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HLA-B

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2207:: A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. It is uncertain how HLA-B27 causes this increased risk. Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis. Other research suggests that joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder. Other genetic and environmental factors are likely to affect the chances of developing ankylosing spondylitis and influence its progression. 2287:). AIDS is a disease that damages the immune system, preventing it from effectively defending the body against infections. The signs and symptoms of AIDS may not appear until 10 years or more after infection with HIV. Studies suggest that people with HIV infection who have HLA-B27 or HLA-B57 tend to progress more slowly than usual to AIDS. On the other hand, researchers believe that HIV-positive individuals who have HLA-B35 tend to develop the signs and symptoms of AIDS more quickly than usual. Other factors also influence the progression of HIV to AIDS. 1664: 3804: 3429: 3534: 3519: 748: 773: 3564: 3369: 3549: 3279: 3414: 3264: 3324: 3354: 3339: 3309: 3294: 3789: 3774: 3759: 3639: 3624: 3699: 3744: 3729: 3384: 3399: 3249: 3849: 3594: 3579: 3879: 3609: 3684: 3669: 3654: 3504: 3864: 3834: 3819: 3714: 3489: 779: 3444: 3474: 3459: 2230:, is typically triggered by bacterial infections of the gastrointestinal or genital tract. Following an infection, affected individuals may develop arthritis, back pain, and eye inflammation. Like ankylosing spondylitis, many factors probably contribute to the development of reactive arthritis and other spondyloarthropathies. 3163:
Tassaneeyakul W, Tiamkao S, Jantararoungtong T, Chen P, Lin SY, Chen WH, Konyoung P, Khunarkornsiri U, Auvichayapat N, Pavakul K, Kulkantrakorn K, Choonhakarn C, Phonhiamhan S, Piyatrakul N, Aungaree T, Pongpakdee S, Yodnopaglaw P (May 2010). "Association between HLA-B*1502 and carbamazepine-induced
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Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W (September 2009). "Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic
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HLA-B is one of three major HLAs that should be matched between donors and recipients. They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC). If the two tissues have the same genes coding for these three HLAs, the likelihood and severity of rejection is minimized.
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Hetherington S, Hughes AR, Mosteller M, Shortino D, Baker KL, Spreen W, Lai E, Davies K, Handley A, Dow DJ, Fling ME, Stocum M, Bowman C, Thurmond LM, Roses AD (March 2002). "Genetic variations in HLA-B region and hypersensitivity reactions to abacavir".
1631:) that have been exported from within the cell. MHC class I proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by destroying the infected cell. 1634:
The HLA-B gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign invaders. Hundreds of versions (alleles) of HLA-B are known, each of which is given a particular number (such as
696:, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1 3803: 2280:. This drug is a treatment for HIV-1 that slows the spread of the virus in the body. People with abacavir hypersensitivity often develop a fever, chills, rash, upset stomach, and other symptoms when treated with this drug. 3428: 3533: 3518: 29: 2337:
ENSG00000234745, ENSG00000206450, ENSG00000224608, ENSG00000223532, ENSG00000232126 GRCh38: Ensembl release 89: ENSG00000228964, ENSG00000234745, ENSG00000206450, ENSG00000224608, ENSG00000223532, ENSG00000232126
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Other disorders: Several variations of the HLA-B gene are associated with adverse reactions to certain drugs. For example, two specific versions of this gene are related to increased drug sensitivity among the
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is a frequent cause of death in children. Researchers suggest that this version of the HLA-B gene may help the immune system respond more effectively to the parasite that causes malaria.
3398: 3248: 3848: 3593: 3578: 1639:). Closely related alleles are categorized together; for example, at least 28 very similar alleles are subtypes of HLA-B27. These subtypes are designated as HLA-B*2701 to HLA-B*2728. 3878: 1627:
MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (
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Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT (March 2005).
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Another version of the HLA-B gene, HLA-B53, has been shown to help protect against severe malaria. HLA-B53 is most common in West African populations, where
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Migueles SA, Sabbaghian MS, Shupert WL, Bettinotti MP, Marincola FM, Martino L, Hallahan CW, Selig SM, Schwartz D, Sullivan J, Connors M (March 2000).
1275: 2257:(a drug used to treat seizures). Another version, HLA-B*5801, is associated with an increased risk of severe skin reactions in people treated with 3488: 2527:
Brown MA, Crane AM, Wordsworth BP (July 2002). "Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis".
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Gao X, Nelson GW, Karacki P, Martin MP, Phair J, Kaslow R, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, O'Brien SJ, Carrington M (May 2001).
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Several other variations of the HLA-B gene appear to play a role in the progression of HIV infection to acquired immunodeficiency syndrome (
4235: 1685: 1589:(HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as 3812:: INSIGHTS INTO CROSSREACTIVITY IN HUMAN ALLORECOGNITION: THE STRUCTURE OF HLA-B35011 PRESENTING AN EPITOPE DERIVED FROM CYTOCHROME P450. 2886: 2718: 3912: 2443: 3437:: THE THREE-DIMENSIONAL STRUCTURE OF HLA-B27 AT 2.1 ANGSTROMS RESOLUTION SUGGESTS A GENERAL MECHANISM FOR TIGHT PEPTIDE BINDING TO MHC 1506: 3542:: CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE VASOACTIVE INTESTINAL PEPTIDE TYPE 1 RECEPTOR (VIPR) PEPTIDE (RESIDUES 400-408) 3527:: CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE VASOACTIVE INTESTINAL PEPTIDE TYPE 1 RECEPTOR (VIPR) PEPTIDE (RESIDUES 400-408) 2385:
Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael AJ, Greenwood BM (August 1991).
