328:
2232:
2187:
2217:
3391:
2202:
35:
1112:
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van
Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan
1532:
Ranaldi S, Belle V, Woudstra M, Bourgeas R, Guigliarelli B, Roche P, Vezin H, Carrière F, Fournel A (2010). "Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular
244:
The most conserved region in all these proteins is centred on a serine residue which has been shown to participate, with a histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase
1236:
Lessinger JM, Arzoglou P, Ramos P, Visvikis A, Parashou S, Calam D, Profilis C, Férard G (2003). "Preparation and characterization of reference materials for human pancreatic lipase: BCR 693 (from human pancreatic juice) and BCR 694 (recombinant)".
1303:
Ramos P, Coste T, Piémont E, Lessinger JM, Bousquet JA, Chapus C, Kerfelec B, Férard G, Mély Y (2003). "Time-resolved fluorescence allows selective monitoring of Trp30 environmental changes in the seven-Trp-containing human pancreatic lipase".
1082:
Ranaldi S, Belle V, Woudstra M, Rodriguez J, Guigliarelli B, Sturgis J, Carriere F, Fournel A (2009). "Lid opening and unfolding in human pancreatic lipase at low pH revealed by site-directed spin labeling EPR and FTIR spectroscopy".
1428:
Belle V, Fournel A, Woudstra M, Ranaldi S, Prieri F, Thomé V, Currault J, Verger R, Guigliarelli B, Carrière F (2007). "Probing the opening of the pancreatic lipase lid using site-directed spin labeling and EPR spectroscopy".
2231:
576:"Structural features of lipoprotein lipase. Lipase family relationships, binding interactions, non-equivalence of lipase cofactors, vitellogenin similarities and functional subdivision of lipoprotein lipase"
1489:"Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt"
2186:
1597:
1191:
van
Tilbeurgh H, Egloff MP, Martinez C, Rugani N, Verger R, Cambillau C (1993). "Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography".
1391:
Grandval P, De Caro A, De Caro J, Sias B, Carrière F, Verger R, Laugier R (2004). "Critical evaluation of a specific ELISA and two enzymatic assays of pancreatic lipases in human sera".
491:
and release pancreatic enzymes including pancreatic lipase into serum. Thus, through measurement of serum concentration of pancreatic lipase, acute pancreatitis can be diagnosed.
746:
Davis RC, Diep A, Hunziker W, Klisak I, Mohandas T, Schotz MC, Sparkes RS, Lusis AJ (December 1991). "Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26".
177:
1590:
133:
121:
1362:
Sims HF, Jennens ML, Lowe ME (1993). "The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family".
1583:
479:
through the duct system of the pancreas. Its concentration in serum is normally very low. Under extreme disruption of pancreatic function, such as
2465:
230:
exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (
2712:
2166:
101:
2216:
2626:
1053:
Chahinian H, Sias B, Carrière F (2000). "The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains".
2727:
2721:
2522:
2272:
1895:
1274:
Colin DY, Deprez-Beauclair P, Allouche M, Brasseur R, Kerfelec B (2008). "Exploring the active site cavity of human pancreatic lipase".
975:"Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles"
223:
of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are widely distributed in animals, plants and prokaryotes.
2570:
847:
3110:
2681:
2470:
733:
781:
940:"Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles"
2788:
2676:
2597:
2507:
2460:
3266:
1333:
Yang Y, Lowe ME (1998). "Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization".
197:
3019:
2960:
2096:
1852:
3381:
2240:: The 2.46 Ångströms resolution structure of the pancreatic lipase colipase complex inhibited by a c11 alkyl phosphonate.
3064:
2631:
2621:
3024:
2916:
2541:
1788:
1750:
2610:
2606:
2602:
2518:
2351:
2129:
3251:
1680:
3421:
3367:
3354:
3341:
3328:
3315:
3302:
3289:
2872:
2818:
2778:
2737:
2641:
2480:
2448:
2334:
2298:
2159:
1957:
3261:
3416:
3215:
3158:
2526:
2375:
2289:
2195:: Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by x-ray crystallography.
1830:
1115:"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease"
246:
231:
213:
830:
327:
185:
3163:
2395:
2265:
1825:
1693:
1658:
238:
2951:
2590:
2091:
1945:
1783:
1745:
392:), pancreatic lipase is secreted in its final form. However, it becomes efficient only in the presence of
3184:
3103:
2886:
2783:
2575:
2536:
2400:
2322:
1885:
1862:
1847:
1778:
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181:
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2899:
2832:
2492:
2317:
2152:
2083:
1940:
1928:
1905:
1760:
1628:
1200:
861:"Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies"
679:
624:
385:
114:
3220:
2924:
2894:
2698:
2693:
2617:
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2339:
2201:
1921:
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1813:
1653:
488:
3153:
3057:
2909:
2390:
2380:
2258:
1638:
1416:
1262:
1224:
728:, S. Hirzel Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2. Auflage, 1990, S. 308−309,
648:
439:
795:
Koop H (September 1984). "Serum levels of pancreatic enzymes and their clinical significance".
3411:
2858:
2803:
2771:
2646:
2365:
2023:
2002:
1670:
1665:
1550:
1520:
1475:
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1408:
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1216:
1179:
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961:
926:
882:
812:
763:
729:
707:
640:
597:
556:
539:
Chapus C, Rovery M, Sarda L, Verger R (1988). "Minireview on pancreatic lipase and colipase".
