442:
31:
4052:
683:
Biotech, Inc.) which also markets the product in the United States. Janssen markets golimumab in Canada, Central and South
America, the Middle East, Africa and Asia Pacific. In the European Union, Russia, and Turkey, golimumab distribution rights are held by MSD (Ireland), a subsidiary of Merck &
661:
Golimumab binds to both soluble and transmembrane forms of TNFα. The antibody was isolated from a hybridoma clone produced by transgenic mice immunized with human TNFα. The golimumab-secreting clone was selected after being assayed for human light and heavy chains and TNFα-binding. The commercial
1407:
Tosh J, Archer R, Davis S, Stevenson M, Stevens JW (August 2013). "Golimumab for the treatment of rheumatoid arthritis after the failure of previous disease-modifying antirheumatic drugs: a NICE single technology appraisal".
1334:
261:
1451:
Williams VL, Cohen PR (May 2011). "TNF alpha antagonist-induced lupus-like syndrome: report and review of the literature with implications for treatment with alternative TNF alpha antagonists".
2997:
1168:
4102:
216:
512:
1185:
1066:
706:
4072:
1342:
610:. Golimumab was approved for the treatment by the US Food and Drug Administration (FDA) as well as the European Medicines Agency (EMA) in 2013 for the treatment of
1067:"Simponi (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis"
114:
1555:
4082:
2990:
4087:
709:(NICE) stated that treatment with golimumab is recommended for RA patients who have failed prior TNFi treatment. Unlike other TNFi treatments such as
57:
2471:
991:"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update"
942:"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update"
2983:
1142:
4006:
1043:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
705:
was more effective than methotrexate alone. When clinically indicated, golimumab is estimated as a moderate cost-effective treatment option.
617:
Golimumab is approved in Canada and the United States as a once monthly subcutaneous treatment for adults with moderately to severely active
583:
1172:
919:
1364:
Oldfield V, Plosker GL (2009). "Golimumab: in the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis".
572:
2414:
1784:
642:
1169:"Health Canada Approves Simponi (Golimumab) For Treatment Of Rheumatoid Arthritis, Psoriatic Arthritis And Ankylosing Spondylitis"
1548:
855:
829:
2823:
246:
146:
4097:
3978:
1494:
Rifkin LM, Birnbaum AD, Goldstein DA (August 2013). "TNF inhibition for ophthalmic indications: current status and outlook".
575:(VEGF) demonstrates golimumab as an effective modulator of inflammatory markers and bone metabolism. Golimumab is given via
626:
4042:
3988:
1620:
370:
4023:
1729:
1541:
698:
548:
165:
1197:
1599:
3572:
2277:
1038:
893:
684:
Co., Inc. In Japan, Indonesia, and Taiwan, distribution rights are held by
Mitsubishi Tanabe Pharma Corporation.
595:
4077:
2657:
650:
4092:
4011:
2652:
202:
437:
2457:
1883:
1564:
630:
607:
576:
544:
419:
209:
1335:"Simponi Receives European Commission Approval For Treatment Of Non-Radiographic Axial Spondyloarthritis"
796:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
3084:
3006:
2644:
3288:
1533:
795:
618:
599:
1865:
1233:
Maxwell LJ, Zochling J, Boonen A, Singh JA, Veras MM, Tanjong
Ghogomu E, et al. (April 2015).
1146:
622:
603:
540:
314:
67:
50:
3473:
3432:
3272:
3064:
2814:
1915:
1519:
1476:
1433:
1389:
1202:
714:
611:
556:
176:
39:. The heavy and light chain fragments are coloured blue and yellow, respectively. From PDB entry
2854:
2712:
2864:
2550:
1991:
989:
Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. (March 2014).
940:
Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. (March 2014).
916:
3364:
3034:
2975:
2819:
2809:
1610:
1568:
1511:
1468:
1425:
1381:
1316:
1254:
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1020:
971:
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747:
274:
96:
36:
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2181:
2077:
1503:
1460:
1417:
1373:
1306:
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1246:
1211:
1114:
1104:
1046:
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1002:
961:
953:
888:
767:
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454:
323:
379:
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2914:
2799:
1207:
923:
676:
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441:
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2154:
2133:
2129:
2125:
1753:
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1311:
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941:
772:
680:
4066:
3927:
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3673:
3598:
3558:
3478:
3372:
3018:
3010:
2954:
2884:
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2701:
2487:
2187:
2109:
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2041:
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1815:
1666:
1632:
1464:
1393:
1377:
560:
552:
430:
287:
138:
1480:
1437:
1006:
957:
701:
in patients with rheumatoid arthritis have shown that golimumab in combination with
3917:
3902:
3882:
3872:
3851:
3767:
3708:
3693:
3663:
3643:
3638:
3613:
3593:
3588:
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3533:
3523:
3513:
3463:
3458:
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3382:
3267:
3251:
3154:
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3139:
3114:
3054:
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2620:
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2192:
2139:
2016:
2006:
1825:
1742:
1737:
1695:
1648:
1605:
1572:
1250:
702:
229:
224:
1523:
662:
product is produced in a recombinant cell line cultured by continuous perfusion.
124:
3983:
3973:
3912:
3897:
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3877:
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3841:
3826:
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3744:
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3703:
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3683:
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3628:
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3309:
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3215:
3205:
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2331:
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2312:
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2293:
2273:
2226:
2202:
2160:
2144:
2115:
2099:
2067:
2051:
2046:
2021:
1971:
1961:
1956:
1951:
1940:
1930:
1835:
1747:
1705:
1690:
1684:
1680:
1627:
717:, there have been no reported cases of drug-induced lupus-like syndrome (DILS).
