252:
229:
126:
151:
258:
157:
3214:
972:
1257:
1920:
2522:
2829:
2546:
2502:
2017:
1590:
Eckhart L, Schmidt M, Mildner M, et al. (2008). "Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid".
1789:
Alemán G, OrtĂz V, Langley E, et al. (2005). "Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells".
1441:
Schwede TF, RĂ©tey J, Schulz GE (Apr 27, 1999). "Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile".
265:
164:
1137:
2107:
1760:
Taylor RG, GarcĂa-Heras J, Sadler SJ, et al. (1991). "Localization of histidase to human chromosome region 12q22→q24.1 and mouse chromosome region 10C2→D1".
1723:
Kawai Y, Moriyama A, Asai K, et al. (2005). "Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene".
1156:
2551:
1913:
2541:
2497:
2347:
2012:
1838:
687:
87:
668:
2822:
2603:
2112:
2343:
1906:
3234:
2064:
1371:
1353:
2204:
2027:
1889:
1406:
Suchi M, Sano H, Mizuno H, Wada Y (September 1995). "Molecular cloning and structural characterization of the human histidase gene (HAL)".
2815:
251:
2866:
2717:
2314:
2037:
1510:
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine".
2517:
2007:
903:
910:
228:
2933:
2512:
2429:
2338:
2042:
1392:
1242:
1149:
2184:
1340:
1319:
1621:"A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions"
2576:
2057:
2052:
1076:
150:
125:
3089:
1336:
1100:
2727:
2722:
2439:
2102:
1315:
67:
2876:
2665:
2616:
2083:
1290:
1261:
1229:
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative
3204:
2371:
2087:
1988:
1983:
1898:
264:
163:
3074:
3190:
3177:
3164:
3151:
3138:
3125:
3112:
2886:
2852:
2712:
2707:
2660:
2621:
2266:
3084:
257:
156:
3038:
2981:
2843:
2670:
2247:
1882:
1829:
1177:
1094:
987:
732:
75:
1549:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
2986:
2895:
2401:
2376:
2286:
2047:
1250:
1081:
713:
2900:
2788:
2581:
2434:
3007:
2926:
2783:
2147:
1161:
139:
3079:
1069:
3239:
2454:
2228:
1961:
1951:
1937:
1675:
1004:
1481:
Suchi M, Harada N, Wada Y, Takagi Y (1993). "Molecular cloning of a cDNA encoding human histidase".
54:
3043:
2598:
2594:
2507:
2392:
2022:
1875:
1825:
999:
861:
857:
806:
802:
1097:
2976:
2871:
2640:
2189:
2067:– this diagram does not include the pathway for β-leucine synthesis via leucine 2,3-aminomutase)
1933:
1748:
1693:
1535:
1021:
99:
1664:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
886:
865:
831:
810:
3244:
2032:
1806:
1777:
1740:
1711:
1650:
1607:
1578:
1527:
1498:
1458:
1423:
1278:
1088:
47:
3022:
3017:
2991:
2919:
2757:
1798:
1769:
1732:
1701:
1683:
1640:
1632:
1599:
1568:
1560:
1519:
1490:
1450:
1415:
344:
275:
219:
174:
3069:
3053:
2966:
2333:
2209:
2092:
1057:
319:
95:
1679:
1033:
3218:
3107:
3048:
1859:
1645:
1620:
1253:
which is formed autocatalytically by cyclization of the protein backbone of the enzyme.