484:
464:
459:
454:
172:
40:
3199:
3194:
3168:
3096:
2934:
2514:
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1770:
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1510:
1500:
1467:
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1400:
1371:
1342:
1313:
1283:
1246:
1208:
1169:
1134:
1126:
1092:
1062:
1031:
1020:"Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits"
996:
986:
951:
916:
872:
804:
755:
697:
687:
632:
587:
548:
444:
374:
295:
361:
of the fat, which allows the lipase to break apart the fat more effectively. The resulting
252:) (LCAT), which catalyzes fatty acid transfer between phosphatidylcholine and cholesterol.
164:
3246:
3230:
3143:
3036:
2850:
2766:
2761:
2756:
2669:
2664:
2424:
2302:
2106:
2101:
370:
314:
1204:
683:
628:
3395:
3284:
3225:
3009:
3004:
2999:
2385:
2360:
2356:
2329:
2312:
2014:
1870:
1643:
1633:
1515:
1488:
1139:
1114:
1001:
974:
666:
McLean J, Fielding C, Drayna D, Dieplinger H, Baer B, Kohr W, Henzel W, Lawn R (1986).
592:
575:
421:
220:
126:
17:
808:
702:
667:
3405:
3189:
3148:
2750:
2659:
2409:
2057:
2036:
1950:
1875:
1808:
1375:
759:
552:
307:
106:
1575:
1420:
1266:
70:
3138:
2877:
2808:
2531:
2452:
2062:
2031:
1934:
1835:
1623:
1228:
652:
480:
358:
299:
160:
1471:
138:
1571:
82:
3362:
3297:
3133:
3052:
2823:
2717:
2580:
2546:
2484:
2250:
1880:
1840:
1820:
1755:
1717:
1708:
1703:
1698:
1615:
1113:
M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006).
574:
Persson B, Bengtsson-Olivecrona G, Enerback S, Olivecrona T, Jornvall H (1989).
431:
389:
366:
346:
3390:
1287:
877:
860:
3029:
1800:
1740:
1727:
1648:
1607:
506:
One peptide selected by phage display was found to inhibit pancreatic lipase.
338:
284:
1066:
921:
904:
903:
Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C, Lowe M (November 1998).
3336:
3310:
2942:
2741:
2654:
2281:
1972:
1967:
1962:
1890:
1688:
1458:
Lowe ME (1997). "Structure and function of pancreatic lipase and colipase".
291:
1554:
1524:
1505:
1450:
1412:
1346:
1325:
1295:
1258:
1183:
1174:
1157:
1148:
1104:
1074:
1045:
1018:
Hegele RA, Ramdath DD, Ban MR, Carruthers MN, Carrington CV, Cao H (2001).
1010:
991:
965:
956:
939:
886:
692:
668:"Cloning and expression of human lecithin-cholesterol acyltransferase cDNA"
1479:
1383:
1354:
1250:
1220:
1036:
1019:
930:
816:
767:
711:
644:
601:
560:
110:
2987:
2982:
2977:
2798:
2433:
2285:
2052:
1984:
1735:
1567:
515:
500:
476:
397:
393:
365:(2 free fatty acids and one 2-monoacylglycerol) are then moved by way of
362:
354:
350:
276:
77:
44:
249:
234:
2994:
2972:
2967:
2585:
1992:
519:
378:
227:
216:
94:
89:
1546:
1442:
1404:
1317:
1158:"Role of the lid hydrophobicity pattern in pancreatic lipase activity"
1096:
357:
large fat droplets into smaller droplets, thus increasing the overall
3349:
3119:
3014:
2947:
2840:
2438:
2346:
1997:
1212:
636:
280:
272:
192:
34:
1130:
905:"Structure and activity of rat pancreatic lipase-related protein 2"
3323:
2956:
2707:
2703:
449:
342:
326:
2688:
2565:
2558:
2502:
2497:
1563:
426:
409:
154:
65:
3092:
2254:
2148:
1579:
2144:
1156:
Thomas A, Allouche M, Basyn F, Brasseur R, Kerfelec B (2005).
288:
859:
Lunder, M.; Bratkovič, T.; Kreft, S.; Štrukelj, B. (2005).
237:), which hydrolyses triglycerides of chylomicrons and very
3088:
615:
Blow D (1990). "Enzymology. More of the catalytic triad".
1562:
This article incorporates text from the public domain
3379:
2225:: Structure of the pancreatic lipase-colipase complex
384:
Unlike some pancreatic enzymes that are activated by
294:
in the human digestive system, it is one of the main
3275:
3239:
3208:
3177:
3126:
3045:
2933:
2885:
2871:
2849:
2831:
2817:
2797:
2736:
2640:
2479:
2447:
2297:
2122:
2082:
2075:
2045:
2022:
2013:
1983:
1904:
1861:
1799:
1769:
1726:
1679:
1614:
518:(a pancreatic lipase inhibitor marketed as an anti-
191:
171:
153:
148:
132:
120:
100:
88:
76:
64:
56:
51:
2576:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
1487:Bourbon-Freie A, Dub RE, Xiao X, Lowe ME (2009).
973:Freie AB, Ferrato F, Carrière F, Lowe ME (2006).
