690:
3108:
1062:
1012:
469:
323:
1266:
Bearfield JC, Keeling CI, Young S, Blomquist GJ, Tittiger C (April 2006). "Isolation, endocrine regulation and mRNA distribution of the 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMG-S) gene from the pine engraver, Ips pini (Coleoptera: Scolytidae)".
1354:
Steussy CN, Vartia AA, Burgner JW, Sutherlin A, Rodwell VW, Stauffacher CV (November 2005). "X-ray crystal structures of HMG-CoA synthase from
Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA".
1838:
1831:
1319:
Steussy CN, Robison AD, Tetrick AM, Knight JT, Rodwell VW, Stauffacher CV, Sutherlin AL (December 2006). "A structural limitation on enzyme activity: the case of HMG-CoA synthase".
722:
1824:
1444:
573:
427:
197:
48:
2644:
2639:
2445:
929:
925:
2208:
2203:
1038:
for the mitochondrial form of the enzyme has three sterol regulatory elements in the 5' flanking region. These elements are responsible for decreased
2627:
2034:
1980:
2634:
2398:
2148:
1437:
980:); in humans the cytosolic form has only 60.6% amino acid identity with the mitochondrial form of the enzyme. HMG-CoA is also found in other
1422:
3161:
3156:
2622:
1917:
1760:
1816:
2794:
2336:
2292:
2195:
1975:
1682:
1615:
221:
72:
2284:
2220:
1574:
2827:
2578:
2516:
1801:
1620:
1430:
2573:
2568:
1610:
1055:
209:
60:
2511:
2092:
1922:
1686:
202:
53:
2526:
2438:
2073:
1602:
1051:
682:. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of
628:
2983:
593:
447:
2691:
2671:
2585:
2408:
2115:
2063:
1996:
3098:
2612:
2506:
2501:
1703:
2774:
2548:
2403:
1957:
1534:
1120:
1116:
1112:
1108:
1529:
2784:
2617:
2491:
1524:
2968:
1080:, isoprenoid precursors are generally synthesised via an alternative, non-mevalonate pathway, however a number of
3171:
3084:
3071:
3058:
3045:
3032:
3019:
3006:
2732:
2708:
2659:
2543:
2496:
2471:
2431:
2068:
1783:
1744:
1726:
1558:
689:
2978:
2932:
2875:
2737:
2462:
1970:
1136:
1039:
886:
732:
663:
613:
113:
581:
435:
3176:
2880:
2779:
2686:
1579:
2747:
2742:
2607:
2039:
1645:
1593:
1501:
707:
214:
65:
2901:
2820:
2727:
2722:
2001:
1461:
683:
655:
2973:
577:
431:
2789:
2676:
2663:
2563:
2173:
2054:
1511:
1220:
933:
267:
130:
2937:
2521:
2044:
1721:
1675:
1539:
1516:
1047:
901:
752:
2870:
2359:
1875:
1867:
1292:
1100:
1015:
2245:
3166:
2752:
2481:
2370:
2300:
1965:
1946:
1496:
1411:
1372:
1336:
1284:
1248:
1189:
1104:
568:
422:
800:
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2916:
2911:
2885:
2813:
2717:
2681:
2378:
1898:
1851:
1457:
1401:
1364:
1328:
1276:
1238:
1228:
1179:
1169:
1132:
783:
262:
125:
1309:
Goldstein J.L., Brown M.S. (1990) Regulation of the mevalonate pathway. Nature 343, 425-430
560:
414:
118:
2963:
2947:
2860:
2757:
2458:
2423:
2130:
1087:
utilise a mevalonate pathway involving HMG-CoA synthase that is parallel to that found in
905:
795:
748:
671:
624:
291:
154:
271:
134:
1224:
3112:
3001:
2942:
2240:
2159:
1938:
1736:
1713:
1630:
1156:
Theisen MJ, Misra I, Saadat D, Campobasso N, Miziorko HM, Harrison DH (November 2004).
1406:
1389:
1243:
1208:
1184:
1158:"3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time""
1157:
3150:
2906:
2865:
1280:
1081:
1031:
977:
1296:
497:
351:
2855:
2140:
1465:
1027:
1004:
The cytosolic form is the starting point of the mevalonate pathway, which leads to
679:
651:
556:
410:
1011:
510:
364:
3142:
3128:
522:
376:
238:
89:
3079:
3014:
2850:
2696:
2454:
2256:
2168:
2083:
2016:
1927:
1909:
1859:
1487:
1065:
1005:
965:
874:
870:
779:
659:
301:
164:
3107:
2026:
1847:
1775:
1550:
1469:
1453:
981:
945:
921:
897:
882:
760:
736:
648:
644:
620:
245:
96:
3053:
3027:
2364:
2331:
2185:
2107:
1233:
1174:
1088:
973:
890:
863:
675:
1415:
1376:
1340:
1288:
1252:
1209:"An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl-CoA synthase"
1193:
468:
322:
3138:
3124:
2486:
2323:
2266:
2181:
1893:
1793:
1084:
1077:
969:
953:
866:
517:
371:
250:
101:
1061:
616:
2389:
2384:
2279:
2274:
2190:
2120:
1885:
1863:
985:
949:
909:
667:
534:
529:
388:
383:
1368:
1332:
3066:
2836:
2767:
2595:
2590:
2531:
2310:
2305:
2233:
2228:
1855:
1669:
1664:
1472:
993:
989:
878:
588:
442:
233:
84:
3040:
2649:
2536:
1696:
1691:
1659:
1654:
1649:
1060:
1010:
894:
740:
3134:
3120:
2553:
1043:
1035:
550:
504:
492:
404:
358:
346:
226:
179:
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
77:
2809:
2427:
1820:
1426:
473:
staphylococcus aureus 3-hydroxy-3-methylglutaryl-coa synthase
327:
staphylococcus aureus 3-hydroxy-3-methylglutaryl-coa synthase
688:
1390:"The biosynthesis of beta-hydroxy-beta-methylglutaric acid"
2805:
643:(HMG-CoA). This reaction comprises the second step in the
22:
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
786:
that convert acyl groups into alkyl groups on transfer.
