22:
2682:
2703:
659:
645:
receptor antagonists may have a potential role in managing bladder conditions such as overactive bladder, they are not typically used in treating cystitis or painful bladder disease, and their mechanism of action in bladder diseases is still not fully understood. There is limited research that
538:
antagonists offer several advantages over antacids, including longer duration of action (6–10 hours vs 1–2 hours for antacids), greater efficacy, and ability to be used prophylactically before meals to reduce the chance of heartburn occurring. Proton pump inhibitors, however, are the preferred
622:
receptors in the bladder smooth muscle, leading to relaxation of the bladder muscle and promotion of urine storage. Histamine does not seem to have a direct role in the development of bladder diseases, but it can contribute to bladder inflammation and associated symptoms.
791:
receptor antagonists are less likely to alter CYP metabolism. Ranitidine is not as potent a CYP inhibitor as cimetidine, although it still shares several of the latter's interactions (such as with warfarin, theophylline, phenytoin, metoprolol, and midazolam).
582:
occurred in 0.1% to 0.5% of men treated for non-hypersecretory conditions with cimetidine for 1 month or longer and in about 2% of men treated for pathologic hypersecretory conditions; in even fewer men, cimetidine may also cause loss of libido, and
1548:"Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/Interstitial cystitis - significance in the responsiveness to antihistamine treatment and disease symptoms"
1026:
Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, d'Ambrosi A, Amoroso P, Pacini F, Salvadori G (1997). "Acute liver injury related to the use of niperotidine".
306:
had no effect on acid production. From these facts the SK&F scientists postulated the existence of two different types of histamine receptors. They designated the one acted upon by the traditional antihistamines as
391:), in an effort to match the success of Smith, Kline & French with cimetidine. Ranitidine was also the result of a rational drug design process utilising the by-then-fairly-refined model of the histamine H
869:
Eriksson S, Långström G, Rikner L, Carlsson R, Naesdal J (1995). "Omeprazole and H2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis".
318:
The SK&F team used a classical design process starting from the structure of histamine. Hundreds of modified compounds were synthesised in an effort to develop a model of the then-unknown H
3442:
618:
Histamine can cause bladder inflammation and contribute to the symptoms of such bladder diseases as cystitis (inflammation of the bladder) or painful bladder disease. Histamine binds to H
1172:
Meng R, Chen LR, Zhang ML, Cai WK, Yin SJ, Fan YX, Zhou T, Huang YH, He GH (2023). "Effectiveness and Safety of
Histamine H2 Receptor Antagonists: An Umbrella Review of Meta-Analyses".
353:
The potency of burimamide was still too low for oral administration. And efforts on further improvement of the structure, based on the structure modification in the stomach due to the
3878:
2634:
1714:
518:
antagonists reduce gastric acidity and volume and have shown to reduce the frequency of aspiration pneumonitis; however, this aspiration benefit has not been shown with IV H
1358:"The combination of loratadine with famotidine to relieve the symptoms of urinary frequency in female patients with bladder function disorders：First report of three cases"
446:. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: Histamine released by
396:
287:
receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by
2691:
3774:
3435:
559:
antagonists are generally well tolerated, with the exception of cimetidine, which more commonly elicits the following adverse drug reactions (ADRs) than other H
2740:
198:
3871:
1704:
955:
2485:
3804:
5397:
3428:
3194:
1682:
637:
receptor antagonists have been shown to reduce bladder contractions and improve bladder function in animal studies. Blocking the activation of H
5402:
3864:
3822:
3789:
2058:
1456:"Oral cimetidine gives effective symptom relief in painful bladder disease: A prospective, randomized, double-blind placebo-controlled trial"
1407:"Oral cimetidine gives effective symptom relief in painful bladder disease: A prospective, randomized, double-blind placebo-controlled trial"
2345:
2338:
2445:
4891:
3931:
2088:
3621:
3347:
3291:
1951:
411:-containing substituent, and in doing so developed ranitidine, which was found to have a much better tolerability profile (i.e. fewer
1503:
Dasgupta P, Sharma SD, Womack C, Blackford HN, Dennis P (2001). "Cimetidine in painful bladder syndrome: A histopathological study".
3000:
1106:
1075:
5423:
3779:
3184:
2733:
3456:
3366:
3280:
2241:
1697:
492:
100:
1250:"Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors"
3352:
1600:
Humphries TJ, Merritt GJ (August 1999). "Review article: drug interactions with agents used to treat acid-related diseases".
847:
3174:
2828:
2822:
1066:
781:
1940:
5392:
3341:
3113:
1722:
330:
receptor antagonist. From this lead, the receptor model was further refined, which eventually led to the development of
422:
receptor antagonists have since largely been superseded by the even more effective proton pump inhibitors (PPIs), with
3839:
3256:
3029:
2726:
2551:
4672:
3095:
2934:
2921:
2892:
2837:
2201:
1690:
479:
447:
377:
analogues were investigated until the discovery of cimetidine, which would become the first clinically successful H
354:
3391:
2908:
951:
757:
4702:
4173:
3285:
3231:
3216:
3188:
2969:
2964:
2955:
840:"ASP (PPI_H2RA) Study-H2RA Versus PPI for the Prevention of Recurrent UGIB in High-risk Users of Low-dose ASA"
3963:
3827:
3386:
3357:
3325:
3155:
2960:
2916:
2867:
2798:
2256:
1934:
1785:
765:
454:
receptors, which stimulate acid secretion; therefore, other substances that promote acid secretion (such as
4593:
3784:
3527:
3267:
3073:
2293:
2048:
335:
5308:
5285:
5102:
5084:
4853:
4756:
3898:
3663:
3551:
3398:
3242:
2975:
2862:
1978:
1914:
1759:
439:
412:
167:
104:
68:
418:
Ranitidine was introduced in 1981 and was the world's biggest-selling prescription drug by 1988. The H
3678:
3403:
3247:
3100:
3053:
2053:
2033:
1902:
1261:
511:
25:
641:
receptors in the bladder leads to decreased bladder contractions and improved urine storage. While H
4558:
4103:
3916:
3024:
2812:
2662:
2398:
2184:
1963:
1790:
163:
112:
60:
5030:
5025:
4965:
4925:
4834:
4814:
4533:
4453:
4433:
2702:
5060:
4995:
4940:
4824:
4568:
4508:
4488:
4478:
4393:
4363:
4168:
4098:
4088:
3890:
3887:
3683:
3596:
3512:
3251:
3220:
2951:
2847:
2696:
2561:
2420:
1874:
1668:
1625:
1528:
1485:
1436:
1387:
1197:
296:
5357:
5236:
5055:
5020:
4955:
4945:
4829:
4819:
4809:
4804:
4578:
4528:
4388:
4373:
4368:
4348:
3642:
650:
receptor antagonists can potentially alleviate symptoms of cystitis or painful bladder disease.
5216:
5065:
5050:
5010:
4975:
4839:
4583:
4543:
4523:
4513:
4423:
5303:
5186:
4799:
4654:
3420:
3320:
3225:
3048:
2841:
2657:
2440:
2430:
2333:
2163:
2119:
2103:
1907:
1897:
1840:
1830:
1660:
1617:
1579:
1520:
1477:
1428:
1379:
1338:
1287:
1189:
1153:
1071:
1044:
1008:
933:
879:
292:
189:– in the mid-to-late 1960s. It was first marketed in 1976 and sold under the trade name
5181:
5176:
302:
In 1964, it was known that histamine stimulated the secretion of stomach acid, and also that
4780:
4647:
4263:
4123:
4043:
3753:
3310:
3104:
3019:
2773:
2667:
2490:
2415:
2403:
2328:
2194:
2073:
1862:
1652:
1643:
Kirch W, Hoensch H, Janisch HD (1984). "Interactions and non-interactions with ranitidine".
1609:
1569:
1559:
1512:
1467:
1418:
1369:
1328:
1318:
1277:
1269:
1228:
1181:
1143:
1135:
1124:"Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis"
1036:
998:
990:
923:
915:
674:
662:
210:
194:
709:. By reducing the metabolism of drugs through these enzymes, cimetidine may increase their
4183:
4143:
4118:
4003:
3566:
3238:
3150:
2988:
2983:
2853:
2817:
2807:
2790:
2707:
2652:
2521:
2516:
2355:
2288:
2283:
2169:
2115:
1956:
1847:
1800:
1110:
796:
has negligible effect on the CYP system, and appears to have no significant interactions.
