338:
315:
3674:
212:
237:
3704:
49:
3719:
589:
344:
243:
3689:
3659:
5423:
1444:, allowing higher-intensity treatment regimens. It is administered to oncology patients via subcutaneous or intravenous routes. A QSP model of neutrophil production and a PK/PD model of a cytotoxic chemotherapeutic drug (Zalypsis) have been developed to optimize the use of G-CSF in chemotherapy regimens with the aim to prevent mild-neutropenia.
1655:(CHO cells). As this is a mammalian cell expression system, lenograstim is indistinguishable from the 174-amino acid natural human G-CSF. No clinical or therapeutic consequences of the differences between filgrastim and lenograstim have yet been identified, but there are no formal comparative studies.
3192:
Tweardy DJ, Cannizzaro LA, Palumbo AP, Shane S, Huebner K, Vantuinen P, et al. (August 1987). "Molecular cloning and characterization of a cDNA for human granulocyte colony-stimulating factor (G-CSF) from a glioblastoma multiforme cell line and localization of the G-CSF gene to chromosome band
75:
2301:
Szyper-Kravitz M, Uziel O, Shapiro H, Radnay J, Katz T, Rowe JM, et al. (January 2003). "Granulocyte colony-stimulating factor administration upregulates telomerase activity in CD34+ haematopoietic cells and may prevent telomere attrition after chemotherapy".
3518:
Haniu M, Horan T, Arakawa T, Le J, Katta V, Rohde MF (December 1995). "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region".
3427:
Watari K, Ozawa K, Tajika K, Tojo A, Tani K, Kamachi S, et al. (July 1994). "Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization".
3673:
3332:
Le Beau MM, Lemons RS, Carrino JJ, Pettenati MJ, Souza LM, Diaz MO, et al. (December 1987). "Chromosomal localization of the human G-CSF gene to 17q11 proximal to the breakpoint of the t(15;17) in acute promyelocytic leukemia".
2162:
Craig M, Humphries AR, Nekka F, Bélair J, Li J, Mackey MC (November 2015). "Neutrophil dynamics during concurrent chemotherapy and G-CSF administration: Mathematical modelling guides dose optimisation to minimise neutropenia".
3354:
Zink T, Ross A, Lüers K, Cieslar C, Rudolph R, Holak TA (July 1994). "Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein".
2993:
Sallerfors B, Olofsson T (October 1992). "Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by quantitative immunoassays".
3154:
Simmers RN, Smith J, Shannon MF, Wong G, Lopez AF, Baker E, et al. (February 1988). "Localization of the human G-CSF gene to the region of a breakpoint in the translocation typical of acute promyelocytic leukemia".
3548:
McCracken S, Layton JE, Shorter SC, Starkey PM, Barlow DH, Mardon HJ (May 1996). "Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta".
3294:
Kanda N, Fukushige S, Murotsu T, Yoshida MC, Tsuchiya M, Asano S, et al. (November 1987). "Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17".
2858:"Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury"
1344:
G-CSF can also act on neuronal cells as a neurotrophic factor. Indeed, its receptor is expressed by neurons in the brain and spinal cord. The action of G-CSF in the central nervous system is to induce
3703:
2569:
Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, et al. (April 1986). "Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells".
5468:
2386:
Lally J, Malik S, Krivoy A, Whiskey E, Taylor DM, Gaughran FP, et al. (October 2017). "The Use of
Granulocyte Colony-Stimulating Factor in Clozapine Rechallenge: A Systematic Review".
4568:
2206:
Morstyn G, Campbell L, Souza LM, Alton NK, Keech J, Green M, et al. (March 1988). "Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy".
2347:"Use of granulocyte-colony stimulating factor to prevent recurrent clozapine-induced neutropenia on drug rechallenge: A systematic review of the literature and clinical recommendations"
1447:
G-CSF was first trialled as a therapy for neutropenia induced by chemotherapy in 1988. The treatment was well tolerated and a dose-dependent rise in circulating neutrophils was noted.
4352:
2813:
Zhang Y, Wang L, Fu Y, Song H, Zhao H, Deng M, et al. (2009). "Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis".
2090:"The impact of the granulocyte colony-stimulating factor on chemotherapy dose intensity and cancer survival: a systematic review and meta-analysis of randomized controlled trials"
2037:
Nagata S, Tsuchiya M, Asano S, Kaziro Y, Yamazaki T, Yamamoto O, et al. (1986). "Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor".
3759:
3082:
Kubota N, Orita T, Hattori K, Oh-eda M, Ochi N, Yamazaki T (March 1990). "Structural characterization of natural and recombinant human granulocyte colony-stimulating factors".
1336:(HSC) mobilization from the bone marrow into the bloodstream, although it has been shown that it does not directly affect the hematopoietic progenitors that are mobilized.
2919:
Duarte RF, Frank DA (June 2002). "The synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): molecular basis and clinical relevance".
351:
250:
4584:
3964:
3803:
33:
5046:
4512:
1285:
4634:
1809:
Deotare U, Al-Dawsari G, Couban S, Lipton JH (September 2015). "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept".
5066:
1388:
3386:"Spontaneous production of granulocyte colony-stimulating factor in vitro by human B-lineage lymphocytes is a distinctive marker of germinal center cells"
4694:
4345:
3883:
3682:: STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN
2436:"Granulocyte-colony stimulating factor for hematopoietic stem cell donation from healthy female donors during pregnancy and lactation: what do we know?"
877:
3718:
858:
173:
3257:
Devlin JJ, Devlin PE, Myambo K, Lilly MB, Rado TA, Warren MK (April 1987). "Expression of granulocyte colony-stimulating factor by human cell lines".
5037:
5026:
5002:
4492:
3752:
1541:
1505:
1384:
The two polypeptides differ by the presence or absence of three amino acids. Expression studies indicate that both have authentic GCSF activity.
4381:
5443:
4338:
3638:
2730:
1791:
1773:
1621:. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim.
4660:
3814:
1893:
Thomas J, Liu F, Link DC (May 2002). "Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor".
1663:
G-CSF when given early after exposure to radiation may improve white blood cell counts, and is stockpiled for use in radiation incidents.
337:
4060:
3745:
4392:
1101:
1108:
314:
5346:
1485:
2475:
Paydaş S, Sahin B, Seyrek E, Soylu M, Gonlusen G, Acar A, et al. (September 1993). "Sweet's syndrome associated with G-CSF".
1313:
4307:
4278:
3688:
3658:
1760:
1739:
1569:
2614:"Press Announcements - FDA approves first biosimilar to Neulasta to help reduce the risk of infection during cancer treatment"
2137:
5057:
4759:
3876:
236:
211:
2748:"Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice"
1756:
72:
1696:
1670:
1317:
5413:
1735:
1632:. Several bio-generic versions are now also available in markets such as Europe and Australia. Filgrastim (Neupogen) and
1484:. G-CSF can restore neutrophil count. Following a return to baseline after stopping the drug, it may sometimes be safely
1356:. These properties are currently under investigations for the development of treatments of neurological diseases such as
5361:
153:
1273:. The more-abundant and more-active 174-amino acid form has been used in the development of pharmaceutical products by
1513:
1938:"The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis"
1436:, a recombinant form of G-CSF is used with certain cancer patients to accelerate recovery and reduce mortality from
350:
249:
5351:
4993:
1652:
1309:
5453:
4952:
4422:
4175:
3921:
3869:
3768:
3631:
3585:
1695:
in a clinical phase IIb and several clinical pilot studies are published for other neurological disease such as
1211:
343:
242:
3589:
1528:
of it from the milk. People who have been administered colony-stimulating factors do not have a higher risk of
1497:
1293:
922:
161:
3712:: THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS
5448:
4705:
4401:
4040:
2251:"Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner"
1333:
903:
4417:
2613:
5090:
3934:
1987:"Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis"
1685:
1301:
1234:
4902:
4897:
4848:
4217:
4045:
4036:
4027:
1545:
225:
4487:
4502:
5017:
4853:
4558:
4452:
4050:
3624:
3478:
3467:"The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors"
3216:"Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells"
3044:
2869:
2578:
2527:
2172:
2046:
1669:
planned in 2004 to use G-CSF to treat heart degeneration by injecting it into the blood-stream, plus
1525:
1451:
17:
5260:
140:
4968:
4858:
4750:
4467:
4462:
4457:
4447:
4170:
4055:
1637:
1557:
1219:
1055:
996:
4721:
4579:
4548:
3033:"Secondary structure of human granulocyte colony-stimulating factor derived from NMR spectroscopy"
2249:
Hirbe AC, Uluçkan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, et al. (April 2007).
2088:
Lyman GH, Dale DC, Culakova E, Poniewierski MS, Wolff DA, Kuderer NM, et al. (October 2013).
