108:
133:
341:
139:
1182:
837:
and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of
917:
Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins".
146:
550:
69:
838:
HERC family genes on chromosome 4. HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.
1251:
1227:
896:
1246:
759:
956:
883:
1064:"The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15"
132:
107:
879:
57:
847:
145:
138:
1220:
1113:"Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B"
972:"Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag"
593:
970:
Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011).
1213:
121:
44:
1158:
81:
723:
678:
1150:
1132:
1093:
1044:
1003:
935:
37:
1197:
1140:
1124:
1083:
1075:
1034:
993:
983:
927:
225:
156:
833:
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a
340:
77:
200:
1145:
1112:
1088:
1063:
998:
971:
484:
479:
474:
469:
464:
459:
454:
449:
433:
428:
423:
407:
402:
397:
392:
387:
382:
1240:
369:
1193:
1162:
218:
98:
1023:"Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein"
1079:
85:
1021:
Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010).
901:
National Center for
Biotechnology Information, U.S. National Library of Medicine
834:
1128:
115:
65:
1136:
1039:
1022:
855:
514:
318:
239:
184:
171:
73:
1154:
1097:
1048:
1007:
988:
939:
931:
48:, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5
802:
791:
636:
622:
579:
460:
regulation of cyclin-dependent protein serine/threonine kinase activity
1111:
Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008).
820:
772:
536:
1181:
499:
495:
1189:
851:
827:
349:
61:
208:
1201:
1062:
Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010).
330:
737:
716:
692:
671:
455:
negative regulation of type I interferon production
875:
873:
871:
155:
16:Protein-coding gene in the species Homo sapiens
912:
910:
1221:
8:
880:GRCh38: Ensembl release 89: ENSG00000138646
1228:
1214:
957:"Entrez Gene: HERC5 hect domain and RLD 5"
817:Probable E3 ubiquitin-protein ligase HERC5
510:
365:
196:
93:
1144:
1087:
1038:
997:
987:
951:
949:
867:
465:regulation of defense response to virus
403:ubiquitin-protein transferase activity
18:
160:
119:
114:
7:
1178:
1176:
1200:. You can help Knowledge (XXG) by
734:
713:
689:
668:
646:
627:
603:
584:
560:
541:
335:
296:
234:
213:
14:
823:that in humans is encoded by the
408:ubiquitin protein ligase activity
1180:
339:
144:
137:
131:
106:
424:perinuclear region of cytoplasm
350:More reference expression data
319:More reference expression data
1:
1252:Human chromosome 4 gene stubs
129:
1123:(13). Switzerland: 2105–17.
1080:10.1016/j.molcel.2010.05.002
1247:Genes on human chromosome 4
1268:
1175:
920:Biochem Biophys Res Commun
480:protein polyubiquitination
383:ISG15 transferase activity
1129:10.1007/s00018-008-8148-5
897:"Human PubMed Reference:"
806:
801:
797:
790:
771:
754:
741:
720:
709:
696:
675:
664:
653:
649:
634:
630:
621:
610:
606:
591:
587:
578:
567:
563:
548:
544:
535:
520:
513:
509:
493:
470:defense response to virus
450:ISG15-protein conjugation
368:
364:
347:
338:
329:
316:
303:
299:
246:
237:
207:
199:
195:
178:
165:
128:
105:
96:
92:
55:
52:
42:
35:
30:
26:
21:
1040:10.4049/jimmunol.0903588
846:HERC5 has been shown to
760:Chr 4: 88.46 – 88.51 Mb
989:10.1186/1742-4690-8-95
932:10.1006/bbrc.1999.1777
485:innate immune response
475:immune system process
278:palpebral conjunctiva
393:transferase activity
122:Chromosome 4 (human)
1117:Cell. Mol. Life Sci
270:germinal epithelium
1188:This article on a
443:Biological process
417:Cellular component
376:Molecular function
1209:
1208:
814:
813:
810:
809:
786:
785:
750:
749:
731:
730:
705:
704:
686:
685:
660:
659:
643:
642:
617:
616:
600:
599:
574:
573:
557:
556:
505:
504:
360:
359:
356:
355:
325:
324:
312:
311:
293:
292:
191:
190:
86:HERC5 - orthologs
1259:
1230:
1223:
1216:
1184:
1177:
1167:
1166:
1148:
1108:
1102:
1101:
1091:
1059:
1053:
1052:
1042:
1018:
1012:
1011:
1001:
991:
967:
961:
960:
953:
944:
943:
914:
905:
904:
893:
887:
877:
799:
798:
782:
767:
762:
745:
735:
726:
714:
710:RefSeq (protein)
700:
690:
681:
669:
647:
628:
604:
585:
561:
542:
511:
366:
352:
343:
336:
321:
297:
242:
240:Top expressed in
235:
214:
197:
187:
174:
163:
148:
141:
135:
124:
110:
94:
88:
47:
40:
19:
1267:
1266:
1262:
1261:
1260:
1258:
1257:
1256:
1237:
1236:
1235:
1234:
1173:
1171:
1170:
1110:
1109:
1105:
1061:
1060:
1056:
1033:(10): 5777–90.