132:
3943:
3922:
3907:
3892:
3836:
3831:
3811:
3806:
3777:
3751:
3688:
3668:
3653:
3633:
3623:
3578:
3528:
3518:
3493:
3488:
3483:
3448:
3443:
3412:
3397:
3339:
3329:
3324:
3304:
3241:
3236:
3225:
3195:
3190:
3134:
3109:
3094:
3079:
3074:
3044:
2949:
2944:
2929:
2869:
2859:
2844:
2839:
2834:
2784:
2774:
2764:
2729:
2707:
2693:
2605:
2595:
2585:
2575:
2560:
2503:
2498:
2477:
2392:
2387:
2345:
2339:
2240:
2197:
2093:
2083:
2036:
2026:
2001:
1996:
1986:
1981:
1976:
1966:
1925:
1910:
1905:
1889:
1830:
1810:
1759:
1719:
1700:
1642:
1507:
1421:
710:
493:
354:
3846:
3678:
3503:
3402:
3387:
3246:
3210:
3200:
3174:
3169:
3149:
3124:
3104:
3099:
3069:
3039:
2939:
2934:
2919:
2894:
2849:
2829:
2789:
2724:
2688:
2610:
2406:
2359:
2288:
2254:
2221:
2031:
2011:
1820:
1660:
118:
41:
30:
1515:
1472:
1429:
1385:
1320:
1258:
1128:
1024:
975:
781:
1302:
917:
Statement On A Nonproprietary Name
Adopted By The USAN Council – Golimumab
763:
22:
3256:
3179:
3089:
3059:
2874:
2749:
2438:
1946:
1856:
1792:
1714:
1272:
334:
160:
1051:
343:
3733:
3618:
2367:
1109:
726:
84:
79:
725:
There is preliminary evidence for golimumab as a treatment option for
3958:
2682:
2513:
564:
410:
399:
2381:
2234:
1234:
537:
72:
2353:
2301:
2262:
2248:
1802:
1676:
568:
390:
296:
268:
2979:
1537:
281:
155:
2210:
803:
598:(EMA) has approved the use of golimumab as a treatment for
255:
187:
1143:"Johnson & Johnson Reports 2008 First-Quarter Results"
641:
The most common adverse reactions (incidence >5%) are
551:(TNF-alpha), a pro-inflammatory molecule and hence is a
584:
519:
4040:
1091:
Löwenberg M, de Boer NK, Hoentjen F (12 March 2014).
3966:
3956:
3936:
3865:
3799:
3790:
3759:
3431:
3363:
3297:
3026:
3017:
2742:
2670:
2643:
2528:
2171:
1873:
1864:
1855:
1848:
1801:
1783:
1774:
1728:
1659:
1589:
1580:
1093:"Golimumab for the treatment of ulcerative colitis"
824:
822:
820:
492:
453:
448:
429:
409:
389:
369:
353:
333:
313:
308:
245:
240:
215:
201:
175:
145:
131:
113:
105:
95:
90:
78:
66:
56:
49:
35:Cartoon representation of the antibody golimumab's
707:National Institutes for Health and Care Excellence
1235:"TNF-alpha inhibitors for ankylosing spondylitis"
1198:"FDA clears potential blockbuster arthritis drug"
322:
883:
881:
879:
877:
4103:World Health Organization essential medicines
2991:
1549:
8:
164:
21:
1239:The Cochrane Database of Systematic Reviews
3963:
3796:
3023:
2998:
2984:
2976:
1870:
1861:
1852:
1780:
1586:
1556:
1542:
1534:
1097:Clinical and Experimental Gastroenterology
440:
29:
1310:
1118:
1108:
1050:
1014:
965:
771:
378:
4073:Drugs developed by Johnson & Johnson
830:"Simponi- golimumab injection, solution"
4047:
738:
342:
137:
431:
20:
1271:
1045:. Geneva: World Health Organization.
563:, intercellaular adhesion molecules (
418:
123:
7:
1453:International Journal of Dermatology
228:
398:
4088:Drugs developed by Merck & Co.
4083:Drugs developed by Schering-Plough
856:"Simponi Aria- golimumab solution"
573:vascular endothelial growth factor
14:
1273:FDA Professional Drug Information
643:upper respiratory tract infection
4050:
1465:10.1111/j.1365-4632.2011.04871.x
1378:10.2165/00063030-200923020-00005
1285:Mazumdar S, Greenwald D (2009).
995:Annals of the Rheumatic Diseases
946:Annals of the Rheumatic Diseases
746:Mazumdar S, Greenwald D (2009).
471:
465:
1341:(Press release). Archived from
1007:10.1136/annrheumdis-2013-204573
958:10.1136/annrheumdis-2013-204573
1251:10.1002/14651858.CD005468.pub2
483:
477:
459:
1:
627:juvenile idiopathic arthritis
1621:dihydroorotate dehydrogenase
928:American Medical Association
699:randomized controlled trials
567:1, matrix metalloproteinase
545:immunosuppressive medication
532:, sold under the brand name
1600:purine synthesis inhibitors
675:Golimumab was developed by
549:tumor necrosis factor alpha
4119:
1055:. WHO/MHP/HPS/EML/2023.02.