5463:
4882:
4877:
4843:
4838:
4784:
4599:
4372:
4364:
4273:
4251:
4229:
4084:
4079:
4032:
4023:
3453:
3415:
3320:
3282:
3180:
3070:
3019:
2981:
2944:
2838:
2551:
2500:
2411:
2327:
2231:
2070:
1918:
1834:
185:
5371:
4675:
4665:
4655:
4589:
4538:
1084:
1063:
1059:
1051:
1025:
1004:
1000:
992:
5300:
5290:
5280:
5217:
4942:
4645:
2856:
Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Sanberg PR, Sanchez-Ramos J, et al. (2014).
2633:"Acute radiation injury: contingency planning for triage, supportive care, and transplantation"
5310:
5295:
5212:
5177:
4922:
4427:
4361:
3596:
3566:
3536:
3506:
3445:
3407:
3372:
3342:
3312:
3274:
3245:
3202:
3172:
3142:
3113:"The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor"
3099:
3062:
3011:
2973:
2936:
2897:
2830:
2777:
2726:
2703:
2654:
2631:
Weisdorf D, Chao N, Waselenko JK, Dainiak N, Armitage JO, McNiece I, et al. (June 2006).
2594:
2543:
2492:
2457:
2403:
2368:
2319:
2280:
2223:
2188:
2119:
2062:
2016:
1967:
1910:
1875:
1826:
1692:
1357:
133:
65:
5237:
4412:
4963:
4892:
4887:
4775:
4432:
4312:
4297:
4091:
3981:
3558:
3528:
3496:
3486:
3437:
3397:
3364:
3304:
3266:
3235:
3227:
3164:
3132:
3124:
3091:
3052:
3003:
2965:
2928:
2887:
2877:
2822:
2767:
2759:
2693:
2685:
2644:
2586:
2535:
2484:
2447:
2395:
2358:
2311:
2270:
2262:
2215:
2180:
2109:
2101:
2054:
2006:
1998:
1957:
1949:
1936:
Schneider A, Krüger C, Steigleder T, Weber D, Pitzer C, Laage R, et al. (August 2005).
1902:
1865:
1818:
1517:
1409:
1405:
1321:
1215:
430:
361:
305:
260:
48:
4871:
2672:
Weinstock DM, Case C, Bader JL, Chao NJ, Coleman CN, Hatchett RJ, et al. (June 2008).
5341:
5318:
4863:
4780:
4543:
4073:
4017:
3948:
3892:
3095:
2796:"AXIS 2: AX200 for the Treatment of Ischemic Stroke - Full Text View - ClinicalTrials.gov"
1608:
1349:
1274:
588:
405:
181:
3384:
Corcione A, Baldi L, Zupo S, Dono M, Rinaldi GB, Roncella S, et al. (October 1994).
3111:
Nagata S, Tsuchiya M, Asano S, Yamamoto O, Hirata Y, Kubota N, et al. (March 1986).
1985:
Pitzer C, Krüger C, Plaas C, Kirsch F, Dittgen T, Müller R, et al. (December 2008).
1568:
Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in
1387:
It is thought that stability of the G-CSF mRNA is regulated by an RNA element called the
3482:
3048:
2873:
2746:
Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, et al. (September 2009).
2582:
2531:
2176:
2050:
5458:
5427:
5202:
5192:
5119:
4736:
4726:
4650:
4482:
4261:
4134:
3850:
3832:
3231:
3137:
3128:
3112:
3007:
2892:
2857:
2772:
2763:
2747:
2698:
2673:
2488:
2275:
2250:
2114:
2089:
2011:
1986:
1962:
1937:
1703:
cells has been shown to reduce impairment from chronic traumatic brain injury in rats.
3240:
3215:
2219:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
666:
661:
645:
640:
635:
630:
5437:
4770:
4553:
4472:
4109:
4012:
3952:
3939:
3784:
3605:
3501:
3466:
3057:
3032:
2315:
1906:
1633:
1585:
1521:
1501:
1481:
1477:
1370:
1258:
617:
3457:
3419:
3324:
3286:
3074:
3023:
2985:
2948:
2842:
2555:
2415:
2235:
1838:
1233:
G-CSF also stimulates the survival, proliferation, differentiation, and function of
165:
5376:
5356:
5275:
5265:
5207:
5154:
5084:
4983:
4927:
4614:
4604:
4594:
4497:
4477:
4442:
4437:
4317:
4285:
4246:
4139:
3974:
3969:
3896:
2674:"Radiologic and nuclear events: contingency planning for hematologists/oncologists"
2331:
2074:
1922:
1854:"Cellular players of hematopoietic stem cell mobilization in the bone marrow niche"
1681:
1677:
1441:
1345:
1180:
423:
202:
3184:
2504:
1691:
Due to its neuroprotective properties, G-CSF is currently under investigation for
2882:
2795:
2689:
2399:
2266:
1300:. G-CSF stimulates the survival, proliferation, differentiation, and function of
189:
5386:
5381:
5285:
5270:
5242:
5232:
5227:
5182:
5149:
5144:
5139:
5134:
5129:
5114:
5109:
4932:
4917:
4912:
4731:
4716:
4533:
4256:
4241:
4205:
4101:
3957:
3402:
3385:
2518:
Metcalf D (July 1985). "The granulocyte-macrophage colony-stimulating factors".
1796:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1778:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1648:
1469:
1437:
1425:
1378:
1297:
1289:
1270:
1250:
1227:
1196:
1188:
1184:
5422:
4330:
3471:
Proceedings of the
National Academy of Sciences of the United States of America
2649:
2632:
2184:
506:
5222:
5124:
4978:
4523:
4234:
4222:
4154:
4144:
4114:
3998:
3944:
2932:
2826:
1870:
1853:
1712:
1700:
1618:
1592:
1433:
1413:
1305:
1262:
1254:
1238:
1223:
322:
219:
169:
3737:
2956:
Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers".
2363:
2346:
5396:
5391:
5172:
4619:
4290:
4185:
4180:
4149:
3491:
3441:
2590:
2539:
2452:
2435:
2105:
1666:
1641:
1573:
1509:
1473:
1417:
1353:
1192:
822:
566:
444:
389:
376:
288:
275:
177:
3532:
2977:
2940:
2901:
2834:
2781:
2707:
2658:
2461:
2407:
2372:
2323:
2284:
2192:
2123:
2020:
2002:
1971:
1914:
1879:
1830:
3570:
3562:
3540:
3510:
3449:
3411:
3376:
3346:
3316:
3278:
3249:
3206:
3176:
3146:
3103:
3066:
3015:
2969:
2598:
2547:
2496:
2227:
2066:
1310:
Janus kinase (JAK)/signal transducer and activator of transcription (STAT)
1261:
cells. The natural human glycoprotein exists in two forms, a 174- and 177-
1148:
1143:
4624:
4266:
4210:
3986:
3912:
3861:
3776:
3270:
1629:
1529:
1458:
1429:
1203:
1132:
967:
948:
3368:
1822:
1524:
should be withheld for three days after CSF administration to allow for
1292:, and, in response to stimulation by G-CSF, initiates proliferation and
4302:
3842:
3610:
3600:
3308:
3168:
1613:
1581:
1266:
1207:
934:
889:
110:
106:
102:
98:
94:
5197:
5187:
4832:
4828:
4824:
4820:
4816:
4812:
3794:
2058:
1953:
1636:(Neulasta) are two commercially available forms of rhG-CSF. The PEG (
1421:
1381:
are synthesized from the same gene by differential splicing of mRNA.
1374:
1116:
844:
1373:, locus q11.2-q12. Nagata et al. found that the GCSF gene has four
4867:
4808:
4804:
4800:
4796:
4792:
4788:
4685:
3824:
3031:
Zink T, Ross A, Ambrosius D, Rudolph R, Holak TA (December 1992).
1625:
1596:
1577:
807:
803:
5252:
5164:
5101:
3727:: Crystal Structure of the Human GCSF-Receptor Signaling Complex
3214:
Tsuchiya M, Nomura H, Asano S, Kaziro Y, Nagata S (March 1987).
793:
positive regulation of DNA-binding transcription factor activity
157:
4334:
3865:
3741:
3620:
597:
3616:
2345:
Myles N, Myles H, Clark SR, Bird R, Siskind D (October 2017).
723:
positive regulation of phosphatidylinositol 3-kinase signaling
1684:
burden, and reverse cognitive impairment in a mouse model of
3595:
Overview of all the structural information available in the
743:
positive regulation of transcription by RNA polymerase II
738:
positive regulation of actin cytoskeleton reorganization
718:
positive regulation of peptidyl-tyrosine phosphorylation
413:
4493:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
1576:
in 1983, and the human form was cloned by groups from
698:
positive regulation of peptidyl-serine phosphorylation
646:
granulocyte colony-stimulating factor receptor binding
5411:
1673:(stromal cell-derived factor) directly to the heart.
