823:
certainly a result of the abnormally efficient binding of HLA-A*02 to peptides originating from EBV. This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. This, in turn, enhances the immune system's ability to control and clear the EBV, which decreases the change of developing
Hodgkin Lymphoma as a result of the infection.
48:
785:
HLAs serve as the primary link between the immune system and interior of cells. Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility
808:
HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. This could be the reason for a documented 9-fold reduced risk of HIV transmission to infants during childbirth. HIV has evolved mechanisms to combat immune recognition. HIV produces a protein
790:
of pathogenic proteins. If HLAs bind none of the peptides produced by a pathogen, then there is no way for the immune system to tell that a cell is infected. Thus the infection can proliferate largely unchecked. It works the other way too. Some HLAs bind pathogenic peptide fragments with very high
813:
that binds to the cytoplasmic tail of HLA-A and B and diverts it to the lysosomes for destruction. This prevents the HLAs from being expressed on the cell surface and then functioning properly. In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower
668:
The serotyping for the most abundant A*02 alleles is good. For A*02:03, A*02:06, A*02:07 serotyping is borderline useful. There is a separate serotyping for A203 and A210. As of
December 2013, there are 456 alleles identified (mostly by sequence homology) as being A2, of those 27 are nulls, and a
822:
HLA-A*02 has been linked with decreased risk of developing
Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL). Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. This is a significant decrease and is almost
799:
The HLA-A*02 antigen has been associated with spontaneous abortion in infertile couples. In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. This immune
814:
viral loads in HIV patients. HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). In summation, HLA-A*02 appears to be somewhat less effective than other HLA-As at protecting against HIV infections.
659:
locus. The A*02 allele group can code for many proteins; as of
December 2013 there are 456 different HLA-A*02 proteins. Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). Genes can further be
3975:
Over northwestern Europe A2-B44 shows a single common ancestor which contributed the Cw5 allele to the haplotype. The haplotype appears to have been introduced early in
European prehistoric period, frequencies of the haplotype generally correlate with A1-Cw7-B8 and A2-B7. The haplotype is
800:
response could be compared to an allergic reaction, and, if severe enough, induces abortion of the fetus. Although this is a very interesting correlation, the study which first uncovered this link was quite small and more work needs to be done to verify this hypothesis.
4206:
Mann JK, Byakwaga H, Kuang XT, Le AQ, Brumme CJ, Mwimanzi P, Omarjee S, Martin E, Lee GQ, Baraki B, Danroth R, McCloskey R, Muzoora C, Bangsberg DR, Hunt PW, Goulder PJ, Walker BD, Harrigan PR, Martin JN, Ndung'u T, Brockman MA, Brumme ZL (16 September 2013).
660:
separated by genetic sequencing and analysis. HLAs can be identified with as many as nine numbers and a letter (ex. HLA-A*02:101:01:02N). HLA-A*02 is globally common, but particular variants of the allele can be separated by geographic prominence.
4170:
Grene E, Pinto LA, Cohen SS, Trivett MT, Simonis TB, Liewehr DJ, Steinberg SM, Shearer GM (Feb 2001). "Generation of alloantigen-stimulated anti-human immunodeficiency virus activity is associated with HLA-A*02 expression".
4522:
Grundschober C, Sanchez-Mazas A, Excoffier L, Langaney A, Jeannet M, Tiercy JM (Jun 1994). "HLA-DPB1 DNA polymorphism in the Swiss population: linkage disequilibrium with other HLA loci and population genetic affinities".
648:. In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2.
641:
serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the
791:
affinity. This in essence "supercharges" their immune system in regards to that particular pathogen, allowing them to easily control an infection that might otherwise be devastating.
3992:
Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (Feb 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin".
4460:
Finch T, Lawlor E, Borton M, Barnes CA, McNamara S, O'Riordan J, McCann SR, Darke C (1997). "Distribution of HLA-A, B and DR genes and haplotypes in the Irish population".
4487:
Middleton D, Williams F, Hamill MA, Meenagh A (Dec 2000). "Frequency of HLA-B alleles in a
Caucasoid population determined by a two-stage PCR-SSOP typing strategy".
4310:
Niens M, Jarrett RF, Hepkema B, Nolte IM, Diepstra A, Platteel M, Kouprie N, Delury CP, Gallagher A, Visser L, Poppema S, te
Meerman GJ, van den Berg A (Nov 2007).
20:
3870:
3976:
considerably more equilibrated relative to A1-B8 and a possible reason is gene flow from iberia or the east with related haplotypes after initial migrations.
4618:
4263:"Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1"
4111:
4437:
HLA 1991: proceedings of the eleventh
International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991
3905:
is the multi-serotype designation for the haplotype HLA-A*02:01~C*05:01~B*4402, the class I portion, of an ancestral haplotype (A2~B44~
4444:
4083:
619:
4373:
Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net".
652:
4127:
Komlos L, Klein T, Korostishevsky M (Aug 2007). "HLA-A2 class I antigens in couples with recurrent spontaneous abortions".
4611:
4566:
Schipper RF, Schreuder GM, D'Amaro J, Oudshoorn M (Nov 1996). "HLA gene and haplotype frequencies in Dutch blood donors".
4312:"HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma"
4375:
4604:
669:
large majority have unknown serotypes, although it is highly probable that they will all return A2 serotypes.
4261:
Tang J, Tang S, Lobashevsky E, Myracle AD, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow RA (Aug 2002).
4103:
3914:
631:
786:
to disease. In other words, certain HLAs may be incapable of binding any of the short peptides produced by
4795:
90:
4311:
4079:
615:
642:
123:
101:
4548:
4342:
4152:
600:
586:
572:
528:
514:
500:
486:
172:
4583:
4540:
4504:
4469:
4440:
4392:
4334:
4292:
4240:
4188:
4144:
4107:
4009:
4575:
4532:
4496:
4384:
4326:
4282:
4274:
4230:
4220:
4180:
4136:
4001:
3492:
3303:
3002:
2421:
2032:
1795:
1550:
4100:
The
Compatibility Gene. How Our Bodies Fight Disease, Attract Others, and Define Our Selves
4095:
114:
4579:
4536:
4235:
4209:"Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes"
4208:
4055:
4005:
4500:
4287:
4262:
4789:
4388:
4278:
4140:
810:
4552:
4346:
4156:
4330:
3946:
Another haplotype that is more common in
Central Europe is the (A2-B44-DR7-DQ2)
787:
107:
34:
4225:
4076:
3335:
3034:
2453:
2064:
1827:
1582:
857:
4508:
4396:
4338:
4296:
4244:
4192:
4148:
4587:
4544:
4473:
4630:
3595:
634:
4013:
671:
4774:
4769:
4762:
4757:
4752:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4710:
4703:
4698:
4693:
4688:
4683:
4678:
4671:
4666:
3910:
3906:
3586:
85:
645:
473:
467:
461:
455:
449:
443:
437:
431:
425:
419:
413:
407:
401:
395:
389:
383:
377:
371:
365:
359:
353:
347:
341:
335:
329:
323:
317:
311:
305:
299:
293:
287:
281:
275:
269:
263:
257:
251:
245:
239:
233:
227:
221:
215:
209:
203:
197:
191:
185:
179:
54:
4661:
4656:
4651:
4646:
94:
4184:
4641:
4627:
4596:
656:
638:
119:
47:
38:
831:
A*02:Cw*16 is associated with increased higher viral load in HIV
16:
Human leukocyte antigen serotype within the HLA-A serotype group
4600:
3550:
A2-B46 (Node in Southern China, may be most abundant haplotype)
21:
History and naming of human leukocyte antigens § Genetics
4435:
Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992).
