2398:
558:
2533:
2608:
535:
2278:
2218:
2203:
2353:
2323:
2308:
2098:
2623:
2293:
432:
457:
2233:
2593:
2368:
2113:
2383:
2548:
2188:
2248:
2578:
2563:
2488:
2338:
2428:
2443:
2263:
2638:
2143:
2158:
2128:
2173:
2473:
2458:
564:
463:
2518:
2413:
2503:
2926:
29:
55:
1891:
Gaig C, Graus F, Compta Y, Högl B, Bataller L, Brüggemann N, Giordana C, Heidbreder A, Kotschet K, Lewerenz J, Macher S, Martí MJ, Montojo T, Pérez-Pérez J, Puertas I, Seitz C, Simabukuro M, Téllez N, Wandinger KP, Iranzo A, Ercilla G, Sabater L, Santamaría J, Dalmau J (May 2017).
2397:
2532:
2607:
2277:
2217:
2202:
2352:
2322:
2307:
1782:
Raychaudhuri, S; Sandor, C; Stahl, EA; Freudenberg, J; Lee, HS; Jia, X; Alfredsson, L; Padyukov, L; Klareskog, L; Worthington, J; Siminovitch, KA; Bae, SC; Plenge, RM; Gregersen, PK; de Bakker, PI (29 January 2012).
2097:
1647:
ENSG00000206240, ENSG00000229074, ENSG00000196126, ENSG00000206306, ENSG00000228080 GRCh38: Ensembl release 89: ENSG00000236884, ENSG00000206240, ENSG00000229074, ENSG00000196126, ENSG00000206306, ENSG00000228080
2622:
2292:
2232:
1606:. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 5 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
2592:
2367:
2112:
2382:
52:
2547:
2406:: Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
2187:
2247:
2577:
2562:
2487:
2337:
2427:
2442:
2541:: Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen
2262:
571:
470:
2637:
2616:: Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3--L-alanine) and the Superantigen, SEC3 Variant 3B2
2142:
2157:
1539:. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the
2127:
2172:
1832:
Langton, David J.; Bourke, Stephen C.; Lie, Benedicte A.; Reiff, Gabrielle; Natu, Shonali; Darlay, Rebecca; Burn, John; Echevarria, Carlos (2021-05-04).
393:
1168:
1149:
2472:
2995:
2678:
2457:
2971:
2077:
1702:
1684:
2990:
2517:
557:
2286:: Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4
2226:: CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1
2211:: STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES
1445:
1438:
534:
2361:: Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
2331:: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2
2316:: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the Superantigen SEC3 Variant 3B1
2878:
2687:
2412:
1727:
1671:
1650:
1743:"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis"
2106:: HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE
1667:
456:
431:
1785:"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis"
1646:
2502:
2631:: Mycoplasma arthritidis-derived mitogen complexed with class II MHC molecule HLA-DR1/HA complex in the presence of EDTA
570:
469:
373:
2301:: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3
1586:
have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
1515:. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of
563:
462:
2241:: X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE
2908:
2671:
2964:
2898:
2070:
1235:
381:
2601:: Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
2376:: Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
2873:
2121:: CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN
1548:
1216:
1206:
1202:
1198:
1194:
1190:
2391:: Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II
2903:
1579:
2664:
1571:
2556:: Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule
2196:: CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE
2957:
2256:: CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II
2063:
1516:
445:
360:
1610:
1551:(APC: B lymphocytes, dendritic cells, macrophages), and could be induced in non-professional APCs.
1396:
1392:
1384:
1337:
1333:
1325:
2586:: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
2571:: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
1400:
1536:
405:
1421:
1388:
1358:
1329:
2883:
2043:
2008:
1963:
1923:
1873:
1855:
1814:
1764:
401:
353:
45:
2941:
2496:: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2
2346:: Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1
2033:
1998:
1988:
1955:
1913:
1905:
1863:
1845:
1804:
1796:
1754:
650:
581:
525:
480:
364:, DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, major histocompatibility complex, class II, DR beta 1
2656:
2436:: COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB
2845:
1079:
positive regulation of insulin secretion involved in cellular response to glucose stimulus
625:
1019:
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
2451:: HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation
2003:
1976:
1918:
1893:
1868:
1833:
1809:
1784:
1567:
2271:: CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
856:
851:
846:
841:
2984:
1544:
1540:
828:
2646:: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II
2937:
2739:
1532:
643:
422:
1566:, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
385:
1909:
999:
antigen processing and presentation of exogenous peptide antigen via MHC class II
409:
2893:
2696:
1707:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1689:
National Center for
Biotechnology Information, U.S. National Library of Medicine
726:
1554:
There is evidence it is associated with reduced severity of COVID-19 disease.