1457:
G-CSF administration has been shown to attenuate the
578:
144:, C17orf33, CSF3OS, GCSF, colony stimulating factor 3
2351:
The
Australian and New Zealand Journal of Psychiatry
763:
positive regulation of cell population proliferation
688:
positive regulation of actin filament polymerization
5331:
5309:
5251:
5163:
5100:
5083:
5076:
5056:
5036:
5016:
4992:
4951:
4758:
4749:
4704:
4684:
4633:
4567:
4511:
4400:
4391:
4371:
4198:
4163:
4127:
4100:
3997:
3920:
3911:
3904:
3841:
3823:
3793:
3775:
2723:
Stem cells: controversy on the frontiers of science
1077:
1044:
1018:
985:
753:
positive regulation of myeloid cell differentiation
5469:Drugs acting on the blood and blood forming organs
1752:
1750:
1748:
1731:
1729:
1727:
1450:A study in mice has shown that G-CSF may decrease
683:positive regulation of protein kinase B signaling
360:
259:
4585:Granulocyte macrophage colony-stimulating factor
3804:Granulocyte macrophage colony-stimulating factor
1852:Tay J, Levesque JP, Winkler IG (February 2017).
1508:. For this purpose, G-CSF appears to be safe in
1222:analogs of naturally occurring G-CSF are called
34:granulocyte-macrophage colony-stimulating factor
3609:(Granulocyte colony-stimulating factor) at the
2296:
2294:
2138:"Granulocyte colony stimulating factor (G-CSF)"
1500:in the blood of the donor before collection by
3465:Hill CP, Osslund TD, Eisenberg D (June 1993).
2429:
2427:
2425:
2032:
2030:
1757:GRCm38: Ensembl release 89: ENSMUSG00000038067
1644:, reducing the necessity of daily injections.
4346:
3877:
3753:
3632:
1496:G-CSF is also used to increase the number of
8:
1389:G-CSF factor stem-loop destabilising element
2637:Biology of Blood and Marrow Transplantation
1736:GRCh38: Ensembl release 89: ENSG00000108342
1560:is a known side effect of using this drug.
1540:G-CSF may also be given to the receiver in
1214:, and is produced by a number of different
5352:Leukemia/leukocyte inhibitory factor (LIF)
5097:
5080:
4755:
4397:
4353:
4339:
4331:
3917:
3908:
3884:
3870:
3862:
3760:
3746:
3738:
3639:
3625:
3617:
2958:Clinical Chemistry and Laboratory Medicine
1269:of molecular weight 19,600 grams per
818:
613:
401:
300:
197:
83:
5347:FMS-like tyrosine kinase 3 ligand (FLT3L)
4776:Interferon alpha (interferon alfa, IFN-α)
3588:at the U.S. National Library of Medicine
3500:
3490:
3401:
3239:
3136:
3056:
2891:
2881:
2771:
2697:
2648:
2612:Office of the Commissioner (2019-09-11).
2451:
2362:
2274:
2113:
2010:
1961:
1869:
783:regulation of signaling receptor activity
5369:Additional cytokine receptor modulators:
3697:: 2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
3667:: 2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
1611:human G-CSF (rhG-CSF) synthesised in an
1595:of Neulasta in June 2018. It is made by
5418:
3654:
3521:Archives of Biochemistry and Biophysics
2434:Pessach I, Shimoni A, Nagler A (2013).
1723:
1542:hematopoietic stem cell transplantation
1506:hematopoietic stem cell transplantation
733:cellular response to lipopolysaccharide
5193:Cucurbitacin I (elatericin B, JSI-124)
2388:Journal of Clinical Psychopharmacology
728:positive regulation of protein binding
693:cellular response to cytokine stimulus
38:
4529:Granulocyte colony-stimulating factor
3810:Granulocyte colony-stimulating factor
3586:Granulocyte+Colony-Stimulating+Factor
3096:10.1093/oxfordjournals.jbchem.a123072
1942:The Journal of Clinical Investigation
1424:. G-CSF stimulates the production of
1288:is present on precursor cells in the
1161:Granulocyte colony-stimulating factor
365:
326:
321:
264:
223:
218:
18:Granulocyte colony stimulating factor
7:
4888:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
4661:Macrophage colony-stimulating factor
3815:Macrophage colony-stimulating factor
537:endothelial cell of lymphatic vessel
5362:Thymic stromal lymphopoietin (TSLP)
3297:Somatic Cell and Molecular Genetics
1858:International Journal of Hematology
1461:loss associated with chemotherapy.
788:cytokine-mediated signaling pathway
748:negative regulation of neuron death
3232:10.1002/j.1460-2075.1987.tb04798.x
3129:10.1002/j.1460-2075.1986.tb04249.x
3008:10.1111/j.1600-0609.1992.tb00047.x
2764:10.1016/j.neuroscience.2009.05.071
2489:10.1111/j.1365-2141.1993.tb08668.x
1416:), making patients susceptible to
1332:G-CSF is also a potent inducer of
1324:(Akt) signal transduction pathway.
1074:
1041:
1015:
982:
958:
939:
913:
894:
868:
849:
703:multicellular organism development
583:
501:
439:
418:
25:
1699:A combination of human G-CSF and
1624:Filgrastim was first marketed by
1428:, a type of white blood cell. In
1369:The gene for G-CSF is located on
27:Mammalian protein found in humans
5421:
3717:
3702:
3687:
3672:
3657:
2316:10.1046/j.1365-2141.2003.04043.x
1907:10.1097/00062752-200205000-00002
1400:Chemotherapy-induced neutropenia
1314:mitogen-activated protein kinase
587:
349:
342:
336:
313:
248:
241:
235:
210:
47:
4893:Interferon omega (IFN-ω, IFNW1)
4279:Polyinosinic:polycytidylic acid
2996:European Journal of Haematology
1676:G-CSF has been shown to reduce
1647:Another form of rhG-CSF called
1570:Walter and Eliza Hall Institute
1480:medication in the treatment of
1472:can be a severe side effect of
1465:Use in drug-induced neutropenia
1408:and unacceptably low levels of
2477:British Journal of Haematology
2304:British Journal of Haematology
2165:Journal of Theoretical Biology
598:More reference expression data
567:More reference expression data
459:olfactory zone of nasal mucosa
1:
2815:Amyotrophic Lateral Sclerosis
2220:10.1016/S0140-6736(88)91475-4
1895:Current Opinion in Hematology
1697:amyotrophic lateral sclerosis
1488:with the added use of G-CSF.
1318:phosphatidylinositol 3-kinase
1308:. G-CSF regulates them using
334:
233:
5444:Genes on human chromosome 17
3551:The Journal of Endocrinology
3259:Journal of Leukocyte Biology
3058:10.1016/0014-5793(92)81521-M
2883:10.1371/journal.pone.0090953
2690:10.1182/blood-2008-01-134817
2400:10.1097/JCP.0000000000000767
2267:10.1182/blood-2006-09-048686
1617:expression system is called
4737:Thrombopoietin (THPO, MGDF)
4503:Pegol sihematide (EPO-018B)
4423:Carbamylated erythropoietin
3403:10.4049/jimmunol.153.7.2868
1811:Bone Marrow Transplantation
1653:Chinese hamster ovary cells
1591:The FDA approved the first
1518:second and third trimesters
1173:colony-stimulating factor 3
708:granulocyte differentiation
5485:
3922:Colony-stimulating factors
3769:Colony-stimulating factors
2650:10.1016/j.bbmt.2006.02.006
2185:10.1016/j.jtbi.2015.08.015
1532:than people who have not.
1195:and release them into the
773:macrophage differentiation
768:neutrophil differentiation
31:
5286:Tofacitinib (tasocitinib)
5243:Tofacitinib (tasocitinib)
5150:Tofacitinib (tasocitinib)
4176:Histamine dihydrochloride
3652:
2933:10.1080/10428190290026231
2827:10.3109/17482960802588059
2725:. Crows Nest: ABC Books.
