2387:
316:
2567:
293:
2267:
2207:
2192:
2342:
2312:
2297:
2147:
2582:
2282:
190:
215:
2222:
2552:
2357:
2372:
2507:
2177:
2237:
2537:
2522:
2477:
2327:
2417:
2432:
2252:
2162:
2462:
2447:
322:
221:
2492:
2402:
2870:
31:
57:
1223:
and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
2386:
2566:
2266:
2206:
2191:
2341:
2311:
2296:
1587:"Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules"
2146:
1448:
Nong Y, Kandil O, Tobin EH, et al. (1991). "The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1".
2581:
2281:
2221:
2551:
2356:
2371:
2506:
2395:: Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
2176:
2236:
2536:
2521:
2476:
2326:
54:
2416:
2431:
2251:
329:
228:
2575:: Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3--L-alanine) and the Superantigen, SEC3 Variant 3B2
1164:. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the
2161:
151:
851:
832:
2461:
2034:"Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes"
1958:
Owerbach D, Rich C, Taneja K (1986). "Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient".
1722:"HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes"
2911:
2622:
2446:
2126:
1995:
Wu S, Saunders TL, Bach FH (1987). "Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci".
1313:
1548:
Petersdorf EW, Griffith RL, Erlich HA, et al. (1990). "Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes".
1295:
2930:
2491:
315:
2275:: Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4
2215:: CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1
2200:: STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES
1078:
1071:
292:
2350:: Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
2320:: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2
2305:: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the Superantigen SEC3 Variant 3B1
2822:
2631:
2401:
1338:
1876:
Freeman SM, Saunders TL, Madden M, et al. (1987). "Comparison of DR beta 1 alleles from diabetic and normal individuals".
1282:
1261:
1411:
Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120".
2155:: HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE
1278:
214:
189:
1257:
2590:: Mycoplasma arthritidis-derived mitogen complexed with class II MHC molecule HLA-DR1/HA complex in the presence of EDTA
328:
227:
131:
2290:: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3
1204:
have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
321:
220:
2230:: X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE
2904:
2852:
2615:
2067:
Steimle V, Hinkkanen A, Schlesier M, Epplen JT (1988). "A novel HLA-DR beta I sequence from the DRw11 haplotype".
2842:
2119:
896:
139:
2560:: Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
2365:: Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
1683:
Lee KW, Johnson AH, Hurley CK (1990). "Two divergent routes of evolution gave rise to the DRw13 haplotypes".
2817:
1169:
877:
2380:: Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II
2935:
2847:
1197:
2897:
2608:
1189:
2515:: Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule
2185:: CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE
2245:: CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II
2112:
1918:
1768:
1643:
203:
118:
2545:: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
2530:: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
2092:
2020:
1983:
1794:
1708:
1573:
1436:
1399:
163:
1515:"Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor"
1168:
by presenting peptides derived from extracellular proteins. Class II molecules are expressed in
1054:
1033:
1007:
986:
2827:
2084:
2055:
2012:
1975:
1946:
1893:
1864:
1829:
1786:
1743:
1700:
1671:
1618:
1565:
1536:
1501:
1466:
1428:
1391:
1362:
159:
111:
47:
2881:
2485:: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2
2335:: Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1
1808:"The DR3(w18),DQw4 haplotype differs from DR3(w17),DQw2 haplotypes at multiple class II loci"
1632:"Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates"
1374:
Dong RP, Kimura A, Sasazuki T (1992). "Sequence analysis of three novel DRw14-DRB1 alleles".
