848:
3243:
3228:
3213:
825:
3588:
3528:
3258:
2943:
2928:
2913:
3618:
3558:
3633:
3603:
3573:
3543:
3393:
2883:
2868:
2853:
722:
747:
2778:
3648:
2808:
2973:
3138:
3123:
3108:
3093:
3078:
3018:
3003:
3513:
3453:
3498:
3483:
3438:
3468:
3423:
2988:
1106:
1099:
2793:
3348:
3288:
2838:
1113:
3408:
3363:
3318:
3333:
2898:
3378:
3063:
3048:
854:
753:
3273:
47:
3033:
3153:
2823:
3168:
2958:
3198:
3183:
3303:
2102:
at position 12 (written as Gly12Val, G12V, or H-RasV). The altered HRAS protein is permanently activated within the cell. This overactive protein directs the cell to grow and divide in the absence of outside signals, leading to uncontrolled cell division and the formation of a tumor. Mutations in the
2060:
at position 12 (written as Gly12Ser or G12S). The mutations responsible for
Costello syndrome lead to the production of an HRAS protein that is permanently active. Instead of triggering cell growth in response to particular signals from outside the cell, the overactive protein directs cells to grow
73:
2094:. One specific mutation has been identified in a significant percentage of bladder tumors; this mutation substitutes one protein building block (amino acid) for another amino acid in the HRAS protein. Specifically, the mutation replaces the amino acid
3242:
3227:
3212:
3587:
2119:
gene are probably involved in the development of several other types of cancer. These mutations lead to an HRAS protein that is always active and can direct cells to grow and divide without control. Recent studies suggest that
3527:
3257:
5423:
2942:
2927:
2912:
2065:
gene cause the other features of
Costello syndrome (such as mental retardation, distinctive facial features, and heart problems), but many of the signs and symptoms probably result from cell overgrowth and abnormal cell
6450:
3617:
3557:
3632:
3602:
3572:
3542:
3392:
2882:
2867:
2852:
1994:. Upon conversion of GTP to GDP, HRAS is turned off. The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein (GAP) class, for example
2777:
2417:"Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition"
3647:
3688:
2807:
2972:
2323:
Chiosea SI, Williams L, Griffith CC, Thompson LD, Weinreb I, Bauman JE, Luvison A, Roy S, Seethala RR, Nikiforova MN (Jun 2015). "Molecular characterization of apocrine salivary duct carcinoma".
3137:
3122:
3107:
3092:
5416:
3077:
5409:
2227:
Wong-Staal F, Dalla-Favera R, Franchini G, Gelmann EP, Gallo RC (Jul 1981). "Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses".
3017:
3002:
3512:
3452:
2027:
4531:
3497:
3482:
3437:
1962:, a process by which proteins and second messengers relay signals from outside the cell to the cell nucleus and instructs the cell to grow or divide. The HRAS protein is a
6324:
3681:
3467:
3422:
2061:
and divide constantly. This uncontrolled cell division can result in the formation of noncancerous and cancerous tumors. Researchers are uncertain how mutations in the
861:
760:
2987:
3251:: CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
3236:: CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
3221:: CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
1978:. HRAS acts as a molecular on/off switch, once it is turned on it recruits and activates proteins necessary for the propagation of the receptor's signal, such as
5432:
3945:
3674:
2124:
mutations are common in thyroid, salivary duct carcinoma, epithelial-myoepithelial carcinoma, and kidney cancers. DNA copy-number gain of a segment containing
654:, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK2
4175:
3596:: REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS
2792:
1571:
683:
5475:
1552:
5920:
4019:
4014:
3347:
3287:
2837:
6427:
6063:
5971:
5868:
5224:
2015:
5582:
5538:
6385:
4524:
3407:
3362:
4366:
4754:
3317:
5465:
3332:
2633:
Mascaux C, Iannino N, Martin B, Paesmans M, Berghmans T, Dusart M, Haller A, Lothaire P, Meert AP, Noel S, Lafitte JJ, Sculier JP (Jan 2005).
6470:
2757:
2209:
4723:
2897:
2191:
6364:
6287:
3377:
3062:
3047:
3536:: CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP
3266:: CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP
1990:
in the active state and possesses an intrinsic enzymatic activity that cleaves the terminal phosphate of this nucleotide converting it to
3272:
847:
6407:
4517:
1822:
2951:: X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
2936:: X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
2921:: X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
5816:
3626:: MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS
3566:: MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS
2600:
Tennant RW, Stasiewicz S, Eastin WC, Mennear JH, Spalding JW (2002). "The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model".
824:
1815:
5946:
3871:
3032:
2309:
2107:
gene also have been associated with the progression of bladder cancer and an increased risk of tumor recurrence after treatment.
6319:
3152:
2822:
2049:. Each of these mutations changes an amino acid in a critical region of the HRAS protein. The most common mutation replaces the
5314:
3641:: THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
3611:: THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
3581:: THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
3551:: THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
3401:: THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
3167:
2178:
2157:
2082:. Some gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes are called
2018:. These proteins all are regulated in the same manner and appear to differ largely in their sites of action within the cell.
6375:
5577:
5553:
5533:
5309:
3733:
2957:
2891:: THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY
2876:: THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY
2861:: THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY
2635:"The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis"
746:
721:
6182:
2174:
70:
6134:
5587:
5331:
2153:
2132:
patient's outcome. The HRAS protein also may be produced at higher levels (overexpressed) in other types of cancer cells.
3197:
6340:
6315:
6306:
6168:
5821:
5379:
4696:
663:
2786:: STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS
5448:
5301:
3985:
6199:
860:
759:
3999:
3907:
3823:
3794:
3656:: THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
5360:
4901:
4799:
4624:
4620:
4597:
4570:
4557:
4544:
4395:
4233:
4033:
3182:
2750:
853:
752:
2816:: THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS
6422:
6009:
5512:
5494:
4915:
4610:
4575:
4548:
3852:
3738:
2729:
1620:
671:
1958:
that span the cell's plasma membrane. Once activated, receptors stimulate signal transduction events in the
6215:
5925:
5895:
5880:
5843:
5285:
5248:
4587:
4078:
3756:
1955:
1601:
1597:
3302:
5503:
5015:
4655:
4455:
4264:
3146:: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
3131:: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
3116:: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
3101:: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
1987:
1923:
2981:: C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'- TRIPHOSPHATE
6296:
6107:
5875:
5145:
5053:
3954:
3765:
3709:
3697:
1998:. In turn HRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example
1991:
1899:
735:
2270:
Russell MW, Munroe DJ, Bric E, Housman DE, Dietz-Band J, Riethman HC, Collins FS, Brody LC (Jul 1996).
5699:
4380:
2743:
2428:
2236:
31:
650:
6278:
6151:
5350:
3838:
1794:
1790:
1761:
1757:
1727:
1723:
1702:
1690:
6475:
5684:
5649:
5365:
4931:
4509:
3893:
3086:: CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS
2725:
2701:
2621:
2588:
2551:
2503:
2348:
695:
5401:
1798:
1769:
1765:
1731:
1698:
1694:
5572:
5528:
4605:
2693:
2664:
2613:
2580:
2543:
2495:
2456:
2397:
2340:
2291:
2252:
2046:
643:
63:
1887:
5543:
5521:
5517:
4995:
4941:
4923:
4789:
4779:
4733:
4330:
4107:
4093:
2685:
2654:
2646:
2605:
2572:
2535:
2487:
2446:
2436:
2387:
2379:
2332:
2283:
2244:
2083:
1935:
1487:
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
1105:
1098:
940:
871:
815:
770:
6240:
5781:
4808:
3521:: Crystal structure analysis of a fluorescent form of H-Ras p21 in complex with R-caged GTP
3461:: CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH S-CAGED GTP
2676:
Harms KL, Chen X (May 2006). "p19ras brings a new twist to the regulation of p73 by Mdm2".
2006:
binds and HRAS-GTP dissociates from the GEF, resulting in HRAS activation. HRAS is in the
1966:
and is an early player in many signal transduction pathways and is usually associated with
6263:
6258:
6019:
6014:
5990:
5985:
5951:
5848:
5776:
5600:
5342:
5231:
5045:
4745:
4565:
4493:
2526:
McCormick F (Dec 1995). "Ras-related proteins in signal transduction and growth control".
1915:
1907:
1112:
915:
691:
3026:: H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'- TRIPHOSPHATE AND MANGANESE
3011:: H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'- TRIPHOSPHATE AND MAGNESIUM
2474:
K. M. Reily; D. A. Loisel; R. T. Bronson; M. E. McLaughlin; T. Jacks (September 2000). "
2432:
2240:
5962:
4665:
4296:
3666:
3506:: CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GDP (2)
3491:: CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP (2)
2659:
2634:
2451:
2416:
2392:
2367:
2091:
2075:
1967:
1951:
3446:: CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GPPNHP
1486:
1481:
1476:
1471:
1466:
1461:
1456:
1451:
1446:
1441:
1436:
1431:
1426:
1421:
1416:
1411:
1406:
1401:
1396:
1391:
1386:
1381:
1376:
1371:
1366:
1361:
1356:
1351:
1346:
1341:
1336:
1331:
1326:
1321:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1179:
1174:
1169:
1164:
1159:
1154:
46:
6464:
6041:
5980:
5853:
5209:
4819:
4446:
4148:
4122:
3718:
2007:
1947:
1911:
1141:
30:
This article is about the gene and protein it encodes. For the singular of HRAs, see
2705:
2625:
2592:
2507:
2352:
5997:
5835:
5194:
5167:
5096:
5089:
5072:
5067:
5041:
4209:
3969:
3476:: CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP
3431:: CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GDP
2555:
2078:. When mutated, proto-oncogenes have the potential to cause normal cells to become
2002:, which forces the release of bound nucleotide. Subsequently, GTP present in the
1919:
933:
712:
675:
2441:
2336:
2272:"A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere"
699:
5900:
5470:
5290:
4064:
3780:
2214:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2196:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2129:
1983:
2996:: Crystal Structure of the C-HA-RAS Protein Prepared by the Cell-Free Synthesis
2609:
2128:
is included in a genome-wide pattern, which was found to be correlated with an
1016:
6090:
5885:
5562:
5275:
4964:
4345:
4292:
4274:
4218:
2720:
2576:
2383:
2050:
1975:
1927:
832:
729:
679:
6412:
2689:
6354:
5567:
5485:
4981:
4540:
2478:
mutant mice develop glioblastoma with evidence of strain-specific effects".
