320:
297:
194:
219:
585:
578:
571:
326:
225:
31:
3814:
1583:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromatin structure and affects transcription. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It
1674:
Since HDAC6 is dysregulated and/or implicated in several cancers and neurodegenerative disorders, pharmacological inhibition of this specific enzyme holds great therapeutic potential and could also limit side effects associated with pan-inhibitors of multiple HDAC enzymes. Selective inhibition of
57:
1683:
only when administered in high concentrations, which also produced off-target effects. The findings suggest that further study is needed to clarify data on anti-cancer effects of selective HDAC6 inhibitors.
3222:
2589:
Mahlknecht U, Schnittger S, Landgraf F, Schoch C, Ottmann OG, Hiddemann W, Hoelzer D (2001). "Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization".
1584:
contains an internal duplication of two catalytic domains that appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
3101:
Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, et al. (June 2007). "HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS".
3215:
333:
232:
1575:. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
1701:
1883:"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
3208:
3190:
1238:
1219:
155:
2002:"Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis"
3451:
1804:
1786:
3834:
2664:"Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways"
319:
3163:
2783:
Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, et al. (May 2002). "HDAC6 is a microtubule-associated deacetylase".
1502:
3533:
3002:
Voelter-Mahlknecht S, Mahlknecht U (July 2003). "Cloning and structural characterization of the human histone deacetylase 6 gene".
296:
1986:
1675:
HDAC6 as a strategy to treat cancers is however also subject of debate, since some HDAC6 inhibitors exhibited anti-tumor activity
1623:(SG) proteins and is instrumental in SG formation; pharmacological inhibition or genetic removal of HDAC6 abolished SG formation.
1509:
1773:
1752:
3426:
2873:"Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes"
3689:
1769:
3175:
218:
193:
54:
3804:
1748:
135:
1693:
2334:"Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models"
2236:"HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer"
332:
231:
3388:
3674:
325:
224:
3790:
3777:
3764:
3751:
3738:
3725:
3712:
3486:
3463:
3398:
3365:
3332:
3244:
3684:
3638:
3581:
3235:
3157:
1283:
143:
2210:
3586:
3305:
2414:
Chauchereau A, Mathieu M, de
Saintignon J, Ferreira R, Pritchard LL, Mishal Z, et al. (November 2004).
1264:
2750:"Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family"
2375:"Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family"
1657:
3607:
3526:
2416:"HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF"
2162:"The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response"
3679:
2707:"Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain"
2662:
Seigneurin-Berny D, Verdel A, Curtet S, Lemercier C, Garin J, Rousseaux S, Khochbin S (December 2001).
3436:
3110:
2926:"Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter"
2884:
2792:
1835:
207:
122:
2924:
Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, et al. (November 2002).
3643:
3416:
3315:
3200:
3181:
3169:
3033:"Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases"
1724:
1481:
1456:
1452:
1442:
1438:
1434:
1430:
1426:
1402:
1381:
1377:
1373:
1363:
1359:
1355:
1351:
3153:
3576:
3441:
3134:
2816:
2615:
2534:
2491:
1968:
167:
2332:
Depetter Y, Geurs S, De Vreese R, Goethals S, Vandoorn E, Laevens A, et al. (August 2019).
1485:
1460:
1406:
1347:
3068:"HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration"
1881:
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, et al. (December 1998).
3839:
3411:
3126:
3089:
3054:
3019:
2990:
2955:
2912:
2859:
2808:
2771:
2736:
2693:
2650:
2607:
2577:
2526:
2483:
2437:
2396:
2355:
2314:
2265:
2191:
2139:
2083:
2023:
1960:
1904:
1863:
584:
577:
570:
115:
47:
2283:
Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, Petrucelli L (July 2012).
3622:
3617:
3591:
3519:
3118:
3079:
3044:
3011:
2980:
2945:
2937:
2902:
2892:
2849:
2841:
2800:
2761:
2726:
2718:
2683:
2675:
2640:
2599:
2567:
2559:
2516:
2473:
2427:
2386:
2345:
2304:
2296:
2255:
2247:
2181:
2173:
2129:
2119:
2073:
2065:
2013:
1950:
1942:
1894:
1853:
1843:
412:
343:
287:
242:
163:
3669:
3653:
3566:
3293:
1925:
Geurs S, Clarisse D, Baele F, Franceus J, Desmet T, De
Bosscher K, D'hooghe M (May 2022).
387:
2034:
909:
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
3114:
2888:
2796:
2054:"Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis"
1839:
3818:
3707:
3648:
3468:
3431:
3403:
3355:
3350:
3337:
3287:
3249:
2309:
2284:
2260:
2235:
2186:
2161:
2134:
2107:
2078:
2053:
1708:
1620:
30:
2985:
2968:
2950:
2925:
2907:
2872:
2854:
2829:
2731:
2706:
2572:
2547:
2478:
2461:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
741:
736:
731:
726:
721:
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711:
706:
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681:
676:
671:
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661:
656:
651:
646:
641:
636:
631:
626:
3828:
3612:
3571:
3495:
3421:
3370:
3194:
2941:
2688:
2679:
2663:
1972:
1858:
1823:
1664:
1627:
1606:
1599:
613:
2619:
2538:
2495:
1824:"Three proteins define a class of human histone deacetylases related to yeast Hda1p"
1119:
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
147:
3561:
3277:
3257:
3138:
2828:
Kirsh O, Seeler JS, Pichler A, Gast A, MĂĽller S, Miska E, et al. (June 2002).