403:In humans, pancreatic lipase is encoded by the
3104:
2266:
2160:
1591:
8:
3111:
3097:
3089:
2882:
2828:
2814:
2273:
2259:
2251:
2167:
2153:
2145:
2079:
2019:
1598:
1584:
1576:
145:
1514:
1504:
1173:
1138:
1035:
1000:
990:
955:
920:
876:
701:
691:
591:
503:can be used as a treatment for obesity.
3386:
2466:Ubiquitin carboxy-terminal hydrolase L1
2182:
531:
475:Pancreatic lipase is secreted into the
27:Mammalian protein found in Homo sapiens
29:
3046:either deoxy- or ribo-
416:Human proteins containing this domain
7:
2627:Protein serine/threonine phosphatase
2728:Cyclic nucleotide phosphodiesterase
2722:Clostridium perfringens alpha toxin
2523:Tartrate-resistant acid phosphatase
1896:Glycogen phosphorylase isoenzyme BB
2571:Pyruvate dehydrogenase phosphatase
593:10.1111/j.1432-1033.1989.tb14518.x
25:
2471:4-hydroxybenzoyl-CoA thioesterase
377:by a specialized vessel called a
265:pancreatic triacylglycerol lipase
3389:
2230:
2215:
2200:
2185:
1399:(6): 495–503, discussion 503–4.
782:"Entrez Gene: pancreatic lipase"
33:
2789:N-acetylglucosamine-6-sulfatase
2677:Sphingomyelin phosphodiesterase
226:At least three tissue-specific
2598:Inositol-phosphate phosphatase
2461:Palmitoyl protein thioesterase
1:
2961:RNA-induced silencing complex
1853:Comprehensive metabolic panel
1472:10.1146/annurev.nutr.17.1.141
1276:Biochem. Biophys. Res. Commun
938:Crandall WV, Lowe ME (2001).
848:FDA index page for NDA 020766
809:10.1016/S0300-5089(21)00756-2
331:Hydrolysis of a triglyceride
149:Available protein structures:
3065:Serratia marcescens nuclease
2632:Dual-specificity phosphatase
2622:Protein tyrosine phosphatase
1376:10.1016/0378-1119(93)90307-O
760:10.1016/0888-7543(91)90048-J
672:Proc. Natl. Acad. Sci. U.S.A
553:10.1016/0300-9084(88)90188-5
487:, the pancreas may begin to
2542:Fructose 1,6-bisphosphatase
1789:Thyroid-stimulating hormone
1751:Total iron-binding capacity
3438:
2130:Elevated alpha-fetoprotein
1561:
1288:10.1016/j.bbrc.2008.03.043
878:10.1194/jlr.M500048-JLR200
499:Lipase inhibitors such as
306:found in ingested oils to
3267:Michaelis–Menten kinetics
2779:Galactosamine-6 sulfatase
2335:6-phosphogluconolactonase
2180:
865:Journal of Lipid Research
485:pancreatic adenocarcinoma
144:
32:
3159:Diffusion-limited enzyme
2527:Purple acid phosphatases
1067:10.2174/1389203003381487
922:10.1074/jbc.273.48.32121
373:to be absorbed into the
239:low density lipoproteins
1659:BUN-to-creatinine ratio
1055:Curr. Protein Pept. Sci
256:Human pancreatic lipase
18:Human pancreatic lipase
2952:Microprocessor complex
2591:Beta-propeller phytase
2092:Elevated transaminases
1784:Thyroid function tests
1746:Transferrin saturation
1606:Clinical biochemistry
1506:10.1074/jbc.M901154200
1347:10.1006/prep.1998.0874
1175:10.1074/jbc.M502123200
992:10.1074/jbc.M512984200
957:10.1074/jbc.M009986200
846:For label updates see
693:10.1073/pnas.83.8.2335
353:, where they coat and
349:are released into the
335:
287:(breaks down) dietary
3252:Eadie–Hofstee diagram
3185:Allosteric regulation
2887:Endodeoxyribonuclease
2784:Iduronate-2-sulfatase
2537:Glucose 6-phosphatase
2323:Butyrylcholinesterase
1886:Lactate dehydrogenase
1848:Basic metabolic panel
1779:ACTH stimulation test
1251:10.1515/CCLM.2003.028
1037:10.1007/s100380170066
471:Diagnostic importance
330:
3262:Lineweaver–Burk plot
3070:Micrococcal nuclease
2905:Deoxyribonuclease IV
2900:Deoxyribonuclease II
2833:Exodeoxyribonuclease
2493:Alkaline phosphatase
2318:Acetylcholinesterase
1906:Liver function tests
1761:Transferrin receptor
1239:Clin. Chem. Lab. Med
386:proteolytic cleavage
210:Triglyceride lipases
2925:UvrABC endonuclease
2895:Deoxyribonuclease I
2618:Protein phosphatase
2554:Protein phosphatase
2352:Bile salt-dependent
2340:PAF acetylhydrolase
1922:Serum total protein
1917:Human serum albumin
1335:Protein Expr. Purif
1205:1993Natur.362..814V
831:"US orlistat label"
684:1986PNAS...83.2335M
629:1990Natur.343..694B
3221:Enzyme superfamily
3154:Enzyme promiscuity
3058:Mung bean nuclease
2917:Restriction enzyme
2910:Restriction enzyme
1694:Arterial blood gas
836:. FDA. August 2015
797:Clin Gastroenterol
341:secreted from the
336:
275:secreted from the
3377:
3376:
3086:
3085:
3082:
3081:
3078:
3077:
2867:
2866:
2859:Oligonucleotidase
2804:deoxyribonuclease
2772:Steroid sulfatase
2647:Phosphodiesterase
2376:Hormone-sensitive
2248:
2247:
2142:
2141:
2138:
2137:
2071:
2070:
2024:Blood sugar level
2003:Pancreatic lipase
1841:Total cholesterol
1671:Serum osmolal gap
1666:Plasma osmolality
1547:10.1021/bi901918f
1443:10.1021/bi0616089
1405:10.1159/000080246
1318:10.1021/bi034900e
1119:Am. J. Hum. Genet
1097:10.1021/bi801250s
623:(6260): 694–695.
