851:
816:
815:
797:
796:
763:
762:
744:
743:
710:
709:
693:
692:
667:
666:
650:
649:
624:
623:
607:
606:
555:
554:
450:
449:
446:
445:
401:
400:
388:
387:
369:
368:
334:bone marrow cells
267:
266:
102:
101:
98:
97:
5875:
3840:
3833:
3826:
3817:
3742:
3722:
3715:
3708:
3699:
3693:
3683:
3673:
3641:
3631:
3621:
3588:
3578:
3553:
3516:
3506:
3473:
3444:
3415:
3405:
3395:
3362:
3325:
3315:
3283:
3273:
3248:
3238:
3213:
3184:
3174:
3149:
3139:
3114:
3104:
3079:
3069:
3059:
3034:
2996:
2967:
2949:
2915:
2914:
2886:
2880:
2879:
2862:(47): 10684β90.
2851:
2845:
2844:
2834:
2802:
2796:
2795:
2767:
2761:
2760:
2732:
2726:
2725:
2715:
2695:
2689:
2688:
2678:
2646:
2640:
2639:
2629:
2597:
2591:
2590:
2570:
2564:
2563:
2553:
2521:
2515:
2514:
2478:
2472:
2471:
2435:
2429:
2428:
2391:
2382:
2381:
2345:
2339:
2338:
2302:
2296:
2295:
2259:
2253:
2252:
2216:
2210:
2206:
2200:
2199:
2163:
2157:
2156:
2143:
2137:
2136:
2100:
2094:
2093:
2083:
2059:
2053:
2052:
2042:
2018:
2012:
2011:
2001:
1977:
1971:
1970:
1934:
1928:
1927:
1899:
1893:
1892:
1864:
1858:
1857:
1847:
1815:
1809:
1808:
1798:
1774:
1765:
1764:
1754:
1730:
1724:
1723:
1687:
1681:
1680:
1670:
1638:
1632:
1631:
1594:
1588:
1587:
1550:
1544:
1543:
1507:
1501:
1500:
1464:
1458:
1457:
1420:
1414:
1413:
1377:
1371:
1365:
1359:
1358:
1351:
1342:
1341:
1330:
1324:
1314:
889:, also known as
865:
864:
848:
833:
828:
811:
801:
792:
772:
768:RefSeq (protein)
758:
748:
739:
719:
697:
678:
654:
635:
611:
592:
561:
456:
442:
433:
426:
419:
412:
397:
373:
318:
316:Top expressed in
311:
290:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
162:GYPA - orthologs
123:
116:
93:
64:
58:
37:
36:
31:
19:
5883:
5882:
5878:
5877:
5876:
5874:
5873:
5872:
5853:
5852:
5851:
5846:
5650:
5444:
5193:
4877:
4600:
4260:
3858:
3844:
3762:
3757:
3752:
3749:
3743:
3729:
3726:
3696:
3644:
3591:
3563:Eur. J. Biochem
3556:
3519:
3476:
3450:Eur. J. Biochem
3447:
3418:
3378:(12): 4619β23.
3365:
3331:J. Protein Chem
3328:
3298:(19): 5829β36.
3286:
3264:(11): 7248β55.
3251:
3216:
3187:
3152:
3117:
3082:
3037:
2999:
2970:
2927:
2923:
2921:Further reading
2918:
2888:
2887:
2883:
2853:
2852:
2848:
2804:
2803:
2799:
2769:
2768:
2764:
2734:
2733:
2729:
2697:
2696:
2692:
2661:(18): 9807β13.
2648:
2647:
2643:
2599:
2598:
2594:
2572:
2571:
2567:
2523:
2522:
2518:
2480:
2479:
2475:
2437:
2436:
2432:
2393:
2392:
2385:
2347:
2346:
2342:
2304:
2303:
2299:
2261:
2260:
2256:
2218:
2217:
2213:
2207:
2203:
2165:
2164:
2160:
2155:(Suppl 1): 174.
2145:
2144:
2140:
2102:
2101:
2097:
2061:
2060:
2056:
2020:
2019:
2015:
1992:(11): 7248β55.
1979:
1978:
1974:
1936:
1935:
1931:
1901:
1900:
1896:
1869:Eur. J. Biochem
1866:
1865:
1861:
1817:
1816:
1812:
1783:Eur. J. Biochem
1776:
1775:
1768:
1732:
1731:
1727:
1689:
1688:
1684:
1653:(4829): 175β7.