1132:
992:
1706:
1663:
1573:
1548:
1112:
602:
597:
592:
587:
571:
566:
550:
545:
540:
3228:
3012:
2971:
2694:
2474:
2122:
1842:
1494:
1211:
1107:
522:
1752:
1539:
2961:
2779:
2651:
2479:
2097:
1603:
1274:
337:
116:
2807:
79:
103:
3185:
3120:
2956:
2459:
2425:
1376:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1358:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1230:
1116:
3213:
1802:
420:
2766:
2742:
2611:
2589:
2571:
2561:
2532:
2381:
2074:
1965:
1929:
1736:
236:
133:
83:
3159:
3133:
2770:
2631:
2450:
2446:
2421:
2309:
2295:
2281:
2257:
1636:
1203:
632:
480:
358:
303:
290:
202:
189:
91:
1810:
1744:
1715:
1688:
1654:
1611:
1582:
1531:
1462:
1419:
1781:
1502:
1427:
950:
945:
17:
2734:
2698:
2685:
2417:
2362:
2238:
2200:
2157:
2126:
934:
777:
758:
1523:
535:
2738:
2324:
2219:
2196:
2171:
2162:
1998:
1697:
1564:
1207:
1180:
1064:
1045:
744:
699:
1773:
1454:
3172:
2942:
2488:
2175:
1974:
1941:
1192:
1144:
1040:
1028:
1016:
918:
654:
1260:
Proposed autocatalytic formation of MIO cofactor in another enzyme,
3146:
2839:
2352:
1855:
1255:
1264:, from the tripeptide Ala-Ser-Gly by two water elimination steps.
617:
613:
1199:
1052:
71:
2915:
2811:
1902:
971:
1256:
58:, HIS, HSTD, histidine ammonia-lyase, Histidine ammonia-lyase
1662:
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
2911:
1619:
Welsh MM, Karagas MR, Applebaum KM, et al. (2008).
1273:
Mutations in the gene for histidase are associated with
976:
Histidine ammonia-lyase homotetramer, Pseudomonas putida
327:
1863:
1547:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
598:
histidine catabolic process to glutamate and formamide
3202:
492:
2547:
Branched-chain alpha-keto acid dehydrogenase complex
2503:
Branched-chain alpha-keto acid dehydrogenase complex
2018:
Branched-chain alpha-keto acid dehydrogenase complex
593:
histidine catabolic process to glutamate and formate
3098:
3062:
3031:
3000:
2949:
2885:
2851:
2765:
2755:
2693:
2683:
2649:
2630:
2560:
2531:
2487:
2472:
2410:
2390:
2361:
2323:
2294:
2279:
2256:
2237:
2218:
2170:
2155:
2146:
2121:
2073:
1997:
1973:
1960:
1155:
1143:
1131:
1126:
1106:
1087:
1075:
1063:
1051:
1039:
1027:
1015:
1010:
998:
986:
981:
964:
879:
850:
824:
795:
1332:
1330:
1328:
1311:
1309:
1307:
274:
173:
2108:Aminocarboxymuconate-semialdehyde decarboxylase
1293:, another enzyme that contains the MIO cofactor
1337:GRCm38: Ensembl release 89: ENSMUSG00000020017
2927:
2823:
1914:
1883:
1241:-urocanic acid. The reaction is catalyzed by
8:
1219:-histidine ammonia-lyase (urocanate-forming)
2552:3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1316:GRCh38: Ensembl release 89: ENSG00000084110
2934:
2920:
2912:
2830:
2816:
2808:
2762:
2690:
2542:Branched-chain amino acid aminotransferase
2498:Branched-chain amino acid aminotransferase
2484:
2291:
2167:
2152:
2013:Branched-chain amino acid aminotransferase
1970:
1921:
1907:
1899:
1890:
1876:
1839:United States National Library of Medicine
1123:
628:
518:
315:
214:
111:
2523:Methylmalonate semialdehyde dehydrogenase
1828:at the U.S. National Library of Medicine
1705:
1687:
1644:
1572:
2113:Aminomuconate-semialdehyde dehydrogenase
1837:This article incorporates text from the