559:(CRP) levels, interleukin
449:Chemical and physical data
4001:
1785:IL-1 receptor antagonists
1508:10.1007/s40259-013-0022-9
1422:10.1007/s40273-013-0052-7
1039:World Health Organization
894:European Medicines Agency
596:European Medicines Agency
509:
28:
2658:Anti-lymphocyte globulin
922:20 February 2012 at the
651:injection site reactions
555:. Profound reduction in
2653:Anti-thymocyte globulin
1565:Immunosuppressive drugs
2458:Interleukin-6 receptor
1884:Complement component 5
631:ankylosing spondylitis
608:ankylosing spondylitis
577:subcutaneous injection
210:Subcutaneous injection
4098:Monoclonal antibodies
3085:Camidanlumab tesirine
3007:Monoclonal antibodies
1339:Johnson & Johnson
1303:10.4161/mabs.1.5.9286
764:10.4161/mabs.1.5.9286
101:Simponi, Simponi Aria
3760:Chimeric + humanized
3289:Nivolumab/relatlimab
1186:FDA Approves Simponi
697:Large, double-blind
693:Rheumatoid arthritis
619:rheumatoid arthritis
600:rheumatoid arthritis
547:. Golimumab targets
543:which is used as an
1175:on 2 February 2010.
898:. 17 September 2018
836:. 30 September 2019
727:ocular inflammation
666:Society and culture
623:psoriatic arthritis
604:psoriatic arthritis
541:monoclonal antibody
277:(Prescription only)
264:(Prescription only)
51:Monoclonal antibody
25:
16:Pharmaceutical drug
4028:Never to phase III
3474:Certolizumab pegol
3441:Immunosuppressive:
2815:Diroximel fumarate
2488:IL-2 receptor/CD25
1916:Certolizumab pegol
1569:Immunosuppressants
1203:North County Times
1110:10.2147/CEG.S48741
715:certolizumab pegol
612:ulcerative colitis
557:C-reactive protein
4038:
4037:
3997:
3996:
3952:
3951:
3786:
3785:
3741:Immune activation
3233:Immune activation
3035:Immunosuppression
2973:
2972:
2820:Efgartigimod alfa
2810:Dimethyl fumarate
2738:
2737:
2666:
2665:
2639:
2638:
1844:
1843:
1770:
1769:
1611:Mycophenolic acid
1410:PharmacoEconomics
1149:on 7 October 2008
679:, Inc. (formerly
527:
526:
300:
285:
272:
259:
191:
158:
37:variable fragment
4110:
4055:
4054:
4053:
4046:
3964:
3797:
3355:Zolimomab aritox
3345:Telimomab aritox
3024:
3000:
2993:
2986:
2977:
2616:Telimomab aritox
2519:Zolimomab aritox
2340:CD62L/L-selectin
2078:Immunoglobulin E
1871:
1862:
1853:
1781:
1587:
1558:
1551:
1544:
1535:
1528:
1527:
1491:
1485:
1484:
1448:
1442:
1441:
1404:
1398:
1397:
1361:
1355:
1354:
1352:
1350:
1331:
1325:
1324:
1314:
1282:
1276:
1275:
1269:
1263:
1262:
1230:
1224:
1223:
1221:
1219:
1212:Associated Press
1194:
1188:
1183:
1177:
1176:
1171:. Archived from
1165:
1159:
1158:
1156:
1154:
1145:. Archived from
1139:
1133:
1132:
1122:
1112:
1088:
1082:
1081:
1079:
1077:
1063:
1057:
1056:
1054:
1035:
1029:
1028:
1018:
986:
980:
979:
969:
937:
931:
914:
908:
907:
905:
903:
885:
872:
871:
869:
867:
862:. 2 October 2020
852:
846:
845:
843:
841:
826:
815:
814:
812:
810:
800:nctr-crs.fda.gov
792:
786:
785:
775:
743:
523:
522:
515:
504:
502:
485:
479:
473:
467:
461:
444:
433:
422:
402:
382:
346:
326:
298:
295:
290:
283:
280:
270:
267:
257:
254:
232:
189:
186:
168:
157:
154:
141:
127:
44:
33:
26:
24:
4118:
4117:
4113:
4112:
4111:
4109:
4108:
4107:
4078:Janssen Biotech
4063:
4062:
4061:
4051:
4049:
4041:
4039:
4034:
4033:
4018:Clinical trials
3993:
3948:
3932:
3861:
3782:
3773:Rozanolixizumab
3761:
3755:
3747:
3736:
3549:Lulizumab pegol
3427:
3359:
3293:
3013:
3004:
2974:
2969:
2915:Rozanolixizumab
2800:Deucravacitinib
2734:
2662:
2635:
2524:
2173:
2167:
1875:
1840:
1797:
1776:
1766:
1724:
1664:
1655:
1591:Antimetabolites
1582:
1576:
1562:
1532:
1531:
1493:
1492:
1488:
1450:
1449:
1445:
1406:
1405:
1401:
1363:
1362:
1358:
1348:
1346:
1333:
1332:
1328:
1284:
1283:
1279:
1270:
1266:
1245:(4): CD005468.