1707: 3936: 4184: 3993: 1601: 4245: 2340: 3443: 3019:"HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors" 3473: 3458: 3071: 2214:, a group of related inflammatory joint diseases. Some of these diseases are associated with a common skin condition called 772: 747: 2336: 2250: 2273: 1678: 1672: 785: 4214: 3977: 3572:: CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE LATENT MEMBRANE PROTEIN 2 PEPTIDE (LMP2) OF EPSTEIN-BARR VIRUS 3377:: COMPLEX RECOGNITION OF THE SUPERTYPIC BW6-DETERMINANT ON HLA-B AND-C MOLECULES BY THE MONOCLONAL ANTIBODY SFR8-B6 3557:: CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE LATENT MEMBRANE PROTEIN 2 PEPTIDE (LMP2)OF EPSTEIN-BARR VIRUS 778: 4204: 3287:: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS 3272:: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS 3221: 3422:: STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3 1689: 1604:(MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: 3332:: ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYKL-INDEX PEPTIDE) 52: 4179: 3362:: ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKRYKL-5R MUTATION) 3347:: ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYRL-7R MUTATION) 3317:: ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYQL-7Q MUTATION) 3302:: ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGRKKYKL-3R MUTATION) 1586: 1340: 1330: 1326: 1322: 1318: 1314: 4240: 4209: 3797:: CRYSTAL STRUCTURES AND KIR3DL1 RECOGNITION OF THREE IMMUNODOMINANT VIRAL PEPTIDES COMPLEXED TO HLA-B2705 3782:: CRYSTAL STRUCTURES AND KIR3DL1 RECOGNITION OF THREE IMMUNODOMINANT VIRAL PEPTIDES COMPLEXED TO HLA-B2705 3767:: CRYSTAL STRUCTURES AND KIR3DL1 RECOGNITION OF THREE IMMUNODOMINANT VIRAL PEPTIDES COMPLEXED TO HLA-B2705 3647:: Crystal Structures of HLA-B*1501 in Complex with Peptides from Human UbcH6 and Epstein-Barr Virus EBNA-3 3632:: Crystal Structures of HLA-B*1501 in Complex with Peptides from Human UbcH6 and Epstein-Barr Virus EBNA-3 3199: 2931: 2204: 2238: 3970: 2249:
population. Individuals who have HLA-B*1502 are more likely to experience a severe skin disorder called
2211: 2276:(HIV) infection, a version of HLA-B designated HLA-B*5701 is associated with an extreme sensitivity to 3707:: Crystal structure of hla-b*2705 complexed with the glucagon receptor (gr) peptide (residues 412-420) 3214: 3030: 2848: 2610: 2398: 1643: 761: 3752:: The Immunogenicity of a Viral Cytotoxic T Cell Epitope is controlled by its MHC-bound Conformation 3737:: The Immunogenicity of a Viral Cytotoxic T Cell Epitope is controlled by its MHC-bound Conformation 3392:: NONSTANDARD PEPTIDE BINDING OF HLA-B*5101 COMPLEXED WITH HIV IMMUNODOMINANT EPITOPE KM1(LPPVVAKEI) 2936: 2837:"HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol" 692: 3407:: NONSTANDARD PEPTIDE BINDING OF HLA-B*5101 COMPLEXED WITH HIV IMMUNODOMINANT EPITOPE KM2(TAFTIPSI) 3257:: MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1 2764:"Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS" 3857:: Crystal structure of HLA-B*3501 presenting the human cytochrome P450 derived peptide, KPIVVLHGY 3189: 3151: 3005: 2957: 2823: 2750: 2636: 2552: 2424: 2227: 2223: 1170:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
721: 3602:: CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE SELF-PEPTIDE TIS FROM EGF-RESPONSE FACTOR 1 3587:: CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE SELF-PEPTIDE TIS FROM EGF-RESPONSE FACTOR 1 2219: 1470: 1425: 1140:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
4189: 3942: 3887:: Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A 3181: 3143: 3113: 3058: 2997: 2949: 2910: 2876: 2815: 2785: 2742: 2708: 2665: 2628: 2585: 2544: 2504: 2416: 685: 45: 2945: 2725:
Cooke GS, Hill AV (December 2001). "Genetics of susceptibility to human infectious disease".
2451: 3173: 3135: 3103: 3095: 3048: 3038: 2987: 2941: 2902: 2866: 2856: 2807: 2775: 2734: 2698: 2690: 2657: 2618: 2577: 2536: 2494: 2486: 2406: 865: 796: 3962: 3929: 3617:: Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501 717: 4151: 3075: 980: 840: 2581: 3034: 2852: 2614: 2402: 3108: 3083: 2499: 2474: 2871: 2836: 2811: 2703: 2678: 1209: 1204: 1199: 1194: 1189: 1184: 1179: 1174: 1169: 1164: 1159: 1154: 1149: 1144: 1139: 1134: 1118: 1113: 1108: 1103: 1098: 1093: 1088: 1083: 1078: 1073: 1068: 1063: 1058: 1053: 1048: 1043: 1027: 1022: 4229: 3951: 3177: 3053: 3018: 2763: 2540: 2387:"Common west African HLA antigens are associated with protection from severe malaria" 2254: 1613: 1582: 1009: 3193: 3155: 3009: 2961: 2754: 2556: 4045: 2827: 2648:
Colbert RA (February 2004). "The immunobiology of HLA-B27: variations on a theme".
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Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT (April 2004).
3139: 3068: 2679:"HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations" 725: 4199: 4002: 2893:
Khan MA, Ball EJ (September 2002). "Genetic aspects of ankylosing spondylitis".