1387:
1385:
3209:
2344:1-Pyrroline-5-carboxylate dehydrogenase
1303:
2604:Betaine-homocysteine methyltransferase
1393:"Entrez Gene: histidine ammonia-lyase"
961:
28:
2065:Template:Leucine metabolism in humans
279:
240:
235:
178:
137:
132:
7:
2205:Guanidinoacetate N-methyltransferase
1851:
1849:
2867:Formiminotransferase cyclodeaminase
2718:4-Hydroxyphenylpyruvate dioxygenase
2315:Formiminotransferase cyclodeaminase
2038:Isovaleryl coenzyme A dehydrogenase
2518:3-hydroxyisobutyrate dehydrogenase
2008:3-Hydroxybutyryl-CoA dehydrogenase
876:
847:
821:
792:
768:
749:
723:
704:
678:
659:
497:
415:
353:
332:
25:
2513:3-hydroxyisobutyryl-CoA hydrolase
2430:Gamma-glutamylcysteine synthetase
2339:Pyrroline-5-carboxylate reductase
1791:Am. J. Physiol. Endocrinol. Metab
1195:that in humans is encoded by the
3212:
970:
551:histidine ammonia-lyase activity
263:
256:
250:
227:
162:
155:
149:
124:
2185:Serine hydroxymethyltransferase
2599:Homocysteine methyltransferase
2577:Methionine adenosyltransferase
2058:Methylglutaconyl-CoA hydratase
2053:Methylcrotonyl-CoA carboxylase
1604:10.1016/j.jdermsci.2007.12.009
481:More reference expression data
1:
2728:Fumarylacetoacetate hydrolase
2723:Homogentisate 1,2-dioxygenase
2440:Gamma-glutamyl transpeptidase
2103:3-hydroxyanthranilate oxidase
2043:α-Ketoisocaproate dioxygenase
248:
147:
3235:Genes on human chromosome 12
1862:. You can help Knowledge by
1668:Proc. Natl. Acad. Sci. U.S.A
1495:10.1016/0167-4781(93)90157-9
2877:Phenylalanine ammonia-lyase
2666:Methylmalonyl CoA epimerase
2617:Cystathionine beta synthase
2084:Indoleamine 2,3-dioxygenase
1291:Phenylalanine ammonia-lyase
1262:phenylalanine ammonia-lyase
1243:3,5-dihydro-5-methyldiene-4
603:histidine catabolic process
588:histidine metabolic process
3261:
2590:regeneration of methionine
2572:generation of homocysteine
2372:Ornithine aminotransferase
2088:Tryptophan 2,3-dioxygenase
1989:Glutaryl-CoA dehydrogenase
1984:Saccharopine dehydrogenase
1848:
1803:10.1152/ajpendo.00584.2004
3090:Michaelis–Menten kinetics
2713:Tyrosine aminotransferase
2708:Phenylalanine hydroxylase
2661:Propionyl-CoA carboxylase
2622:Cystathionine gamma-lyase
2267:L-threonine dehydrogenase
1948:
1737:10.1007/s00439-004-1232-5
1372:"Mouse PubMed Reference:"
1354:"Human PubMed Reference:"
1214:. Its systematic name is
1122:
969:
949:
944:
940:
933:
917:
898:
883:
854:
843:
828:
799:
788:
775:
771:
756:
752:
743:
730:
726:
711:
707:
698:
685:
681:
666:
662:
653:
638:
631:
627:
611:
521:
517:
505:
500:
491:
478:
427:
418:
365:
356:
326:
318:
314:
297:
284:
247:
226:
217:
213:
196:
183:
146:
123:
114:
110:
65:
62:
52:
45:
40:
36:
31:
2982:Diffusion-limited enzyme
2671:Methylmalonyl-CoA mutase
2248:D-cysteine desulfhydrase
1830:Medical Subject Headings
1249:(MIO), an electrophilic
911:Chr 10: 93.32 – 93.36 Mb
2896:Argininosuccinate lyase
2862:Histidine ammonia-lyase
2402:Glutamate dehydrogenase
2377:Ornithine decarboxylase
2305:Histidine ammonia-lyase
2048:Leucine 2,3-aminomutase
1826:Histidine+Ammonia-Lyase
1174:Histidine ammonia-lyase
965:histidine ammonia-lyase
2901:Adenylosuccinate lyase
2789:Aspartate transaminase