1232:
1231:
1227:
1217:
1215:
1214:. 24 April 2009
1208:Lee Enterprises
1196:
1195:
1191:
1184:
1180:
1167:
1166:
1162:
1152:
1150:
1141:
1140:
1136:
1090:
1089:
1085:
1075:
1073:
1065:
1064:
1060:
1037:
1036:
1032:
988:
987:
983:
939:
938:
934:
924:Wayback Machine
915:
911:
901:
899:
887:
886:
875:
865:
863:
854:
853:
849:
839:
837:
828:
827:
818:
808:
806:
794:
793:
789:
745:
744:
740:
735:
723:
695:
690:
677:Janssen Biotech
673:
668:
659:
647:nasopharyngitis
639:
637:Adverse effects
592:
518:
516:
513:(what is this?)
510:
500:
498:
488:
482:
476:
470:
464:
425:
405:
385:
365:
349:
329:
304:
288:
236:
204:
197:
178:
171:
45:
40:
17:
12:
11:
5:
4116:
4114:
4106:
4105:
4100:
4095:
4093:TNF inhibitors
4090:
4085:
4080:
4075:
4065:
4064:
4060:
4059:
4036:
4035:
4032:
4031:
4030:
4029:
4026:
4015:
4009:
4003:
4002:
3999:
3998:
3995:
3994:
3992:
3991:
3986:
3981:
3976:
3970:
3968:
3961:
3954:
3953:
3950:
3949:
3947:
3946:
3940:
3938:
3934:
3933:
3931:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3869:
3867:
3863:
3862:
3860:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3803:
3801:
3794:
3788:
3787:
3784:
3783:
3781:
3780:
3775:
3770:
3764:
3762:
3757:
3756:
3738:
3737:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3573:+hyaluronidase
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3437:
3435:
3429:
3428:
3426:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3369:
3367:
3361:
3360:
3358:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3307:
3301:
3299:
3295:
3294:
3292:
3291:
3281:
3280:
3275:
3270:
3260:
3259:
3254:
3249:
3244:
3239:
3229:
3228:
3223:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3177:
3172:
3167:
3162:
3157:
3152:
3147:
3142:
3137:
3132:
3127:
3122:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3082:
3077:
3072:
3067:
3062:
3057:
3052:
3047:
3042:
3030:
3028:
3021:
3015:
3014:
3005:
3003:
3002:
2995:
2988:
2980:
2971:
2970:
2968:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2902:
2897:
2892:
2887:
2882:
2877:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2824:+hyaluronidase
2817:
2812:
2807:
2805:Deuruxolitinib
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2746:
2744:
2740:
2739:
2736:
2735:
2733:
2732:
2727:
2722:
2717:
2716:
2715:
2710:
2698:
2697:
2696:
2691:
2678:
2676:
2668:
2667:
2664:
2663:
2661:
2660:
2655:
2649:
2647:
2641:
2640:
2637:
2636:
2634:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2532:
2530:
2526:
2525:
2523:
2522:
2509:
2508:
2507:
2506:
2501:
2496:
2483:
2482:
2481:
2480:
2468:
2467:
2466:
2454:
2453:
2452:
2447:
2435:
2434:
2433:
2428:
2423:
2411:
2410:
2409:
2398:
2397:
2396:
2395:
2390:
2378:
2377:
2376:
2364:
2363:
2362:
2350:
2349:
2348:
2336:
2335:
2334:
2329:
2317:
2316:
2315:
2310:
2298:
2297:
2296:
2291:
2286:
2281:
2278:+hyaluronidase
2271:
2259:
2258:
2257:
2245:
2244:
2243:
2231:
2230:
2229:
2224:
2219:
2207:
2206:
2205:
2200:
2195:
2190:
2177:
2175:
2169:
2168:
2166:
2165:
2164:
2163:
2150:
2149:
2148:
2147:
2142:
2121:
2120:
2119:
2118:
2105:
2104:
2103:
2102:
2089:
2088:
2087:
2086:
2073:
2072:
2071:
2070:
2057:
2056:
2055:
2054:
2049:
2044:
2039:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1999:
1994:
1989:
1984:
1979:
1974:
1969:
1964:
1959:
1954:
1949:
1936:
1935:
1934:
1933:
1928:
1923:
1918:
1913:
1908:
1895:
1894:
1893:
1892:
1879:
1877:
1868:
1859:
1850:
1846:
1845:
1842:
1841:
1839:
1838:
1833:
1828:
1823:
1818:
1813:
1807:
1805:
1799:
1798:
1796:
1795:
1789:
1787:
1778:
1772:
1771:
1768:
1767:
1765:
1764:
1763:
1762:
1754:PDE4 inhibitor
1750:
1745:
1740:
1734:
1732:
1726:
1725:
1723:
1722:
1717:
1711:
1710:
1709:
1708:
1703:
1698:
1693:
1672:
1670:
1657:
1656:
1654:
1653:
1652:
1651:
1638:
1637:
1636:
1635:
1630:
1616:
1615:
1614:
1613:
1608:
1595:
1593:
1584:
1578:
1577:
1563:
1561:
1560:
1553:
1546:
1538:
1530:
1529:
1486:
1443:
1399:
1356:
1345:on 19 May 2016
1326:
1277:
1264:
1225:
1189:
1178:
1160:
1134:
1083:
1058:
1030:
1001:(3): 492–509.
981:
952:(3): 492–509.