2440:Human Reproduction Update
1871:10.1007/s12185-016-2162-4
1792:"Mouse PubMed Reference:"
1774:"Human PubMed Reference:"
1640:) form has a much longer
1377:, and that two different
1212:colony-stimulating factor
1147:
1142:
1138:
1131:
1115:
1096:
1081:
1048:
1037:
1022:
989:
978:
965:
961:
946:
942:
933:
920:
916:
901:
897:
888:
875:
871:
856:
852:
843:
828:
821:
817:
801:
616:
612:
595:
586:
577:
564:
513:
504:
487:mucosa of paranasal sinus
451:
442:
412:
404:
400:
383:
370:
333:
312:
303:
299:
282:
269:
232:
209:
200:
196:
151:
148:
138:
131:
126:
91:
86:
69:
64:
59:
55:
46:
41:
4964:Interferon gamma (IFN-γ)
4308:Bacillus Calmette–Guérin
3590:Medical Subject Headings
2364:10.1177/0004867417720516
1498:hematopoietic stem cells
1257:, and a number of other
1109:Chr 11: 98.59 – 98.59 Mb
1102:Chr 17: 40.02 – 40.02 Mb
778:myeloid cell development
32:Not to be confused with
4864:Interferon beta (IFN-β)
4128:Other protein / peptide
4041:Ropeginterferon alfa-2b
3492:10.1073/pnas.90.11.5167
3442:10.1002/stem.5530120409
3084:Journal of Biochemistry
2921:Leukemia & Lymphoma
2591:10.1126/science.2420009
2540:10.1126/science.2990035
1603:Pharmaceutical variants
1404:Chemotherapy can cause
1334:hematopoietic stem cell
483:upper lobe of left lung
5342:Cardiotrophin 1 (CT-1)
3935:Efbemalenograstim alfa
3533:10.1006/abbi.1995.0047
1599:and sold as Fulphila.
1516:as well as during the
1202:Functionally, it is a
641:growth factor activity
5339:Additional cytokines:
5266:Decernotinib (VX-509)
4903:Peginterferon alfa-2b
4898:Peginterferon alfa-2a
4418:Asialo erythropoietin
4218:heterocyclic compound
4037:Peginterferon alfa-2b
4028:Peginterferon alfa-2a
3563:10.1677/joe.0.1490249
3390:Journal of Immunology
2970:10.1515/CCLM.2004.253
2453:10.1093/humupd/dms053
2106:10.1093/annonc/mdt226
1546:conditioning regimens
1536:Stem cell transplants
1492:Before blood donation
1302:neutrophil precursors
1249:G-CSF is produced by
1235:neutrophil precursors
367:11 D|11 62.45 cM
328:Chromosome 11 (mouse)
226:Chromosome 17 (human)
4854:Interferon alfacon-1
4483:Erythropoietin (EPO)
4051:Interferon alfacon-1
3271:10.1002/jlb.41.4.302
2003:10.1093/brain/awn243
1997:(Pt 12): 3335–3347.
1628:with the brand name
1544:, to compensate for
1452:bone mineral density
1329:Hematopoietic System
1183:that stimulates the
662:extracellular region
545:primary motor cortex
471:gastrocnemius muscle
87:List of PDB id codes
60:Available structures
5001:See IL-28R (IFNLR)
4969:Interferon gamma 1b
4859:Interferon alpha-n3
4171:Female sex steroids
4056:Interferon alpha-n3
3483:1993PNAS...90.5167H
3369:10.1021/bi00194a009
3049:1992FEBSL.314..435Z
2874:2014PLoSO...990953A
2583:1986Sci...232...61S
2532:1985Sci...229...16M
2177:2015JThBi.385...77C
2051:1986Natur.319..415N
1823:10.1038/bmt.2015.80
1686:Alzheimer's disease
1638:polyethylene glycol
1277:(rDNA) technology.
1245:Biological function
758:response to ethanol
667:extracellular space
5357:Oncostatin M (OSM)
4883:Interferon beta 1b
4878:Interferon beta 1a
4849:Interferon alfa n1
4844:Interferon alfa 2b
4839:Interferon alfa 2a
4673:Kinase inhibitors:
4274:polyribonucleotide
4252:Glatiramer acetate
4085:Interferon beta 1b
4080:Interferon beta 1a
4046:Interferon alfa n1
4033:Interferon alfa 2b
4024:Interferon alfa 2a
3309:10.1007/BF01534488
3169:10.1007/BF00278182
2800:clinicaltrials.gov
2142:Cancer Research UK
2094:Annals of Oncology
1651:is synthesised in
1352:and to counteract
1348:, to increase the
923:ENSMUSG00000038067
676:Biological process
655:Cellular component
624:Molecular function
5409:
5408:
5405:
5404:
5327:
5326:
5094:
5012:
5011:
4745:
4744:
4488:Erythropoietin-Fc
4362:Cytokine receptor
4328:
4327:
4194:
4193:
4123:
4122:
3859:
3858:
3735:
3734:
3477:(11): 5167–5171.
3363:(28): 8453–8463.
3195:Oncogene Research
2964:(12): 1347–1354.
2732:978-0-7333-1248-9
2721:Finkel E (2005).
2684:(12): 5440–5445.
2214:(8587): 667–672.
2100:(10): 2475–2484.
2045:(6052): 415–418.
1693:cerebral ischemia
1556:The skin disease
1410:white blood cells
1358:cerebral ischemia
1281:White blood cells
1171:), also known as
1158:
1157:
1154:
1153:
1127:
1126:
1092:
1091:
1071:
1070:
1033:
1032:
1012:
1011:
974:
973:
955:
954:
929:
928:
910:
909:
884:
883:
865:
864:
813:
812:
631:cytokine activity
608:
607:
604:
603:
573:
572:
560:
559:
541:medulla oblongata
529:lactiferous gland
517:entorhinal cortex
498:
497:
475:left uterine tube
396:
395:
295:
294:
122:
121:
118:
117:
70:Ortholog search:
16:(Redirected from
5476:
5454:Peptide hormones
5426:
5425:
5417:
5098:
5088:
5081:
4940:Decoy receptors:
4756:
4433:Darbepoetin alfa
4398:
4355:
4348:
4341:
4332:
4313:Melanoma vaccine
4298:Inosine pranobex
4230:hydroxyquinoline
4092:Interferon gamma
3918:
3909:
3893:Immunostimulants
3886:
3879:
3872:
3863:
3806:
3762:
3755:
3748:
3739:
3721:
3706:
3691:
3676:
3661:
3641:
3634:
3627:
3618:
3574:
3544:
3514:
3504:
3494:
3461:
3423:
3405:
3396:(7): 2868–2877.
3380:
3350:
3328:
3290:
3253:
3243:
3220:The EMBO Journal
3210:
3188:
3150:
3140:
3117:The EMBO Journal
3107:
3078:
3060:
3027:
2989:
2952:
2927:(6): 1179–1187.
2906:
2905:
2895:
2885:
2853:
2847:
2846:
2821:(5–6): 430–431.
2810:
2804:
2803:
2792:
2786:
2785:
2775:
2743:
2737:
2736:
2718:
2712:
2711:
2701:
2669:
2663:
2662:
2652:
2628:
2622:
2621:
2609:
2603:
2602:
2566:
2560:
2559:
2515:
2509:
2508:
2472:
2466:
2465:
2455:
2431:
2420:
2419:
2383:
2377:
2376:
2366:
2342:
2336:
2335:
2298:
2289:
2288:
2278:
2261:(8): 3424–3431.
2246:
2240:
2239:
2203:
2197:
2196:
2159:
2153:
2152:
2150:
2148:
2134:
2128:
2127:
2117:
2085:
2079:
2078:
2059:10.1038/319415a0
2034:
2025:
2024:
2014:
1982:
1976:
1975:
1965:
1954:10.1172/JCI23559
1948:(8): 2083–2098.
1933:
1927:
1926:
1890:
1884:
1883:
1873:
1849:
1843:
1842:
1817:(9): 1150–1156.
1806:
1800:
1799:
1788:
1782:
1781:
1770:
1764:
1754:
1743:
1733:
1558:Sweet's syndrome
1406:myelosuppression
1322:protein kinase B
1140:
1139:
1111:
1104:
1087:
1075:
1066:
1042:
1038:RefSeq (protein)
1028:
1016:
1007:
983:
959:
940:
914:
895:
869:
850:
819:
614:
600:
591:
584:
569:
509:
507:Top expressed in
502:
479:cartilage tissue
447:
445:Top expressed in
440:
419:
402:
392:
379:
368:
353:
346:
340:
329:
317:
301:
291:
278:
267:
252:
245:
239:
228:
214:
198:
192:
190:CSF3 - orthologs
143:
136:
113:
84:
78:
57:
56:
51:
39:
21:
5484:
5483:
5479:
5478:
5477:
5475:
5474:
5473:
5434:
5433:
5432:
5420:
5412:
5410:
5401:
5323:
5319:Deucravacitinib
5305:
5247:
5159:
5087:
5072:
5052:
5032:
5008:
4988:
4947:
4781:Interferon alfa
4741:
4700:
4680:
4629:
4563:
4559:Pegnartograstim
4544:Lipegfilgrastim
4507:
4453:Epoetin epsilon
4387:
4367:
4359:
4329:
4324:
4190:
4159:
4119:
4096:
4074:Interferon beta
4018:Interferon alfa
3993:
3949:Lipegfilgrastim
3900:
3890:
3860:
3855:
3837:
3819:
3802:
3789:
3771:
3766:
3736:
3731:
3728:
3722:
3713:
3707:
3698:
3692:
3683:
3677:
3668:
3662:
3648:
3645:
3582:
3577:
3547:
3517:
3464:
3426:
3383:
3353:
3341:(12): 795–799.
