1362:
1465:(mAKAP) organized E3 ubiquitin ligases, affecting stability and positioning of HIF-1 inside its action site in the nucleus. Depletion of mAKAP or disruption of its targeting to the perinuclear (in cardiomyocytes) region altered the stability of HIF-1 and transcriptional activation of genes associated with hypoxia. Thus, "compartmentalization" of oxygen-sensitive signaling components may influence the hypoxic response.
1568:(liver failure), however it is unclear whether this death was actually caused by FG-2216. The hold on further testing of FG-4592 was lifted in early 2008, after the FDA reviewed and approved a thorough response from FibroGen. Roxadustat, vadadustat, daprodustat and molidustat have now all progressed through to Phase III clinical trials for treatment of renal anemia.
1001:
890:
4008:
Debenham JS, Madsen-Duggan C, Clements MJ, Walsh TF, Kuethe JT, Reibarkh M, et al. (December 2016). "Discovery of N--4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of
Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of
1365:
Nobel Prize in
Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. It then associates with VHL and is tagged with ubiquitin resulting in proteasomal degradation. Under hypoxic conditions, Hif-1
1506:
demonstrated that HIF1A activation was able to prevent and treat chronic wounds in diabetic and aged mice. Not only did the wounds in the mice heal more quickly, but the quality of the new skin was even better than the original. Additionally the regenerative effect of HIF-1A modulation on aged skin
1576:
In other scenarios and in contrast to the therapy outlined above, research suggests that HIF induction in normoxia is likely to have serious consequences in disease settings with a chronic inflammatory component. It has also been shown that chronic inflammation is self-perpetuating and that it
1501:
hydroxylases (PHDs). In June 2015, scientists found that the continued up-regulation of HIF-1a via PHD inhibitors regenerates lost or damaged tissue in mammals that have a repair response; and the continued down-regulation of Hif-1a results in healing with a scarring response in mammals with a
1366:
alpha translocates to the cell nucleus and associates with Hif-1 beta. This complex then binds to the HRE region of the DNA resulting in the transcription of genes that are involved in a multitude of processes including erythropoesis, glycolysis, and angiogenesis.
1507:
cells was described and a rejuvenating effect on aged facial skin was demonstrated in patients. HIF modulation has also been linked to a beneficial effect on hair loss. The biotech company
Tomorrowlabs GmbH, founded in Vienna in 2016 by the physician
1502:
previous regenerative response to the loss of tissue. The act of regulating HIF-1a can either turn off, or turn on the key process of mammalian regeneration. One such regenerative process in which HIF1A is involved is skin healing. Researchers at the
1481:(small interfering RNA) studies for individual NF-κB members revealed differential effects on HIF-1α mRNA levels, indicating that NF-κB can regulate basal HIF-1α expression. Finally, it was shown that, when endogenous NF-κB is induced by
4079:
Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, et al. (May 2016). "Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor".
5541:
1468:
The advanced knowledge of the molecular regulatory mechanisms of HIF1 activity under hypoxic conditions contrast sharply with the paucity of information on the mechanistic and functional aspects governing
5534:
2374:
Srikanth L, Sunitha MM, Venkatesh K, Kumar PS, Chandrasekhar C, Vengamma B, et al. (2015). "Anaerobic
Glycolysis and HIF1α Expression in Haematopoietic Stem Cells Explains Its Quiescence Nature".
1556:. Other significant compounds from this family, which are used in research but have not been developed for medical use in humans, include MK-8617, YC-1, IOX-2, 2-methoxyestradiol, GN-44028, AKB-4924,
2615:
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. (May 1999). "The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis".
1515:, makes use of this mechanism. Based on the patent-pending HSF ("HIF strengthening factor") active ingredient, products have been developed that are supposed to promote skin and hair regeneration.
1564:. Both FibroGen compounds made it through to Phase II clinical trials, but these were suspended temporarily in May 2007 following the death of a trial participant taking FG-2216 from fulminant
6463:
3538:
10953:
5527:
4518:
Salminen A, Kaarniranta K, Kauppinen A (August 2016). "AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms".
3871:"Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers"
5175:
Adamcio B, Sperling S, Hagemeyer N, Walkinshaw G, Ehrenreich H (March 2010). "Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice".
6962:
3264:
Duscher D, Trotsyuk AA, Maan ZN, Kwon SH, Rodrigues M, Engel K, et al. (August 2019). "Optimization of transdermal deferoxamine leads to enhanced efficacy in healing skin wounds".
1593:
and cancer. Therefore, it is thought that understanding the cross-talk between these two key transcription factors, NF-κB and HIF, will greatly enhance the process of drug development.
1581:. As a consequence, alterations in growth factor, chemokine, cytokine, and ROS balance occur within the cellular milieu that in turn provide the axis of growth and survival needed for
11003:
816:
for their work in elucidating the role of HIF-1 in oxygen sensing and its role in surviving low oxygen conditions. In 2019, the same three individuals were jointly awarded the
1560:, FG-2216 and FG-4497. By inhibiting prolyl-hydroxylase enzyme, the stability of HIF-2α in the kidney is increased, which results in an increase in endogenous production of
9169:
1473:-mediated HIF1 regulation under normoxic conditions. However, HIF-1α stabilization is also found in non-hypoxic conditions through an unknown mechanism. It was shown that
7847:
6869:
6864:
6859:
1100:
957:
3380:
Pagani A, Kirsch BM, Hopfner U, Aitzetmueller MM, Brett EA, Thor D, et al. (June 2020). "Deferiprone
Stimulates Aged Dermal Fibroblasts Via HIF-1α Modulation".
6508:
6493:
6179:
3614:
1485:(tumour necrosis factor α) treatment, HIF-1α levels also change in an NF-κB-dependent manner. HIF-1 and HIF-2 have different physiological roles. HIF-2 regulates
1208:
837:
191:
176:
3639:
Bruegge K, Jelkmann W, Metzen E (2007). "Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases".
645:
504:
355:
206:
57:
7002:
4391:"HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques"
3589:
10797:
10781:
5600:
5451:
3822:"Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia"
6854:
10993:
6639:
6632:
6627:
6615:
6610:
6605:
6600:
6595:
6523:
4217:"A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection"
10519:
4044:
Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, Kim MS, et al. (April 2003). "YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1".
1341:
In general, HIFs are vital to development. In mammals, deletion of the HIF-1 genes results in perinatal death. HIF-1 has been shown to be vital to
7318:
1397:. This occurs only in normoxic conditions. In hypoxic conditions, HIF prolyl-hydroxylase is inhibited, since it utilizes oxygen as a cosubstrate.
5403:
4851:"Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and its related clinical significance"
6377:
3978:
1503:
1307:
for being metabolically maintaining at a low rate so as to preserve the potency of stem cells for long periods in a life cycle of an organism.
3920:"Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects"
1310:
The HIF signaling cascade mediates the effects of hypoxia, the state of low oxygen concentration, on the cell. Hypoxia often keeps cells from
10988:
10973:
2008:
1451:
1048:
817:
10983:
10978:
4307:"Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis"
4438:
10282:
6174:
5746:
669:
528:
379:
230:
81:
10551:
9450:
7537:
1428:
2509:"Fibroblast-Specific Deletion of Hypoxia Inducible Factor-1 Critically Impairs Murine Cutaneous Neovascularization and Wound Healing"
2460:"Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing"
6995:
6990:
6918:
6908:
5785:
5775:
5610:
1419:
HIF-1, when stabilized by hypoxic conditions, upregulates several genes to promote survival in low-oxygen conditions. These include
848:(bHLH) family of transcription factors. The alpha and beta subunit are similar in structure and both contain the following domains:
5498:
provides an overview of all the structure information available in the PDB for Human Aryl hydrocarbon receptor nuclear translocator
6913:
6827:
3417:"A single-center blinded randomized clinical trial to evaluate the anti-aging effects of a novel HSF-based skin care formulation"
1617:
1529:
657:
516:
367:
218:
69:
5504:
provides an overview of all the structure information available in the PDB for Human
Endothelial PAS domain-containing protein 1
9849:
7125:
7115:
5716:
5595:
650:
3778:"Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease"
1361:
509:
360:
62:
10998:
7480:
7120:
6815:
211:
2117:
Zhulin IB, Taylor BL, Dixon R (September 1997). "PAS domain S-boxes in
Archaea, Bacteria and sensors for oxygen and redox".
1652:
1120:
977:
5318:"Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis"
10762:
10757:
9908:
6820:
5373:
3563:
1338:. It is therefore not surprising that HIF-1 modulation was identified as a promising treatment paradigm in wound healing.
5269:"Effect of hypoxia-inducible factor-1/vascular endothelial growth factor signaling pathway on spinal cord injury in rats"
2032:
10857:
9193:
7343:
6896:
6886:
1439:
that contain the sequence 5'-RCGTG-3' (where R is a purine, either A or G). Studies demonstrate that hypoxia modulates
9362:
9357:
8908:
6985:
6903:
6891:
5967:
5510:
provides an overview of all the structure information available in the PDB for Human
Hypoxia-inducible factor 3-alpha
5492:
provides an overview of all the structure information available in the PDB for Human
Hypoxia-inducible factor 1-alpha
1991:
Acker T, Plate KH (2004). "Hypoxia and
Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiology".
4266:"Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking"
7098:
6096:
10514:
7395:
7380:
7363:
7358:
7353:
7348:
7259:
7234:
7110:
7022:
7012:
6169:
5642:
5220:"HIF-1α Activation Attenuates IL-6 and TNF-α Pathways in Hippocampus of Rats Following Transient Global Ischemia"
1585:
development of cancer and metastasis. These results have numerous implications for a number of pathologies where
1412:
genes can cause a build-up of succinate that inhibits HIF prolyl-hydroxylase, stabilizing HIF-1α. This is termed
1346:
869:
2667:
2556:
Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, et al. (July 2010).
10256:
9891:
9407:
8980:
8819:
7754:
7749:
7734:
7209:
7184:
7066:
7017:
6810:
5667:
5483:
1601:
1311:
1300:
4346:
Silva PL, Rocco PR, Pelosi P (August 2015). "FG-4497: a new target for acute respiratory distress syndrome?".
1108:
965:
10621:
8662:
7979:
7093:
7081:
5430:"Merck Receives Priority Review From FDA for New Drug Application for HIF-2α Inhibitor Belzutifan (MK-6482)"
4215:
Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, et al. (September 2012).
1401:
829:
2736:
10752:
8799:
8794:
7189:
7086:
6881:
6842:
5905:
5554:
4703:
3307:
Bonham CA, Rodrigues M, Galvez M, Trotsyuk A, Stern-Buchbinder Z, Inayathullah M, et al. (May 2018).
1477:(nuclear factor κB) is a direct modulator of HIF-1α expression in the presence of normal oxygen pressure.
1424:
845:
785:
662:
521:
4439:"The FDA Accepts the Complete Response for Clinical Holds of FG-2216/FG-4592 for the Treatment of Anemia"
2153:
1934:"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension"
372:
74:
10744:
10304:
7103:
7039:
7034:
6847:
5923:
5316:
Choueiri TK, Bauer TM, Papadopoulos KP, Plimack ER, Merchan JR, McDermott DF, et al. (April 2021).
2818:
Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, et al. (March 2019).
769:
715:
223:
127:
1104:
961:
5479:
10325:
10317:
8155:
7637:
7162:
7157:
7152:
6832:
6715:
5550:
4958:
4089:
3931:
3218:
2888:
2831:
2774:
2624:
2569:
2328:
2271:
2165:
1945:
1656:
1590:
1578:
1508:
1061:
574:
425:
276:
5519:
4849:
Ezzeddini R, Taghikhani M, Salek Farrokhi A, Somi MH, Samadi N, Esfahani A, et al. (May 2021).
3081:
10639:
10343:
10039:
8242:
7447:
7029:
7007:
6980:
6942:
6876:
1390:
5044:"In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study"
1512:
820:
for their work in elucidating how HIF senses and adapts cellular response to oxygen availability.
10177:
5355:
5249:
5200:
5157:
5024:
5016:
4878:
4731:
4610:
Cummins EP, Keogh CE, Crean D, Taylor CT (2016). "The role of HIF in immunity and inflammation".
4543:
4371:
4113:
3851:
3755:
3703:
3495:
3466:"Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms"
3446:
3289:
3205:
Duscher D, Neofytou E, Wong VW, Maan ZN, Rennert RC, Inayathullah M, et al. (January 2015).
2912:
2800:
2717:
2648:
2440:
2297:
2240:
2191:
2099:
2050:
1911:
1637:
1557:
1455:
1436:
805:
801:
3869:
Kansagra KA, Parmar D, Jani RH, Srinivas NR, Lickliter J, Patel HV, et al. (January 2018).