2076:
2045:
2004:
1967:
1936:
1926:
1885:
1854:
1819:
1776:
1733:
1692:
1661:
1651:
1608:
1598:
1557:
1526:
1491:
1458:
1420:
1383:
408:
339:
283:
238:
2600:
2425:: COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB
2789:
383:
752:
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
2440:: HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation
1922:
1772:
1757:"Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding"
1647:
1185:
2260:: CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II
1941:
1906:
766:
761:
756:
751:
746:
741:
736:
731:
726:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
599:
2924:
1889:
1824:
1807:
1666:
1631:
1613:
1586:
1462:
1165:
586:
1987:
1712:
1577:
1440:
1403:
2683:
2096:
2024:
1798:
1157:
401:
180:
1184:, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
143:
2050:
2033:
1859:
1842:
732:
antigen processing and presentation of exogenous peptide antigen via MHC class II
167:
2837:
2640:
1696:
1531:
1514:
1318:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1300:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1738:
1721:
1496:
1479:
484:
1161:
300:
197:
147:
1339:"Entrez Gene: HLA-DRB5 major histocompatibility complex, class II, DR beta 5"
1931:
1603:
1193:
796:
544:
422:
367:
354:
266:
253:
155:
1656:
122:, HLA-DRB, major histocompatibility complex, class II, DR beta 5, HLA-DRB5*
2088:
2059:
2016:
1979:
1950:
1907:"HLA-DR2 subtypes form an additional supertypic family of DR beta alleles"
1897:
1868:
1833:
1790:
1747:
1704:
1675:
1622:
1569:
1540:
1505:
1470:
1432:
1395:
1366:
1118:
1113:
2832:
2794:
2784:
2767:
2762:
2757:
2752:
2747:
2735:
2730:
1357:
Lau M, Terasaki PI, Park MS (1995). "International Cell
Exchange, 1994".
1220:
1216:
1212:
1102:
953:
949:
945:
941:
937:
922:
2877:
2779:
2718:
2713:
2701:
2696:
2080:
1971:
1843:"Inhibition of CD4+ T cell function by the HIV envelope protein, gp120"
1561:
1424:
1387:
1153:
1134:
908:
863:
2869:
88:
84:
80:
76:
2774:
2742:
2725:
2708:
2691:
2008:
1781:
1756:
1233:
1201:
1086:
818:
701:
integral component of lumenal side of endoplasmic reticulum membrane
2170:: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB
2673:
2668:
2663:
2658:
2653:
2648:
781:
777:
1181:
1141:
135:
2604:
2470:: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)
2108:
1200:
specifying the peptide binding specificities. Hundreds of DRB1
30:
2104:
1215:
is expressed at a level five times higher than its paralogues
1180:
The beta chain is approximately 26-28 kDa. It is encoded by 6
1196:
tail. Within the DR molecule the beta chain contains all the
1585:
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991).
2455:: HLA-DR1 complexed with a 13 residue HIV capsid peptide
1841:
Diamond DC, Sleckman BP, Gregory T, et al. (1988).
1480:"HIV-gp120 can block CD4-class II MHC-mediated adhesion"
1131:
HLA class II histocompatibility antigen, DRB5 beta chain
391:
2885:
1806:
Hurley CK, Gregersen PK, Gorski J, et al. (1989).
556:
2500:: Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a
1172:(APC: B lymphocytes, dendritic cells, macrophages).
2810:
2682:
2639:
1905:Lee BS, Rust NA, McMichael AJ, McDevitt HO (1987).
1513:Callahan KM, Fort MM, Obah EA, et al. (1990).
1047:
1026:
1000:
979:
1755:Clayton LK, Sieh M, Pious DA, Reinherz EL (1989).
1333:
1331:
1329:
1327:
1274:
1272:
1270:
1253:
1251:
1249:
338:
237:
1478:Rosenstein Y, Burakoff SJ, Herrmann SH (1990).
18:Protein-coding gene in the species Homo sapiens
1279:GRCm38: Ensembl release 89: ENSMUSG00000060586
2905:
2616:
2120:
1630:Gyllensten UB, Sundvall M, Erlich HA (1991).
8:
1258:GRCh38: Ensembl release 89: ENSG00000198502
737:interferon-gamma-mediated signaling pathway
2912:
2898:
2623:
2609:
2601:
2410:: Crystal structure of the MAM-MHC complex
2127:
2113:
2105:
932:
792:
626:clathrin-coated endocytic vesicle membrane
582:
379:
278:
175:
65:
2049:
1940:
1930:
1858:
1823:
1780:
1737:
1665:
1655:
1612:
1602:
1530:
1495:
2142:
1245:
691:ER to Golgi transport vesicle membrane
20:
343:
304:
299:
242:
201:
196:
7:
2866:
2864:
1156:encoded by this gene belongs to the
727:antigen processing and presentation
2884:. You can help Knowledge (XXG) by
1044:
1023:
997:
976:
913:
887:
868:
842:
823:
561:
479:
417:
396:
14:
1137:that in humans is encoded by the
762:T cell receptor signaling pathway
2868:
2823:Minor histocompatibility antigen
2632:Major histocompatibility complex
2580:
2565:
2550:
2535:
2520:
2505:
2490:
2475:
2460:
2445:
2430:
2415:
2400:
2385:
2370:
2355:
2340:
2325:
2310:
2295:
2280:
2265:
2250:
2235:
2220:
2205:
2190:
2175:
2160:
2145:
1176:Gene structure and polymorphisms
327:
320:
314:
291:
226:
219:
213:
188:
29:
2032:Liu CP, Bach FH, Wu SK (1988).