4030:
3913:). The full haplotype is (for relative distances) see
4430:
4428:
4426:
4424:
4422:
4420:
4418:
4416:
4414:
4412:
4410:
4408:
4406:
3478:
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3462:
3454:
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3438:
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3422:
3414:
3406:
3398:
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3331:
3289:
3281:
3273:
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3257:
3249:
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3225:
3217:
3209:
3201:
3193:
3185:
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3145:
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3129:
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3105:
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2892:
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2796:
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2620:
2612:
2604:
2596:
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2532:
2524:
2516:
2508:
2500:
2492:
2484:
2476:
2468:
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2449:
2407:
2399:
2391:
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2375:
2367:
2359:
2351:
2343:
2335:
2327:
2319:
2311:
2303:
2295:
2287:
2279:
2271:
2263:
2255:
2247:
2239:
2231:
2223:
2215:
2207:
2199:
2191:
2183:
2175:
2167:
2159:
2151:
2143:
2135:
2127:
2119:
2111:
2103:
2095:
2087:
2079:
2075:
2060:
2018:
2010:
2002:
1994:
1986:
1978:
1970:
1962:
1954:
1946:
1938:
1930:
1922:
1914:
1906:
1898:
1890:
1882:
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1823:
1781:
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1749:
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1709:
1701:
1693:
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1677:
1669:
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1653:
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1637:
1629:
1621:
1613:
1605:
1597:
1593:
1578:
1536:
1528:
1520:
1512:
1504:
1496:
1488:
1480:
1472:
1464:
1456:
1448:
1440:
1432:
1424:
1416:
1408:
1400:
1392:
1384:
1376:
1368:
1360:
1352:
1344:
1336:
1328:
1320:
1312:
1304:
1296:
1288:
1280:
1272:
1264:
1256:
1248:
1240:
1232:
1224:
1216:
1208:
1200:
1192:
1184:
1176:
1168:
1160:
1152:
1144:
1136:
1128:
1120:
1112:
1104:
1096:
1088:
1080:
1072:
1064:
1056:
1048:
1040:
1032:
1024:
1016:
1008:
1000:
992:
984:
976:
968:
960:
952:
944:
936:
928:
920:
912:
904:
896:
888:
880:
872:
868:
853:
595:
581:
567:
550:
541:
523:
509:
495:
481:
167:
150:
141:
133:
113:
100:
84:
79:
27:
4025:
4023:
4368:
4366:
4364:
4362:
4360:
4358:
4356:
4033:. Anthony Nolan Research Institute. 10 Nov 2013
3573:A2-B37 A2-B39 (Node in North American Amerinds)
4256:
4254:
673:A2 recognition of some HLA A*02 gene products
4612:
4058:. European Molecular Biology Laboratory. 2013
4050:
4048:
8:
3326:
3025:
2444:
2055:
1818:
1573:
848:
4619:
4605:
4597:
3316:
3015:
2434:
2045:
1808:
1563:
838:
547:
147:
46:
4286:
4234:
4224:
4462:Experimental and Clinical Immunogenetics
4129:International Journal of Immunogenetics
3984:
3325:
3024:
2443:
2054:
1817:
1572:
847:
24:
7:
4439:. Oxford : Oxford University Press.
4031:"HLA Nomenclature @ hla.alleles.org"
3511:A2-B7 (Node in Netherlands) A2-B5
651:HLA-A*02 is one particular class I
4580:10.1111/j.1399-0039.1996.tb02670.x
4537:10.1111/j.1744-313X.1994.tb00186.x
4525:European Journal of Immunogenetics
4173:The Journal of Infectious Diseases
4006:10.1111/j.1399-0039.1978.tb01233.x
14:
4084:European Bioinformatics Institute
3597:HLA A2-B44 haplotype frequencies
4389:10.1034/j.1399-0039.2003.00062.x
4279:10.1128/JVI.76.16.8276-8284.2002
4141:10.1111/j.1744-313X.2007.00682.x
653:major histocompatibility complex
3558:
1:
4501:10.1016/S0198-8859(00)00186-5
3439:Singapore Javanese Indonesian
3290:Singapore Javanese Indonesian
3250:China Tibet Autonomous Region
1883:Singapore Javanese Indonesian
1409:Singapore Javanese Indonesian
4331:10.1182/blood-2007-05-086934
3383:Sri Lanka Colombo Sinhale...
3367:India Andhra Pradesh Goll...
2917:Singapore Javanese Indone...
2877:Papua New Guinea Eastern ...
2861:India Andhra Pradesh Goll...
2717:China Beijing Shijiazhuan...
2701:USA New Mexico Canoncito ...
2629:USA North American Native...
2557:USA South Dakota Lakota S...
2541:Mexico Chihuahua State Ta...
2408:Spain Basque Gipuzkoa Pro...
2104:Saudi Arabia Guraiat and ...
1702:Saudi Arabia Guraiat and ...
1425:India Andhra Pradesh Goll...
1193:Australia Indig. Cape Yor...
1121:Venezuela Perja Mountain ...
1097:USA North American Native...
1057:Mexico Chihuahua State Ta...
1009:Spain Basque Gipuzkoa Pro...
945:USA South Dakota Lakota S...
889:USA New Mexico Canoncito ...
804:Human immunodeficiency virus
2893:Sri Lanka Colombo Sinhalese
2328:Georgia Tbilisi Georgian...
1995:Sri Lanka Colombo Sinhalese
1774:Georgia Tbilisi Georgian...
1393:Sri Lanka Colombo Sinhalese
913:Georgia Tbilisi Georgian...