3107:
Zhang Y, Strehin I, Bedelbaeva K, Gourevitch D, Clark L, Leferovich J, et al. (June 2015).
4751:"Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer"
4131:
Wang R, Zhou S, Li S (2011). "Cancer therapeutic agents targeting hypoxia-inducible factor-1".
9759:
9750:
9387:
8335:
7076:
7071:
5347:
5298:
5241:
5192:
5149:
5108:
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4986:
4927:
4870:
4831:
4782:
4723:
4684:
4633:
4592:
4535:
4500:
4445:
4420:
4363:
4328:
4287:
4264:
Görtz GE, Horstmann M, Aniol B, Reyes BD, Fandrey J, Eckstein A, et al. (December 2016).
4246:
4197:
4148:
4105:
4061:
4026:
3990:
3959:
3900:
3843:
3799:
3747:
3695:
3656:
3487:
3438:
3397:
3338:
3281:
3246:
3187:
3138:
3062:
3013:
2961:
2904:
2857:
2792:
2709:
2640:
2597:
2538:
2489:
2432:
2383:
2356:
2289:
2232:
2183:
2134:
2091:
2014:
2004:
1973:
1903:
1862:
1844:
1803:
1795:
1756:
1707:
1282:
1265:
1248:
1231:
1197:
1127:
1095:
952:
777:
9570:
9565:
9560:
9555:
9550:
1214:
8642:
8286:
8268:
6837:
6784:
6558:
5429:
5337:
5329:
5288:
5280:
5231:
5184:
5139:
5100:
5063:
5055:
4997:
4976:
4966:
4917:
4909:
4862:
4821:
4813:
4772:
4762:
4715:
4674:
4664:
4623:
4615:
4582:
4574:
4527:
4490:
4482:
4410:
4402:
4389:
Hsieh MM, Linde NS, Wynter A, Metzger M, Wong C, Langsetmo I, et al. (September 2007).
4355:
4318:
4277:
4236:
4228:
4187:
4179:
4168:"Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors"
4140:
4097:
4053:
4018:
3949:
3939:
3890:
3882:
3833:
3789:
3737:
3687:
3648:
3477:
3428:
3389:
3328:
3320:
3273:
3236:
3226:
3177:
3169:
3128:
3120:
3052:
3044:
3003:
2995:
2951:
2943:
2896:
2847:
2839:
2782:
2701:
2632:
2587:
2577:
2528:
2520:
2479:
2471:
2422:
2414:
2346:
2336:
2279:
2222:
2173:
2126:
2081:
1996:
1963:
1953:
1893:
1852:
1834:
1787:
1746:
1738:
1697:
1689:
809:
797:
710:
569:
420:
271:
122:
9730:
9725:
9675:
9665:
9645:
9630:
9610:
9535:
9515:
8657:
8652:
3820:
Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M, et al. (December 2017).
2692:
Semenza GL (August 2004). "Hydroxylation of HIF-1: oxygen sensing at the molecular level".
2507:
Duscher D, Maan ZN, Whittam AJ, Sorkin M, Hu MS, Walmsley GG, et al. (November 2015).
1087:
944:
10427:
9650:
9520:
8886:
8844:
8839:
8834:
8772:
8684:
8606:
8394:
8345:
8340:
6387:
4704:"Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma"
2458:
Duscher D, Januszyk M, Maan ZN, Whittam AJ, Hu MS, Walmsley GG, et al. (March 2017).
1629:
1319:
739:
719:
598:
449:
300:
151:
131:
2070:"Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1"
578:
429:
280:
4962:
4653:"Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis"
4093:
3935:
3222:
2892:
2835:
2778:
2628:
2573:
2427:
2402:
2332:
2315:
Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, et al. (April 2002).
2275:
2169:
1949:
10524:
8804:
8787:
6930:
6585:
5582:
5452:"FDA Grants Priority Review to Belzutifan for von Hippel-Lindau Disease–Associated RCC"
5342:
5317:
5293:
5268:
5068:
5043:
4981:
4922:
4897:
4826:
4801:
4777:
4750:
4679:
4587:
4562:
4495:
4471:"Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases"
4470:
4415:
4390:
4241:
4216:
4192:
4167:
3954:
3895:
3870:
3333:
3308:
3241:
3182:
3157:
3133:
3108:
3057:
3032:
3008:
2983:
2956:
2931:
2852:
2592:
2533:
2508:
2484:
2459:
1857:
1822:
1751:
1726:
1702:
1677:
1625:
1561:
1486:
1383:
5516:
visualises the crystal structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA
3675:
3356:
2876:
2351:
2209:
Yang J, Zhang L, Erbel PJ, Gardner KH, Ding K, Garcia JA, et al. (October 2005).
2178:
2130:
10967:
9382:
8722:
7147:
6935:
6263:
5507:
5501:
5495:
5489:
5359:
4882:
3499:
3450:
3293:
3156:
Hong WX, Hu MS, Esquivel M, Liang GY, Rennert RC, McArdle A, et al. (May 2014).
2820:"Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate"
1968:
1693:
1651:
is an hypoxia-inducible factor-2α inhibitor under investigation for the treatment of
1552:(Bay 85-3934), all of which are intended as orally acting drugs for the treatment of
1053:
836:
composed of an alpha and a beta subunit, the latter being a constitutively-expressed
784:, such as thiamine deficiency. Both hypoxia and pseudohypoxia leads to impairment of
781:
5253:
5204:
5161:
4735:
4117:
3855:
3726:"A New Approach to the Management of Anemia in CKD Patients: A Review on Roxadustat"
3464:
Houschyar KS, Borrelli MR, Tapking C, Popp D, Puladi B, Ooms M, et al. (2020).
2916:
2804:
2444:
2301:
2244:
2195:
2103:
1915:
1029:
918:
10932:
10244:
10127:
10119:
9490:
9446:
8449:
8297:
5042:
Syed Alwi SS, Cavell BE, Telang U, Morris ME, Parry BM, Packham G (November 2010).
4547:
4375:
3759:
2721:
2652:
2260:"Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling"
1597:
1432:
1371:
1331:
1315:
1083:
940:
813:
5144:
5127:
5091:
Semenza GL (October 2007). "Evaluation of HIF-1 inhibitors as anticancer agents".
4359:
3707:
3277:
2317:"Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha"
5104:
4406:
4022:
3944:
3919:
3676:"HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond"
3124:
2524:
2475:
2000:
1041:
686:
545:
396:
247:
98:
10616:
10219:
8699:
8414:
8379:
6768:
6573:
6568:
6011:
5815:
5810:
5706:
5586:
3048:
1791:
1621:
1605:
1541:
1443:
1342:
833:
749:
608:
459:
310:
161:
5381:
5333:
4951:
Proceedings of the National Academy of Sciences of the United States of America
4866:
4144:
3794:
3777:
3652:
3211:
Proceedings of the National Academy of Sciences of the United States of America
2763:"Hypoxia induces rapid changes to histone methylation and reprograms chromatin"
2705:
2562:
Proceedings of the National Academy of Sciences of the United States of America
2321:
Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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4802:"Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?"
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3309:"Deferoxamine can prevent pressure ulcers and accelerate healing in aged mice"
3082:"Scientist at LIMR leads study demonstrating drug-induced tissue regeneration"
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4947:"Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization"
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Pergola PE, Spinowitz BS, Hartman CS, Maroni BJ, Haase VH (November 2016).
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2018:
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5013:. If this is an intentional citation to a retracted paper, please replace
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2930:
Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD (December 2008).
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survival, allowing the cells to adapt to low-oxygen conditions within the
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3539:"Kosmetikbranche: Wie das Beauty-Start-up Tomorrowlabs den Markt erobert"
2761:
Batie M, Frost J, Frost M, Wilson JW, Schofield P, Rocha S (March 2019).
1586:
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557:
408:
259:
110:
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Chen H, Li J, Liang S, Lin B, Peng Q, Zhao P, et al. (March 2017).
2258:
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (June 2002).
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10649:
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4913:
4563:"Hypoxia-dependent regulation of inflammatory pathways in immune cells"
3918:
Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U (2014).
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2999:
2211:"Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor"
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Ezzeddini R, Taghikhani M, Somi MH, Samadi N, Rasaee, MJ (May 2019).
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3207:"Transdermal deferoxamine prevents pressure-induced diabetic ulcers"
4945:
Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL (October 2009).
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2636:
1776:"HIF1-α-mediated gene expression induced by vitamin B1 deficiency"
1616:
Research conducted on mice suggests that stabilizing HIF using an
1478:
1379:
1353:. HIF plays a central role in the regulation of human metabolism.
1327:
1276:
1259:
1242:
1225:
1191:
638:
623:
489:
474:
340:
325:
50:
35:
1995:. Cancer Treatment and Research. Vol. 117. pp. 219–48.
1882:"Purification and characterization of hypoxia-inducible factor 1"
1435:. HIF-1 acts by binding to hypoxia-responsive elements (HREs) in
10921:
10916:
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5635:
5630:
5625:
5620:
5615:
5605:
3590:"Milliardenmarkt Anti-Aging: Start-up aus Österreich mischt mit"
2932:"mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha"
1462:
1409:
1405:
1350:
1077:
1024:
934:
913:
674:
533:
384:
235:
86:
10692:
10021:
8263:
6763:
5565:
5523:
3514:
1577:
distorts the microenvironment as a result of aberrantly active
10563:
10192:
10182:
10062:
9458:
9015:
8364:
7815:
7552:
7046:
6518:
6347:
6337:
6332:
6124:
6119:
4166:
Minegishi H, Fukashiro S, Ban HS, Nakamura H (February 2013).
3979:"The latest advances in kidney diseases and related disorders"
1725:
Wilkins SE, Abboud MI, Hancock RL, Schofield CJ (April 2016).
1608:
are (since 2006) under investigation for anti-cancer effects.
1387:
4749:
Singh D, Arora R, Kaur P, Singh B, Mannan R, Arora S (2017).
4561:
Taylor CT, Doherty G, Fallon PG, Cummins EP (October 2016).
2984:"Regulation of hypoxia-inducible factor-1alpha by NF-kappaB"
2558:"Regulation of human metabolism by hypoxia-inducible factor"
1600:
required for cancer tumor growth, so HIF inhibitors such as
5404:"MHRA awards first 'innovation passport' under new pathway"
1628:
expression. HIF pathway activators such as ML-228 may have
1497:
In normal circumstances after injury HIF-1a is degraded by
5128:"Inhibiting hypoxia-inducible factor 1 for cancer therapy"
3033:"Hypoxic regulation of erythropoiesis and iron metabolism"
1727:"Targeting Protein-Protein Interactions in the HIF System"
1450:. This paper was published back-to-back with that of 2019
796:
The HIF transcriptional complex was discovered in 1995 by
3826:
The Journal of Pharmacology and Experimental Therapeutics
2068:
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL (July 1996).
1644:
von Hippel–Lindau disease-associated renal cell carcinoma
3615:"Ein Protein gegen das Altern und für das Geldverdienen"
1780:
International Journal for Vitamin and Nutrition Research
3158:"The Role of Hypoxia-Inducible Factor in Wound Healing"
1458:
This work was highlighted in an independent editorial.
1005:
Structure of hypoxia-inducible factor-1 alpha subunit.
4469:
Eltzschig HK, Bratton DL, Colgan SP (November 2014).
2154:"PAS: a multifunctional domain family comes to light"
1532:
have been developed. The most notable compounds are:
894:
Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex.
4270:
The Journal of Clinical Endocrinology and Metabolism
3564:"Das neue Beauty-Investment von Michael Pieper - HZ"
2033:"Oxygen sensing – an essential process for survival"
10811:
10771:
10740:
10705:
10630:
10607:
10589:
10339:
10313:
10265:
10168:
10115:
10035:
9969:
9786:
9746:
9442:
9259:
8899:
8625:
8313:
8294:
8282:
8233:
8146:
8125:
7327:
7247:
7218:
7198:
7173:
7136:
7055:
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6799:
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6706:
6651:
6549:
6459:
6435:
6358:
6291:
6155:
6105:
5914:
5900:
5578:
3415:Duscher D, Maan ZN, Hu MS, Thor D (November 2020).
1932:Wang GL, Jiang BH, Rue EA, Semenza GL (June 1995).