1640:
1639:
1635:
1596:
1595:
1591:
1552:
1551:
1547:
1509:
1508:
1504:
1466:
1465:
1461:
1422:
1421:
1417:
1388:(3β4): 333β48.
1379:
1378:
1374:
1366:
1362:
1353:
1352:
1345:
1332:
1331:
1327:
1315:
1306:
1302:
1290:
1233:
1224:
1212:
1202:residue with a
1196:
1188:
1180:
1171:
1162:
1160:Stone's antigen
1110:
1099:
1089:
1078:
1071:
1064:
1057:
1049:
1047:Henshaw antigen
1040:
1032:
1018:anti-N lectin.
1009:
1004:
972:
964:
934:
918:
885:MNS blood group
883:Glycophorin A (
869:View/Edit Human
846:
831:
824:
821:Location (UCSC)
809:
788:
784:
780:
756:
735:
731:
727:
644:ENSG00000170180
539:
513:
504:plasma membrane
487:
483:protein binding
438:
428:
427:
421:
420:
393:
384:
365:
360:
356:
352:
350:Achilles tendon
348:
344:
340:
336:
332:
328:
326:trabecular bone
314:
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
132:
119:
112:
73:
51:
17:
12:
11:
5:
5881:
5879:
5871:
5870:
5865:
5855:
5854:
5848:
5847:
5845:
5844:
5839:
5834:
5829:
5824:
5819:
5814:
5809:
5804:
5799:
5794:
5789:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5658:
5656:
5652:
5651:
5649:
5648:
5643:
5638:
5633:
5628:
5623:
5618:
5613:
5608:
5603:
5598:
5593:
5588:
5583:
5578:
5573:
5568:
5563:
5558:
5553:
5548:
5543:
5538:
5533:
5528:
5523:
5518:
5513:
5508:
5503:
5498:
5493:
5488:
5483:
5478:
5473:
5468:
5463:
5458:
5452:
5450:
5446:
5445:
5443:
5442:
5437:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5382:
5381:
5376:
5366:
5361:
5356:
5351:
5346:
5341:
5336:
5331:
5326:
5321:
5316:
5311:
5306:
5301:
5295:
5286:
5281:
5280:
5279:
5274:
5264:
5259:
5258:
5257:
5252:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5207:
5201:
5199:
5195:
5194:
5192:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5106:
5105:
5104:
5099:
5089:
5084:
5079:
5074:
5073:
5072:
5067:
5062:
5052:
5047:
5042:
5037:
5032:
5031:
5030:
5025:
5015:
5010:
5005:
5000:
4995:
4990:
4985:
4984:
4983:
4978:
4968:
4962:
4957:
4952:
4947:
4938:
4933:
4932:
4931:
4926:
4921:
4911:
4906:
4901:
4896:
4891:
4885:
4883:
4879:
4878:
4876:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4760:
4755:
4750:
4749:
4748:
4743:
4733:
4732:
4731:
4726:
4716:
4711:
4706:
4701:
4696:
4691:
4686:
4681:
4676:
4671:
4666:
4661:
4656:
4655:
4654:
4649:
4639:
4634:
4629:
4624:
4619:
4614:
4608:
4606:
4602:
4601:
4599:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4549:
4544:
4539:
4534:
4529:
4524:
4523:
4522:
4517:
4512:
4507:
4502:
4497:
4487:
4482:
4477:
4472:
4467:
4462:
4461:
4460:
4455:
4445:
4440:
4435:
4430:
4425:
4420:
4415:
4410:
4405:
4404:
4403:
4398:
4393:
4388:
4383:
4378:
4368:
4367:
4366:
4361:
4356:
4346:
4341:
4340:
4339:
4334:
4329:
4319:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4268:
4266:
4262:
4261:
4259:
4258:
4253:
4252:
4251:
4246:
4241:
4236:
4231:
4226:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4185:
4184:
4179:
4174:
4169:
4159:
4154:
4149:
4144:
4139:
4134:
4129:
4124:
4119:
4114:
4113:
4112:
4107:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4027:
4026:
4025:
4020:
4010:
4005:
4000:
3995:
3994:
3993:
3988:
3983:
3978:
3968:
3963:
3958:
3957:
3956:
3946:
3941:
3936:
3931:
3926:
3925:
3924:
3919:
3914:
3904:
3899:
3898:
3897:
3892:
3887:
3882:
3877:
3866:
3864:
3860:
3859:
3845:
3843:
3842:
3835:
3828:
3820:
3801:
3800:
3794:
3784:
3761:
3760:External links
3758:
3754:
3753:
3751:
3750:
3744:
3737:
3734:
3731:
3730:
3727:
3725:
3724:
3717:
3710:
3702:
3695:
3694:
3656:(19): 6735β9.