2820:
405:
184:
1603:
2629:"Isolation and characterization of mammalian HDAC10, a novel histone deacetylase"
171:
3785:
3720:
3556:
3345:
3272:
3262:
1809:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1791:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3813:
2877:
Proceedings of the
National Academy of Sciences of the United States of America
2845:
2251:
1828:
Proceedings of the
National Academy of Sciences of the United States of America
488:
3500:
3383:
3300:
1926:
1668:
304:
201:
151:
2285:"Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation"
1899:
1882:
3759:
3733:
3476:
3231:
2722:
1183:
1124:
positive regulation of mitophagy in response to mitochondrial depolarization
548:
426:
371:
358:
270:
257:
159:
3130:
3093:
3058:
3049:
3032:
3023:
2994:
2959:
2916:
2897:
2863:
2812:
2775:
2766:
2749:
2740:
2697:
2654:
2645:
2628:
2611:
2581:
2563:
2441:
2432:
2415:
2400:
2391:
2374:
2359:
2318:
2269:
2195:
2143:
2087:
2027:
2018:
2001:
1964:
1955:
1931:
a lean inhibitor strategy: screening, synthesis, and biological evaluation"
1908:
1867:
1848:
2969:"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase"
2830:"The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase"
2530:
2487:
2124:
2000:
Krishnamurthy K, Wang G, Silva J, Condie BG, Bieberich E (February 2007).
1549:
1544:
884:
protein quality control for misfolded or incompletely synthesized proteins
3378:
3015:
2300:
2211:"Targeting an enzyme in fat cells drives rapid weight loss in obese mice"
2069:
1641:
1533:
1328:
1309:
3122:
3031:
Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S (February 2004).
3320:
2234:
Xu G, Niu L, Wang Y, Yang G, Zhu X, Yao Y, et al. (October 2022).
2177:
1946:
1592:
1295:
1250:
1004:
positive regulation of hydrogen peroxide-mediated programmed cell death
3084:
3067:
2603:
2350:
2333:
92:
88:
84:
80:
76:
3772:
3542:
3267:
2521:
2504:
1697:
1645:
1634:
1588:
1565:
1517:
1205:
732:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
2967:
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E (February 2003).
2804:
3746:
3446:
2462:"What's up and down with histone deacetylation and transcription?"
2052:
Gao YS, Hubbert CC, Lu J, Lee YS, Lee JY, Yao TP (December 2007).
1712:
1613:
1059:
positive regulation of chaperone-mediated protein complex assembly
2035:"Lipid helps cells find their way by keeping their 'antennae' up"
1168:
1164:
3310:
3282:
1572:
593:
139:
3515:
3204:
3066:
Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP (Nov–Dec 2007).
1069:
negative regulation of protein-containing complex disassembly
2627:
Kao HY, Lee CH, Komarov A, Han CC, Evans RM (January 2002).
1927:"Identification of mercaptoacetamide-based HDAC6 inhibitors
1609:. As a result the enzyme encourages cancer cell metastasis.
647:
NAD-dependent histone deacetylase activity (H3-K14 specific)
3511:
1612:
HDAC6 affects transcription and translation by regulating
1029:
negative regulation of hydrogen peroxide metabolic process
2871:
Hook SS, Orian A, Cowley SM, Eisenman RN (October 2002).
2548:"BCoR, a novel corepressor involved in BCL-6 repression"
2546:
Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000).
395:
1144:
positive regulation of peptidyl-serine phosphorylation
3802:
2748:
Gao L, Cueto MA, Asselbergs F, Atadja P (July 2002).
2373:
Gao L, Cueto MA, Asselbergs F, Atadja P (July 2002).
560:
1822:
Grozinger CM, Hassig CA, Schreiber SL (April 1999).
894:
cellular response to topologically incorrect protein
662:
polyubiquitin modification-dependent protein binding
3698:
3662:
3631:
3600:
3549:
3485:
3462:
3397:
3364:
3331:
3243:
1474:
1425:
1395:
1346:
1079:
negative regulation of microtubule depolymerization
1049:
negative regulation of transcription, DNA-templated
904:
regulation of establishment of protein localization
1765:
1763:
1761:
1744:
1742:
1740:
126:, CPBHM, HD6, PPP1R90, JM21, histone deacetylase 6
2705:Tong JJ, Liu J, Bertos NR, Yang XJ (March 2002).
1920:
1918:
1044:regulation of androgen receptor signaling pathway
342:
241:
1702:Zinc finger and BTB domain-containing protein 16
1663:Over expression of this protein correlates with
974:positive regulation of epithelial cell migration
1656:Mutations in this gene have been associated to
16:Protein-coding gene in the species Homo sapiens
1770:GRCm38: Ensembl release 89: ENSMUSG00000031161
1134:positive regulation of protein oligomerization
1039:negative regulation of oxidoreductase activity
3527:
3216:
2160:Kwon S, Zhang Y, Matthias P (December 2007).
994:polyubiquitinated misfolded protein transport
964:ubiquitin-dependent protein catabolic process
8:
2505:"Transcriptional control. Sinful repression"
3004:International Journal of Molecular Medicine
1749:GRCh38: Ensembl release 89: ENSG00000094631
3534:
3520:
3512:
3223:
3209:
3201:
3191:United States National Library of Medicine
2112:Journal of Biomedicine & Biotechnology
1987:"Entrez Gene: HDAC6 histone deacetylase 6"
1422:
1343:
1179:
954:regulation of transcription, DNA-templated
939:positive regulation of signal transduction
609:
383:
282:
179:
65:
3156:at the U.S. National Library of Medicine
3083:
3048:
2984:
2949:
2906:
2896:
2853:
2765:
2730:
2687:
2644:
2571:
2520:
2477:
2431:
2390:
2349:
2308:
2259:
2185:
2133:
2123:
2106:Aldana-Masangkay GI, Sakamoto KM (2011).