1823:"Hiding in Plain Sight: Modern Thiamine Deficiency"
1174:The following are members of the human HIF family:
1126:
1114:
1094:
1076:
1071:
1047:
1035:
1023:
1015:
1010:
993:
971:
951:
933:
928:
912:
904:
899:
882:
745:
735:
730:
709:
704:
692:
680:
668:
656:
644:
634:
629:
622:
604:
594:
589:
568:
563:
551:
539:
527:
515:
503:
495:
485:
480:
473:
455:
445:
440:
419:
414:
402:
390:
378:
366:
354:
346:
336:
331:
324:
306:
296:
291:
270:
265:
253:
241:
229:
217:
205:
197:
187:
182:
175:
157:
147:
142:
121:
116:
104:
92:
80:
68:
56:
46:
41:
34:
4896:D'Ignazio L, Bandarra D, Rocha S (February 2016).
2051:"How cells sense and adapt to oxygen availability"
862:(PAS) domain, which facilitates heterodimerization
2057:. NobelPrize.org. Nobel Media AB. 7 October 2019.
1393:, which labels them for rapid degradation by the
1288:aryl-hydrocarbon receptor nuclear translocator 3
1254:aryl-hydrocarbon receptor nuclear translocator 2
3088:. Lankenau Institute for Medical Research (LIMR)
3037:American Journal of Physiology. Renal Physiology
1632:and are of interest as potential treatments for
475:aryl-hydrocarbon receptor nuclear translocator 2
4305:Beuck S, Schänzer W, Thevis M (November 2012).
3771:
3769:
2977:
2975:
1676:Smith TG, Robbins PA, Ratcliffe PJ (May 2008).
1427:synthesis in an oxygen-independent manner, and
1220:aryl hydrocarbon receptor nuclear translocator
11004:World Anti-Doping Agency prohibited substances
3815:
3813:
3719:
3717:
2055:The Nobel Prize in Physiology or Medicine 2019
838:aryl hydrocarbon receptor nuclear translocator
177:aryl hydrocarbon receptor nuclear translocator
10954:transcription factor/coregulator deficiencies
10025:β-Scaffold factors with minor groove contacts
5535:
4898:"NF-κB and HIF crosstalk in immune responses"
4800:Huang Y, Lin D, Taniguchi CM (October 2017).
2982:van Uden P, Kenneth NS, Rocha S (June 2008).
2401:Benizri E, Ginouvès A, Berra E (April 2008).
1927:
1925:
994:HIF-1 alpha C terminal transactivation domain
800:and postdoctoral fellow Guang Wang. In 2016,
8:
2403:"The magic of the hypoxia-signaling cascade"
1678:"The human side of hypoxia-inducible factor"
10702:
10689:
10032:
10018:
8310:
8291:
8279:
8260:
6796:
6777:
6760:
5911:
5575:
5562:
5542:
5528:
5520:
5027:|...|intentional=yes}}
2039:. Albert And Mary Lasker Foundation. 2016.
2037:Albert Lasker Basic Medical Research Award
1318:, and is important for the formation of a
1271:hypoxia inducible factor 3, alpha subunit
1203:hypoxia-inducible factor 1, alpha subunit
1068:
999:
925:
888:
832:transcriptional complex HIF-1, which is a
727:
586:
437:
288:
139:
5482:at the U.S. National Library of Medicine
5341:
5292:
5235:
5143:
5067:
4980:
4970:
4921:
4825:
4776:
4766:
4678:
4668:
4627:
4586:
4494:
4414:
4322:
4281:
4240:
4191:
3953:
3943:
3894:
3837:
3793:
3741:
3481:
3432:
3332:
3240:
3230:
3181:
3132:
3109:"Drug-induced regeneration in adult mice"
3056:
3007:
2955:
2851:
2786:
2591:
2581:
2532:
2483:
2426:
2350:
2340:
2283:
2226:
2177:
2085:
1967:
1957:
1897:
1856:
1838:
1750:
1701:
624:hypoxia-inducible factor 3, alpha subunit
36:hypoxia-inducible factor 1, alpha subunit
4046:Journal of the National Cancer Institute
1360:
1176:
3357:"duscher hif - Search Results - PubMed"
2152:Ponting CP, Aravind L (November 1997).
1668:
1400:Inhibition of electron transfer in the
772:that respond to decreases in available
4855:Journal of Physiology and Biochemistry
2877:"Histone modifiers are oxygen sensors"
1504:Stanford University School of Medicine
990:
879:
788:(ATP) production by the mitochondria.
619:
470:
321:
172:
31:
5432:(Press release). Merck. 16 March 2016
5273:Experimental and Therapeutic Medicine
4567:The Journal of Clinical Investigation
4348:Expert Review of Respiratory Medicine
3674:Maxwell PH, Eckardt KU (March 2016).
2875:Gallipoli P, Huntly BJ (March 2019).
1589:and HIF-1 are deregulated, including
1493:Repair, regeneration and rejuvenation
1452:Nobel Prize in Physiology or Medicine
828:Oxygen-breathing species express the
818:Nobel Prize in Physiology or Medicine
7:
5224:Cellular Physiology and Biochemistry
3080:eurekalert.org staff (3 June 2015).
2407:Cellular and Molecular Life Sciences
1880:Wang GL, Semenza GL (January 1995).
1528:Several drugs that act as selective
780:. They also respond to instances of
6708:(1.6) Basic helix-span-helix (bHSH)
2215:The Journal of Biological Chemistry
2074:The Journal of Biological Chemistry
1886:The Journal of Biological Chemistry
27:Protein that responds to low oxygen
2668:"Seeking a Cellular Oxygen Sensor"
2513:Plastic and Reconstructive Surgery
2464:Plastic and Reconstructive Surgery
1429:vascular endothelial growth factor
1303:explains the quiescence nature of
25:
5378:SPS - Specialist Pharmacy Service
1530:HIF prolyl-hydroxylase inhibitors
1382:, allowing their recognition and
1237:endothelial PAS domain protein 1
10994:Developmental genes and proteins
5048:The British Journal of Nutrition
1694:10.1111/j.1365-2141.2008.07029.x
1618:HIF prolyl-hydroxylase inhibitor
1404:complex due to mutations in the
1314:. However, hypoxia promotes the
776:in the cellular environment, or
326:endothelial PAS domain protein 1
10695:(0) Other transcription factors
9979:transcriptional enhancer factor
5596:Activating transcription factor
5380:. 18 March 2021. Archived from
4172:ACS Medicinal Chemistry Letters
3724:Becker K, Saad M (April 2017).
3588:andrea.hodoschek (2020-08-03).
3421:Journal of Cosmetic Dermatology
1330:also promotes the migration of
855:– a bHLH domain for DNA binding
4475:Nature Reviews. Drug Discovery
4011:Journal of Medicinal Chemistry
3113:Science Translational Medicine
2119:Trends in Biochemical Sciences
1682:British Journal of Haematology
1461:It has been shown that muscle
1370:The alpha subunits of HIF are
1:
9909:Interferon regulatory factors
8148:(2.5) Alternating composition
7344:General transcription factors
5145:10.1158/1541-7786.MCR-06-0235
4612:Molecular Aspects of Medicine
4360:10.1586/17476348.2015.1065181
4221:Journal of Molecular Medicine
3313:Wound Repair and Regeneration
3278:10.1016/j.jconrel.2019.07.009
3266:Journal of Controlled Release
2179:10.1016/S0960-9822(06)00352-6
2131:10.1016/S0968-0004(97)01110-9
1624:memory, likely by increasing
1072:Available protein structures:
929:Available protein structures:
840:(ARNT). HIF-1 belongs to the
10989:Genes on human chromosome 19
10974:Genes on human chromosome 14
9194:Octamer transcription factor
5902:(1.2) Basic helix-loop-helix
5126:Melillo G (September 2006).
5105:10.1016/j.drudis.2007.08.006
4407:10.1182/blood-2007-02-073254
4023:10.1021/acs.jmedchem.6b01242
3983:Drug News & Perspectives
3945:10.1371/journal.pone.0111838
3125:10.1126/scitranslmed.3010228
2737:"Discovering HIF Regulation"
2525:10.1097/PRS.0000000000001699
2476:10.1097/PRS.0000000000003072
2001:10.1007/978-1-4419-8871-3_14
1993:Angiogenesis in Brain Tumors
1596:HIF activity is involved in
870:transcriptional coregulatory
10984:Genes on human chromosome 2
10979:Genes on human chromosome 1
5968:Myogenic regulatory factors
4806:Science China Life Sciences
4133:Current Medicinal Chemistry
3641:Current Medicinal Chemistry
3049:10.1152/ajprenal.00174.2010
1334:and the restoration of the
1326:and tumors. The hypoxia in
11020:
5514:short scientific animation
5480:Hypoxia-Inducible+Factor+1
5440:– via Business Wire.
5334:10.1038/s41591-021-01324-7
5177:Behavioural Brain Research
4867:10.1007/s13105-021-00791-3
4145:10.2174/092986711796391606
3795:10.1016/j.kint.2016.07.019
3680:Nature Reviews. Nephrology
3653:10.2174/092986707781058850
2706:10.1152/physiol.00001.2004
1489:production in adult life.
1463:A kinase–anchoring protein
1316:formation of blood vessels
883:Hypoxia-inducible factor-1
877:
10949:
10701:
10688:
10031:
10017:
9788:(3.5) Tryptophan clusters
8278:
8259:
6776:
6759:
5574:
5561:
5189:10.1016/j.bbr.2009.11.010
5132:Molecular Cancer Research
5060:10.1017/S0007114510002217
4818:10.1007/s11427-017-9178-y
4768:10.1186/s13578-017-0190-2
4720:10.1016/j.lfs.2019.03.056
4657:Frontiers in Pharmacology
4620:10.1016/j.mam.2015.12.004
4532:10.1007/s10522-016-9655-7
4311:Drug Testing and Analysis
4233:10.1007/s00109-012-0882-3
4102:10.1007/s00204-015-1549-y
3977:Cases A (December 2007).
3887:10.1007/s40262-017-0551-3
3875:Clinical Pharmacokinetics
3743:10.1007/s12325-017-0508-9
3382:Aesthetic Surgery Journal
2948:10.1126/scisignal.2000026
2419:10.1007/s00018-008-7472-0
1792:10.1024/0300-9831/a000159
1653:von Hippel–Lindau disease
1301:haematopoietic stem cells
1067:
998:
924:
887:
762:Hypoxia-inducible factors
726:
585:
436:
287:
138:
10609:(4.10) Cold-shock domain
5484:Medical Subject Headings
4670:10.3389/fphar.2016.00184
2087:10.1074/jbc.271.30.17771
1602:phenethyl isothiocyanate
5555:intracellular receptors
5002:10.1073/pnas.2305537120
4972:10.1073/pnas.0909353106
4651:Hua S, Dias TH (2016).
3839:10.1124/jpet.117.242503
3692:10.1038/nrneph.2015.193
3232:10.1073/pnas.1413445112
3174:10.1089/wound.2013.0520
2988:The Biochemical Journal
2901:10.1126/science.aaw8373
2844:10.1126/science.aaw1026
2788:10.1126/science.aau5870
2583:10.1073/pnas.1002339107
2285:10.1126/science.1073440
1959:10.1073/pnas.92.12.5510
1821:C M, D L (2021-09-29).
1630:neuroprotective effects
1572:Inflammation and cancer
1519:As a therapeutic target
1431:(VEGF), which promotes
1402:succinate dehydrogenase
1380:HIF prolyl-hydroxylases
844:(PAS) subfamily of the
499:HIF2B, KIAA0307, bHLHe1
350:HIF2A, MOP2, PASD2, HLF
4082:Archives of Toxicology
3162:Advances in Wound Care
3031:Haase VH (July 2010).
2735:Russo E (April 2003).
2342:10.1073/pnas.082117899
2228:10.1074/jbc.M501755200
1899:10.1074/jbc.270.3.1230
1743:10.1002/cmdc.201600012
1367:
846:basic helix-loop-helix
786:adenosine triphosphate
10999:Transcription factors
10318:TATA-binding proteins
5551:Transcription factors
5285:10.3892/etm.2017.4049
5218:Xing J, Lu J (2016).
5019:|...}}
4996:(Retracted, see
4755:Cell & Bioscience
4058:10.1093/jnci/95.7.516
2666:Perkel J (May 2001).
2376:Journal of Stem Cells
1840:10.3390/cells10102595
1579:transcription factors
1423:enzymes, which allow
1364:
770:transcription factors
5093:Drug Discovery Today
4283:10.1210/jc.2016-1279
3782:Kidney International
3543:www.handelsblatt.com
1657:renal cell carcinoma
1591:rheumatoid arthritis
1454:winner for Medicine
1299:HIF1α expression in
10813:(0.6) Miscellaneous
10344:High-mobility group
10040:Rel homology region
7030:Testicular receptor
6771:DNA-binding domains
4963:2009PNAS..10617910L
4094:2016ArTox..90.1141D
4017:(24): 11039–11049.