3331:
3293:
3256:
3213:
3191:
3153:
3110:
3081:
3030:
2992:
2955:
2918:
2914:
2912:Further reading
2909:
2855:
2854:
2850:
2812:
2811:
2807:
2794:
2793:
2789:
2745:
2744:
2740:
2733:
2720:
2719:
2715:
2671:
2670:
2666:
2630:
2629:
2625:
2611:
2610:
2606:
2577:(4746): 61–65.
2568:
2567:
2563:
2526:(4708): 16–22.
2517:
2516:
2512:
2474:
2473:
2469:
2433:
2432:
2423:
2385:
2384:
2380:
2357:(10): 980–989.
2344:
2343:
2339:
2300:
2299:
2292:
2248:
2247:
2243:
2205:
2204:
2200:
2161:
2160:
2156:
2146:
2144:
2136:
2135:
2131:
2087:
2086:
2082:
2036:
2035:
2028:
1984:
1983:
1979:
1935:
1934:
1930:
1892:
1891:
1887:
1851:
1850:
1846:
1808:
1807:
1803:
1790:
1789:
1785:
1772:
1771:
1767:
1755:
1746:
1734:
1725:
1721:
1709:
1661:
1605:
1566:
1554:
1538:
1494:
1467:
1402:
1397:
1367:
1350:neuroplasticity
1294:differentiation
1275:recombinant DNA
1247:
1149:View/Edit Mouse
1144:View/Edit Human
1107:
1100:
1097:Location (UCSC)
1083:
1062:
1058:
1054:
1050:
1024:
1003:
999:
995:
991:
904:ENSG00000108342
797:
713:immune response
671:
650:
596:
565:
556:
551:
547:
543:
539:
535:
531:
527:
523:
519:
505:
494:
489:
485:
481:
477:
473:
469:
467:muscle of thigh
465:
461:
457:
443:
387:
374:
366:
356:
355:
354:
347:
327:
304:Gene location (
286:
273:
265:
255:
254:
253:
246:
224:
201:Gene location (
152:
139:
132:
93:
71:
37:
28:
23:
22:
15:
12:
11:
5:
5482:
5480:
5472:
5471:
5466:
5461:
5456:
5451:
5449:Growth factors
5446:
5436:
5435:
5431:
5430:
5407:
5406:
5403:
5402:
5400:
5399:
5394:
5389:
5384:
5379:
5374:
5365:
5364:
5359:
5354:
5349:
5344:
5335:
5333:
5329:
5328:
5325:
5324:
5322:
5321:
5315:
5313:
5307:
5306:
5304:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5263:
5261:Cercosporamide
5257:
5255:
5249:
5248:
5246:
5245:
5240:
5235:
5230:
5225:
5220:
5215:
5210:
5205:
5203:Deuruxolitinib
5200:
5195:
5190:
5185:
5180:
5175:
5169:
5167:
5161:
5160:
5158:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5120:Deuruxolitinib
5117:
5112:
5106:
5104:
5095:
5078:
5074:
5073:
5071:
5070:
5062:
5060:
5054:
5053:
5051:
5050:
5042:
5040:
5034:
5033:
5031:
5030:
5022:
5020:
5014:
5013:
5010:
5009:
5007:
5006:
4998:
4996:
4994:IFNLR (λ, III)
4990:
4989:
4987:
4986:
4981:
4972:
4971:
4966:
4957:
4955:
4949:
4948:
4946:
4945:
4936:
4935:
4930:
4925:
4920:
4915:
4906:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4861:
4856:
4851:
4846:
4841:
4836:
4778:
4773:
4764:
4762:
4760:IFNAR (α/β, I)
4753:
4747:
4746:
4743:
4742:
4740:
4739:
4734:
4729:
4727:Promegapoietin
4724:
4719:
4710:
4708:
4706:Thrombopoietin
4702:
4701:
4699:
4698:
4690:
4688:
4682:
4681:
4679:
4678:
4669:
4668:
4663:
4658:
4653:
4651:Interleukin-34
4648:
4639:
4637:
4631:
4630:
4628:
4627:
4622:
4617:
4608:
4607:
4602:
4597:
4592:
4587:
4582:
4573:
4571:
4565:
4564:
4562:
4561:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4517:
4515:
4509:
4508:
4506:
4505:
4500:
4495:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4425:
4420:
4415:
4406:
4404:
4402:Erythropoietin
4395:
4389:
4388:
4386:
4385:
4377:
4375:
4369:
4368:
4360:
4358:
4357:
4350:
4343:
4335:
4326:
4325:
4323:
4322:
4321:
4320:
4315:
4310:
4300:
4295:
4294:
4293:
4283:
4282:
4281:
4271:
4270:
4269:
4264:
4259:
4254:
4244:
4239:
4238:
4237:
4227:
4226:
4225:
4215:
4214:
4213:
4202:
4200:
4196:
4195:
4192:
4191:
4189:
4188:
4183:
4178:
4173:
4167:
4165:
4161:
4160:
4158:
4157:
4152:
4147:
4142:
4137:
4135:Growth hormone
4131:
4129:
4125:
4124:
4121:
4120:
4118:
4117:
4112:
4106:
4104:
4098:
4097:
4095:
4094:
4089:
4088:
4087:
4082:
4077:
4065:
4064:
4063:
4061:feline "omega"
4058:
4053:
4048:
4043:
4030:
4021:
4015:
4003:
4001:
3995:
3994:
3992:
3991:
3990:
3989:
3979:
3978:
3977:
3972:
3962:
3961:
3960:
3955:
3942:
3937:
3926:
3924:
3915:
3906:
3902:
3901:
3891:
3889:
3888:
3881:
3874:
3866:
3857:
3856:
3854:
3853:
3851:Thrombopoietin
3847:
3845:
3839:
3838:
3836:
3835:
3833:Erythropoietin
3829:
3827:
3821:
3820:
3818:
3817:
3812:
3807:
3799:
3797:
3791:
3790:
3788:
3787:
3781:
3779:
3773:
3772:
3767:
3765:
3764:
3757:
3750:
3742:
3733:
3732:
3730:
3729:
3723:
3716:
3714:
3708:
3701:
3699:
3693:
3686:
3684:
3678:
3671:
3669:
3663:
3656:
3653:
3650:
3649:
3646:
3644:
3643:
3636:
3629:
3621:
3615:
3614:
3593:
3581:
3580:External links
3578:
3576:
3575:
3557:(2): 249–258.
3545:
3527:(2): 344–356.
3515:
3462:
3436:(4): 416–423.
3424:
3381:
3351:
3329:
3303:(6): 679–684.
3291:
3265:(4): 302–306.
3254:
3226:(3): 611–616.
3211:
3201:(3): 209–220.
3189:
3163:(2): 134–136.
3157:Human Genetics
3151:
3123:(3): 575–581.
3108:
3090:(3): 486–492.
3079:
3043:(3): 435–439.
3028:
3002:(4): 199–207.
2990:
2953:
2915:
2913:
2910:
2908:
2907:
2848:
2805:
2787:
2738:
2731:
2713:
2664:
2643:(6): 672–682.
2623:
2604:
2561:
2510:
2483:(1): 191–192.
2467:
2446:(3): 259–267.
2421:
2394:(5): 600–604.
2378:
2337:
2310:(2): 329–336.
2290:
2241:
2198:
2154:
2129:
2080:
2026:
1977:
1928:
1901:(3): 183–189.
1885:
1864:(2): 129–140.