2612:conversion to cysteine
2582:Adenosylhomocysteinase
2435:Glutathione synthetase
1689:10.1073/pnas.242603899
1483:Biochim. Biophys. Acta
1420:10.1006/geno.1995.1219
1265:
546:ammonia-lyase activity
451:lumbar spinal ganglion
281:10 C2|10 48.49 cM
3075:Eadie–Hofstee diagram
3008:Allosteric regulation
2784:Asparagine synthetase
1952:Essential amino acids
1762:Cytogenet. Cell Genet
1637:10.1093/carcin/bgn160
1259:
904:Chr 12: 95.97 – 96 Mb
242:Chromosome 10 (mouse)
140:Chromosome 12 (human)
3085:Lineweaver–Burk plot
2455:Glutamine synthetase
2229:Alanine transaminase
435:skin of external ear
2595:Methionine synthase
2508:Enoyl-CoA hydratase
2393:alpha-ketoglutarate
2310:Urocanate hydratase
2023:Enoyl-CoA hydratase
1680:2002PNAS...9916899M
1524:10.1038/gene.2010.1
369:right lobe of liver
3044:Enzyme superfamily
2977:Enzyme promiscuity
2872:Serine dehydratase
2641:Threonine aldolase
2190:Serine dehydratase
1934:Protein metabolism
1841:, which is in the
1565:10.1101/gr.2596504
1266:
733:ENSMUSG00000020017
581:Biological process
560:Cellular component
536:catalytic activity
529:Molecular function
439:left lobe of liver
3200:
3199:
2909:
2908:
2805:
2804:
2801:
2800:
2797:
2796:
2751:
2750:
2679:
2678:
2468:
2467:
2275:
2274:
2142:
2141:
2033:HMG-CoA reductase
1871:
1870:
1774:10.1159/000133082
1674:(26): 16899–903.
1455:10.1021/bi982929q
1449:(17): 5355–5361.
1279:urocanic aciduria
1236:
1218:
1171:
1170:
1167:
1166:
1070:metabolic pathway
960:
959:
956:
955:
929:
928:
894:
893:
873:
872:
839:
838:
818:
817:
784:
783:
765:
764:
739:
738:
720:
719:
694:
693:
675:
674:
623:
622:
513:
512:
509:
508:
487:
486:
474:
473:
412:
411:
310:
309:
209:
208:
16:(Redirected from
3252:
3217:
3216:
3208:
3080:Hanes–Woolf plot
3023:Enzyme activator
3018:Enzyme inhibitor
2992:Enzyme catalysis
2936:
2929:
2922:
2913:
2889:: amidine-lyases
2855:: ammonia-lyases
2838:Carbon–nitrogen
2832:
2825:
2818:
2809:
2763:
2691:
2485:
2292:
2168:
2153:
1971:
1923:
1916:
1909:
1900:
1892:
1885:
1878:
1850:
1814:
1785:
1756:
1719:
1709:
1691:
1658:
1648:
1615:
1592:J. Dermatol. Sci
1586:
1576:
1543:
1506:
1467:
1466:
1438:
1432:
1431:
1403:
1397:
1396:
1389:
1380:
1379:
1368:
1362:
1361:
1350:
1344:
1334:
1323:
1313:
1234:
1216:
1124:
974:
962:
942:
941:
913:
906:
889:
877:
868:
848:
844:RefSeq (protein)
834:
822:
813:
793:
769:
750:
724:
705:
679:
660:
629:
519:
498:
483:
423:
421:Top expressed in
416:
401:secondary oocyte
361:
359:Top expressed in
354:
333:
316:
306:
293:
282:
267:
260:
254:
243:
231:
215:
205:
192:
181:
166:
159:
153:
142:
128:
112:
106:
57:
50:
29:
21:
3260:
3259:
3255:
3254:
3253:
3251:
3250:
3249:
3225:
3224:
3223:
3211:
3203:
3201:
3196:
3108:Oxidoreductases
3094:
3070:Enzyme kinetics
3058:
3054:List of enzymes
3027:
2996:
2967:Catalytic triad
2945:
2940:
2910:
2905:
2881:
2847:
2836:
2806:
2793:
2747:
2675:
2645:
2626:
2556:
2527:
2478:
2464:
2406:
2386:
2357:
2334:Proline oxidase
2319:
2287:α-ketoglutarate
2285:
2271:
2252:
2233:
2214:
2210:Creatine kinase
2160:
2138:
2117:
2093:Arylformamidase
2069:
1993:
1956:
1954:are in Capitals
1944:
1940:and catabolism
1927:
1897:
1896:
1822:
1817:
1788:
1768:(3–4): 178–81.