2248:
2154:
ENSG00000174775 GRCh38: Ensembl release 89: ENSG00000276536, ENSG00000174775
2079:
1971:
1959:
1903:
1516:
1076:
954:
899:
886:
798:
785:
687:
2697:
2668:
2650:
2617:
2584:
2539:
2499:
2460:
2401:
2344:
2287:
2547:
2295:
2256:
1862:
1857:
4498:
4243:
4238:
3876:
3701:
2038:
1846:
1665:
1646:
6432:
6156:
6002:
5386:
5355:
5133:
5128:
4887:
4877:
4852:
4847:
4582:
2095:
2053:
2003:
1632:
1583:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
6437:
6225:
6220:
5930:
5263:
4905:
4882:
4872:
4842:
4837:
4832:
4827:
4784:
4774:
4769:
4764:
4759:
4728:
4716:
4711:
4706:
4701:
4689:
4684:
4679:
4628:
4278:
4191:
2099:
2057:
1995:
1963:
1882:
1830:
1538:
17:
2563:
Ayllón V, Rebollo A (2001). "Ras-induced cellular events (review)".
2271:
1946:
GTPase HRas is involved in regulating cell division in response to
6235:
6230:
6192:
6177:
6144:
6139:
6100:
6095:
6083:
6078:
6073:
6068:
6056:
6034:
6029:
6024:
5801:
5796:
5791:
5786:
5746:
5741:
5679:
5674:
5669:
5664:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5319:
5258:
5241:
5236:
5084:
5062:
5028:
5023:
5008:
4986:
4974:
4969:
4959:
4954:
4949:
4674:
4650:
4488:
4405:
4400:
4316:
4311:
4132:
3927:
3922:
3888:
3881:
3809:
2491:
1979:
1931:
2801:: HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE
2310:"Entrez Gene: v-Ha-ras Harvey rat sarcoma viral oncogene homolog"
1501:
1497:
6417:
6402:
6187:
6127:
6122:
6117:
6112:
6051:
6046:
5890:
5863:
5771:
5766:
5761:
5756:
5751:
5728:
5723:
5718:
5713:
5708:
5659:
5654:
5644:
5324:
5280:
5268:
5253:
5219:
5199:
5182:
5177:
5172:
5160:
5155:
5150:
5140:
5116:
5111:
5106:
5101:
5003:
4468:
4463:
4428:
4350:
3867:
2011:
1999:
1891:
667:
5405:
4513:
3670:
3356:: Crystal Structure of the GDP-bound form of the RasG60A mutant
3296:: H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
2846:: H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
2739:
1121:
5374:
5370:
4412:
4269:
4259:
4048:
2735:
6451:
deficiencies of intracellular signaling peptides and proteins
3416:: STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS
3371:: Structure of the Q61G mutant of Ras in the GDP-bound form
3326:: Crystal structure of the GppNHp-bound H-Ras G60A mutant
1432:
positive regulation of transcription by RNA polymerase II
3341:: Crystal Structure of a ternary Ras:SOS:Ras*GDP complex
1417:
positive regulation of actin cytoskeleton reorganization
923:
2010:
family, which also includes two other proto-oncogenes:
2368:"HRAS mutations in epithelial-myoepithelial carcinoma"
1322:
positive regulation of Ras protein signal transduction
2906:: STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K
1088:
3386:: Crystal Structure of the GTP-bound form of RasQ61G
3071:: Crystal Structure of RasA59G in the GDP-bound Form
3056:: Crystal Structure of RasA59G in the GTP-bound form
2028:
List of genes mutated in pigmented cutaneous lesions
1482:
positive regulation of protein targeting to membrane
1427:
negative regulation of cell population proliferation
1382:
positive regulation of cell population proliferation
1332:
stimulatory C-type lectin receptor signaling pathway
1292:
positive regulation of epithelial cell proliferation
1272:
regulation of long-term neuronal synaptic plasticity
6395:
6374:
6353:
6333:
6305:
6286:
6276:
6251:
6208:
6167:
5970:
5960:
5939:
5913:
5834:
5552:
5502:
5493:
5484:
5458:
5439:
5340:
5299:
5039:
4913:
4900:
4865:
4817:
4798:
4744:
4664:
4643:
4636:
4619:
4596:
4556:
4481:
4454:
4445:
4421:
4388:
4379:
4359:
4338:
4329:
4304:
4291:
4252:
4226:
4217:
4208:
4184:
4168:
4161:
4141:
4115:
4106:
4086:
4077:
4057:
4041:
4032:
4007:
3998:
3978:
3962:
3953:
3944:
3915:
3906:
3860:
3851:
3831:
3822:
3802:
3793:
3773:
3764:
3755:
3726:
3717:
3708:
1783:
1750:
1716:
1683:
1027:
dentate gyrus of hippocampal formation granule cell
6325:Sh2 domain-containing protein tyrosine phosphatase
3281:: STRUCTURE OF P21RAS IN COMPLEX WITH GTP AT 100 K
2721:GeneReviews/NCBI/NIH/UW entry on Costello syndrome
2170:
2168:
2166:
2149:
2147:
2145:
1327:positive regulation of interferon-gamma production
1877:, from "Harvey Rat sarcoma virus", also known as
870:
769:
2090:gene in bladder cells have been associated with
2086:and are not inherited. Somatic mutations in the
1472:positive regulation of phospholipase C activity
1257:negative regulation of neuron apoptotic process
2366:Chiosea SI, Miller M, Seethala RR (Jun 2014).
2175:GRCm38: Ensembl release 89: ENSMUSG00000025499
1287:positive regulation of miRNA metabolic process
1267:positive regulation of protein phosphorylation
5433:Intracellular signaling peptides and proteins
5417:
4525:
3682:
2751:
8:
1387:positive regulation of ERK1 and ERK2 cascade
6320:Receptor-like protein tyrosine phosphatase
6283:
5967:
5499:
5490:
5424:
5410:
5402:
4910:
4640:
4633:
4532:
4518:
4510:
4451:
4385:
4335:
4301:
4223:
4214:
4165:
4112:
4083:
4038:
4004:
3959:
3950:
3912:
3857:
3828:
3799:
3770:
3761:
3723:
3714:
3689:
3675:
3667:
3041:: Crystal structure of Ras-Bry2RBD complex
2758:
2744:
2736:
2325:The American Journal of Surgical Pathology
1512:
1282:positive regulation of MAP kinase activity
1137:
911:
810:
707:
81:
5921:Cyclin-dependent kinase inhibitor protein
3161:: H-Ras 166 in 50% 2,2,2 triflouroethanol
2831:: COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1
2728:at the U.S. National Library of Medicine
2658:
2450:
2440:
2391:
2045:gene have been identified in people with
1447:small GTPase mediated signal transduction
1047:fetal liver hematopoietic progenitor cell
6428:Phosphatidylethanolamine binding protein
6064:Interleukin-1 receptor associated kinase
5476:Ca2+/calmodulin-dependent protein kinase
3176:: H-Ras 166 in Aqueous mother liquor, RT
1906:522,241 to base pair 525,549. HRas is a
1898:gene is located on the short (p) arm of
1211:intracellular membrane-bounded organelle
3206:: H-RAS 166 in 60 % 1,6 hexanediol
2773:
2415:K. A. Aiello; O. Alter (October 2016).