932:
909:
889:"Simponi EPAR"
873:
847:
816:
787:
737:
736:
734:
731:
722:
719:
694:
691:
689:
686:
672:
669:
667:
664:
658:
655:
638:
635:
591:
588:
525:
524:
507:
506:
496:
490:
489:
486:
480:
474:
468:
462:
457:
451:
450:
446:
445:
435:
427:
426:
424:
423:
415:
413:
407:
406:
404:
403:
395:
393:
387:
386:
384:
383:
375:
373:
367:
366:
364:
363:
359:
357:
351:
350:
348:
347:
339:
337:
331:
330:
328:
327:
319:
317:
311:
310:
306:
305:
303:
302:
293:
278:
265:
251:
249:
243:
242:
238:
237:
235:
234:
221:
219:
213:
212:
207:
205:administration
199:
198:
196:
195:
193:
183:
181:
173:
172:
170:
169:
151:
149:
143:
142:
135:
129:
128:
121:
111:
110:
107:
103:
102:
99:
93:
92:
88:
87:
82:
76:
75:
70:
64:
63:
62:Whole antibody
60:
54:
53:
47:
46:
34:
15:
13:
10:
9:
6:
4:
3:
2:
4115:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4070:
4068:
4058:
4048:
4044:
4027:
4025:
4022:
4021:
4019:
4016:
4013:
4010:
4008:
4005:
4004:
4000:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3971:
3969:
3965:
3962:
3960:
3957:Inflammatory
3955:
3945:
3942:
3941:
3939:
3935:
3929:
3928:Tildrakizumab
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3870:
3868:
3864:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3804:
3802:
3798:
3795:
3793:
3789:
3779:
3776:
3774:
3771:
3769:
3766:
3765:
3763:
3758:
3754:
3753:
3750:
3746:
3742:
3735:
3732:
3730:
3729:Vobarilizumab
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3674:Spartalizumab
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3599:Pembrolizumab
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3574:
3570:
3567:
3565:
3562:
3560:
3559:Mogamulizumab
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3479:Crizanlizumab
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3439:
3438:
3436:
3434:
3430:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3373:Andecaliximab
3371:
3370:
3368:
3366:
3362:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3302:
3300:
3296:
3290:
3286:
3283:
3282:
3279:
3276:
3274:
3271:
3269:
3265:
3262:
3261:
3258:
3255:
3253:
3250:
3248:
3245:
3243:
3240:
3238:
3234:
3231:
3230:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3037:
3036:
3032:
3031:
3029:
3025:
3022:
3020:
3019:Immune system
3016:
3012:
3011:immune system
3008:
3001:
2996:
2994:
2989:
2987:
2982:
2981:
2978:
2966:
2963:
2961:
2958:
2956:
2955:Tildrakizumab
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2891:
2888:
2886:
2885:Pegcetacoplan
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2825:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2795:Darvadstrocel
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2747:
2745:
2741:
2731:
2728:
2726:
2723:
2721:
2718:
2714:
2711:
2709:
2706:
2705:
2704:
2703:
2702:TNF inhibitor
2699:
2695:
2692:
2690:
2687:
2686:
2685:
2684:
2680:
2679:
2677:
2674:
2669:
2659:
2656:
2654:
2651:
2650:
2648:
2646:
2642:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2533:
2531:
2527:
2520:
2516:
2515:
2511:
2510:
2505:
2502:
2500:
2497:
2495:
2492:
2491:
2490:
2489:
2485:
2484:
2479:
2476:
2475:
2474:
2473:
2469:
2465:
2462:
2461:
2460:
2459:
2455:
2451:
2448:
2446:
2443:
2442:
2441:
2440:
2436:
2432:
2429:
2427:
2424:
2422:
2419:
2418:
2417:
2416:
2412:
2408:
2405:
2404:
2403:
2400:
2399:
2394:
2391:
2389:
2386:
2385:
2384:
2383:
2379:
2375:
2372:
2371:
2370:
2369:
2368:CD147/Basigin
2365:
2361:
2358:
2357:
2356:
2355:
2351:
2347:
2344:
2343:
2342:
2341:
2337:
2333:
2330:
2328:
2325:
2324:
2323:
2322:
2318:
2314:
2311:
2309:
2306:
2305:
2304:
2303:
2299:
2295:
2292:
2290:
2287:
2285:
2282:
2279:
2275:
2272:
2270:
2267:
2266:
2265:
2264:
2260:
2256:
2253:
2252:
2251:
2250:
2246:
2242:
2239:
2238:
2237:
2236:
2232:
2228:
2225:
2223:
2220:
2218:
2215:
2214:
2213:
2212:
2208:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2188:Muromonab-CD3
2186:
2185:
2184:
2183:
2179:
2178:
2176:
2170:
2162:
2159:
2158:
2157:
2156:
2152:
2151:
2146:
2143:
2141:
2138:
2137:
2136:
2135:
2131:
2127:
2123:
2122:
2117:
2114:
2113:
2112:
2111:
2107:
2106:
2101:
2098:
2097:
2096:
2095:
2091:
2090:
2085:
2082:
2081:
2080:
2079:
2075:
2074:
2069:
2066:
2065:
2064:
2063:
2062:Interleukin 5
2059:
2058:
2053:
2050:
2048:
2045:
2043:
2042:Tildrakizumab
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1944:
1943:
1942:
1938:
1937:
1932:
1929:
1927:
1924:
1922:
1919:
1917:
1914:
1912:
1909:
1907:
1904:
1903:
1902:
1901:
1897:
1896:
1891:
1888:
1887:
1886:
1885:
1881:
1880:
1878:
1876:(noncellular)
1872:
1869:
1867:
1863:
1860:
1858:
1854:
1851:
1849:Extracellular
1847:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1816:Ridaforolimus
1814:
1812:
1809:
1808:
1806:
1804:
1800:
1794:
1791:
1790:
1788:
1786:
1782:
1779:
1775:Intracellular
1773:
1761:
1758:
1757:
1756:
1755:
1751:
1749:
1746:
1744:
1741:
1739:
1736:
1735:
1733:
1731:
1727:
1721:
1718:
1716:
1713:
1712:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1688:
1687:
1686:
1682:
1678:
1674:
1673:
1671:
1668:
1662:
1658:
1650:
1647:
1646:
1645:
1644:
1640:
1639:
1634:
1633:Teriflunomide
1631:
1629:
1626:
1625:
1623:
1622:
1618:
1617:
1612:
1609:
1607:
1604:
1603:
1602:
1601:
1597:
1596:
1594:
1592:
1588:
1585:
1581:Intracellular
1579:
1574:
1570:
1566:
1559:
1554:
1552:
1547:
1545:
1540:
1539:
1536:
1525:
1521:
1517:
1513:
1509:
1505:
1502:(4): 347–57.