1192:domain and exon 5 encodes the
646:endoplasmic reticulum membrane
616:integral component of membrane
545:More reference expression data
469:olfactory zone of nasal mucosa
1:
312:
211:
2051:10.4049/jimmunol.140.10.3631
1911:Proc. Natl. Acad. Sci. U.S.A
1890:10.1016/0198-8859(87)90033-4
1860:10.4049/jimmunol.141.11.3715
1825:10.1016/0198-8859(89)90068-2
1636:Proc. Natl. Acad. Sci. U.S.A
1591:Proc. Natl. Acad. Sci. U.S.A
1463:10.1016/0008-8749(91)90002-S
676:MHC class II protein complex
641:trans-Golgi network membrane
2931:Genes on human chromosome 6
1697:10.4049/jimmunol.145.9.3119
1532:10.4049/jimmunol.144.9.3341
2952:
2863:
2853:Cluster of differentiation
1739:10.4049/jimmunol.143.1.329
1497:10.4049/jimmunol.144.2.526
671:transport vesicle membrane
621:endocytic vesicle membrane
2843:Human blood group systems
2140:
1314:"Mouse PubMed Reference:"
1296:"Human PubMed Reference:"
1117:
1112:
1108:
1101:
1085:
1066:
1051:
1030:
1019:
1004:
983:
972:
961:
935:
920:
916:
907:
894:
890:
875:
871:
862:
849:
845:
830:
826:
817:
802:
795:
791:
775:
585:
581:
569:
564:
555:
542:
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
73:
68:
51:
46:
41:
37:
28:
23:
1170:antigen-presenting cells
1079:Chr 17: 34.52 – 34.54 Mb
767:adaptive immune response
2848:Cell adhesion molecules
2818:Human leukocyte antigen
1932:10.1073/pnas.84.13.4591
1604:10.1073/pnas.87.22.9052
1072:Chr 6: 32.52 – 32.53 Mb
600:peptide antigen binding
453:upper lobe of left lung
2880:-related article is a
1657:10.1073/pnas.88.9.3686
656:late endosome membrane
495:mesenteric lymph nodes
345:17 B1|17 17.98 cM
1188:, exon 4 encodes the
742:immune system process
711:extracellular exosome
686:endoplasmic reticulum
457:right coronary artery
306:Chromosome 17 (mouse)
1359:Clinical Transplants
747:T cell costimulation
523:white adipose tissue
204:Chromosome 6 (human)
168:HLA-DRB5 - orthologs
69:List of PDB id codes
42:Available structures
1923:1987PNAS...84.4591L
1773:1989Natur.339..548C
1648:1991PNAS...88.3686G
507:submandibular gland
2081:10.1007/BF00375861
1972:10.1007/BF00372296
1562:10.1007/BF00210446
1425:10.1007/BF00211424
1388:10.1007/BF00215291
897:ENSMUSG00000060586
720:Biological process
681:lysosomal membrane
609:Cellular component
593:Molecular function
531:tibiofemoral joint
2893:
2892:
2861:
2860:
2828:Blood transfusion
2598:
2597:
1720:Gorski J (1989).