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
3692:: Crystal Structure Of HLA-B*3501 Presenting an 11-Mer EBV Antigen EPLPQGQLTAY 2490: 755: 705: 3677:: Crystal structure of HLA-B*3508 presenting 13-mer EBV antigen LPEPLPQGQLTAY 3662:: Crystal structure of HLA-B*3501 presenting 13-mer EBV antigen LPEPLPQGQLTAY 3512:: The crystal structure of LC13 TcR in complex with HLAB8-EBV peptide complex 2661: 3872:: Crystal structure of HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A 3842:: The role of T cell receptor alpha genes in directing human MHC restriction 3827:: The role of T cell receptor alpha genes in directing human MHC restriction 2861: 2266: 2215: 1647: 1239: 958: 879: 824: 811: 713: 3185: 3147: 3117: 3062: 3043: 3001: 2953: 2914: 2906: 2880: 2819: 2789: 2746: 2712: 2669: 2632: 2589: 2548: 2508: 2450:. University of Michigan Medical Center/Stanford University. Archived from 2420: 1549: 4194: 4161: 4156: 4146: 4129: 4124: 4119: 4114: 4109: 4097: 4092: 2277: 2181: 2164: 1594: 1538: 1383: 3722:: Crystal Structure of SB27 TCR in complex with HLA-B*3508-13mer peptide 2210:
In addition to Ankylosing spondylitis, HLA-B27 is associated with other
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antigen processing and presentation of peptide antigen via MHC class I
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integral component of lumenal side of endoplasmic reticulum membrane
4035: 4030: 4025: 4020: 4010: 1621: 1617: 1590: 1571: 1224: 1220: 3916: 2312: 2284: 2262: 1574: 28: 3966: 3955:(HLA class I histocompatibility antigen, B alpha chain) at the 3210: 3164:
severe cutaneous adverse drug reactions in a Thai population".
2976:"Immunopathogenesis and immunotherapy in AIDS virus infections" 989: 3206: 1657: 3941:
Overview of all the structural information available in the
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A large number of studies have shown an association between
3497:: HLA B8 in complex with an Epstein Barr Virus determinant 3900: 2599:"Medical genetics: a marker for Stevens-Johnson syndrome" 1175:
protection from natural killer cell mediated cytotoxicity
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Khan MA (June 2002). "Update on spondyloarthropathies".
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Colmegna I, Cuchacovich R, Espinoza LR (April 2004).
1719: 970: 2475:"Banking on iPSC--is it doable and is it worthwhile" 4172: 4044: 4001: 2895:
Best Practice & Research. Clinical Rheumatology
1616:. In humans, the HLA-B gene and two related genes, 1484: 1463: 1439: 1418: 3899:This article incorporates public domain text from 2332: 2330: 2328: 1642:The HLA-B gene is located on the short (p) arm of 2448:Kidney Transplantation: Past, Present, and Future 795: 1585:. HLA-B is part of a family of genes called the 16:Protein-coding gene in the species Homo sapiens 2473:Solomon S, Pitossi F, Rao MS (February 2015). 3978: 3222: 8: 3126:epidermal necrolysis in a Thai population". 1568:major histocompatibility complex, class I, B 1165:regulation of dendritic cell differentiation 2198:"HLA-" prefix trimmed from serotype names. 1150:interferon-gamma-mediated signaling pathway 3985: 3971: 3963: 3937:Nomenclature for factors of the HLA system 3229: 3215: 3207: 1309: 1235: 1005: 836: 733: 63: 3107: 3052: 3042: 2991: 2935: 2870: 2860: 2779: 2702: 2622: 2498: 2410: 2265:, which is a form of arthritis caused by 2218:or chronic inflammatory bowel disorders ( 1708:Learn how and when to remove this message 3088:Journal of the Royal Society of Medicine 2946:10.7326/0003-4819-136-12-200206180-00011 2197: 1740: 1671:This article includes a list of general 1577:that provides instructions for making a 3452:: HLA-B*2709 bound to deca-peptide s10R 3244: 2566:"The influence of HLA genotype on AIDS" 2324: 1145:regulation of interleukin-12 production 1624:, are the major genes in MHC class I. 1205:regulation of interleukin-6 production 1099:ER to Golgi transport vesicle membrane 18: 3901:The U.S. National Library of Medicine 3482:: HLA-B*2709 BOUND TO NONA-PEPTIDE M9 3467:: HLA-B*2705 bound to nona-peptide m9 2226:). One of the spondyloarthropathies, 1079:integral component of plasma membrane 800: 759: 754: 7: 2582:10.1146/annurev.med.54.101601.152346 3913:Online Mendelian Inheritance in Man 2768:The New England Journal of Medicine 2444:"HLA Matching, Antibodies, and You" 1180:type I interferon signaling pathway 1135:antigen processing and presentation 2974:Letvin NL, Walker BD (July 2003). 