1501:
1497:
1490:
1487:
1482:
1478:
1474:
1470:
1466:
1462:
1459:(5): 619–25.
1458:
1454:
1447:
1444:
1439:
1435:
1431:
1427:
1423:
1419:
1416:(8): 653–61.
1415:
1411:
1403:
1400:
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1391:
1387:
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1379:
1375:
1372:(2): 125–35.
1371:
1367:
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1336:
1330:
1327:
1322:
1318:
1313:
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1304:
1300:
1297:(5): 422–31.
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1268:
1265:
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1256:
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1126:
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1111:
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1102:
1098:
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1087:
1084:
1072:
1071:www.drugs.com
1068:
1062:
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1040:
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1008:
1004:
1000:
996:
992:
985:
982:
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973:
968:
963:
959:
955:
951:
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943:
936:
933:
929:
925:
921:
918:
913:
910:
897:
895:
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884:
882:
880:
878:
874:
861:
857:
851:
848:
835:
831:
825:
823:
821:
817:
805:
801:
797:
791:
788:
783:
779:
774:
769:
765:
761:
758:(5): 422–31.
757:
753:
749:
742:
739:
732:
730:
728:
720:
718:
716:
712:
708:
704:
700:
692:
687:
685:
682:
678:
670:
665:
663:
656:
654:
652:
648:
644:
636:
634:
632:
628:
624:
620:
615:
613:
609:
605:
601:
597:
589:
587:
585:
582:It is on the
580:
578:
574:
570:
566:
562:
558:
554:
553:TNF inhibitor
550:
546:
542:
539:
535:
531:
521:
514:
508:
497:
495:
491:
458:
456:
452:
447:
443:
439:
436:
434:
432:ECHA InfoCard
428:
421:
420:ChEMBL1201833
417:
416:
414:
412:
408:
401:
397:
396:
394:
392:
388:
381:
377:
376:
374:
372:
368:
361:
360:
358:
356:
352:
345:
341:
340:
338:
336:
332:
325:
321:
320:
318:
316:
312:
307:
301: Rx-only
294:
291:
279:
276:
266:
263:
253:
252:
250:
248:
244:
239:
231:
226:
223:
222:
220:
218:
214:
211:
208:
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194:
185:
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180:
174:
167:
162:
153:
152:
150:
148:
144:
140:
136:
134:
130:
126:
122:
120:
116:
112:
108:
104:
100:
98:
94:
91:Clinical data
89:
86:
83:
81:
77:
74:
71:
69:
65:
61:
59:
55:
52:
48:
43:
38:
32:
27:
19:
3918:Risankizumab
3903:Lebrikizumab
3883:Clazakizumab
3873:Anrukinzumab
3852:Tralokinumab
3768:Otelixizumab
3748:
3740:
3739:
3709:Tregalizumab
3694:Tislelizumab
3664:Satralizumab
3644:Rontalizumab
3639:Retifanlimab
3614:Plozalizumab
3594:Pateclizumab
3589:Pascolizumab
3584:Ozoralizumab
3534:Lampalizumab
3524:Inebilizumab
3514:Fontolizumab
3464:Camrelizumab
3459:Benralizumab
3454:Atezolizumab
3440:
3383:Clenoliximab
3284:
3268:Bertilimumab
3263:
3252:Tremelimumab
3232:
3155:Mavrilimumab
3145:Lirentelimab
3140:Lerdelimumab
3119:
3115:Fresolimumab
3055:Atorolimumab
3033:
2965:Upadacitinib
2925:Satralizumab
2910:Ritlecitinib
2905:Risankizumab
2700:
2681:
2621:Teprotumumab
2571:Inebilizumab
2566:Fontolizumab
2546:Atorolimumab
2514:T-lymphocyte
2512:
2486:
2470:
2456:
2437:
2426:Lerdelimumab
2421:Bertilimumab
2413:
2401:
2380:
2366:
2352:
2338:
2319:
2300:
2284:Pascolizumab
2269:Obinutuzumab
2261:
2247:
2233:
2217:Clenoliximab
2209:
2193:Otelixizumab
2180:
2153:
2140:Lebrikizumab
2124:
2108:
2092:
2076:
2060:
2017:Satralizumab
2007:Risankizumab
1939:
1920:
1898:
1882:
1874:Serum target
1826:Temsirolimus
1752:
1743:Pomalidomide
1738:Lenalidomide