296:digestive enzymes
279:. As the primary
261:Pancreatic lipase
207:
206:
203:
202:
198:structure summary
41:pancreatic lipase
39:Complex of human
16:(Redirected from
3429:
3422:Protein families
3394:
3393:
3385:
3257:Hanes–Woolf plot
3200:Enzyme activator
3195:Enzyme inhibitor
3169:Enzyme catalysis
3113:
3106:
3099:
3090:
2935:Endoribonuclease
2921:
2915:
2883:
2829:
2815:
2515:Acid phosphatase
2396:Monoacylglycerol
2306:ester hydrolases
2275:
2268:
2261:
2252:
2234:
2219:
2204:
2189:
2169:
2162:
2155:
2146:
2114:Hyperproteinemia
2080:
2020:
1600:
1593:
1586:
1577:
1558:
1528:
1518:
1508:
1499:(21): 14157–64.
1483:
1454:
1424:
1387:
1358:
1329:
1312:(43): 12488–96.
1299:
1270:
1232:
1213:10.1038/362814a0
1199:(6423): 814–20.
1187:
1177:
1168:(48): 40074–83.
1152:
1142:
1108:
1078:
1049:
1039:
1014:
1004:
994:
985:(12): 7793–800.
969:
959:
950:(16): 12505–12.
934:
924:
891:
890:
880:
871:(7): 1512–1516.
856:
850:
845:
843:
841:
835:
827:
821:
820:
792:
786:
785:
778:
772:
771:
743:
737:
726:Naturstoffchemie
722:
716:
715:
705:
695:
678:(8): 2335–2339.
663:
657:
656:
637:10.1038/343694a0
612:
606:
605:
595:
571:
565:
564:
547:(9): 1223–1234.
536:
375:lymphatic system
315:free fatty acids
302:substrates like
263:, also known as
146:
37:
30:
21:
3437:
3436:
3432:
3431:
3430:
3428:
3427:
3426:
3417:Protein domains
3402:
3401:
3400:
3388:
3380:
3378:
3373:
3285:Oxidoreductases
3271:
3247:Enzyme kinetics
3235:
3231:List of enzymes
3204:
3173:
3144:Catalytic triad
3122:
3117:
3087:
3074:
3041:
2929:
2919:
2913:
2876:
2863:
2851:Exoribonuclease
2845:
2822:
2806:
2802:
2793:
2767:Arylsulfatase L
2762:Arylsulfatase B
2757:Arylsulfatase A
2732:
2645:
2636:
2475:
2443:
2305:
2293:
2279:
2249:
2244:
2241:
2235:
2226:
2220:
2211:
2205:
2196:
2190:
2176:
2173:
2143:
2134:
2118:
2107:Hypoalbuminemia
2102:Hypoproteinemia
2067:
2041:
2015:Small molecules
2009:
1979:
1900:
1857:
1795:
1765:
1722:
1712:
1675:
1610:
1604:
1574:
1531:
1486:
1460:Annu. Rev. Nutr
1457:
1427:
1390:
1361:
1332:
1302:
1273:
1235:
1190:
1155:
1111:
1081:
1052:
1017:
972:
937:
915:(48): 32121–8.