3936:2014PLoSO...9k1838F
3730:Advances in Therapy
3394:10.1093/asj/sjaa142
3223:2015PNAS..112...94D
2893:2019Sci...363.1148G
2887:(6432): 1148–1149.
2836:2019Sci...363.1217C
2830:(6432): 1217–1222.
2779:2019Sci...363.1222B
2773:(6432): 1222–1226.
2629:1999Natur.399..271M
2574:2010PNAS..10712722F
2333:2002PNAS...99.5367F
2276:2002Sci...296.1886M
2170:1997CBio....7R.674P
1950:1995PNAS...92.5510W
1774:Rl S, Ja Z (2013).
1511:and pharmacologist
1391:E3 ubiquitin ligase
812:were presented the
10178:p53 p63 p73 family
9751:Heat shock factors
4914:10.1111/febs.13578
3434:10.1111/jocd.13356
3000:10.1042/BJ20080476
1638:spinal cord injury
1456:William Kaelin Jr.
1368:
806:Peter J. Ratcliffe
802:William Kaelin Jr.
10961:
10960:
10945:
10944:
10941:
10940:
10684:
10683:
10680:
10679:
10013:
10012:
10009:
10008:
9255:
9254:
8895:
8894:
8255:
8254:
8251:
8250:
7243:
7242:
7099:Mineralocorticoid
6755:
6754:
6751:
6750:
6455:
6454:
5568:(1) Basic domains
5237:10.1159/000445643
4812:(10): 1114–1124.
4573:(10): 3716–3724.
4276:(12): 4834–4842.
4184:10.1021/ml3004632
3483:10.1159/000506155
3427:(11): 2936–2945.
3325:10.1111/wrr.12667
2936:Science Signaling
2010:978-1-4613-4699-9
1292:
1291:
1167:
1166:
1163:
1162:
1159:
1158:
1121:structure summary
987:
986:
983:
982:
978:structure summary
858:central region –
759:
758:
755:
754:
618:
617:
614:
613:
469:
468:
465:
464:
320:
319:
316:
315:
171:
170:
167:
166:
16:(Redirected from
11011:
10785:-related factors
10703:
10690:
10591:(4.9) Grainyhead
10033:
10019:
9971:(3.6) TEA domain
9261:(3.2) Paired box
8902:
8636:
8630:
8324:
8318:
8311:
8307:
8301:
8292:
8280:
8269:Helix-turn-helix
8261:
7223:
7203:
7178:
7141:
7111:Estrogen related
7060:
6956:
6804:
6797:
6785:Nuclear receptor
6778:
6761:
6440:
6361:
6294:
6163:
6108:
5917:
5912:
5576:
5563:
5544:
5537:
5530:
5521:
5467:
5466:
5464:
5463:
5448:
5442:
5441:
5439:
5437:
5426:
5420:
5419:
5417:
5415:
5400:
5394:
5393:
5391:
5389:
5384:on 26 April 2021
5370:
5364:
5363:
5345:
5313:
5307:
5306:
5296:
5264:
5258:
5257:
5239:
5215:
5209:
5208:
5172:
5166:
5165:
5147:
5123:
5117:
5116:
5099:(19–20): 853–9.
5088:
5082:
5081:
5071:
5039:
5033:
5032:
5030:
5028:
5020:
4994:
4984:
4974:
4942:
4936:
4935:
4925:
4902:The FEBS Journal
4893:
4887:
4886:
4846:
4840:
4839:
4829:
4797:
4791:
4790:
4780:
4770:
4746:
4740:
4739:
4699:
4693:
4692:
4682:
4672:
4648:
4642:
4641:
4631:
4614:. 47–48: 24–34.
4607:
4601:
4600:
4590:
4579:10.1172/JCI84433
4558:
4552:
4551:
4515:
4509:
4508:
4498:
4466:
4460:
4459:
4457:
4456:
4450:
4444:. Archived from
4443:
4435:
4429:
4428:
4418:
4386:
4380:
4379:
4343:
4337:
4336:
4326:
4302:
4296:
4295:
4285:
4261:
4255:
4254:
4244:
4212:
4206:
4205:
4195:
4163:
4157:
4156:
4128:
4122:
4121:
4076:
4070:
4069:
4041:
4035:
4034:
4005:
3999:
3998:
3974:
3968:
3967:
3957:
3947:
3915:
3909:
3908:
3898:
3866:
3860:
3859:
3841:
3817:
3808:
3807:
3797:
3788:(5): 1115–1122.
3773:
3764:
3763:
3745:
3721:
3712:
3711:
3671:
3665:
3664:
3636:
3630:
3629:
3627:
3626:
3611:
3605:
3604:
3602:
3601:
3585:
3579:
3578:
3576:
3575:
3560:
3554:
3553:
3551:
3550:
3535:
3529:
3528:
3526:
3525:
3510:
3504:
3503:
3485:
3461:
3455:
3454:
3436:
3412:
3406:
3405:
3377:
3371:
3370:
3368:
3367:
3353:
3347:
3346:
3336:
3304:
3298:
3297:
3261:
3255:
3254:
3244:
3234:
3202:
3196:
3195:
3185:
3153:
3147:
3146:
3136:
3119:(290): 290ra92.
3104:
3098:
3097:
3095:
3093:
3077:
3071:
3070:
3060:
3028:
3022:
3021:
3011:
2979:
2970:
2969:
2959:
2927:
2921:
2920:
2872:
2866:
2865:
2855:
2815:
2809:
2808:
2790:
2758:
2752:
2751:
2749:
2747:
2732:
2726:
2725:
2689:
2683:
2682:
2680:
2678:
2663:
2657:
2656:
2612:
2606:
2605:
2595:
2585:
2553:
2547:
2546:
2536:
2504:
2498:
2497:
2487:
2470:(3): 695e–706e.
2455:
2449:
2448:
2430:
2413:(7–8): 1133–49.
2398:
2392:
2391:
2371:
2365:
2364:
2354:
2344:
2312:
2306:
2305:
2287:
2270:(5574): 1886–9.
2255:
2249:
2248:
2230:
2221:(43): 36047–54.
2206:
2200:
2199:
2181:
2149:
2143:
2142:
2114:
2108:
2107:
2089:
2065:
2059:
2058:
2047:
2041:
2040:
2029:
2023:
2022:
1988:
1982:
1981:
1971:
1961:
1929:
1920:
1919:
1901:
1877:
1871:
1870:
1860:
1842:
1818:
1812:
1811:
1771:
1765:
1764:
1754:
1722:
1716:
1715:
1705:
1673:
1177:
1154:
1148:
1142:
1136:
1069:
1003:
991:
926:
892:
880:
876:
875:
830:highly conserved
810:Gregg L. Semenza
798:Gregg L. Semenza
728:
620:
587:
471:
438:
322:
289:
173:
140:
32:
21:
11019:
11018:
11014:
11013:
11012:
11010:
11009:
11008:
10964:
10963:
10962:
10957:
10937:
10807:
10767:
10736:
10697:
10676:
10626:
10603:
10585:
10335:
10309:
10261:
10164:
10111:
10027:
10005:
9965:
9782:
9742:
9438:
9251:
8900:
8891:
8632:
8631:
8626:
8621:
8320:
8319:
8314:
8303:
8302:
8295:
8274:
8247:
8229:
8142:
8130:
8121:
7336:
7332:
7323:
7252:
7249:(2.2) Other Cys
7239:
7219:
7214:
7199:
7194:
7174:
7169:
7137:
7132:
7067:Steroid hormone
7056:
7051:
6952:
6947:
6811:Thyroid hormone
6800:
6791:
6772:
6747:
6702:
6647:
6545:
6451:
6438:
6436:
6431:
6359:
6354:
6292:
6287:
6158:
6156:
6151:
6106:
6101:
5915:
5896:
5570:
5557:
5548:
5476:
5471:
5470:
5461:
5459:
5458:. 16 March 2021
5450:
5449:
5445:
5435:
5433:
5428:
5427:
5423:
5413:
5411:
5410:(Press release)
5402:
5401:
5397:
5387:
5385:
5372:
5371:
5367:
5315:
5314:
5310:
5266:
5265:
5261:
5217:
5216:
5212:
5174:
5173:
5169:
5125:
5124:
5120:
5090:
5089:
5085:
5041:
5040:
5036:
5022:
5014:
5012:
4995:
4957:(42): 17910–5.
4944:
4943:
4939:
4895:
4894:
4890:
4848:
4847:
4843:
4799:
4798:
4794:
4748:
4747:
4743:
4701:
4700:
4696:
4650:
4649:
4645:
4609:
4608:
4604:
4560:
4559:
4555:
4517:
4516:
4512:
4487:10.1038/nrd4422
4468:
4467:
4463:
4454:
4452:
4448:
4441:
4437:
4436:
4432:
4388:
4387:
4383:
4345:
4344:
4340:
4324:10.1002/dta.390
4304:
4303:
4299:
4263:
4262:
4258:
4214:
4213:
4209:
4165:
4164:
4160:
4139:(21): 3168–89.
4130:
4129:
4125:
4078:
4077:
4073:
4043:
4042:
4038:
4007:
4006:
4002:
3976:
3975:
3971:
3930:(11): e111838.
3917:
3916:
3912:
3868:
3867:
3863:
3819:
3818:
3811:
3775:
3774:
3767:
3723:
3722:
3715:
3673:
3672:
3668:
3647:(17): 1853–62.
3638:
3637:
3633:
3624:
3622:
3613:
3612:
3608:
3599:
3597:
3587:
3586:
3582:
3573:
3571:
3562:
3561:
3557:
3548:
3546:
3537:
3536:
3532:
3523:
3521:
3512:
3511:
3507:
3463:
3462:
3458:
3414:
3413:
3409:
3379:
3378:
3374:
3365:
3363:
3355:
3354:
3350:
3306:
3305:
3301:
3263:
3262:
3258:
3204:
3203:
3199:
3155:
3154:
3150:
3106:
3105:
3101:
3091:
3089:
3079:
3078:
3074:
3030:
3029:
3025:
2981:
2980:
2973:
2929:
2928:
2924:
2874:
2873:
2869:
2817:
2816:
2812:
2760:
2759:
2755:
2745:
2743:
2734:
2733:
2729:
2691:
2690:
2686:
2676:
2674:
2665:
2664:
2660:
2623:(6733): 271–5.
2614:
2613:
2609:
2568:(28): 12722–7.
2555:
2554:
2550:
2506:
2505:
2501:
2457:
2456:
2452:
2400:
2399:
2395:
2373:
2372:
2368:
2314:
2313:
2309:
2257:
2256:
2252:
2208:
2207:
2203:
2158:Current Biology
2151:
2150:
2146:
2116:
2115:
2111:
2080:(30): 17771–8.