542:
439:
389:
2151:: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB
1993:
1859:
1728:"Entrez Gene: HLA-DRB1 major histocompatibility complex, class II, DR beta 1"
1609:
Prevalence of the HLA-DRB1*10:01 allele was greatly increased in people with
1014:
immunoglobulin production involved in immunoglobulin-mediated immune response
1946:
Turesson C, Matteson EL (January 2006). "Genetics of rheumatoid arthritis".
1575:
1113:
786:
664:
609:
596:
508:
495:
397:
2047:
2012:
1967:
1927:
1877:
1818:
1759:
1742:
2166:: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB
1768:
1485:
1480:
2888:
2855:
2850:
2823:
2818:
2813:
2808:
2803:
2791:
2786:
2038:
2021:
1603:
1599:
1595:
1469:
1292:
1288:
1284:
1280:
1276:
1261:
2835:
2774:
2769:
2757:
2752:
1528:
1501:
1247:
1180:
1850:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
2830:
2798:
2781:
2764:
2747:
1977:"Genetics of inflammatory bowel disease: the role of the HLA complex"
1834:"The influence of HLA genotype on the severity of COVID-19 infection"
1622:
1583:
1512:
1453:
1135:
2925:
1959:
1800:
958:
integral component of lumenal side of endoplasmic reticulum membrane
2136:: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB
1594:
DRB1 is expressed at a level five times higher than its paralogues
2729:
2724:
2719:
2714:
2709:
2704:
2181:: CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB
1547:. Class II molecules are constitutively expressed in professional
1098:
1094:
2933:
1563:
1508:
377:
2660:
2481:: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)
2059:
1582:
specifying the peptide binding specificities. Hundreds of DRB1
28:
2055:
1562:
The beta chain is approximately 26-28 kDa. It is encoded by 6
1543:
by presenting peptides derived from extracellular proteins to
1024:
humoral immune response mediated by circulating immunoglobulin
1578:
tail. Within the DR molecule the beta chain contains all the
2022:"HLA-DR15 haplotype and multiple sclerosis: a HuGE review"
1034:
peptide antigen assembly with MHC class II protein complex
2466:: HLA-DR1 complexed with a 13 residue HIV capsid peptide
1498:
HLA class II histocompatibility antigen, DRB1 beta chain
633:
2945:
1741:
Gregersen PK, Silver J, Winchester RJ (November 1987).
798:
2526:: Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a
1894:"Clinical manifestations of the anti-IgLON5 disease"
2866:
2738:
2695:
2020:Schmidt H, Williamson D, Ashley-Koch A (May 2007).
1414:
1377:
1351:
1318:
1722:
1720:
1718:
1716:
1663:
1661:
1659:
1642:
1640:
1638:
1511:. DRB1 encodes the most prevalent beta subunit of
1049:negative regulation of interferon-gamma production
580:
479:
16:Protein-coding gene in the species Homo sapiens
1668:GRCm38: Ensembl release 89: ENSMUSG00000060586
2965:
2672:
2071:
8:
1975:Ahmad T, Marshall SE, Jewell D (June 2006).
1069:negative regulation of T cell proliferation
1054:inflammatory response to antigenic stimulus
1009:interferon-gamma-mediated signaling pathway
2972:
2958:
2679:
2665:
2657:
2421:: Crystal structure of the MAM-MHC complex
2078:
2064:
2056:
1271:
1185:
1109:
883:clathrin-coated endocytic vesicle membrane
824:
621:
520:
417:
63:
2037:
2002:
1992:
1917:
1867:
1849:
1808:
1758:
2093:
1634:
1064:regulation of interleukin-4 production
948:ER to Golgi transport vesicle membrane
18:
585:
546:
541:
484:
443:
438:
7:
2922:
2920:
1531:encoded by this gene belongs to the
857:MHC class II protein complex binding
994:antigen processing and presentation