1844:
1801:
1783:
1765:
1744:
1722:
1720:
1717:
1716:
1715:
1708:
1705:
1660:
1657:
1634:PEG-filgrastim
1604:
1601:
1565:
1562:
1553:
1550:
1537:
1534:
1493:
1490:
1466:
1463:
1401:
1398:
1396:
1393:
1366:
1363:
1362:
1361:
1342:
1338:
1337:
1330:
1326:
1325:
1286:G-CSF-receptor
1282:
1246:
1243:
1220:pharmaceutical
1156:
1155:
1152:
1151:
1146:
1136:
1135:
1129:
1128:
1125:
1124:
1122:
1120:
1113:
1112:
1105:
1098:
1094:
1093:
1090:
1089:
1079:
1078:
1072:
1069:
1068:
1046:
1045:
1039:
1035:
1034:
1031:
1030:
1020:
1019:
1013:
1010:
1009:
987:
986:
980:
976:
975:
972:
971:
963:
962:
956:
953:
952:
944:
943:
937:
931:
930:
927:
926:
918:
917:
911:
908:
907:
899:
898:
892:
886:
885:
882:
881:
873:
872:
866:
863:
862:
854:
853:
847:
841:
840:
835:
830:
826:
825:
815:
814:
811:
810:
799:
798:
796:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
658:
656:
652:
651:
649:
648:
643:
638:
636:enzyme binding
633:
627:
625:
621:
620:
610:
609:
606:
605:
602:
601:
593:
592:
581:
575:
574:
571:
570:
562:
561:
558:
557:
555:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
511:
510:
499:
496:
495:
493:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
449:
448:
436:
435:
427:
416:
410:
409:
406:RNA expression
398:
397:
394:
393:
385:
381:
380:
372:
369:
364:
358:
357:
348:
341:
335:
331:
330:
325:
319:
318:
310:
309:
297:
296:
293:
292:
284:
280:
279:
271:
268:
263:
257:
256:
247:
240:
234:
230:
229:
222:
216:
215:
207:
206:
194:
193:
150:
146:
145:
137:
129:
128:
124:
123:
120:
119:
116:
115:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5481:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5441:
5439:
5429:
5424:
5419:
5415:
5398:
5395:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5370:
5367:
5366:
5363:
5360:
5358:
5355:
5353:
5350:
5348:
5345:
5343:
5340:
5337:
5336:
5334:
5330:
5320:
5317:
5316:
5314:
5312:
5308:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5258:
5256:
5254:
5250:
5244:
5241:
5239:
5236:
5234:
5231:
5229:
5226:
5224:
5221:
5219:
5216:
5214:
5211:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5170:
5168:
5166:
5162:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5107:
5105:
5103:
5099:
5096:
5092:
5086:
5082:
5079:
5075:
5068:
5064:
5063:
5061:
5059:
5055:
5048:
5044:
5043:
5041:
5039:
5035:
5028:
5024:
5023:
5021:
5019:
5015:
5004:
5000:
4999:
4997:
4995:
4991:
4985:
4982:
4980:
4977:
4974:
4973:
4970:
4967:
4965:
4962:
4959:
4958:
4956:
4954:
4953:IFNGR (γ, II)
4950:
4944:
4941:
4938:
4937:
4934:
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4908:
4907:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4873:
4869:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4834:
4830:
4826:
4822:
4818:
4814:
4810:
4806:
4802:
4798:
4794:
4790:
4786:
4782:
4779:
4777:
4774:
4772:
4771:Albinterferon
4769:
4766:
4765:
4763:
4761:
4757:
4754:
4752:
4748:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4712:
4711:
4709:
4707:
4703:
4696:
4692:
4691:
4689:
4687:
4683:
4677:
4674:
4671:
4670:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4641:
4640:
4638:
4636:
4632:
4626:
4623:
4621:
4618:
4616:
4613:
4610:
4609:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4575:
4574:
4572:
4570:
4569:GM-CSF (CSF2)
4566:
4560:
4557:
4555:
4554:Pegfilgrastim
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4519:
4518:
4516:
4514:
4510:
4504:
4501:
4499:
4496:
4494:
4491:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4473:Epoetin theta
4471:
4469:
4468:Epoetin omega
4466:
4464:
4463:Epoetin kappa
4461:
4459:
4458:Epoetin gamma
4456:
4454:
4451:
4449:
4448:Epoetin delta
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4408:
4407:
4405:
4403:
4399:
4396:
4394:
4390:
4383:
4379:
4378:
4376:
4374:
4370:
4366:
4363:
4356:
4351:
4349:
4344:
4342:
4337:
4336:
4333:
4319:
4316:
4314:
4311:
4309:
4306:
4305:
4304:
4301:
4299:
4296:
4292:
4289:
4288:
4287:
4284:
4280:
4277:
4276:
4275:
4272:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4249:
4248:
4247:oligopeptides
4245:
4243:
4240:
4236:
4233:
4232:
4231:
4228:
4224:
4221:
4220:
4219:
4216:
4212:
4209:
4208:
4207:
4204:
4203:
4201:
4197:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4168:
4166:
4162:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4132:
4130:
4126:
4116:
4113:
4111:
4108:
4107:
4105:
4103:
4099:
4093:
4090:
4086:
4083:
4081:
4078:
4075:
4072:
4071:
4069:
4066:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4038:
4034:
4031:
4029:
4025:
4022:
4019:
4016:
4014:
4013:Albinterferon
4011:
4010:
4008:
4005:
4004:
4002:
4000:
3996:
3988:
3985:
3984:
3983:
3980:
3976:
3973:
3971:
3968:
3967:
3966:
3963:
3959:
3956:
3954:
3953:Pegfilgrastim
3950:
3946:
3943:
3941:
3940:Eflapegrastim
3938:
3936:
3933:
3932:
3931:
3928:
3927:
3925:
3923:
3919:
3916:
3914:
3910:
3907:
3903:
3898:
3894:
3887:
3882:
3880:
3875:
3873:
3868:
3867:
3864:
3852:
3849:
3848:
3846:
3844:
3840:
3834:
3831:
3830:
3828:
3826:
3822:
3816:
3813:
3811:
3808:
3805:
3801:
3800:
3798:
3796:
3792:
3786:
3785:Interleukin 3
3783:
3782:
3780:
3778:
3774:
3770:
3763:
3758:
3756:
3751:
3749:
3744:
3743:
3740:
3726:
3720:
3715:
3711:
3705:
3700:
3696:
3690:
3685:
3681:
3675:
3670:
3666:
3660:
3655:
3651:
3642:
3637:
3635:
3630:
3628:
3623:
3622:
3619:
3612:
3608:
3607:
3602:
3598:
3594:
3591:
3587:
3584:
3583:
3579:
3572:
3568:
3564:
3560:
3556:
3552:
3546:
3542:
3538:
3534:
3530:
3526:
3522:
3516:
3512:
3508:
3503:
3498:
3493:
3488:
3484:
3480:
3476:
3472:
3468:
3463:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3431:
3425:
3421:
3417:
3413:
3409:
3404:
3399:
3395:
3391:
3387:
3382:
3378:
3374:
3370:
3366:
3362:
3358:
3352:
3348:
3344:
3340:
3336:
3330:
3326:
3322:
3318:
3314:
3310:
3306:
3302:
3298:
3292:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3260:
3255:
3251:
3247:
3242:
3237:
3233:
3229:
3225:
3221:
3217:
3212:
3208:
3204:
3200:
3196:
3190:
3186:
3182:
3178:
3174:
3170:
3166:
3162:
3158:
3152:
3148:
3144:
3139:
3134:
3130:
3126:
3122:
3118:
3114:
3109:
3105:
3101:
3097:
3093:
3089:
3085:
3080:
3076:
3072:
3068:
3064:
3059:
3054:
3050:
3046:
3042:
3038:
3034:
3029:
3025:
3021:
3017:
3013:
3009:
3005:
3001:
2997:
2991:
2987:
2983:
2979:
2975:
2971:
2967:
2963:
2959:
2954:
2950:
2946:
2942:
2938:
2934:
2930:
2926:
2922:
2917:
2916:
2911:
2903:
2899:
2894:
2889:
2884:
2879:
2875:
2871:
2868:(3): e90953.