1128:
1127:
1124:
1123:
1097:
1096:
1062:
1061:
1041:
1040:
1015:
1014:
994:
993:
968:
967:
929:
928:
903:
902:
884:
883:
858:
857:
839:
838:
787:
786:
706:endosome membrane
577:
576:
573:
572:
551:
550:
538:
537:
476:
475:
374:
373:
273:
272:
100:
99:
96:
95:
52:Ortholog search:
2943:
2914:
2907:
2900:
2872:
2865:
2625:
2618:
2611:
2602:
2584:
2569:
2554:
2539:
2524:
2509:
2494:
2479:
2464:
2449:
2434:
2419:
2404:
2389:
2374:
2359:
2344:
2329:
2314:
2299:
2284:
2269:
2254:
2239:
2224:
2209:
2194:
2179:
2164:
2149:
2129:
2122:
2115:
2106:
2100:
2063:
2053:
2028:
2009:10.1038/324676a0
1991:
1954:
1944:
1934:
1901:
1872:
1862:
1837:
1827:
1802:
1784:
1782:10.1038/339548a0
1767:(6225): 548–51.
1751:
1741:
1716:
1679:
1669:
1659:
1626:
1616:
1606:
1581:
1544:
1534:
1509:
1499:
1474:
1444:
1407:
1370:
1343:
1342:
1335:
1322:
1321:
1310:
1304:
1303:
1292:
1286:
1276:
1265:
1255:
1110:
1109:
1081:
1074:
1057:
1045:
1036:
1024:
1020:RefSeq (protein)
1010:
998:
989:
977:
957:
933:
914:
888:
869:
843:
824:
793:
583:
562:
547:
487:
485:Top expressed in
480:
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
121:
114:
91:
66:
60:
39:
38:
33:
21:
2951:
2950:
2946:
2945:
2944:
2942:
2941:
2940:
2921:
2920:
2919:
2918:
2862:
2857:
2806:
2678:
2635:
2629:
2599:
2594:
2591:
2585:
2576:
2570:
2561:
2555:
2546:
2540:
2531:
2525:
2516:
2510:
2501:
2495:
2486:
2480:
2471:
2465:
2456:
2450:
2441:
2435:
2426:
2420:
2411:
2405:
2396:
2390:
2381:
2375:
2366:
2360:
2351:
2345:
2336:
2330:
2321:
2315:
2306:
2300:
2291:
2285:
2276:
2270:
2261:
2255:
2246:
2240:
2231:
2225:
2216:
2210:
2201:
2195:
2186:
2180:
2171:
2165:
2156:
2150:
2136:
2133:
2103:
2066:
2031:
2003:(6098): 676–9.
1994:
1957:
1904:
1875:
1840:
1805:
1754:
1719:
1682:
1629:
1584:
1547:
1512:
1477:
1447:
1410:
1373:
1356:
1352:
1350:Further reading
1347:
1346:
1337:
1336:
1325:
1312:
1311:
1307:
1294:
1293:
1289:
1277:
1268:
1256:
1247:
1242:
1230:
1210:
1208:Gene expression
1178:
1150:
1119:View/Edit Mouse
1114:View/Edit Human
1077:
1070:
1067:Location (UCSC)
1053:
1032:
1006:
985:
956:
952:
948:
944:
940:
936:
878:ENSG00000198502
771:
757:immune response
715:
666:plasma membrane
636:Golgi apparatus
604:
543:
534:
529:
527:right lung lobe
525:
521:
517:
513:
509:
505:
501:
497:
483:
472:
467:
463:
459:
455:
451:
447:
443:
439:
435:
421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
75:
53:
19:
12:
11:
5:
2949:
2947:
2939:
2938:
2933:
2923:
2922:
2917:
2916:
2909:
2902:
2894:
2891:
2890:
2873:
2859:
2858:
2856:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2814:
2812:
2808:
2807:
2805:
2804:
2803:
2802:
2797:
2792:
2787:
2782:
2772:
2771:
2770:
2765:
2760:
2755:
2750:
2740:
2739:
2738:
2733:
2723:
2722:
2721:
2716:
2706:
2705:
2704:
2699:
2688:
2686:
2680:
2679:
2677:
2676:
2671:
2666:
2661:
2656:
2651:
2645:
2643:
2637:
2636:
2630:
2628:
2627:
2620:
2613:
2605:
2596:
2595:
2593:
2592:
2586:
2579:
2577:
2571:
2564:
2562:
2556:
2549:
2547:
2541:
2534:
2532:
2526:
2519:
2517:
2511:
2504:
2502:
2496:
2489:
2487:
2481:
2474:
2472:
2466:
2459:
2457:
2451:
2444:
2442:
2436:
2429:
2427:
2421:
2414:
2412:
2406:
2399:
2397:
2391:
2384:
2382:
2376:
2369:
2367:
2361:
2354:
2352:
2346:
2339:
2337:
2331:
2324:
2322:
2316:
2309:
2307:
2301:
2294:
2292:
2286:
2279:
2277:
2271:
2264:
2262:
2256:
2249:
2247:
2241:
2234:
2232:
2226:
2219:
2217:
2211:
2204:
2202:
2196:
2189:
2187:
2181:
2174:
2172:
2166:
2159:
2157:
2151:
2144:
2141:
2138:
2137:
2134:
2132:
2131:
2124:
2117:
2109:
2102:
2101:
2069:Immunogenetics
2064:
2044:(10): 3631–9.