2067:
2066:
2062:
2049:
2048:
2044:
2031:
2030:
2026:
2011:
1990:
1989:
1985:
1931:
1930:
1923:
1879:
1878:
1874:
1820:
1819:
1815:
1773:
1772:
1768:
1724:
1723:
1719:
1675:
1674:
1670:
1665:
1646:
1614:
1574:
1526:
1521:
1509:Dominik Duscher
1495:
1446:and reprograms
1359:
1320:vascular system
1312:differentiating
1297:
1172:
1150:
1144:
1138:
1132:
1006:
895:
826:
794:
28:
23:
22:
15:
12:
11:
5:
11017:
11015:
11007:
11006:
11001:
10996:
10991:
10986:
10981:
10976:
10966:
10965:
10959:
10958:
10950:
10947:
10946:
10943:
10942:
10939:
10938:
10936:
10935:
10926:
10925:
10924:
10919:
10914:
10904:
10899:
10898:
10897:
10892:
10887:
10877:
10876:
10875:
10870:
10860:
10855:
10854:
10853:
10848:
10843:
10838:
10833:
10828:
10817:
10815:
10809:
10808:
10806:
10805:
10800:
10795:
10789:
10787:
10769:
10768:
10766:
10765:
10760:
10755:
10749:
10747:
10738:
10737:
10735:
10734:
10729:
10728:
10727:
10722:
10711:
10709:
10699:
10698:
10693:
10686:
10685:
10682:
10681:
10678:
10677:
10675:
10674:
10673:
10672:
10667:
10662:
10657:
10652:
10647:
10636:
10634:
10628:
10627:
10625:
10624:
10619:
10613:
10611:
10605:
10604:
10602:
10601:
10595:
10593:
10587:
10586:
10584:
10583:
10582:
10581:
10576:
10571:
10566:
10556:
10555:
10554:
10549:
10548:
10547:
10542:
10537:
10522:
10517:
10512:
10511:
10510:
10505:
10500:
10495:
10490:
10485:
10480:
10475:
10470:
10465:
10460:
10455:
10450:
10445:
10440:
10435:
10425:
10424:
10423:
10418:
10408:
10407:
10406:
10401:
10396:
10391:
10381:
10380:
10379:
10374:
10369:
10364:
10354:
10348:
10346:
10337:
10336:
10334:
10333:
10328:
10322:
10320:
10311:
10310:
10308:
10307:
10302:
10301:
10300:
10295:
10290:
10285:
10274:
10272:
10263:
10262:
10260:
10259:
10254:
10253:
10252:
10247:
10242:
10237:
10232:
10227:
10222:
10217:
10212:
10207:
10197:
10196:
10195:
10190:
10185:
10174:
10172:
10170:(4.3) p53-like
10166:
10165:
10163:
10162:
10161:
10160:
10155:
10150:
10145:
10140:
10135:
10124:
10122:
10113:
10112:
10110:
10109:
10108:
10107:
10102:
10097:
10092:
10087:
10077:
10076:
10075:
10070:
10065:
10060:
10055:
10044:
10042:
10029:
10028:
10022:
10015:
10014:
10011:
10010:
10007:
10006:
10004:
10003:
10002:
10001:
9996:
9991:
9986:
9975:
9973:
9967:
9966:
9964:
9963:
9958:
9953:
9952:
9951:
9946:
9941:
9936:
9931:
9926:
9921:
9916:
9906:
9901:
9900:
9899:
9894:
9889:
9884:
9874:
9873:
9872:
9867:
9862:
9857:
9847:
9842:
9841:
9840:
9835:
9830:
9820:
9815:
9814:
9813:
9808:
9803:
9792:
9790:
9784:
9783:
9781:
9780:
9779:
9778:
9773:
9768:
9755:
9753:
9744:
9743:
9741:
9740:
9739:
9738:
9733:
9728:
9723:
9718:
9713:
9708:
9703:
9698:
9693:
9688:
9683:
9678:
9673:
9668:
9663:
9658:
9653:
9648:
9643:
9638:
9633:
9628:
9623:
9618:
9613:
9608:
9603:
9598:
9593:
9588:
9583:
9578:
9573:
9568:
9563:
9558:
9553:
9548:
9543:
9538:
9533:
9528:
9523:
9518:
9513:
9508:
9503:
9498:
9488:
9487:
9486:
9481:
9476:
9471:
9466:
9455:
9453:
9440:
9439:
9437:
9436:
9435:
9434:
9433:
9432:
9427:
9422:
9412:
9411:
9410:
9405:
9395:
9390:
9380:
9375:
9370:
9365:
9360:
9355:
9354:
9353:
9348:
9338:
9333:
9332:
9331:
9326:
9318:
9317:
9316:
9311:
9306:
9301:
9296:
9291:
9286:
9281:
9276:
9265:
9263:
9257:
9256:
9253:
9252:
9250:
9249:
9248:
9247:
9242:
9232:
9227:
9226:
9225:
9220:
9215:
9210:
9205:
9200:
9191:
9186:
9181:
9172:
9162:
9161:
9160:
9155:
9150:
9145:
9140:
9135:
9130:
9125:
9120:
9110:
9109:
9108:
9107:
9106:
9101:
9096:
9091:
9086:
9076:
9075:
9074:
9069:
9059:
9058:
9057:
9052:
9047:
9037:
9036:
9035:
9030:
9020:
9019:
9018:
9013:
9008:
9003:
8998:
8993:
8988:
8975:
8970:
8969:
8968:
8963:
8953:
8948:
8943:
8942:
8941:
8936:
8931:
8921:
8916:
8911:
8905:
8903:
8897:
8896:
8893:
8892:
8890:
8889:
8884:
8879:
8874:
8869:
8864:
8859:
8858:
8857:
8852:
8847:
8842:
8837:
8832:
8827:
8822:
8817:
8812:
8807:
8797:
8792:
8791:
8790:
8785:
8775:
8770:
8765:
8760:
8755:
8754:
8753:
8748:
8738:
8737:
8736:
8731:
8719:
8718:
8717:
8712:
8707:
8702:
8697:
8692:
8682:
8681:
8680:
8675:
8665:
8660:
8655:
8650:
8645:
8639:
8637:
8623:
8622:
8620:
8619:
8614:
8609:
8604:
8603:
8602:
8597:
8592:
8587:
8582:
8577:
8572:
8567:
8562:
8557:
8552:
8547:
8542:
8537:
8532:
8527:
8522:
8517:
8512:
8507:
8502:
8497:
8492:
8487:
8482:
8477:
8472:
8467:
8462:
8457:
8452:
8447:
8442:
8437:
8432:
8427:
8422:
8417:
8407:
8402:
8397:
8392:
8388:extended Hox:
8386:
8385:
8384:
8383:
8382:
8377:
8372:
8362:
8361:
8360:
8350:
8349:
8348:
8343:
8327:
8325:
8308:
8289:
8276:
8275:
8264:
8257:
8256:
8253:
8252:
8249:
8248:
8246:
8245:
8239:
8237:
8231:
8230:
8228:
8227:
8222:
8221:
8220:
8215:
8210:
8205:
8200:
8190:
8189:
8188:
8183:
8178:
8168:
8163:
8158:
8152:
8150:
8144:
8143:
8141:
8140:
8134:
8132:
8128:
8123:
8122:
8120:
8119:
8118:
8117:
8112:
8107:
8102:
8097:
8092:
8087:
8082:
8077:
8072:
8067:
8062:
8057:
8052:
8047:
8042:
8037:
8032:
8027:
8022:
8017:
8012:
8007:
8002:
7997:
7992:
7987:
7982:
7977:
7972:
7967:
7962:
7957:
7952:
7947:
7942:
7937:
7932:
7927:
7922:
7917:
7912:
7907:
7902:
7897:
7892:
7882:
7881:
7880:
7875:
7870:
7865:
7860:
7855:
7850:
7845:
7835:
7834:
7833:
7828:
7818:
7813:
7808:
7807:
7806:
7801:
7796:
7791:
7781:
7776:
7771:
7766:
7761:
7760:
7759:
7758:
7757:
7752:
7747:
7742:
7737:
7727:
7726:
7725:
7720:
7715:
7710:
7705:
7700:
7695:
7690:
7685:
7680:
7675:
7670:
7665:
7660:
7655:
7650:
7635:
7634:
7633:
7628:
7618:
7617:
7616:
7611:
7606:
7596:
7595:
7594:
7589:
7584:
7574:
7573:
7572:
7567:
7557:
7556:
7555:
7550:
7545:
7540:
7535:
7530:
7525:
7515:
7510:
7505:
7504:
7503:
7498:
7493:
7488:
7478:
7473:
7468:
7467:
7466:
7461:
7456:
7444:
7438:
7437:
7436:
7435:
7434:
7433:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7388:
7383:
7378:
7377:
7376:
7371:
7361:
7356:
7351:
7340:
7338:
7334:
7330:
7325:
7324:
7322:
7321:
7316:
7315:
7314:
7309:
7304:
7294:
7293:
7292:
7287:
7282:
7277:
7272:
7267:
7256:
7254:
7250:
7245:
7244:
7241:
7240:
7238:
7237:
7232:
7226:
7224:
7216:
7215:
7213:
7212:
7206:
7204:
7196:
7195:
7193:
7192:
7187:
7181:
7179:
7171:
7170:
7168:
7167:
7166:
7165:
7160:
7155:
7144:
7142:
7134:
7133:
7131:
7130:
7129:
7128:
7123:
7118:
7108:
7107:
7106:
7101:
7096:
7094:Glucocorticoid
7091:
7090:
7089:
7084:
7074:
7063:
7061:
7053:
7052:
7050:
7049:
7044:
7043:
7042:
7037:
7027:
7026:
7025:
7020:
7015:
7005:
7000:
6999:
6998:
6993:
6983:
6978:
6977:
6976:
6971:
6959:
6957:
6949:
6948:
6946:
6945:
6940:
6939:
6938:
6933:
6923:
6922:
6921:
6916:
6911:
6901:
6900:
6899:
6894:
6889:
6879:
6874:
6873:
6872:
6867:
6862:
6852:
6851:
6850:
6845:
6835:
6830:
6825:
6824:
6823:
6818:
6807:
6805:
6794:
6789:
6774:
6773:
6764:
6757:
6756:
6753:
6752:
6749:
6748:
6746:
6745:
6744:
6743:
6738:
6733:
6728:
6723:
6712:
6710:
6704:
6703:
6701:
6700:
6699:
6698:
6693:
6688:
6683:
6678:
6673:
6668:
6657:
6655:
6649:
6648:
6646:
6645:
6644:
6643:
6637:
6636:
6635:
6630:
6620:
6619:
6618:
6613:
6608:
6603:
6598:
6583:
6582:
6581:
6576:
6571:
6566:
6555:
6553:
6547:
6546:
6544:
6543:
6538:
6537:
6536:
6531:
6521:
6516:
6511:
6506:
6501:
6496:
6491:
6490:
6489:
6484:
6474:
6468:
6466:
6457:
6456:
6453:
6452:
6450:
6449:
6443:
6441:
6433:
6432:
6430:
6429:
6428:
6427:
6422:
6417:
6407:
6406:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6364:
6362:
6356:
6355:
6353:
6352:
6351:
6350:
6345:
6340:
6335:
6325:
6320:
6319:
6318:
6313:
6308:
6297:
6295:
6289:
6288:
6286:
6285:
6284:
6283:
6278:
6268:
6267:
6266:
6261:
6256:
6251:
6241:
6240:
6239:
6234:
6229:
6221:
6220:
6219:
6214:
6209:
6199:
6194:
6193:
6192:
6187:
6177:
6172:
6166:
6164:
6153:
6152:
6150:
6149:
6144:
6139:
6138:
6137:
6132:
6127:
6117:
6111:
6109:
6103:
6102:
6100:
6099:
6094:
6093:
6092:
6091:
6090:
6085:
6075:
6065:
6064:
6063:
6058:
6048:
6047:
6046:
6041:
6031:
6030:
6029:
6024:
6019:
6009:
6008:
6007:
6002:
5992:
5991:
5990:
5985:
5980:
5975:
5965:
5960:
5959:
5958:
5953:
5943:
5938:
5937:
5936:
5931:
5920:
5918:
5909:
5898:
5897:
5895:
5894:
5889:
5888:
5887:
5882:
5877:
5867:
5862:
5857:
5856:
5855:
5850:
5845:
5840:
5830:
5829:
5828:
5823:
5818:
5813:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5772:
5771:
5766:
5761:
5751:
5750:
5749:
5744:
5739:
5734:
5729:
5724:
5714:
5709:
5704:
5703:
5702:
5697:
5687:
5686:
5685:
5680:
5675:
5670:
5665:
5660:
5655:
5650:
5640:
5639:
5638:
5633:
5628:
5623:
5618:
5613:
5608:
5603:
5592:
5590:
5583:leucine zipper
5572:
5571:
5566:
5559:
5558:
5549:
5547:
5546:
5539:
5532:
5524:
5518:
5517:
5511:
5505:
5499:
5493:
5487:
5475:
5474:External links
5472:
5469:
5468:
5456:Cancer Network
5443:
5421:
5395:
5365:
5328:(5): 802–805.
5308:
5279:(3): 861–866.
5259:
5210:
5167:
5118:
5083:
5054:(9): 1288–96.
5034:
4937:
4888:
4861:(2): 249–260.
4841:
4792:
4741:
4694:
4643:
4602:
4553:
4520:Biogerontology
4510:
4481:(11): 852–69.
4461:
4430:
4381:
4338:
4317:(11): 830–45.
4297:
4256:
4227:(9): 1079–89.
4207:
4178:(2): 297–301.
4158:
4123:
4088:(5): 1141–50.
4071:
4036:
4000:
3989:(10): 647–54.
3969:
3910:
3861:
3832:(3): 336–347.
3809:
3765:
3736:(4): 848–853.
3713:
3666:
3631:
3619:nachrichten.at
3606:
3580:
3568:Handelszeitung
3555:
3530:
3515:"Tomorrowlabs"
3513:Tomorrowlabs.
3505:
3476:(4): 271–280.
3456:
3407:
3388:(4): 514–524.
3372:
3348:
3319:(3): 300–305.
3299:
3256:
3197:
3168:(5): 390–399.
3148:
3099:
3086:eurekalert.org
3072:
3023:
2971:
2922:
2867:
2810:
2753:
2727:
2684:
2658:
2607:
2548:
2519:(5): 1004–13.