3642:
3589:
3554:
3517:
3474:
3445:
3416:
3363:
3326:
3284:
3249:
3229:(8): 1813β20.
3214:
3185:
3165:(5): 3336β42.
3150:
3115:
3095:(11): 7683β9.
3080:
3035:
2997:
2968:
2940:(3): 199β209.
2924:
2922:
2919:
2917:
2916:
2881:
2846:
2797:
2762:
2743:(29): 9513β8.
2727:
2690:
2641:
2592:
2565:
2516:
2473:
2430:
2383:
2340:
2297:
2254:
2211:
2201:
2174:(3): 635β641.
2158:
2138:
2095:
2074:(8): 1813β20.
2054:
2033:(9): 2379β87.
2013:
1972:
1945:(5β6): 302β5.
1929:
1894:
1859:
1830:(2): 399β404.
1810:
1766:
1725:
1682:
1633:
1589:
1545:
1502:
1459:
1415:
1382:Biochem. Genet
1372:
1360:
1343:
1325:
1303:
1301:
1298:
1297:
1296:
1289:
1286:
1232:
1229:
1223:
1220:
1211:
1208:
1195:
1192:
1187:
1184:
1179:
1178:Orriss antigen
1176:
1170:
1167:
1161:
1158:
1108:
1097:
1088:
1085:
1076:
1069:
1062:
1055:
1048:
1045:
1039:
1036:
1031:
1028:
1015:Vicia graminea
1008:
1005:
1003:
1000:
999:
998:
995:
992:
989:
971:
968:
963:
960:
933:
930:
917:
914:
878:
877:
874:
873:
871:
861:
860:
854:
853:
850:
849:
844:
842:
835:
834:
829:
822:
818:
817:
814:
813:
805:
804:
798:
795:
794:
776:
775:
769:
765:
764:
761:
760:
752:
751:
745:
742:
741:
723:
722:
716:
712:
711:
708:
707:
701:
700:
694:
691:
690:
682:
681:
675:
669:
668:
665:
664:
658:
657:
651:
648:
647:
639:
638:
632:
626:
625:
622:
621:
615:
614:
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605:
604:
596:
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583:
582:
577:
572:
568:
567:
557:
556:
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541:
540:
538:
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532:
527:
521:
519:
515:
514:
512:
511:
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501:
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493:
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486:
485:
480:
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469:
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463:
462:
452:
451:
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409:
403:
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399:
398:
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389:
386:
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370:
367:
366:
364:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
320:
319:
307:
306:
298:
287:
281:
280:
277:RNA expression
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5880:
5869:
5866:
5864:
5861:
5860:
5858:
5843:
5840:
5838:
5835:
5833:
5830:
5828:
5825:
5823:
5820:
5818:
5815:
5813:
5810:
5808:
5805:
5803:
5800:
5798:
5795:
5793:
5790:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5659:
5657:
5653:
5647:
5644:
5642:
5639:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5612:
5609:
5607:
5604:
5602:
5599:
5597:
5594:
5592:
5589:
5587:
5584:
5582:
5579:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5557:
5554:
5552:
5549:
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5539:
5537:
5534:
5532:
5529:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
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5499:
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5394:
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5389:
5387:
5384:
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5377:
5375:
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5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5103:
5100:
5098:
5095:
5094:
5093:
5090:
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5083:
5080:
5078:
5075:
5071:
5068:
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5063:
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5041:
5038:
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5033:
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5026:
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5021:
5020:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4982:
4979:
4977:
4974:
4973:
4972:
4969:
4966:
4963:
4961:
4958:
4956:
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4951:
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4907:
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4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4747:
4744:
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4739:
4738:
4737:
4734:
4730:
4727:
4725:
4722:
4721:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4653:
4650:
4648:
4645:
4644:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4609:
4607:
4603:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4553:
4550:
4548:
4545:
4543:
4540:
4538:
4535:
4533:
4530:
4528:
4525:
4521:
4518:
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4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4492:
4491:
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4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4459:
4456:
4454:
4451:
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4449:
4446:
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4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4373:
4372:
4369:
4365:
4362:
4360:
4357:
4355:
4352:
4351:
4350:
4347:
4345:
4342:
4338:
4335:
4333:
4330:
4328:
4325:
4324:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4269:
4267:
4263:
4257:
4254:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4221:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4183:
4180:
4178:
4175:
4173:
4170:
4168:
4165:
4164:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4111:
4108:
4106:
4103:
4102:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4024:
4021:
4019:
4016:
4015:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3973:
3972:
3969:
3967:
3964:
3962:
3959:
3955:
3952:
3951:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3923:
3920:
3918:
3915:
3913:
3910:
3909:
3908:
3905:
3903:
3900:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3872:
3871:
3868:
3867:
3865:
3861:
3856:
3852:
3848:
3841:
3836:
3834:
3829:
3827:
3822:
3821:
3818:
3814:
3813:
3811:
3810:public domain
3807:
3799:
3795:
3792:
3788:
3785:
3782:
3778:
3777:
3772:
3768:
3764:
3763:
3759:
3747:
3741:
3736:
3732:
3723:
3718:
3716:
3711:
3709:
3704:
3703:
3700:
3691:
3687:
3682:
3677:
3672:
3667:
3663:
3659:
3655:
3651:
3648:
3643:
3639:
3635:
3630:
3625:
3620:
3615:
3611:
3607:
3604:(6): 1665β9.
3603:
3599:
3595:
3590:
3586:
3582:
3577:
3572:
3569:(1): 147β53.
3568:
3564:
3560:
3555:
3551:
3547:
3543:
3539:
3535:
3531:
3527:
3523:
3518:
3514:
3510:
3505:
3500:
3496:
3492:
3489:(3): 743β50.
3488:
3484:
3480:
3475:
3471:
3467:
3463:
3459:
3456:(2): 337β44.
3455:
3451:
3446:
3442:
3438:
3434:
3430:
3427:(2): 325β32.
3426:
3422:
3417:
3413:
3409:
3404:
3399:
3394:
3389:
3385:
3381:
3377:
3373:
3369:
3364:
3360:
3356:
3352:
3348:
3344:
3340:
3337:(2): 129β36.
3336:
3332:
3327:
3323:
3319:
3314:
3309:
3305:
3301:
3297:
3293:
3290:
3285:
3281:
3277:
3272:
3267:
3263:
3259:
3258:J. Biol. Chem
3255:
3250:
3246:
3242:
3237:
3232:
3228:
3224:
3220:
3215:
3211:
3207:
3203:
3199:
3195:
3191:
3186:
3182:
3178:
3173:
3168:
3164:
3160:
3159:J. Biol. Chem
3156:
3151:
3147:
3143:
3138:
3133:
3130:(1): 257β63.
3129:
3125:
3121:
3116:
3112:
3108:
3103:
3098:
3094:
3090:
3089:J. Biol. Chem
3086:
3081:
3077:
3073:
3068:
3063:
3058:
3053:
3050:(8): 2964β8.
3049:
3045:
3041:
3036:
3032:
3028:
3024:
3020:
3016:
3012:
3009:(5): 567β71.
3008:
3004:
2998:
2994:
2990:
2986:
2982:
2979:(4): 357β65.
2978:
2974:
2969:
2965:
2961:
2957:
2953:
2948:
2943:
2939:
2935:
2931:
2926:
2925:
2920:
2912:
2908:
2904:
2900:
2897:(1): 94β101.
2896:
2892:
2885:
2882:
2877:
2873:
2869:
2865:
2861:
2857:
2850:
2847:
2842:
2838:
2833:
2828:
2824:
2820:
2817:(9): 5582β5.
2816:
2812:
2808:
2801:
2798:
2793:
2789:
2785:
2781:
2777:
2773:
2766:
2763:
2758:
2754:
2750:
2746:
2742:
2738:
2731:
2728:
2723:
2719:
2714:
2709:
2705:
2704:J. Gen. Virol
2701:
2694:
2691:
2686:
2682:
2677:
2672:
2668:
2664:
2660:
2656:
2652:
2645:
2642:
2637:
2633:
2628:
2623:
2619:
2615:
2611:
2607:
2603:
2596:
2593:
2588:
2584:
2580:
2576:
2569:
2566:
2561:
2557:
2552:
2547:
2543:
2539:
2535:
2531:
2527:
2520:
2517:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2484:
2477:
2474:
2469:
2465:
2461:
2457:
2453:
2449:
2446:(4): 318β21.