761:
682:
678:
601:
receptor antagonist is associated with pneumonia, peritonitis, necrotizing enterocolitis,
388:
366:
186:
182:
159:
21:
1103:
1265:
5231:
4760:
4650:
4473:
4413:
4328:
4163:
4108:
4078:
4038:
4028:
4023:
3833:
2930:
2785:
2768:
2686:
2586:
2581:
2435:
2425:
2375:
2360:
2350:
2251:
2246:
2236:
2174:
2146:
2098:
2093:
1825:
1780:
1776:
1574:
1547:
1333:
1306:
1282:
1249:
1148:
1123:
1003:
978:
928:
903:
362:
288:
234:(Zantac) (withdrawn in USA, suspended in EU and Australia for carcinogenic metabolites)
1040:
111:
was found to be more effective at both healing and alleviating symptoms of ulcers and
5417:
4746:
4742:
4706:
4666:
4609:
4605:
4468:
4418:
4308:
4293:
4218:
4213:
4018:
3688:
3606:
3522:
3469:
3166:
3065:
3057:
3040:
2979:
2618:
2591:
2450:
2268:
2179:
2159:
2155:
2018:
1946:
1835:
1750:
1656:
1613:
1516:
1472:
1455:
1423:
1406:
1391:
1307:"Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis"
1201:
904:"International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors"
814:
805:
773:
769:
713:
590:
A 31-study review found that overall risk of pneumonia is about 1 in 4 higher among H
459:
311:, and the one acted upon by histamine to stimulate the secretion of stomach acid as H
303:
209:, which was thought to have a better adverse effect profile (later disproven), fewer
139:
135:
76:
1672:
1532:
1489:
1440:
5362:
5266:
5206:
5127:
5000:
4784:
4776:
4768:
4764:
4750:
4714:
4710:
4696:
4625:
4597:
4463:
4448:
4333:
4323:
4318:
4313:
4288:
4283:
4253:
4233:
4223:
4188:
4138:
4068:
3988:
3733:
3673:
3591:
3581:
3571:
3561:
3460:
3452:
3145:
3011:
2994:
2749:
2576:
2495:
2231:
2189:
2023:
2013:
1929:
1924:
1629:
725:
710:
579:
504:
486:
266:
96:
84:
2134:
839:
1217:"Physiological Role of Histamine H2 Receptor on Bladder Sensory Function in Rats"
669:. Unlike cimetidine, famotidine has no significant interactions with other drugs.
361:. Metiamide was an effective agent; however, it was associated with unacceptable
5347:
5318:
5251:
5246:
5241:
5226:
5191:
5132:
5107:
5070:
4980:
4901:
4896:
4788:
4738:
4718:
4692:
4684:
4637:
4633:
4617:
4573:
4538:
4518:
4498:
4493:
4378:
4343:
4303:
4268:
4258:
4243:
4208:
4198:
4178:
4158:
4153:
4148:
4113:
4063:
4058:
4048:
3993:
3968:
3936:
3921:
3856:
3738:
3713:
3708:
3703:
3668:
3611:
3601:
3536:
3497:
3302:
3275:
3208:
2901:
2781:
2460:
2370:
2110:
2063:
2008:
1891:
1857:
994:
741:
567:
540:
260:
1273:
1233:
1216:
5367:
5256:
5221:
5201:
5196:
5140:
5045:
5040:
5035:
5015:
5005:
4985:
4970:
4960:
4950:
4935:
4930:
4730:
4658:
4629:
4621:
4548:
4483:
4443:
4438:
4403:
4398:
4358:
4353:
4278:
4203:
4128:
4093:
4083:
4053:
4033:
4013:
3973:
3758:
3728:
3723:
3718:
3647:
3637:
3632:
3586:
3576:
3507:
3502:
3492:
3487:
3482:
3128:
2943:
2638:
2609:
2567:
2536:
2531:
2470:
2465:
2455:
2393:
2379:
2319:
2274:
2222:
2142:
2138:
2079:
2039:
1994:
1990:
1880:
1816:
1766:
1731:
1727:
1564:
793:
749:
685:(CYP) pathway. To be specific, cimetidine is an inhibitor of the P450 enzymes
666:
423:
384:
331:
272:
254:
249:
243:
237:
231:
225:
206:
202:
178:
124:
120:
108:
29:
5352:
5313:
5261:
5211:
5112:
4990:
4886:
4871:
4734:
4722:
4688:
4676:
4662:
4613:
4601:
4563:
4553:
4503:
4458:
4408:
4383:
4298:
4273:
4248:
4238:
4228:
4193:
4133:
4073:
4008:
3998:
3978:
3926:
3748:
3743:
3698:
3693:
3541:
3137:
3087:
2546:
2526:
2500:
2475:
2410:
2388:
2216:
2129:
2003:
753:
745:
737:
733:
729:
677:, cimetidine in particular interferes with some of the body's mechanisms of
584:
498:
438:
antagonists are competitive antagonists of histamine at the parietal cell's
400:
374:
358:
92:
64:
1621:
1583:
1524:
1481:
1432:
1383:
1342:
1323:
1291:
1193:
1157:
1012:
937:
138:. In general usage, however, the term "antihistamine" typically refers to
1664:
1088:
Miller RD, Eriksson L, Fleisher LA, Wiener-Kronish JP (25 November 2014).
1048:
919:
883:
5372:
5331:
5271:
5166:
5161:
5145:
4881:
4876:
4772:
4680:
4641:
4428:
3983:
3178:
2647:
2511:
2507:
2480:
1919:
1852:
1771:
979:"Mechanisms of drug toxicity and relevance to pharmaceutical development"
721:
630:
receptors in the bladder play a role in regulating bladder contraction.
575:
571:
527:
408:
370:
1139:
5171:
5122:
4909:
4726:
3944:
2802:
2623:
2541:
2206:
1973:
1795:
1745:
1374:
1357:
777:
694:
658:
455:
190:
147:
80:
1185:
5326:
5117:
3315:
2884:
2764:
2718:
2305:
1968:
706:
702:
698:
690:
686:
605:
infection, liver cancer, gastric cancer, and hip fracture diseases.
478:
antagonists are used by clinicians in the treatment of acid-related
415:), longer-lasting action, and ten times the activity of cimetidine.
201:(QSAR) led to the development of other agents – starting with
1546:
Shan H, Zhang EW, Zhang P, Zhang XD, Zhang N, Du P, Yang Y (2019).
2605:
2315:
1810:
717:
657:
597:
According to a 2022 umbrella review of meta-analyses, the use of H
404:
20:
2309:
3860:
3424:
2722:
1686:
450:(ECL) in the stomach is blocked from binding on parietal cell H
1356:
Zhou H, Zhou Y, Ping Y, Tian S, Li G, Cui Y, Zheng B (2019).
526:
People who suffer from infrequent heartburn may take either
387:(common brand name Zantac) was developed by Glaxo (also now
543:
since they have been shown to promote healing better than H
1122:
Eom CS, Jeon CY, Lim JW, Cho EG, Park SM, Lee KS (2011).
399:(QSAR). Glaxo refined the model further by replacing the
299:
antagonist that would suppress stomach acid secretion.
134:
antagonists, which all end in "-tidine", are a type of
1715:
890:
European
Journal of Gastroenterology & Hepatology
587:, all of which are reversible upon discontinuation.
462:) have a reduced effect on parietal cells when the H
5340:
5296:
5284:
5154:
5095:
5083:
4918:
4864:
4852:
3953:
3909:
3897:
3767:
3656:
3620:
3550:
3521:
3468:
3379:
3334:
3301:
3266:
3207:
3165:
3136:
3127:
3086:
3039:
3010:
2942:
2929:
2915:
2900:
2883:
2876:
2756:
2632:
2604:
2560:
2369:
2304:
2267:
2215:
2128:
2072:
2032:
1989:
1873:
1809:
1721:
902:Panula P, Chazot PL, Cowart M, et al. (2015).
369:. It was proposed that the toxicity arose from the
342:receptor. Burimamide is 100 times more potent than
1090:Miller's Anesthesia Airway management in the Adult
426:becoming the biggest-selling drug for many years.
1454:Thilagarajah R, Witherow RO, Walker MM (2001).
1405:Thilagarajah R, Witherow RO, Walker MM (2001).
1248:Stromberga Z, Chess-Williams R, Moro C (2019).
1070:2005. Adelaide: Australian Medicines Handbook.
346:-guanylhistamine, proving its efficacy on the H
3872:
3775:Bismuth subcitrate/metronidazole/tetracycline
3436:
2734:
1698:
1362:Journal of Clinical Pharmacy and Therapeutics
1092:(8th ed.). Elsevier. pp. 1647–1681.