2499:
2450:
2393:
2366:
2327:(8): 5367–72.
2307:
2250:
2201:
2164:(11): R674-7.
2144:
2109:
2060:
2042:
2024:
2009:
1983:
1944:(12): 5510–4.
1921:
1872:
1813:
1786:(3): 188–197.
1766:
1717:
1667:
1666:
1664:
1661:
1645:
1642:
1626:erythropoietin
1613:
1610:
1573:
1570:
1562:erythropoietin
1548:(ZYAN-1), and
1544:(GSK1278863),
1525:
1522:
1520:
1517:
1494:
1491:
1487:erythropoietin
1384:ubiquitination
1358:
1355:
1296:
1293:
1290:
1289:
1286:
1279:
1273:
1272:
1269:
1262:
1256:
1255:
1252:
1245:
1239:
1238:
1235:
1228:
1222:
1221:
1218:
1211:
1205:
1204:
1201:
1194:
1188:
1187:
1184:
1181:
1171:
1168:
1165:
1164:
1161:
1160:
1157:
1156:
1130:
1124:
1123:
1118:
1112:
1111:
1098:
1092:
1091:
1081:
1074:
1073:
1065:
1064:
1051:
1045:
1044:
1039:
1033:
1032:
1027:
1021:
1020:
1017:
1013:
1012:
1008:
1007:
1004:
996:
995:
988:
985:
984:
981:
980:
975:
969:
968:
955:
949:
948:
938:
931:
930:
922:
921:
916:
910:
909:
906:
902:
901:
897:
896:
893:
885:
884:
874:
873:
863:
856:
825:
822:
793:
790:
757:
756:
753:
752:
747:
743:
742:
737:
733:
732:
724:
723:
713:
707:
706:
702:
701:
696:
690:
689:
684:
678:
677:
672:
666:
665:
660:
654:
653:
648:
642:
641:
636:
632:
631:
627:
626:
616:
615:
612:
611:
606:
602:
601:
596:
592:
591:
583:
582:
572:
566:
565:
561:
560:
555:
549:
548:
543:
537:
536:
531:
525:
524:
519:
513:
512:
507:
501:
500:
497:
493:
492:
487:
483:
482:
478:
477:
467:
466:
463:
462:
457:
453:
452:
447:
443:
442:
434:
433:
423:
417:
416:
412:
411:
406:
400:
399:
394:
388:
387:
382:
376:
375:
370:
364:
363:
358:
352:
351:
348:
344:
343:
338:
334:
333:
329:
328:
318:
317:
314:
313:
308:
304:
303:
298:
294:
293:
285:
284:
274:
268:
267:
263:
262:
257:
251:
250:
245:
239:
238:
233:
227:
226:
221:
215:
214:
209:
203:
202:
199:
195:
194:
189:
185:
184:
180:
179:
169:
168:
165:
164:
159:
155:
154:
149:
145:
144:
136:
135:
125:
119:
118:
114:
113:
108:
102:
101:
96:
90:
89:
84:
78:
77:
72:
66:
65:
60:
54:
53:
48:
44:
43:
39:
38:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
11016:
11005:
11002:
11000:
10997:
10995:
10992:
10990:
10987:
10985:
10982:
10980:
10977:
10975:
10972:
10971:
10969:
10956:
10955:
10948:
10934:
10930:
10927:
10923:
10920:
10918:
10915:
10913:
10910:
10909:
10908:
10905:
10903:
10900:
10896:
10893:
10891:
10888:
10886:
10883:
10882:
10881:
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10745:Pocket domain
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10707:(0.2) HMGI(Y)
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6597:
6594:
6593:
6592:
6589:
6588:
6587:
6584:
6580:
6577:
6575:
6572:
6570:
6567:
6565:
6562:
6561:
6560:
6557:
6556:
6554:
6552:
6548:
6542:
6539:
6535:
6532:
6530:
6527:
6526:
6525:
6522:
6520:
6517:
6515:
6512:
6510:
6507:
6505:
6502:
6500:
6497:
6495:
6492:
6488:
6485:
6483:
6480:
6479:
6478:
6475:
6473:
6470:
6469:
6467:
6465:
6462:
6458:
6448:
6445:
6444:
6442:
6434:
6426:
6423:
6421:
6418:
6416:
6413:
6412:
6411:
6408:
6404:
6401:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6370:
6369:
6366:
6365:
6363:
6357:
6349:
6346:
6344:
6341:
6339:
6336:
6334:
6331:
6330:
6329:
6326:
6324:
6321:
6317:
6314:
6312:
6309:
6307:
6304:
6303:
6302:
6299:
6298:
6296:
6290:
6282:
6279:
6277:
6274:
6273:
6272:
6269:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6246:
6245:
6242:
6238:
6235:
6233:
6230:
6228:
6225:
6224:
6222:
6218:
6215:
6213:
6210:
6208:
6205:
6204:
6203:
6200:
6198:
6195:
6191:
6188:
6186:
6183:
6182:
6181:
6178:
6176:
6173:
6171:
6168:
6167:
6165:
6162:
6154:
6148:
6145:
6143:
6140:
6136:
6133:
6131:
6128:
6126:
6123:
6122:
6121:
6118:
6116:
6113:
6112:
6110:
6104:
6098:
6095:
6089:
6086:
6084:
6081:
6080:
6079:
6076:
6074:
6071:
6070:
6069:
6066:
6062:
6059:
6057:
6054:
6053:
6052:
6049:
6045:
6042:
6040:
6037:
6036:
6035:
6032:
6028:
6025:
6023:
6020:
6018:
6015:
6014:
6013:
6010:
6006:
6003:
6001:
5998:
5997:
5996:
5993:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5970:
5969:
5966:
5964:
5961:
5957:
5954:
5952:
5949:
5948:
5947:
5944:
5942:
5939:
5935:
5932:
5930:
5927:
5926:
5925:
5922:
5921:
5919:
5913:
5910:
5907:
5903:
5899:
5893:
5890:
5886:
5883:
5881:
5878:
5876:
5873:
5872:
5871:
5868:
5866:
5863:
5861:
5858:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5835:
5834:
5831:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5809:
5808:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5770:
5767:
5765:
5762:
5760:
5757:
5756:
5755:
5752:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5719:
5718:
5715:
5713:
5710:
5708:
5705:
5701:
5698:
5696:
5693:
5692:
5691:
5688:
5684:
5681:
5679:
5676:
5674:
5671:
5669:
5666:
5664:
5661:
5659:
5656:
5654:
5651:
5649:
5646:
5645:
5644:
5641:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5612:
5609:
5607:
5604:
5602:
5599:
5598:
5597:
5594:
5593:
5591:
5588:
5584:
5581:
5577:
5573:
5569:
5564:
5560:
5556:
5552:
5545:
5540:
5538:
5533:
5531:
5526:
5525:
5522:
5515:
5512:
5509:
5506:
5503:
5500:
5497:
5494:
5491:
5488:
5485:
5481:
5478:
5477:
5473:
5457:
5453:
5447:
5444:
5431:
5425:
5422:
5409:
5405:
5399:
5396:
5383:
5379:
5375:
5369:
5366:
5361:
5357:
5353:
5349:
5344:
5339:
5335:
5331:
5327:
5323:
5319:
5312:
5309:
5304:
5300:
5295:
5290:
5286:
5282:
5278:
5274:
5270:
5263:
5260:
5255:
5251:
5247:
5243:
5238:
5233:
5230:(2): 511–20.
5229:
5225:
5221:
5214:
5211:
5206:
5202:
5198:
5194:
5190:
5186:
5182:
5178:
5171:
5168:
5163:
5159:
5155:
5151:
5146:
5141:
5137:
5133:
5129:
5122:
5119:
5114:
5110:
5106:
5102:
5098:
5094:
5087:
5084:
5079:
5075:
5070:
5065:
5061:
5057:
5053:
5049:
5045:
5038:
5035:
5026:
5018:
5011:
5007:
5003:
4999:
4992:
4988:
4983:
4978:
4973:
4968:
4964:
4960:
4956:
4952:
4948:
4941:
4938:
4933:
4929:
4924:
4919:
4915:
4911:
4908:(3): 413–24.
4907:
4903:
4899:
4892:
4889:
4884:
4880:
4876:
4872:
4868:
4864:
4860:
4856:
4852:
4845:
4842:
4837:
4833:
4828:
4823:
4819:
4815:
4811:
4807:
4803:
4796:
4793:
4788:
4784:
4779:
4774:
4769:
4764:
4760:
4756:
4752:
4745:
4742:
4737:
4733:
4729:
4725:
4721:
4717:
4713:
4709:
4708:Life Sciences
4705:
4698:
4695:
4690:
4686:
4681:
4676:
4671:
4666:
4662:
4658:
4654:
4647:
4644:
4639:
4635:
4630:
4625:
4621:
4617:
4613:
4606:
4603:
4598:
4594:
4589:
4584:
4580:
4576:
4572:
4568:
4564:
4557:
4554:
4549:
4545:
4541:
4537:
4533:
4529:
4526:(4): 655–80.
4525:
4521:
4514:
4511:
4506:
4502:
4497:
4492:
4488:
4484:
4480:
4476:
4472:
4465:
4462:
4451:on 2015-09-23
4447:
4440:
4434:
4431:
4426:
4422:
4417:
4412:
4408:
4404:
4401:(6): 2140–7.
4400:
4396:
4392:
4385:
4382:
4377:
4373:
4369:
4365:
4361:
4357:
4353:
4349:
4342:
4339:
4334:
4330:
4325:
4320:
4316:
4312:
4308:
4301:
4298:
4293:
4289:
4284:
4279:
4275:
4271:
4267:
4260:
4257:
4252:
4248:
4243:
4238:
4234:
4230:
4226:
4222:
4218:
4211:
4208:
4203:
4199:
4194:
4189:
4185:
4181:
4177:
4173:
4169:
4162:
4159:
4154:
4150:
4146:
4142:
4138:
4134:
4127:
4124:
4119:
4115:
4111:
4107:
4103:
4099:
4095:
4091:
4087:
4083:
4075:
4072:
4067:
4063:
4059:
4055:
4052:(7): 516–25.
4051:
4047:
4040:
4037:
4032:
4028:
4024:
4020:
4016:
4012:
4004:
4001:
3996:
3992:
3988:
3984:
3980:
3973:
3970:
3965:
3961:
3956:
3951:
3946:
3941:
3937:
3933:
3929:
3925:
3921:
3914:
3911:
3906:
3902:
3897:
3892:
3888:
3884:
3881:(1): 87–102.
3880:
3876:
3872:
3865:
3862:
3857:
3853:
3849:
3845:
3840:
3835:
3831:
3827:
3823:
3816:
3814:
3810:
3805:
3801:
3796:
3791:
3787:
3783:
3779:
3772:
3770:
3766:
3761:
3757:
3753:
3749:
3744:
3739:
3735:
3731:
3727:
3720:
3718:
3714:
3709:
3705:
3701:
3697:
3693:
3689:
3686:(3): 157–68.
3685:
3681:
3677:
3670:
3667:
3662:
3658:
3654:
3650:
3646:
3642:
3635:
3632:
3620:
3616:
3610:
3607:
3595:
3591:
3584:
3581:
3569:
3565:
3559:
3556:
3544:
3540:
3534:
3531:
3520:
3516:
3509:
3506:
3501:
3497:
3493:
3489:
3484:
3479:
3475:
3471:
3467:
3460:
3457:
3452:
3448:
3444:
3440:
3435:
3430:
3426:
3422:
3418:
3411:
3408:
3403:
3399:
3395:
3391:
3387:
3383:
3376:
3373:
3362:
3358:
3352:
3349:
3344:
3340:
3335:
3330:
3326:
3322:
3318:
3314:
3310:
3303:
3300:
3295:
3291:
3287:
3283:
3279:
3275:
3271:
3267:
3260:
3257:
3252:
3248:
3243:
3238:
3233:
3228:
3224:
3220:
3216:
3212:
3208:
3201:
3198:
3193:
3189:
3184:
3179:
3175:
3171:
3167:
3163:
3159:
3152:
3149:
3144:
3140:
3135:
3130:
3126:
3122:
3118:
3114:
3110:
3103:
3100:
3087:
3083:
3076:
3073:
3068:
3064:
3059:
3054:
3050:
3046:
3042:
3038:
3034:
3027:
3024:
3019:
3015:
3010:
3005:
3001:
2997:
2994:(3): 477–84.