2101:
2099:
2097:
2077:
2017:
1954:
1898:
1857:
1847:
1667:and cell survival. HDAC6 also encourages
1591:of the cell, which is necessary prior to
1064:regulation of gene expression, epigenetic
1014:regulation of signaling receptor activity
3189:This article incorporates text from the
1009:regulation of microtubule-based movement
989:regulation of autophagy of mitochondrion
3809:
1736:
1619:HDAC6 is required in the formation of
1139:protein-containing complex disassembly
1094:cellular response to hydrogen peroxide
1054:cellular response to misfolded protein
979:regulation of fat cell differentiation
20:
3452:Activation-induced cytidine deaminase
2155:
2153:
742:acetylspermidine deacetylase activity
347:
308:
303:
246:
205:
200:
7:
3037:The Journal of Biological Chemistry
2754:The Journal of Biological Chemistry
2633:The Journal of Biological Chemistry
2379:The Journal of Biological Chemistry
2006:The Journal of Biological Chemistry
2460:Pazin MJ, Kadonaga JT (May 1997).
1626:HDAC6 bonds with high affinity to
1471:
1392:
1319:
1300:
1274:
1255:
1229:
1210:
929:negative regulation of proteolysis
565:
535:choroid plexus of fourth ventricle
515:central gray substance of midbrain
483:
421:
400:
14:
1568:that in humans is encoded by the
3812:
2942:10.1128/MCB.22.22.7982-7992.2002
2680:10.1128/MCB.21.23.8035-8044.2001
722:ubiquitin protein ligase binding
583:
576:
569:
531:dorsomedial hypothalamic nucleus
331:
324:
318:
295:
230:
223:
217:
192:
29:
3234:: carbon-nitrogen non-peptide (
2338:International Journal of Cancer
959:regulation of protein stability
919:intracellular protein transport
763:perinuclear region of cytoplasm
3427:Inosine monophosphate synthase
2930:Molecular and Cellular Biology
2668:Molecular and Cellular Biology
2592:Cytogenetics and Cell Genetics
2058:Molecular and Cellular Biology
793:microtubule associated complex
594:More reference expression data
549:More reference expression data
437:right hemisphere of cerebellum
1:
2986:10.1016/S1097-2765(03)00038-8
2479:10.1016/S0092-8674(00)80211-1
2108:"The role of HDAC6 in cancer"
1104:dendritic spine morphogenesis
949:response to misfolded protein
944:peptidyl-lysine deacetylation
889:response to organic substance
316:
215:
1114:regulation of macroautophagy
984:transcription, DNA-templated
737:protein deacetylase activity
727:tubulin deacetylase activity
687:histone deacetylase activity
3835:Genes on human chromosome X
3168:human gene location in the
999:response to toxic substance
808:histone deacetylase complex
627:histone deacetylase binding
3856:
3389:Protein-arginine deiminase
3311:Fatty acid amide hydrolase
3180:human gene details in the
2252:10.1038/s41419-022-05335-1
1019:protein polyubiquitination
969:mitochondrion localization
863:protein-containing complex
3690:Michaelis–Menten kinetics
1805:"Mouse PubMed Reference:"
1787:"Human PubMed Reference:"
1707:HDAC6 interacts with SG (
1548:
1543:
1539:
1532:
1516:
1497:
1478:
1449:
1418:
1399:
1370:
1339:
1326:
1322:
1307:
1303:
1294:
1281:
1277:
1262:
1258:
1249:
1236:
1232:
1217:
1213:
1204:
1189:
1182:
1178:
1162:
914:response to growth factor
632:misfolded protein binding
612:
608:
591:
568:
559:
546:
527:medullary collecting duct
495:
486:
433:
424:
394:
386:
382:
365:
352:
315:
294:
285:
281:
264:
251:
214:
191:
182:
178:
133:
130:
120:
113:
108:
73:
68:
51:
46:
41:
37:
28:
23:
3582:Diffusion-limited enzyme
3158:Medical Subject Headings
2846:10.1093/emboj/21.11.2682
2289:Human Molecular Genetics
2240:Cell Death & Disease
1692:HDAC6 has been shown to
1154:spermidine deacetylation
934:histone H3 deacetylation
3306:Aspartylglucosaminidase
2552:Genes & Development
2209:Lavars N (2022-01-18).
2166:Genes & Development
1935:Chemical Communications
1149:polyamine deacetylation
1034:regulation of autophagy
838:cytoplasmic microtubule
3050:10.1074/jbc.M310997200
2898:10.1073/pnas.172511699
2767:10.1074/jbc.M111871200
2711:Nucleic Acids Research
2646:10.1074/jbc.M108931200
2564:10.1101/gad.14.14.1810
2503:Wolffe AP (May 1997).
2433:10.1038/sj.onc.1208128
2392:10.1074/jbc.M111871200
2019:10.1074/jbc.M607779200
1900:10.1093/dnares/5.6.355
1849:10.1073/pnas.96.9.4868
1503:Chr X: 48.8 – 48.82 Mb
1129:chromatin organization
677:dynein complex binding
3675:Eadie–Hofstee diagram
3608:Allosteric regulation
2723:10.1093/nar/30.5.1114
1633:HDAC6 is involved in
1614:heat-shock protein 90
1562:Histone deacetylase 6
1089:histone deacetylation
1084:lysosome localization
1024:protein deacetylation
899:tubulin deacetylation
697:alpha-tubulin binding
682:Hsp90 protein binding
349:X A1.1|X 3.58 cM
3685:Lineweaver–Burk plot
3437:GTP cyclohydrolase I
3154:HDAC6+protein,+human
3016:10.3892/ijmm.12.1.87
2070:10.1128/MCB.00393-07
1510:Chr X: 7.8 – 7.81 Mb
1099:collateral sprouting
707:beta-tubulin binding
652:beta-catenin binding
310:X chromosome (mouse)
208:X chromosome (human)
69:List of PDB id codes
42:Available structures
3417:Adenosine deaminase
3316:Histone deacetylase
3182:UCSC Genome Browser
3170:UCSC Genome Browser
3123:10.1038/nature05853
3115:2007Natur.447..860P
2889:2002PNAS...9913425H
2883:(21): 13425–13430.
2797:2002Natur.417..455H
2760:(28): 25748–25755.