2867:
2863:
2859:
2852:
2849:
2844:
2840:
2836:
2832:
2828:
2824:
2820:
2816:
2809:
2806:
2801:
2797:
2791:
2788:
2783:
2779:
2774:
2769:
2765:
2761:
2757:
2753:
2749:
2742:
2739:
2734:
2728:
2724:
2717:
2714:
2709:
2705:
2700:
2695:
2691:
2687:
2683:
2679:
2675:
2668:
2665:
2660:
2656:
2651:
2646:
2642:
2638:
2634:
2627:
2624:
2619:
2615:
2608:
2605:
2600:
2596:
2592:
2588:
2584:
2580:
2576:
2572:
2565:
2562:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2525:
2521:
2514:
2511:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2478:
2471:
2468:
2463:
2459:
2454:
2449:
2445:
2441:
2437:
2430:
2428:
2426:
2422:
2417:
2413:
2409:
2405:
2401:
2397:
2393:
2389:
2382:
2379:
2374:
2370:
2365:
2360:
2356:
2352:
2348:
2341:
2338:
2333:
2329:
2325:
2321:
2317:
2313:
2309:
2305:
2297:
2295:
2291:
2286:
2282:
2277:
2272:
2268:
2264:
2260:
2256:
2252:
2245:
2242:
2237:
2233:
2229:
2225:
2221:
2217:
2213:
2209:
2202:
2199:
2194:
2190:
2186:
2182:
2178:
2174:
2170:
2166:
2158:
2155:
2143:
2139:
2133:
2130:
2125:
2121:
2116:
2111:
2107:
2103:
2099:
2095:
2091:
2084:
2081:
2076:
2072:
2068:
2064:
2060:
2056:
2052:
2048:
2044:
2040:
2033:
2031:
2027:
2022:
2018:
2013:
2008:
2004:
2000:
1996:
1992:
1988:
1981:
1978:
1973:
1969:
1964:
1959:
1955:
1951:
1947:
1943:
1939:
1932:
1929:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1896:
1889:
1886:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1848:
1845:
1840:
1836:
1832:
1828:
1824:
1820:
1816:
1812:
1805:
1802:
1797:
1793:
1787:
1784:
1779:
1775:
1769:
1766:
1762:
1758:
1753:
1751:
1749:
1745:
1741:
1737:
1732:
1730:
1728:
1724:
1718:
1714:
1711:
1710:
1706:
1704:
1702:
1698:
1694:
1689:
1687:
1683:
1679:
1674:
1672:
1668:
1664:
1658:
1656:
1654:
1650:
1645:
1643:
1639:
1635:
1631:
1627:
1622:
1620:
1616:
1615:
1610:
1602:
1600:
1598:
1594:
1589:
1587:
1586:United States
1583:
1579:
1575:
1571:
1563:
1561:
1559:
1551:
1549:
1547:
1543:
1535:
1533:
1531:
1527:
1523:
1522:Breastfeeding
1519:
1515:
1511:
1507:
1503:
1502:leukapheresis
1499:
1491:
1489:
1487:
1483:
1482:schizophrenia
1479:
1478:antipsychotic
1475:
1471:
1464:
1462:
1460:
1455:
1453:
1448:
1445:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1399:
1394:
1392:
1390:
1385:
1382:
1380:
1376:
1372:
1371:chromosome 17
1364:
1359:
1355:
1351:
1347:
1343:
1340:
1339:
1335:
1331:
1328:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1280:
1279:
1278:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1244:
1242:
1240:
1236:
1231:
1229:
1225:
1221:
1217:
1213:
1209:
1205:
1200:
1198:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1166:
1162:
1150:
1145:
1141:
1137:
1134:
1130:
1123:
1121:
1118:
1114:
1110:
1106:
1103:
1099:
1095:
1088:
1086:
1080:
1076:
1073:
1067:
1065:
1061:
1057:
1053:
1047:
1043:
1040:
1036:
1029:
1027:
1021:
1017:
1014:
1008:
1006:
1002:
998:
994:
988:
984:
981:
979:RefSeq (mRNA)
977:
970:
969:
964:
960:
957:
951:
950:
945:
941:
938:
936:
932:
925:
924:
919:
915:
912:
906:
905:
900:
896:
893:
891:
887:
880:
879:
874:
870:
867:
861:
860:
855:
851:
848:
846:
842:
839:
836:
834:
831:
827:
824:
820:
816:
809:
805:
800:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
659:
657:
654:
653:
647:
644:
642:
639:
637:
634:
632:
629:
628:
626:
623:
622:
619:
618:Gene ontology
615:
611:
599:
594:
590:
585:
582:
580:
576:
568:
563:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
515:
512:
508:
503:
500:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
453:
450:
446:
441:
438:
437:
434:
432:
428:
426:
425:
421:
420:
417:
415:
411:
407:
403:
399:
391:
386:
382:
378:
373:
363:
359:
352:
345:
339:
332:
324:
320:
316:
311:
307:
302:
298:
290:
285:
281:
277:
272:
262:
258:
251:
244:
238:
231:
227:
221:
217:
213:
208:
204:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
147:
142:
135:
130:
125:
114:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
35:
30:
19:
5377:Lestaurtinib
5368:
5338:
5276:Ritlecitinib
5208:Lestaurtinib
5155:Upadacitinib
4984:Fontolizumab
4975:
4960:
4939:
4928:Rontalizumab
4909:
4767:
4722:Pegacaristim
4713:
4672:
4642:
4635:M-CSF (CSF1)
4615:Mavrilimumab
4611:
4605:Sargramostim
4595:Molgramostim
4580:Ecogramostim
4576:
4549:Nartograstim
4528:
4520:
4513:G-CSF (CSF3)
4498:Peginesatide
4478:Epoetin zeta
4443:Epoetin beta
4438:Epoetin alfa
4409:
4318:Sipuleucel-T
4286:thiazolidine
4140:Immunocyanin
4102:Interleukins
4067:
4006:
3975:Sargramostim
3970:Molgramostim
3929:
3809:
3724:
3709:
3694:
3679:
3664:
3604:
3554:
3550:
3524:
3520:
3474:
3470:
3433:
3429:
3393:
3389:
3360:
3357:Biochemistry
3356:
3338:
3334:
3300:
3296:
3262:
3258:
3223:
3219:
3198:
3194:
3160:
3156:
3120:
3116:
3087:
3083:
3040:
3037:FEBS Letters
3036:
2999:
2995:
2961:
2957:
2924:
2920:
2865:
2861:
2851:
2818:
2814:
2808:
2799:
2790:
2758:(1): 55–72.
2755:
2752:Neuroscience
2751:
2741:
2722:
2716:
2681:
2677:
2667:
2640:
2636:
2626:
2617:
2607:
2574:
2570:
2564:
2523:
2519:
2513:
2480:
2476:
2470:
2443:
2439:
2391:
2387:
2381:
2354:
2350:
2340:
2307:
2303:
2258:
2254:
2244:
2211:
2207:
2201:
2168:
2164:
2157:
2145:. Retrieved
2141:
2132:
2097:
2093:
2083:
2042:
2038:
1994:
1990:
1980:
1945:
1941:
1931:
1898:
1894:
1888:
1861:
1857:
1847:
1814:
1810:
1804:
1795:
1786:
1777:
1768:
1690:
1682:amyloid beta
1678:inflammation
1675:
1665:
1662:
1646:
1623:
1612:
1606:
1590:
1567:
1555:
1539:
1514:implantation
1495:
1486:rechallenged
1468:
1456:
1449:
1446:
1442:chemotherapy
1426:granulocytes
1403:
1386:
1383:
1379:polypeptides
1368:
1346:neurogenesis
1298:granulocytes
1296:into mature
1248:
1232:
1210:, a type of
1201:
1189:granulocytes
1181:glycoprotein
1176:
1172:
1168:
1164:
1160:
1159:
1082:
1056:NP_001171618
1049:
1023:
997:NM_001178147
990:
966:
947:
921:
902:
876:
857:
837:
832:
429:
422:
149:External IDs
92:
29:
5387:Quizartinib
5382:Midostaurin
5271:Peficitinib
5233:Ruxolitinib
5228:Peficitinib
5183:Baricitinib
5145:Ruxolitinib
5140:Peficitinib
5135:Oclacitinib
5130:Momelotinib
5115:Baricitinib
5110:Abrocitinib
5018:Interleukin
4976:Antibodies:
4933:Sifalimumab
4918:Faralimomab
4913:Anifrolumab
4910:Antibodies:
4732:Romiplostim
4717:Eltrombopag
4686:SCF (c-Kit)
4612:Antibodies:
4600:Regramostim
4534:Lenograstim
4262:Thymosin α1
4257:Thymopentin
4242:Mifamurtide
4206:beta-glucan
4110:Aldesleukin
3999:Interferons
3958:Lenograstim
3647:PDB gallery
2618:www.fda.gov
2147:12 November
1649:lenograstim
1609:recombinant
1552:Side effect
1504:for use in
1470:Neutropenia
1438:neutropenia
1395:Medical use
1316:(MAPK) and
1306:neutrophils
1304:and mature
1290:bone marrow
1255:macrophages
1251:endothelium
1239:neutrophils
1237:and mature
1228:lenograstim
1197:bloodstream
1187:to produce
1185:bone marrow
388:98,594,455
375:98,592,089
287:40,017,813
274:40,015,361
127:Identifiers
5438:Categories
5372:Emfilermin
5223:Pacritinib
5125:Filgotinib
5091:inhibitors
4979:Emapalumab
4751:Interferon
4676:Agerafenib
4666:Mirimostim
4656:Lanimostim
4590:Milodistim
4539:Leridistim
4524:Filgrastim
4365:modulators
4235:Roquinimex
4223:Plerixafor
4155:Tasonermin
4145:Pegademase
4115:Oprelvekin
3945:Filgrastim
3905:Endogenous
3430:Stem Cells
1763:, May 2017
1742:, May 2017
1719:References
1713:PEGylation
1701:cord blood
1619:filgrastim
1593:biosimilar
1434:hematology
1418:infections
1414:leukopenia
1263:amino-acid
1224:filgrastim
1193:stem cells
553:integument
549:blastocyst
433:(ortholog)
170:HomoloGene
5464:Cytokines
5397:Sunitinib
5392:Sorafenib
5301:ZM-449829
5291:WHI-P 154
5281:TCS-21311
5218:NSC-33994
5173:Atiprimod
4961:Agonists:
4943:Bifarcept
4768:Agonists:
4714:Agonists:
4646:Cilmostim
4643:Agonists:
4620:Namilumab
4577:Agonists:
4521:Agonists:
4410:Agonists:
4373:Chemokine
4291:Pidotimod
4199:Exogenous
4186:Vitamin D
4181:Poly ICLC
4150:Prolactin
3913:Cytokines
2171:: 77–89.