397:quantitative structure-activity relationships
199:quantitative structure-activity relationships
8:
1713:Major chemical drug groups – based upon the
1595:
1593:
91:antagonists can be used in the treatment of
1305:Rudick CN, Schaeffer AJ, Klumpp DJ (2009).
720:levels. Many drugs are affected, including
357:of the compound, led to the development of
283:Cimetidine was the prototypical histamine H
5293:
5092:
4861:
3906:
3879:
3865:
3857:
3443:
3429:
3421:
3133:
2939:
2926:
2880:
2741:
2727:
2719:
1705:
1691:
1683:
1602:Alimentary Pharmacology & Therapeutics
1573:
1563:
1471:
1422:
1373:
1332:
1322:
1281:
1232:
1147:
1002:
927:
534:receptor antagonists for treatment. The H
185:at Smith, Kline & French – now
1060:
1058:
830:
578:, constipation, and rash. In addition,
2692:Pharmacological classification systems
2059:Selective estrogen receptor modulators
776:, and some recreational drugs such as
3790:Vonoprazan/amoxicillin/clarithromycin
2339:Non-steroidal anti-inflammatory drugs
507:(a specific indication of ranitidine)
322:receptor. The first breakthrough was
7:
1174:The Journal of Clinical Pharmacology
983:Drug Metabolism and Pharmacokinetics
850:from the original on 1 December 2018
257:(Stogar, Lafaxid, Ildong Lafutidine)
1952:Angiotensin II receptor antagonists
952:"Sir James W. Black - Biographical"
574:, tiredness, dizziness, confusion,
269:(withdrawn as causing liver damage)
83:. This decreases the production of
4144:Etybenzatropine (ethylbenztropine)
3348:Angiotensin II receptor antagonist
3292:Endocannabinoid reuptake inhibitor
958:from the original on 23 April 2015
681:and elimination through the liver
14:
3239:Acetylcholine receptor antagonist
3001:Norepinephrine reuptake inhibitor
838:Francis KL Chan (21 April 2017).
3780:Omeprazole/amoxicillin/rifabutin
2701:
2681:
2680:
1657:10.2165/00003088-198409060-00002
1614:10.1046/j.1365-2036.1999.00021.x
1517:10.1046/j.1464-410x.2001.02258.x
1473:10.1046/j.1464-410x.2001.02031.x
1424:10.1046/j.1464-410x.2001.02031.x
888:. A correction was published in
221:This list may not be exhaustive.
5398:Monoamine metabolism modulators
3367:Vasopressin receptor antagonist
3281:Cannabinoid receptor antagonist
2089:Hypothalamic–pituitary hormones
493:Gastroesophageal reflux disease
101:gastroesophageal reflux disease
3353:Endothelin receptor antagonist
3217:Acetylcholine receptor agonist
2976:Adrenergic receptor antagonist
103:. They have been surpassed by
1:
5403:Monoamine reuptake inhibitors
5393:Receptor/signaling modulators
3185:Glutamate receptor antagonist
3101:Serotonin receptor antagonist
3054:Histamine receptor antagonist
2829:Negative allosteric modulator
2823:Positive allosteric modulator
1841:Thrombolytics / fibrinolytics
1067:Australian Medicines Handbook
1041:10.1016/s0168-8278(97)80365-0
787:The more recently developed H
782:methylenedioxymethamphetamine
326:-guanylhistamine, a partial H
3342:Adenosine reuptake inhibitor
3276:Cannabinoid receptor agonist
3195:Glutamate reuptake inhibitor
3114:Serotonin reuptake inhibitor
3025:Dopamine receptor antagonist
2552:Wakefulness-promoting agents
263:(discontinued as carcinogen)
5026:Quisultazine (quisultidine)
4673:Tetracyclic antidepressants
3030:Dopamine reuptake inhibitor
2952:Adrenergic receptor agonist
1215:Aizawa N, Fujita T (2023).
1162:(adjusted odds ratio 1.22)
995:10.2133/dmpk.dmpk-10-rv-062
872:Eur J Gastroenterol Hepatol
480:gastrointestinal conditions
448:enterochromaffin-like cells
403:-ring of cimetidine with a
47:, sometimes referred to as
5440:
3989:Benzatropine (benztropine)
3321:Opioid receptor antagonist
3175:Glutamate receptor agonist
3096:Serotonin receptor agonist
3049:Histamine receptor agonist
2202:Intravenous immunoglobulin
1274:10.1038/s41598-019-40384-1
1234:10.1016/j.cont.2023.100808
355:acid dissociation constant
304:traditional antihistamines
295:, and others to develop a
220:
5385:
4703:Tricyclic antidepressants
4559:Sequifenadine (bicarphen)
3817:
3798:
3020:Dopamine receptor agonist
2676:
1645:Clinical Pharmacokinetics
1565:10.1186/s12894-019-0548-3
1104:"Cimetidine Side Effects"
758:tricyclic antidepressants
193:, which became the first
63:that block the action of
4341:Second/third-generation:
4174:Hydroxyethylpromethazine
3286:Endocannabinoid enhancer
3232:Cholinesterase inhibitor
3151:GABA receptor antagonist
2257:Topoisomerase inhibitors
1941:renin–angiotensin system
1935:Calcium channel blockers
766:calcium channel blockers
566:Infrequent ADRs include
158:antagonists function as
5424:H2 receptor antagonists
4981:Lavoltidine (loxtidine)
4594:Atypical antipsychotics
4539:Quifenadine (phencarol)
4204:Mepyramine (pyrilamine)
3964:4-Methyldiphenhydramine
3498:Lavoltidine (loxtidine)
3326:Enkephalinase inhibitor
3316:Opioid receptor agonist
3156:GABA reuptake inhibitor
2861:♦ Miscellaneous:
908:Pharmacological Reviews
466:receptors are blocked.
279:History and development
4757:Typical antipsychotics
3785:Vonoprazan/amoxicillin
3622:Potassium-competitive
3552:Proton-pump inhibitors
2909:Ion channel modulators
2049:Hormonal contraception
1979:Bile acid sequestrants
1760:Proton-pump inhibitors
1723:gastrointestinal tract
1324:10.1186/1471-2490-9-16
1064:Rossi S (Ed.) (2005).
977:Guengerich FP (2011).
670:
539:treatment for erosive
514:during surgery. Oral H
512:aspiration pneumonitis
413:adverse drug reactions
336:competitive antagonist
105:proton pump inhibitors
37:
4723:dosulepin (dothiepin)
3808:eradication protocols
3664:Aceglutamide aluminum
3146:GABA receptor agonist
1029:Journal of Hepatology
920:10.1124/pr.114.010249
661:
603:Clostridium difficile
570:. Rare ADRs include:
168:constitutive activity
24:
3679:Arbaclofen placarbil
2658:Radiopharmaceuticals
2446:Antiparkinson agents
819:-receptor antagonist
810:-receptor antagonist
213:and be more potent.
170:of these receptors.
164:receptor antagonists
32:, the prototypical H
26:Ball-and-stick model
16:Class of medications
4104:Dexchlorpheniramine
3917:2-Pyridylethylamine
3806:Helicobacter pylori
3362:receptor antagonist
2441:Antimigraine agents
2431:Antidementia agents
2334:Anti-inflammatories
2024:Medicated dressings
1964:Antihyperlipidemics
1791:Diabetes medication
1266:2019NatSR...9.3899S
1140:10.1503/cmaj.092129
373:group, and similar
181:, was developed by
177:antagonist, called
154:antagonists, some H
113:reflux oesophagitis
36:receptor antagonist
4169:Homochlorcyclizine
4099:Dexbrompheniramine
3888:Histamine receptor
3844:Never to phase III
3684:Bismuth subcitrate
2750:Pharmacomodulation
2294:Immunosuppressants
2164:Antimycobacterials
2120:Antithyroid agents
2104:Mineralocorticoids
1908:Cardiac stimulants
1898:Cardiac glycosides
1890:cardiac therapy /
1786:Anti-obesity drugs
1608:(Suppl 3): 18–26.
1375:10.1111/jcpt.12845
1254:Scientific Reports
1109:2017-11-07 at the
954:. Nobelprize.org.
844:ClinicalTrials.gov
764:, dihydropyridine
671:
594:antagonist users.