711:
3133:
This article incorporates text from the public domain
3119:
This article incorporates text from the public domain
808:)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase
3096:
710:
2338:
2294:
2286:
2222:
2197:
462:
Hydroxymethylglutaryl-coenzyme A synthase C terminal
316:
Hydroxymethylglutaryl-coenzyme A synthase N terminal
2992:
2956:
2925:
2894:
2843:
2707:
2658:
2470:
2352:
2321:
2264:
2254:
2157:
2138:
2129:
2105:
2082:
2053:
2024:
2014:
1989:
1955:
1936:
1908:
1883:
1874:
1792:
1773:
1753:
1735:
1712:
1638:
1629:
1601:
1592:
1567:
1548:
1510:
1486:
1479:
619:is an enzyme which catalyzes the reaction in which
587:
567:
549:
544:
528:
516:
503:
491:
483:
478:
461:
441:
421:
403:
398:
382:
370:
357:
345:
337:
332:
315:
297:
287:
282:
261:
256:
244:
232:
220:
208:
196:
188:
183:
178:
160:
150:
145:
124:
112:
107:
95:
83:
71:
59:
47:
39:
31:
26:
21:
852:hydroxymethylglutaryl coenzyme A-condensing enzyme
716:
662:. This reaction is overactivated in patients with
1103:have been solved for this class of enzymes, with
908:(its second substrate) leads to the formation of
824:3-hydroxy-3-methylglutaryl coenzyme A synthetase
670:deficiency and the exhaustion of substrates for
1026:The mitochondrial form is responsible for the
832:3-hydroxy-3-methylglutaryl-coenzyme A synthase
820:3-hydroxy-3-methylglutaryl coenzyme A synthase
2821:
2439:
1832:
1438:
1050:is high in animals: the same is observed for
1008:and other sterolic and isoprenoid compounds.
836:beta-hydroxy-beta-methylglutaryl-CoA synthase
8:
2645:2-acylglycerol-3-phosphate O-acyltransferase
2640:1-acylglycerol-3-phosphate O-acyltransferase
654:pathway. HMG-CoA is an intermediate in both
2828:
2814:
2806:
2446:
2432:
2424:
2261:
2135:
2021:
1880:
1839:
1825:
1817:
1635:
1598:
1483:
1445:
1431:
1423:
930:valine, leucine and isoleucine degradation
926:synthesis and degradation of ketone bodies
541:
467:
395:
321:
279:
142:
1405:
1242:
1232:
1183:
1173:
1135:at the U.S. National Library of Medicine
848:hydroxymethylglutaryl coenzyme A synthase
816:3-hydroxy-3-methylglutaryl CoA synthetase
766:In humans, the protein is encoded by the
709:
2035:Farnesyl-diphosphate farnesyltransferase
3103:
1981:Isopentenyl-diphosphate delta isomerase
1148:
873:in the first step of the reaction: the
862:HMG-CoA synthase contains an important
828:3-hydroxy-3-methylglutaryl-CoA synthase
2635:Glycerol-3-phosphate O-acyltransferase
2399:Steroidogenic acute regulatory protein
1046:responsible for enzyme synthesis when
728:)-3-hydroxy-3-methylglutaryl-CoA + CoA
458:
312:
175:
18:
2628:Lecithin—cholesterol acyltransferase
778:This enzyme belongs to the family of
759:)-3-hydroxy-3-methylglutaryl-CoA and
7:
2623:Glyceronephosphate O-acyltransferase
1761:Hydroxyacyl-Coenzyme A dehydrogenase
802:. Other names in common use include
666:if left untreated, due to prolonged
2795:Sulfoacetaldehyde acetyltransferase
2487:Acetyl-Coenzyme A acetyltransferase
1976:Pyrophosphomevalonate decarboxylase
1894:Acetyl-Coenzyme A acetyltransferase
1616:Carnitine-acylcarnitine translocase
844:acetoacetyl coenzyme A transacetase
717:{\displaystyle \rightleftharpoons }
2711:: converted into alkyl on transfer
1575:Glycerol-3-phosphate dehydrogenase
607:hydroxymethylglutaryl-CoA synthase
14:
2517:Chloramphenicol acetyltransferase
1802:Long-chain-aldehyde dehydrogenase
1621:Carnitine palmitoyltransferase II
3106:
2569:Carnitine O-palmitoyltransferase
1611:Carnitine palmitoyltransferase I
1281:10.1111/j.1365-2583.2006.00627.x
1056:low density lipoprotein receptor
2512:Beta-galactoside transacetylase
2149:Cholesterol side-chain cleavage
2093:24-Dehydrocholesterol reductase
1923:3-hydroxybutyrate dehydrogenase
2527:Serotonin N-acetyl transferase
2474:: other than amino-acyl groups
2074:7-Dehydrocholesterol reductase
1052:3-hydroxy-3-methylglutaryl-CoA
920:This enzyme participates in 3
889:) to produce an acetyl-enzyme
1:
2692:Keratinocyte transglutaminase
2672:Gamma-glutamyl transpeptidase
2586:Serine C-palmitoyltransferase
2409:Reverse cholesterol transport
1997:Dimethylallyltranstransferase
1407:10.1016/S0021-9258(18)70822-3
545:Available protein structures:
399:Available protein structures:
2613:Aminolevulinic acid synthase
2507:Acetyl-CoA C-acyltransferase
2502:Dihydrolipoyl transacetylase
1704:Acetyl-CoA C-acyltransferase
1213:Proc. Natl. Acad. Sci. U.S.A
1207:Bahnson BJ (November 2004).