4812:
3883:
3873:
3856:
3842:
3828:
3813:
3798:
3783:
3768:
3753:
3738:
3723:
3708:
3693:
3678:
3663:
3648:
3633:
3618:
1081:Mexico Guadalajara Mestizo
655:(MHC) allele group at the
18:
4637:
3895:
3490:
3486:
3320:A*02:11 allele frequency
3301:
3297:
3019:A*02:07 allele frequency
3000:
2996:
2909:Papua New Guinea Wanigela
2621:USA South Texas Hispanics
2438:A*02:06 allele frequency
2419:
2415:
2368:Senegal Niokholo Mandenka
2312:USA African Americans (2)
2049:A*02:05 allele frequency
2030:
2026:
1812:A*02:03 allele frequency
1793:
1789:
1670:USA African Americans (2)
1606:Senegal Niokholo Mandenka
1567:A*02:02 allele frequency
1548:
1544:
1329:Senegal Niokholo Mandenka
1257:USA African Americans (3)
1105:USA South Texas Hispanics
1033:Australia New South Wales
842:A*02:01 allele frequency
613:
562:Available structures
546:
162:Available structures
146:
45:
32:
4226:10.1186/1742-4690-10-100
3915:Human leukocyte antigens
3359:South Africa Natal Tamil
2517:USA Alaska Yupik Natives
2120:South African Natal Zulu
1686:South African Natal Zulu
1537:South Africa Natal Tamil
1489:USA Alaska Yupik Natives
1473:South African Natal Zulu
60:α (A*02:01 gene product)
4104:Oxford University Press
3026:HLA A*02:07 frequencies
2445:HLA A*02:06 frequencies
2056:HLA A*02:05 frequencies
1819:HLA A*02:03 frequencies
1574:HLA A*02:02 frequencies
849:HLA A*02:01 frequencies
632:human leukocyte antigen
3327:HLA A*0211 frequencies
2989:Pakistan Karachi Parsi
2509:Japan Okinawa Ryukyuan
2477:Mexico Zaptotec Oaxaca
2264:Spain Catalonia Girona
1750:Pakistan Karachi Parsi
1457:Pakistan Karachi Parsi
1281:Japan Okinawa Ryukyuan
1273:India Tamil Nadu Nadar
969:Mexico Zaptotec Oaxaca
937:Spain Catalonia Girona
91:transmembrane receptor
3375:India Mumbai Marathas
3090:Singapore Chinese Han
2685:Singapore Chinese Han
2184:Zimbabwe Harare Shona
2136:Georgia Tbilisi Kurds
1971:India Mumbai Marathas
1678:Zimbabwe Harare Shona
1662:Georgia Svaneti Svans
1521:India Mumbai Marathas
1313:Georgia Tbilisi Kurds
1289:Zimbabwe Harare Shona
1129:Georgia Svaneti Svans
41:cell surface antigen)
4056:"Allele Search Tool"
3463:Singapore Riau Malay
3351:India Khandesh Pawra
3234:Singapore Riau Malay
3210:China Inner Mongolia
3058:China Guangxi Maonan
2925:Singapore Riau Malay
2733:China Guangxi Maonan
2485:Mexico Mixtec Oaxaca
2392:Mexico Mixtec Oaxaca
2144:Burkina Faso Rimaibe
2011:Burkina Faso Rimaibe
1939:India Khandesh Pawra
1931:Singapore Riau Malay
1843:China Guangxi Maonan
1646:Burkina Faso Rimaibe
1401:China Guangxi Maonan
1345:Singapore Riau Malay
1233:Burkina Faso Rimaibe
1185:Morocco Nador Berber
795:Spontaneous abortion
781:Disease associations
614:Alleles link-out to
4267:Journal of Virology
3598:
3328:
3282:Japan Ainu Hokkaido
3274:Burkina Faso Fulani
3098:Taiwan Minnan pop 1
3027:
2845:Taiwan Minnan pop 1
2501:Japan Ainu Hokkaido
2446:
2200:USA African America
2128:Cameroon Pygmy Baka
2080:Burkina Faso Fulani
2057:
1907:Taiwan Minnan pop 1
1820:
1575:
1385:Burkina Faso Fulani
1153:Japan Ainu Hokkaido
850:
674:
3596:
3493:Allele frequencies
3391:India North Hindus
3304:Allele frequencies
3266:USA Hawaii Okinawa
3050:Thailand Northeast
3003:Allele frequencies
2837:India North Hindus
2757:Philippines Ivatan
2525:USA Hawaii Okinawa
2469:Mexico Mixe Oaxaca
2422:Allele frequencies
2384:India North Hindus
2376:USA Caucasians (3)
2033:Allele frequencies
1859:Thailand Northeast
1796:Allele frequencies
1551:Allele frequencies
1353:India North Hindus
929:Philippines Ivatan
873:Mexico Sonora Seri
672:
4783:
4782:
4113:978-0-19-931641-0
4077:Allele Query Form
3900:
3899:
3754:Dutch Netherlands
3504:
3503:
3500:
3499:
3496:
3447:India North Delhi
3342:
3315:
3314:
3311:
3310:
3307:
3258:Russia Tuva pop 2
3218:China Yunnan Lisu
3186:China Qinghai Hui
3074:Singapore Chinese
3066:Hong Kong Chinese
3041:
3014:
3013:
3010:
3009:
3006:
2765:Singapore Chinese
2725:Hong Kong Chinese
2653:Russia Tuva pop 2
2645:South Korea pop 3
2589:India North Delhi
2460:
2433:
2432:
2429:
2428:
2425:
2360:India North Delhi
2216:Cameroon Bamileke
2152:Israel Arab Druse
2071:
2044:
2043:
2040:
2039:
2036:
2003:China Qinghai Hui
1851:China Yunnan Lisu
1834:
1807:
1806:
1803:
1802:
1799:
1758:China Qinghai Hui
1742:India North Delhi
1726:Israel Arab Druse
1598:Cameroon Bamileke
1589:
1562:
1561:
1558:
1557:
1554:
1001:USA Caucasian (2)
961:Italy North pop 1
864:
778:
777:
625:
624:
609:
608:
537:
536:
4803:
4621:
4614:
4607:
4598:
4592:
4591:
4563:
4557:
4556:
4519:
4513:
4512:
4489:Human Immunology
4484:
4478:
4477:
4457:
4451:
4450:
4432:
4401:
4400:
4370:
4351:
4350:
4316:
4307:
4301:
4300:
4290:
4258:
4249:
4248:
4238:
4228:
4203:
4197:
4196:
4167:
4161:
4160:
4124:
4118:
4117:
4092:
4086:
4074:
4068:
4067:
4065:
4063:
4052:
4043:
4042:
4040:
4038:
4027:
4018:
4017:
3989:
3972:
3968:
3964:
3960:
3956:
3952:
3943:
3939:
3935:
3931:
3927:
3923:
3664:Northern Ireland
3599:
3491:
3479:Pakistan Burusho
3407:India West Bhils
3340:
3332:Study population
3329:
3317:
3302:
3039:
3031:Study population
3028:
3016:
3001:
2669:Pakistan Burusho
2605:USA Arizona Pima
2458:
2450:Study population
2447:
2435:
2420:
2344:Ireland Northern
2272:Cameroon Yaounde
2069:
2061:Study population
2058:
2046:
2031:
1947:India West Bhils
1832:
1824:Study population
1821:
1809:
1794:
1614:Cameroon Yaounde
1587:
1579:Study population
1576:
1564:
1549:
1337:Cameroon Yaounde
993:Ireland Northern
881:USA Arizona Pima
862:
854:Study population
851:
839:
818:Hodgkin lymphoma
675:
603:
589:
575:
548:
531:
517:
503:
489:
476:
470:
464:
458:
452:
446:
440:
434:
428:
422:
416:
410:
404:
398:
392:
386:
380:
374:
368:
362:
356:
350:
344:
338:
332:
326:
320:
314:
308:
302:
296:
290:
284:
278:
272:
266:
260:
254:
248:
242:
236:
230:
224:
218:
212:
206:
200:
194:
188:
182:
175:
148:
73:
69:
61:
57:
50:
25:
4811:
4810:
4806:
4805:
4804:
4802:
4801:
4800:
4786:
4785:
4784:
4779:
4633:
4625:
4595:
4568:Tissue Antigens
4565:
4564:
4560:
4521:
4520:
4516:
4495:(12): 1285–97.
4486:
4485:
4481:
4459:
4458:
4454:
4447:
4434:
4433:
4404:
4376:Tissue Antigens
4372:
4371:
4354:
4314:
4309:
4308:
4304:
4273:(16): 8276–84.
4260:
4259:
4252:
4205:
4204:
4200:
4169:
4168:
4164:
4126:
4125:
4121:
4114:
4096:Daniel M. Davis
4094:
4093:
4089:
4075:
4071:
4061:
4059:
4054:
4053:
4046:
4036:
4034:
4029:
4028:
4021:
3994:Tissue Antigens
3991:
3990:
3986:
3982:
3970:
3966:
3962:
3958:
3954:
3950:
3941:
3937:
3933:
3929:
3925:
3921:
3896:Cw*0501 (Eur.)