2141:
1367:cell surface receptor signaling pathway
1302:mitotic cell cycle checkpoint signaling
6183:Focal adhesion protein-tyrosine kinase
5466:Intracellular calcium-sensing proteins
2966:: RAS G12V - PI 3-KINASE GAMMA COMPLEX
2528:Molecular Reproduction and Development
1467:positive regulation of DNA replication
1377:negative regulation of GTPase activity
1372:positive regulation of gene expression
1357:positive regulation of GTPase activity
1342:negative regulation of gene expression
1297:positive regulation of ruffle assembly
36:
1352:intrinsic apoptotic signaling pathway
1307:positive regulation of cell migration
875:
836:
831:
774:
733:
728:
7:
1462:cellular response to gamma radiation
1317:positive regulation of wound healing
1422:positive regulation of MAPK cascade
6408:Signal transducing adaptor protein
5583:3',5'-cyclic-GMP phosphodiesterase
5539:3',5'-cyclic-AMP phosphodiesterase
1780:
1747:
1713:
1680:
1656:
1637:
1611:
1588:
1562:
1543:
1337:positive regulation of JNK cascade
1093:
1011:
949:
928:
25:
6403:Activating transcription factor 6
5817:G protein-coupled receptor kinase
1885:that in humans is encoded by the
1412:T cell receptor signaling pathway
1312:ephrin receptor signaling pathway
5947:Phosphoinositide phospholipase C
3646:
3631:
3616:
3601:
3586:
3571:
3556:
3541:
3526:
3511:
3496:
3481:
3466:
3451:
3436:
3421:
3406:
3391:
3376:
3361:
3346:
3331:
3316:
3301:
3286:
3271:
3256:
3241:
3226:
3211:
3196:
3181:
3166:
3151:
3136:
3121:
3106:
3091:
3076:
3061:
3046:
3031:
3016:
3001:
2986:
2971:
2956:
2941:
2926:
2911:
2896:
2881:
2866:
2851:
2836:
2821:
2806:
2791:
2776:
1111:
1104:
1097:
859:
852:
846:
823:
758:
751:
745:
720:
45:
1402:Ras protein signal transduction
1397:T-helper 1 type immune response
1231:perinuclear region of cytoplasm
6386:GTP-binding protein regulators
6376:GTP-binding protein regulators
1122:More reference expression data
1077:More reference expression data
997:right hemisphere of cerebellum
1:
6135:Rho-associated protein kinase
1477:protein heterooligomerization
1407:cell population proliferation
1262:defense response to protozoan
844:
743:
27:Protein-coding gene in humans
6471:Genes on human chromosome 11
6341:Dual-specificity phosphatase
6316:protein tyrosine phosphatase
5822:AMP-activated protein kinase
3946:Intracellular signaling P+Ps
2442:10.1371/journal.pone.0164546
2337:10.1097/PAS.0000000000000410
2074:HRAS has been shown to be a
1954:act by binding cell surface
1457:response to isolation stress
6365:apoptosis signaling pathway
5302:Protein-synthesizing GTPase
6492:
4000:TGF beta signaling pathway
3908:JAK-STAT signaling pathway
3824:TGF beta signaling pathway
3795:Hedgehog signaling pathway
3191:: H-Ras in 50% isopropanol
2610:10.1080/019262301753178474
2565:Molecular Membrane Biology
2025:
1970:due to the presence of an
1392:animal organ morphogenesis
1160:protein C-terminus binding
29:
6446:
6209:Serine/threonine/tyrosine
5812:
5695:
5596:
5361:Guanylate-binding protein
4545:acid anhydride hydrolases
4034:Akt/PKB signaling pathway
2771:
2639:British Journal of Cancer
2577:10.1080/09687680050117093
2384:10.1007/s12105-013-0506-4
2210:"Mouse PubMed Reference:"
2192:"Human PubMed Reference:"
2115:Somatic mutations in the
1861:
1856:
1852:
1845:
1829:
1823:Chr 7: 140.77 – 140.77 Mb
1810:
1787:
1754:
1743:
1720:
1687:
1676:
1663:
1659:
1644:
1640:
1631:
1618:
1614:
1595:
1591:
1582:
1569:
1565:
1550:
1546:
1537:
1522:
1515:
1511:
1495:
1140:
1136:
1119:
1096:
1087:
1074:
1023:
1014:
961:
952:
922:
914:
910:
893:
880:
843:
822:
813:
809:
792:
779:
742:
719:
710:
706:
661:
658:
648:
641:
636:
89:
84:
67:
62:
57:
53:
44:
39:
6423:Olfactory marker protein
6010:Glycogen synthase kinase
5513:Heterotrimeric G protein
4916:Heterotrimeric G protein
4611:Phosphoadenylylsulfatase
3853:Receptor tyrosine kinase
2730:Medical Subject Headings
2690:10.1126/stke.3372006pe24
2037:At least five inherited
1926:, H-Ras will activate a
1879:transforming protein p21
6216:Dual-specificity kinase
5926:Cyclin-dependent kinase
4588:Thiamine-triphosphatase
4079:Hippo signaling pathway
2372:Head and Neck Pathology
2249:10.1126/science.6264598
1934:, the next step in the
1902:at position 15.5, from
4094:Neurofibromin 2/Merlin
3698:Tumor suppressor genes
2651:10.1038/sj.bjc.6602258
2604:. 29 Suppl (5): 51–9.
2540:10.1002/mrd.1080420419
2288:10.1006/geno.1996.0367
1924:Guanosine triphosphate
1816:Chr 11: 0.53 – 0.54 Mb
1039:superior frontal gyrus
6297:Protein phosphatase 2
6108:p21-activated kinases
5343:Polymerization motors
5054:Rho family of GTPases
3955:Wnt signaling pathway
3766:Wnt signaling pathway
2602:Toxicologic Pathology
2022:Clinical significance
1241:glutamatergic synapse
736:Chromosome 11 (human)
5700:G beta-gamma complex
4381:Transcription factor
3311:: RAS-RASGAP COMPLEX
2098:with the amino acid
2056:with the amino acid
877:7 F5|7 86.48 cM
838:Chromosome 7 (mouse)
85:List of PDB id codes
58:Available structures
32:HRA (disambiguation)
6279:protein phosphatase
6152:Ribosomal s6 kinase
5351:dynamin superfamily
4456:Apoptosis inhibitor
3839:TGF beta receptor 2
2726:HRAS+protein,+human
2433:2016PLoSO..1164546A
2241:1981Sci...213..226W
1452:cellular senescence
1437:signal transduction
5449:MAP kinase pathway
1621:ENSMUSG00000025499
1250:Biological process
1189:Cellular component
1155:nucleotide binding
1148:Molecular function
6458:
6457:
6413:I-kappa B protein
6349:
6348:
6272:
6271:
5909:
5908:
5830:
5829:
5573:Guanylate cyclase
5529:Adenylate cyclase
5399:
5398:
5395:
5394:
4896:
4895:
4861:
4860:
4606:Adenylylsulfatase
4507:
4506:
4477:
4476:
4441:
4440:
4437:
4436:
4375:
4374:
4325:
4324:
4287:
4286:
4204:
4203:
4200:
4199:
4157:
4156:
4102:
4101:
4073:
4072:
4028:
4027:
3994:
3993:
3940:
3939:
3936:
3935:
3902:
3901:
3847:
3846:
3818:
3817:
3789:
3788:
3751:
3750:
3747:
3746:
3664:
3663:
2084:somatic mutations
2047:Costello syndrome
2033:Costello syndrome
1986:. HRAS binds to
1872:
1871:
1868:
1867:
1841:
1840:
1806:
1805:
1777:
1776:
1739:
1738:
1710:
1709:
1672:
1671:
1653:
1652:
1627:
1626:
1608:
1607:
1578:
1577:
1559:
1558:
1507:
1506:
1442:apoptotic process
1132:
1131:
1128:
1127:
1083:
1082:
1070:
1069:
1059:perirhinal cortex
1055:entorhinal cortex
1008:
1007:
981:nucleus accumbens
906:
905:
805:
804:
632:
631:
628:
627:
68:Ortholog search:
16:(Redirected from
6483:
6288:Serine/threonine
6284:
5972:Serine/threonine
5968:
5588:Protein kinase G
5544:Protein kinase A
5500:
5491:
5426:
5419:
5412:
5403:
4911:
4641:
4634:
4534:
4527:
4520:
4511:
4452:
4386:
4336:
4331:Ubiquitin ligase
4302:
4224:
4215:
4166:
4113:
4108:MAPK/ERK pathway
4084:
4039:
4005:
3960:
3951:
3913:
3858:
3829:
3800:
3771:
3762:
3724:
3715:
3691:
3684:
3677:
3668:
3650:
3635:
3620:
3605:
3590:
3575:
3560:
3545:
3530:
3515:
3500:
3485:
3470:
3455:
3440:
3425:
3410:
3395:
3380:
3365:
3350:
3335:
3320:
3305:
3290:
3275:
3260:
3245:
3230:
3215:
3200:
3185:
3170:
3155:
3140:
3125:
3110:
3095:
3080:
3065:
3050:
3035:
3020:
3005:
2990:
2975:
2960:
2945:
2930:
2915:
2900:
2885:
2870:
2855:
2840:
2825:
2810:
2795:
2780:
2760:
2753:
2746:
2737:
2709:
2672:
2662:
2629:
2596:
2559:
2512:
2511:
2471:
2465:
2464:
2454:
2444:
2427:(10): e0164546.