1759:
1722:
1661:
1618:
1589:
1559:(10B): 2121–7.
1546:
1509:
1480:
1476:
1474:Further reading
1471:
1470:
1440:
1439:
1435:
1405:
1404:
1400:
1391:
1390:
1383:
1370:
1369:
1365:
1352:
1351:
1347:
1335:
1326:
1314:
1305:
1300:
1287:
1271:
1247:-imidazol-4-one
1227:
977:
951:View/Edit Mouse
946:View/Edit Human
909:
902:
899:Location (UCSC)
885:
864:
860:
856:
830:
809:
805:
801:
714:ENSG00000084110
607:
576:
555:
479:
470:
465:
461:
457:
453:
449:
445:
441:
437:
433:
419:
408:
405:skin of abdomen
403:
399:
395:
391:
387:
383:
379:
375:
371:
357:
301:
288:
280:
270:
269:
268:
261:
241:
218:Gene location (
200:
187:
179:
169:
168:
167:
160:
138:
115:Gene location (
104:HAL - orthologs
66:
53:
46:
23:
22:
15:
12:
11:
5:
3258:
3256:
3248:
3247:
3242:
3237:
3227:
3226:
3222:
3221:
3198:
3197:
3195:
3194:
3181:
3168:
3155:
3142:
3129:
3116:
3102:
3100:
3096:
3095:
3093:
3092:
3087:
3082:
3077:
3072:
3066:
3064:
3060:
3059:
3057:
3056:
3051:
3046:
3041:
3035:
3033:
3032:Classification
3029:
3028:
3026:
3025:
3020:
3015:
3010:
3004:
3002:
2998:
2997:
2995:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2953:
2951:
2947:
2946:
2941:
2939:
2938:
2931:
2924:
2916:
2907:
2906:
2904:
2903:
2898:
2892:
2890:
2883:
2882:
2880:
2879:
2874:
2869:
2864:
2858:
2856:
2849:
2848:
2837:
2835:
2834:
2827:
2820:
2812:
2803:
2802:
2799:
2798:
2795:
2794:
2792:
2791:
2786:
2776:
2774:
2760:
2753:
2752:
2749:
2748:
2746:
2745:
2731:
2730:
2725:
2720:
2715:
2710:
2704:
2702:
2688:
2681:
2680:
2677:
2676:
2674:
2673:
2668:
2663:
2657:
2655:
2647:
2646:
2644:
2643:
2637:
2635:
2628:
2627:
2625:
2624:
2619:
2607:
2606:
2601:
2585:
2584:
2579:
2567:
2565:
2558:
2557:
2555:
2554:
2549:
2544:
2538:
2536:
2529:
2528:
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2015:
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1995:
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1928:
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1911:
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1820:External links
1818:
1816:
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1786:
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1659:
1631:(10): 1950–4.