1162:Proc. Natl. Acad. Sci. U.S.A
3162:Genes on human chromosome 1
3157:Genes on human chromosome 5
2775:2-hydroxyglutarate synthase
2404:Cholesterol total synthesis
1535:3-Hydroxyacyl ACP dehydrase
944:HMG-CoA synthase occurs in
3193:
3132:
3118:
2785:2-isopropylmalate synthase
2618:Beta-ketoacyl-ACP synthase
2492:N-Acetylglutamate synthase
2116:Cholesterol 7α-hydroxylase
2064:Lanosterol 14α-demethylase
1525:Beta-ketoacyl-ACP synthase
968:, there are two different
2984:Michaelis–Menten kinetics
2733:Decylhomocitrate synthase
2544:Histone acetyltransferase
2497:Choline acetyltransferase
2069:Sterol-C5-desaturase-like
1784:Malonyl-CoA decarboxylase
1745:Propionyl-CoA carboxylase
1727:2,4 Dienoyl-CoA reductase
1559:Stearoyl-CoA desaturase-1
693:HMG-CoA synthase reaction
540:
466:
394:
320:
278:
141:
2876:Diffusion-limited enzyme
2738:2-methylcitrate synthase
1971:Phosphomevalonate kinase
1530:Î’-Ketoacyl ACP reductase
1269:Insect Molecular Biology
1137:Medical Subject Headings
798:of this enzyme class is
664:diabetes mellitus type 1
2780:3-propylmalate synthase
2687:Tissue transglutaminase
1234:10.1073/pnas.0407418101
1175:10.1073/pnas.0405809101
869:residue that acts as a
2748:3-ethylmalate synthase
2743:2-ethylmalate synthase
2608:Acyltransferase like 2
2040:Squalene monooxygenase
1646:Acyl CoA dehydrogenase
1502:Acetyl-CoA carboxylase
1068:
1018:
770:gene on chromosome 5.
718:
694:
2969:Eadie–Hofstee diagram
2902:Allosteric regulation
2728:Citrate (Re)-synthase
2723:Decylcitrate synthase
2664:Aminoacyltransferases
2564:palmitoyltransferases
2121:Sterol 27-hydroxylase
2002:Geranyl pyrophosphate
1462:fatty acid metabolism
1064:
1014:
782:, specifically those
719:
692:
684:diabetic ketoacidosis
656:cholesterol synthesis
2979:Lineweaver–Burk plot
2790:Homocitrate synthase
2677:Peptidyl transferase
2055:7-Dehydrocholesterol
1512:Fatty acid synthesis
940:Species distribution
934:butanoate metabolism
708:
704:O + acetoacetyl-CoA
2522:N-acetyltransferase
2045:Lanosterol synthase
1722:Enoyl CoA isomerase
1676:Enoyl-CoA hydratase
1540:Enoyl ACP reductase
1517:Fatty acid synthase
1225:2004PNAS..10116399B
1099:As of late 2007, 4
1048:dietary cholesterol
902:nucleophilic attack
735:of this enzyme are
2938:Enzyme superfamily
2871:Enzyme promiscuity
2482:acetyltransferases
2360:Steroid metabolism
1876:Mevalonate pathway
1868:steroid metabolism
1095:Structural studies
1069:
1019:
1016:Mevalonate pathway
922:metabolic pathways
751:, whereas its two
714:
695:
3094:
3093:
2803:
2802:
2753:ATP citrate lyase
2421:
2420:
2417:
2416:
2371:Steroid sulfatase
2348:
2347:
2101:
2100:
2010:
2009:
1966:Mevalonate kinase
1947:HMG-CoA reductase
1814:
1813:
1810:
1809:
1769:
1768:
1588:
1587:
1497:ATP citrate lyase
1388:RUDNEY H (1957).