2944:. You can help Knowledge (XXG) by
2511:: TCR/HLA-DR2b/MBP-peptide complex
1411:
1374:
1348:
1315:
1252:
1226:
1159:
1140:
803:
721:
659:
638:
14:
1981:World Journal of Gastroenterology
1504:that in humans is encoded by the
1039:T cell receptor signaling pathway
2924:
2879:Minor histocompatibility antigen
2688:Major histocompatibility complex
2636:
2621:
2606:
2591:
2576:
2561:
2546:
2531:
2516:
2501:
2486:
2471:
2456:
2441:
2426:
2411:
2396:
2381:
2366:
2351:
2336:
2321:
2306:
2291:
2276:
2261:
2246:
2231:
2216:
2201:
2186:
2171:
2156:
2141:
2126:
2111:
2096:
2026:American Journal of Epidemiology
1558:Gene structure and polymorphisms
968:external side of plasma membrane
569:
562:
556:
533:
468:
461:
455:
430:
27:
1074:T-helper 1 type immune response
1574:domain and exon 5 encodes the
903:endoplasmic reticulum membrane
873:integral component of membrane
847:MHC class II receptor activity
787:More reference expression data
1:
2996:Human chromosome 6 gene stubs
554:
453:
1910:10.1212/WNL.0000000000003887
933:MHC class II protein complex
898:trans-Golgi network membrane
2991:Genes on human chromosome 6
3012:
2919:
2909:Cluster of differentiation
928:transport vesicle membrane
878:endocytic vesicle membrane
2899:Human blood group systems
2091:
1703:"Mouse PubMed Reference:"
1685:"Human PubMed Reference:"
1484:
1479:
1475:
1468:
1452:
1433:
1418:
1381:
1370:
1355:
1322:
1311:
1300:
1274:
1259:
1255:
1246:
1233:
1229:
1214:
1188:
1179:
1166:
1162:
1147:
1143:
1134:
1119:
1112:
1108:
1092:
827:
823:
811:
806:
797:
784:
733:
724:
671:
662:
632:
624:
620:
603:
590:
553:
532:
523:
519:
502:
489:
452:
429:
420:
416:
371:
368:
358:
351:
346:
71:
66:
49:
44:
39:
35:
26:
21:
1994:10.3748/wjg.v12.i23.3628
1747:Arthritis and Rheumatism
1549:antigen-presenting cells
1446:Chr 17: 34.52 – 34.54 Mb
1044:adaptive immune response
2904:Cell adhesion molecules
2874:Human leukocyte antigen
1948:Mayo Clinic Proceedings
1439:Chr 6: 32.58 – 32.59 Mb
1059:protein tetramerization
842:peptide antigen binding
695:upper lobe of left lung
1760:10.1002/art.1780301102
913:late endosome membrane
737:mesenteric lymph nodes
587:17 B1|17 17.98 cM
1570:, exon 4 encodes the
1004:immune system process
978:extracellular exosome
943:endoplasmic reticulum
711:right coronary artery
548:Chromosome 17 (mouse)
1517:rheumatoid arthritis
1084:T cell costimulation
765:white adipose tissue
446:Chromosome 6 (human)
410:HLA-DRB1 - orthologs
67:List of PDB id codes
40:Available structures
1611:anti-IgLON5 disease
749:submandibular gland
2932:This article on a
2039:10.1093/aje/kwk118
1236:ENSMUSG00000060586
987:Biological process
938:lysosomal membrane
866:Cellular component
835:Molecular function
773:tibiofemoral joint
2953:
2952:
2917:
2916:
2884:Blood transfusion
2654:
2653:
1904:(18): 1736–1743.
1851:10.1111/tan.14284
1495:
1494:
1491:
1490:
1464:
1463:
1429:
1428:
1408:
1407:
1366:
1365:
1345:
1344:
1307:
1306:
1268:
1267:
1242:
1241:
1223:
1222:
1175:
1174:
1156:
1155:
1104:
1103:
963:endosome membrane
819:
818:
815:
814:
793:
792:
780:
779:
718:
717:
616:
615:
515:
514:
342:
341:
338:
337:
50:Ortholog search:
3003:
2974:
2967:
2960:
2928:
2921:
2681:
2674:
2667:
2658:
2640:
2625:
2610:
2595:
2580:
2565:
2550:
2535:
2520:
2505:
2490:
2475:
2460:
2445:
2430:
2415:
2400:
2385:
2370:
2355:
2340:
2325:
2310:
2295:
2280:
2265:
2250:
2235:
2220:
2205:
2190:
2175:
2160:
2145:
2130:
2115:
2100:
2080:
2073:
2066:
2057:
2051:
2041:
2032:(10): 1097–109.
