42:
835:
A*2501 distribution is primarily located in
Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.
852:
Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin".
274:
227:
serotype group. The serotype is determined by the antibody recognition of α subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A
994:
887:
Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology".
279:
A25 is more common in SW Asia to NW Europe. A25 is believed to have been formed by a single gene conversion between another HLA-A and the
928:
205:
940:
Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net".
987:
942:
980:
217:
186:
172:
158:
1171:
62:
924:
201:
232:
95:
73:
144:
959:
904:
869:
951:
896:
861:
825:
86:
900:
865:
247:
243:
1165:
955:
41:
79:
28:
921:
364:
963:
908:
1006:
220:
873:
290:
1150:
1145:
1138:
1133:
1128:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1079:
1074:
1069:
1064:
1054:
1047:
1042:
280:
267:
263:
259:
255:
251:
57:
235:
1037:
1032:
1027:
1022:
66:
347:
A25 reasonably good serotyping with no overt false recognition..
1017:
1003:
972:
224:
91:
32:
976:
238:. This group currently is dominated by A*2501. A25 and A
811:
803:
795:
787:
779:
771:
763:
755:
747:
739:
731:
723:
715:
707:
699:
691:
683:
675:
667:
659:
651:
643:
635:
627:
619:
611:
603:
595:
587:
579:
571:
563:
555:
547:
539:
531:
523:
515:
507:
499:
491:
483:
475:
467:
459:
451:
443:
435:
427:
419:
411:
403:
395:
387:
379:
375:
360:
181:
167:
153:
139:
122:
113:
105:
85:
72:
56:
51:
21:
292:A25 recognition of some HLA A*25 gene products
275:History and naming of human leukocyte antigens
988:
8:
355:
231:allele group and the β-chain are encoded by
242:are almost synonymous in meaning. A25 is a
995:
981:
973:
119:
40:
844:
354:
18:
7:
901:10.1111/j.1399-0039.1993.tb01982.x
866:10.1111/j.1399-0039.1978.tb01233.x
14:
929:European Bioinformatics Institute
956:10.1034/j.1399-0039.2003.00062.x
16:Human leukocyte antigen serotype
254:. A25 is a sister serotype of
1:
1188:
780:USA South Dakota Lakota S…
772:Morocco 'Berber' Nador Me…
748:Russia Sakhalin Island Ni…
652:Spain Basque Gipuzkoa Pro…
492:Spain Basque Arratia Vall…
272:
1013:
823:
819:
764:USA South Texas Hispanics
564:Australia New South Wales
436:Russia Arkhangelsk Pomors
199:
134:Available structures
118:
39:
26:
556:Spain Eastern Andalusia
218:human leukocyte antigen
708:Spain Catalonia Girona
612:Azores Central Islands
532:Argentina Buenos Aires
444:Spain North Cabuernigo
428:Spain North Cantabrian
356:HLA A*2501 frequencies
63:transmembrane receptor
740:Russia Murmansk Saomi
572:Georgia Svaneti Svans
500:Sweden Uppsala County
388:India Jalpaiguri Toto
273:Further information:
35:cell surface antigen)
660:Italy South Campania
200:Alleles link-out to
700:Portugal Centre (2)
357:
293:
826:Allele frequencies
468:USA Caucasians (3)
291:
1159:
1158:
922:Allele Query Form
833:
832:
829:
812:China Qinghai Hui
756:France South East
636:England Sheffield
628:England Lancaster
604:England Liverpool
371:
345:
344:
211:
210:
195:
194:
187:*25{{{cAllele4}}}
173:*25{{{cAllele3}}}
159:*25{{{cAllele2}}}
1179:
997:
990:
983:
974:
968:
967:
937:
931:
919:
913:
912:
884:
878:
877:
849:
824:
796:USA Arizona Pima
596:Sweden Stockholm
540:Ireland Northern
412:Spain Pas Valley
396:Russia Northwest
369:
361:Study population
358:
338:
308:
294:
266:, and
241:
230:
189:
175:
161:
147:
120:
44:
19:
1187:
1186:
1182:
1181:
1180:
1178:
1177:
1176:
1162:
1161:
1160:
1155:
1009:
1001:
971:
943:Tissue Antigens
939:
938:
934:
920:
916:
889:Tissue Antigens
886:
885:
881:
854:Tissue Antigens
851:
850:
846:
842:
828:presented, only
508:Scotland Orkney
367:
353:
351:A25 frequencies
336:
306:
289:
277:
239:
228:
185:
171:
157:
143:
135:
130:
125:
99:
47:
17:
12:
11:
5:
1185:
1183:
1175:
1174:
1164:
1163:
1157:
1156:
1154:
1153:
1148:
1143:
1142:
1141:
1136:
1126:
1125:
1124:
1119:
1114:
1109:
1104:
1099:
1089:
1084:
1083:
1082:
1077:
1072:
1067:
1062:
1052:
1051:
1050:
1045:
1035:
1030:
1025:
1020:
1014:
1011:
1010:
1002:
1000:
999:
992:
985:
977:
970:
969:
950:(5): 403–407.