2445:
2441:
2434:
2431:
2426:
2422:
2418:
2414:
2410:
2406:
2402:
2398:
2390:
2388:
2384:
2379:
2375:
2371:
2367:
2363:
2359:
2356:(3): 237β41.
2355:
2351:
2344:
2341:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2308:
2301:
2298:
2293:
2289:
2285:
2281:
2277:
2273:
2269:
2265:
2258:
2255:
2250:
2246:
2242:
2238:
2234:
2230:
2227:(3): 238β41.
2226:
2222:
2215:
2212:
2205:
2202:
2197:
2193:
2189:
2185:
2181:
2177:
2173:
2169:
2162:
2159:
2154:
2150:
2149:Vox Sanguinis
2142:
2139:
2134:
2130:
2126:
2122:
2118:
2114:
2110:
2106:
2099:
2096:
2091:
2087:
2082:
2077:
2073:
2069:
2065:
2058:
2055:
2050:
2046:
2041:
2036:
2032:
2028:
2024:
2017:
2014:
2009:
2005:
2000:
1995:
1991:
1987:
1986:J. Biol. Chem
1983:
1976:
1973:
1968:
1964:
1960:
1956:
1952:
1948:
1944:
1940:
1933:
1930:
1925:
1921:
1917:
1913:
1909:
1905:
1898:
1895:
1890:
1886:
1882:
1878:
1874:
1870:
1863:
1860:
1855:
1851:
1846:
1841:
1837:
1833:
1829:
1825:
1821:
1814:
1811:
1806:
1802:
1797:
1792:
1789:(2): 259β65.
1788:
1784:
1780:
1773:
1771:
1767:
1762:
1758:
1753:
1748:
1745:(1): 257β63.
1744:
1740:
1736:
1729:
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1698:(2): 219β22.
1697:
1693:
1686:
1683:
1678:
1674:
1669:
1664:
1660:
1656:
1652:
1648:
1644:
1637:
1634:
1629:
1625:
1621:
1617:
1613:
1609:
1605:
1601:
1593:
1590:
1585:
1581:
1577:
1573:
1569:
1565:
1561:
1557:
1549:
1546:
1541:
1537:
1533:
1529:
1525:
1521:
1518:(5): 247β53.
1517:
1513:
1506:
1503:
1498:
1494:
1490:
1486:
1482:
1478:
1475:(6): 377β86.
1474:
1470:
1463:
1460:
1455:
1451:
1447:
1443:
1439:
1435:
1432:(6): 383β90.
1431:
1427:
1419:
1416:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1376:
1373:
1370:
1364:
1361:
1356:
1350:
1348:
1344:
1339:
1335:
1329:
1326:
1322:
1318:
1313:
1311:
1309:
1305:
1299:
1295:
1292:
1291:
1287:
1285:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1250:
1248:
1247:P. falciparum
1244:
1240:
1239:
1230:
1228:
1221:
1219:
1217:
1209:
1207:
1205:
1201:
1193:
1191:
1185:
1183:
1177:
1175:
1168:
1166:
1157:
1155:
1150:
1148:
1144:
1139:
1137:
1132:
1130:
1125:
1123:
1118:
1114:
1107:
1103:
1093:
1086:
1084:
1082:
1075:
1068:
1061:
1054:
1046:
1044:
1038:Dantu antigen
1037:
1035:
1029:
1027:
1025:
1019:
1017:
1016:
1006:
1001:
996:
993:
990:
988:
984:
980:
979:
978:
975:
969:
967:
961:
959:
957:
953:
948:
946:
945:
938:
931:
929:
927:
923:
915:
913:
911:
907:
903:
900:
896:
892:
888:
886:
870:
866:
862:
859:
855:
845:
843:
840:
836:
830:
827:
823:
819:
812:
806:
802:
799:
793:
791:
787:
783:
777:
773:
770:
766:
759:
753:
749:
746:
740:
738:
734:
730:
724:
720:
717:
715:RefSeq (mRNA)
713:
706:
702:
698:
695:
689:
688:
683:
679:
676:
674:
670:
663:
659:
655:
652:
646:
645:
640:
636:
633:
631:
627:
620:
616:
612:
609:
603:
602:
597:
593:
590:
588:
584:
581:
578:
576:
573:
569:
566:
562:
558:
551:
547:
542:
536:
533:
531:
530:viral process
528:
526:
523:
522:
520:
517:
516:
510:
507:
505:
502:
500:
497:
496:
494:
491:
490:
484:
481:
479:
476:
474:
471:
470:
468:
465:
464:
461:
460:Gene ontology
457:
453:
441:
436:
432:
425:
418:
413:
410:
408:
404:
396:
391:
381:
378:
374:
371:
361:
358:apex of heart
357:
353:
349:
345:
341:
337:
333:
329:
325:
324:
321:
317:
312:
309:
308:
305:
303:
299:
297:
296:
292:
291:
288:
286:
282:
278:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
5368:
5288:
5266:
5244:
5091:
5054:
5017:
4970:
4940:
4913:
4735:
4641:
4489:
4218:
3970:
3803:
3802:
3774:
3745:
3653:
3649:
3601:
3597:
3566:
3562:
3528:(1): 26β30.