1625:Carcinogenesis
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1587:
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1237:-histidine to
1226:
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1202:. It converts
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541:lyase activity
538:
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320:RNA expression
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3049:Enzyme family
3047:
3045:
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3037:
3036:
3034:
3030:
3024:
3021:
3019:
3016:
3014:
3013:Cooperativity
3011:
3009:
3006:
3005:
3003:
2999:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2972:Oxyanion hole
2970:
2968:
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2955:
2954:
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2948:
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2696:
2695:PHENYLALANINE
2692:
2689:
2687:
2682:
2672:
2669:
2667:
2664:
2662:
2659:
2658:
2656:
2653:
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2499:
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2475:propionyl-CoA
2471:
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2159:
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2123:PHENYLALANINE
2120:
2114:
2111:
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2028:HMG-CoA lyase
2026:
2024:
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2019:
2016:
2014:
2011:
2009:
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1858:article is a
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1843:public domain
1840:
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1797:(1): E172–9.
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1598:(3): 209–15.
1597:
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1429:
1425:
1421:
1417:
1414:(1): 98–104.
1413:
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1388:
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1367:
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1240:
1232:
1224:
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1213:
1212:urocanic acid
1209:
1205:
1201:
1198:
1194:
1190:
1186:
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1179:
1175:
1163:
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1146:
1142:
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1118:
1114:
1111:
1109:
1108:Gene Ontology
1105:
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1099:
1096:
1093:
1090:
1086:
1083:
1080:
1078:
1074:
1071:
1068:
1066:
1062:
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1050:
1047:
1046:NiceZyme view
1044:
1042:
1038:
1035:
1032:
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1026:
1023:
1020:
1018:
1014:
1009:
1006:
1003:
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997:
994:
991:
989:
985:
980:
973:
968:
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952:
947:
943:
939:
936:
932:
925:
923:
920:
916:
912:
908:
905:
901:
897:
890:
888:
882:
878:
875:
869:
867:
863:
859:
853:
849:
846:
842:
835:
833:
827:
823:
820:
814:
812:
808:
804:
798:
794:
791:
789:RefSeq (mRNA)
787:
780:
779:
774:
770:
767:
761:
760:
755:
751:
748:
746:
742:
735:
734:
729:
725:
722:
716:
715:
710:
706:
703:
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697:
690:
689:
684:
680:
677:
671:
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656:
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637:
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630:
626:
619:
615:
610:
604:
601:
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586:
585:
583:
580:
579:
573:
570:
568:
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564:
562:
559:
558:
552:
549:
547:
544:
542:
539:
537:
534:
533:
531:
528:
527:
524:
523:Gene ontology
520:
516:
504:
499:
496:
494:
490:
482:
477:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
429:
426:
422:
417:
414:
404:
400:
396:
392:
388:
384:
380:
377:skin of thigh
376:
372:
368:
367:
364:
360:
355:
352:
351:
348:
346:
342:
340:
339:
335:
334:
331:
329:
325:
321:
317:
313:
305:
300:
296:
292:
287:
277:
273:
266:
259:
253:
246:
238:
234:
230:
225:
221:
216:
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204:
199:
195:
191:
186:
176:
172:
165:
158:
152:
145:
141:
135:
131:
127:
122:
118:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
61:
56:
49:
44:
39:
35:
30:
27:
19:
3186:Translocases
3183:
3170:
3157:
3144:
3131:
3121:Transferases
3118:
3105:
2962:Binding site
2861:
2780:Asparaginase
2758:oxaloacetate
2652:succinyl-CoA
2610:
2588:
2570:
2480:succinyl-CoA
2304:
2098:Kynureninase
2062:
1950:
1864:expanding it
1853:
1836:
1835:
1794:
1790:
1765:
1761:
1731:(5): 340–6.
1728:
1724:
1671:
1667:
1628:
1624:
1595:
1591:
1556:
1552:
1518:(3): 232–8.