2029:
1992:
1960:Immunogenetics
1955:
1917:(13): 4591–5.
1902:
1873:
1853:(11): 3715–7.
1838:
1803:
1752:
1717:
1691:(9): 3119–25.
1680:
1642:(9): 3686–90.
1627:
1597:(22): 9052–6.
1582:
1550:Immunogenetics
1545:
1510:
1475:
1445:
1413:Immunogenetics
1408:
1376:Immunogenetics
1371:
1353:
1351:
1348:
1345:
1344:
1323:
1305:
1287:
1266:
1244:
1243:
1241:
1238:
1237:
1236:
1229:
1226:
1209:
1206:
1177:
1174:
1149:
1146:
1126:
1125:
1122:
1121:
1116:
1106:
1105:
1099:
1098:
1095:
1094:
1092:
1090:
1083:
1082:
1075:
1068:
1064:
1063:
1060:
1059:
1049:
1048:
1042:
1039:
1038:
1028:
1027:
1021:
1017:
1016:
1013:
1012:
1002:
1001:
995:
992:
991:
981:
980:
974:
970:
969:
966:
965:
959:
958:
930:
927:
926:
918:
917:
911:
905:
904:
901:
900:
892:
891:
885:
882:
881:
873:
872:
866:
860:
859:
856:
855:
847:
846:
840:
837:
836:
828:
827:
821:
815:
814:
809:
804:
800:
799:
789:
788:
785:
784:
773:
772:
770:
769:
764:
759:
754:
749:
744:
739:
734:
729:
723:
721:
717:
716:
714:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
661:Golgi membrane
658:
653:
648:
643:
638:
633:
628:
623:
618:
612:
610:
606:
605:
603:
602:
596:
594:
590:
589:
579:
578:
575:
574:
571:
570:
567:
566:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2948:
2937:
2936:Protein stubs
2934:
2932:
2929:
2928:
2926:
2915:
2910:
2908:
2903:
2901:
2896:
2895:
2889:
2887:
2883:
2879:
2874:
2871:
2867:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2815:
2813:
2809:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2777:
2776:
2773:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2745:
2744:
2741:
2737:
2734:
2732:
2729:
2728:
2727:
2724:
2720:
2717:
2715:
2712:
2711:
2710:
2707:
2703:
2700:
2698:
2695:
2694:
2693:
2690:
2689:
2687:
2685:
2681:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2646:
2644:
2642:
2638:
2633:
2626:
2621:
2619:
2614:
2612:
2607:
2606:
2603:
2589:
2583:
2578:
2574:
2568:
2563:
2559:
2553:
2548:
2544:
2538:
2533:
2529:
2523:
2518:
2514:
2508:
2503:
2499:
2493:
2488:
2484:
2478:
2473:
2469:
2463:
2458:
2454:
2448:
2443:
2439:
2433:
2428:
2424:
2418:
2413:
2409:
2403:
2398:
2394:
2388:
2383:
2379:
2373:
2368:
2364:
2358:
2353:
2349:
2343:
2338:
2334:
2328:
2323:
2319:
2313:
2308:
2304:
2298:
2293:
2289:
2283:
2278:
2274:
2268:
2263:
2259:
2253:
2248:
2244:
2238:
2233:
2229:
2223:
2218:
2214:
2208:
2203:
2199:
2193:
2188:
2184:
2178:
2173:
2169:
2163:
2158:
2154:
2148:
2143:
2139:
2130:
2125:
2123:
2118:
2116:
2111:
2110:
2107:
2098:
2094:
2090:
2086:
2082:
2078:
2075:(3): 208–10.