1369:10.1021/bi051487x
1333:10.1021/bi061505q
1219:(47): 16399–400.
900:. The subsequent
812:(CoA-acetylating)
605:In biochemistry,
603:
602:
599:
598:
594:structure summary
457:
456:
453:
452:
448:structure summary
311:
310:
307:
306:
174:
173:
170:
169:
3184:
3172:Protein families
3111:
3110:
3102:
2974:Hanes–Woolf plot
2917:Enzyme activator
2912:Enzyme inhibitor
2886:Enzyme catalysis
2830:
2823:
2816:
2807:
2763:HMG-CoA synthase
2718:Citrate synthase
2682:Transglutaminase
2459:acyltransferases
2448:
2441:
2434:
2425:
2379:sulfotransferase
2340:
2296:
2288:
2262:
2224:
2199:
2136:
2022:
1901:(regulated step)
1899:HMG-CoA synthase
1881:
1852:lipid metabolism
1841:
1834:
1827:
1818:
1636:
1599:
1568:Triacyl glycerol
1484:
1458:lipid metabolism
1447:
1440:
1433:
1424:
1419:
1409:
1381:
1380:
1363:(43): 14256–67.
1351:
1345:
1344:
1327:(48): 14407–14.
1316:
1310:
1307:
1301:
1300:
1263:
1257:
1256:
1246:
1236:
1204:
1198:
1197:
1187:
1177:
1153:
1133:HMG-CoA+synthase
1107:accession codes
893:, releasing the
840:HMG-CoA synthase
784:acyltransferases
723:
721:
720:
715:
611:HMG-CoA synthase
542:
471:
459:
396:
325:
313:
280:
176:
143:
19:
16:Class of enzymes
3192:
3191:
3187:
3186:
3185:
3183:
3182:
3181:
3147:
3146:
3145:
3131:
3117:
3105:
3097:
3095:
3090:
3002:Oxidoreductases
2988:
2964:Enzyme kinetics
2952:
2948:List of enzymes
2921:
2890:
2861:Catalytic triad
2839:
2834:
2804:
2799:
2758:Malate synthase
2703:
2654:
2466:
2452:
2422:
2413:
2353:Other/ungrouped
2344:
2317:
2275:17α-Hydroxylase
2250:
2246:11β-Hydroxylase
2191:17α-Hydroxylase
2160:corticosteroids
2153:
2131:Steroidogenesis
2125:
2097:
2078:
2049:
2006:
1985:
1951:
1932:
1904:
1870:
1845:
1815:
1806:
1788:
1765:
1749:
1731:
1708:
1625:
1584:
1563:
1544:
1515:
1506:
1475:
1451:
1387:
1384:
1353:
1352:
1348:
1318:
1317:
1313:
1308:
1304:
1265:
1264:
1260:
1206:
1205:
1201:
1168:(47): 16442–7.
1155:
1154:
1150:
1146:
1129:
1097:
1074:
1024:
1002:
972:of the enzyme (
962:
942:
918:
916:Biological role
906:acetoacetyl-CoA
860:
796:systematic name
792:
776:
749:acetoacetyl-CoA
744:
729:
706:
705:
703:
697:
672:gluconeogenesis
625:acetoacetyl-CoA
623:condenses with
474:
328:
17:
12:
11:
5:
3190:
3188:
3180:
3179:
3177:Human proteins
3174:
3169:
3164:
3159:
3149:
3148:
3116:
3115:
3092:
3091:
3089:
3088:
3075:
3062:
3049:
3036:
3023:
3010:
2996:
2994:
2990:
2989:
2987:
2986:
2981:
2976:
2971:
2966:
2960:
2958:
2954:
2953:
2951:
2950:
2945:
2940:
2935:
2929:
2927:
2926:Classification
2923:
2922:
2920:
2919:
2914:
2909:
2904:
2898:
2896:
2892:
2891:
2889:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2847:
2845:
2841:
2840:
2835:
2833:
2832:
2825:
2818:
2810:
2801:
2800:
2798:
2797:
2792:
2787:
2782:
2777:
2772:
2771:
2770:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2714:
2712:
2705:
2704:
2702:
2701:
2700:
2699:
2694:
2689:
2679:
2674:
2668:
2666:
2656:
2655:
2653:
2652:
2647:
2642:
2637:
2631:
2630:
2625:
2620:
2615:
2610:
2601:
2600:
2599:
2598:
2593:
2583:
2582:
2581:
2576:
2559:
2558:
2557:
2556:
2551:
2541:
2540:
2539:
2534:
2529:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2477:
2475:
2468:
2467:
2453:
2451:
2450:
2443:
2436:
2428:
2419:
