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Apical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between hemagglutinin proteins with different internalization signals. J. Cell Biol. 129,
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and therapeutic molecules that paved the way towards translational research (live recombinant vaccines and cancer virotherapy). Later, he became the director of vaccine research at Berna
Biotech (now
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Characteristics of the internalization signal in the Y543 influenza virus hemagglutinin suggest a model for recognition of internalization signals containing tyrosine. J. Biol. Chem. 269, 3928-3933
122:. His research was instrumental towards understanding the intracellular mechanisms of viral and membrane protein sorting in epithelial cells and the cell-surface assembly of several
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Tyrosine-based
Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells. J. Biol. Chem. 273, 26862-26869
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Mutations in the Middle of the
Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells. J. Cell Biol. 142, 51β57.
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Oncolytic measles virus in cutaneous T-cell lymphomas mount anti-tumor immune responses in vivo and target interferon resistant tumor cells. Blood, 106: 2287β2294.
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O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts. Current
Biology 9, 593β596.
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at Dallas, his research focused on the (i) basis of enveloped viruses assembly, and (ii) the mechanisms of membrane protein sorting and
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Effects of altering palmitylation sites on the biosynthesis and function of the
Influenza virus Hemagglutinin. J. Virol. 66, 7585β7588.
276:
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Measles virus matrix protein specifies apical virus release and glycoprotein sorting in epithelial cells. EMBO J. 19, 3576-3585
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Reverse genetics of measles virus and resulting multivalent recombinant vaccines. Curr. Topics
Microbiol. Immun. 329, 129β162.
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Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. J. Virol. 76, 5720β5728.
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Measles
Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence.J. Virol. 72, 1224β1234.
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Basis for selective incorporation of glycoproteins into influenza virus envelope. J. Virol. 67, 4831-4841
82:, known for his research in cell biology (membrane protein sorting and internalization) and virology (
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98:). He has held several leading positions at prominent universities and biotechnology centers.
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Use of viral vectors for the development of vaccines. Exp. Rev. Vaccines, 6 (2): 255β266.
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Gene
Transfer into Neurons from Hippocampal Slices. Mol. Cell. Neurosci. 17, 855-871
126:. He was appointed as a faculty member at the institute of molecular biology of the
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Chimeric
Measles Viruses with a Foreign Envelope. J. Virol. 72, 2150β2159.
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Hussein Naim received his Ph.D. degree in biochemistry from the
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130:. His research focused on the development of novel
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16:Lebanese-Swiss biochemist and molecular virologist
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112:University of Texas Southwestern Medical Center
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287:Academic staff of the University of Zurich
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282:University of Texas Medical Branch alumni
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272:Lebanese emigrants to Switzerland
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277:University of Bern alumni
262:Scientists from Beirut
128:University of Zurich
80:molecular virologist
74:is a Lebanese-Swiss
56:Molecular virologist
108:University of Bern
46:University of Bern
292:Swiss biochemists
267:Swiss virologists
102:Scientific career
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65:1989βpresent
23:Hussein Naim
124:RNA viruses
116:endocytosis
251:Categories
195:References
151:1241β1250.
76:biochemist
52:Occupation
96:Influenza
36:, Lebanon
136:Crucell
84:measles
34:Beirut
94:and
88:SARS
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29:Born
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92:HIV
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