1680:, reduce
1667:Mesoblast
1642:half-life
1588:in 1986.
1574:Australia
1526:clearance
1510:pregnancy
1474:clozapine
1354:apoptosis
1085:NP_034101
1064:NP_757374
1060:NP_757373
1052:NP_000750
1026:NM_009971
1005:NM_172220
1001:NM_172219
993:NM_000759
823:Orthologs
525:CA3 field
463:vena cava
178:GeneCards
5296:ZM-39923
5213:NSC-7908
5178:AZD-1480
5069:instead.
5049:instead.
5029:instead.
5005:instead.
4923:MEDI-545
4697:instead.
4625:Otilimab
4428:CNTO-530
4384:instead.
4303:vaccines
4267:Thymulin
4211:Lentinan
3987:Ancestim
3777:CFU-GEMM
3458:22671177
3420:25302361
3335:Leukemia
3325:10909775
3287:26877622
3193:17q21".
3075:28422738
3024:35573524
2986:11414705
2978:15576295
2949:45748453
2941:12152985
2902:24621603
2862:PloS One
2843:43087598
2835:19922135
2782:19500657
2708:18287516
2659:16737941
2556:45170361
2462:23287427
2416:41269943
2408:28817489
2373:28747065
2324:12542495
2285:17192391
2236:21255495
2193:26343861
2124:23788754
2021:18835867
1972:16007267
1915:11953662
1880:27943116
1839:20774089
1831:25915812
1759:–
1738:–
1707:See also
1659:Research
1630:Neupogen
1530:leukemia
1459:telomere
1430:oncology
1365:Genetics
1312:and Ras/
1204:cytokine
1179:), is a
1133:Wikidata
802:Sources:
455:testicle
5428:Biology
5238:SD-1008
4413:ARA-290
4076:natural
4020:natural
3843:CFU-Meg
3611:PDBe-KB
3601:UniProt
3571:8708536
3541:8554326
3511:7685117
3479:Bibcode
3450:7524894
3412:7522243
3377:7518249
3347:3501046
3317:3499671
3279:3494801
3250:3034599
3207:2453015
3177:2448221
3147:2423327
3138:1166801
3104:1692828
3067:1281794
3045:Bibcode
3016:1281454
2893:3951247
2870:Bibcode
2773:5966834
2699:2424146
2599:2420009
2579:Bibcode
2571:Science
2548:2990035
2528:Bibcode
2520:Science
2497:7504506
2332:5785335
2276:1852257
2228:2895212
2173:Bibcode
2115:3841419
2075:4325026
2067:3484805
2047:Bibcode
2012:2639207
1963:1172228
1923:5774130
1761:Ensembl
1740:Ensembl
1614:E. coli
1582:Germany
1564:History
1512:during
1375:introns
1341:Neurons
1320:(PI3K)/
1267:protein
1216:tissues
1208:hormone
935:UniProt
890:Ensembl
829:Species
808:QuickGO
408:pattern
266:17q21.1
166:1339751
134:Aliases
5414:Portal
5332:Others
5198:CYT387
5188:CHZ868
5077:Others
4833:IFNA21
4829:IFNA17
4825:IFNA16
4821:IFNA14
4817:IFNA13
4813:IFNA10
3965:GM-CSF
3795:CFU-GM
3606:P09919
3592:(MeSH)
3569:
3539:
3509:
3499:
3456:
3448:
3418:
3410:
3375:
3345:
3323:
3315:
3285:
3277:
3248:
3241:553441
3238:
3205:
3185:469736
3183:
3175:
3145:
3135:
3102:
3073:
3065:
3022:
3014:
2984:
2976:
2947:
2939:
2900:
2890:
2841:
2833:
2780:
2770:
2729:
2706:
2696:
2657:
2597:
2554:
2546:
2505:414133
2503:
2495:
2460:
2414:
2406:
2371:
2330:
2322:
2283:
2273:
2234:
2226:
2208:Lancet
2191:
2122:
2112:
2073:
2065:
2039:Nature
2019:
2009:
1970:
1960:
1921:
1913:
1878:
1837:
1829:
1440:after
1422:sepsis
1265:-long
1259:immune
1218:. The
1119:search
1117:PubMed
968:P09920
949:P09919
845:Entrez
579:BioGPS
533:cervix
521:embryo
158:138970
5459:Amgen
4872:IFNB3
4868:IFNB1
4809:IFNA8
4805:IFNA7
4801:IFNA6
4797:IFNA5
4793:IFNA4
4789:IFNA2
4785:IFNA1
4164:Other
4007:alpha
3930:G-CSF
3825:CFU-E
3502:46676
3454:S2CID
3416:S2CID
3321:S2CID
3283:S2CID
3181:S2CID
3071:S2CID
3020:S2CID
2982:S2CID
2945:S2CID
2839:S2CID
2678:Blood
2552:S2CID
2501:S2CID
2412:S2CID
2328:S2CID
2255:Blood
2232:S2CID
2071:S2CID
1991:Brain
1919:S2CID
1835:S2CID
1626:Amgen
1597:Mylan
1578:Japan
1476:, an
1177:CSF 3
1165:G-CSF
878:12985
838:Mouse
833:Human
804:Amigo
491:gonad
431:Mouse
424:Human
371:Start
306:Mouse
270:Start
203:Human
5311:TYK2
5253:JAK3
5165:JAK2
5102:JAK1
5067:here
5065:See
5047:here
5045:See
5038:TGFβ
5027:here
5025:See
5003:here
4695:here
4693:See
4382:here
4380:See
4068:beta
3725:2d9q
3710:1rhg
3695:1pgr
3680:1gnc
3665:1cd9
3599:for
3567:PMID
3537:PMID
3507:PMID
3446:PMID
3408:PMID
3373:PMID
3343:PMID
3313:PMID
3275:PMID
3246:PMID
3203:PMID
3173:PMID
3143:PMID
3100:PMID
3063:PMID
3012:PMID
2974:PMID
2937:PMID
2898:PMID
2831:PMID
2778:PMID
2727:ISBN
2704:PMID
2655:PMID
2595:PMID
2544:PMID
2493:PMID
2458:PMID
2404:PMID
2369:PMID
2320:PMID
2281:PMID
2224:PMID
2189:PMID
2149:2014
2120:PMID
2063:PMID
2017:PMID
1968:PMID
1911:PMID
1876:PMID
1827:PMID
1607:The
1580:and
1432:and
1420:and
1284:The
1271:mole
1226:and
1206:and
1191:and
1169:GCSF
859:1440
414:Bgee
362:Band
323:Chr.
261:Band
220:Chr.
182:CSF3
174:7677
154:OMIM
141:CSF3
111:1RHG
107:1PGR
103:1GNC
99:1CD9
95:2D9Q
76:RCSB
73:PDBe
42:CSF3
5085:JAK
5058:TNF
4393:CSF
3982:SCF
3897:L03
3597:PDB
3559:doi
3555:149
3529:doi
3525:324
3497:PMC
3487:doi
3438:doi
3398:doi
3394:153
3365:doi
3305:doi
3267:doi
3236:PMC
3228:doi
3165:doi
3133:PMC
3125:doi
3092:doi
3088:107
3053:doi
3041:314
3004:doi
2966:doi
2929:doi
2888:PMC
2878:doi
2823:doi
2768:PMC
2760:doi
2756:163
2694:PMC
2686:doi
2682:111
2645:doi
2587:doi
2575:232
2536:doi
2524:229
2485:doi
2448:doi
2396:doi
2359:doi
2312:doi
2308:120
2271:PMC
2263:doi
2259:109
2216:doi
2181:doi
2169:385
2110:PMC
2102:doi
2055:doi
2043:319
2007:PMC
1999:doi
1995:131
1958:PMC
1950:doi
1946:115
1903:doi
1866:doi
1862:105
1819:doi
1671:SDF
1167:or
384:End
283:End
186:OMA
162:MGI
66:PDB
5440::
4870:,
4831:,
4827:,
4823:,
4819:,
4815:,
4811:,
4807:,
4803:,
4799:,
4795:,
4791:,
4787:,
4070::
4039:/
4035:/
4026:/
4009::
3951:/
3947:/
3603::
3565:.
3553:.
3535:.
3523:.
3505:.
3495:.
3485:.
3475:90
3473:.
3469:.
3452:.
3444:.
3434:12
3432:.
3414:.
3406:.
3392:.
3388:.
3371:.
3361:33
3359:.
3337:.
3319:.
3311:.
3301:13
3299:.
3281:.
3273:.
3263:41
3261:.
3244:.
3234:.
3222:.
3218:.
3197:.
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