1677:it lacks sufficient corresponding 1581:that plays a critical role in the 1481: 1460: 1436: 1415: 1393: 1374: 1350: 1285: 1266: 975: 936: 874: 853: 14: 2564:Carrington M, O'Brien SJ (2003). 1721:Serotypes of HLA-B gene products 4185:Minor histocompatibility antigen 3994:Major histocompatibility complex 3877: 3862: 3847: 3832: 3817: 3802: 3787: 3772: 3757: 3742: 3727: 3712: 3697: 3682: 3667: 3652: 3637: 3622: 3607: 3592: 3577: 3562: 3547: 3532: 3517: 3502: 3487: 3472: 3457: 3442: 3427: 3412: 3397: 3382: 3367: 3352: 3337: 3322: 3307: 3292: 3277: 3262: 3247: 3178:10.1111/j.1528-1167.2010.02533.x 2541:10.1097/00002281-200207000-00004 1662: 1602:major histocompatibility complex 1600:HLA is the human version of the 979: 784: 777: 771: 746: 27: 2529:Current Opinion in Rheumatology 2185: 2168: 2151: 2134: 2117: 2100: 2083: 2066: 2049: 2032: 2004: 1973: 1945: 1917: 1889: 1865: 1834: 1806: 1778: 1750: 1728: 3084:"The ramifications of HLA-B27" 1044:integral component of membrane 990:More reference expression data 959:More reference expression data 1: 3128:Pharmacogenetics and Genomics 2812:10.1016/S0140-6736(02)08158-8 2695:10.1128/CMR.17.2.348-369.2004 2683:Clinical Microbiology Reviews 2298:HLA-B and graft compatibility 1190:regulation of immune response 769: 3140:10.1097/FPC.0b013e328330a3b8 2274:human immunodeficiency virus 2179: 2162: 2145: 2128: 2111: 2094: 2077: 2060: 2043: 2026: 1998: 1967: 1939: 1911: 1883: 1859: 1828: 1800: 1772: 1744: 1724: 4236:Genes on human chromosome 6 3082:Sheehan NJ (January 2004). 2924:Annals of Internal Medicine 2781:10.1056/NEJM200105313442203 1195:regulation of T cell anergy 1119:recycling endosome membrane 1094:MHC class I protein complex 1049:phagocytic vesicle membrane 4262: 4215:Cluster of differentiation 3100:10.1177/014107680409700102 2650:Current Molecular Medicine 1936: 1931: 1769: 1764: 1759: 1650:31,353,871 to 31,357,211 1114:secretory granule membrane 1023:signaling receptor binding 4205:Human blood group systems 3242: 2570:Annual Review of Medicine 2491:10.1007/s12015-014-9574-4 2354:"Human PubMed Reference:" 1836: 1553: 1548: 1544: 1537: 1518: 1501: 1488: 1467: 1456: 1443: 1422: 1411: 1400: 1396: 1381: 1377: 1368: 1357: 1353: 1338: 1312: 1303: 1292: 1288: 1273: 1269: 1260: 1245: 1238: 1234: 1218: 1008: 1004: 987: 978: 969: 956: 943: 939: 886: 877: 847: 839: 835: 818: 805: 768: 745: 736: 732: 703: 700: 690: 683: 678: 71: 66: 49: 44: 39: 35: 26: 21: 2727:Nature Reviews. Genetics 2662:10.2174/1566524043479293 2251:Stevens–Johnson syndrome 1210:neutrophil degranulation 4210:Cell adhesion molecules 4180:Human leukocyte antigen 2862:10.1073/pnas.0409500102 1692:more precise citations. 1646:at cytoband 21.3, from 1587:human leukocyte antigen 1507:Chr 6: 31.35 – 31.37 Mb 1059:early endosome membrane 1028:peptide antigen binding 902:upper lobe of left lung 4246:Drug-sensitivity genes 3044:10.1073/pnas.050567397 2907:10.1053/berh.2002.0243 2261:(a drug used to treat 2205:Ankylosing spondylitis 50:Human UniProt search: 2212:spondyloarthropathies 1155:immune system process 1109:extracellular exosome 1089:endoplasmic reticulum 762:Chromosome 6 (human) 67:List of PDB id codes 40:Available structures 3035:2000PNAS...97.2709M 2853:2005PNAS..102.4134H 2615:2004Natur.428..486C 2403:1991Natur.352..595H 1722: 926:epithelium of colon 3930:GeneCard for HLA-B 3074:2007-11-26 at the 2993:10.1038/nm0703-861 2272:Among people with 2228:reactive arthritis 2224:ulcerative colitis 1720: 1654:Related conditions 1128:Biological process 1037:Cellular component 1016:Molecular function 4223: 4222: 4190:Blood transfusion 3895: 3894: 2479:Stem Cell Reviews 2397:(6336): 595–600. 