932:
914:
879:
843:
841:
838:
831:
830:
821:
820:
817:
816:
813:
809:
808:
805:
801:
800:
797:
793:
792:
789:
785:
784:
781:
777:
776:
773:
769:
768:
765:
761:
760:
757:
753:
752:
749:
745:
744:
741:
737:
736:
733:
729:
728:
725:
724:France Corsica
721:
720:
717:
713:
712:
709:
705:
704:
701:
697:
696:
693:
689:
688:
685:
684:Australia West
681:
680:
677:
676:Uganda Kampala
673:
672:
669:
665:
664:
661:
657:
656:
653:
649:
648:
645:
641:
640:
637:
633:
632:
629:
625:
624:
621:
617:
616:
613:
609:
608:
605:
601:
600:
597:
593:
592:
589:
585:
584:
581:
577:
576:
573:
569:
568:
565:
561:
560:
557:
553:
552:
549:
545:
544:
541:
537:
536:
533:
529:
528:
525:
521:
520:
517:
513:
512:
509:
505:
504:
501:
497:
496:
493:
489:
488:
485:
481:
480:
477:
473:
472:
469:
465:
464:
461:
457:
456:
453:
449:
448:
445:
441:
440:
437:
433:
432:
429:
425:
424:
421:
420:Czech Republic
417:
416:
413:
409:
408:
405:
401:
400:
397:
393:
392:
389:
385:
384:
381:
377:
376:
373:
372:
362:
352:
349:
343:
342:
339:
334:
331:
327:
326:
323:
320:
317:
313:
312:
309:
303:
298:
288:
285:
209:
208:
197:
196:
193:
192:
190:
183:
179:
178:
176:
169:
165:
164:
162:
155:
151:
150:
148:
141:
137:
136:
133:
131:
128:
126:
123:
116:
115:
111:
110:
107:
103:
102:
100:-microglobulin
97:
89:
83:
82:
76:
70:
69:
60:
54:
53:
49:
48:
45:
37:
36:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1184:
1173:
1172:HLA-A alleles
1170:
1169:
1167:
1152:
1149:
1147:
1144:
1140:
1137:
1135:
1132:
1131:
1130:
1127:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1094:
1093:
1090:
1088:
1085:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1057:
1056:
1053:
1049:
1046:
1044:
1041:
1040:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1015:
1012:
1008:
1005:
998:
993:
991:
986:
984:
979:
978:
975:
965:
961:
957:
953:
949:
945:
944:
936:
933:
930:
926:
923:
918:
915:
910:
906:
902:
898:
894:
890:
883:
880:
875:
871:
867:
863:
860:(2): 96–112.