3525:
3521:
3486:
3482:
3453:
3449:
3424:
3420:
3375:
3371:
3334:
3330:
3295:
3291:
3261:
3257:
3226:
3222:
3196:(2): 265β6.
3193:
3189:
3162:
3158:
3127:
3123:
3092:
3088:
3047:
3043:
3006:
3002:
2976:
2972:
2937:
2933:
2894:
2890:
2884:
2859:
2856:Biochemistry
2855:
2849:
2814:
2810:
2800:
2778:(1): 133β8.
2775:
2771:
2765:
2740:
2737:Biochemistry
2736:
2730:
2703:
2693:
2658:
2654:
2644:
2612:(4): 901β9.
2609:
2606:J. Cell Biol
2605:
2595:
2581:(5): 463β9.
2578:
2574:
2568:
2536:(1): 273β6.
2533:
2529:
2519:
2486:
2482:
2476:
2443:
2439:
2433:
2403:(5): 555β9.
2400:
2396:
2353:
2349:
2343:
2313:(4): 330β4.
2310:
2306:
2300:
2270:(2): 130β6.
2267:
2263:
2257:
2224:
2220:
2214:
2204:
2171:
2167:
2161:
2152:
2148:
2141:
2111:(2): 152β5.
2108:
2104:
2098:
2071:
2067:
2057:
2030:
2026:
2016:
1989:
1985:
1975:
1942:
1938:
1932:
1910:(8): 855β9.
1907:
1903:
1897:
1875:(1): 27β30.
1872:
1868:
1862:
1827:
1823:
1813:
1786:
1782:
1742:
1738:
1728:
1695:
1691:
1685:
1650:
1646:
1636:
1606:(3): 183β6.
1603:
1599:
1592:
1562:(1): 33β43.
1559:
1555:
1548:
1515:
1511:
1505:
1472:
1468:
1462:
1429:
1425:
1418:
1385:
1381:
1375:
1363:
1337:
1328:
1262:Sendai virus
1251:
1246:
1236:
1234:
1225:
1213:
1197:
1189:
1181:
1172:
1163:
1151:
1140:
1133:
1126:
1094:
1090:
1050:
1041:
1033:
1030:Null mutants
1020:
1013:
1010:
976:
973:
970:Blood groups
965:
949:
942:
939:
935:
926:blood groups
919:
905:
898:
890:
882:
881:
808:
786:NP_001295119
782:NP_001295116
779:
755:
733:NM_001308190
729:NM_001308187
726:
704:
685:
661:
642:
618:
599:
579:
574:
300:
293:
259:144,140,751
246:144,109,303
129:External IDs
72:
3728:PDB gallery
3003:Transfusion
2489:(1): 86β9.