2202: 2201: 1718: 1717: 1710: 1561: 1560: 1557: 1556: 1533: 1532: 1497: 1496: 1478: 1477: 1452: 1451: 1433: 1432: 1407: 1406: 1390: 1389: 1364: 1363: 1347: 1346: 1299: 1298: 1282: 1281: 1230: 1229: 1000: 999: 996: 995: 965: 964: 952: 951: 933: 932: 910:bone marrow cells 831: 830: 726:HLA-B - orthologs 674: 673: 670: 669: 4253: 3987: 3980: 3973: 3964: 3881: 3866: 3851: 3836: 3821: 3806: 3791: 3776: 3761: 3746: 3731: 3716: 3701: 3686: 3671: 3656: 3641: 3626: 3611: 3596: 3581: 3566: 3551: 3536: 3521: 3506: 3491: 3476: 3461: 3446: 3431: 3416: 3401: 3386: 3371: 3356: 3341: 3326: 3311: 3296: 3281: 3266: 3251: 3231: 3224: 3217: 3208: 3197: 3159: 3121: 3111: 3066: 3056: 3046: 3013: 2995: 2965: 2939: 2918: 2884: 2874: 2864: 2831: 2806:(9312): 1121–2. 2793: 2783: 2758: 2739:10.1038/35103577 2716: 2706: 2673: 2644: 2626: 2593: 2560: 2513: 2512: 2502: 2470: 2464: 2463: 2461: 2459: 2439: 2433: 2432: 2414: 2412:10.1038/352595a0 2382: 2376: 2375: 2368: 2362: 2361: 2350: 2344: 2334: 2269:in the joints). 2239:Behçet's disease 1731: 1723: 1713: 1706: 1702: 1699: 1693: 1688:this article by 1679:inline citations 1666: 1665: 1658: 1546: 1545: 1529: 1514: 1509: 1492: 1482: 1473: 1461: 1457:RefSeq (protein) 1447: 1437: 1428: 1416: 1394: 1375: 1351: 1334: 1310: 1286: 1267: 1236: 1006: 992: 983: 976: 961: 937: 882: 880:Top expressed in 875: 854: 837: 827: 814: 803: 788: 781: 775: 764: 750: 734: 728: 695: 688: 665: 64: 58: 37: 36: 31: 19: 4261: 4260: 4256: 4255: 4254: 4252: 4251: 4250: 4226: 4225: 4224: 4219: 4168: 4040: 3997: 3991: 3909: 3896: 3891: 3888: 3882: 3873: 3867: 3858: 3852: 3843: 3837: 3828: 3822: 3813: 3807: 3798: 3792: 3783: 3777: 3768: 3762: 3753: 3747: 3738: 3732: 3723: 3717: 3708: 3702: 3693: 3687: 3678: 3672: 3663: 3657: 3648: 3642: 3633: 3627: 3618: 3612: 3603: 3597: 3588: 3582: 3573: 3567: 3558: 3552: 3543: 3537: 3528: 3522: 3513: 3507: 3498: 3492: 3483: 3477: 3468: 3462: 3453: 3447: 3438: 3432: 3423: 3417: 3408: 3402: 3393: 3387: 3378: 3372: 3363: 3357: 3348: 3342: 3333: 3327: 3318: 3312: 3303: 3297: 3288: 3282: 3273: 3267: 3258: 3252: 3238: 3235: 3205: 3162: 3124: 3081: 3076:Wayback Machine 3016: 2980:Nature Medicine 2973: 2968:Full text (PDF) 2937:10.1.1.694.2473 2930:(12): 896–907. 2921: 2892: 2834: 2796: 2774:(22): 1668–75. 2761: 2724: 2676: 2647: 2624:10.1038/428486a 2596: 2563: 2526: 2522: 2520:Further reading 2517: 2516: 2472: 2471: 2467: 2457: 2455: 2454:on 9 March 2014 2441: 2440: 2436: 2384: 2383: 2379: 2370: 2369: 2365: 2352: 2351: 2347: 2335: 2326: 2321: 2309: 2300: 2253:in response to 2220:Crohn's disease 1741:Split antigens 1736: 1729: 1714: 1703: 1697: 1694: 1684:Please help to 1683: 1667: 1663: 1656: 1550:View/Edit Human 1527: 1512: 1505: 1502:Location (UCSC) 1490: 1469: 1445: 1424: 1341:ENSG00000232126 1333: 1331:ENSG00000223532 1329: 1327:ENSG00000224608 1325: 1323:ENSG00000206450 1321: 1319:ENSG00000234745 1317: 1315:ENSG00000228964 1313: 1214: 1185:immune response 1123: 1074:plasma membrane 1054:Golgi apparatus 1032: 988: 957: 948: 929: 924: 920: 916: 912: 908: 904: 900: 896: 892: 878: 822: 809: 801: 791: 790: 789: 782: 760: 737:Gene location ( 704: 691: 684: 73: 51: 17: 12: 11: 5: 4259: 4257: 4249: 4248: 4243: 4238: 4228: 4227: 4221: 4220: 4218: 4217: 4212: 4207: 4202: 4197: 4192: 4187: 4182: 4176: 4174: 4170: 4169: 4167: 4166: 4165: 4164: 4159: 4154: 4149: 4144: 4134: 4133: 4132: 4127: 4122: 4117: 4112: 4102: 4101: 4100: 4095: 4085: 4084: 4083: 4078: 4068: 4067: 4066: 4061: 4050: 4048: 4042: 4041: 4039: 4038: 4033: 4028: 4023: 4018: 4013: 4007: 4005: 3999: 3998: 3992: 3990: 3989: 3982: 3975: 3967: 3961: 3960: 3939: 3933: 3932: 3927: 3919: 3908: 3907:External links 3905: 3893: 