3594:
3574:
3572:
3570:
3568:
3547:A2-B70,71,75,76
3525:
3523:
3509:
3507:A2-B haplotypes
3495:presented, only
3455:Pakistan Baloch
3431:Pakistan Pathan
3423:Pakistan Brahui
3415:Pakistan Sindhi
3338:
3306:presented, only
3226:Mongolia Buriat
3202:South Korea (3)
3178:China North Han
3130:China Yunnan Nu
3122:China Guangzhou
3114:China South Han
3037:
3005:presented, only
2957:Pakistan Baloch
2901:Pakistan Brahui
2821:India New Delhi
2813:Pakistan Pathan
2797:Pakistan Sindhi
2781:China South Han
2749:China Guangzhou
2741:Mongolia Buriat
2661:Mexico Mestizos
2637:China North Han
2493:Pakistan Kalash
2456:
2424:presented, only
2400:Portugal Centre
2320:China North Han
2280:Mali Bandiagara
2232:Pakistan Sindhi
2192:India New Delhi
2176:Mongolia Buriat
2112:Italy North (1)
2067:
2035:presented, only
1987:China North Han
1891:China Yunnan Nu
1875:China Guangzhou
1867:China South Han
1830:
1798:presented, only
1710:Pakistan Brahui
1622:Mali Bandiagara
1585:
1553:presented, only
1377:China South Han
1321:Mali Bandiagara
1225:Mongolia Buriat
1217:South Korea (3)
1041:Portugal Centre
905:Mexico Mestizos
860:
837:
829:
820:
806:
797:
783:
666:
599:
585:
571:
563:
558:
553:
527:
513:
499:
485:
472:
466:
460:
454:
448:
442:
436:
430:
424:
418:
412:
406:
400:
394:
388:
382:
376:
370:
364:
358:
352:
346:
340:
334:
328:
322:
316:
310:
304:
298:
292:
286:
280:
274:
268:
262:
256:
250:
244:
238:
232:
226:
220:
214:
208:
202:
196:
190:
184:
178:
171:
163:
158:
153:
127:
75:
71:
67:
63:
59:
53:
23:
17:
12:
11:
5:
4809:
4807:
4799:
4798:
4788:
4787:
4781:
4780:
4778:
4777:
4772:
4767:
4766:
4765:
4760:
4750:
4749:
4748:
4743:
4738:
4733:
4728:
4723:
4713:
4708:
4707:
4706:
4701:
4696:
4691:
4686:
4676:
4675:
4674:
4669:
4659:
4654:
4649:
4644:
4638:
4635:
4634:
4626:
4624:
4623:
4616:
4609:
4601:
4594:
4593:
4558:
4514:
4479:
4452:
4445:
4402:
4383:(5): 403–407.
4352:
4302:
4250:
4198:
4185:10.1086/318085
4162:
4119:
4112:
4087:
4069:
4044:
4019:
3983:
3981:
3978:
3898:
3897:
3893:
3892:
3890:
3888:
3885:
3882:
3879:
3878:
3875:
3872:
3867:
3866:
3863:
3861:
3858:
3855:
3852:
3851:
3849:
3847:
3844:
3841:
3838:
3837:
3835:
3833:
3830:
3827:
3824:
3823:
3820:
3818:
3815:
3812:
3809:
3808:
3805:
3803:
3800:
3797:
3794:
3793:
3790:
3788:
3785:
3782:
3779:
3778:
3775:
3773:
3770:
3767:
3764:
3763:
3760:
3758:
3755:
3752:
3749:
3748:
3745:
3743:
3740:
3737:
3734:
3733:
3730:
3728:
3725:
3722:
3719:
3718:
3715:
3713:
3710:
3707:
3704:
3703:
3700:
3698:
3695:
3692:
3689:
3688:
3685:
3683:
3680:
3677:
3674:
3673:
3670:
3668:
3665:
3662:
3659:
3658:
3655:
3653:
3650:
3647:
3644:
3643:
3640:
3638:
3635:
3632:
3629:
3628:
3625:
3623:
3620:
3617:
3613:
3612:
3609:
3607:
3604:
3602:
3593:
3590:
3584:
3583:
3580:
3565:
3564:
3561:
3552:
3551:
3548:
3545:
3542:
3535:
3534:
3531:
3520:
3519:
3516:
3508:
3505:
3502:
3501:
3498:
3497:
3488:
3487:
3484:
3483:
3480:
3476:
3475:
3472:
3468:
3467:
3464:
3460:
3459:
3456:
3452:
3451:
3448:
3444:
3443:
3440:
3436:
3435:
3432:
3428:
3427:
3424:
3420:
3419:
3416:
3412:
3411:
3408:
3404:
3403:
3400:
3399:Ecuador Cayapa
3396:
3395:
3392:
3388:
3387:
3384:
3380:
3379:
3376:
3372:
3371:
3368:
3364:
3363:
3360:
3356:
3355:
3352:
3348:
3347:
3344:
3343:
3333:
3322:
3321:
3313:
3312:
3309:
3308:
3299:
3298:
3295:
3294:
3291:
3287:
3286:
3283:
3279:
3278:
3275:
3271:
3270:
3267:
3263:
3262:
3259:
3255:
3254:
3251:
3247:
3246:
3243:
3239:
3238:
3235:
3231:
3230:
3227:
3223:
3222:
3219:
3215:
3214:
3211:
3207:
3206:
3203:
3199:
3198:
3195:
3191:
3190:
3187:
3183:
3182:
3179:
3175:
3174:
3171:
3167:
3166:
3163:
3159:
3158:
3155:
3151:
3150:
3147:
3143:
3142:
3139:
3135:
3134:
3131:
3127:
3126:
3123:
3119:
3118:
3115:
3111:
3110:
3107:
3103:
3102:
3099:
3095:
3094:
3091:
3087:
3086:
3083:
3082:Singapore Thai
3079:
3078:
3075:
3071:
3070:
3067:
3063:
3062:
3059:
3055:
3054:
3051:
3047:
3046:
3043:
3042:
3032:
3021:
3020:
3012:
3011:
3008:
3007:
2998:
2997:
2994:
2993:
2990:
2986:
2985:
2982:
2978:
2977:
2974:
2970:
2969:
2966:
2962:
2961:
2958:
2954:
2953:
2950:
2946:
2945:
2942:
2941:Taiwan Saisiat
2938:
2937:
2934:
2933:Singapore Thai
2930:
2929:
2926:
2922:
2921:
2918:
2914:
2913:
2910:
2906:
2905:
2902:
2898:
2897:
2894:
2890:
2889:
2886:
2882:
2881:
2878:
2874:
2873:
2870:
2866:
2865:
2862:
2858:
2857:
2854:
2850:
2849:
2846:
2842:
2841:
2838:
2834:
2833:
2830:
2826:
2825:
2822:
2818:
2817:
2814:
2810:
2809:
2806:
2802:
2801:
2798:
2794:
2793:
2790:
2786:
2785:
2782:
2778:
2777:
2774:
2770:
2769:
2766:
2762:
2761:
2758:
2754:
2753:
2750:
2746:
2745:
2742:
2738:
2737:
2734:
2730:
2729:
2726:
2722:
2721:
2718:
2714:
2713:
2710:
2706:
2705:
2702:
2698:
2697:
2694:
2690:
2689:
2686:
2682:
2681:
2678:
2674:
2673:
2670:
2666:
2665:
2662:
2658:
2657:
2654:
2650:
2649:
2646:
2642:
2641:
2638:
2634:
2633:
2630:
2626:
2625:
2622:
2618:
2617:
2614:
2610:
2609:
2606:
2602:
2601:
2598:
2594:
2593:
2590:
2586:
2585:
2582:
2578:
2577:
2574:
2570:
2569:
2566:
2562:
2561:
2558:
2554:
2553:
2550:
2546:
2545:
2542:
2538:
2537:
2534:
2533:American Samoa
2530:
2529:
2526:
2522:
2521:
2518:
2514:
2513:
2510:
2506:
2505:
2502:
2498:
2497:
2494:
2490:
2489:
2486:
2482:
2481:
2478:
2474:
2473:
2470:
2466:
2465:
2462:
2461:
2451:
2440:
2439:
2431:
2430:
2427:
2426:
2417:
2416:
2413:
2412:
2409:
2405:
2404:
2401:
2397:
2396:
2393:
2389:
2388:
2385:
2381:
2380:
2377:
2373:
2372:
2369:
2365:
2364:
2361:
2357:
2356:
2353:
2349:
2348:
2345:
2341:
2340:
2337:
2333:
2332:
2329:
2325:
2324:
2321:
2317:
2316:
2313:
2309:
2308:
2305:
2301:
2300:
2297:
2293:
2292:
2289:
2288:Uganda Kampala
2285:
2284:
2281:
2277:
2276:
2273:
2269:
2268:
2265:
2261:
2260:
2257:
2256:Czech Republic
2253:
2252:
2249:
2245:
2244:
2241:
2237:
2236:
2233:
2229:
2228:
2225:
2221:
2220:
2217:
2213:
2212:
2209:
2205:
2204:
2201:
2197:
2196:
2193:
2189:
2188:
2185:
2181:
2180:
2177:
2173:
2172:
2169:
2165:
2164:
2161:
2157:
2156:
2153:
2149:
2148:
2145:
2141:
2140:
2137:
2133:
2132:
2129:
2125:
2124:
2121:
2117:
2116:
2113:
2109:
2108:
2105:
2101:
2100:
2097:
2093:
2092:
2089:
2085:
2084:
2081:
2077:
2076:
2073:
2072:
2062:
2051:
2050:
2042:
2041:
2038:
2037:
2028:
2027:
2024:
2023:
2020:
2019:Taiwan Saisiat
2016:
2015:
2012:
2008:
2007:
2004:
2000:
1999:
1996:
1992:
1991:
1988:
1984:
1983:
1980:
1976:
1975:
1972:
1968:
1967:
1964:
1960:
1959:
1956:
1952:
1951:
1948:
1944:
1943:
1940:
1936:
1935:
1932:
1928:
1927:
1924:
1920:
1919:
1916:
1912:
1911:
1908:
1904:
1903:
1900:
1896:
1895:
1892:
1888:
1887:
1884:
1880:
1879:
1876:
1872:
1871:
1868:
1864:
1863:
1860:
1856:
1855:
1852:
1848:
1847:
1844:
1840:
1839:
1836:
1835:
1825:
1814:
1813:
1805:
1804:
1801:
1800:
1791:
1790:
1787:
1786:
1783:
1779:
1778:
1775:
1771:
1770:
1767:
1766:Portugal North
1763:
1762:
1759:
1755:
1754:
1751:
1747:
1746:
1743:
1739:
1738:
1735:
1731:
1730:
1727:
1723:
1722:
1719:
1715:
1714:
1711:
1707:
1706:
1703:
1699:
1698:
1695:
1694:Uganda Kampala
1691:
1690:
1687:
1683:
1682:
1679:
1675:
1674:
1671:
1667:
1666:
1663:
1659:
1658:
1655:
1651:
1650:
1647:
1643:
1642:
1639:
1635:
1634:
1631:
1627:
1626:
1623:
1619:
1618:
1615:
1611:
1610:
1607:
1603:
1602:
1599:
1595:
1594:
1591:
1590:
1580:
1569:
1568:
1560:
1559:
1556:
1555:
1546:
1545:
1542:
1541:
1538:
1534:
1533:
1530:
1526:
1525:
1522:
1518:
1517:
1514:
1510:
1509:
1506:
1502:
1501:
1498:
1494:
1493:
1490:
1486:
1485:
1482:
1478:
1477:
1474:
1470:
1469:
1466:
1462:
1461:
1458:
1454:
1453:
1450:
1446:
1445:
1442:
1438:
1437:
1434:
1433:Singapore Thai
1430:
1429:
1426:
1422:
1421:
1418:
1414:
1413:
1410:
1406:
1405:
1402:
1398:
1397:
1394:
1390:
1389:
1386:
1382:
1381:
1378:
1374:
1373:
1370:
1366:
1365:
1362:
1358:
1357:
1354:
1350:
1349:
1346:
1342:
1341:
1338:
1334:
1333:
1330:
1326:
1325:
1322:
1318:
1317:
1314:
1310:
1309:
1306:
1302:
1301:
1298:
1297:Ecuador Cayapa
1294:
1293:
1290:
1286:
1285:
1282:
1278:
1277:
1274:
1270:
1269:
1266:
1262:
1261:
1258:
1254:
1253:
1250:
1246:
1245:
1242:
1238:
1237:
1234:
1230:
1229:
1226:
1222:
1221:
1218:
1214:
1213:
1210:
1206:
1205:
1202:
1198:
1197:
1194:
1190:
1189:
1186:
1182:
1181:
1178:
1177:Uganda Kampala
1174:
1173:
1170:
1166:
1165:
1162:
1158:
1157:
1154:
1150:
1149:
1146:
1142:
1141:
1138:
1134:
1133:
1130:
1126:
1125:
1122:
1118:
1117:
1114:
1110:
1109:
1106:
1102:
1101:
1098:
1094:
1093:
1090:
1086:
1085:
1082:
1078:
1077:
1074:
1070:
1069:
1066:
1062:
1061:
1058:
1054:
1053:
1050:
1046:
1045:
1042:
1038:
1037:
1034:
1030:
1029:
1026:
1022:
1021:
1018:
1014:
1013:
1010:
1006:
1005:
1002:
998:
997:
994:
990:
989:
986:
985:Czech Republic
982:
981:
978:
974:
973:
970:
966:
965:
962:
958:
957:
954:
953:Portugal North
950:
949:
946:
942:
941:
938:
934:
933:
930:
926:
925:
922:
918:
917:
914:
910:
909:
906:
902:
901:
898:
894:
893:
890:
886:
885:
882:
878:
877:
874:
870:
869:
866:
865:
855:
844:
843:
836:
833:
828:
825:
819:
816:
805:
802:
796:
793:
782:
779:
776:
775:
772:
769:
765:
764:
761:
758:
754:
753:
750:
747:
743:
742:
739:
736:
732:
731:
728:
725:
721:
720:
717:
714:
710:
709:
706:
703:
699:
698:
695:
692:
688:
687:
684:
679:
665:
662:
623:
622:
611:
610:
607:
606:
604:
597:
593:
592:
590:
583:
579:
578:
576:
569:
565:
564:
561:
559:
556:
554:
551:
544:
543:
539:
538:
535:
534:
532:
525:
521:
520:
518:
511:
507:
506:
504:
497:
493:
492:
490:
483:
479:
478:
176:
169:
165:
164:
161:
159:
156:
154:
151:
144:
143:
139:
138:
135:
131:
130:
128:-microglobulin
125:
117:
111:
110:
104:
98:
97:
88:
82:
81:
77:
76:
68:-microglobulin
65:
51:
43:
42:
30:
29:
15:
13:
10:
9:
6:
4:
3:
2:
4808:
4797:
4796:HLA-A alleles
4794:
4793:
4791:
4776:
4773:
4771:
4768:
4764:
4761:
4759:
4756:
4755:
4754:
4751:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4718:
4717:
4714:
4712:
4709:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4681:
4680:
4677:
4673:
4670:
4668:
4665:
4664:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4639:
4636:
4632:
4629:
4622:
4617:
4615:
4610:
4608:
4603:
4602:
4599:
4589:
4585:
4581:
4577:
4574:(5): 562–74.
4573:
4569:
4562:
4559:
4554:
4550:
4546:
4542:
4538:
4534:
4531:(3): 143–57.
4530:
4526:
4518:
4515:
4510:
4506:
4502:
4498:
4494:
4490:
4483:
4480:
4475:
4471:
4468:(4): 250–63.
4467:
4463:
4456:
4453:
4448:
4446:0-19-262390-7
4442:
4438:
4431:
4429:
4427:
4425:
4423:
4421:
4419:
4417:
4415:
4413:
4411:
4409:
4407:
4403:
4398:
4394:
4390:
4386:
4382:
4378:
4377:
4369:
4367:
4365:
4363:
4361:
4359:
4357:
4353:
4348:
4344:
4340:
4336:
4332:
4328:
4325:(9): 3310–5.