902:
899:
897:Further reading
894:
858:
857:
853:
839:
837:
833:
829:
828:
824:
794:
793:
789:
780:
779:
775:
745:
744:
740:
723:
719:
665:
664:
660:
614:
613:
609:
580:Eur. J. Biochem
573:
572:
568:
538:
537:
533:
529:
512:
497:
473:
418:
371:small intestine
258:
122:OPM superfamily
47:
28:
23:
22:
15:
12:
11:
5:
3435:
3433:
3425:
3424:
3419:
3414:
3404:
3403:
3399:
3398:
3375:
3374:
3372:
3371:
3358:
3345:
3332:
3319:
3306:
3293:
3279:
3277:
3273:
3272:
3270:
3269:
3264:
3259:
3254:
3249:
3243:
3241:
3237:
3236:
3234:
3233:
3228:
3223:
3218:
3212:
3210:
3209:Classification
3206:
3205:
3203:
3202:
3197:
3192:
3187:
3181:
3179:
3175:
3174:
3172:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3130:
3128:
3124:
3123:
3118:
3116:
3115:
3108:
3101:
3093:
3084:
3083:
3080:
3079:
3076:
3075:
3073:
3072:
3067:
3062:
3061:
3060:
3049:
3047:
3043:
3042:
3040:
3039:
3034:
3033:
3032:
3027:
3022:
3017:
3007:
3002:
2997:
2992:
2991:
2990:
2985:
2980:
2975:
2965:
2964:
2963:
2954:
2939:
2937:
2931:
2930:
2928:
2927:
2922:
2907:
2902:
2897:
2891:
2889:
2880:
2869:
2868:
2865:
2864:
2862:
2861:
2855:
2853:
2847:
2846:
2844:
2843:
2837:
2835:
2826:
2812:
2795:
2794:
2792:
2791:
2786:
2781:
2776:
2775:
2774:
2769:
2764:
2759:
2746:
2744:
2734:
2733:
2731:
2730:
2725:
2715:
2710:
2701:
2696:
2691:
2686:
2685:
2684:
2674:
2673:
2672:
2667:
2657:
2651:
2649:
2638:
2637:
2635:
2634:
2629:
2624:
2615:
2614:
2613:
2595:
2594:
2593:
2583:
2578:
2573:
2568:
2563:
2562:
2561:
2551:
2550:
2549:
2539:
2534:
2529:
2512:
2511:
2510:
2505:
2500:
2489:
2487:
2477:
2476:
2474:
2473:
2468:
2463:
2457:
2455:
2445:
2444:
2442:
2441:
2436:
2430:
2429:
2428:
2427:
2422:
2417:
2406:
2405:
2404:
2403:
2401:Diacylglycerol
2398:
2393:
2388:
2383:
2378:
2373:
2368:
2363:
2354:
2343:
2342:
2337:
2332:
2330:Pectinesterase
2327:
2326:
2325:
2320:
2313:Cholinesterase
2309:
2307:
2295:
2294:
2280:
2278:
2277:
2270:
2263:
2255:
2246:
2245:
2243:
2242:
2236:
2229:
2227:
2221:
2214:
2212:
2206:
2199:
2197:
2191:
2184:
2181:
2178:
2177:
2174:
2172:
2171:
2164:
2157:
2149:
2140:
2139:
2136:
2135:
2133:
2132:
2126:
2124:
2120:
2119:
2117:
2116:
2111:
2110:
2109:
2099:
2094:
2088:
2086:
2077:
2073:
2072:
2069:
2068:
2066:
2065:
2060:
2055:
2049:
2047:
2043:
2042:
2040:
2039:
2034:
2028:
2026:
2017:
2011:
2010:
2008:
2007:
2006:
2005:
1995:
1989:
1987:
1981:
1980:
1978:
1977:
1976:
1975:
1970:
1960:
1955:
1954:
1953:
1948:
1943:
1931:
1926:
1925:
1924:
1919:
1910:
1908:
1902:
1901:
1899:
1898:
1893:
1888:
1883:
1878:
1873:
1871:Cardiac marker
1867:
1865:
1863:Cardiovascular
1859:
1858:
1856:
1855:
1850:
1845:
1844:
1843:
1838:
1833:
1828:
1818:
1817:
1816:
1814:Hemoglobin A1c
1805:
1803:
1797:
1796:
1794:
1793:
1792:
1791:
1781:
1775:
1773:
1767:
1766:
1764:
1763:
1758:
1753:
1748:
1743:
1738:
1732:
1730:
1724:
1723:
1721:
1720:
1715:
1710:
1706:
1701:
1696:
1691:
1685:
1683:
1677:
1676:
1674:
1673:
1668:
1663:
1662:
1661:
1656:
1651:
1644:Renal function
1641:
1636:
1631:
1626:
1620:
1618:
1612:
1611:
1605:
1603:
1602:
1595:
1588:
1580:
1560:
1559:
1541:(10): 2140–9.
1529:
1484:
1455:
1437:(8): 2205–14.
1425:
1388:
1359:
1330:
1300:
1271:
1233:
1188:
1153:
1131:10.1086/498851
1109:
1079:
1050:
1015:
970:
935:
898:
895:
893:
892:
851:
822:
787:
773:
738:
717:
658:
607:
566:
530:
528:
525:
524:
523:
511:
508:
496:
493:
472:
469:
468:
467:
462:
457:
452:
447:
442:
437:
434:
429:
424:
417:
414:
345:and stored in
308:monoglycerides
257:
254:
205:
204:
201:
200:
195:
189:
188:
175:
169:
168:
158:
151:
150:
142:
141:
136:
130:
129:
124:
118:
117:
104:
98:
97:
92:
86:
85:
80:
74:
73:
68:
62:
61:
58:
54:
53:
49:
48:
38:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3434:
3423:
3420:
3418:
3415:
3413:
3410:
3409:
3407:
3397:
3392:
3387:
3383:
3369:
3365:
3364:
3359:
3356:
3352:
3351:
3346:
3343:
3339:
3338:
3333:
3330:
3326:
3325:
3320:
3317:
3313:
3312:
3307:
3304:
3300:
3299:
3294:
3291:
3287:
3286:
3281:
3280:
3278:
3274:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3248:
3245:
3244:
3242:
3238:
3232:
3229:
3227:
3226:Enzyme family
3224:
3222:
3219:
3217:
3214:
3213:
3211:
3207:
3201:
3198:
3196:
3193:
3191:
3190:Cooperativity
3188:
3186:
3183:
3182:
3180:
3176:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3149:Oxyanion hole
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3131:
3129:
3125:
3121:
3114:
3109:
3107:
3102:
3100:
3095:
3094:
3091:
3071:
3068:
3066:
3063:
3059:
3056:
3055:
3054:
3051:
3050:
3048:
3044:
3038:
3035:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3012:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2970:
2969:
2966:
2962:
2958:
2955:
2953:
2949:
2946:
2945:
2944:
2941:
2940:
2938:
2936:
2932:
2926:
2923:
2918:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2892:
2890:
2888:
2884:
2881:
2879:
2874:
2870:
2860:
2857:
2856:
2854:
2852:
2848:
2842:
2839:
2838:
2836:
2834:
2830:
2827:
2825:
2820:
2816:
2813:
2810:
2805:
2800:
2796:
2790:
2787:
2785:
2782:
2780:
2777:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2754:
2753:
2752:
2751:arylsulfatase
2748:
2747:
2745:
2743:
2739:
2735:
2729:
2726:
2723:
2719:
2716:
2714:
2711:
2709:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2683:
2680:
2679:
2678:
2675:
2671:
2668:
2666:
2663:
2662:
2661:
2660:Phospholipase
2658:
2656:
2653:
2652:
2650:
2648:
2643:
2639:
2633:
2630:
2628:
2625:
2623:
2619:
2616:
2612:
2608:
2604:
2601:
2600:
2599:
2596:
2592:
2589:
2588:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2560:
2557:
2556:
2555:
2552:
2548:
2545:
2544:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2524:
2520:
2516:
2513:
2509:
2506:
2504:
2501:
2499:
2496:
2495:
2494:
2491:
2490:
2488:
2486:
2482:
2478:
2472:
2469:
2467:
2464:
2462:
2459:
2458:
2456:
2454:
2450:
2446:
2440:
2437:
2435:
2432:
2431:
2426:
2423:
2421:
2418:
2416:
2413:
2412:
2411:
2410:Phospholipase
2408:
2407:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2362:
2358:
2355:
2353:
2350:
2349:
2348:
2345:
2344:
2341:
2338:
2336:
2333:
2331:
2328:
2324:
2321:
2319:
2316:
2315:
2314:
2311:
2310:
2308:
2304:
2300:
2296:
2291:
2287:
2283:
2276:
2271:
2269:
2264:
2262:
2257:
2256:
2253:
2239:
2233:
2228:
2224:
2218:
2213:
2209:
2203:
2198:
2194:
2188:
2183:
2179:
2170:
2165:
2163:
2158:
2156:
2151:
2150:
2147:
2131:
2128:
2127:
2125:
2121:
2115:
2112:
2108:
2105:
2104:
2103:
2100:
2098:
2095:
2093:
2090:
2089:
2087:
2085:
2081:
2078:
2074:
2064:
2061:
2059:
2058:Hyperuricemia
2056:
2054:
2051:
2050:
2048:
2044:
2038:
2037:Hyperglycemia
2035:
2033:
2030:
2029:
2027:
2025:
2021:
2018:
2016:
2012:
2004:
2001:
2000:
1999:
1996:
1994:
1991:
1990:
1988:
1986:
1982:
1974:
1971:
1969:
1966:
1965:
1964:
1961:
1959:
1956:
1952:
1951:AST/ALT ratio
1949:
1947:
1944:
1942:
1939:
1938:
1937:
1936:
1935:transaminases
1932:
1930:
1927:
1923:
1920:
1918:
1915:
1914:
1912:
1911:
1909:
1907:
1903:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1876:Troponin test
1874:
1872:
1869:
1868:
1866:
1864:
1860:
1854:
1851:
1849:
1846:
1842:
1839:
1837:
1836:Triglycerides
1834:
1832:
1829:
1827:
1824:
1823:
1822:
1819:
1815:
1812:
1811:
1810:
1809:Blood glucose
1807:
1806:
1804:
1802:
1798:
1790:
1787:
1786:
1785:
1782:
1780:
1777:
1776:
1774:
1772:
1768:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1733:
1731:
1729:
1725:
1719:
1716:
1714:
1707:
1705:
1702:
1700:
1697:
1695:
1692:
1690:
1687:
1686:
1684:
1682:
1678:
1672:
1669:
1667:
1664:
1660:
1657:
1655:
1652:
1650:
1647:
1646:
1645:
1642:
1640:
1637:
1635:
1632:
1630:
1627:
1625:
1622:
1621:
1619:
1617:
1613:
1609:
1601:
1596:
1594:
1589:
1587:
1582:
1581:
1578:
1573:
1569:
1565:
1556:
1552:
1548:
1544:
1540:
1536:
1530:
1526:
1522:
1517:
1512:
1507:
1502:
1498:
1494:
1493:J. Biol. Chem
1490:
1485:
1481:
1477:
1473:
1469:
1465:
1461:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1393:Pancreatology
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1360:
1356:
1352:
1348:
1344:
1340:
1336:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1301:
1297:
1293:
1289:
1285:
1281:
1277:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1245:(2): 169–76.
1244:
1240:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1189:
1185:
1181:
1176:
1171:
1167:
1163:
1162:J. Biol. Chem
1159:
1154:
1150:
1146:
1141:
1136:
1132:
1128:
1124:
1120:
1116:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1080:
1076:
1072:
1068:
1064:
1061:(1): 91–103.