297:histamine receptor
173:The prototypical H
148:allergic reactions
38:
5411:
5410:
5381:
5380:
5309:α-Methylhistamine
5304:4-Methylhistamine
5280:
5279:
5103:α-Methylhistamine
5079:
5078:
4848:
4847:
4797:Unknown/unsorted:
4655:hydroxynefazodone
3961:First-generation:
3854:
3853:
3418:
3417:
3414:
3413:
3375:
3374:
3203:
3202:
3123:
3122:
2893:Enzyme inhibition
2716:
2715:
2619:Ophthalmologicals
2329:Anabolic steroids
2232:Anticancer agents
2195:Ectoparasiticides
1915:Antihypertensives
1863:Antifibrinolytics
1505:BJU International
1460:BJU International
1411:BJU International
1186:10.1002/jcph.2147
654:Drug interactions
293:C. Robin Ganellin
211:drug interactions
59:, are a class of
5431:
5321:
5294:
5135:
5093:
4904:
4862:
4781:prochlorperazine
4648:Phenylpiperazine
4264:Phenyltoloxamine
4124:Diphenylpyraline
4044:Chlorphenoxamine
3939:
3907:
3881:
3874:
3867:
3858:
3754:Zinc L-carnosine
3445:
3438:
3431:
3422:
3392:Enzyme cofactors
3311:Opioid modulator
3268:Cannabinoidergic
3134:
2940:
2927:
2881:
2743:
2736:
2729:
2720:
2705:
2684:
2683:
2668:Senotherapeutics
2522:Neuroprotectives
2517:Mood stabilizers
2416:Anti-ADHD agents
2356:Muscle relaxants
2289:Immunostimulants
2284:Immunomodulators
2116:Thyroid hormones
2054:Fertility agents
1957:Renin inhibitors
1848:Antihemorrhagics
1815:forming organs (
1801:Dietary minerals
1707:
1700:
1693:
1684:
1677:
1676:
1640:
1634:
1633:
1597:
1588:
1587:
1577:
1567:
1543:
1537:
1536:
1500:
1494:
1493:
1475:
1451:
1445:
1444:
1426:
1402:
1396:
1395:
1377:
1353:
1347:
1346:
1336:
1326:
1302:
1296:
1295:
1285:
1245:
1239:
1238:
1236:
1212:
1206:
1205:
1169:
1163:
1161:
1151:
1119:
1113:
1100:
1094:
1093:
1085:
1079:
1062:
1053:
1052:
1023:
1017:
1016:
1006:
974:
968:
967:
965:
963:
948:
942:
941:
931:
899:
893:
887:
866:
860:
859:
857:
855:
835:
675:pharmacokinetics
663:Skeletal formula
614:Bladder diseases
205:, first sold as
195:blockbuster drug
160:inverse agonists
146:, which relieve
107:(PPIs). The PPI
51:and also called
5439:
5438:
5434:
5433:
5432:
5430:
5429:
5428:
5414:
5413:
5412:
5407:
5377:
5336:
5319:
5289:
5276:
5150:
5133:
5088:
5075:
4914:
4902:
4857:
4844:
4651:antidepressants
4184:Isopromethazine
4119:Diphenhydramine
4004:Brompheniramine
3949:
3937:
3902:
3893:
3885:
3855:
3850:
3849:
3834:Clinical trials
3813:
3794:
3763:
3652:
3623:
3616:
3567:Dexlansoprazole
3554:
3546:
3526:
3517:
3473:
3464:
3449:
3419:
3410:
3371:
3361:
3330:
3297:
3262:
3199:
3161:
3119:
3108:
3082:
3077:
3069:
3061:
3035:
3006:
2920:
2911:
2896:
2872:
2818:Inverse agonist
2808:Partial agonist
2752:
2747:
2717:
2712:
2708:Medicine portal
2672:
2628:
2600:
2595:
2587:Cough medicines
2582:Bronchodilators
2563:
2556:
2436:Antidepressants
2426:Anticonvulsants
2374:
2365:
2361:Bisphosphonates
2351:Corticosteroids
2313:
2300:
2272:
2263:
2247:Spindle poisons
2237:Antimetabolites
2220:
2211:
2133:
2124:
2099:Glucocorticoids
2094:Corticosteroids
2075:
2068:
2035:
2028:
1985:
1903:Antiarrhythmics
1876:
1869:
1826:Antithrombotics
1814:
1805:
1781:Antipropulsives
1777:Antidiarrhoeals
1754:
1725:
1717:
1711:
1681:
1680:
1642:
1641:
1637:
1599:
1598:
1591:
1545:
1544:
1540:
1502:
1501:
1497:
1453:
1452:
1448:
1404:
1403:
1399:
1355:
1354:
1350:
1304:
1303:
1299:
1247:
1246:
1242:
1214:
1213:
1209:
1171:
1170:
1166:
1121:
1120:
1116:
1111:Wayback Machine
1101:
1097:
1087:
1086:
1082:
1063:
1056:
1025:
1024:
1020:
976:
975:
971:
961:
959:
950:
949:
945:
901:
900:
896:
868:
867:
863:
853:
851:
837:
836:
832:
827:
818:
809:
802:
790:
762:benzodiazepines
683:cytochrome P450
679:drug metabolism
673:With regard to
656:
649:
644:
640:
636:
629:
621:
616:
611:
600:
593:
562:
558:
553:
551:Adverse effects
546:
537:
533:
521:
517:
477:
472:
465:
453:
443:
437:
432:
421:
394:
389:GlaxoSmithKline
380:
367:agranulocytosis
349:
341:
329:
321:
314:
310:
286:
281:
222:
219:
187:GlaxoSmithKline
183:Sir James Black
176:
157:
153:
143:
133:
118:
90:
72:
56:
44:
35:
17:
12:
11:
5:
5437:
5435:
5427:
5426:
5416:
5415:
5409:
5408:
5406:
5405:
5400:
5395:
5390:
5386:
5383:
5382:
5379:
5378:
5376:
5375:
5370:
5365:
5360:
5355:
5350:
5344:
5342:
5338:
5337:
5335:
5334:
5329:
5324:
5316:
5311:
5306:
5300:
5298:
5291:
5287:
5282:
5281:
5278:
5277:
5275:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5232:Iodophenpropit
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5158:
5156:
5152:
5151:
5149:
5148:
5143:
5138:
5130:
5125:
5120:
5115:
5110:
5105:
5099:
5097:
5090:
5086:
5081:
5080:
5077:
5076:
5074:
5073:
5068:
5063:
5058:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4922:
4920:
4916:
4915:
4913:
4912:
4907:
4899:
4894:
4889:
4884:
4879:
4874:
4868:
4866:
4859:
4855:
4850:
4849:
4846:
4845:
4843:
4842:
4837:
4832:
4827:
4822:
4817:
4812:
4807:
4802:
4793:
4792:
4761:chlorpromazine
4754:
4700:
4670:
4645:
4587:
4586:
4581:
4576:
4571:
4566:
4561:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4474:Levocetirizine
4471:
4466:
4461:
4456:
4451:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4414:Clobenztropine
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4337:
4336:
4331:
4329:Tripelennamine
4326:
4321:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4164:Histapyrrodine
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4109:Dimenhydrinate
4106:
4101:
4096:
4091:
4086:
4081:
4079:Cyproheptadine
4076:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4039:Chlorphenamine
4036:
4031:
4029:Chloropyramine
4026:
4024:Chlorcyclizine
4021:
4016:
4011:
4006:
4001:
3996:
3991:
3986:
3981:
3976:
3971:
3966:
3957:
3955:
3951:
3950:
3948:
3947:
3942:
3934:
3929:
3924:
3919:
3913:
3911:
3904:
3900:
3895:
3894:
3886:
3884:
3883:
3876:
3869:
3861:
3852:
3851:
3848:
3847:
3846:
3845:
3842:
3831:
3825:
3819:
3818:
3815:
3814:
3812:
3811:
3799:
3796:
3795:
3793:
3792:
3787:
3782:
3777:
3771:
3769:
3765:
3764:
3762:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3660:
3658:
3654:
3653:
3651:
3650:
3645:
3640:
3635:
3629:
3627:
3618:
3617:
3615:
3614:
3609:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3558:
3556:
3548:
3547:
3545:
3544:
3539:
3533:
3531:
3523:Prostaglandins
3519:
3518:
3516:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3479:
3477:
3471:
3466:
3465:
3450:
3448:
3447:
3440:
3433:
3425:
3416:
3415:
3412:
3411:
3409:
3408:
3396:
3383:
3381:
3377:
3376:
3373:
3372:
3370:
3369:
3364:
3359:
3355:
3350:
3345:
3338:
3336:
3332:
3331:
3329:
3328:
3323:
3318:
3313:
3307:
3305:
3299:
3298:
3296:
3295:
3289:
3283:
3278:
3272:
3270:
3264:
3263:
3261:
3260:
3254:
3245:
3236:
3235:
3234:
3223:
3213:
3211:
3205:
3204:
3201:
3200:
3198:
3197:
3192:
3182:
3171:
3169:
3163:
3162:
3160:
3159:
3153:
3148:
3142:
3140:
3131:
3125:
3124:
3121:
3120:
3118:
3117:
3111:
3106:
3098:
3092:
3090:
3084:
3083:
3081:
3080:
3075:
3071:
3067:
3063:
3059:
3051:
3045:
3043:
3037:
3036:
3034:
3033:
3027:
3022:
3016:
3014:
3008:
3007:
3005:
3004:
2998:
2992:
2986:
2973:
2967:
2958:
2948:
2946:
2937:
2924:
2913:
2912:
2906:
2904:
2898:
2897:
2889:
2887:
2878:
2874:
2873:
2871:
2870:
2865:
2858:
2857:
2851:
2845:
2833:
2832:
2826:
2820:
2815:
2810:
2805:
2794:
2793:
2788:
2777:
2776:
2771:
2760:
2758:
2754:
2753:
2748:
2746:
2745:
2738:
2731:
2723:
2714:
2713:
2711:
2710:
2699:
2694:
2689:
2677:
2674:
2673:
2671:
2670:
2665:
2660:
2655:
2653:Contrast media
2650:
2644:
2642:
2630:
2629:
2627:
2626:
2621:
2615:
2613:
2606:sensory organs
2602:
2601:
2599:
2598:
2593:
2589:
2584:
2579:
2573:
2571:
2558:
2557:
2555:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2519:
2514:
2505:
2504:
2503:
2498:
2493:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
2451:Antipsychotics
2448:
2443:
2438:
2433:
2428:
2423:
2421:Antiaddictives
2418:
2413:
2408:
2407:
2406:
2401:
2391:
2385:
2383:
2376:nervous system
2367:
2366:
2364:
2363:
2358:
2353:
2348:
2346:Antirheumatics
2343:
2342:
2341:
2331:
2325:
2323:
2302:
2301:
2299:
2298:
2297:
2296:
2291:
2280:
2278:
2265:
2264:
2262:
2261:
2260:
2259:
2254:
2252:Antineoplastic
2249:
2244:
2239:
2228:
2226:
2213:
2212:
2210:
2209:
2204:
2199:
2198:
2197:
2192:
2187:
2185:Antiprotozoals
2180:Antiparasitics
2177:
2172:
2167:
2160:Antibacterials
2156:Antimicrobials
2152:
2150:
2126:
2125:
2123:
2122:
2113:
2108:
2107:
2106:
2101:
2091:
2085:
2083:
2070:
2069:
2067:
2066:
2061:
2056:
2051:
2045:
2043:
2030:
2029:
2027:
2026:
2021:
2019:Antipsoriatics
2016:
2011:
2006:
2000:
1998:
1987:
1986:
1984:
1983:
1982:
1981:
1976:
1971:
1961:
1960:
1959:
1954:
1949:
1947:ACE inhibitors
1937:
1932:
1927:
1922:
1917:
1912:
1911:
1910:
1905:
1900:
1886:
1884:
1875:cardiovascular
1871:
1870:
1868:
1867:
1866:
1865:
1860:
1855:
1845:
1844:
1843:
1838:
1836:Anticoagulants
1833:
1822:
1820:
1807:
1806:
1804:
1803:
1798:
1793:
1788:
1783:
1774:
1769:
1764:
1763:
1762:
1757:
1752:
1748:
1737:
1735:
1719:
1718:
1712:
1710:
1709:
1702:
1695:
1687:
1679:
1678:
1651:(6): 493–510.
1635:
1589:
1538:
1511:(3): 183–186.
1495:
1466:(3): 207–212.
1446:
1417:(3): 207–212.
1397:
1368:(5): 796–799.
1348:
1297:
1240:
1207:
1164:
1114:
1095:
1080:
1054:
1035:(3): 583–586.
1018:
969:
943:
894:
861:
829:
828:
826:
823:
822:
821:
816:
812:
807:
801:
798:
788:
714:concentrations
655:
652:
647:
642:
638:
634:
627:
619:
615:
612:
610:
607:
598:
591:
563:antagonists:
560:
556:
552:
549:
544:
535:
531:
524:
523:
519:
515:
510:Prevention of
508:
503:Prevention of
501:
496:
490:
475:
471:
468:
463:
451:
441:
435:
431:
428:
419:
392:
378:
363:nephrotoxicity
347:
339:
327:
319:
312:
308:
289:James W. Black
284:
280:
277:
276:
275:
270:
264:
258:
252:
247:
241:
235:
229:
218:
215:
174:
155:
151:
141:
131:
116:
88:
77:parietal cells
70:
54:
42:
33:
15:
13:
10:
9:
6:
4:
3:
2:
5436:
5425:
5422:
5421:
5419:
5404:
5401:
5399:
5396:
5394:
5391:
5388:
5387:
5384:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5354:
5351:
5349:
5346:
5345:
5343:
5339:
5333:
5330:
5328:
5325:
5323:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5301:
5299:
5295:
5292:
5290:
5283:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5159:
5157:
5153:
5147:
5144:
5142:
5139:
5137:
5131:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5104:
5101:
5100:
5098:
5094:
5091:
5089:
5082:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4923:
4921:
4917:
4911:
4908:
4906:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4869:
4867:
4863:
4860:
4858:
4851:
4841:
4838:
4836:
4833:
4831:
4828:
4826:
4823:
4821:
4818:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4795:
4794:
4790:
4786:
4782:
4778:
4774:
4770:
4766:
4762:
4758:
4755:
4752:
4748:
4747:protriptyline
4744:
4743:nortriptyline
4740:
4736:
4732:
4728:
4724:
4720:
4716:
4712:
4708:
4707:amitriptyline
4704:
4701:
4698:
4694:
4690:
4686:
4682:
4678:
4674:
4671:
4668:
4667:triazoledione
4664:
4660:
4656:
4652:
4649:
4646:
4643:
4639:
4635:
4631:
4627:
4623:
4619:
4615:
4611:
4610:brilaroxazine
4607:
4606:brexpiprazole
4603:
4599:
4595:
4592:
4589:
4588:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4470:
4469:Levocabastine
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4419:Desloratadine
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4339:
4338:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4309:Thenyldiamine
4307:
4305:
4302:
4300:
4297:
4295:
4294:Pyrrobutamine
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4219:Methapyrilene
4217:
4215:
4214:Methafurylene
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4019:Carbinoxamine
4017:
4015:
4012:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3959:
3958:
3956:
3952:
3946:
3943:
3941:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3914:
3912:
3908:
3905:
3903:
3896:
3892:
3889:
3882:
3877:
3875:
3870:
3868:
3863:
3862:
3859:
3843:
3841:
3838:
3837:
3835:
3832:
3829:
3826:
3824:
3821:
3820:
3816:
3810:
3809:
3807:
3801:
3800:
3797:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3772:
3770:
3766:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3689:Carbenoxolone
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3661:
3659:
3655:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3630:
3628:
3625:
3624:acid blockers
3619:
3613:
3610:
3608:
3607:Tenatoprazole
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3559:
3557:
3553:
3549:
3543:
3540:
3538:
3535:
3534:
3532:
3529:
3524:
3520:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3480:
3478:
3475:
3467:
3462:
3458:
3454:
3446:
3441:
3439:
3434:
3432:
3427:
3426:
3423:
3406:
3405:
3400:
3397:
3394:
3393:
3388:
3385:
3384:
3382:
3380:Miscellaneous
3378:
3368:
3365:
3363:
3356:
3354:
3351:
3349:
3346:
3343:
3340:
3339:
3337:
3333:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3308:
3306:
3304:
3300:
3293:
3290:
3287:
3284:
3282:
3279:
3277:
3274:
3273:
3271:
3269:
3265:
3258:
3255:
3253:
3249:
3246:
3244:
3240:
3237:
3233:
3230:
3229:
3227:
3224:
3222:
3218:
3215:
3214:
3212:
3210:
3206:
3196:
3193:
3190:
3186:
3183:
3180:
3176:
3173:
3172:
3170:
3168:
3167:Glutamatergic
3164:
3157:
3154:
3152:
3149:
3147:
3144:
3143:
3141:
3139:
3135:
3132:
3130:
3126:
3115:
3112:
3109:
3102:
3099:
3097:
3094:
3093:
3091:
3089:
3085:
3078:
3072:
3070:
3064:
3062:
3055:
3052:
3050:
3047:
3046:
3044:
3042:
3041:Histaminergic
3038:
3031:
3028:
3026:
3023:
3021:
3018:
3017:
3015:
3013:
3009:
3002:
2999:
2996:
2993:
2990:
2987:
2985:
2981:
2977:
2974:
2971:
2968:
2966:
2962:
2959:
2957:
2953:
2950:
2949:
2947:
2945:
2941:
2938:
2936:
2932:
2928:
2925:
2923:
2918:
2914:
2910:
2905:
2903:
2899:
2895:
2894:
2888:
2886:
2882:
2879:
2875:
2869:
2866:
2864:
2860:
2859:
2855:
2852:
2849:
2846:
2843:
2839:
2835:
2834:
2830:
2827:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2800:
2796:
2795:
2792:
2789:
2787:
2783:
2779:
2778:
2775:
2772:
2770:
2766:
2762:
2761:
2759:
2755:
2751:
2744:
2739:
2737:
2732:
2730:
2725:
2724:
2721:
2709:
2704:
2700:
2698:
2695:
2693:
2690:
2688:
2679:
2678:
2675:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2645:
2643:
2640:
2636:
2631:
2625:
2622:
2620:
2617:
2616:
2614:
2611:
2607:
2603:
2597:
2590:
2588:
2585:
2583:
2580:
2578:
2577:Decongestants
2575:
2574:
2572:
2569:
2565:
2559:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2509:
2506:
2502:
2499:
2497:
2496:Dissociatives
2494:
2492:
2489:
2488:
2487:
2486:Hallucinogens
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2405:
2402:
2400:
2397:
2396:
2395:
2392:
2390:
2387:
2386:
2384:
2381:
2377:
2372:
2368:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2340:
2337:
2336:
2335:
2332:
2330:
2327:
2326:
2324:
2321:
2317:
2311:
2307:
2303:
2295:
2292:
2290:
2287:
2286:
2285:
2282:
2281:
2279:
2276:
2270:
2266:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2234:
2233:
2230:
2229:
2227:
2224:
2218:
2214:
2208:
2205:
2203:
2200:
2196:
2193:
2191:
2190:Anthelmintics
2188:
2186:
2183:
2182:
2181:
2178:
2176:
2173:
2171:
2168:
2165:
2161:
2157:
2154:
2153:
2151:
2148:
2144:
2140:
2136:
2131:
2127:
2121:
2117:
2114:
2112:
2109:
2105:
2102:
2100:
2097:
2096:
2095:
2092:
2090:
2087:
2086:
2084:
2081:
2077:
2071:
2065:
2062:
2060:
2057:
2055:
2052:
2050:
2047:
2046:
2044:
2041:
2037:
2034:genitourinary
2031:
2025:
2022:
2020:
2017:
2015:
2014:Antipruritics
2012:
2010:
2007:
2005:
2002:
2001:
1999:
1996:
1992:
1988:
1980:
1977:
1975:
1972:
1970:
1967:
1966:
1965:
1962:
1958:
1955:
1953:
1950:
1948:
1945:
1944:
1943:
1942:
1938:
1936:
1933:
1931:
1930:Beta blockers
1928:
1926:
1923:
1921:
1918:
1916:
1913:
1909:
1906:
1904:
1901:
1899:
1896:
1895:
1894:
1893:
1888:
1887:
1885:
1882:
1878:
1872:
1864:
1861:
1859:
1856:
1854:
1851:
1850:
1849:
1846:
1842:
1839:
1837:
1834:
1832:
1831:Antiplatelets
1829:
1828:
1827:
1824:
1823:
1821:
1818:
1812:
1808:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1778:
1775:
1773:
1770:
1768:
1765:
1761:
1758:
1756:
1749:
1747:
1744:
1743:
1742:
1739:
1738:
1736:
1733:
1729:
1724:
1720:
1716:
1708:
1703:
1701:
1696:
1694:
1689:
1688:
1685:
1674:
1670:
1666:
1662:
1658:
1654:
1650:
1646:
1639:
1636:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1596:
1594:
1590:
1585:
1581:
1576:
1571:
1566:
1561:
1557:
1553:
1549:
1542:
1539:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1499:
1496:
1491:
1487:
1483:
1479:
1474:
1469:
1465:
1461:
1457:
1450:
1447:
1442:
1438:
1434:
1430:
1425:
1420:
1416:
1412:
1408:
1401:
1398:
1393:
1389:
1385:
1381:
1376:
1371:
1367:
1363:
1359:
1352:
1349:
1344:
1340:
1335:
1330:
1325:
1320:
1316:
1312:
1308:
1301:
1298:
1293:
1289:
1284:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1244:
1241:
1235:
1230:
1226:
1222:
1218:
1211:
1208:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1175:
1168:
1165:
1159:
1155:
1150:
1145:
1141:
1137:
1133:
1129:
1125:
1118:
1115:
1112:
1108:
1105:
1099:
1096:
1091:
1084:
1081:
1077:
1076:0-9578521-9-3
1073:
1069:
1068:
1061:
1059:
1055:
1050:
1046:
1042:
1038:
1034:
1030:
1022:
1019:
1014:
1010:
1005:
1000:
996:
992:
988:
984:
980:
973:
970:
957:
953:
947:
944:
939:
935:
930:
925:
921:
917:
914:(3): 601–55.
913:
909:
905:
898:
895:
891:
885:
881:
878:(5): 467–75.
877:
873:
865:
862:
849:
845:
841:
834:
831:
824:
820:
813:
811:
804:
803:
799:
797:
795:
785:
783:
779:
775:
774:metronidazole
771:
770:sulfonylureas
767:
763:
759:
755:
751:
747:
743:
739:
735:
731:
727:
723:
719:
715:
712:
708:
704:
700:
696:
692:
688:
684:
680:
676:
668:
664:
660:
653:
651:
631:
624:
613:
608:
606:
604:
595:
588:
586:
581:
577:
573:
569:
564:
550:
548:
547:antagonists.
542:
529:
513:
509:
506:
502:
500:
497:
494:
491:
489:disease (PUD)
488:
485:
484:
483:
482:, including:
481:
470:Clinical uses
469:
467:
461:
460:acetylcholine
457:
449:
445:
429:
427:
425:
416:
414:
410:
407:-ring with a
406:
402:
398:
395:receptor and
390:
386:
382:
376:
372:
368:
364:
360:
356:
351:
345:
337:
334:, a specific
333:
325:
316:
305:
300:
298:
294:
290:
278:
274:
271:
268:
265:
262:
259:
256:
253:
251:
248:
246:(Tazac, Axid)
245:
242:
239:
236:
233:
230:
227:
224:
223:
217:Class members
216:
214:
212:
208:
204:
200:
197:. The use of
196:
192:
188:
184:
180:
171:
169:
166:, due to the
165:
161:
149:
145:
137:
136:antihistamine
128:
126:
122:
114:
110:
106:
102:
98:
97:peptic ulcers
94:
86:
82:
78:
74:
66:
62:
58:
50:
46:
31:
27:
23:
19:
5363:Thioperamide
5267:Thioperamide
5207:Clobenpropit
5128:Immethridine
5031:Ramixotidine
5001:Niperotidine
4966:Isolamtidine
4926:Bisfentidine
4835:Trelnarizine
4815:Flotrenizine
4796:
4785:thioridazine
4777:perphenazine
4769:fluphenazine
4765:flupenthixol
4751:trimipramine
4715:clomipramine
4711:butriptyline
4697:oxaprotiline
4626:paliperidone
4598:aripiprazole
4590:
4534:Piclopastine
4464:Latrepirdine
4454:Flezelastine
4449:Fexofenadine
4434:Efletirizine
4340:
4334:Triprolidine
4324:Tolpropamine
4319:Thonzylamine
4314:Thiazinamium
4289:Propiomazine
4284:Promethazine
4254:Phenindamine
4234:Orphenadrine
4224:Methdilazine
4189:Isothipendyl
4139:Etodroxizine
4069:Cloperastine
3960:
3805:
3802:
3768:Combinations
3734:Sulglicotide
3674:Alginic acid
3592:Pantoprazole
3582:Lansoprazole
3572:Esomeprazole
3562:Azeloprazole
3555:("-prazole")
3453:peptic ulcer
3402:
3390:
3088:Serotonergic
3012:Dopaminergic
2891:
2491:Psychedelics
2461:Aphrodisiacs
2135:infestations
2111:Sex hormones
2064:Sex hormones
2009:Cicatrizants
1939:
1925:Vasodilators
1892:antianginals
1889:
1741:stomach acid
1740:
1648:
1644:
1638:
1605:
1601:
1555:
1551:
1541:
1508:
1504:
1498:
1463:
1459:
1449:
1414:
1410:
1400:
1365:
1361:
1351:
1314:
1310:
1300:
1257:
1253:
1243:
1224:
1220:
1210:
1177:
1173:
1167:
1134:(3): 310–9.