2993:
2989:
2985:
2978:
2976:
2972:
2967:
2963:
2958:
2953:
2949:
2945:
2941:
2937:
2933:
2926:
2923:
2918:
2914:
2910:
2906:
2902:
2898:
2894:
2890:
2886:
2882:
2878:
2871:
2868:
2863:
2859:
2854:
2849:
2845:
2841:
2837:
2833:
2829:
2825:
2821:
2814:
2811:
2806:
2802:
2798:
2794:
2789:
2784:
2780:
2776:
2772:
2768:
2764:
2757:
2754:
2742:
2741:The Scientist
2738:
2731:
2728:
2723:
2719:
2715:
2711:
2707:
2703:
2700:(4): 176–82.
2699:
2695:
2688:
2685:
2673:
2672:The Scientist
2669:
2662:
2659:
2654:
2650:
2646:
2642:
2638:
2637:10.1038/20459
2634:
2630:
2626:
2622:
2618:
2611:
2608:
2603:
2599:
2594:
2589:
2584:
2579:
2575:
2571:
2567:
2563:
2559:
2552:
2549:
2544:
2540:
2535:
2530:
2526:
2522:
2518:
2514:
2510:
2503:
2500:
2495:
2491:
2486:
2481:
2477:
2473:
2469:
2465:
2461:
2454:
2451:
2446:
2442:
2438:
2434:
2429:
2424:
2420:
2416:
2412:
2408:
2404:
2397:
2394:
2389:
2385:
2382:(2): 97–106.
2381:
2377:
2370:
2367:
2362:
2358:
2353:
2348:
2343:
2338:
2334:
2330:
2326:
2322:
2318:
2311:
2308:
2303:
2299:
2295:
2291:
2286:
2281:
2277:
2273:
2269:
2265:
2261:
2254:
2251:
2246:
2242:
2238:
2234:
2229:
2224:
2220:
2216:
2212:
2205:
2202:
2197:
2193:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2159:
2155:
2148:
2145:
2140:
2136:
2132:
2128:
2124:
2120:
2113:
2110:
2105:
2101:
2097:
2093:
2088:
2083:
2079:
2075:
2071:
2064:
2061:
2056:
2052:
2046:
2043:
2038:
2034:
2028:
2025:
2020:
2016:
2012:
2006:
2002:
1998:
1994:
1987:
1984:
1979:
1975:
1970:
1965:
1960:
1955:
1951:
1947:
1943:
1939:
1935:
1928:
1926:
1922:
1917:
1913:
1909:
1905:
1900:
1895:
1892:(3): 1230–7.
1891:
1887:
1883:
1876:
1873:
1868:
1864:
1859:
1854:
1850:
1846:
1841:
1836:
1832:
1828:
1824:
1817:
1814:
1809:
1805:
1801:
1797:
1793:
1789:
1785:
1781:
1777:
1770:
1767:
1762:
1758:
1753:
1748:
1744:
1740:
1737:(8): 773–86.
1736:
1732:
1728:
1721:
1718:
1713:
1709:
1704:
1699:
1695:
1691:
1688:(3): 325–34.
1687:
1683:
1679:
1672:
1669:
1662:
1660:
1658:
1654:
1650:
1643:
1641:
1639:
1635:
1631:
1627:
1623:
1619:
1611:
1609:
1607:
1603:
1599:
1594:
1592:
1588:
1584:
1580:
1571:
1569:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1539:
1535:
1531:
1523:
1518:
1516:
1514:
1510:
1505:
1500:
1492:
1490:
1488:
1484:
1480:
1476:
1472:
1466:
1464:
1459:
1457:
1453:
1449:
1445:
1442:
1438:
1434:
1430:
1426:
1422:
1417:
1415:
1414:pseudohypoxia
1411:
1407:
1403:
1398:
1396:
1392:
1389:
1385:
1381:
1377:
1374:at conserved
1373:
1363:
1356:
1354:
1352:
1348:
1347:growth plates
1344:
1339:
1337:
1333:
1332:keratinocytes
1329:
1325:
1321:
1317:
1313:
1308:
1306:
1302:
1294:
1287:
1285:
1284:
1280:
1278:
1275:
1274:
1270:
1268:
1267:
1263:
1261:
1258:
1257:
1253:
1251:
1250:
1246:
1244:
1241:
1240:
1236:
1234:
1233:
1229:
1227:
1224:
1223:
1219:
1217:
1216:
1212:
1210:
1207:
1206:
1202:
1200:
1199:
1195:
1193:
1190:
1189:
1185:
1182:
1179:
1178:
1175:
1169:
1153:
1147:
1141:
1135:
1131:
1129:
1125:
1122:
1119:
1117:
1113:
1110:
1106:
1102:
1099:
1097:
1093:
1089:
1085:
1082:
1079:
1075:
1070:
1066:
1063:
1059:
1055:
1052:
1050:
1046:
1043:
1040:
1038:
1034:
1031:
1028:
1026:
1022:
1018:
1014:
1009:
1002:
997:
992:
989:
979:
976:
974:
970:
967:
963:
959:
956:
954:
950:
946:
942:
939:
936:
932:
927:
923:
920:
917:
915:
911:
907:
903:
898:
891:
886:
881:
878:
871:
867:
864:
861:
857:
854:
851:
850:
849:
847:
843:
839:
835:
831:
823:
821:
819:
815:
811:
807:
803:
799:
791:
789:
787:
783:
782:pseudohypoxia
779:
775:
771:
767:
763:
751:
748:
744:
741:
738:
734:
729:
725:
722:
721:
717:
714:
712:
708:
703:
700:
697:
695:
691:
688:
685:
683:
679:
676:
673:
671:
667:
664:
661:
659:
655:
652:
649:
647:
643:
640:
637:
633:
628:
625:
621:
610:
607:
603:
600:
597:
593:
588:
584:
581:
580:
576:
573:
571:
567:
562:
559:
556:
554:
550:
547:
544:
542:
538:
535:
532:
530:
526:
523:
520:
518:
514:
511:
508:
506:
502:
498:
494:
491:
488:
484:
479:
476:
472:
461:
458:
454:
451:
448:
444:
439:
435:
432:
431:
427:
424:
422:
418:
413:
410:
407:
405:
401:
398:
395:
393:
389:
386:
383:
381:
377:
374:
371:
369:
365:
362:
359:
357:
353:
349:
345:
342:
339:
335:
330:
327:
323:
312:
309:
305:
302:
299:
295:
290:
286:
283:
282:
278:
275:
273:
269:
264:
261:
258:
256:
252:
249:
246:
244:
240:
237:
234:
232:
228:
225:
222:
220:
216:
213:
210:
208:
204:
201:HIF1B, bHLHe2
200:
196:
193:
190:
186:
181:
178:
174:
163:
160:
156:
153:
150:
146:
141:
137:
134:
133:
129:
126:
124:
120:
115:
112:
109:
107:
103:
100:
97:
95:
91:
88:
85:
83:
79:
76:
73:
71:
67:
64:
61:
59:
55:
52:
49:
45:
40:
37:
33:
30:
19:
10951:
10906:
10862:
10820:
10812:
10784:
10778:
10772:
10741:
10706:
10694:
10631:
10608:
10590:
10558:
10529:
10410:
10340:
10314:
10266:
10169:
10116:
10036:
10024:
9978:
9970:
9876:
9822:
9795:
9787:
9758:
9747:
9491:FOX proteins
9451:winged helix
9443:
9414:
9397:
9340:
9260:
9234:
9112:
9078:
9061:
9039:
9022:
8955:
8923:
8777:
8740:
8721:
8667:
8633:
8627:
8321:
8315:
8304:
8298:Antennapedia
8296:
8283:
8271:
8265:
8234:
8192:
8170:
8147:
8126:
7884:
7837:
7783:
7729:
7642:
7620:
7598:
7576:
7559:
7517:
7446:
7328:
7296:
7248:
7220:
7200:
7175:
7138:
7104:Progesterone
7057:
6953:
6801:
6787:
6781:
6765:
6707:
6660:
6652:
6550:
6460:
6409:
6367:
6327:
6300:
6270:
6243:
6201:
6077:
6067:
6050:
6033:
5945:
5901:
5869:
5832:
5689:
5579:
5567:
5460:. Retrieved
5455:
5446:
5434:. Retrieved
5424:
5412:. Retrieved
5407:
5398:
5386:. Retrieved
5382:the original
5377:
5374:"Belzutifan"
5368:
5325:
5321:
5311:
5276:
5272:
5262:
5227:
5223:
5213:
5180:
5176:
5170:
5138:(9): 601–5.
5135:
5131:
5121:
5096:
5092:
5086:
5051:
5047:
5037:
5023:{{
5015:{{
4954:
4950:
4940:
4905:
4901:
4891:
4858:
4854:
4844:
4809:
4805:
4795:
4758:
4754:
4744:
4711:
4707:
4697:
4660:
4656:
4646:
4611:
4605:
4570:
4566:
4556:
4523:
4519:
4513:
4478:
4474:
4464:
4453:. Retrieved
4446:the original
4433:
4398:
4394:
4384:
4354:(4): 405–9.
4351:
4347:
4341:
4314:
4310:
4300:
4273:
4269:
4259:
4224:
4220:
4210:
4175:
4171:
4161:
4136:
4132:
4126:
4085:
4081:
4074:
4049:
4045:
4039:
4014:
4010:
4003:
3986:
3982:
3972:
3927:
3923:
3913:
3878:
3874:
3864:
3829:
3825:
3785:
3781:
3733:
3729:
3683:
3679:
3669:
3644:
3640:
3634:
3623:. Retrieved
3618:
3609:
3598:. Retrieved
3593:
3583:
3572:. Retrieved
3567:
3558:
3547:. Retrieved
3542:
3533:
3522:. Retrieved
3519:Tomorrowlabs
3518:
3508:
3473:
3469:
3459:
3424:
3420:
3410:
3385:
3381:
3375:
3364:. Retrieved
3360:
3351:
3316:
3312:
3302:
3269:
3265:
3259:
3214:
3210:
3200:
3165:
3161:
3151:
3116:
3112:
3102:
3090:. Retrieved
3085:
3075:
3043:(1): F1-13.
3040:
3036:
3026:
2991:
2987:
2942:(51): ra18.
2939:
2935:
2925:
2884:
2880:
2870:
2827:
2823:
2813:
2770:
2766:
2756:
2744:. Retrieved
2740:
2730:
2697:
2693:
2687:
2675:. Retrieved
2671:
2661:
2620:
2616:
2610:
2565:
2561:
2551:
2516:
2512:
2502:
2467:
2463:
2453:
2410:
2406:
2396:
2379:
2375:
2369:
2324:
2320:
2310:
2267:
2263:
2253:
2218:
2214:
2204:
2161:
2157:
2147:
2125:(9): 331–3.
2122:
2118:
2112:
2077:
2073:
2063:
2054:
2045:
2036:
2027:
1992:
1986:
1941:
1937:
1889:
1885:
1875:
1833:(10): 2595.
1830:
1826:
1816:
1783:
1779:
1769:
1734:
1730:
1720:
1685:
1681:
1671:
1655:-associated
1647:
1615:
1598:angiogenesis
1595:
1582:
1575:
1540:(AKB-6548),
1527:
1513:Dominik Thor
1496:
1467:
1460:
1433:angiogenesis
1418:
1413:
1399:
1378:residues by
1372:hydroxylated
1369:
1340:
1309:
1298:
1281:
1264:
1247:
1230:
1213:
1196:
1173:
860:Per-ARNT-Sim
842:PER-ARNT-SIM
827:
814:Lasker Award
795:
765:
761:
760:
718:
577:
496:Alt. symbols
428:
347:Alt. symbols
279:
198:Alt. symbols
130:
29:
10632:(4.11) Runt
8287:Homeodomain
7885:zinc finger
7221:subfamily 0
7201:subfamily 6
7176:subfamily 5
7139:subfamily 4
7058:subfamily 3
6954:subfamily 2
6802:subfamily 1
6769:Zinc finger
6012:Neurogenins
5580:(1.1) Basic
5183:(1): 80–4.
4714:: 169–176.
3621:(in German)
3596:(in German)
3570:(in German)
3545:(in German)
3470:Dermatology
3272:: 232–239.
3217:(1): 94–9.