4324:
4320:
4313:
4306:
4303:
4298:
4294:
4289:
4284:
4280:
4276:
4272:
4268:
4264:
4257:
4255:
4251:
4246:
4242:
4237:
4232:
4227:
4222:
4218:
4214:
4213:Retrovirology
4210:
4202:
4199:
4194:
4190:
4186:
4182:
4179:(3): 409–16.
4178:
4174:
4166:
4163:
4158:
4154:
4150:
4146:
4142:
4138:
4134:
4130:
4123:
4120:
4115:
4109:
4105:
4101:
4097:
4091:
4088:
4085:
4081:
4078:
4073:
4070:
4057:
4051:
4049:
4045:
4032:
4026:
4024:
4020:
4015:
4011:
4007:
4003:
4000:(2): 96–112.
3999:
3995:
3988:
3985:
3979:
3977:
3973:
3947:
3944:
3918:
3916:
3912:
3908:
3904:
3894:
3891:
3889:
3886:
3881:
3880:
3876:
3871:
3869:
3868:
3864:
3862:
3859:
3854:
3853:
3850:
3848:
3845:
3840:
3839:
3836:
3834:
3831:
3826:
3825:
3821:
3819:
3816:
3811:
3810:
3806:
3804:
3801:
3796:
3795:
3791:
3789:
3786:
3781:
3780:
3776:
3774:
3771:
3766:
3765:
3761:
3759:
3756:
3751:
3750:
3746:
3744:
3741:
3736:
3735:
3731:
3729:
3726:
3721:
3720:
3716:
3714:
3711:
3706:
3705:
3701:
3699:
3696:
3691:
3690:
3686:
3684:
3681:
3676:
3675:
3671:
3669:
3666:
3661:
3660:
3656:
3654:
3651:
3646:
3645:
3641:
3639:
3636:
3631:
3630:
3626:
3624:
3621:
3615:
3614:
3610:
3608:
3605:
3603:
3601:
3600:
3591:
3589:
3588:
3581:
3578:
3577:
3576:
3562:
3560:
3557:
3556:
3555:
3549:
3546:
3543:
3540:
3539:
3538:
3532:
3529:
3528:
3527:
3517:
3514:
3513:
3512:
3506:
3494:
3489:
3485:
3481:
3477:
3473:
3469:
3465:
3461:
3457:
3453:
3449:
3445:
3441:
3437:
3433:
3429:
3425:
3421:
3417:
3413:
3409:
3405:
3401:
3397:
3393:
3389:
3385:
3381:
3377:
3373:
3369:
3365:
3361:
3357:
3353:
3349:
3345:
3337:
3334:
3330:
3324:
3323:
3319:
3318:
3305:
3300:
3296:
3292:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3260:
3256:
3252:
3248:
3244:
3240:
3236:
3232:
3228:
3224:
3220:
3216:
3212:
3208:
3204:
3200:
3196:
3192:
3188:
3184:
3180:
3176:
3172:
3168:
3164:
3160:
3156:
3154:China Beijing
3152:
3148:
3146:Taiwan Siraya
3144:
3140:
3136:
3132:
3128:
3124:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3060:
3056:
3052:
3048:
3044:
3036:
3033:
3029:
3023:
3022:
3018:
3017:
3004:
2999:
2995:
2991:
2987:
2983:
2979:
2975:
2973:Zambia Lusaka
2971:
2967:
2963:
2959:
2955:
2951:
2949:Taiwan Siraya
2947:
2943:
2939:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2891:
2887:
2883:
2879:
2875:
2871:
2867:
2863:
2859:
2855:
2853:Taiwan Paiwan
2851:
2847:
2843:
2839:
2835:
2831:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2771:
2767:
2763:
2759:
2755:
2751:
2747:
2743:
2739:
2735:
2731:
2727:
2723:
2719:
2715:
2711:
2709:China Beijing
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2679:
2677:Taiwan Taroko
2675:
2671:
2667:
2663:
2659:
2655:
2651:
2647:
2643:
2639:
2635:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2603:
2599:
2597:Japan Central
2595:
2591:
2587:
2583:
2579:
2575:
2571:
2567:
2565:Taiwan Atayal
2563:
2559:
2555:
2551:
2549:Taiwan Puyuma
2547:
2543:
2539:
2535:
2531:
2527:
2523:
2519:
2515:
2511:
2507:
2503:
2499:
2495:
2491:
2487:
2483:
2479:
2475:
2471:
2467:
2463:
2455:
2452:
2448:
2442:
2441:
2437:
2436:
2423:
2418:
2414:
2410:
2406:
2402:
2398:
2394:
2390:
2386:
2382:
2378:
2374:
2370:
2366:
2362:
2358:
2354:
2352:Cameroon Beti
2350:
2346:
2342:
2338:
2334:
2330:
2326:
2322:
2318:
2314:
2310:
2306:
2302:
2298:
2296:Italy Bergamo
2294:
2290:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2248:Cuban Mulatto
2246:
2242:
2238:
2234:
2230:
2226:
2222:
2218:
2214:
2210:
2206:
2202:
2198:
2194:
2190:
2186:
2182:
2178:
2174:
2170:
2166:
2162:
2160:Cameroon Sawa
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2130:
2126:
2122:
2118:
2114:
2110:
2106:
2102:
2098:
2094:
2090:
2086:
2082:
2078:
2074:
2066:
2063:
2059:
2053:
2052:
2048:
2047:
2034:
2029:
2025:
2021:
2017:
2013:
2009:
2005:
2001:
1997:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1923:Taiwan Siraya
1921:
1917:
1915:Taiwan Puyuma
1913:
1909:
1905:
1901:
1897:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1829:
1826:
1822:
1816:
1815:
1811:
1810:
1797:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1732:
1728:
1724:
1720:
1718:Zambia Lusaka
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
1648:
1644:
1640:
1638:Cameroon Beti
1636:
1632:
1630:Guinea Bissau
1628:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1584:
1581:
1577:
1571:
1570:
1566:
1565:
1552:
1547:
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1505:Taiwan Puyuma
1503:
1499:
1495:
1491:
1487:
1483:
1481:New Caledonia
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1417:Taiwan Paiwan
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1249:Zambia Lusaka
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1175:
1171:
1169:China Beijing
1167:
1163:
1159:
1155:
1151:
1147:
1143:
1139:
1137:Brazil Terena
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1079:
1075:
1073:Ireland South
1071:
1067:
1063:
1059:
1055:
1051:
1047:
1043:
1039:
1035:
1031:
1027:
1023:
1019:
1015:
1011:
1007:
1003:
999:
995:
991:
987:
983:
979:
977:Italy Bergamo
975:
971:
967:
963:
959:
955:
951:
947:
943:
939:
935:
931:
927:
923:
919:
915:
911:
907:
903:
899:
895:
891:
887:
883:
879:
875:
871:
867:
859:
856:
852:
846:
845:
841:
840:
834:
832:
826:
824:
817:
815:
812:
803:
801:
794:
792:
789:
780:
773:
770:
767:
766:
762:
759:
756:
755:
751:
748:
745:
744:
740:
737:
734:
733:
729:
726:
723:
722:
718:
715:
712:
711:
707:
704:
701:
700:
696:
693:
690:
689:
685:
683:
680:
677:
676:
670:
663:
661:
658:
654:
649:
647:
644:
640:
636:
633:
629:
621:
617:
612:
605:
602:
598:
594:
591:
588:
584:
580:
577:
574:
570:
566:
560:
555:
549:
545:
540:
533:
530:
526:
522:
519:
516:
512:
508:
505:
502:
498:
494:
491:
488:
484:
480:
475:
469:
463:
457:
451:
445:
439:
433:
427:
421:
415:
409:
403:
397:
391:
385:
379:
373:
367:
361:
355:
349:
343:
337:
331:
325:
319:
313:
307:
301:
295:
289:
283:
277:
271:
265:
259:
253:
247:
241:
235:
229:
223:
217:
211:
205:
199:
193:
187:
181:
177:
174:
170:
166:
160:
155:
149:
145:
140:
136:
132:
129:
121:
118:
116:
112:
109:
105:
103:
99:
96:
92:
89:
87:
83:
78:
56:
52:Rendering of
49:
44:
40:
36:
31:
26:
22:
4571:
4567:
4561:
4528:
4524:
4517:
4492:
4488:
4482:
4465:
4461:
4455:
4436:
4380:
4374:
4322:
4318:
4305:
4270:
4266:
4216:
4212:
4201:
4176:
4172:
4165:
4135:(4): 241–6.