1131:
1127:
1117:
1098:
1089:
1083:
1065:
1032:
1028:
1021:
986:
982:
972:
960:. Retrieved
946:
911:
907:
897:
889:
875:
871:
864:
852:. Retrieved
843:
833:
786:
726:theophylline
672:
632:
625:
617:
602:
596:
589:
580:gynecomastia
565:
554:
525:
522:antagonists.
505:stress ulcer
487:Peptic ulcer
473:
433:
430:Pharmacology
417:
383:
381:antagonist.
352:
343:
323:
317:
301:
282:
267:niperotidine
172:
162:rather than
150:. Like the H
129:
85:stomach acid
52:
48:
40:
39:
18:
5348:JNJ-7777120
5341:Antagonists
5252:PF-03654746
5247:NNC 38-1049
5242:JNJ-5207852
5227:Impentamine
5192:Betahistine
5155:Antagonists
5108:Cipralisant
5071:Zolantidine
5061:Venritidine
4996:Mifentidine
4941:Dalcotidine
4919:Antagonists
4897:Impromidine
4825:Napactadine
4789:thiothixene
4739:lofepramine
4719:desipramine
4693:mirtazapine
4685:maprotiline
4638:ziprasidone
4634:risperidone
4618:iloperidone
4574:Terfenadine
4569:Temelastine
4519:Olopatadine
4509:Noberastine
4499:Mizolastine
4494:Mebhydrolin
4489:Mapinastine
4479:Linetastine
4394:Carebastine
4379:Bepotastine
4364:Bamirastine
4344:Acrivastine
4304:Thenalidine
4269:Pimethixene
4259:Pheniramine
4244:Oxomemazine
4209:Mequitazine
4199:Medrylamine
4179:Hydroxyzine
4159:Flunarizine
4154:Fenethazine
4149:Etymemazine
4114:Dimetindene
4089:Decloxizine
4064:Clocinizine
4059:Clobenzepam
4049:Cinnarizine
3994:Bepotastine
3969:Alimemazine
3954:Antagonists
3922:Betahistine
3830:from market
3739:Telenzepine
3714:Pirenzepine
3709:Lesogaberan
3704:Irsogladine
3669:Acetoxolone
3626:("-prazan")
3612:Timoprazole
3602:Rabeprazole
3597:Picoprazole
3537:Misoprostol
3530:("-prost-")
3476:("-tidine")
3474:antagonists
3404:Amino acids
3303:Opioidergic
3209:Cholinergic
2922:transporter
2902:Ion channel
2838:Transporter
2782:Ion channel
2624:Otologicals
2596:antagonists
2562:respiratory
2537:Orexigenics
2532:Neurotoxins
2481:Euphoriants
2471:Entactogens
2466:Depressants
2456:Anxiolytics
2394:Anesthetics
2170:Antifungals
1767:Antiemetics
1755:antagonists
1552:BMC Urology
1311:BMC Urology
1260:(1): 3899.
1180:(1): 7–20.
989:(1): 3–14.
892:1996;8:192.
742:propranolol
646:histamine H
568:hypotension
541:esophagitis
495:(GERD/GORD)
261:lavoltidine
144:antagonists
69:histamine H
61:medications
45:antagonists
5368:Toreforant
5358:Seliforant
5322:-Histidine
5257:Pitolisant
5237:Irdabisant
5222:GSK-189254
5202:Ciproxifan
5197:Burimamide
5141:Methimepip
5136:-Histidine
5056:Tuvatidine
5046:Sufotidine
5041:Roxatidine
5036:Ranitidine
5021:Pibutidine
5016:Oxmetidine
5006:Nizatidine
4986:Lupitidine
4971:Lafutidine
4961:Famotidine
4956:Etintidine
4951:Ebrotidine
4946:Donetidine
4936:Cimetidine
4931:Burimamide
4905:-Histidine
4830:Tagorizine
4820:GSK1004723
4810:Elbanizine
4805:Belarizine
4731:imipramine
4659:nefazodone
4630:quetiapine
4622:olanzapine
4579:Vapitadine
4549:Rupatadine
4529:Pibaxizine
4484:Loratadine
4444:Epinastine
4439:Emedastine
4404:Clemastine
4399:Cetirizine
4389:Cabastinen
4374:Bepiastine
4369:Barmastine
4359:Azelastine
4354:Astemizole
4349:Alinastine
4279:Pipoxizine
4129:Doxylamine
4094:Deptropine
4084:Dacemazine
4054:Clemastine
4034:Chlorothen
4014:Captodiame
3974:Antazoline
3940:-Histidine
3891:modulators
3803:See also:
3759:Zolimidine
3729:Sucralfate
3724:Rebamipide
3719:Proglumide
3648:Vonoprazan
3643:Soraprazan
3638:Revaprazan
3633:Linaprazan
3587:Omeprazole
3577:Ilaprazole
3513:Roxatidine
3508:Ranitidine
3503:Nizatidine
3493:Lafutidine
3488:Famotidine
3483:Cimetidine
3451:Drugs for
3252:Ganglionic
3243:Muscarinic
3221:Muscarinic
2944:Adrenergic
2813:Antagonist
2547:Stimulants
2527:Nootropics
2501:Deliriants
2476:Entheogens
2411:Anorectics
2389:Analgesics
2242:Alkylating
2175:Antivirals
2130:infections
2004:Emollients
1858:Coagulants
1728:metabolism
1558:(1): 115.
1227:: 100808.
1221:Continence
1102:Drugs.com
854:1 November
825:References
794:Famotidine
750:metoprolol
667:famotidine
424:omeprazole
385:Ranitidine
350:receptor.
332:burimamide
273:sufotidine
255:lafutidine
250:roxatidine
244:nizatidine
238:famotidine
232:ranitidine
226:cimetidine
203:ranitidine
179:cimetidine
125:cimetidine
121:ranitidine
115:than the H
109:omeprazole
30:cimetidine
5353:Mianserin
5314:Histamine
5262:SCH-79687
5217:Enerisant
5212:Conessine
5113:Histamine
5066:Xaltidine
5051:Tiotidine
5011:Osutidine
4991:Metiamide
4976:Lamtidine
4887:Histamine
4872:Amthamine
4840:Trenizine
4735:iprindole
4689:mianserin
4677:amoxapine
4663:trazodone
4614:clozapine
4602:asenapine
4584:Zepastine
4564:Talastine
4554:Setastine
4544:Rocastine
4524:Perastine
4514:Octastine
4504:Moxastine
4459:Ketotifen
4424:Dorastine
4409:Clemizole
4384:Bilastine
4299:Talastine
4274:Piperoxan
4249:Perlapine
4239:Oxatomide
4229:Moxastine
4194:Meclozine
4134:Embramine
4074:Cyclizine
4009:Buclizine
3999:Bromazine
3979:Azatadine
3927:Histamine
3840:Phase III
3828:Withdrawn
3749:Troxipide
3744:Teprenone
3699:Gefarnate
3694:Cetraxate
3542:Enprostil
3528:analogues
3457:GERD/GORD
3399:Precursor
3248:Nicotinic
3226:Nicotinic
3138:GABAergic
2863:Precursor
2848:Inhibitor
2774:Inhibitor
2697:ATC codes
2663:Dressings
2648:Antidotes
2512:Sedatives
2508:Hypnotics
2217:malignant
2074:endocrine
1920:Diuretics
1853:Platelets
1813:and blood
1772:Laxatives
1392:143433911
1202:251931004
754:methadone
746:labetalol
738:quinidine
734:lidocaine
730:phenytoin
585:impotence
499:Dyspepsia
401:imidazole
375:guanidine
359:metiamide
228:(Tagamet)
119:blockers
93:dyspepsia
73:receptors
65:histamine
5418:Category
5389:See also
5373:VUF-6002
5332:VUF-8430
5297:Agonists
5272:VUF-5681
5187:Bavisant
5167:A-423579
5162:A-349821
5146:Proxyfan
5096:Agonists
4882:Dimaprit
4877:Betazole
4865:Agonists
4800:Azanator
4773:loxapine
4681:loxapine
4642:zotepine
4429:Ebastine
3984:Bamipine
3910:Agonists
3387:Cofactor
3257:Muscular
2917:Receptor
2868:Cofactor
2854:Releaser
2842:Enhancer
2836:♦
2799:Receptor
2797:♦
2780:♦
2763:♦
2542:Serenics
2207:Vaccines
1974:Fibrates
1796:Vitamins
1746:Antacids
1673:10715649
1622:10491725
1584:31718622
1533:19989194
1525:11488726
1490:41415547
1482:11167643
1441:41415547
1433:11167643
1384:31049996
1343:19909543
1292:30846750
1194:36039014
1158:21173070
1107:Archived
1013:20978361
956:Archived
938:26084539
848:Archived
800:See also
784:(MDMA).