1731:ChemMedChem
1622:hippocampal
1606:Acriflavine
1558:Bay 87-2243
1542:Daprodustat
1536:(FG-4592);
1444:methylation
1343:chondrocyte
1019:HIF-1a_CTAD
1011:Identifiers
900:Identifiers
868:– recruits
834:heterodimer
740:Swiss-model
630:Identifiers
599:Swiss-model
481:Identifiers
450:Swiss-model
332:Identifiers
301:Swiss-model
183:Identifiers
152:Swiss-model
42:Identifiers
10968:Categories
9165:POU domain
8305:ANTP class
8235:(2.6) WRKY
7518:GLI family
6653:(1.5) RF-X
6551:(1.4) NF-1
5462:2021-04-26
4629:10197/9767
4455:2008-10-28
3625:2020-12-04
3600:2020-12-04
3574:2020-12-04
3549:2020-12-04
3524:2020-12-04
3366:2020-12-04
2694:Physiology
1663:References
1649:Belzutifan
1550:Molidustat
1546:Desidustat
1538:Vadadustat
1534:Roxadustat
1421:glycolysis
1395:proteasome
1336:epithelium
1305:stem cells
1084:structures
941:structures
866:C-terminus
853:N-terminus
736:Structures
731:Search for
705:Other data
595:Structures
590:Search for
564:Other data
446:Structures
441:Search for
415:Other data
297:Structures
292:Search for
266:Other data
148:Structures
143:Search for
117:Other data
10952:see also
10793:Apetala 2
9447:Fork head
8127:(2.4) Cys
7329:(2.3) Cys
6061:Scleraxis
5360:233371559
5025:retracted
5017:retracted
4883:232300877
4009:Anemia".
3594:kurier.at
3500:212693280
3451:216031505
3294:196350143
2746:7 October
2677:7 October
1849:2073-4409
1800:0300-9831
1620:enhances
1612:Neurology
1566:hepatitis
1448:chromatin
1437:promoters
1357:Mechanism
1149:,
1143:,
1137:,
1042:IPR014887
824:Structure
792:Discovery
687:NM_152794
646:NCBI gene
546:NM_014862
505:NCBI gene
397:NM_001430
356:NCBI gene
248:NM_001668
207:NCBI gene
99:NM_001530
58:NCBI gene
10270:MADS box
8410:Homeobox
8322:Hox-like
8316:protoHOX
7077:Estrogen
7072:Androgen
6926:Rev-ErbA
6464:bHLH-ZIP
6439:bHLH-COE
5978:Myogenin
5436:25 April
5414:25 April
5388:25 April
5352:33888901
5303:28450910
5254:30553076
5246:27383646
5205:20395457
5197:19900484
5162:21525087
5154:16940159
5113:17933687
5078:20546646
5010:37099630
4991:19805192
4932:26513405
4875:33730333
4836:29039125
4787:29158891
4736:85532042
4728:30914315
4689:27445820
4638:26768963
4597:27454299
4540:27259535
4505:25359381
4425:17557894
4368:26181437
4333:22362605
4292:27610652
4251:22371073
4202:24900662
4153:21671859
4118:16938364
4110:26082309
4066:12671019
4031:28002958
3995:18301799
3964:25392999
3924:PLOS ONE
3905:28508936
3856:25100284
3848:28928122
3804:27650732
3752:28290095
3700:26656456
3661:17627521
3492:32163945
3443:32306525
3402:32479616
3343:30152571
3286:31299261
3251:25535360
3192:24804159
3143:26041709
3067:20444740
3018:18393939
2966:19109240
2917:78091150
2909:30872506
2862:30872525
2805:78093369
2797:30872526
2714:15304631
2645:10353251
2602:20616028
2543:26505703
2494:28234841
2445:44049779
2437:18202826
2428:11131810
2388:27125138
2361:11959990
2302:19641938
2294:12004076
2245:46626545
2237:16129688
2196:14105830
2104:33729273
2019:15015563
1916:41659164
1867:34685573
1808:24846908
1761:26997519
1712:18410568
1295:Function
1186:Protein
1101:RCSB PDB
1037:InterPro
958:RCSB PDB
872:proteins
750:InterPro
609:InterPro
460:InterPro
311:InterPro
162:InterPro
10670:RUNX1T1
10650:CBFA2T3
10645:CBFA2T2
10525:TCF/LEF
8634:NK-like
8628:metaHOX
8331:ParaHox
8272:domains
6963:COUP-TF
6437:Group F
6360:Group E
6293:Group D
6157:Group C
6107:Group B
6051:Paraxis
5916:Group A
5508:PDBe-KB
5502:PDBe-KB
5496:PDBe-KB
5490:PDBe-KB
5343:9128828
5322:Nat Med
5294:5403438
5069:3694331
4982:2764905
4959:Bibcode
4923:4864946
4827:6131113
4778:5683220
4680:4921475
4663:: 184.
4588:5096820
4548:4386269
4496:4259899
4416:1976368
4376:5817105
4242:3606899
4193:4027554
4090:Bibcode
3955:4230943
3932:Bibcode
3896:5766731
3760:9818825
3334:6238634
3242:4291638
3219:Bibcode
3183:4005494
3134:4687906
3058:2904169
3009:2474706
2957:2828263
2889:Bibcode
2881:Science
2853:7336390
2832:Bibcode
2824:Science
2775:Bibcode
2767:Science
2722:2434206
2653:4427694
2625:Bibcode
2593:2906567
2570:Bibcode
2534:5951620
2485:5327844
2329:Bibcode
2272:Bibcode
2264:Science
2188:9382818
2166:Bibcode
2139:9301332
2096:8663540
1978:7539918
1946:Bibcode
1908:7836384
1858:8533683
1752:4848768
1703:2408651
1583:de novo
1441:histone
1386:by the
1376:proline
1324:embryos
1180:Member
1170:Members
1155:
1030:PF08778
919:PF11413
778:hypoxia
746:Domains
716:Chr. 19
694:UniProt
605:Domains
553:UniProt
456:Domains
430:p21-p16
404:UniProt
307:Domains
255:UniProt
158:Domains
132:q21-q24
128:Chr. 14
106:UniProt
9383:Bicoid
8648:BARHL2
8643:BARHL1
8225:JMJD1B
8138:HIVEP1
6623:I-SMAD
6591:R-SMAD
6509:MLXIPL
6264:Period
6190:ARNTL2
5995:NeuroD
5486:(MeSH)
5358:
5350:
5340:
5301:
5291:
5252:
5244:
5203:
5195:
5160:
5152:
5111:
5076:
5066:
5008:
5004:,
4989:
4979:
4930:
4920:
4881:
4873:
4834:
4824:
4785:
4775:
4761:: 62.
4734:
4726:
4687:
4677:
4636:
4595:
4585:
4546:
4538:
4503:
4493:
4423:
4413:
4374:
4366:
4331:
4290:
4249:
4239:
4200:
4190:
4151:
4116:
4108:
4064:
4029:
3993:
3962:
3952:
3903:
3893:
3854:
3846:
3802:
3758:
3750:
3708:179020
3706:
3698:
3659:
3498:
3490:
3449:
3441:
3400:
3361:PubMed
3341:
3331:
3292:
3284:
3249:
3239:
3190:
3180:
3141:
3131:
3092:3 July
3065:
3055:
3016:
3006:
2964:
2954:
2915:
2907:
2860:
2850:
2803:
2795:
2720:
2712:
2651:
2643:
2617:Nature
2600:
2590:
2541:
2531:
2492:
2482:
2443:
2435:
2425:
2386:
2359:
2352:122775
2349:
2300:
2292:
2243:
2235:
2194:
2186:
2137:
2102:
2094:
2017:
2007:
1976:
1966:
1914:
1906:
1865:
1855:
1847:
1806:
1798:
1759:
1749:
1710:
1700:
1634:stroke
1554:anemia
1524:Anemia
1499:prolyl
1328:wounds
1277:HIF-3β
1260:HIF-3α
1243:HIF-2β
1226:HIF-2α
1209:HIF-1β
1192:HIF-1α
1116:PDBsum
1090:
1080:
1062:SUPFAM
1016:Symbol
973:PDBsum
947:
937:
905:Symbol
774:oxygen
768:) are
699:Q9Y2N7
682:RefSeq
675:609976
635:Symbol
575:Chr. 1
558:Q9HBZ2
541:RefSeq
534:606036
486:Symbol
426:Chr. 2
409:Q99814
392:RefSeq
385:603349
337:Symbol
277:Chr. 1
260:P27540
243:RefSeq
236:126110
188:Symbol
111:Q16665
94:RefSeq
87:603348
47:Symbol
10933:Sigma
10798:EREBP
10782:EREBP
10773:(0.5)
10742:(0.3)
10665:RUNX3
10660:RUNX2
10655:RUNX1
10599:TFCP2
10520:SSRP1
10341:(4.7)
10331:TBPL1
10315:(4.6)
10267:(4.4)
10117:(4.2)
10058:NFKB2
10053:NFKB1
10048:NF-κB
10037:(4.1)
9961:MYBL2
9748:(3.4)
9444:(3.3)
9393:BICD2
9368:SHOX2
9336:PROP1
9320:PRRX
9230:SATB2
9175:BRN-3
9170:PIT-1
9062:PKNOX
8977:TALE
8973:NOBOX
8946:HESX1
8919:CUTL1
8901:other
8795:NANOG
8658:BARX2
8653:BARX1
8405:MEOX2
8400:MEOX1
8284:(3.1)
8193:JARID
8166:GRLF1
8161:DIDO1
7821:Zbtb7
7811:TSHZ3
7779:PRDM9
7577:HIVEP
7442:ATBF1
7396:TFIIH
7381:TFIIF
7364:TFIIE
7359:TFIID
7354:TFIIB
7349:TFIIA
7319:TRPS1
7185:LRH-1
7163:NURR1
7153:NGFIB
6981:Ear-2
6782:(2.1)
6524:SREBP
6461:(1.3)
6223:NPAS
6212:EPAS1
6197:CLOCK
6185:ARNTL
6159:bHLH-
6135:n-Myc
6130:l-Myc
6125:c-Myc
6115:FIGLA
6097:Twist
6056:TCF15
5963:MESP2
5941:ATOH1
5934:ASCL2
5929:ASCL1
5860:NFIL3
5791:GABPA
5786:DDIT3
5717:C/EBP
5712:BLZF1
5673:c-Jun
5663:FOSL2
5658:FOSL1
5648:c-Fos
5356:S2CID
5250:S2CID
5201:S2CID
5158:S2CID
5021:with
4879:S2CID
4732:S2CID
4544:S2CID
4449:(PDF)
4442:(PDF)
4395:Blood
4372:S2CID
4114:S2CID
3852:S2CID
3756:S2CID
3704:S2CID
3496:S2CID
3447:S2CID
3290:S2CID
2913:S2CID
2801:S2CID
2718:S2CID
2649:S2CID
2441:S2CID
2298:S2CID
2241:S2CID
2192:S2CID
2100:S2CID
1969:41725
1912:S2CID
1827:Cells
1587:NF-κB
1479:siRNA
1475:NF-κB
1471:NF-κB
1351:bones
1283:ARNT3
1266:HIF3A
1249:ARNT2
1232:EPAS1
1198:HIF1A
1183:Gene
1058:SCOPe
1049:SCOP2
908:HIF-1
711:Locus
663:15825
651:64344
639:HIF3A
570:Locus
522:16876
490:ARNT2
421:Locus
341:EPAS1
272:Locus
123:Locus
51:HIF1A
18:HIF-1
10902:MNDA
10821:ARID
10776:AP-2
10763:RBL2
10758:RBL1
10732:HBP1
10715:HMGA
10622:YBX1
10617:CSDA
10552:LEF1
10384:HMGN
10357:HMGB
10278:Mef2
10257:MYRF
10245:TBR2
10240:TBR1
10188:TP63
10128:STAT
10120:STAT
10080:NFAT
10073:RELB
10068:RELA
10023:(4)
9904:FLI1
9870:SPIB
9571:D4L6
9566:D4L5
9561:D4L4
9556:D4L3
9551:D4L1
9415:PITX
9378:VSX2
9373:VSX1
9363:SHOX
9341:PHOX
9023:MEIS
8951:HOPX
8887:VAX2
8882:VAX1
8877:TLX3
8872:TLX2
8867:TLX1
8862:NATO
8845:HMX3
8840:HMX2
8835:HMX1
8773:LBX2
8768:LBX1
8758:HHEX
8617:MNX1
8612:GBX2
8607:GBX1
8395:Evx2
8390:Evx1
8358:PDX1
8353:Xlox
8243:WRKY
8156:AIRE
8115:804A
7838:ZBTB
7784:SALL
7774:OSR1
7769:MYT1
7764:MTF1
7599:IKZF
7538:REST
7513:GFI1
7508:ERV3
7476:E4F1
7471:CTCF
7260:GATA
7230:DAX1
7210:GCNF
7158:NOR1
6986:HNF4
6855:PPAR
6788:(Cys
6716:AP-2
6586:SMAD
6541:USF1
6514:MXI1
6494:MITF
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