3892: 3890: 3889: 3883: 3876: 3874: 3868: 3861: 3859: 3853: 3846: 3844: 3838: 3831: 3829: 3823: 3816: 3814: 3808: 3801: 3799: 3793: 3786: 3784: 3778: 3771: 3769: 3763: 3756: 3754: 3748: 3741: 3739: 3733: 3726: 3724: 3718: 3711: 3709: 3703: 3696: 3694: 3688: 3681: 3679: 3673: 3666: 3664: 3658: 3651: 3649: 3643: 3636: 3634: 3628: 3621: 3619: 3613: 3606: 3604: 3598: 3591: 3589: 3583: 3576: 3574: 3568: 3561: 3559: 3553: 3546: 3544: 3538: 3531: 3529: 3523: 3516: 3514: 3508: 3501: 3499: 3493: 3486: 3484: 3478: 3471: 3469: 3463: 3456: 3454: 3448: 3441: 3439: 3433: 3426: 3424: 3418: 3411: 3409: 3403: 3396: 3394: 3388: 3381: 3379: 3373: 3366: 3364: 3358: 3351: 3349: 3343: 3336: 3334: 3328: 3321: 3319: 3313: 3306: 3304: 3298: 3291: 3289: 3283: 3276: 3274: 3268: 3261: 3259: 3253: 3246: 3243: 3240: 3239: 3236: 3234: 3233: 3226: 3219: 3211: 3204: 3203: 3200:Full text(PDF) 3160: 3122: 3079: 3029:(6): 2709–14. 3014: 2971: 2919: 2890: 2847:(11): 4134–9. 2832: 2794: 2759: 2733:(12): 967–77. 2722: 2674: 2645: 2594: 2561: 2523: 2521: 2518: 2515: 2514: 2465: 2442:Fix M (1998). 2434: 2377: 2363: 2345: 2323: 2322: 2320: 2317: 2316: 2315: 2308: 2305: 2299: 2296: 2200: 2199: 2195: 2194: 2192: 2190: 2188: 2186: 2184: 2178: 2177: 2175: 2173: 2171: 2169: 2167: 2161: 2160: 2158: 2156: 2154: 2152: 2150: 2144: 2143: 2141: 2139: 2137: 2135: 2133: 2127: 2126: 2124: 2122: 2120: 2118: 2116: 2110: 2109: 2107: 2105: 2103: 2101: 2099: 2093: 2092: 2090: 2088: 2086: 2084: 2082: 2076: 2075: 2073: 2071: 2069: 2067: 2065: 2059: 2058: 2056: 2054: 2052: 2050: 2048: 2042: 2041: 2039: 2037: 2035: 2033: 2031: 2025: 2024: 2022: 2017: 2012: 2005: 2003: 1997: 1996: 1991: 1986: 1981: 1974: 1972: 1966: 1965: 1963: 1958: 1953: 1946: 1944: 1938: 1937: 1935: 1930: 1925: 1918: 1916: 1910: 1909: 1907: 1902: 1897: 1890: 1888: 1882: 1881: 1876: 1871: 1866: 1864: 1858: 1857: 1852: 1847: 1842: 1835: 1833: 1827: 1826: 1824: 1819: 1814: 1807: 1805: 1799: 1798: 1796: 1791: 1786: 1779: 1777: 1771: 1770: 1768: 1763: 1758: 1751: 1749: 1743: 1742: 1739: 1732: 1727: 1716: 1715: 1698:September 2008 1670: 1668: 1661: 1655: 1652: 1559: 1558: 1555: 1554: 1552: 1542: 1541: 1535: 1534: 1531: 1530: 1525: 1523: 1516: 1515: 1510: 1503: 1499: 1498: 1495: 1494: 1486: 1485: 1479: 1476: 1475: 1465: 1464: 1458: 1454: 1453: 1450: 1449: 1441: 1440: 1434: 1431: 1430: 1420: 1419: 1413: 1409: 1408: 1405: 1404: 1398: 1397: 1391: 1388: 1387: 1379: 1378: 1372: 1366: 1365: 1362: 1361: 1355: 1354: 1348: 1345: 1344: 1336: 1335: 1307: 1301: 1300: 1297: 1296: 1290: 1289: 1283: 1280: 1279: 1271: 1270: 1264: 1258: 1257: 1252: 1247: 1243: 1242: 1232: 1231: 1228: 1227: 1216: 1215: 1213: 1212: 1207: 1202: 1197: 1192: 1187: 1182: 1177: 1172: 1167: 1162: 1157: 1152: 1147: 1142: 1137: 1131: 1129: 1125: 1124: 1122: 1121: 1116: 1111: 1106: 1101: 1096: 1091: 1086: 1081: 1076: 1071: 1069:Golgi membrane 1066: 1061: 1056: 1051: 1046: 1040: 1038: 1034: 1033: 1031: 1030: 1025: 1019: 1017: 1013: 1012: 1002: 1001: 998: 997: 994: 993: 985: 984: 973: 967: 966: 963: 962: 954: 953: 950: 949: 947: 944: 941: 940: 934: 931: 930: 928: 927: 923: 919: 915: 911: 907: 903: 899: 895: 891: 887: 884: 883: 871: 870: 862: 851: 845: 844: 841:RNA expression 833: 832: 829: 828: 820: 816: 815: 807: 804: 799: 793: 792: 783: 776: 770: 766: 765: 758: 752: 751: 743: 742: 730: 729: 702: 698: 697: 689: 681: 680: 676: 675: 672: 671: 668: 667: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 4258: 4247: 4244: 4242: 4241:HLA-B alleles 4239: 4237: 4234: 4233: 4231: 4216: 4213: 4211: 4208: 4206: 4203: 4201: 4198: 4196: 4193: 4191: 4188: 4186: 4183: 4181: 4178: 4177: 4175: 4171: 4163: 4160: 4158: 4155: 4153: 4150: 4148: 4145: 4143: 4140: 4139: 4138: 4135: 4131: 4128: 4126: 4123: 4121: 4118: 4116: 4113: 4111: 4108: 4107: 4106: 4103: 4099: 4096: 4094: 4091: 4090: 4089: 4086: 4082: 4079: 4077: 4074: 4073: 4072: 4069: 4065: 4062: 4060: 4057: 4056: 4055: 4052: 4051: 4049: 4047: 4043: 4037: 4034: 4032: 4029: 