2074:
2070:
2065:
2061:
2057:
2052:
2047:
2043:
2039:
2035:
2030:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1965:
1961:
1956:
1952:
1948:
1943:
1938:
1933:
1928:
1924:
1920:
1916:
1912:
1908:
1903:
1899:
1895:
1891:
1887:
1883:
1879:
1874:
1870:
1866:
1861:
1856:
1852:
1848:
1844:
1839:
1835:
1831:
1826:
1821:
1817:
1813:
1809:
1804:
1800:
1796:
1792:
1788:
1783:
1778:
1774:
1770:
1766:
1762:
1758:
1753:
1749:
1745:
1740:
1735:
1732:(1): 329–33.
1731:
1727:
1723:
1718:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1681:
1677:
1673:
1668:
1663:
1658:
1653:
1649:
1645:
1641:
1637:
1633:
1628:
1624:
1620:
1615:
1610:
1605:
1600:
1596:
1592:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1556:(2): 96–103.
1555:
1551:
1546:
1542:
1538:
1533:
1528:
1525:(9): 3341–6.
1524:
1520:
1516:
1511:
1507:
1503:
1498:
1493:
1490:(2): 526–31.
1489:
1485:
1481:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1451:Cell. Immunol
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1409:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1377:
1372:
1368:
1364:
1360:
1355:
1354:
1349:
1340:
1334:
1332:
1330:
1328:
1324:
1319:
1315:
1309:
1306:
1301:
1297:
1291:
1288:
1284:
1280:
1275:
1273:
1271:
1267:
1263:
1259:
1254:
1252:
1250:
1246:
1239:
1235:
1232:
1231:
1227:
1225:
1222:
1218:
1214:
1207:
1205:
1203:
1199:
1198:polymorphisms
1195:
1191:
1190:transmembrane
1187:
1183:
1175:
1173:
1171:
1167:
1166:immune system
1163:
1159:
1155:
1147:
1145:
1143:
1140:
1136:
1132:
1120:
1115:
1111:
1107:
1104:
1100:
1093:
1091:
1088:
1084:
1080:
1076:
1073:
1069:
1065:
1058:
1056:
1050:
1046:
1043:
1037:
1035:
1029:
1025:
1022:
1018:
1011:
1009:
1003:
999:
996:
990:
988:
982:
978:
975:
973:RefSeq (mRNA)
971:
964:
960:
955:
951:
947:
943:
939:
934:
931:
925:
924:
919:
915:
912:
910:
906:
899:
898:
893:
889:
886:
880:
879:
874:
870:
867:
865:
861:
854:
853:
848:
844:
841:
835:
834:
829:
825:
822:
820:
816:
813:
810:
808:
805:
801:
798:
794:
790:
783:
779:
774:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
724:
722:
719:
718:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
613:
611:
608:
607:
601:
598:
597:
595:
592:
591:
588:
587:Gene ontology
584:
580:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
2886:expanding it
2875:
2799:
2684:MHC class II
2587:
2572:
2557:
2542:
2527:
2512:
2497:
2482:
2467:
2452:
2437:
2422:
2407:
2392:
2377:
2362:
2347:
2332:
2317:
2302:
2287:
2272:
2257:
2242:
2227:
2212:
2197:
2182:
2167:
2152:
2072:
2068:
2041:
2037:
2000:
1996:
1963:
1959:
1914:
1910:
1881:
1878:Hum. Immunol
1877:
1850:
1846:
1818:(1): 37–50.
1815:
1812:Hum. Immunol
1811:
1764:
1760:
1729:
1725:
1688:
1684:
1639:
1635:
1594:
1590:
1553:
1549:
1522:
1518:
1487:
1483:
1454:
1450:
1419:(2): 121–8.
1416:
1412:
1382:(2): 130–3.
1379:
1375:
1358:
1317:
1308:
1299:
1290:
1211:
1179:
1158:HLA class II
1151:
1138:
1130:
1129:
1052:
1031:
1005:
984:
962:
921:
895:
876:
850:
831:
811:
806:
511:carotid body
407:
400:
127:External IDs
74:
15:
2838:Calgranulin
2641:MHC class I
2135:PDB gallery
1966:(1): 41–6.