2385:(28): 25748–25755.
2125:10.1155/2011/875824
1840:1999PNAS...96.4868G
1725:Histone deacetylase
1658:Alzheimer's disease
1640:HDAC6 deacetylates
879:Hsp90 deacetylation
783:multivesicular body
692:microtubule binding
672:tau protein binding
507:islet of Langerhans
473:ganglionic eminence
445:right lobe of liver
3644:Enzyme superfamily
3577:Enzyme promiscuity
3442:Cytidine deaminase
3401:: Cyclic amidines/
3368:: Linear amidines/
3193:, which is in the
2301:10.1093/hmg/dds125
2178:10.1101/gad.461107
1947:10.1039/D2CC01550A
1652:Clinical relevance
1284:ENSMUSG00000031161
924:aggresome assembly
872:Biological process
751:Cellular component
717:hydrolase activity
620:Molecular function
441:anterior pituitary
3800:
3799:
3509:
3508:
3412:Guanine deaminase
3247:: Linear amides /
3109:(7146): 859–863.
3085:10.4161/auto.5050
2936:(22): 7982–7992.
2840:(11): 2682–2691.
2791:(6887): 455–458.
2674:(23): 8035–8044.
2604:10.1159/000056967
2558:(14): 1810–1823.
2426:(54): 8777–8784.
2351:10.1002/ijc.32169
2295:(13): 2936–2945.
2172:(24): 3381–3394.
2064:(24): 8637–8647.
2032:*Lay summary in:
1941:(42): 6239–6242.
1671:of cancer cells.
1559:
1558:
1555:
1554:
1528:
1527:
1493:
1492:
1468:
1467:
1414:
1413:
1389:
1388:
1335:
1334:
1316:
1315:
1290:
1289:
1271:
1270:
1245:
1244:
1226:
1225:
1174:
1173:
848:neuron projection
833:cell leading edge
702:ubiquitin binding
637:metal ion binding
604:
603:
600:
599:
555:
554:
542:
541:
503:perirhinal cortex
499:entorhinal cortex
480:
479:
378:
377:
277:
276:
172:HDAC6 - orthologs
104:
103:
100:
99:
52:Ortholog search:
3847:
3817:
3816:
3808:
3680:Hanes–Woolf plot
3623:Enzyme activator
3618:Enzyme inhibitor
3592:Enzyme catalysis
3536:
3529:
3522:
3513:
3335:: Cyclic amides/
3225:
3218:
3211:
3202:
3142:
3097:
3087:
3062:
3052:
3043:(9): 7685–7691.
3027:
2998:
2988:
2963:
2953:
2920:
2910:
2900:
2867:
2857:
2834:The EMBO Journal
2824:
2779:
2769:
2744:
2734:
2717:(5): 1114–1123.
2701:
2691:
2658:
2648:
2623:
2598:(1–2): 135–136.
2585:
2575:
2542:
2524:
2522:10.1038/387016a0
2499:
2481:
2446:
2445:
2435:
2411:
2405:
2404:
2394:
2370:
2364:
2363:
2353:
2329:
2323:
2322:
2312:
2280:
2274:
2273:
2263:
2231:
2225:
2224:
2222:
2221:
2206:
2200:
2199:
2189:
2157:
2148:
2147:
2137:
2127:
2103:
2092:
2091:
2081:
2049:
2043:
2042:
2031:
2021:
2012:(5): 3379–3390.
1997:
1991:
1990:
1983:
1977:
1976:
1958:
1922:
1913:
1912:
1902:
1878:
1872:
1871:
1861:
1851:
1834:(9): 4868–4873.
1819:
1813:
1812:
1801:
1795:
1794:
1783:
1777:
1767:
1756:
1746:
1644:residue T178 on
1598:HDAC encourages
1587:It retracts the
1541:
1540:
1512:
1505:
1488:
1472:
1463:
1423:
1419:RefSeq (protein)
1409:
1393:
1384:
1344:
1320:
1301:
1275:
1256:
1230:
1211:
1180:
657:zinc ion binding
610:
596:
587:
580:
573:
566:
551:
491:
489:Top expressed in
484:
469:ventricular zone
429:
427:Top expressed in
422:
401:
384:
374:
361:
350:
335:
328:
322:
311:
299:
283:
273:
260:
249:
234:
227:
221:
210:
196:
180:
174:
125:
118:
95:
66:
60:
39:
38:
33:
21:
3855:
3854:
3850:
3849:
3848:
3846:
3845:
3844:
3825:
3824:
3823:
3811:
3803:
3801:
3796:
3708:Oxidoreductases
3694:
3670:Enzyme kinetics
3658:
3654:List of enzymes
3627:
3596:
3567:Catalytic triad
3545:
3540:
3510:
3505:
3481:
3469:Aminohydrolases
3467:
3458:
3404:Aminohydrolases
3402:
3393:
3369:
3360:
3338:Amidohydrolases
3336:
3327:
3250:Amidohydrolases
3248:
3239:
3229:
3150:
3145:
3100:
3065:
3030:
3001:
2966:
2923:
2870:
2827:
2805:10.1038/417455a
2782:
2747:
2704:
2661:
2626:
2588:
2545:
2515:(6628): 16–17.
2502:
2459:
2455:
2453:Further reading
2450:
2449:
2413:
2412:
2408:
2372:
2371:
2367:
2331:
2330:
2326:
2282:
2281:
2277:
2233:
2232:
2228:
2219:
2217:
2208:
2207:
2203:
2159:
2158:
2151:
2105:
2104:
2095:
2051:
2050:
2046:
2041:. July 9, 2012.