4132:
4128:
4122:
4099:
4090:
4072:
4060:. Retrieved
4035:. Retrieved
3997:
3993:
3987:
3974:
3948:
3945:
3919:
3902:
3901:
3585:
3566:
3553:
3536:
3521:
3510:
3170:Taiwan Pazeh
3138:Taiwan Hakka
2869:Taiwan Hakka
2829:Taiwan Rukai
2805:USA Hispanic
2773:Taiwan Pazeh
2613:Taiwan Bunun
1979:Taiwan Hakka
1955:Taiwan Pazeh
1497:PNG Wanigela
1441:Taiwan Rukai
1369:Taiwan Pazeh
1361:Taiwan Hakka
1241:Jordan Amman
830:
827:By haplotype
821:
807:
798:
784:
681:
667:
650:
630:(A*02) is a
627:
626:
618:database at
542:Rare alleles
4062:20 December
3829:Yugoslavian
3471:Iran Baloch
3341:(in %)
3242:Taiwan Thao
3040:(in %)
2981:Iran Baloch
2789:Taiwan Thao
2459:(in %)
2088:Kenya Nandi
2070:(in %)
1833:(in %)
1588:(in %)
1449:Taiwan Tsou
1145:Iran Baloch
1089:China Tibet
863:(in %)
788:proteolysis
637:within the
134:Older names
108:heterodimer
72:HIV peptide
35:MHC Class I
4219:(1): 100.
4102:. Oxford:
3980:References
3903:A2-Cw5-B44
3619:Population
3592:A2-Cw5-B44
2965:Taiwan Ami
2581:Japan pop5
2573:Japan pop3
2168:Turkey (1)
1513:Taiwan Tao
1465:Taiwan Ami
1049:Turkey (1)
774: 228
763: 135
752: 636
741: 462
730: 472
719: 859
496:A2.3, A203
58::
19:See also:
4631:serotypes
3843:Hungarian
3194:Japan (3)
3162:USA Asian
2693:USA Asian
2224:Kenya Luo
1963:USA Asian
1265:Japan (3)
697:size (N)
471:,
465:,
459:,
453:,
447:,
441:,
435:,
429:,
423:,
417:,
411:,
405:,
399:,
393:,
387:,
381:,
375:,
369:,
363:,
357:,
351:,
345:,
339:,
333:,
327:,
321:,
315:,
309:,
303:,
297:,
291:,
285:,
279:,
273:,
267:,
261:,
255:,
249:,
243:,
237:,
231:,
225:,
219:,
213:,
207:,
201:,
195:,
189:,
183:,
102:Structure
4790:Category
4553:29932752
4509:11163085
4397:12753660
4347:24567105
4339:17630352
4297:12134033
4245:24041011
4193:11133372
4157:12367668
4149:17627758
4098:(2014).
4080:IMGT/HLA
3611:Rank in
3106:Thailand
2885:Thailand
2208:Bulgaria
2096:Sudanese
1899:Thailand
1734:Sudanese
1529:Thailand
1209:Sudanese
1065:Romanian
921:Bulgaria
664:Serotype
635:serotype
628:HLA-A*02
616:IMGT/HLA
142:Subtypes
115:Subunits
4588:8988539
4545:9098428
4474:9523161
4236:3849644
3884:Austria
3874:Romania
3857:British
3739:Ukraine
3724:Spanish
3649:Ireland
3634:Cornish
3575:A2-B40
3554:A2-B16
3537:A2-B15
3526:A2-B14
2240:Tunisia
1782:Tunisia
1201:Tunisia
1025:Croatia
1017:Belgium
897:Finland
835:Alleles
809:called
686:Sample
552:Subtype
477:
152:Subtype
122:*02--,
86:Protein
4586:
4551:
4543:
4507:
4472:
4443:
4395:
4345:
4337:
4295:
4288:155130
4285:
4243:
4233:
4191:
4155:
4147:
4110:
4012:
3971:*02:02
3969:~ DQB1
3967:*02:01
3965:~ DQA1
3963:*07:01
3961:~ DRB1
3959:*44:02
3955:*05:01
3951:*02:01
3942:*03:02
3940:~ DQB1
3938:*03:01
3936:~ DQA1
3934:*04:01
3932:~ DRB1
3930:*44:02
3926:*05:01
3922:*02:01
3799:Basque
3709:Polish
3679:Sweden
3587:A2-B46
3582:A2-B61
3579:A2-B60
3571:A2-B35
3569:A2-B27
3567:A2-B18
3563:A2-B45
3559:A2-B44
3544:A2-B63
3541:A2-B62
3533:A2-B65
3530:A2-B64
3524:A2-B13
3518:A2-B52
3515:A2-B51
3339:
3038:
2457:
2068:
1831:
1586:
1161:Brazil
861:
768:*02:11
757:*02:07
746:*02:06
735:*02:05
724:*02:03
713:*02:02
702:*02:01
691:allele
601:*02:11
587:*02:07
573:*02:04
557:allele
529:*02:06
515:*02:05
501:*02:03
487:*02:02
173:*02:01
157:allele
95:ligand
70:, and
28:HLA-A2
4642:HLA-A
4628:HLA-A
4549:S2CID
4343:S2CID
4319:Blood
4315:(PDF)
4153:S2CID
4037:8 Dec
4014:77067
3814:Greek
3784:Czech
3694:Swiss
3627:Pop.
3522:A2-B8
3336:Freq.
3035:Freq.
2454:Freq.
2336:Kenya
2065:Freq.
1828:Freq.
1654:Kenya
1583:Freq.
1305:Kenya
858:Freq.
708:6315
678:A*02
657:HLA-A
646:locus
639:HLA-A
582:A2.4b
524:A2.4a
510:A2.2Y
482:A2.2F
137:HL-A2
120:HLA-A
80:About
4584:PMID
4541:PMID
4505:PMID
4470:PMID
4441:ISBN
4393:PMID
4335:PMID
4293:PMID
4241:PMID
4189:PMID
4145:PMID
4108:ISBN
4064:2013
4039:2013
4010:PMID
3877:2.5
3769:Dane
3637:11.4
3616:ref.