2412:
2406:
2405:
2395:
2363:
2357:
2356:
2320:
2314:
2313:
2306:
2300:
2299:
2267:
2261:
2260:
2224:
2218:
2217:
2206:
2200:
2199:
2188:
2182:
2172:
2161:
2151:
1936:MAPK/ERK pathway
1922:. Once bound to
1854:
1853:
1825:
1818:
1801:
1781:
1772:
1748:
1744:RefSeq (protein)
1734:
1714:
1705:
1681:
1657:
1638:
1612:
1589:
1563:
1544:
1513:
1138:
1124:
1115:
1108:
1101:
1094:
1079:
1019:
1017:Top expressed in
1012:
1001:substantia nigra
957:
955:Top expressed in
950:
929:
912:
902:
889:
878:
863:
856:
850:
839:
827:
811:
801:
788:
777:
762:
755:
749:
738:
724:
708:
702:
700:HRAS - orthologs
653:
646:
623:
82:
76:
55:
54:
49:
37:
21:
6491:
6490:
6486:
6485:
6484:
6482:
6481:
6480:
6461:
6460:
6459:
6454:
6442:
6391:
6370:
6345:
6329:
6301:
6268:
6259:Arginine kinase
6247:
6204:
6163:
5956:
5952:Phospholipase C
5935:
5905:
5826:
5808:
5738:
5705:
5691:
5606:
5601:G alpha subunit
5592:
5548:
5480:
5454:
5435:
5430:
5400:
5391:
5336:
5295:
5046:Ras superfamily
5035:
5019:
4999:
4945:
4935:
4927:
4892:
4857:
4813:
4794:
4740:
4697:Plasma membrane
4660:
4615:
4592:
4566:Pyrophosphatase
4552:
4538:
4508:
4503:
4482:Other/ungrouped
4473:
4433:
4417:
4371:
4355:
4321:
4283:
4248:
4196:
4180:
4153:
4149:Neurofibromin 1
4137:
4098:
4069:
4053:
4024:
3990:
3974:
3932:
3898:
3843:
3814:
3785:
3743:
3704:
3695:
3665:
3660:
3657:
3651:
3642:
3636:
3627:
3621:
3612:
3606:
3597:
3591:
3582:
3576:
3567:
3561:
3552:
3546:
3537:
3531:
3522:
3516:
3507:
3501:
3492:
3486:
3477:
3471:
3462:
3456:
3447:
3441:
3432:
3426:
3417:
3411:
3402:
3396:
3387:
3381:
3372:
3366:
3357:
3351:
3342:
3336:
3327:
3321:
3312:
3306:
3297:
3291:
3282:
3276:
3267:
3261:
3252:
3246:
3237:
3231:
3222:
3216:
3207:
3201:
3192:
3186:
3177:
3171:
3162:
3156:
3147:
3141:
3132:
3126:
3117:
3111:
3102:
3096:
3087:
3081:
3072:
3066:
3057:
3051:
3042:
3036:
3027:
3021:
3012:
3006:
2997:
2991:
2982:
2976:
2967:
2961:
2952:
2946:
2937:
2931:
2922:
2916:
2907:
2901:
2892:
2886:
2877:
2871:
2862:
2856:
2847:
2841:
2832:
2826:
2817:
2811:
2802:
2796:
2787:
2781:
2767:
2764:
2717:
2712:
2675:
2632:
2599:
2562:
2525:
2521:
2519:Further reading
2516:
2515:
2480:Nature Genetics
2473:
2472:
2468:
2414:
2413:
2409:
2365:
2364:
2360:
2322:
2321:
2317:
2308:
2307:
2303:
2269:
2268:
2264:
2235:(4504): 226–8.
2226:
2225:
2221:
2208:
2207:
2203:
2190:
2189:
2185:
2173:
2164:
2152:
2143:
2138:
2113:
2072:
2035:
2030:
2024:
1944:
1916:Ras superfamily
1908:small G protein
1863:View/Edit Mouse
1858:View/Edit Human
1821:
1814:
1811:Location (UCSC)
1797:
1793:
1789:
1768:
1764:
1760:
1756:
1730:
1726:
1722:
1701:
1697:
1693:
1689:
1602:ENSG00000174775
1600:
1598:ENSG00000276536
1491:
1245:
1226:plasma membrane
1206:Golgi apparatus
1184:
1170:GTPase activity
1165:protein binding
1120:
1110:
1109:
1103:
1102:
1075:
1066:
1063:muscle of thigh
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1015:
1004:
999:
995:
991:
987:
983:
979:
977:caudate nucleus
975:
971:
967:
965:skin of abdomen
953:
897:
884:
876:
866:
865:
864:
857:
837:
814:Gene location (
796:
783:
775:
765:
764:
763:
756:
734:
711:Gene location (
662:
649:
642:
91:
69:
35:
28:
23:
22:
15:
12:
11:
5:
6489:
6487:
6479:
6478:
6473:
6463:
6462:
6456:
6455:
6447:
6444:
6443:
6441:
6440:
6435:
6430:
6425:
6420:
6415:
6410:
6405:
6399:
6397:
6393:
6392:
6390:
6389:
6380:
6378:
6372:
6371:
6369:
6368:
6359:
6357:
6351:
6350:
6347:
6346:
6344:
6343:
6337:
6335:
6331:
6330:
6328:
6327:
6322:
6312:
6310:
6303:
6302:
6300:
6299:
6293:
6291:
6281:
6274:
6273:
6270:
6269:
6267:
6266:
6261:
6255:
6253:
6249:
6248:
6246:
6245:
6244:
6243:
6238:
6233:
6228:
6223:
6212:
6210:
6206:
6205:
6203:
6202:
6197:
6196:
6195:
6190:
6180:
6174:
6172:
6165:
6164:
6162:
6161:
6160:
6159:
6149:
6148:
6147:
6142:
6132:
6131:
6130:
6125:
6120:
6115:
6105:
6104:
6103:
6098:
6088:
6087:
6086:
6081:
6076:
6071:
6061:
6060:
6059:
6054:
6049:
6039:
6038:
6037:
6032:
6027:
6022:
6017:
6007:
6006:
6005:
5995:
5994:
5993:
5988:
5977:
5975:
5965:
5963:protein kinase
5958:
5957:
5955:
5954:
5949:
5943:
5941:
5937:
5936:
5934:
5933:
5928:
5923:
5917:
5915:
5911:
5910:
5907:
5906:
5904:
5903:
5898:
5893:
5888:
5883:
5878:
5873:
5872:
5871:
5866:
5861:
5851:
5846:
5840:
5838:
5832:
5831:
5828:
5827:
5825:
5824:
5819:
5813:
5810:
5809:
5807:
5806:
5805:
5804:
5799:
5794:
5789:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5736:
5733:
5732:
5731:
5726:
5721:
5716:
5711:
5703:
5696:
5693:
5692:
5690:
5689:
5688:
5687:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5647:
5642:
5637:
5632:
5627:
5622:
5617:
5612:
5604:
5597:
5594:
5593:
5591:
5590:
5585:
5580:
5575:
5570:
5565:
5559:
5557:
5550:
5549:
5547:
5546:
5541:
5536:
5531:
5526:
5525:
5524:
5509:
5507:
5497:
5495:Heterotrimeric
5488:
5482:
5481:
5479:
5478:
5473:
5468:
5462:
5460:
5456:
5455:
5453:
5452:
5443:
5441:
5437:
5436:
5431:
5429:
5428:
5421:
5414:
5406:
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5393:
5392:
5390:
5389:
5384:
5383:
5382:
5377:
5368:
5363:
5358:
5347:
5345:
5338:
5337:
5335:
5334:
5329:
5328:
5327:
5322:
5317:
5306:
5304:
5297:
5296:
5294:
5293:
5288:
5283:
5278:
5273:
5272:
5271:
5266:
5261:
5256:
5246:
5245:
5244:
5239:
5229:
5228:
5227:
5222:
5217:
5205:
5204:
5203:
5202:
5197:
5187:
5186:
5185:
5180:
5175:
5165:
5164:
5163:
5158:
5153:
5143:
5138:
5137:
5136:
5131:
5121:
5120:
5119:
5114:
5109:
5104:
5094:
5093:
5092:
5087:
5077:
5076:
5075:
5070:
5065:
5050:
5048:
5037:
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5034:
5033:
5032:
5031:
5026:
5017:
5013:
5012:
5011:
5006:
4997:
4993:
4992:
4991:
4990:
4989:
4979:
4978:
4977:
4972:
4962:
4957:
4952:
4943:
4939:
4938:
4937:
4933:
4925:
4920:
4918:
4908:
4898:
4897:
4894:
4893:
4891:
4890:
4885:
4880:
4875:
4869:
4867:
4863:
4862:
4859:
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4796:
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4792:
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4782:
4777:
4772:
4767:
4762:
4757:
4751:
4749:
4742:
4741:
4739:
4738:
4737:
4736:
4731:
4721:
4720:
4719:
4714:
4709:
4704:
4694:
4693:
4692:
4687:
4682:
4671:
4669:
4662:
4661:
4659:
4658:
4653:
4647:
4645:
4644:Cu++ (3.6.3.4)
4638:
4631:
4617:
4616:
4614:
4613:
4608:
4602:
4600:
4594:
4593:
4591:
4590:
4585:
4580:
4579:
4578:
4573:
4562:
4560:
4554:
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4539:
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4529:
4522:
4514:
4505:
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4502:
4501:
4496:
4491:
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4483:
4479:
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4466:
4460:
4458:
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4431:
4425:
4423:
4419:
4418:
4416:
4415:
4410:
4409:
4408:
4403:
4392:
4390:
4383:
4377:
4376:
4373:
4372:
4370:
4369:
4363:
4361:
4357:
4356:
4354:
4353:
4348:
4342:
4340:
4333:
4327:
4326:
4323:
4322:
4320:
4319:
4314:
4308:
4306:
4299:
4289:
4288:
4285:
4284:
4282:
4281:
4272:
4267:
4262:
4256:
4254:
4250:
4249:
4247:
4246:
4241:
4236:
4230:
4228:
4221:
4212:
4206:
4205:
4202:
4201:
4198:
4197:
4195:
4194:
4188:
4186:
4182:
4181:
4179:
4178:
4172:
4170:
4163:
4159:
4158:
4155:
4154:
4152:
4151:
4145:
4143:
4139:
4138:
4136:
4135:
4130:
4125:
4119:
4117:
4110:
4104:
4103:
4100:
4099:
4097:
4096:
4090:
4088:
4081:
4075:
4074:
4071:
4070:
4068:
4067:
4061:
4059:
4055:
4054:
4052:
4051:
4045:
4043:
4036:
4030:
4029:
4026:
4025:
4023:
4022:
4017:
4011:
4009:
4002:
3996:
3995:
3992:
3991:
3989:
3988:
3982:
3980:
3976:
3975:
3973:
3972:
3966:
3964:
3957:
3948:
3942:
3941:
3938:
3937:
3934:
3933:
3931:
3930:
3925:
3919:
3917:
3910:
3904:
3903:
3900:
3899:
3897:
3896:
3891:
3886:
3885:
3884:
3879:
3864:
3862:
3855:
3849:
3848:
3845:
3844:
3842:
3841:
3835:
3833:
3826:
3820:
3819:
3816:
3815:
3813:
3812:
3806:
3804:
3797:
3791:
3790:
3787:
3786:
3784:
3783:
3777:
3775:
3768:
3759:
3753:
3752:
3749:
3748:
3745:
3744:
3742:
3741:
3736:
3730:
3728:
3721:
3719:Growth factors
3712:
3706:
3705:
3696:
3694:
3693:
3686:
3679:
3671:
3662:
3661:
3659:
3658:
3652:
3645:
3643:
3637:
3630:
3628:
3622:
3615:
3613:
3607:
3600:
3598:
3592:
3585:
3583:
3577:
3570:
3568:
3562:
3555:
3553:
3547:
3540:
3538:
3532:
3525:
3523:
3517:
3510:
3508:
3502:
3495:
3493:
3487:
3480:
3478:
3472:
3465:
3463:
3457:
3450:
3448:
3442:
3435:
3433:
3427:
3420:
3418:
3412:
3405:
3403:
3397:
3390:
3388:
3382:
3375:
3373:
3367:
3360:
3358:
3352:
3345:
3343:
3337:
3330:
3328:
3322:
3315:
3313:
3307:
3300:
3298:
3292:
3285:
3283:
3277:
3270:
3268:
3262:
3255:
3253:
3247:
3240:
3238:
3232:
3225:
3223:
3217:
3210:
3208:
3202:
3195:
3193:
3187:
3180:
3178:
3172:
3165:
3163:
3157:
3150:
3148:
3142:
3135:
3133:
3127:
3120:
3118:
3112:
3105:
3103:
3097:
3090:
3088:
3082:
3075:
3073:
3067:
3060:
3058:
3052:
3045:
3043:
3037:
3030:
3028:
3022:
3015:
3013:
3007:
3000:
2998:
2992:
2985:
2983:
2977:
2970:
2968:
2962:
2955:
2953:
2947:
2940:
2938:
2932:
2925:
2923:
2917:
2910:
2908:
2902:
2895:
2893:
2887:
2880:
2878:
2872:
2865:
2863:
2857:
2850:
2848:
2842:
2835:
2833:
2827:
2820:
2818:
2812:
2805:
2803:
2797:
2790:
2788:
2782:
2775:
2772:
2769:
2768:
2765:
2763:
2762:
2755:
2748:
2740:
2734:
2733:
2723:
2716:
2715:External links
2713:
2711:
2710:
2678:Science's STKE
2673:
2630:
2597:
2560:
2522:
2520:
2517:
2514:
2513:
2486:(1): 109–113.
2466:
2407:
2358:
2315:
2301:
2262:
2219:
2201:
2183:
2162:
2140:
2139:
2137:
2134:
2112:
2109:
2092:bladder cancer
2076:proto-oncogene
2071:
2070:Bladder cancer
2068:
2034:
2031:
2023:
2020:
1968:cell membranes
1952:Growth factors
1943:
1940:
1870:
1869:
1866:
1865:
1860:
1850:
1849:
1843:
1842:
1839:
1838:
1836:
1834:
1827:
1826:
1819:
1812:
1808:
1807:
1804:
1803:
1785:
1784:
1778:
1775:
1774:
1752:
1751:
1745:
1741:
1740:
1737:
1736:
1718:
1717:
1711:
1708:
1707:
1685:
1684:
1678:
1674:
1673:
1670:
1669:
1661:
1660:
1654:
1651:
1650:
1642:
1641:
1635:
1629:
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1625:
1624:
1616:
1615:
1609:
1606:
1605:
1593:
1592:
1586:
1580:
1579:
1576:
1575:
1567:
1566:
1560:
1557:
1556:
1548:
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1541:
1535:
1534:
1529:
1524:
1520:
1519:
1509:
1508:
1505:
1504:
1493:
1492:
1490:
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1253:
1251:
1247:
1246:
1244:
1243:
1238:
1233:
1228:
1223:
1221:Golgi membrane
1218:
1213:
1208:
1203:
1198:
1192:
1190:
1186:
1185:
1183:
1182:
1177:
1172:
1167:
1162:
1157:
1151:
1149:
1145:
1144:
1134:
1133:
1130:
1129:
1126:
1125:
1117:
1116:
1091:
1085:
1084:
1081:
1080:
1072:
1071:
1068:
1067:
1065:
1064:
1060:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1024:
1021:
1020:
1009:
1006:
1005:
1003:
1002:
998:
994:
990:
986:
982:
978:
974:
970:
966:
962:
959:
958:
946:
945:
937:
926:
920:
919:
916:RNA expression
908:
907:
904:
903:
895:
891:
890:
882:
879:
874:
868:
867:
858:
851:
845:
841:
840:
835:
829:
828:
820:
819:
807:
806:
803:
802:
794:
790:
789:
781:
778:
773:
767:
766:
757:
750:
744:
740:
739:
732:
726:
725:
717:
716:
704:
703:
660:
656:
655:
647:
639:
638:
634:
633:
630:
629:
626:
625:
87:
86:
78:
77:
66:
60:
59:
51:
50:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6488:
6477:
6474:
6472:
6469:
6468:
6466:
6453:
6452:
6445:
6439:
6436:
6434:
6431:
6429:
6426:
6424:
6421:
6419:
6416:
6414:
6411:
6409:
6406:
6404:
6401:
6400:
6398:
6394:
6388:
6387:
6382:
6381:
6379:
6377:
6373:
6367:
6366:
6361:
6360:
6358:
6356:
6352:
6342:
6339:
6338:
6336:
6332:
6326:
6323:
6321:
6317:
6314:
6313:
6311:
6308:
6304:
6298:
6295:
6294:
6292:
6289:
6285:
6282:
6280:
6275:
6265:
6262:
6260:
6257:
6256:
6254:
6250:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6218:
6217:
6214:
6213:
6211:
6207:
6201:
6198:
6194:
6191:
6189:
6186:
6185:
6184:
6181:
6179:
6176:
6175:
6173:
6170:
6166:
6158:
6155:
6154:
6153:
6150:
6146:
6143:
6141:
6138:
6137:
6136:
6133:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6110:
6109:
6106:
6102:
6099:
6097:
6094:
6093:
6092:
6089:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6066:
6065:
6062:
6058:
6055:
6053:
6050:
6048:
6045:
6044:
6043:
6040:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6018:
6016:
6013:
6012:
6011:
6008:
6004:
6001:
6000:
5999:
5996:
5992:
5989:
5987:
5984:
5983:
5982:
5981:Casein kinase
5979:
5978:
5976:
5973:
5969:
5966:
5964:
5959:
5953:
5950:
5948:
5945:
5944:
5942:
5938:
5932:
5929:
5927:
5924:
5922:
5919:
5918:
5916:
5912:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5874:
5870:
5867:
5865:
5862:
5860:
5857:
5856:
5855:
5852:
5850:
5847:
5845:
5842:
5841:
5839:
5837:
5833:
5823:
5820:
5818:
5815:
5814:
5811:
5803:
5800:
5798:
5795:
5793:
5790:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5739:
5734:
5730:
5727:
5725:
5722:
5720:
5717:
5715:
5712:
5710:
5707:
5706:
5701:
5698:
5697:
5694:
5686:
5683:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5607:
5602:
5599:
5598:
5595:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5571:
5569:
5566:
5564:
5561:
5560:
5558:
5555:
5551:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5523:
5519:
5516:
5515:
5514:
5511:
5510:
5508:
5505:
5501:
5498:
5496:
5492:
5489:
5487:
5483:
5477:
5474:
5472:
5469:
5467:
5464:
5463:
5461:
5457:
5451:
5450:
5445:
5444:
5442:
5438:
5434:
5427:
5422:
5420:
5415:
5413:
5408:
5407:
5404:
5388:
5385:
5381:
5378:
5376:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5353:
5352:
5349:
5348:
5346:
5344:
5339:
5333:
5330:
5326:
5323:
5321:
5318:
5316:
5313:
5312:
5311:
5308:
5307:
5305:
5303:
5298:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5251:
5250:
5247:
5243:
5240:
5238:
5235:
5234:
5233:
5230:
5226:
5223:
5221:
5218:
5216:
5213:
5212:
5211:
5207:
5206:
5201:
5198:
5196:
5193:
5192:
5191:
5188:
5184:
5181:
5179:
5176:
5174:
5171:
5170:
5169:
5166:
5162:
5159:
5157:
5154:
5152:
5149:
5148:
5147:
5144:
5142:
5139:
5135:
5132:
5130:
5127:
5126:
5125:
5122:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5100:
5099:
5098:
5095:
5091:
5088:
5086:
5083:
5082:
5081:
5078:
5074:
5071:
5069:
5066:
5064:
5061:
5060:
5059:
5055:
5052:
5051:
5049:
5047:
5043:
5038:
5030:
5027:
5025:
5022:
5021:
5020:
5014:
5010:
5007:
5005:
5002:
5001:
5000:
4994:
4988:
4985:
4984:
4983:
4980:
4976:
4973:
4971:
4968:
4967:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4947:
4946:
4940:
4936:
4930:
4929:
4928:
4922:
4921:
4919:
4917:
4912:
4909:
4907:
4903:
4899:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4870:
4868:
4864:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4825:
4823:
4821:
4820:P-type ATPase
4816:
4810:
4807:
4806:
4804:
4801:
4797:
4791:
4788:
4786:
4783:
4781:
4778:
4776:
4773:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4752:
4750:
4747:
4743:
4735:
4732:
4730:
4727:
4726:
4725:
4722:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4699:
4698:
4695:
4691:
4688:
4686:
4683:
4681:
4678:
4677:
4676:
4673:
4672:
4670:
4667:
4663:
4657:
4654:
4652:
4649:
4648:
4646:
4642:
4639:
4635:
4632:
4630:
4626:
4622:
4618:
4612:
4609:
4607:
4604:
4603:
4601:
4599:
4595:
4589:
4586:
4584:
4581:
4577:
4574:
4572:
4569:
4568:
4567:
4564:
4563:
4561:
4559:
4555:
4550:
4546:
4542:
4535:
4530:
4528:
4523:
4521:
4516:
4515:
4512:
4500:
4497:
4495:
4492:
4490:
4487:
4486:
4484:
4480:
4470:
4467:
4465:
4462:
4461:
4459:
4457:
4453:
4450:
4448:
4447:Mitochondrion
4444:
4430:
4427:
4426:
4424:
4420:
4414:
4411:
4407:
4404:
4402:
4399:
4398:
4397:
4394:
4393:
4391:
4387:
4384:
4382:
4378:
4368:
4365:
4364:
4362:
4358:
4352:
4349:
4347:
4344:
4343:
4341:
4337:
4334:
4332:
4328:
4318:
4315:
4313:
4310:
4309:
4307:
4303:
4300:
4298:
4294:
4290:
4280:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4257:
4255:
4251:
4245:
4242:
4240:
4237:
4235:
4232:
4231:
4229:
4225:
4222:
4220:
4216:
4213:
4211:
4207:
4193:
4190:
4189:
4187:
4183:
4177:
4174:
4173:
4171:
4167:
4164:
4162:Other/unknown
4160:
4150:
4147:
4146:
4144:
4140:
4134:
4131:
4129:
4126:
4124:
4121:
4120:
4118:
4114:
4111:
4109:
4105:
4095:
4092:
4091:
4089:
4085:
4082:
4080:
4076:
4066:
4063:
4062:
4060:
4056:
4050:
4047:
4046:
4044:
4040:
4037:
4035:
4031:
4021:
4018:
4016:
4013:
4012:
4010:
4006:
4003:
4001:
3997:
3987:
3984:
3983:
3981:
3977:
3971:
3968:
3967:
3965:
3961:
3958:
3956:
3952:
3949:
3947:
3943:
3929:
3926:
3924:
3921:
3920:
3918:
3914:
3911:
3909:
3905:
3895:
3892:
3890:
3887:
3883:
3880:
3878:
3875:
3874:
3873:
3869:
3866:
3865:
3863:
3859:
3856:
3854:
3850:
3840:
3837:
3836:
3834:
3830:
3827:
3825:
3821:
3811:
3808:
3807:
3805:
3801:
3798:
3796:
3792:
3782:
3779:
3778:
3776:
3772:
3769:
3767:
3763:
3760:
3758:
3754:
3740:
3737:
3735:
3732:
3731:
3729:
3725:
3722:
3720:
3716:
3713:
3711:
3707:
3703:
3699:
3692:
3687:
3685:
3680:
3678:
3673:
3672:
3669:
3655:
3649:
3644:
3640:
3634:
3629:
3625:
3619:
3614:
3610:
3604:
3599:
3595:
3589:
3584:
3580:
3574:
3569:
3565:
3559:
3554:
3550:
3544:
3539:
3535:
3529:
3524:
3520:
3514:
3509:
3505:
3499:
3494:
3490:
3484:
3479:
3475:
3469:
3464:
3460:
3454:
3449:
3445:
3439:
3434:
3430:
3424:
3419:
3415:
3409:
3404:
3400:
3394:
3389:
3385:
3379:
3374:
3370:
3364:
3359:
3355:
3349:
3344:
3340:
3334:
3329:
3325:
3319:
3314:
3310:
3304:
3299:
3295:
3289:
3284:
3280:
3274:
3269:
3265:
3259:
3254:
3250:
3244:
3239:
3235:
3229:
3224:
3220:
3214:
3209:
3205:
3199:
3194:
3190:
3184:
3179:
3175:
3169:
3164:
3160:
3154:
3149:
3145:
3139:
3134:
3130:
3124:
3119:
3115:
3109:
3104:
3100:
3094:
3089:
3085:
3079:
3074:
3070:
3064:
3059:
3055:
3049:
3044:
3040:
3034:
3029:
3025:
3019:
3014:
3010:
3004:
2999:
2995:
2989:
2984:
2980:
2974:
2969:
2965:
2959:
2954:
2950:
2944:
2939:
2935:
2929:
2924:
2920:
2914:
2909:
2905:
2899:
2894:
2890:
2884:
2879:
2875:
2869:
2864:
2860:
2854:
2849:
2845:
2839:
2834:
2830:
2824:
2819:
2815:
2809:
2804:
2800:
2794:
2789:
2785:
2779:
2774:
2770:
2761:
2756:
2754:
2749:
2747:
2742:
2741:
2738:
2731:
2727:
2724:
2722:
2719:
2718:
2714:
2707:
2703:
2699:
2695:
2691:
2687:
2684:(337): pe24.
2683:
2679:
2674:
2670:
2666:
2661:
2656:
2652:
2648:
2644:
2640:
2636:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2603:
2598:
2594:
2590:
2586:
2582:
2578:
2574:
2570:
2566:
2561:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2524:
2523:
2518:
2509:
2505:
2501:
2497:
2493:
2492:10.1038/79075
2489:
2485:
2481:
2477:
2470:
2467:
2462:
2458:
2453:
2448:
2443:
2438:
2434:
2430:
2426:
2422:
2418:
2411:
2408:
2403:
2399:
2394:
2389:
2385:
2381:
2378:(2): 146–50.
2377:
2373:
2369:
2362:
2359:
2354:
2350:
2346:
2342:
2338:
2334:
2331:(6): 744–52.
2330:
2326:
2319:
2316:
2311:
2305:
2302:
2297:
2293:
2289:
2285:
2282:(2): 353–60.
2281:
2277:
2273:
2266:
2263:
2258:
2254:
2250:
2246:
2242:
2238:
2234:
2230:
2223:
2220:
2215:
2211:
2205:
2202:
2197:
2193:
2187:
2184:
2180:
2176:
2171:
2169:
2167:
2163:
2159:
2155:
2150:
2148:
2146:
2142:
2135:
2133:
2131:
2127:
2123:
2118:
2111:Other cancers
2110:
2108:
2106:
2101:
2097:
2093:
2089:
2085:
2081:
2077:
2069:
2067:
2064:
2059:
2055:
2052:
2048:
2044:
2040:
2032:
2029:
2021:
2019:
2017:
2013:
2009:
2005:
2001:
1997:
1993:
1989:
1985:
1981:
1977:
1974:group on its
1973:
1969:
1965:
1961:
1957:
1953:
1950:stimulation.
1949:
1948:growth factor
1941:
1939:
1937:
1933:
1929:
1925:
1921:
1920:small GTPases
1917:
1913:
1912:Ras subfamily
1909:
1905:
1901:
1900:chromosome 11
1897:
1893:
1890:
1889:
1884:
1880:
1876:
1864:
1859:
1855:
1851:
1848:
1844:
1837:
1835:
1832:
1828:
1824:
1820:
1817:
1813:
1809:
1802:
1800:
1796:
1792:
1786:
1782:
1779:
1773:
1771:
1767:
1763:
1759:
1753:
1749:
1746:
1742:
1735:
1733:
1729:
1725:
1719:
1715:
1712:
1706:
1704:
1700:
1696:
1692:
1686:
1682:
1679:
1677:RefSeq (mRNA)
1675:
1668:
1667:
1662:
1658:
1655:
1649:
1648:
1643:
1639:
1636:
1634:
1630:
1623:
1622:
1617:
1613:
1610:
1604:
1603:
1599:
1594:
1590:
1587:
1585:
1581:
1574:
1573:
1568:
1564:
1561:
1555:
1554:
1549:
1545:
1542:
1540:
1536:
1533:
1530:
1528:
1525:
1521:
1518:
1514:
1510:
1503:
1499:
1494:
1488:
1485:
1483:
1480:
1478:
1475:
1473:
1470:
1468:
1465:
1463:
1460:
1458:
1455:
1453:
1450:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1385:
1383:
1380:
1378:
1375:
1373:
1370:
1368:
1365:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1345:
1343:
1340:
1338:
1335:
1333:
1330:
1328:
1325:
1323:
1320:
1318:
1315:
1313:
1310:
1308:
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1288:
1285:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1263:
1260:
1258:
1255:
1254:
1252:
1249:
1248:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1193:
1191:
1188:
1187:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1152:
1150:
1147:
1146:
1143:
1142:Gene ontology
1139:
1135:
1123:
1118:
1114:
1107:
1100:
1095:
1092:
1090:
1086:
1078:
1073:
1062:
1058:
1054:
1050:
1046:
1042:
1038:
1034:
1030:
1026:
1025:
1022:
1018:
1013:
1010:
1000:
996:
992:
989:temporal lobe
988:
984:
980:
976:
972:
968:
964:
963:
960:
956:
951:
948:
947:
944:
942:
938:
936:
935:
931:
930:
927:
925:
921:
917:
913:
909:
901:
896:
892:
888:
883:
873:
869:
862:
855:
849:
842:
834:
830:
826:
821:
817:
812:
808:
800:
795:
791:
787:
782:
772:
768:
761:
754:
748:
741:
737:
731:
727:
723:
718:
714:
709:
705:
701:
697:
693:
689:
685:
681:
677:
673:
669:
665:
657:
652:
645:
640:
635:
624:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
88:
83:
80:
79:
75:
72:
65:
61:
56:
52:
48:
43:
38:
33:
19:
6448:
6383:
6362:
5998:eIF-2 kinase
5858:
5446:
5214:
5189:
5123:
5079:
5057:
5042:Small GTPase
4656:Wilson/ATP7B
4651:Menkes/ATP7A
4127:
3970:Beta-catenin
3653:
3638:
3623:
3608:
3593:
3578:
3563:
3548:
3533:
3518:
3503:
3488:
3473:
3458:
3443:
3428:
3413:
3398:
3383:
3368:
3353:
3338:
3323:
3308:
3293:
3278:
3263:
3248:
3233:
3218:
3203:
3188:
3173:
3158:
3143:
3128:
3113:
3098:
3083:
3068:
3053:
3038:
3023:
3008:
2993:
2978:
2963:
2948:
2933:
2918:
2903:
2888:
2873:
2858:
2843:
2828:
2813:
2798:
2783:
2681:
2677:
2645:(1): 131–9.