1020:
1019:
1015:
969:
968:
964:
955:
954:
947:
916:
915:
908:
895:
894:
890:
878:
869:
864:
844:
803:View/Edit Human
780:
765:
758:
755:Location (UCSC)
743:
722:
698:
677:
594:ENSG00000138646
489:
438:
412:
388:protein binding
348:
317:
308:
289:
284:
280:
276:
272:
268:
264:
260:
256:
252:
238:
182:
169:
161:
151:
150:
149:
142:
120:
97:Gene location (
56:
43:
36:
17:
12:
11:
5:
1265:
1263:
1255:
1254:
1249:
1239:
1238:
1233:
1232:
1225:
1218:
1210:
1207:
1206:
1185:
1169:
1168:
1103:
1054:
1013:
962:
945:
906:
888:
866:
865:
863:
860:
843:
840:
812:
811:
808:
807:
805:
795:
794:
788:
787:
784:
783:
778:
776:
769:
768:
763:
756:
752:
751:
748:
747:
739:
738:
732:
729:
728:
718:
717:
711:
707:
706:
703:
702:
694:
693:
687:
684:
683:
673:
672:
666:
662:
661:
658:
657:
651:
650:
644:
641:
640:
632:
631:
625:
619:
618:
615:
614:
608:
607:
601:
598:
597:
589:
588:
582:
576:
575:
572:
571:
565:
564:
558:
555:
554:
546:
545:
539:
533:
532:
527:
522:
518:
517:
507:
506:
503:
502:
491:
490:
488:
487:
482:
477:
472:
467:
462:
457:
452:
446:
444:
440:
439:
437:
436:
431:
426:
420:
418:
414:
413:
411:
410:
405:
400:
395:
390:
385:
379:
377:
373:
372:
362:
361:
358:
357:
354:
353:
345:
344:
333:
327:
326:
323:
322:
314:
313:
310:
309:
307:
304:
301:
300:
294:
291:
290:
288:
287:
283:
282:body of uterus
279:
275:
271:
267:
263:
259:
255:
251:
247:
244:
243:
231:
230:
222:
211:
205:
204:
201:RNA expression
193:
192:
189:
188:
180:
176:
175:
167:
164:
159:
153:
152:
143:
136:
130:
126:
125:
118:
112:
111:
103:
102:
90:
89:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1264:
1253:
1250:
1248:
1245:
1244:
1242:
1231:
1226:
1224:
1219:
1217:
1212:
1211:
1205:
1203:
1199:
1195:
1191:
1186:
1183:
1179:
1174:
1164:
1160:
1156:
1152:
1147:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1114:
1107:
1104:
1099:
1095:
1090:
1085:
1081:
1077:
1074:(5): 722–32.
1073:
1069:
1065:
1058:
1055:
1050:
1046:
1041:
1036:
1032:
1028:
1024:
1017:
1014:
1009:
1005:
1000:
995:
990:
985:
981:
977:
976:Retrovirology
973:
966:
963:
958:
952:
950:
946:
941:
937:
933:
929:
926:(1): 115–22.