4027: 4024: 4022: 4019: 4017: 4014: 4012: 4009: 4008: 4006: 4004: 4000: 3995: 3988: 3983: 3981: 3976: 3974: 3969: 3968: 3965: 3958: 3954: 3953: 3948: 3944: 3940: 3938: 3935: 3934: 3931: 3928: 3926: 3923: 3920: 3918: 3914: 3911: 3910: 3906: 3904: 3903: 3902: 3886: 3880: 3875: 3871: 3865: 3860: 3856: 3850: 3845: 3841: 3835: 3830: 3826: 3820: 3815: 3811: 3805: 3800: 3796: 3790: 3785: 3781: 3775: 3770: 3766: 3760: 3755: 3751: 3745: 3740: 3736: 3730: 3725: 3721: 3715: 3710: 3706: 3700: 3695: 3691: 3685: 3680: 3676: 3670: 3665: 3661: 3655: 3650: 3646: 3640: 3635: 3631: 3625: 3620: 3616: 3610: 3605: 3601: 3595: 3590: 3586: 3580: 3575: 3571: 3565: 3560: 3556: 3550: 3545: 3541: 3535: 3530: 3526: 3520: 3515: 3511: 3505: 3500: 3496: 3490: 3485: 3481: 3475: 3470: 3466: 3460: 3455: 3451: 3445: 3440: 3436: 3430: 3425: 3421: 3415: 3410: 3406: 3400: 3395: 3391: 3385: 3380: 3376: 3370: 3365: 3361: 3355: 3350: 3346: 3340: 3335: 3331: 3325: 3320: 3316: 3310: 3305: 3301: 3295: 3290: 3286: 3280: 3275: 3271: 3265: 3260: 3256: 3250: 3245: 3241: 3232: 3227: 3225: 3220: 3218: 3213: 3212: 3209: 3202: 3201: 3195: 3191: 3187: 3183: 3179: 3175: 3172:(5): 926–30. 3171: 3167: 3161: 3157: 3153: 3149: 3145: 3141: 3137: 3133: 3129: 3123: 3119: 3115: 3110: 3105: 3101: 3097: 3093: 3089: 3085: 3080: 3078: 3077: 3073: 3070: 3064: 3060: 3055: 3050: 3045: 3040: 3036: 3032: 3028: 3024: 3020: 3015: 3011: 3007: 3003: 2999: 2994: 2989: 2985: 2981: 2977: 2972: 2970: 2969: 2963: 2959: 2955: 2951: 2947: 2943: 2938: 2933: 2929: 2925: 2920: 2916: 2912: 2908: 2904: 2901:(4): 675–90. 2900: 2896: 2891: 2889: 2888: 2882: 2878: 2873: 2868: 2863: 2858: 2854: 2850: 2846: 2842: 2838: 2833: 2829: 2825: 2821: 2817: 2813: 2809: 2805: 2801: 2795: 2791: 2787: 2782: 2777: 2773: 2769: 2765: 2760: 2756: 2752: 2748: 2744: 2740: 2736: 2732: 2728: 2723: 2721: 2720: 2714: 2710: 2705: 2700: 2696: 2692: 2689:(2): 348–69. 2688: 2684: 2680: 2675: 2671: 2667: 2663: 2659: 2655: 2651: 2646: 2642: 2638: 2634: 2630: 2625: 2620: 2616: 2612: 2609:(6982): 486. 2608: 2604: 2600: 2595: 2591: 2587: 2583: 2579: 2575: 2571: 2567: 2562: 2558: 2554: 2550: 2546: 2542: 2538: 2535:(4): 354–60. 2534: 2530: 2525: 2524: 2519: 2510: 2506: 2501: 2496: 2492: 2488: 2484: 2480: 2476: 2469: 2466: 2453: 2449: 2445: 2438: 2435: 2430: 2426: 2422: 2418: 2413: 2408: 2404: 2400: 2396: 2392: 2388: 2381: 2378: 2373: 2367: 2364: 2359: 2355: 2349: 2346: 2342: 2338: 2333: 2331: 2329: 2325: 2318: 2314: 2311: 2310: 2306: 2304: 2297: 2295: 2293: 2288: 2286: 2281: 2279: 2275: 2270: 2268: 2264: 2260: 2256: 2255:carbamazepine 2252: 2248: 2242: 2240: 2236: 2231: 2229: 2225: 2221: 2217: 2213: 2208: 2206: 2196: 2193: 2191: 2189: 2187: 2183: 2180: 2176: 2174: 2172: 2170: 2166: 2163: 2159: 2157: 2155: 2153: 2149: 2146: 2142: 2140: 2138: 2136: 2132: 2129: 2125: 2123: 2121: 2119: 2115: 2112: 2108: 2106: 2104: 2102: 2098: 2095: 2091: 2089: 2087: 2085: 2081: 2078: 2074: 2072: 2070: 2068: 2064: 2061: 2057: 2055: 2053: 2051: 2047: 2044: 2040: 2038: 2036: 2034: 2030: 2027: 2023: 2021: 2018: 2016: 2013: 2011: 2010: 2006: 2002: 1999: 1995: 1992: 1990: 1987: 1985: 1982: 1980: 1979: 1975: 1971: 1968: 1964: 1962: 1959: 1957: 1954: 1952: 1951: 1947: 1943: 1940: 1934: 1929: 1926: 1924: 1923: 1919: 1915: 1912: 1908: 1906: 1903: 1901: 1898: 1896: 1895: 1891: 1887: 1884: 1880: 1877: 1875: 1872: 1870: 1867: 1863: 1860: 1856: 1853: 1851: 1848: 1846: 1843: 1841: 1840: 1832: 1829: 1825: 1823: 1820: 1818: 1815: 1813: 1812: 1808: 1804: 1801: 1797: 1795: 1792: 1790: 1787: 1785: 1784: 1780: 1776: 1773: 1767: 1762: 1757: 1756: 1752: 1748: 1745: 1738: 1733: 1725: 1712: 1709: 1701: 1691: 1687: 1681: 1680: 1674: 1669: 1660: 1659: 1653: 1651: 1649: 1645: 1640: 1638: 1632: 1630: 1625: 1623: 1619: 1615: 1611: 1607: 1603: 1598: 1596: 1592: 1588: 1584: 1583:immune system 1580: 1576: 1573: 1569: 1565: 1551: 1547: 1543: 1540: 1536: 1526: 1524: 1521: 1517: 1511: 1508: 1504: 1500: 1493: 1487: 1483: 1480: 1474: 1472: 1466: 