2033:
1999:
1998:
1994:
1985:
1984:
1980:
1956:1854/LU-8752799
1924:
1923:
1916:
1880:
1879:
1875:
1821:
1820:
1816:
1803:
1802:
1798:
1785:
1784:
1780:
1768:
1759:
1747:
1738:
1733:
1721:
1690:
1654:
1581:
1550:View/Edit Mouse
1545:View/Edit Human
1508:
1501:
1498:Location (UCSC)
1484:
1480:
1459:
1455:
1451:
1445:
1441:
1437:
1433:
1429:
1405:
1401:
1380:
1376:
1372:
1366:
1362:
1358:
1354:
1350:
1265:ENSG00000094631
1158:
1109:cilium assembly
867:
788:cell projection
746:
667:protein binding
592:
582:
581:
575:
574:
547:
538:
533:
529:
525:
521:
517:
513:
509:
505:
501:
487:
476:
471:
467:
463:
459:
455:
451:
447:
443:
439:
425:
369:
356:
348:
338:
337:
336:
329:
309:
286:Gene location (
268:
255:
247:
237:
236:
235:
228:
206:
183:Gene location (
134:
121:
114:
75:
53:
17:
12:
11:
5:
3853:
3851:
3843:
3842:
3837:
3827:
3826:
3822:
3821:
3798:
3797:
3795:
3794:
3781:
3768:
3755:
3742:
3729:
3716:
3702:
3700:
3696:
3695:
3693:
3692:
3687:
3682:
3677:
3672:
3666:
3664:
3660:
3659:
3657:
3656:
3651:
3646:
3641:
3635:
3633:
3632:Classification
3629:
3628:
3626:
3625:
3620:
3615:
3610:
3604:
3602:
3598:
3597:
3595:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3553:
3551:
3547:
3546:
3541:
3539:
3538:
3531:
3524:
3516:
3507:
3506:
3504:
3503:
3498:
3492:
3490:
3483:
3482:
3480:
3479:
3473:
3471:
3460:
3459:
3457:
3456:
3455:
3454:
3449:
3439:
3434:
3432:DCMP deaminase
3429:
3424:
3419:
3414:
3408:
3406:
3395:
3394:
3392:
3391:
3386:
3381:
3375:
3373:
3371:Ureohydrolases
3362:
3361:
3359:
3358:
3356:Dihydroorotase
3353:
3351:Beta-lactamase
3348:
3342:
3340:
3329:
3328:
3326:
3325:
3324:
3323:
3313:
3308:
3303:
3298:
3297:
3296:
3291:
3288:Aspartoacylase
3285:
3275:
3270:
3265:
3260:
3254:
3252:
3241:
3240:
3230:
3228:
3227:
3220:
3213:
3205:
3186:
3185:
3173:
3161:
3149:
3148:External links
3146:
3144:
3143:
3098:
3078:(6): 643–645.
3063:
3028:
2999:
2979:(2): 437–444.
2973:Molecular Cell
2964:
2921:
2868:
2825:
2780:
2745:
2702:
2659:
2639:(1): 187–193.
2624:
2586:
2543:
2500:
2472:(3): 325–328.
2456:
2454:
2451:
2448:
2447:
2406:
2365:
2344:(3): 735–747.
2324:
2275:
2226:
2201:
2149:
2093:
2044:
1992:
1978:
1914:
1893:(6): 355–364.
1873:
1814:
1796:
1778:
1757:
1735:
1734:
1732:
1729:
1728:
1727:
1720:
1717:
1709:Stress granule
1689:
1686:
1653:
1650:
1621:stress granule
1602:and catalyzes
1580:
1577:
1557:
1556:
1553:
1552:
1547:
1537:
1536:
1530:
1529:
1526:
1525:
1523:
1521:
1514:
1513:
1506:
1499:
1495:
1494:
1491:
1490:
1476:
1475:
1469:
1466:
1465:
1447:
1446:
1420:
1416:
1415:
1412:
1411:
1397:
1396:
1390:
1387:
1386:
1368:
1367:
1341:
1337:
1336:
1333:
1332:
1324:
1323:
1317:
1314:
1313:
1305:
1304:
1298:
1292:
1291:
1288:
1287:
1279:
1278:
1272:
1269:
1268:
1260:
1259:
1253:
1247:
1246:
1243:
1242:
1234:
1233:
1227:
1224:
1223:
1215:
1214:
1208:
1202:
1201:
1196:
1191:
1187:
1186:
1176:
1175:
1172:
1171:
1160:
1159:
1157:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
875:
873:
869:
868:
866:
865:
860:
855:
850:
845:
840:
835:
830:
825:
823:inclusion body
820:
815:
810:
805:
803:dynein complex
800:
795:
790:
785:
780:
775:
770:
765:
760:
754:
752:
748:
747:
745:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
642:enzyme binding
639:
634:
629:
623:
621:
617:
616:
606:
605:
602:
601:
598:
597:
589:
588:
563:
557:
556:
553:
552:
544:
543:
540:
539:
537:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
493:
492:
481:
478:
477:
475:
474:
470:
466:
462:
458:
457:body of uterus
454:
450:
446:
442:
438:
434:
431:
430:
418:
417:
409:
398:
392:
391:
388:RNA expression
380:
379:
376:
375:
367:
363:
362:
354:
351:
346:
340:
339:
330:
323:
317:
313:
312:
307:
301:
300:
292:
291:
279:
278:
275:
274:
266:
262:
261:
253:
250:
245:
239:
238:
229:
222:
216:
212:
211:
204:
198:
197:
189:
188:
176:
175:
132:
128:
127:
119:
111:
110:
106:
105:
102:
101:
98:
97:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3852:
3841:
3838:
3836:
3833:
3832:
3830:
3820:
3815:
3810:
3806:
3792:
3788:
3787:
3782:
3779:
3775:
3774:
3769:
3766:
3762:
3761:
3756:
3753:
3749:
3748:
3743:
3740:
3736:
3735:
3730:
3727:
3723:
3722:
3717:
3714:
3710:
3709:
3704:
3703:
3701:
3697:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3667:
3665:
3661:
3655:
3652:
3650:
3649:Enzyme family
3647:
3645:
3642:
3640:
3637:
3636:
3634:
3630:
3624:
3621:
3619:
3616:
3614:
3613:Cooperativity
3611:
3609:
3606:
3605:
3603:
3599:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3572:Oxyanion hole
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3554:
3552:
3548:
3544:
3537:
3532:
3530:
3525:
3523:
3518:
3517:
3514:
3502:
3501:Thiaminase II
3499:
3497:
3496:Riboflavinase
3494:
3493:
3491:
3488:
3484:
3478:
3475:
3474:
3472:
3470:
3465:
3461:
3453:
3450:
3448:
3445:
3444:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3422:AMP deaminase
3420:
3418:
3415:
3413:
3410:
3409:
3407:
3405:
3400:
3396:
3390:
3387:
3385:
3382:
3380:
3377:
3376:
3374:
3372:
3367:
3363:
3357:
3354:
3352:
3349:
3347:
3344:
3343:
3341:
3339:
3334:
3330:
3322:
3319:
3318:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3295:
3292:
3289:
3286:
3284:
3281:
3280:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3255:
3253:
3251:
3246:
3242:
3237:
3233:
3226:
3221:
3219:
3214:
3212:
3207:
3206:
3203:
3199:
3198:
3196:
3195:public domain
3192:
3183:
3179:
3178:
3174:
3171:
3167:
3166:
3162:
3159:
3155:
3152:
3151:
3147:
3140:
3136:
3132:
3128:
3124:
3120:
3116:
3112:
3108:
3104:
3099:
3095:
3091:
3086:
3081:
3077:
3073:
3069:
3064:
3060:
3056:
3051:
3046:
3042:
3038:
3034:
3029:
3025:
3021:
3017:
3013:
3009:
3005:
3000:
2996:
2992:
2987:
2982:
2978:
2974:
2970:
2965:
2961:
2957:
2952:
2947:
2943:
2939:
2935:
2931:
2927:
2922:
2918:
2914:
2909:
2904:
2899:
2894:
2890:
2886:
2882:
2878:
2874:
2869:
2865:
2861:
2856:
2851:
2847:
2843:
2839:
2835:
2831:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2786:
2781:
2777:
2773:
2768:
2763:
2759:
2755:
2751:
2746:
2742:
2738:
2733:
2728:
2724:
2720:
2716:
2712:
2708:
2703:
2699:
2695:
2690:
2685:
2681:
2677:
2673:
2669:
2665:
2660:
2656:
2652:
2647:
2642:
2638:
2634:
2630:
2625:
2621:
2617:
2613:
2609:
2605:
2601:
2597:
2593:
2587:
2583:
2579:
2574:
2569:
2565:
2561:
2557:
2553:
2549:
2544:
2540:
2536:
2532:
2528:
2523:
2518:
2514:
2510:
2506:
2501:
2497:
2493:
2489:
2485:
2480:
2475:
2471:
2467:
2463:
2458:
2457:
2452:
2443:
2439:
2434:
2429:
2425:
2421:
2417:
2410:
2407:
2402:
2398:
2393:
2388:
2384:
2380:
2376:
2369:
2366:
2361:
2357:
2352:
2347:
2343:
2339:
2335:
2328:
2325:
2320:
2316:
2311:
2306:
2302:
2298:
2294:
2290:
2286:
2279:
2276:
2271:
2267:
2262:
2257:
2253:
2249:
2245:
2241:
2237:
2230:
2227:
2216:
2212:
2205:
2202:
2197:
2193:
2188:
2183:
2179:
2175:
2171:
2167:
2163:
2156:
2154:
2150:
2145:
2141:
2136:
2131:
2126:
2121:
2117:
2113:
2109:
2102:
2100:
2098:
2094:
2089:
2085:
2080:
2075:
2071:
2067:
2063:
2059:
2055:
2048:
2045:
2040:
2039:phys.org/news
2036:
2029:
2025:
2020:
2015:
2011:
2007:
2003:
1996:
1993:
1988:
1982:
1979:
1974:
1970:
1966:
1962:
1957:
1952:
1948:
1944:
1940:
1936:
1932:
1930:
1921:
1919:
1915:
1910:
1906:
1901:
1896:
1892:
1888:
1884:
1877:
1874:
1869:
1865:
1860:
1855:
1850:
1845:
1841:
1837:
1833:
1829:
1825:
1818:
1815:
1810:
1806:
1800:
1797:
1792:
1788:
1782:
1779:
1775:
1771:
1766:
1764:
1762:
1758:
1754:
1750:
1745:
1743:
1741:
1737:
1730:
1726:
1723:
1722:
1718:
1716:
1714:
1710:
1705:
1703:
1699:
1695:
1687:
1685:
1682:
1678:
1672:
1670:
1666:
1665:tumorigenesis
1661:
1659:
1651:
1649:
1647:
1643:
1638:
1637:sensitivity.