722:warfarin
609:Research
576:diarrhea
572:headache
528:antacids
444:receptor
409:nitrogen
371:thiourea
338:at the H
240:(Pepcid)
57:blockers
5182:AZD5213
5177:ABT-652
5172:ABT-239
5123:Immepip
4910:UR-AK49
4759:(e.g.,
4727:doxepin
4705:(e.g.,
4675:(e.g.,
4653:(e.g.,
4596:(e.g.,
4591:Others:
3945:UR-AK49
3344:(AdoRI)
3294:(eCBRI)
2877:Classes
2803:Agonist
2791:Blocker
2769:Inducer
2399:General
2306:muscles
2275:L03–L04
2271:disease
2223:L01–L02
2219:disease
1969:Statins
1665:6096071
1630:2089156
1575:6852726
1334:2781023
1283:6405771
1262:Bibcode
1149:3042441
1049:9314138
1004:4707670
962:7 April
929:4485016
884:7614110
778:ethanol
760:, some
695:CYP2C19
456:gastrin
191:Tagamet
81:stomach
79:in the
75:of the
67:at the
5327:OUP-16
5118:Imetit
3823:WHO-EM
3657:Others
3288:(eCBE)
2885:Enzyme
2786:Opener
2765:Enzyme
2706:
2685:
2633:other
2564:system
2316:joints
2269:immune
2076:system
2036:system
1877:system
1671:
1663:
1628:
1620:
1582:
1572:
1531:
1523:
1488:
1480:
1439:
1431:
1390:
1382:
1341:
1331:
1317:: 16.
1290:
1280:
1200:
1192:
1156:
1146:
1074:
1047:
1011:
1001:
936:
926:
882:
707:CYP3A4
703:CYP2E1
699:CYP2D6
691:CYP2C9
687:CYP1A2
207:Zantac
3401:(see
3389:(see
3335:Other
3158:(GRI)
3116:(SRI)
3032:(DRI)
3003:(NRI)
2919:&
2831:(NAM)
2825:(PAM)
2757:Types
2687:Drugs
2404:Local
2371:brain
2310:bones
1811:blood
1669:S2CID
1626:S2CID
1529:S2CID
1486:S2CID
1437:S2CID
1388:S2CID
1198:S2CID
718:toxic
711:serum
434:The H
405:furan
49:H2RAs
4892:HTMT
3932:HTMT
3525:(E)/
3461:A02B
3455:and
3189:NMDA
3179:AMPA
3105:5-HT
2907:See
2890:see
2856:(RA)
2850:(RI)
2844:(RE)
2314:and
1991:skin
1661:PMID
1618:PMID
1580:PMID
1521:PMID
1478:PMID
1429:PMID
1380:PMID
1339:PMID
1288:PMID
1190:PMID
1154:PMID
1128:CMAJ
1072:ISBN
1045:PMID
1009:PMID
964:2015
934:PMID
880:PMID
856:2017
780:and
530:or H
458:and
365:and
123:and
99:and
2635:ATC
2373:and
2132:and
1653:doi
1610:doi
1570:PMC
1560:doi
1513:doi
1468:doi
1419:doi
1370:doi
1329:PMC
1319:doi
1278:PMC
1270:doi
1229:doi
1182:doi
1144:PMC
1136:doi
1132:183
1037:doi
999:PMC
991:doi
924:PMC
916:doi
716:to
665:of
87:. H
28:of
5420::
4787:,
4783:,
4779:,
4775:,
4771:,
4767:,
4763:,
4749:,
4745:,
4741:,
4737:,
4733:,
4729:,
4725:,
4721:,
4717:,
4713:,
4709:,
4695:,
4691:,
4687:,
4683:,
4679:,
4665:,
4661:,
4657:,
4640:,
4636:,
4632:,
4628:,
4624:,
4620:,
4616:,
4612:,
4608:,
4604:,
4600:,
3836::
3358:NK
3259:))
3228:)
3129:AA
2972:))
2931:BA
2840::
2801::
2784::
2767::
2510:/
2308:,
2158::
2147:QI
2145:,
2141:,
2118:/
1779:/
1726:/
1667:.
1659:.
1647:.
1624:.
1616:.
1606:13
1604:.
1592:^
1578:.
1568:.
1556:19
1554:.
1550:.
1527:.
1519:.
1509:88
1507:.
1484:.
1476:.
1464:87
1462:.
1458:.
1435:.
1427:.
1415:87
1413:.
1409:.
1386:.
1378:.
1366:44
1364:.
1360:.
1337:.
1327:.
1313:.
1309:.
1286:.
1276:.
1268:.
1256:.
1252:.
1223:.
1219:.
1196:.
1188:.
1178:63
1176:.
1152:.
1142:.
1130:.
1126:.
1057:^
1043:.
1033:27
1031:.
1007:.
997:.
987:26
985:.
981:.
932:.
922:.
912:67
910:.
906:.
874:.
846:.
842:.
772:,
768:,
756:,
752:,
748:,
744:,
740:,
736:,
732:,
728:,
724:,
705:,
701:,
697:,
693:,
689:,
315:.
291:,
127:.
95:,
5320:L
5288:4
5286:H
5134:L
5087:3
5085:H
4903:L
4856:2
4854:H
4791:)
4753:)
4699:)
4669:)
4644:)
3938:L
3901:1
3899:H
3880:e
3873:t
3866:v
3472:2
3470:H
3463:)
3459:(
3444:e
3437:t
3430:v
3407:)
3395:)
3360:1
3250:(
3241:(
3219:(
3191:)
3187:(
3181:)
3177:(
3110:)
3107:3
3103:(
3079:)
3076:3
3074:H
3068:2
3066:H
3060:1
3058:H
3056:(
2997:)
2995:β
2991:)
2989:2
2984:1
2982:(
2980:α
2978:(
2970:2
2965:1
2963:(
2961:β
2956:α
2954:(
2935:M
2933:/
2742:e
2735:t
2728:v
2641:)
2639:V
2637:(
2612:)
2610:S
2608:(
2594:1
2592:H
2570:)
2568:R
2566:(
2382:)
2380:N
2378:(
2322:)
2320:M
2318:(
2312:,
2277:)
2273:(
2225:)
2221:(
2166:)
2162:(
2149:)
2143:P
2139:J
2137:(
2082:)
2080:H
2078:(
2042:)
2040:G
2038:(
1997:)
1995:D
1993:(
1883:)
1881:C
1879:(
1819:)
1817:B
1753:2
1751:H
1734:)
1732:A
1730:(
1706:e
1699:t
1692:v
1675:.
1655::
1649:9
1632:.
1612::
1586:.
1562::
1535:.
1515::
1492:.
1470::
1443:.
1421::
1394:.
1372::
1345:.
1321::
1315:9
1294:.
1272::
1264::
1258:9
1237:.
1231::
1225:7
1204:.
1184::
1160:.
1138::
1078:.
1051:.
1039::
1015:.
993::
966:.
940:.
918::
886:.
876:7
858:.
817:3
815:H
808:1
806:H
789:2
648:2
643:2
639:2
635:2
633:H
628:2
626:H
620:2
599:2
592:2
561:2
557:2
555:H
545:2
536:2
532:2
520:2
516:2
476:2
474:H
464:2
452:2
442:2
440:H
436:2
420:2
393:2
379:2
348:2
344:N
340:2
328:2
324:N
320:2
313:2
309:1
307:H
285:2
175:2
156:2
152:1
142:1
140:H
132:2
130:H
117:2
89:2
71:2
55:2
53:H
43:2
41:H
34:2
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