1696:Pimecrolimus
1675:
1649:Methotrexate
1641:
1619:
1606:Azathioprine
1598:
1583:(initiation)
1499:
1495:
1489:
1456:
1452:
1446:
1413:
1409:
1402:
1369:
1365:
1359:
1347:. Retrieved
1343:the original
1338:
1329:
1294:
1290:
1280:
1267:
1242:
1238:
1228:
1216:. Retrieved
1201:
1192:
1181:
1173:the original
1163:
1151:. Retrieved
1147:the original
1137:
1100:
1096:
1086:
1074:. Retrieved
1070:
1061:
1052:10665/371090
1042:
1033:
998:
994:
984:
949:
945:
935:
927:
912:
900:. Retrieved
892:
864:. Retrieved
859:
850:
838:. Retrieved
833:
807:. Retrieved
799:
790:
755:
751:
741:
724:
703:methotrexate
696:
674:
671:Availability
660:
640:
616:
593:
590:Medical uses
581:
533:
529:
528:
517:
511:
247:Legal status
241:Legal status
147:License data
18:
4014:from market
3984:Lemalesomab
3979:Fanolesomab
3974:Besilesomab
3913:Perakizumab
3898:Mirikizumab
3888:Gevokizumab
3878:Bimekizumab
3857:Ustekinumab
3842:Secukinumab
3827:Fezakinumab
3822:Canakinumab
3817:Briakinumab
3792:Interleukin
3745:Dostarlimab
3724:Visilizumab
3719:Vedolizumab
3714:Vatelizumab
3704:Toralizumab
3699:Tocilizumab
3684:Teclistamab
3659:Samalizumab
3649:Rovelizumab
3629:Ravulizumab
3609:Pidilizumab
3604:Pexelizumab
3569:Ocrelizumab
3564:Natalizumab
3554:Mepolizumab
3544:Ligelizumab
3539:Letolizumab
3509:Etrolizumab
3499:Epratuzumab
3469:Cedelizumab
3423:Vapaliximab
3418:Teneliximab
3408:Lumiliximab
3393:Gomiliximab
3378:Basiliximab
3350:Vepalimomab
3335:Nerelimomab
3320:Gavilimomab
3315:Faralimomab
3310:Elsilimomab
3285:Combination
3278:Zanolimumab
3273:Ontamalimab
3221:Ulocuplumab
3216:Tezepelumab
3206:Sifalimumab
3186:Pamrevlumab
3165:Morolimumab
3160:Metelimumab
3130:Lanadelumab
3065:Avdoralimab
3050:Anifrolumab
2960:Tofacitinib
2900:Ravulizumab
2890:Pirfenidone
2880:Peficitinib
2780:Canakinumab
2770:Briakinumab
2760:Bimekizumab
2755:Baricitinib
2720:Aflibercept
2631:Vepalimomab
2626:Vapaliximab
2601:Rovelizumab
2591:Pexelizumab
2581:Morolimumab
2556:Cedelizumab
2541:Anifrolumab
2536:Alemtuzumab
2494:Basiliximab
2464:Tocilizumab
2450:Vedolizumab
2445:Natalizumab
2431:Metelimumab
2374:Gavilimomab
2332:Toralizumab
2327:Teneliximab
2313:Lumiliximab
2308:Gomiliximab
2294:Ublituximab
2274:Ocrelizumab
2227:Zanolimumab
2203:Visilizumab
2161:Secukinumab
2145:Ustekinumab
2116:Elsilimomab
2100:Faralimomab
2068:Mepolizumab
2052:Ustekinumab
2047:Tocilizumab
2022:Secukinumab
1972:Canakinumab
1962:Briakinumab
1957:Bimekizumab
1952:Basiliximab
1941:Interleukin
1931:Nerelimomab
1836:Zotarolimus
1777:(reception)
1748:Thalidomide
1706:Voclosporin
1691:Ciclosporin
1685:Calcineurin
1681:Cyclophilin
1628:Leflunomide
1624:inhibitors
1287:"Golimumab"
902:11 November
866:11 November
840:11 November
748:"Golimumab"
657:Development
505: g·mol
438:100.226.360
324:476181-74-5
309:Identifiers
133:MedlinePlus
106:Other names
97:Trade names
4067:Categories
3944:Lokivetmab
3937:Veterinary
3923:Spesolimab
3908:Olokizumab
3893:Ixekizumab
3837:Guselkumab
3832:Fletikumab
3812:Brazikumab
3807:Bermekimab
3778:Sutimlimab
3752:Ibalizumab
3689:Teplizumab
3669:Siplizumab
3654:Ruplizumab
3634:Reslizumab
3624:Quilizumab
3579:Omalizumab
3529:Itolizumab
3519:Frexalimab
3494:Efalizumab
3489:Eculizumab
3484:Daclizumab
3449:Aselizumab
3444:Apolizumab
3413:Priliximab
3398:Infliximab
3340:Odulimomab
3330:Maslimomab
3325:Inolimomab
3305:Afelimomab
3242:Durvalumab
3237:Ipilimumab
3226:Varlilumab
3196:Relatlimab
3191:Placulumab
3135:Lenzilumab
3110:Emapalumab
3095:Cemiplimab
3080:Brodalumab
3075:Bleselumab
3045:Adalimumab
2950:Sutimlimab
2945:Spesolimab
2930:Siltuximab
2870:Olokizumab
2860:Ixekizumab
2855:Itacitinib
2845:Guselkumab
2840:Fingolimod
2835:Filgotinib
2785:Crovalimab
2775:Brodalumab
2765:Blisibimod