1636:
1631:
1629:
1628:ubiquitinated
1624:
1622:
1617:
1615:
1610:
1608:
1607:deacetylation
1605:
1601:
1600:cell motility
1596:
1594:
1590:
1585:
1578:
1576:
1574:
1571:
1567:
1563:
1551:
1546:
1542:
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1535:
1531:
1524:
1522:
1519:
1515:
1511:
1507:
1504:
1500:
1496:
1489:
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1483:
1477:
1473:
1470:
1464:
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1458:
1454:
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1436:
1432:
1428:
1424:
1421:
1417:
1410:
1408:
1404:
1398:
1394:
1391:
1385:
1383:
1379:
1375:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1342:
1340:RefSeq (mRNA)
1338:
1331:
1330:
1325:
1321:
1318:
1312:
1311:
1306:
1302:
1299:
1297:
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1197:
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1161:
1155:
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1147:
1145:
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1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
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942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
876:
874:
871:
870:
864:
861:
859:
856:
854:
851:
849:
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844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
755:
753:
750:
749:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
712:actin binding
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
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658:
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648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
622:
619:
618:
615:
614:Gene ontology
611:
607:
595:
590:
586:
579:
572:
567:
564:
562:
558:
550:
545:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
497:
494:
490:
485:
482:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
435:
432:
428:
423:
420:
419:
416:
414:
410:
408:
407:
403:
402:
399:
397:
393:
389:
385:
381:
373:
368:
364:
360:
355:
345:
341:
334:
327:
321:
314:
306:
302:
298:
293:
289:
284:
280:
272:
267:
263:
259:
254:
244:
240:
233:
226:
220:
213:
209:
203:
199:
195:
190:
186:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
129:
124:
117:
112:
107:
96:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3786:Translocases
3783:
3770:
3757:
3744:
3731:
3721:Transferases
3718:
3705:
3562:Binding site
3278:Aminoacylase
3258:Asparaginase
3188:
3187:
3176:
3164:
3106:
3102:
3075:
3071:
3040:
3036:
3010:(1): 87–93.
3007:
3003:
2976:
2972:
2933:
2929:
2880:
2876:
2837:
2833:
2788:
2784:
2757:
2753:
2714:
2710:
2671:
2667:
2636:
2632:
2595:
2591:
2555:
2551:
2512:
2508:
2469:
2465:
2423:
2419:
2409:
2382:
2378:
2368:
2341:
2337:
2327:
2292:
2288:
2278:
2243:
2239:
2229:
2218:. Retrieved
2214:
2204:
2169:
2165:
2115:
2111:
2061:
2057:
2047:
2038:
2009:
2005:
1995:
1981:
1938:
1934:
1928:
1890:
1887:DNA Research
1886:
1876:
1831:
1827:
1817:
1808:
1799:
1790:
1781:
1706:
1691:
1688:Interactions
1680:
1676:
1673:
1662:
1655:
1639:
1632:
1625:
1618:
1611:
1597:
1586:
1582:
1569:
1561:
1560:
1482:NP_001123888
1479:
1457:NP_001308160
1453:NP_001308159
1450:
1443:NP_001308158
1439:NP_001308157
1435:NP_001308156
1431:NP_001308155
1427:NP_001308154
1403:NM_001130416
1400:
1382:NM_001321231
1378:NM_001321230
1374:NM_001321229
1371:
1364:NM_001321228
1360:NM_001321227
1356:NM_001321226
1352:NM_001321225
1327:
1308:
1282:
1263:
1237:
1218:
1198:
1193:
449:right testis
411:
404:
131:External IDs
74:
18:
3557:Active site
3466:: Nitriles/
3346:Barbiturase
3273:Biotinidase
3263:Glutaminase
2246:(10): 888.
853:nucleoplasm
773:microtubule
461:right ovary
453:left testis
269:48,824,982
256:48,801,377
109:Identifiers
3829:Categories
3760:Isomerases
3734:Hydrolases
3601:Regulation
3384:Agmatinase
3301:Ceramidase
3232:Hydrolases
2220:2022-01-18
2118:: 875824.
1776:, May 2017
1755:, May 2017
1731:References
1711:) protein
1669:metastasis
1630:proteins.
813:perikaryon
465:left ovary
415:(ortholog)
370:7,814,128
357:7,796,359
152:HomoloGene
3639:EC number
3477:Nitrilase
3072:Autophagy
2215:New Atlas
1973:248527466
1616:(Hsp90).
1604:α-tubulin
1486:NP_034543
1461:NP_006035
1407:NM_010413
1348:NM_006044
1184:Orthologs
1074:autophagy
858:cytoplasm
843:cell body
798:aggresome
519:CA3 field
160:GeneCards
3840:EC 3.5.1
3663:Kinetics
3587:Cofactor
3550:Activity
3379:Arginase
3131:17568747
3094:17912024
3059:14670976
3024:12792815
2995:12620231
2960:12391164
2917:12354939
2864:12032081
2813:12024216
2776:11948178
2741:11861901
2698:11689694
2655:11677242
2620:41821644
2612:11474198
2582:10898795
2539:29803420
2496:11488594
2442:15467736
2420:Oncogene
2401:11948178
2360:30694564
2319:22492994
2270:36270986
2196:18079183
2144:21076528
2088:17938201
2028:17105725
1965:35510683