1060:
1056:
1051:
1047:
1043:
1038:
1033:
1029:
1025:
1024:J. Hum. Genet
1021:
1016:
1012:
1008:
1003:
998:
993:
988:
984:
980:
979:J. Biol. Chem
976:
971:
967:
963:
958:
953:
949:
945:
944:J. Biol. Chem
941:
936:
932:
928:
923:
918:
914:
910:
909:J. Biol. Chem
906:
901:
900:
896:
888:
884:
879:
874:
870:
866:
862:
855:
852:
849:
832:
826:
823:
818:
814:
810:
806:
803:(3): 739–61.
802:
798:
791:
788:
783:
777:
774:
769:
765:
761:
757:
754:(4): 1164–6.
753:
749:
742:
739:
735:
734:3-7776-0473-9
731:
727:
721:
718:
713:
709:
704:
699:
694:
689:
685:
681:
677:
673:
669:
662:
659:
654:
650:
646:
642:
638:
634:
630:
626:
622:
618:
611:
608:
603:
599:
594:
589:
585:
581:
577:
570:
567:
562:
558:
554:
550:
546:
542:
535:
532:
526:
521:
517:
514:
513:
509:
507:
504:
502:
494:
492:
490:
486:
482:
478:
470:
466:
463:
461:
458:
456:
453:
451:
448:
446:
443:
441:
438:
435:
433:
430:
428:
425:
423:
420:
419:
415:
413:
411:
408:
407:
401:
399:
395:
391:
387:
382:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
334:
329:
325:
323:
319:
316:
312:
309:
305:
301:
298:, converting
297:
293:
290:
286:
283:enzyme that
282:
278:
274:
270:
266:
262:
255:
253:
251:
248:
242:
240:
236:
233:
229:
224:
222:
218:
215:
211:
199:
196:
194:
190:
187:
183:
179:
176:
174:
170:
166:
162:
159:
156:
152:
147:
143:
140:
137:
135:
131:
128:
125:
123:
119:
116:
112:
108:
105:
103:
99:
96:
93:
91:
87:
84:
81:
79:
75:
72:
69:
67:
63:
59:
55:
50:
46:
42:
36:
31:
19:
3363:Translocases
3360:
3347:
3334:
3321:
3308:
3298:Transferases
3295:
3282:
3139:Binding site
2920:}}
2914:{{
2878:Endonuclease
2809:ribonuclease
2749:
2532:Nucleotidase
2453:Thioesterase
2237:
2222:
2210:: RP2 LIPASE
2207:
2192:
2097:Elevated ALP
2063:Hypouricemia
2032:Hypoglycemia
1968:Unconjugated
1933:
1616:Electrolytes
1538:
1535:Biochemistry
1534:
1496:
1492:
1463:
1459:
1434:
1431:Biochemistry
1430:
1396:
1392:
1370:(2): 281–5.
1367:
1363:
1341:(1): 36–40.
1338:
1334:
1309:
1306:Biochemistry
1305:
1282:(3): 394–8.
1279:
1275:
1242:
1238:
1196:
1192:
1165:
1161:
1125:(1): 78–88.
1122:
1118:
1091:(3): 630–8.
1088:
1085:Biochemistry
1084:
1058:
1054:
1030:(6): 320–4.
1027:
1023:
982:
978:
947:
943:
912:
908:
868:
864:
854:
838:. Retrieved
825:
800:
796:
790:
776:
751:
747:
741:
725:
724:Peter Nuhn:
720:
675:
671:
661:
620:
616:
610:
586:(1): 39–45.
583:
579:
569:
544:
540:
534:
505:
498:
481:pancreatitis
474:
405:
404:
402:
383:
359:surface area
337:
332:
321:
317:
310:
303:
300:triglyceride
268:
264:
260:
259:
243:
225:
209:
208:
3134:Active site
3053:Nuclease S1
2824:Exonuclease
2718:Lecithinase
2547:Calcineurin
2485:Phosphatase
2391:Lipoprotein
2381:Endothelial
2175:PDB gallery
2046:Nitrogenous
1881:CPK-MB test
1821:Lipid panel
1756:Transferrin
1704:Bicarbonate
1699:Base excess
1608:blood tests
1533:dynamics".
522:medication)
390:trypsinogen
367:peristalsis
347:gallbladder
134:OPM protein
52:Identifiers
3406:Categories
3337:Isomerases
3311:Hydrolases
3178:Regulation
2366:Pancreatic
2303:Carboxylic
1973:Conjugated
1801:Metabolism
1741:Serum iron
1728:Iron tests
1649:Creatinine
1466:: 141–58.
527:References
495:Inhibitors
369:along the
339:Bile salts
285:hydrolyzes
161:structures
3216:EC number
2943:RNase III
2801:(includes
2742:Sulfatase
2655:Autotaxin
2519:Prostatic
2371:Lysosomal
2286:esterases
2282:Hydrolase
1963:Bilirubin
1913:Proteins
1891:Myoglobin
1689:Anion gap
1681:Acid-base
1629:Potassium
1572:IPR013818
541:Biochimie
292:molecules
95:PDOC00110
83:IPR013818
3412:EC 3.1.1
3240:Kinetics
3164:Cofactor
3127:Activity
3037:RNase T1
2799:Nuclease
2434:Cutinase
2076:Proteins
2053:Azotemia
1985:Pancreas
1771:Hormones
1736:Ferritin
1634:Chloride
1568:InterPro
1555:20136147
1525:19346257
1451:17269661
1421:39583651
1413:15316225
1326:14580194
1296:18353248
1267:28593258
1259:12667003
1184:16179352
1149:16385451
1105:19113953
1075:12369922
1046:11393534
1011:16431912
966:11278590
887:15863836
840:18 April
748:Genomics
516:Orlistat
510:See also
501:orlistat
489:autolyse
477:duodenum
465:PNLIPRP3
460:PNLIPRP2
455:PNLIPRP1
398:duodenum
394:colipase
363:monomers
355:emulsify
351:duodenum
277:pancreas
271:, is an
269:steapsin
250:2.3.1.43
241:(VLDL).