925:
921:
913:
911:
907:
902:
898:
892:
889:
885:
881:
876:
874:
872:
868:
861:
859:
857:
853:
849:
841:
839:
836:
831:
829:
826:
822:
818:
804:
800:
796:
793:
789:
779:
777:
774:
770:
764:
761:
757:
753:
746:
740:
736:
733:
727:
725:
719:
715:
712:
708:
701:
695:
691:
688:
682:
680:
674:
670:
667:
665:RefSeq (mRNA)
663:
656:
652:
648:
645:
639:
638:
633:
629:
626:
624:
620:
613:
609:
605:
602:
596:
595:
590:
586:
583:
581:
577:
570:
566:
562:
559:
553:
552:
547:
543:
540:
538:
534:
531:
528:
526:
523:
519:
516:
512:
508:
501:
497:
492:
486:
483:
481:
478:
476:
473:
471:
468:
466:
463:
461:
458:
456:
453:
451:
448:
447:
445:
442:
441:
435:
432:
430:
427:
425:
422:
421:
419:
416:
415:
409:
406:
404:
401:
399:
396:
394:
391:
389:
386:
384:
381:
380:
378:
375:
374:
371:
370:Gene ontology
367:
363:
351:
346:
342:
337:
334:
332:
328:
320:
315:
305:
302:
298:
295:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
248:
245:
241:
236:
233:
232:
229:
227:
223:
221:
220:
216:
215:
212:
210:
206:
202:
198:
194:
186:
181:
177:
173:
168:
158:
154:
147:
140:
134:
127:
123:
117:
113:
109:
104:
100:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1202:expanding it
1194:chromosome 4
1187:
1172:
1120:
1116:
1106:
1071:
1067:
1057:
1030:
1026:
1016:
979:
975:
965:
923:
919:
900:
891:
845:
842:Interactions
832:
824:
816:
815:
742:
721:
697:
676:
654:
635:
611:
592:
568:
549:
529:
524:
258:right testis
224:
217:
53:External IDs
835:HECT domain
398:RNA binding
266:left testis
183:88,506,163
170:88,457,119
31:Identifiers
1241:Categories
886:, May 2017
862:References
286:left ovary
228:(ortholog)
66:HomoloGene
1192:on human
1137:1420-682X
1027:J Immunol
856:Cyclin E1
724:NP_057407
679:NM_016323
515:Orthologs
434:cytoplasm
74:GeneCards
1155:18535780
1146:11131906
1098:20542004
1068:Mol Cell
1049:20385878
1008:22093708
940:10581175
882:–
848:interact
792:Wikidata
494:Sources:
274:monocyte
254:testicle
1163:6897759
1089:2887317
999:3228677
884:Ensembl
623:UniProt
580:Ensembl
521:Species
500:QuickGO
429:cytosol
203:pattern
38:Aliases
1161:
1153:
1143:
1135:
1096:
1086:
1047:
1006:
996:
982:: 95.
938:
821:enzyme
819:is an
775:search
773:PubMed
637:Q9UII4
537:Entrez
331:BioGPS
162:4q22.1
62:608242
1196:is a
1159:S2CID
850:with
825:HERC5
551:51191
530:Mouse
525:Human
496:Amigo
262:sperm
250:gonad
226:Mouse
219:Human
166:Start
99:Human
78:HERC5
70:81848
45:HERC5
22:HERC5
1198:stub
1190:gene
1151:PMID
1133:ISSN
1094:PMID
1045:PMID
1004:PMID
936:PMID
854:and
852:NME2
828:gene
209:Bgee
157:Band
116:Chr.
58:OMIM
1141:PMC
1125:doi
1084:PMC
1076:doi
1035:doi
1031:184
994:PMC
984:doi
928:doi
924:266
781:n/a
766:n/a
744:n/a
699:n/a
655:n/a
612:n/a
569:n/a
306:n/a
179:End
82:OMA
1243::
1157:.
1149:.
1139:.
1131:.
1121:65
1119:.
1115:.
1092:.
1082:.
1072:38
1070:.
1066:.
1043:.
1029:.
1025:.
1002:.
992:.
978:.
974:.
948:^
934:.
922:.
909:^
899:.
870:^
858:.
830:.
498:/
185:bp
172:bp
80:;
76::
72:;
68::
64:;
60::
1229:e
1222:t
1215:v
1204:.
1165:.
1127::
1100:.
1078::
1051:.
1037::
1010:.
986::
980:8
959:.
942:.
930::
903:.
101:)
84::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