1909:10048485
1868:10220385
1772:–
1751:–
1719:See also
1694:interact
1677:in vitro
1642:tyrosine
1579:Function
1534:Wikidata
1163:Sources:
828:dendrite
523:epiblast
511:yolk sac
3819:Biology
3773:Ligases
3543:Enzymes
3489:: Other
3321:Sirtuin
3139:4365061
3111:Bibcode
2885:Bibcode
2821:4373254
2793:Bibcode
2531:9139815
2488:9150131
2310:3373241
2261:9587286
2187:2113037
2135:2975074
2079:2169396
1836:Bibcode
1774:Ensembl
1753:Ensembl
1681:in vivo
1593:mitosis
1296:UniProt
1251:Ensembl
1190:Species
1169:QuickGO
778:nucleus
768:caveola
758:cytosol
390:pattern
248:Xp11.23
148:1333752
116:Aliases
3805:Portal
3747:Lyases
3487:3.5.99
3290:(ACY2)
3268:Urease
3160:(MeSH)
3137:
3129:
3103:Nature
3092:
3057:
3022:
2993:
2958:
2951:134736
2948:
2915:
2908:129689
2905:
2862:
2855:125385
2852:
2819:
2811:
2785:Nature
2774:
2739:
2732:101247
2729:
2696:
2686:
2653:
2618:
2610:
2580:
2573:316791
2570:
2537:
2529:
2509:Nature
2494:
2486:
2440:
2399:
2358:
2317:
2307:
2268:
2258:
2194:
2184:
2142:
2132:
2086:
2076:
2026:
1971:
1963:
1907:
1866:
1856:
1698:HDAC11
1635:leptin
1589:cilium
1566:enzyme
1564:is an
1520:search
1518:PubMed
1329:Q9Z2V5
1310:Q9UBN7
1206:Entrez
561:BioGPS
140:300272
3699:Types
3464:3.5.5
3447:AICDA
3399:3.5.4
3366:3.5.3
3333:3.5.2
3245:3.5.1
3177:HDAC6
3165:HDAC6
3135:S2CID
2817:S2CID
2689:99970
2616:S2CID
2535:S2CID
2492:S2CID
1969:S2CID
1859:21783
1713:G3BP1
1696:with
1570:HDAC6
1239:15185
1220:10013
1199:Mouse
1194:Human
1165:Amigo
413:Mouse
406:Human
353:Start
288:Mouse
252:Start
185:Human
164:HDAC6
156:31353
123:HDAC6
24:HDAC6
3791:list
3784:EC7
3778:list
3771:EC6
3765:list
3758:EC5
3752:list
3745:EC4
3739:list
3732:EC3
3726:list
3719:EC2
3713:list
3706:EC1
3294:ACY3
3283:ACY1
3238:3.5)
3127:PMID
3090:PMID
3055:PMID
3020:PMID
2991:PMID
2956:PMID
2913:PMID
2860:PMID
2809:PMID
2772:PMID
2737:PMID
2694:PMID
2651:PMID
2608:PMID
2578:PMID
2527:PMID
2484:PMID
2466:Cell
2438:PMID
2397:PMID
2356:PMID
2315:PMID
2266:PMID
2192:PMID
2140:PMID
2116:2011
2084:PMID
2024:PMID
1961:PMID
1905:PMID
1864:PMID
1700:and
1679:and
1646:TAK1
1573:gene
818:axon
396:Bgee
344:Band
305:Chr.
243:Band
202:Chr.
136:OMIM
93:5KH7
89:5EDU
85:3PHD
81:3GV4
77:3C5K
58:RCSB
55:PDBe
3119:doi
3107:447
3080:doi
3045:doi
3041:279
3012:doi
2981:doi
2946:PMC
2938:doi
2903:PMC
2893:doi
2850:PMC
2842:doi
2801:doi
2789:417
2762:doi
2758:277
2727:PMC
2719:doi
2684:PMC
2676:doi
2641:doi
2637:277
2600:doi
2568:PMC
2560:doi
2517:doi
2513:387
2474:doi
2428:doi
2387:doi
2383:277
2346:doi
2342:145
2305:PMC
2297:doi
2256:PMC
2248:doi
2182:PMC
2174:doi
2130:PMC
2120:doi
2074:PMC
2066:doi
2014:doi
2010:282
1951:hdl
1943:doi
1929:via
1895:doi
1854:PMC
1844:doi
366:End
265:End
168:OMA
144:MGI
48:PDB
3831::
3236:EC
3133:.
3125:.
3117:.
3105:.
3088:.
3074:.
3070:.
3053:.
3039:.
3035:.
3018:.
3008:12
3006:.
2989:.
2977:11
2975:.
2971:.
2954:.
2944:.
2934:22
2932:.
2928:.
2911:.
2901:.
2891:.
2881:99
2879:.
2875:.
2858:.
2848:.
2838:21
2836:.
2832:.
2815:.
2807:.
2799:.
2787:.
2770:.
2756:.
2752:.
2735:.
2725:.
2715:30
2713:.
2709:.
2692:.
2682:.
2672:21
2670:.
2666:.
2649:.
2635:.
2631:.
2614:.
2606:.
2596:93
2594:.
2576:.
2566:.
2556:14
2554:.
2550:.
2533:.
2525:.
2511:.
2507:.
2490:.
2482:.
2470:89
2468:.
2464:.
2436:.
2424:23
2422:.
2418:.
2395:.
2381:.
2377:.
2354:.
2340:.
2336:.
2313:.
2303:.
2293:21
2291:.
2287:.
2264:.
2254:.
2244:13
2242:.
2238:.
2213:.
2190:.
2180:.
2170:21
2168:.
2164:.
2152:^
2138:.
2128:.
2114:.
2110:.
2096:^
2082:.
2072:.
2062:27
2060:.
2056:.
2037:.
2022:.
2008:.
2004:.
1967:.
1959:.
1949:.
1939:58
1937:.
1933:.
1917:^
1903:.
1889:.
1885:.
1862:.
1852:.
1842:.
1832:96
1830:.
1826:.
1807:.
1789:.
1760:^
1739:^
1715:.
1704:.
1660:.
1648:.
1595:.
1167:/
372:bp
359:bp
271:bp
258:bp
166:;
162::
158:;
154::
150:;
146::
142:;
138::
91:,
87:,
83:,
79:,
3807::
3793:)
3789:(
3780:)
3776:(
3767:)
3763:(
3754:)
3750:(
3741:)
3737:(
3728:)
3724:(
3715:)
3711:(
3535:e
3528:t
3521:v
3224:e
3217:t
3210:v
3197:.
3184:.
3172:.
3141:.
3121::
3113::
3096:.
3082::
3076:3
3061:.
3047::
3026:.
3014::
2997:.
2983::
2962:.
2940::
2919:.
2895::
2887::
2866:.
2844::
2823:.
2803::
2795::
2778:.
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2743:.
2721::
2700:.
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2657:.
2643::
2622:.
2602::
2584:.
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2541:.
2519::
2498:.
2476::
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2403:.
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2362:.
2348::
2321:.
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2272:.
2250::
2223:.
2198:.
2176::
2146:.
2122::
2090:.
2068::
2030:.
2016::
1989:.
1975:.
1953::
1945::
1911:.
1897::
1891:5
1870:.
1846::
1838::
1811:.
1793:.
290:)
187:)
170::
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