235:3.1.1.34
228:isozymes
219:) are a
178:RCSB PDB
78:InterPro
45:colipase
3396:Biology
3350:Ligases
3120:Enzymes
3010:RNase E
3005:RNase Z
3000:RNase A
2995:RNase P
2968:RNase H
2586:Phytase
2386:Hepatic
2361:Lingual
2357:Gastric
1993:Amylase
1718:Lactate
1713:content
1639:Calcium
1516:2682864
1480:9240923
1384:8406023
1355:9631512
1229:4305832
1221:8479519
1201:Bibcode
1140:1380225
1002:3695395
931:9822688
817:6207965
768:1783385
712:3458198
680:Bibcode
653:4281247
645:2304545
625:Bibcode
602:2917565
561:3147715
520:obesity
396:in the
388:(e.g.,
379:lacteal
217:3.1.1.3
90:PROSITE
71:PF00151
3382:Portal
3324:Lyases
2948:Drosha
2873:3.1.21
2841:RecBCD
2819:3.1.11
2439:PETase
2347:Lipase
1998:Lipase
1624:Sodium
1553:
1523:
1513:
1478:
1449:
1419:
1411:
1382:
1353:
1324:
1294:
1265:
1257:
1227:
1219:
1193:Nature
1182:
1147:
1137:
1103:
1073:
1044:
1009:
999:
964:
929:
885:
815:
766:
732:
710:
703:323291
700:
651:
643:
617:Nature
600:
559:
281:lipase
273:enzyme
221:family
193:PDBsum
167:
157:
115:SUPFAM
60:Lipase
57:Symbol
3276:Types
2957:Dicer
2912:;see
2738:3.1.6
2708:PDE4B
2704:PDE4A
2642:3.1.4
2611:IMPA3
2607:IMPA2
2603:IMPA1
2481:3.1.3
2449:3.1.2
2299:3.1.1
2123:Other
1417:S2CID
1263:S2CID
1225:S2CID
834:(PDF)
649:S2CID
450:PNLIP
445:PLA1A
406:PNLIP
343:liver
111:SCOPe
102:SCOP2
43:with
3368:list
3361:EC7
3355:list
3348:EC6
3342:list
3335:EC5
3329:list
3322:EC4
3316:list
3309:EC3
3303:list
3296:EC2
3290:list
3283:EC1
2875:-31:
2821:-16:
2807:and
2713:PDE5
2699:PDE3
2694:PDE2
2689:PDE1
2581:PTEN
2566:OCRL
2559:PP2A
2508:ALPP
2503:ALPL
2498:ALPI
2292:3.1)
2238:1lpb
2223:1n8s
2208:1gpl
2193:1lpa
1654:Urea
1566:and
1564:Pfam
1551:PMID
1521:PMID
1476:PMID
1447:PMID
1409:PMID
1380:PMID
1364:Gene
1351:PMID
1322:PMID
1292:PMID
1255:PMID
1217:PMID
1180:PMID
1145:PMID
1101:PMID
1071:PMID
1042:PMID
1007:PMID
962:PMID
927:PMID
883:PMID
842:2018
813:PMID
764:PMID
730:ISBN
708:PMID
641:PMID
598:PMID
557:PMID
436:LIPI
432:LIPH
427:LIPG
422:LIPC
410:gene
320:and
313:and
186:PDBj
182:PDBe
165:ECOD
155:Pfam
139:1lpa
107:1lpa
66:Pfam
3030:4/5
2084:LFT
1958:GGT
1946:AST
1941:ALT
1929:ALP
1831:HDL
1826:LDL
1543:doi
1511:PMC
1501:doi
1497:284
1468:doi
1439:doi
1401:doi
1372:doi
1368:131
1343:doi
1314:doi
1284:doi
1280:370
1247:doi
1209:doi
1197:362
1170:doi
1166:280
1135:PMC
1127:doi
1093:doi
1063:doi
1032:doi
997:PMC
987:doi
983:281
952:doi
948:276
917:doi
913:273
873:doi
805:doi
756:doi
698:PMC
688:doi
633:doi
621:343
588:doi
584:179
549:doi
483:or
440:LPL
289:fat
267:or
173:PDB
127:127
3408::
2988:2C
2983:2B
2978:2A
2959::
2950::
2740::
2620::
2609:,
2605:,
2521:)/
2483::
2451::
2420:A2
2415:A1
2301::
2290:EC
2284::
1709:CO
1570::
1549:.
1539:49
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1519:.
1509:.
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596:.
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545:70
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400:.
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322:2b
318:2a
247:EC
232:EC
214:EC
184:;
180:;
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109:/
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3370:)
3366:(
3357:)
3353:(
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2665:C
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