2642:
2638:
2601:
2571:(2): 65–73.
2568:
2564:
2534:(4): 500–6.
2531:
2527:
2483:
2479:
2475:
2469:
2424:
2420:
2410:
2375:
2371:
2361:
2328:
2324:
2318:
2304:
2279:
2275:
2265:
2232:
2228:
2222:
2213:
2204:
2195:
2186:
2125:
2121:
2116:
2114:
2104:
2087:
2073:
2062:
2042:
2036:
1945:
1895:
1886:
1878:
1874:
1873:
1795:NP_001123916
1791:NP_001123915
1788:
1762:NP_001304983
1758:NP_001123914
1755:
1728:NM_001130444
1724:NM_001130443
1721:
1703:NM_001318054
1691:NM_001130442
1688:
1664:
1645:
1619:
1596:
1570:
1551:
1531:
1526:
1347:MAPK cascade
985:hypothalamus
939:
932:
898:140,773,918
885:140,769,018
659:External IDs
90:
5685:GNA15/GNA16
5471:Calcineurin
5366:Mitofusin-1
5341:3.6.5.5-6:
5310:Prokaryotic
2766:PDB gallery
2130:astrocytoma
1984:PI 3-kinase
1875:GTPase HRas
1277:endocytosis
1180:GDP binding
1175:GTP binding
969:skin of leg
637:Identifiers
6465:Categories
6091:Lim kinase
6042:IκB kinase
5563:Transducin
5332:Eukaryotic
4965:Transducin
4802:(3.6.3.10)
4541:Hydrolases
4293:DNA repair
4219:Cell cycle
3734:c-Sis/PDGF
2181:, May 2017
2160:, May 2017
2136:References
2051:amino acid
2026:See also:
1976:C-terminus
1928:Raf kinase
1362:chemotaxis
943:(ortholog)
680:HomoloGene
6476:Oncogenes
6449:see also
6355:Apoptosis
5836:Monomeric
5568:Gustducin
5486:G protein
5300:3.6.5.3:
5040:3.6.5.2:
4982:Gustducin
4914:3.6.5.1:
4748:(3.6.3.9)
4668:(3.6.3.8)
4571:Inorganic
3702:Oncogenes
2476:Nf1;Trp53
2080:cancerous
2039:mutations
1972:isoprenyl
1960:cytoplasm
1956:receptors
1904:base pair
1799:NP_032310
1770:NP_789765
1766:NP_005334
1732:NM_008284
1699:NM_176795
1695:NM_005343
1517:Orthologs
1196:cytoplasm
1043:esophagus
688:GeneCards
6307:Tyrosine
6252:Arginine
6169:Tyrosine
4576:Thiamine
4499:Stathmin
4244:Cyclin E
4239:Cyclin D
3877:HER2/neu
3757:Receptor
2706:22706614
2698:16738062
2669:15597105
2626:20211777
2618:11695562
2593:84294021
2585:10989457
2508:23076620
2500:10973261
2461:27798635
2421:PLOS ONE
2402:24277618
2353:34106002
2345:25723113
2276:Genomics
2177:–
2156:–
1942:Function
1847:Wikidata
1496:Sources:
1216:membrane
1051:yolk sac
993:amygdala
797:537,321
784:532,242
6433:EDARADD
6418:Mucin-4
6157:RPS6KA1
6003:EIF2AK3
5459:Calcium
5387:Tubulin
5356:Dynamin
5208:other:
4888:Katanin
4878:Kinesin
4853:ATP13A3
4848:ATP13A2
4583:Apyrase
4489:c-Bcl-2
4297:Fanconi
4210:Nucleus
2660:2361730
2556:6507743
2548:8607982
2452:5087864
2429:Bibcode
2393:4022927
2296:8661149
2257:6264598
2237:Bibcode
2229:Science
2179:Ensembl
2158:Ensembl
2096:glycine
2054:glycine
2041:in the
2004:cytosol
1914:of the
1910:in the
1633:UniProt
1584:Ensembl
1523:Species
1502:QuickGO
1236:nucleus
1201:cytosol
973:putamen
918:pattern
776:11p15.5
644:Aliases
6438:PRKCSH
6277:Other
6226:DYRK1B
6221:DYRK1A
5961:Other
5931:Cyclin
5914:Cyclin
5264:ARL13B
5124:RhoBTB
5018:α12/13
4906:GTPase
4883:Myosin
4873:Dynein
4843:ATP12A
4838:ATP11B
4833:ATP10A
4828:ATP8B1
4818:Other
4790:ATP1B4
4785:ATP1B3
4780:ATP1B2
4775:ATP1B1
4770:ATP1A4
4765:ATP1A3
4760:ATP1A2
4755:ATP1A1
4746:Na+/K+
4734:ATP2C2
4729:ATP2C1
4717:ATP2B4
4712:ATP2B3
4707:ATP2B2
4702:ATP2B1
4690:ATP2A3
4685:ATP2A2
4680:ATP2A1
4629:ATPase
4279:p14arf
4192:Maspin
3872:c-ErbB
3710:Ligand
2732:(MeSH)
2704:
2696:
2667:
2657:
2624:
2616:
2591:
2583:
2554:
2546:
2506:
2498:
2459:
2449:
2400:
2390:
2351:
2343:
2294:
2255:
2100:valine
2058:serine
1996:RasGAP
1964:GTPase
1894:. The
1883:enzyme
1881:is an
1833:search
1831:PubMed
1666:Q61411
1647:P01112
1539:Entrez
1089:BioGPS
668:190020
6396:Other
6334:both:
6241:DYRK4
6236:DYRK3
6231:DYRK2
6193:PTK2B
6178:ZAP70
6145:ROCK2
6140:ROCK1
6101:LIMK2
6096:LIMK1
6084:IRAK4
6079:IRAK3
6074:IRAK2
6069:IRAK1
6057:IKBKG
6035:GSK3B
6030:GSK3A
6025:GSK-3
5940:Lipid
5891:Rhebs
5802:BSCL2
5797:GNG13
5792:GNG12
5787:GNG11
5782:GNG10
5747:GNGT2
5742:GNGT1
5680:GNA14
5675:GNA13
5670:GNA12
5665:GNA11
5640:GNAT3
5635:GNAT2
5630:GNAT1
5625:GNAI3
5620:GNAI2
5615:GNAI1
5610:GNAO1
5320:EF-Tu
5259:SAR1B
5242:RAB27
5237:RAB23
5190:RhoDF
5080:RhoUV
5063:CDC42
5058:Cdc42
5044:>
5029:GNA13
5024:GNA12
5009:GNA11
4998:αq/11
4987:GNAT3
4975:GNAT2
4970:GNAT1
4960:GNAI3
4955:GNAI2
4950:GNAI1
4902:3.6.5
4866:3.6.4
4809:ATP4A
4800:H+/K+
4675:SERCA
4637:3.6.3
4621:3.6.3
4598:3.6.2
4558:3.6.1
4494:Notch
4413:c-Myc
4406:c-Jun
4401:c-Fos
4317:BRCA2
4312:BRCA1
4176:c-Src
4133:c-Raf
4123:c-Ras
4049:c-Akt
4020:SMAD4
4015:SMAD2
3923:c-Kit
3894:c-Ret
3889:c-Met
3882:Her 3
3810:PTCH1
2702:S2CID
2622:S2CID
2589:S2CID
2552:S2CID
2504:S2CID
2349:S2CID
1980:c-Raf
1932:c-Raf
1930:like
1572:15461
1532:Mouse
1527:Human
1498:Amigo
1035:molar
941:Mouse
934:Human
881:Start
816:Mouse
780:Start
713:Human
684:55890
676:96224
18:H-Ras
6384:see
6363:see
6264:McsB
6188:PTK2
6128:PAK4
6123:PAK3
6118:PAK2
6113:PAK1
6052:IKK2
6047:CHUK
6020:GSK2
6015:GSK1
5901:RGKs
5896:Raps
5881:Arfs
5876:Rhos
5869:NRAS
5864:KRAS
5859:HRAS
5849:Rabs
5844:ARFs
5777:GNG8
5772:GNG7
5767:GNG5
5762:GNG4
5757:GNG3
5752:GNG2
5729:GNB5
5724:GNB4
5719:GNB3
5714:GNB2
5709:GNB1
5660:GNAQ
5655:GNAL
5650:GNAS
5645:GNAZ
5578:cGMP
5554:cGMP
5534:cAMP
5504:cAMP
5447:see
5380:OPA1
5373:and