2418:
2415:
2414:
2412:
2411:
2406:
2401:
2395:
2394:
2393:
2392:
2387:
2375:
2374:
2373:
2356:
2354:
2350:
2349:
2346:
2345:
2343:
2342:
2334:
2328:
2326:
2319:
2318:
2316:
2315:
2314:
2313:
2308:
2298:
2290:
2282:
2277:
2271:
2269:
2259:
2252:
2251:
2249:
2248:
2243:
2241:21-Hydroxylase
2238:
2237:
2236:
2231:
2214:
2213:
2212:
2211:
2206:
2193:
2177:
2176:
2174:18-Hydroxylase
2164:
2162:
2155:
2154:
2152:
2151:
2145:
2143:
2133:
2127:
2126:
2124:
2123:
2118:
2112:
2110:
2103:
2102:
2099:
2098:
2096:
2095:
2089:
2087:
2080:
2079:
2077:
2076:
2071:
2066:
2060:
2058:
2051:
2050:
2048:
2047:
2042:
2037:
2031:
2029:
2019:
2012:
2011:
2008:
2007:
2005:
2004:
1999:
1993:
1991:
1987:
1986:
1984:
1983:
1978:
1973:
1968:
1962:
1960:
1953:
1952:
1950:
1949:
1943:
1941:
1939:Mevalonic acid
1934:
1933:
1931:
1930:
1925:
1920:
1914:
1912:
1906:
1905:
1903:
1902:
1896:
1890:
1888:
1878:
1872:
1871:
1846:
1844:
1843:
1836:
1829:
1821:
1812:
1811:
1808:
1807:
1805:
1804:
1798:
1796:
1790:
1789:
1787:
1786:
1780:
1778:
1771:
1770:
1767:
1766:
1764:
1763:
1757:
1755:
1751:
1750:
1748:
1747:
1741:
1739:
1733:
1732:
1730:
1729:
1724:
1718:
1716:
1710:
1709:
1707:
1706:
1700:
1699:
1694:
1689:
1679:
1678:
1673:
1667:
1662:
1657:
1652:
1642:
1640:
1633:
1631:Beta oxidation
1627:
1626:
1624:
1623:
1618:
1613:
1607:
1605:
1603:Acyl transport
1596:
1590:
1589:
1586:
1585:
1583:
1582:
1577:
1571:
1569:
1565:
1564:
1562:
1561:
1555:
1553:
1546:
1545:
1543:
1542:
1537:
1532:
1527:
1521:
1519:
1508:
1507:
1505:
1504:
1499:
1493:
1491:
1481:
1477:
1476:
1452:
1450:
1449:
1442:
1435:
1427:
1421:
1420:
1383:
1382:
1346:
1311:
1302:
1258:
1199:
1147:
1145:
1142:
1141:
1140:
1128:
1127:External links
1125:
1096:
1093:
1073:
1070:
1023:
1020:
1001:
998:
961:
958:
952:, and certain
941:
938:
917:
914:
859:
856:
791:
788:
775:
774:Classification
772:
742:
713:
701:
700:acetyl-CoA + H
699:
601:
600:
597:
596:
591:
585:
584:
571:
565:
564:
554:
547:
546:
538:
537:
532:
526:
525:
520:
514:
513:
508:
501:
500:
495:
489:
488:
487:HMG_CoA_synt_C
485:
481:
480:
476:
475:
472:
464:
463:
455:
454:
451:
450:
445:
439:
438:
425:
419:
418:
408:
401:
400:
392:
391:
386:
380:
379:
374:
368:
367:
362:
355:
354:
349:
343:
342:
341:HMG_CoA_synt_N
339:
335:
334:
330:
329:
326:
318:
317:
309:
308:
305:
304:
299:
295:
294:
289:
285:
284:
276:
275:
265:
259:
258:
254:
253:
248:
242:
241:
236:
230:
229:
224:
218:
217:
212:
206:
205:
200:
194:
193:
190:
186:
185:
181:
180:
172:
171:
168:
167:
162:
158:
157:
152:
148:
147:
139:
138:
128:
122:
121:
116:
110:
109:
105:
104:
99:
93:
92:
87:
81:
80:
75:
69:
68:
63:
57:
56:
51:
45:
44:
41:
37:
36:
33:
29:
28:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3189:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3154:
3152:
3144:
3140:
3136:
3130:
3126:
3122:
3114:
3109:
3104:
3100:
3086:
3082:
3081:
3076:
3073:
3069:
3068:
3063:
3060:
3056:
3055:
3050:
3047:
3043:
3042:
3037:
3034:
3030:
3029:
3024:
3021:
3017:
3016:
3011:
3008:
3004:
3003:
2998:
2997:
2995:
2991:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2961:
2959:
2955:
2949:
2946:
2944:
2943:Enzyme family
2941:
2939:
2936:
2934:
2931:
2930:
2928:
2924:
2918:
2915:
2913:
2910:
2908:
2907:Cooperativity
2905:
2903:
2900:
2899:
2897:
2893:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2866:Oxyanion hole
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2848:
2846:
2842:
2838:
2831:
2826:
2824:
2819:
2817:
2812:
2811:
2808:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2769:
2766:
2765:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2715:
2713:
2710:
2706:
2698:
2695:
2693:
2690:
2688:
2685:
2684:
2683:
2680:
2678:
2675:
2673:
2670:
2669:
2667:
2665:
2661:
2657:
2651:
2648:
2646:
2643:
2641:
2638:
2636:
2633:
2632:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2603:
2602:
2597:
2594:
2592:
2589:
2588:
2587:
2584:
2580:
2577:
2575:
2572:
2571:
2570:
2567:
2565:
2561:
2560:
2555:
2552:
2550:
2547:
2546:
2545:
2542:
2538:
2535:
2533:
2530:
2528:
2525:
2524:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2479:
2478:
2476:
2473:
2469:
2464:
2460:
2456:
2449:
2444:
2442:
2437:
2435:
2430:
2429:
2426:
2410:
2407:
2405:
2402:
2400:
2397:
2396:
2391:
2388:
2386:
2383:
2382:
2381:
2380:
2376:
2372:
2369:
2368:
2367:
2366:
2361:
2358:
2357:
2355:
2351:
2341:
2335:
2333:
2330:
2329:
2327:
2325:
2320:
2312:
2309:
2307:
2304:
2303:
2302:
2299:
2297:
2291:
2289:
2283:
2281:
2278:
2276:
2273:
2272:
2270:
2268:
2263:
2260:
2258:
2253:
2247:
2244:
2242:
2239:
2235:
2232:
2230:
2227:
2226:
2225:
2219:
2216:
2215:
2210:
2207:
2205:
2202:
2201:
2200:
2194:
2192:
2189:
2187:
2183:
2179:
2178:
2175:
2172:
2170:
2166:
2165:
2163:
2161:
2156:
2150:
2147:
2146:
2144:
2142:
2137:
2134:
2132:
2128:
2122:
2119:
2117:
2114:
2113:
2111:
2109:
2104:
2094:
2091:
2090:
2088:
2085:
2081:
2075:
2072:
2070:
2067:
2065:
2062:
2061:
2059:
2056:
2052:
2046:
2043:
2041:
2038:
2036:
2033:
2032:
2030:
2028:
2023:
2020:
2018:
2013:
2003:
2000:
1998:
1995:
1994:
1992:
1988:
1982:
1979:
1977:
1974:
1972:
1969:
1967:
1964:
1963:
1961:
1959:
1954:
1948:
1945:
1944:
1942:
1940:
1935:
1929:
1926:
1924:
1921:
1919:
1918:HMG-CoA lyase
1916:
1915:
1913:
1911:
1907:
1900:
1897:
1895:
1892:
1891:
1889:
1887:
1882:
1879:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1842:
1837:
1835:
1830:
1828:
1823:
1822:
1819:
1803:
1800:
1799:
1797:
1795:
1791:
1785:
1782:
1781:
1779:
1777:
1772:
1762:
1759:
1758:
1756:
1752:
1746:
1743:
1742:
1740:
1738:
1734:
1728:
1725:
1723:
1720:
1719:
1717:
1715:
1711:
1705:
1702:
1701:
1698:
1695:
1693:
1690:
1688:
1684:
1681:
1680:
1677:
1674:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1651:
1647:
1644:
1643:
1641:
1637:
1634:
1632:
1628:
1622:
1619:
1617:
1614:
1612:
1609:
1608:
1606:
1604:
1600:
1597:
1595:
1591:
1581:
1578:
1576:
1573:
1572:
1570:
1566:
1560:
1557:
1556:
1554:
1552:
1547:
1541:
1538:
1536:
1533:
1531:
1528:
1526:
1523:
1522:
1520:
1518:
1513:
1509:
1503:
1500:
1498:
1495:
1494:
1492:
1489:
1485:
1482:
1478:
1474:
1471:
1467:
1463:
1459:
1455:
1448:
1443:
1441:
1436:
1434:
1429:
1428:
1425:
1417:
1413:
1408:
1403:
1400:(1): 363–77.
1399:
1395:
1394:J. Biol. Chem
1391:
1386:
1385:
1378:
1374:
1370:
1366:
1362:
1358:
1350:
1347:
1342:
1338:
1334:
1330:
1326:
1322:
1315:
1312:
1306:
1303:
1298:
1294:
1290:
1286:
1282:
1278:
1275:(2): 187–95.