2730:Rilonacept
2713:Opinercept
2708:Etanercept
2694:Belatacept
2645:Polyclonal
2606:Siplizumab
2596:Reslizumab
2586:Ofatumumab
2576:Maslimomab
2561:Emapalumab
2504:Inolimomab
2499:Daclizumab
2478:Odulimomab
2393:Ruplizumab
2388:Frexalimab
2346:Aselizumab
2241:Efalizumab
2198:Teplizumab
2094:Interferon
2084:Omalizumab
2037:Spesolimab
2027:Siltuximab
2002:Rilonacept
1997:Olokizumab
1987:Ixekizumab
1982:Guselkumab
1977:Daclizumab
1967:Brodalumab
1926:Infliximab
1911:Afelimomab
1906:Adalimumab
1890:Eculizumab
1866:Monoclonal
1857:Antibodies
1831:Umirolimus
1811:Everolimus
1760:Apremilast
1720:Gusperimus
1701:Tacrolimus
1669:inhibitors
1661:Macrolides
1643:antifolate
1218:23 October
809:22 October
733:References
711:adalimumab
494:Molar mass
380:91X1KLU43E
355:ChemSpider
315:CAS Number
4024:Phase III
4012:Withdrawn
3989:Sulesomab
3866:Humanized
3847:Sirukumab
3679:Talizumab
3504:Erlizumab
3433:Humanized
3403:Keliximab
3388:Galiximab
3247:Nivolumab
3211:Tabalumab
3201:Sarilumab
3175:Oleclumab
3170:Namilumab
3150:Lirilumab
3125:Ianalumab
3120:Golimumab
3105:Eldelumab
3100:Dupilumab
3070:Belimumab
3040:Abrilumab
2940:Sirukumab
2935:Siponimod
2920:Sarilumab
2895:Ponesimod
2865:Netakimab
2850:Iptacopan
2830:Etrasimod
2790:Danicopan
2725:Alefacept
2689:Abatacept
2611:Talizumab
2551:Begelomab
2407:Belimumab
2360:Galiximab
2289:Rituximab
2255:Erlizumab
2222:Keliximab
2032:Sirukumab
2012:Sarilumab
1992:Netakimab
1921:Golimumab
1821:Sirolimus
1394:195685167
530:Golimumab
203:Routes of
177:Pregnancy
166:Golimumab
125:Monograph
119:Drugs.com
23:Golimumab
4057:Medicine
3365:Chimeric
3257:Urelumab
3180:Oxelumab
3090:Carlumab
3060:Avelumab
3009:for the
2875:Ozanimod
2750:Avacopan
2743:Unsorted
2529:Unsorted
2439:Integrin
2172:Cellular
1947:Anakinra
1793:Anakinra
1715:Abetimus
1567: /
1516:23568177
1496:BioDrugs
1481:21538173
1473:21506984
1438:23085023
1430:23576019
1386:19489653
1366:BioDrugs
1321:20065639
1259:25887212
1153:28 April
1129:24648749
1103:: 53–9.
1041:(2023).
1025:24161836
976:24161836
920:Archived
860:DailyMed
834:DailyMed
782:20065639
688:Research
681:Centocor
520:(verify)
335:DrugBank
217:ATC code
179:category
161:DailyMed
109:CNTO-148
3959:lesions
3734:TGN1412
3619:PRO 140
2671:-cept (
1312:2759491
1120:3958527
1016:4079096
967:4079096
773:2759491
721:Uveitis
569:(MMP)-3
536:, is a
534:Simponi
455:Formula
344:DB06674
292:Rx-only
289:WARNING
233:)
227: (
225:L04AB06
192: C
163::
139:a610010
4043:Portal
4007:WHO-EM
3749:Other:
2683:CTLA-4
2673:Fusion
2174:target
2155:IL-17A
2132:, and
1665:other
1524:391892
1522:
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1479:
1471:
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649:, and
571:, and
565:ICAM)-
561:(IL)-6
411:ChEMBL
400:D04358
286:
273:
260:
159:
80:Target
68:Source
3967:Mouse
3800:Human
3298:Mouse
3264:Other
3027:Human
2472:LFA-1
2382:CD154
2235:CD11a
2134:IL-23
2130:IL-13
2126:IL-12
1730:IMiDs
1520:S2CID
1477:S2CID
1434:S2CID
1390:S2CID
1349:9 May
1076:9 May
896:(EMA)
538:human
469:10068
73:Human
2402:BLyS
2354:CD80
2321:CD40
2302:CD23
2263:CD20
2249:CD18
2110:IL-6
1803:mTOR
1677:FKBP
1667:IL-2
1512:PMID
1469:PMID
1426:PMID
1382:PMID
1351:2016
1317:PMID
1291:mAbs
1255:PMID
1220:2010
1155:2008
1125:PMID
1078:2016
1021:PMID
972:PMID
904:2020
868:2020
842:2020
811:2023
778:PMID
752:mAbs
713:and
629:and
606:and
594:The
481:2026
475:1752
463:6530
391:KEGG
371:UNII
362:none
115:AHFS
85:TNFα
58:Type
42:5yoy
2415:CAT
2211:CD4
2182:CD3
1900:TNF
1573:L04
1504:doi
1461:doi
1418:doi
1374:doi
1307:PMC
1299:doi
1247:doi
1115:PMC
1105:doi
1047:hdl
1011:PMC
1003:doi
962:PMC
954:doi
804:FDA
768:PMC
760:doi
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