3606:freq
3362:13.0
3354:16.0
3109:10.9
3101:11.3
3093:11.6
3085:12.2
3077:13.1
3069:13.1
3061:13.4
3053:15.7
2560:10.5
2552:12.0
2544:12.5
2536:13.0
2528:14.3
2520:16.5
2512:18.3
2504:20.0
2496:21.6
2488:21.6
2480:26.1
2472:34.9
2304:Oman
1870:10.8
1862:12.2
1854:15.2
1846:17.6
1601:10.4
1284:10.2
1276:10.7
1268:11.6
1260:12.1
1252:12.8
1244:13.4
1236:13.8
1228:14.3
1220:16.5
1212:17.3
1204:17.5
1196:17.5
1188:17.8
1180:18.4
1172:18.7
1164:19.2
1156:20.0
1148:20.2
1140:20.8
1132:21.3
1124:21.6
1116:21.6
1113:Oman
1108:21.7
1100:21.7
1092:21.8
1084:22.3
1076:24.6
1068:25.0
1060:25.0
1052:25.7
1044:26.0
1036:26.1
1028:26.3
1020:26.6
1012:27.0
1004:27.2
996:27.4
988:27.4
980:28.0
972:28.4
964:28.9
956:29.3
948:29.7
940:29.9
932:30.0
924:30.0
916:31.0
908:34.1
900:34.4
892:37.8
884:43.6
876:54.5
596:A2.5
568:A2.4
474:1hla
468:1hhk
462:1hhj
456:1hhi
450:1hhh
444:1hhg
438:1eez
432:1eey
426:1duz
420:1duy
414:1bd2
408:1b0r
402:1b0g
396:1ao7
390:1akj
384:1im3
378:1i7u
372:1i7t
366:1i7r
360:1i4f
354:1i1y
348:1i1f
342:1jht
336:1jf1
330:1p7q
324:1qrn
318:1qr1
312:1qse
306:1t22
300:1t21
294:1t20
288:1t1z
282:1t1y
276:1t1x
270:1t1w
264:1s9y
258:1s9x
252:1s9w
246:1s8d
240:1tvh
234:1tvb
228:2av7
222:2av1
216:2bsu
210:2c7u
204:2bsv
198:2clr
192:2git
186:2gj6
180:3hla
168:A2.1
55:2git
4775:A80
4770:A36
4763:A69
4758:A68
4753:A28
4746:A74
4741:A33
4736:A32
4731:A31
4726:A30
4721:A29
4716:A19
4711:A11
4704:A66
4699:A43
4694:A34
4689:A26
4684:A25
4679:A10
4672:A24
4667:A23
4576:doi
4533:doi
4497:doi
4385:doi
4327:doi
4323:110
4283:PMC
4275:doi
4231:PMC
4221:doi
4181:doi
4177:183
4137:doi
4002:doi
3957:~ B
3953:~ C
3928:~ B
3924:~ C
3911:DQ8
3907:DR4
3887:2.4
3860:2.6
3846:3.5
3832:4.4
3817:4.5
3802:4.7
3787:4.7
3772:4.8
3757:5.9
3742:5.9
3727:5.9
3712:6.2
3697:6.9
3682:7.2
3667:8.0
3652:9.2
3622:(%)
3482:1.1
3474:1.1
3466:1.2
3458:1.6
3450:1.7
3442:2.0
3434:2.0
3426:2.3
3418:2.5
3410:4.0
3402:4.8
3394:6.7
3386:7.4
3378:8.6
3370:9.7
3293:1.0
3285:1.0
3277:1.0
3269:1.4
3261:1.6
3253:1.6
3245:1.7
3237:2.0
3229:2.1
3221:2.2
3213:2.5
3205:3.0
3197:3.4
3189:3.6
3181:4.3
3173:6.4
3165:6.6
3157:6.7
3149:6.9
3141:8.2
3133:8.2
3125:9.3
3117:9.4
2992:1.1
2984:1.1
2976:1.2
2968:1.5
2960:1.6
2952:2.0
2944:2.0
2936:2.0
2928:2.0
2920:2.0
2912:2.1
2904:2.3
2896:2.4
2888:2.5
2880:2.6
2872:2.7
2864:2.8
2856:2.9
2848:2.9
2840:2.9
2832:3.0
2824:3.0
2816:3.1
2808:3.2
2800:3.2
2792:3.3
2784:3.5
2776:3.6
2768:4.0
2760:4.0
2752:4.0
2744:4.3
2736:4.6
2728:4.7
2720:4.7
2712:4.8
2704:4.9
2696:5.0
2688:5.2
2680:5.5
2672:6.0
2664:6.1
2656:6.9
2648:7.1
2640:7.1
2632:7.2
2624:7.3
2616:7.4
2608:7.6
2600:7.7
2592:7.7
2584:8.4
2576:8.7
2568:9.4
2411:1.0
2403:1.0
2395:1.0
2387:1.0
2379:1.1
2371:1.1
2363:1.1
2355:1.1
2347:1.2
2339:1.4
2331:1.4
2323:1.4
2315:1.7
2307:2.1
2299:2.1
2291:2.2
2283:2.2
2275:2.2
2267:2.3
2259:2.4
2251:2.4
2243:2.5
2235:2.5
2227:2.6
2219:2.6
2211:2.7
2203:3.0
2195:3.0
2187:3.1
2179:3.2
2171:3.5
2163:3.8
2155:4.0
2147:4.3
2139:5.0
2131:5.0
2123:5.5
2115:5.8
2107:6.1
2099:6.5
2091:8.7
2083:9.2
2022:1.0
2014:1.1
2006:2.3
1998:2.4
1990:2.4
1982:3.6
1974:3.7
1966:4.2
1958:4.5
1950:5.0
1942:5.0
1934:5.2
1926:5.9
1918:6.0
1910:6.4
1902:7.7
1894:8.2
1886:9.0
1878:9.8
1785:1.0
1777:1.0
1769:1.1
1761:1.4
1753:1.7
1745:1.7
1737:1.8
1729:2.0
1721:2.3
1713:2.3
1705:2.4
1697:3.4
1689:3.5
1681:3.6
1673:3.7
1665:3.8
1657:4.9
1649:5.3
1641:6.0
1633:6.2
1625:7.6
1617:8.2
1609:9.1
1540:1.0
1532:1.8
1524:1.9
1516:2.0
1508:2.0
1500:2.1
1492:2.4
1484:2.4
1476:2.5
1468:2.6
1460:2.8
1452:2.9
1444:3.0
1436:3.1
1428:3.4
1420:3.9
1412:4.0
1404:4.6
1396:4.9
1388:5.1
1380:5.3
1372:5.5
1364:5.5
1356:5.8
1348:6.5
1340:7.1
1332:8.1
1324:8.3
1316:8.3
1308:8.7
1300:9.0
1292:9.1
811:Nef
643:B2M
620:EBI
106:αβ
4792::
4662:A9
4657:A3
4652:A2
4647:A1
4582:.
4572:48
4570:.
4547:.
4539:.
4529:21
4527:.
4503:.
4493:61
4491:.
4466:14
4464:.
4405:^
4391:.
4381:61
4379:.
4355:^
4341:.
4333:.
4321:.
4317:.
4291:.
4281:.
4271:76
4269:.
4265:.
4253:^
4239:.
4229:.
4217:10
4215:.
4211:.
4187:.
4175:.
4151:.
4143:.
4133:34
4131:.
4106:.
4082:-
4047:^
4022:^
4008:.
3998:11
3996:.
3917::
3865:4
3822:3
3807:3
3792:3
3777:1
3762:3
3747:1
3732:1
3717:1
3702:2
3687:2
3672:2
3657:2
3642:1
771:74
760:80
749:68
738:81
727:64
716:81
705:98
694:%
682:A2
62:,
37:,
4620:e
4613:t
4606:v
4590:.
4578::
4555:.
4535::
4511:.
4499::
4476:.
4449:.
4399:.
4387::
4349:.
4329::
4299:.
4277::
4247:.
4223::
4195:.
4183::
4159:.
4139::
4116:.
4066:.
4041:.
4016:.
4004::
3949:A
3920:A
3909:~
126:2
124:β
93:/
74:.
66:2
64:β
39:A
33:(
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