1274:
1270:
1262:
1259:
1254:
1250:
1245:
1240:
1235:
1230:
1226:
1222:
1218:
1214:
1210:
1203:
1200:
1195:
1191:
1186:
1181:
1176:
1171:
1167:
1163:
1159:
1152:
1149:
1143:
1138:
1134:
1131:
1130:
1126:
1124:
1122:
1118:
1114:
1110:
1106:
1102:
1094:
1092:
1090:
1086:
1083:
1082:Gram-positive
1079:
1071:
1067:
1063:
1059:
1057:
1053:
1049:
1045:
1041:
1040:transcription
1037:
1033:
1032:ketone bodies
1029:
1022:Mitochondrial
1021:
1017:
1013:
1009:
1007:
999:
997:
995:
991:
987:
983:
979:
978:mitochondrial
975:
971:
967:
959:
957:
955:
951:
947:
939:
937:
935:
931:
927:
923:
915:
913:
911:
907:
903:
899:
896:
892:
888:
884:
880:
876:
872:
868:
865:
857:
855:
853:
849:
845:
841:
837:
833:
829:
825:
821:
817:
813:
809:
805:
801:
797:
789:
787:
785:
781:
773:
771:
769:
764:
762:
758:
754:
750:
746:
738:
734:
727:
698:
691:
687:
685:
681:
677:
673:
669:
665:
661:
657:
653:
650:
646:
642:
640:
636:
632:
626:
622:
618:
615:
612:
608:
595:
592:
590:
586:
583:
579:
575:
572:
570:
566:
562:
558:
555:
552:
548:
543:
539:
536:
533:
531:
527:
524:
521:
519:
515:
512:
509:
506:
502:
499:
496:
494:
490:
486:
482:
477:
470:
465:
460:
449:
446:
444:
440:
437:
433:
429:
426:
424:
420:
416:
412:
409:
406:
402:
397:
393:
390:
387:
385:
381:
378:
375:
373:
369:
366:
363:
360:
356:
353:
350:
348:
344:
340:
336:
331:
324:
319:
314:
303:
300:
296:
293:
290:
286:
281:
277:
274:
273:
269:
266:
264:
260:
255:
252:
249:
247:
243:
240:
237:
235:
231:
228:
225:
223:
219:
216:
213:
211:
207:
204:
201:
199:
195:
191:
187:
182:
177:
166:
163:
159:
156:
153:
149:
144:
140:
137:
136:
132:
129:
127:
123:
120:
117:
115:
111:
106:
103:
100:
98:
94:
91:
88:
86:
82:
79:
76:
74:
70:
67:
64:
62:
58:
55:
52:
50:
46:
42:
38:
34:
30:
25:
20:
3080:Translocases
3077:
3064:
3051:
3038:
3025:
3015:Transferases
3012:
2999:
2856:Binding site
2762:
2604:
2562:
2480:
2455:Transferases
2377:
2363:
2301:5α-Reductase
2257:sex hormones
2217:
2180:
2167:
2141:pregnenolone
1466:triglyceride
1397:
1393:
1360:
1357:Biochemistry
1356:
1349:
1324:
1321:Biochemistry
1320:
1314:
1305:
1272:
1268:
1261:
1216:
1212:
1202:
1165:
1161:
1151:
1098:
1075:
1028:biosynthesis
1025:
1003:
963:
943:
919:
861:
851:
847:
843:
839:
835:
831:
827:
823:
819:
815:
811:
807:
803:
799:
793:
790:Nomenclature
780:transferases
777:
767:
765:
756:
730:
725:
696:
680:oxaloacetate
652:biosynthesis
638:
634:
630:
610:
606:
604:
270:
133:
40:Alt. symbols
2851:Active site
2697:Factor XIII
2280:17,20-Lyase
2169:aldosterone
2084:Desmosterol
2017:cholesterol
1928:Thiophorase
1910:Ketogenesis
1860:cholesterol
1714:Unsaturated
1594:Degradation
1551:desaturases
1549:Fatty acid
1488:Malonyl-CoA
1066:Ketogenesis
1006:cholesterol
966:vertebrates
885:(its first
875:acetylation
871:nucleophile
660:ketogenesis
647:-dependent
641:lutaryl-CoA
479:Identifiers
333:Identifiers
292:Swiss-model
184:Identifiers
155:Swiss-model
27:Identifiers
3151:Categories
3054:Isomerases
3028:Hydrolases
2895:Regulation
2108:Bile acids
2027:lanosterol
1862:synthesis
1848:Metabolism
1776:acetyl-CoA
1580:Thiokinase
1470:fatty acid
1454:Metabolism
1144:References
1101:structures
1089:eukaryotes
982:eukaryotes
960:Eukaryotes
946:eukaryotes
898:coenzyme A
883:acetyl-CoA
737:acetyl-CoA
733:substrates
678:, notably
649:isoprenoid
645:mevalonate
621:acetyl-CoA
557:structures
411:structures
288:Structures
283:Search for
257:Other data
151:Structures
146:Search for
108:Other data
3143:IPR013528
3129:IPR013746
2933:EC number
2365:sulfatase
2332:Aromatase
2324:estrogens
2267:androgens
2186:cortisone
1794:Aldehydes
1737:Odd chain
1490:synthesis
1480:Synthesis
1085:pathogens
1000:Cytosolic
974:cytosolic
891:thioester
887:substrate
864:catalytic