5325:EF-G
5315:IF-2
5281:Rheb
5269:ARL6
5254:ARF6
5225:NRAS
5220:KRAS
5215:HRAS
5200:RhoD
5195:RhoF
5141:RhoH
5117:RhoG
5102:Rac1
5090:RhoV
5085:RhoU
5068:TC10
5004:GNAQ
4724:SPCA
4551:3.6)
4469:SDHD
4464:SDHB
4429:KLF6
4396:AP-1
4389:ONCO
4351:MDM2
4339:ONCO
4234:CDK4
4227:ONCO
4169:ONCO
4128:HRAS
4116:ONCO
4065:PTEN
4042:ONCO
3963:ONCO
3928:Flt3
3916:ONCO
3868:ErbB
3861:ONCO
3781:CDH1
3727:ONCO
3700:and
3654:821p
3639:721p
3624:6q21
3609:621p
3594:5p21
3579:521p
3564:4q21
3549:421p
3534:2q21
3519:2evw
3504:2cld
3489:2clc
3474:2cl7
3459:2cl6
3444:2cl0
3429:2ce2
3414:2c5l
3399:221p
3384:1zw6
3369:1zvq
3354:1xj0
3339:1xd2
3324:1xcm
3309:1wq1
3294:1rvd
3279:1qra
3264:1q21
3249:1pll
3234:1plk
3219:1plj
3204:1p2v
3189:1p2u
3174:1p2t
3159:1p2s
3144:1nvx
3129:1nvw
3114:1nvv
3099:1nvu
3084:1lfd
3069:1lf5
3054:1lf0
3039:1k8r
3024:1jai
3009:1jah
2994:1ioz
2979:1iaq
2964:1he8
2949:1gnr
2934:1gnq
2919:1gnp
2904:1ctq
2889:1crr
2874:1crq
2859:1crp
2844:1clu
2829:1bkd
2814:1agp
2799:1aa9
2784:121p
2694:PMID
2682:2006
2665:PMID
2614:PMID
2581:PMID
2544:PMID
2496:PMID
2457:PMID
2398:PMID
2341:PMID
2292:PMID
2253:PMID
2126:HRAS
2122:HRAS
2117:HRAS
2105:HRAS
2088:HRAS
2063:HRAS
2043:HRAS
2016:NRAS
2014:and
2012:KRAS
2000:SOS1
1982:and
1896:HRAS
1892:gene
1888:HRAS
1553:3265
924:Bgee
872:Band
833:Chr.
771:Band
730:Chr.
692:HRAS
664:OMIM
651:HRAS
621:5B30
617:4RSG
613:4XVR
609:4XVQ
605:2N46
601:2N42
597:4US2
593:4US1
589:4US0
585:4URZ
581:4URY
577:4URX
573:4URW
569:4URV
565:4URU
561:4NYM
557:4NYJ
553:4NYI
549:4L9W
545:4L9S
541:821P
537:721P
533:6Q21
529:621P
525:5P21
521:521P
517:4Q21
513:4K81
509:4G3X
505:4G0N
501:4EFN
497:4EFM
493:4EFL
489:4DLZ
485:4DLY
481:4DLX
477:4DLW
473:4DLV
469:4DLU
465:4DLT
461:4DLS
457:4DLR
453:421P
449:3RSO
445:3RSL
441:3RS7
437:3RS5
433:3RS4
429:3RS3
425:3RS2
421:3RS0
417:3RRZ
413:3RRY
409:3OIW
405:3OIV
401:3OIU
397:3LO5
393:3LBN
389:3LBI
385:3LBH
381:3L8Z
377:3L8Y
373:3KUD
369:3KKN
365:3KKM
361:3K9N
357:3K9L
353:3K8Y
349:3I3S
345:3DDC
341:2X1V
337:2VH5
333:2UZI
329:2RGG
325:2RGE
321:2RGD
317:2RGC
313:2RGB
309:2RGA
305:2QUZ
301:2Q21
297:2LWI
293:2LCF
289:2EVW
285:2CLD
281:2CLC
277:2CL7
273:2CL6
269:2CL0
265:2CE2
261:2C5L
257:221P
253:1ZW6
249:1ZVQ
245:1XJ0
241:1XD2
237:1XCM
233:1WQ1
229:1RVD
225:1QRA
221:1Q21
217:1PLL
213:1PLK
209:1PLJ
205:1P2V
201:1P2U
197:1P2T
193:1P2S
189:1NVX
185:1NVW
181:1NVV
177:1NVU
173:1LFD
169:1LF5
165:1LF0
161:1K8R
157:1JAI
153:1JAH
149:1IOZ
145:1IAQ
141:1HE8
137:1GNR
133:1GNQ
129:1GNP
125:1CTQ
121:1CRR
117:1CRQ
113:1CRP
109:1CLU
105:1BKD
101:1AGP
97:1AA9
93:121P
74:RCSB
71:PDBe
40:HRAS
6200:BTK
5886:Ran
5854:Ras
5440:MAP
5375:MX2
5371:MX1
5291:RGK
5286:Rap
5276:Ran
5249:Arf
5232:Rab
5210:Ras
5168:Rnd
5146:Rho
5097:Rac
5073:TCL
4934:olf
4666:Ca+
4422:TSP
4367:VHL
4360:TSP
4346:CBL
4305:TSP
4275:p16
4270:WT1
4265:pRb
4260:p53
4253:TSP
4185:TSP
4142:TSP
4087:TSP
4058:TSP
4008:TSP
3986:APC
3979:TSP
3832:TSP
3803:TSP
3774:TSP
3739:HGF
2686:doi
2655:PMC
2647:doi
2606:doi
2573:doi
2536:doi
2488:doi
2447:PMC
2437:doi
2388:PMC
2380:doi
2333:doi
2284:doi
2245:doi
2233:213
2008:Ras
1992:GDP
1988:GTP
1918:of
1031:lip
894:End
793:End
696:OMA
672:MGI
64:PDB
6467::
6318::
5522:Gi
5518:Gs
5056::
4944:αi
4926:αs
4904::
4627::
4549:EC
4543::
2700:.
2692:.
2680:.
2663:.
2653:.
2643:92
2641:.
2637:.
2620:.
2612:.
2587:.
2579:.
2569:17
2567:.
2550:.
2542:.
2532:42
2530:.
2502:.
2494:.
2484:26
2482:.
2455:.
2445:.
2435:.
2425:11
2423:.
2419:.
2396:.
2386:.
2374:.
2370:.
2347:.
2339:.
2329:39
2327:.
2290:.
2280:35
2278:.
2274:.
2251:.
2243:.
2231:.
2212:.
2194:.
2165:^
2144:^
1938:.
1500:/
900:bp
887:bp
799:bp
786:bp
694:;
690::
686:;
682::
678:;
674::
670:;
666::
619:,
615:,
611:,
607:,
603:,
599:,
595:,
591:,
587:,
583:,
579:,
575:,
571:,
567:,
563:,
559:,
555:,
551:,
547:,
543:,
539:,
535:,
531:,
527:,
523:,
519:,
515:,
511:,
507:,
503:,
499:,
495:,
491:,
487:,
483:,
479:,
475:,
471:,
467:,
463:,
459:,
455:,
451:,
447:,
443:,
439:,
435:,
431:,
427:,
423:,
419:,
415:,
411:,
407:,
403:,
399:,
395:,
391:,
387:,
383:,
379:,
375:,
371:,
367:,
363:,
359:,
355:,
351:,
347:,
343:,
339:,
335:,
331:,
327:,
323:,
319:,
315:,
311:,
307:,
303:,
299:,
295:,
291:,
287:,
283:,
279:,
275:,
271:,
267:,
263:,
259:,
255:,
251:,
247:,
243:,
239:,
235:,
231:,
227:,
223:,
219:,
215:,
211:,
207:,
203:,
199:,
195:,
191:,
187:,
183:,
179:,
175:,
171:,
167:,
163:,
159:,
155:,
151:,
147:,
143:,
139:,
135:,
131:,
127:,
123:,
119:,
115:,
111:,
107:,
103:,
99:,
95:,
6309::
6290::
6171::
5991:2
5986:1
5974::
5737:γ
5735:G
5704:β
5702:G
5605:α
5603:G
5556::
5520:/
5506::
5425:e
5418:t
5411:v
5183:3
5178:2
5173:1
5161:C
5156:B
5151:A
5134:2
5129:1
5112:3
5107:2
5016:G
4996:G
4942:G
4932:G
4924:G
4625:4
4623:-
4547:(
4533:e
4526:t
4519:v
4295:/
4277:/
3870:/
3690:e
3683:t
3676:v
2759:e
2752:t
2745:v
2708:.
2688::
2671:.
2649::
2628:.
2608::
2595:.
2575::
2558:.
2538::
2510:.
2490::
2463:.
2439::
2431::
2404:.
2382::
2376:8
2355:.
2335::
2312:.
2298:.
2286::
2259:.
2247::
2239::
2216:.
2198:.
818:)
715:)
698::
34:.
20:)
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