1515:
1511:
1489:(2): 293–5.
1486:
1482:
1446:
1443:Biochemistry
1442:
1436:
1411:
1407:
1401:
1375:
1366:
1357:
1348:
1275:histidinemia
1272:
1244:
1238:
1228:
1215:
1196:
1188:
1184:
1173:
1172:
1034:BRENDA entry
884:
862:NP_001245263
858:NP_001245262
855:
829:
807:NM_001258334
803:NM_001258333
800:
776:
757:
731:
712:
686:
667:
647:
642:
447:skin of back
343:
336:
63:External IDs
26:
3240:Lyase stubs
2957:Active site
2460:Glutaminase
2426:glutathione
2135:(see below)
1512:Genes Immun
1231:deamination
1189:histidinase
1022:IntEnz view
982:Identifiers
467:granulocyte
393:skin of arm
373:human penis
302:93,355,166
289:93,324,630
201:95,996,365
188:95,972,662
41:Identifiers
3229:Categories
3160:Isomerases
3134:Hydrolases
3001:Regulation
2767:asparagine
2743:Tyrosinase
2562:METHIONINE
2533:ISOLEUCINE
2382:Agmatinase
2075:TRYPTOPHAN
1966:acetyl-CoA
1930:Metabolism
1725:Hum. Genet
1553:Genome Res
1343:, May 2017
1322:, May 2017
1298:References
1091:structures
1058:KEGG entry
1005:9013-75-6
459:belly cord
347:(ortholog)
84:HomoloGene
18:HAL (gene)
3039:EC number
2771:aspartate
2632:THREONINE
2451:glutamine
2447:glutamate
2422:glutamate
2296:HISTIDINE
2282:glutamate
2258:threonine
1938:synthesis
1269:Pathology
1204:histidine
1185:histidase
1011:Databases
887:NP_034531
866:NP_002099
832:NM_010401
811:NM_002108
633:Orthologs
572:cytoplasm
463:spermatid
92:GeneCards
3245:EC 4.3.1
3063:Kinetics
2987:Cofactor
2950:Activity
2735:tyrosine
2699:tyrosine
2686:fumarate
2418:cysteine
2363:arginine
2239:cysteine
2201:creatine
2158:pyruvate
2127:tyrosine
1811:15741241
1753:33960184
1745:15806399
1716:12477932
1655:18641401
1612:18280705
1583:15489334
1540:11183658
1532:20237496
1463:10220322
1408:Genomics
1339:–
1318:–
1285:See also
1251:cofactor
1225:Function
1191:) is an
1162:proteins
1150:articles
1138:articles
1095:RCSB PDB
935:Wikidata
612:Sources:
455:calvaria
397:monocyte
3219:Biology
3173:Ligases
2943:Enzymes
2739:melanin
2348:ALDH4A1
2325:proline
2220:alanine
2197:glycine
2172:glycine
2163:citrate
1999:LEUCINE
1942:enzymes
1782:2055114
1698:3074035
1676:Bibcode
1646:2556967
1503:7916645
1428:8530107
1341:Ensembl
1320:Ensembl
1208:ammonia
1181:4.3.1.3
1117:QuickGO
1082:profile
1065:MetaCyc
1000:CAS no.
993:4.3.1.3
745:UniProt
700:Ensembl
639:Species
618:QuickGO
567:cytosol
322:pattern
180:12q23.1
48:Aliases
3205:Portal
3147:Lyases
2840:lyases
2489:VALINE
2176:serine
1975:LYSINE
1832:(MeSH)
1809:
1780:
1751:
1743:
1714:
1707:139241
1704:
1696:
1653:
1643:
1610:
1581:
1574:528928
1571:
1538:
1530:
1501:
1461:
1426:
1193:enzyme
1145:PubMed
1127:Search
1113:AmiGO
1101:PDBsum
1041:ExPASy
1029:BRENDA
1017:IntEnz
988:EC no.