859:
855:
848:
845:
839:
837:
827:
822:
818:
814:
810:
806:
802:
798:
794:
790:
786:
782:
778:
774:
770:
766:
762:
758:
754:
750:
746:
742:
738:
734:
732:Mongolia Oold
730:
726:
722:
718:
714:
710:
706:
702:
698:
694:
690:
686:
682:
678:
674:
670:
668:New Caledonia
666:
662:
658:
654:
650:
646:
642:
638:
634:
630:
626:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
452:Ireland South
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
366:
363:
359:
350:
348:
340:
335:
332:
329:
328:
324:
321:
318:
315:
314:
310:
304:
302:
299:
296:
295:
286:
284:
282:
276:
271:
269:
265:
261:
257:
253:
249:
248:broad antigen
245:
244:split antigen
237:
234:
226:
222:
219:
215:
207:
203:
198:
191:
188:
184:
180:
177:
174:
170:
166:
163:
160:
156:
152:
149:
146:
142:
138:
132:
127:
121:
117:
112:
108:
104:
101:
93:
90:
88:
84:
81:
77:
75:
71:
68:
64:
61:
59:
55:
50:
43:
38:
34:
30:
25:
20:
1059:
947:
941:
935:
917:
895:(2): 72–80.
892:
888:
882:
857:
853:
847:
834:
644:Israeli Jews
516:German Essen
380:Saudi Arabia
346:
300:
278:
213:
212:
204:database at
182:{{{cNick4}}}
168:{{{cNick3}}}
154:{{{cNick2}}}
370:(in %)
216:(A25) is a
106:Older names
80:heterodimer
29:MHC Class I
840:References
1007:serotypes
588:Macedonia
325:size (N)
283:allele..
250:serotype
74:Structure
1166:Category
964:12753660
925:IMGT/HLA
804:Algeria1
484:Bulgaria
460:Romanian
287:Serotype
221:serotype
202:IMGT/HLA
114:Subtypes
87:Subunits
909:8475492
716:Belgium
692:Finland
548:Morocco
476:Croatia
311:Sample
262:,
258:,
246:of the
223:within
214:HLA-A25
124:Subtype
94:*2501,
58:Protein
46:HLA-A25
22:HLA-A25
962:
907:
872:
788:Greece
620:Turkey
404:Serbia
368:
316:allele
281:A*2601
129:allele
67:ligand
1018:HLA-A
1004:HLA-A
874:77067
580:Italy
524:Wales
365:Freq.
341:1375
330:*2501
297:A*25
236:locus
225:HLA-A
145:*2501
92:HLA-A
52:About
960:PMID
905:PMID
870:PMID
1151:A80
1146:A36
1139:A69
1134:A68
1129:A28
1122:A74
1117:A33
1112:A32
1107:A31
1102:A30
1097:A29
1092:A19
1087:A11
1080:A66
1075:A43
1070:A34
1065:A26
1060:A25
1055:A10
1048:A24
1043:A23
952:doi
897:doi
862:doi
815:0.5
807:0.5
799:0.6
791:0.6
783:0.7
775:0.7
767:0.8
759:0.8
751:0.9
743:1.0
735:1.0
727:1.0
719:1.0
711:1.1
703:1.1
695:1.1
687:1.1
679:1.2
671:1.2
663:1.2
655:1.5
647:1.5
639:1.6
631:1.8
623:1.8
615:1.8
607:1.9
599:1.9
591:1.9
583:1.9
575:1.9
567:1.9
559:2.0
551:2.0
543:2.0
535:2.0
527:2.1
519:2.4
511:2.5
503:2.5
495:2.7
487:2.7
479:3.0
471:3.4
463:3.5
455:3.6
447:3.8
439:4.0
431:4.2
423:4.2
415:4.3
407:4.8
399:5.1
391:5.1
383:5.7
301:A25
268:A66
264:A43
260:A34
256:A26
252:A10
240:*25
233:B2M
229:*25
206:EBI
140:A25
109:A10
78:αβ
1168::
1038:A9
1033:A3
1028:A2
1023:A1
958:.
948:61
946:.
927:-
903:.
893:41
891:.
868:.
858:11
856:.
333:95
322:%
307:10
270:.
31:,
996:e
989:t
982:v
966:.
954::
911:.
899::
876:.
864::
337:2
319:%
305:A
98:2
96:β
65:/
33:A
27:(
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