1462: 1459: 1455: 1448: 1442: 1438: 1435: 1429: 1427: 1421: 1417: 1414: 1412:RefSeq (mRNA) 1410: 1403: 1399: 1395: 1392: 1386: 1385: 1380: 1376: 1373: 1371: 1367: 1360: 1356: 1352: 1349: 1343: 1342: 1337: 1332: 1328: 1324: 1320: 1316: 1311: 1308: 1306: 1302: 1295: 1291: 1287: 1284: 1278: 1277: 1272: 1268: 1265: 1263: 1259: 1256: 1253: 1251: 1248: 1244: 1241: 1237: 1233: 1226: 1222: 1217: 1211: 1208: 1206: 1203: 1201: 1200:viral process 1198: 1196: 1193: 1191: 1188: 1186: 1183: 1181: 1178: 1176: 1173: 1171: 1168: 1166: 1163: 1161: 1158: 1156: 1153: 1151: 1148: 1146: 1143: 1141: 1138: 1136: 1133: 1132: 1130: 1127: 1126: 1120: 1117: 1115: 1112: 1110: 1107: 1105: 1102: 1100: 1097: 1095: 1092: 1090: 1087: 1085: 1082: 1080: 1077: 1075: 1072: 1070: 1067: 1065: 1062: 1060: 1057: 1055: 1052: 1050: 1047: 1045: 1042: 1041: 1039: 1036: 1035: 1029: 1026: 1024: 1021: 1020: 1018: 1015: 1014: 1011: 1010:Gene ontology 1007: 1003: 991: 986: 982: 977: 974: 972: 968: 960: 955: 945: 942: 938: 935: 925: 921: 917: 913: 909: 905: 901: 897: 893: 889: 888: 885: 881: 876: 873: 872: 869: 867: 863: 861: 860: 856: 855: 852: 850: 846: 842: 838: 834: 826: 821: 817: 813: 808: 798: 794: 787: 780: 774: 767: 763: 757: 753: 749: 744: 740: 735: 731: 727: 723: 719: 715: 711: 707: 699: 694: 687: 682: 677: 666: 664: 660: 656: 652: 648: 644: 640: 636: 632: 628: 624: 620: 616: 612: 608: 604: 600: 596: 592: 588: 584: 580: 576: 572: 568: 564: 560: 556: 552: 548: 544: 540: 536: 532: 528: 524: 520: 516: 512: 508: 504: 500: 496: 492: 488: 484: 480: 476: 472: 468: 464: 460: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 416: 412: 408: 404: 400: 396: 392: 388: 384: 380: 376: 372: 368: 364: 360: 356: 352: 348: 344: 340: 336: 332: 328: 324: 320: 316: 312: 308: 304: 300: 296: 292: 288: 284: 280: 276: 272: 268: 264: 260: 256: 252: 248: 244: 240: 236: 232: 228: 224: 220: 216: 212: 208: 204: 200: 196: 192: 188: 184: 180: 176: 172: 168: 164: 160: 156: 152: 148: 144: 140: 136: 132: 128: 124: 120: 116: 112: 108: 104: 100: 96: 92: 88: 84: 80: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 4046:MHC class II 4015: 3950: 3898: 3897: 3884: 3869: 3854: 3839: 3824: 3809: 3794: 3779: 3764: 3749: 3734: 3719: 3704: 3689: 3674: 3659: 3644: 3629: 3614: 3599: 3584: 3569: 3554: 3539: 3524: 3509: 3494: 3479: 3464: 3449: 3434: 3419: 3404: 3389: 3374: 3359: 3344: 3329: 3314: 3299: 3284: 3269: 3254: 3198: 3169: 3165: 3134:(9): 704–9. 3131: 3127: 3091: 3087: 3067: 3026: 3022: 2986:(7): 861–6. 2983: 2979: 2966: 2927: 2923: 2898: 2894: 2885: 2844: 2840: 2803: 2799: 2771: 2767: 2730: 2726: 2717: 2686: 2682: 2656:(1): 21–30. 2653: 2649: 2606: 2602: 2573: 2569: 2532: 2528: 2482: 2478: 2468: 2456:. Retrieved 2452:the original 2447: 2437: 2394: 2390: 2380: 2372:"HLA-B gene" 2366: 2357: 2348: 2301: 2289: 2282: 2271: 2243: 2232: 2209: 2203: 2007: 1976: 1948: 1920: 1892: 1837: 1809: 1781: 1753: 1734: 1704: 1695: 1676: 1644:chromosome 6 1641: 1633: 1626: 1599: 1567: 1563: 1562: 1489: 1468: 1444: 1423: 1401: 1382: 1358: 1339: 1293: 1274: 1254: 1249: 1084:cell surface 864: 857: 701:External IDs 72: 4200:Calgranulin 4003:MHC class I 3237:PDB gallery 3094:(1): 10–4. 2485:(1): 1–10. 2259:allopurinol 2247:Han Chinese 1690:introducing 898:granulocyte 823:31,367,067 810:31,353,872 679:Identifiers 4230:Categories 3922:EntrezGene 2576:: 535–51. 2343:, May 2017 2319:References 1673:references 922:lymph node 914:right lung 868:(ortholog) 706:HomoloGene 3166:Epilepsia 3069:Full text 2932:CiteSeerX 2887:Full text 2719:Full text 2267:uric acid 2216:psoriasis 1648:base pair 1614:class III 1471:NP_005505 1426:NM_005514 1240:Orthologs 714:GeneCards 4195:Arrestin 3915:(OMIM): 3194:27093314 3186:20345939 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Index


PDB
PDBe
RCSB
3VCL
4U1H
4U1K
5EO1
5EO0
1AGB
1AGC
1AGD
1AGE
1AGF
1M05
1MI5
3FFC
3SJV
3SKM
3SKO
3SPV
3X13
3X14
4QRP
4QRQ
4QRS
4QRT
4QRU
4O2C
4O2E

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