2483:Transfusion
2397:Transfusion
2221:Transfusion
2168:Transfusion
1294:Glycophorin
1266:influenza A
1254:hepatitis A
1169:Sat antigen
1024:Chimpanzees
330:bone marrow
107:Identifiers
5857:Categories
3853:(see also
3522:Hum. Genet
3483:Biochem. J
2934:Hum. Mutat
2530:Biochem. J
1824:Biochem. J
1323:, May 2017
1300:References
1282:reoviruses
1272:, group C
1258:parvovirus
1210:Ny antigen
1194:Os antigen
1186:Mg antigen
1106:asparagine
1096:asparagine
1053:Tryptophan
304:(ortholog)
142:HomoloGene
1274:rotavirus
1222:Reactions
1216:aspartate
1147:Taiwanese
1136:kodecytes
1131:is 9.7%.
1074:Glutamate
1012:bind the
983:Caucasoid
790:NP_002090
737:NM_002099
565:Orthologs
150:GeneCards
3847:Proteins
3550:23151179
3031:34052803
3023:12084164
2964:34245274
2891:Virology
2811:J. Virol
2685:15331714
2655:J. Virol
2511:39840648
2468:33092281
2440:Vox Sang
2417:10827258
2378:83905143
2350:Vox Sang
2335:36810910
2307:Vox Sang
2292:24337520
2264:Vox Sang
2249:38287351
2196:20952307
2188:19912581
2105:Vox Sang
1967:27162982
1939:Vox Sang
1692:Vox Sang
1677:13059432
1647:Br Med J
1600:Vox Sang
1584:10130228
1540:21559983
1497:10869726
1469:Vox Sang
1454:21109436
1410:23990336
1319:–
1288:See also
1143:Japanese
1129:Thailand
1122:arginine
1117:tyrosine
1113:arginine
956:gorillas
952:primates
932:Genomics
916:Function
858:Wikidata
544:Sources:
509:membrane
342:monocyte
338:testicle
5655:301β350
5449:251β300
5401:CD240CE
5198:201β250
4882:151β200
4605:101β150
3781:PDBe-KB
3771:UniProt
3690:3477806
3658:Bibcode
3638:3456608
3606:Bibcode
3585:3345758
3542:3198123
3513:3196288
3504:1135146
3470:2792104
3441:2753361
3412:2734312
3380:Bibcode
3359:2911581
3351:2386609
3322:2216775
3280:2016325
3245:2015404
3210:1932122
3181:1737789
3146:1611092
3111:1560003
3076:1059087
2993:9269716
2956:8535438
2911:3604060
2876:2176879
2841:1380096
2792:8499461
2757:8755731
2722:9747725
2636:1310320
2627:2289329
2587:6370471
2560:6342608
2551:1154085
2503:7466911
2460:2442890
2425:6891686
2370:8036795
2327:2442891
2284:1722368
2241:8146897
2209:203-204
2133:7483916
2125:1114793
2090:2015404
2049:1421409
2008:2016325
1959:6172902
1924:2590469
1889:2439339
1854:6615443
1845:1152141
1805:6697986
1761:1611092
1712:5955790
1668:2028931
1628:2642482
1620:7625076
1576:3607294
1532:2470445
1489:6431691
1402:6860297
1321:Ensembl
1200:proline
1154:Denmark
1067:Leucine
1060:Glycine
987:Negroid
981:M: 78%
912:235a).
895:protein
893:, is a
673:UniProt
630:Ensembl
571:Species
550:QuickGO
279:pattern
238:4q31.21
114:Aliases
5662:CD300A
5621:CDw293
5406:CD240D
5267:CD213a
5245:CDw210
5210:CD202b
5184:CDw199
5179:CDw198
4833:CD140b
4265:51β100
3793:(MeSH)
3776:P02724
3688:
3681:299158
3678:
3636:
3629:323144
3626:
3583:
3548:
3540:
3511:
3501:
3468:
3439:
3410:
3403:287322
3400:
3357:
3349:
3320:
3313:332322
3310:
3278:
3243:
3208:
3179:
3144:
3109:
3074:
3067:432899
3064:
3029:
3021:
2991:
2962:
2954:
2909:
2874:
2839:
2832:289118
2829:
2790:
2755:
2720:
2683:
2676:514964
2673:
2634:
2624:
2585:
2558:
2548:
2509:
2501:
2466:
2458:
2423:
2415:
2376:
2368:
2333:
2325:
2290:
2282:
2247:
2239:
2194:
2186:
2131:
2123:
2088:
2047:
2006:
1965:
1957:
1922:
1887:
1852:
1842:
1803:
1759:
1718:
1710:
1675:
1665:
1626:
1618:
1582:
1574:
1538:
1530:
1495:
1487:
1452:
1446:521666
1444:
1408:
1400:
1204:serine
1102:lysine
985:; 74%
906:CD235a
841:search
839:PubMed
687:P02724
587:Entrez
407:BioGPS
362:spleen
138:617922
5842:CD350
5837:CD349
5832:CD344
5827:CD340
5822:CD339
5817:CD338
5812:CD337
5807:CD336
5802:CD335
5797:CD334
5792:CD333
5787:CD332
5782:CD331
5777:CD329
5772:CD328
5767:CD327
5762:CD326
5757:CD325
5752:CD324
5747:CD322
5742:CD321
5737:CD320
5732:CD318
5727:CD317
5722:CD316
5717:CD315
5712:CD314
5707:CD312
5702:CD309
5697:CD307
5692:CD306
5687:CD305
5682:CD304
5677:CD303
5672:CD302
5667:CD301
5646:CD299
5641:CD298
5636:CD297
5631:CD295
5626:CD294
5616:CD292
5611:CD290
5606:CD289
5601:CD288
5596:CD286
5591:CD284
5586:CD283
5581:CD282
5576:CD281
5571:CD280
5566:CD279
5561:CD278
5556:CD276
5551:CD275
5546:CD274
5541:CD273
5536:CD272
5531:CD271
5526:CD269
5521:CD268
5516:CD267
5511:CD266
5506:CD265
5501:CD264
5496:CD263
5491:CD262
5486:CD261
5481:CD258
5476:CD257
5471:CD256
5466:CD254
5461:CD253
5456:CD252
5440:CD249
5435:CD248
5431:CD247
5426:CD246
5421:CD244
5416:CD243
5411:CD241
5396:CD239
5391:CD238
5386:CD236
5369:CD235
5364:CD234
5359:CD233
5354:CD230
5349:CD229
5344:CD228
5339:CD227
5334:CD226
5329:CD225
5324:CD224
5319:CD223
5314:CD222
5309:CD221
5304:CD220
5289:CD218
5284:CD217
5262:CD212
5240:CD209
5235:CD208
5230:CD207
5225:CD206
5220:CD205
5215:CD204
5205:CD201
5189:CD200
5174:CD197
5169:CD196
5164:CD195
5159:CD194
5154:CD193
5149:CD192
5144:CD191
5139:CD186
5134:CD185
5129:CD184
5124:CD183
5119:CD182
5114:CD181
5109:CD180
5092:CD179
5087:CD178
5082:CD177
5077:CD174
5055:CD172
5050:CD171
5045:CD170
5040:CD169
5035:CD168
5018:CD167
5013:CD166
5008:CD164
5003:CD163
4998:CD162
4993:CD161
4988:CD160
4971:CD159
4941:CD158
4936:CD157
4914:CD156
4909:CD155
4904:CD154
4899:CD153
4894:CD152
4889:CD151
4873:CD150
4868:CD148
4863:CD147
4858:CD146
4853:CD144
4848:CD143
4843:CD142
4838:CD141
4828:CD138
4823:CD137
4818:CD136
4813:CD135
4808:CD134
4803:CD133
4798:CD132
4793:CD131
4788:CD130
4783:CD129
4778:CD127
4773:CD126
4768:CD125
4763:CD124
4758:CD123
4753:CD122
4736:CD121
4719:CD120
4714:CD119
4709:CD118
4704:CD117
4699:CD116
4694:CD115
4689:CD114
4684:CD113
4679:CD112
4674:CD111
4669:CD110
4664:CD109
4659:CD108
4642:CD107
4637:CD106
4632:CD105
4627:CD104
4622:CD103
4617:CD102
4612:CD101
4596:CD100
3546:S2CID
3355:S2CID
3223:Blood
3124:Blood
3027:S2CID
2960:S2CID
2507:S2CID
2464:S2CID
2421:S2CID
2374:S2CID
2331:S2CID
2288:S2CID
2245:S2CID
2192:S2CID
2129:S2CID
2068:Blood
2027:Blood
1963:S2CID
1739:Blood
1720:93107
1716:S2CID
1624:S2CID
1580:S2CID
1536:S2CID
1493:S2CID
1450:S2CID
1406:S2CID
1081:Natal
580:Mouse
575:Human
546:Amigo
346:blood
302:Mouse
295:Human
242:Start
175:Human
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