921:search
919:PubMed
778:P35492
759:P42357
655:Entrez
493:BioGPS
431:morula
389:oocyte
72:609457
3099:Types
2887:4.3.2
2853:4.3.1
2411:Other
2353:PYCR1
2063:(See
1856:lyase
1854:This
1749:S2CID
1694:JSTOR
1536:S2CID
1239:trans
1206:into
1077:PRIAM
688:15109
648:Mouse
643:Human
614:Amigo
385:blood
381:vulva
345:Mouse
338:Human
285:Start
220:Mouse
184:Start
117:Human
88:68229
80:96010
3191:list
3184:EC7
3178:list
3171:EC6
3165:list
3158:EC5
3152:list
3145:EC4
3139:list
3132:EC3
3126:list
3119:EC2
3113:list
3106:EC1
2846:4.3)
2654:→TCA
2395:→TCA
1860:stub
1807:PMID
1778:PMID
1741:PMID
1712:PMID
1651:PMID
1608:PMID
1579:PMID
1528:PMID
1499:PMID
1487:1216
1459:PMID
1424:PMID
1277:and
1210:and
1200:gene
1157:NCBI
1098:PDBe
1053:KEGG
669:3034
328:Bgee
276:Band
237:Chr.
175:Band
134:Chr.
68:OMIM
1799:doi
1795:289
1770:doi
1733:doi
1729:116
1702:PMC
1684:doi
1641:PMC
1633:doi
1600:doi
1569:PMC
1561:doi
1520:doi
1491:doi
1451:doi
1416:doi
1233:of
1197:HAL
1133:PMC
1089:PDB
501:n/a
443:lip
298:End
197:End
100:OMA
96:HAL
76:MGI
55:HAL
32:HAL
3231::
2844:EC
2756:G→
2741::
2684:G→
2473:G→
2453::
2428::
2280:G→
2203::
2156:G→
1936:,
1932::
1805:.
1793:.
1776:.
1766:56
1764:.
1747:.
1739:.
1727:.
1710:.
1700:.
1692:.
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1594:.
1577:.
1567:.
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1555:.
1551:.
1534:.
1526:.
1516:11
1514:.
1497:.
1485:.
1457:.
1447:38
1445:.
1422:.
1412:29
1410:.
1384:^
1374:.
1356:.
1327:^
1306:^
1281:.
1221:.
1187:,
1183:,
1178:EC
1115:/
616:/
304:bp
291:bp
203:bp
190:bp
98:;
94::
90:;
86::
82:;
78::
74:;
70::
3207::
3193:)
3189:(
3180:)
3176:(
3167:)
3163:(
3154:)
3150:(
3141:)
3137:(
3128:)
3124:(
3115:)
3111:(
2935:e
2928:t
2921:v
2842:(
2831:e
2824:t
2817:v
2782:/
2773:→
2769:→
2737:→
2701:→
2697:→
2650:→
2634:→
2614::
2597:/
2592::
2574::
2564:→
2535:→
2491:→
2477:→
2449:→
2424:→
2420:+
2391:→
2365:→
2346:/
2327:→
2298:→
2284:→
2260:→
2241:→
2222:→
2199:→
2178:→
2174:→
2161:→
2148:G
2129:→
2125:→
2086:/
2077:→
2001:→
1977:→
1964:→
1962:K
1922:e
1915:t
1908:v
1891:e
1884:t
1877:v
1866:.
1845:.
1813:.
1801::
1784:.
1772::
1755:.
1735::
1718:.
1686::
1678::
1657:.
1635::
1614:.
1602::
1585:.
1563::
1542:.
1522::
1505:.
1493::
1465:.
1453::
1430:.
1418::
1395:.
1378:.
1360:.
1245:H
1235:L
1217:L
1176:(
222:)
119:)
102::
20:)
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