1457:(1): 10–6.
1194:cytoplasmic
1160:beta chain
433:granulocyte
366:34,535,648
353:34,524,841
265:32,530,287
252:32,517,353
105:Identifiers
2925:Categories
2038:J. Immunol
1884:(1): 1–6.
1847:J. Immunol
1726:J. Immunol
1685:J. Immunol
1519:J. Immunol
1484:J. Immunol
1361:: 467–88.
1285:, May 2017
1264:, May 2017
1240:References
1162:paralogues
515:right lung
465:right lung
437:lymph node
411:(ortholog)
148:HomoloGene
1055:NP_034512
1034:NP_002116
1008:NM_010382
987:NM_002125
797:Orthologs
156:GeneCards
2833:Arrestin
1988:19599710
1713:19868100
1578:28007432
1441:10116507
1404:32928324
1281:–
1260:–
1228:See also
1148:Function
1139:HLA-DRB5
1103:Wikidata
776:Sources:
696:lysosome
651:membrane
631:endosome
449:monocyte
445:duodenum
441:appendix
160:HLA-DRB5
119:HLA-DRB5
24:HLA-DRB5
2878:protein
2634:classes
2097:2712069
2089:3137159
2060:3129499
2025:4365990
2017:3099214
1980:3015788
1951:2885840
1919:Bibcode
1898:2884201
1869:2846691
1834:2565895
1799:4246781
1791:2543930
1769:Bibcode
1748:2471740
1705:2212675
1676:2023919
1644:Bibcode
1623:1978941
1570:1975801
1541:1970352
1506:1967269
1471:1905983
1433:1869305
1396:1612646
1367:7547576
1283:Ensembl
1262:Ensembl
1202:alleles
1186:domains
1154:protein
1135:protein
909:UniProt
864:Ensembl
803:Species
782:QuickGO
386:pattern
244:6p21.32
112:Aliases
2775:HLA-DR
2743:HLA-DQ
2726:HLA-DP
2709:HLA-DO
2692:HLA-DM
2095:
2087:
2058:
2023:
2015:
1997:Nature
1986:
1978:
1949:
1942:305136
1939:
1896:
1867:
1832:
1797:
1789:
1761:Nature
1746:
1711:
1703:
1674:
1664:
1621:
1611:
1576:
1568:
1539:
1504:
1469:
1439:
1431:
1402:
1394:
1365:
1234:HLA-DR
1089:search
1087:PubMed
954:O78196
950:P18469
946:P18468
942:P04230
938:P04231
923:Q30154
819:Entrez
557:BioGPS
503:thymus
499:spleen
461:spleen
152:101524
136:604776
2876:This
2811:Other
2674:HLA-G
2669:HLA-F
2664:HLA-E
2659:HLA-C
2654:HLA-B
2649:HLA-A
2093:S2CID
2021:S2CID
1984:S2CID
1795:S2CID
1709:S2CID
1667:51517
1614:55099
1574:S2CID
1437:S2CID
1400:S2CID
1182:exons
1133:is a
852:14969
812:Mouse
807:Human
778:Amigo
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
144:95901
2882:stub
2588:2oje
2573:2ipk
2558:2icw
2543:2ian
2528:2iam
2513:2g9h
2498:1zgl
2483:1t5x
2468:1t5w
2453:1sjh
2438:1sje
2423:1seb
2408:1r5i
2393:1pyw
2378:1lo5
2363:1klu
2348:1klg
2333:1kg0
2318:1jwu
2303:1jws
2288:1jwm
2273:1j8h
2258:1hxy
2243:1hqr
2228:1h15
2213:1fyt
2198:1fv1
2183:1dlh
2168:1d5m
2153:1aqd
2085:PMID
2056:PMID
2013:PMID
1976:PMID
1947:PMID
1894:PMID
1865:PMID
1830:PMID
1787:PMID
1744:PMID
1701:PMID
1672:PMID
1619:PMID
1566:PMID
1537:PMID
1502:PMID
1467:PMID
1429:PMID
1392:PMID
1363:PMID
1221:DRB4
1217:DRB3
1213:DRB1
1152:The
1142:gene
833:3127
392:Bgee
340:Band
301:Chr.
239:Band
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