858:Mechanism
712:⇌
676:TCA cycle
633:ydroxy-3-
535:PDOC00942
523:IPR013746
389:PDOC00942
377:IPR013528
239:NM_005518
198:NCBI gene
114:EC number
90:NM_002130
49:NCBI gene
3167:EC 2.3.3
3139:InterPro
3125:InterPro
2957:Kinetics
2881:Cofactor
2844:Activity
2549:P300/CBP
2182:cortisol
1990:Geranyl-
1416:13449080
1377:16245942
1341:17128980
1297:46317830
1289:16640729
1253:15546978
1194:15498869
1078:bacteria
1072:Bacteria
1054:and the
984:such as
970:isozymes
954:bacteria
867:cysteine
753:products
674:and the
627:to form
617:2.3.3.10
574:RCSB PDB
518:InterPro
428:RCSB PDB
372:InterPro
302:InterPro
165:InterPro
119:2.3.3.10
3113:Biology
3067:Ligases
2837:Enzymes
2390:SULT2A1
2385:SULT1A1
1886:HMG-CoA
1864:enzymes
1856:ketones
1639:General
1473:enzymes
1221:Bibcode
1044:message
1042:of the
986:insects
950:archaea
910:HMG-CoA
895:reduced
877:of the
668:insulin
530:PROSITE
498:PF08540
384:PROSITE
352:PF01154
298:Domains
272:p13-p12
246:UniProt
161:Domains
135:p14-p13
97:UniProt
3099:Portal
3041:Lyases
2768:HMGCS2
2605:other:
2596:SPTLC2
2591:SPTLC1
2532:HGSNAT
1670:ACADSB
1665:ACADVL
1414:
1375:
1339:
1295:
1287:
1251:
1244:534547
1241:
1192:
1185:534525
1182:
1139:(MeSH)
1119:, and
1034:. The
992:, and
990:plants
932:, and
879:enzyme
850:, and
768:HMGCS1
747:, and
731:The 3
589:PDBsum
563:
553:
511:CL0046
484:Symbol
443:PDBsum
417:
407:
365:CL0046
338:Symbol
268:Chr. 1
251:P54868
234:RefSeq
227:600234
192:HMGCS2
189:Symbol
131:Chr. 5
102:Q01581
85:RefSeq
78:142940
35:HMGCS1
32:Symbol
2993:Types
2709:2.3.3
2660:2.3.2
2650:ABHD5
2537:ARD1A
2472:2.3.1
2218:both:
1958:DMAPP
1754:Other
1697:HADHB
1692:HADHA
1660:ACADS
1655:ACADM
1650:ACADL
1293:S2CID
994:fungi
755:are (
637:ethyl
263:Locus
126:Locus
43:HMGCS
3137:and
3135:Pfam
3123:and
3121:Pfam
3085:list
3078:EC7
3072:list
3065:EC6
3059:list
3052:EC5
3046:list
3039:EC4
3033:list
3026:EC3
3020:list
3013:EC2
3007:list
3000:EC1
2579:CPT2
2574:CPT1
2554:NAT2
2465:2.3)
2337:17β-
2293:17β-
2196:11β-
2086:path
2057:path
1687:HADH
1468:and
1412:PMID
1373:PMID
1337:PMID
1285:PMID
1249:PMID
1190:PMID
1121:2P8U
1117:1XPM
1113:1XPL
1109:1XPK
1036:gene
976:and
794:The
658:and
582:PDBj
578:PDBe
561:ECOD
551:Pfam
507:clan
505:Pfam
493:Pfam
436:PDBj
432:PDBe
415:ECOD
405:Pfam
361:clan
359:Pfam
347:Pfam
222:OMIM
215:5008
210:HGNC
203:3158
73:OMIM
66:5007
61:HGNC
54:3157
2339:HSD
2322:To
2295:HSD
2287:HSD
2285:3β-
2265:To
2255:To
2223:HSD
2221:3β-
2198:HSD
2158:To
2139:To
2106:To
2025:To
2015:To
1956:To
1937:To
1884:To
1774:To
1683:MTP
1402:doi
1398:227
1365:doi
1329:doi
1277:doi
1239:PMC
1229:doi
1217:101
1180:PMC
1170:doi
1166:101
1105:PDB
1076:In
1030:of
964:In
904:on
881:by
761:CoA
609:or
569:PDB
423:PDB
3153::
3141::
3127::
2662::
2463:EC
2457::
2362::
1854:–
1850::
1685::
1464:,
1460:/
1456::
1410:.
1396:.
1392:.
1371:.
1361:44
1359:.
1335:.
1325:45
1323:.
1291:.
1283:.
1273:15
1271:.
1247:.
1237:.
1227:.
1215:.
1211:.
1188:.
1178:.
1164:.
1160:.
1123:.
1115:,
1111:,
1091:.
1058:.
996:.
988:,
956:.
948:,
936:.
928:,
924::
912:.
854:.
846:,
842:,
838:,
834:,
830:,
826:,
822:,
818:,
814:,
810:,
763:.
739:,
686:.
629:3-
614:EC
580:;
576:;
559:/
434:;
430:;
413:/
3101::
3087:)
3083:(
3074:)
3070:(
3061:)
3057:(
3048:)
3044:(
3035:)
3031:(
3022:)
3018:(
3009:)
3005:(
2829:e
2822:t
2815:v
2566::
2484::
2461:(
2447:e
2440:t
2433:v
2311:2
2306:1
2234:2
2229:1
2209:2
2204:1
2188::
2184:/
2171::
1866:/
1858:/
1840:e
1833:t
1826:v
1672:)
1648:(
1514:/
1446:e
1439:t
1432:v
1418:.
1404::
1379:.
1367::
1343:.
1331::
1299:.
1279::
1255:.
1231::
1223::
1196:.
1172::
806:S
804:(
757:S
745:O
743:2
741:H
726:S
724:(
702:2
639:g
635:m
631:h
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.