2016:
2006:
1996:
1971:
1932:
1931:
1921:
1888:
1882:
1881:
1871:
1853:
1829:
1823:
1822:
1812:
1779:
1773:
1772:
1762:
1738:
1732:
1731:
1724:
1711:
1710:
1699:
1693:
1692:
1681:
1675:
1665:
1654:
1644:
1477:
1476:
1448:
1441:
1424:
1412:
1403:
1375:
1371:RefSeq (protein)
1361:
1349:
1340:
1316:
1296:
1272:
1253:
1227:
1210:
1186:
1160:
1141:
1110:
825:
804:
789:
729:
727:Top expressed in
722:
667:
665:Top expressed in
660:
639:
622:
612:
599:
588:
573:
566:
560:
549:
537:
521:
511:
498:
487:
472:
465:
459:
448:
434:
418:
412:
363:
356:
333:
64:
58:
37:
36:
31:
19:
3011:
3010:
3006:
3005:
3004:
3002:
3001:
3000:
2981:
2980:
2979:
2978:
2918:
2913:
2862:
2734:
2691:
2685:
2655:
2650:
2647:
2641:
2632:
2626:
2617:
2611:
2602:
2596:
2587:
2581:
2572:
2566:
2557:
2551:
2542:
2536:
2527:
2521:
2512:
2506:
2497:
2491:
2482:
2476:
2467:
2461:
2452:
2446:
2437:
2431:
2422:
2416:
2407:
2401:
2392:
2386:
2377:
2371:
2362:
2356:
2347:
2341:
2332:
2326:
2317:
2311:
2302:
2296:
2287:
2281:
2272:
2266:
2257:
2251:
2242:
2236:
2227:
2221:
2212:
2206:
2197:
2191:
2182:
2176:
2167:
2161:
2152:
2146:
2137:
2131:
2122:
2116:
2107:
2101:
2087:
2084:
2054:
2019:
1987:(23): 3628–35.
1974:
1960:10.4065/81.1.94
1945:
1941:
1939:Further reading
1936:
1935:
1890:
1889:
1885:
1831:
1830:
1826:
1801:10.1038/ng.1076
1789:Nature Genetics
1781:
1780:
1776:
1753:(11): 1205–13.
1740:
1739:
1735:
1726:
1725:
1714:
1701:
1700:
1696:
1683:
1682:
1678:
1666:
1657:
1645:
1636:
1631:
1619:
1592:
1590:Gene expression
1560:
1525:
1486:View/Edit Mouse
1481:View/Edit Human
1444:
1437:
1434:Location (UCSC)
1420:
1399:
1395:
1391:
1387:
1383:
1357:
1336:
1332:
1328:
1324:
1295:
1291:
1287:
1283:
1279:
1275:
1217:ENSG00000228080
1209:
1207:ENSG00000206306
1205:
1203:ENSG00000196126
1201:
1199:ENSG00000229074
1197:
1195:ENSG00000206240
1193:
1191:ENSG00000236884
1189:
1088:
1029:immune response
982:
923:plasma membrane
893:Golgi apparatus
861:
852:protein binding
785:
776:
771:
769:right lung lobe
767:
763:
759:
755:
751:
747:
743:
739:
725:
714:
709:
705:
701:
697:
693:
689:
685:
681:
677:
663:
607:
594:
586:
576:
575:
574:
567:
547:
524:Gene location (
506:
493:
485:
475:
474:
473:
466:
444:
421:Gene location (
372:
359:
352:
73:
51:
17:
12:
11:
5:
3009:
3007:
2999:
2998:
2993:
2983:
2982:
2977:
2976:
2969:
2962:
2954:
2951:
2950:
2929:
2915:
2914:
2912:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2870:
2868:
2864:
2863:
2861:
2860:
2859:
2858:
2853:
2848:
2843:
2838:
2828:
2827:
2826:
2821:
2816:
2811:
2806:
2796:
2795:
2794:
2789:
2779:
2778:
2777:
2772:
2762:
2761:
2760:
2755:
2744:
2742:
2736:
2735:
2733:
2732:
2727:
2722:
2717:
2712:
2707:
2701:
2699:
2693:
2692:
2686:
2684:
2683:
2676:
2669:
2661:
2652:
2651:
2649:
2648:
2642:
2635:
2633:
2627:
2620:
2618:
2612:
2605:
2603:
2597:
2590:
2588:
2582:
2575:
2573:
2567:
2560:
2558:
2552:
2545:
2543:
2537:
2530:
2528:
2522:
2515:
2513:
2507:
2500:
2498:
2492:
2485:
2483:
2477:
2470:
2468:
2462:
2455:
2453:
2447:
2440:
2438:
2432:
2425:
2423:
2417:
2410:
2408:
2402:
2395:
2393:
2387:
2380:
2378:
2372:
2365:
2363:
2357:
2350:
2348:
2342:
2335:
2333:
2327:
2320:
2318:
2312:
2305:
2303:
2297:
2290:
2288:
2282:
2275:
2273:
2267:
2260:
2258:
2252:
2245:
2243:
2237:
2230:
2228:
2222:
2215:
2213:
2207:
2200:
2198:
2192:
2185:
2183:
2177:
2170:
2168:
2162:
2155:
2153:
2147:
2140:
2138:
2132:
2125:
2123:
2117:
2110:
2108:
2102:
2095:
2092:
2089:
2088:
2085:
2083:
2082:
2075:
2068:
2060:
2053:
2052:
2017:
1972:
1942:
1940:
1937:
1934:
1933:
1883:
1824:
1774:
1733:
1712:
1694:
1676:
1655:
1633:
1632:
1630:
1627:
1626:
1625:
1618:
1615:
1591:
1588:
1559:
1556:
1545:T helper cells
1524:
1521:
1493:
1492:
1489:
1488:
1483:
1473:
1472:
1466:
1465:
1462:
1461:
1459:
1457:
1450:
1449:
1442:
1435:
1431:
1430:
1427:
1426:
1416:
1415:
1409:
1406:
1405:
1379:
1378:
1372:
1368:
1367:
1364:
1363:
1353:
1352:
1346:
1343:
1342:
1320:
1319:
1313:
1309:
1308:
1305:
1304:
1298:
1297:
1269:
1266:
1265:
1257:
1256:
1250:
1244:
1243:
1240:
1239:
1231:
1230:
1224:
1221:
1220:
1212:
1211:
1183:
1177:
1176:
1173:
1172:
1164:
1163:
1157:
1154:
1153:
1145:
1144:
1138:
1132:
1131:
1126:
1121:
1117:
1116:
1106:
1105:
1102:
1101:
1090:
1089:
1087:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
990:
988:
984:
983:
981:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
918:Golgi membrane
915:
910:
905:
900:
895:
890:
885:
880:
875:
869:
867:
863:
862:
860:
859:
854:
849:
844:
838:
836:
832:
831:
821:
820:
817:
816:
813:
812:
809:
808:
801:
795:
794:
791:
790:
782:
781:
778:
777:
775:
774:
770:
766:
762:
758:
754:
750:
746:
742:
738:
734:
731:
730:
719:
716:
715:
713:
712:
708:
704:
700:
696:
692:
688:
684:
680:
676:
672:
669:
668:
656:
655:
647:
636:
630:
629:
626:RNA expression
618:
617:
614:
613:
605:
601:
600:
592:
589:
584:
578:
577:
568:
561:
555:
551:
550:
545:
539:
538:
530:
529:
517:
516:
513:
512:
504:
500:
499:
491:
488:
483:
477:
476:
467:
460:
454:
450:
449:
442:
436:
435:
427:
426:
414:
413:
370:
366:
365:
357:
349:
348:
344:
343:
340:
339:
336:
335:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3008:
2997:
2994:
2992:
2989:
2988:
2986:
2975:
2970:
2968:
2963:
2961:
2956:
2955:
2949:
2947:
2943:
2939:
2935:
2930:
2927:
2923:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2871:
2869:
2865:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2833:
2832:
2829:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2801:
2800:
2797:
2793:
2790:
2788:
2785:
2784:
2783:
2780:
2776:
2773:
2771:
2768:
2767:
2766:
2763:
2759:
2756:
2754:
2751:
2750:
2749:
2746:
2745:
2743:
2741:
2737:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2702:
2700:
2698:
2694:
2689:
2682:
2677:
2675:
2670:
2668:
2663:
2662:
2659:
2645:
2639:
2634:
2630:
2624:
2619:
2615:
2609:
2604:
2600:
2594:
2589:
2585:
2579:
2574:
2570:
2564:
2559:
2555:
2549:
2544:
2540:
2534:
2529:
2525:
2519:
2514:
2510:
2504:
2499:
2495:
2489:
2484:
2480:
2474:
2469:
2465:
2459:
2454:
2450:
2444:
2439:
2435:
2429:
2424:
2420:
2414:
2409:
2405:
2399:
2394:
2390:
2384:
2379:
2375:
2369:
2364:
2360:
2354:
2349:
2345:
2339:
2334:
2330:
2324:
2319:
2315:
2309:
2304:
2300:
2294:
2289:
2285:
2279:
2274:
2270:
2264:
2259:
2255:
2249:
2244:
2240:
2234:
2229:
2225:
2219:
2214:
2210:
2204:
2199:
2195:
2189:
2184:
2180:
2174:
2169:
2165:
2159:
2154:
2150:
2144:
2139:
2135:
2129:
2124:
2120:
2114:
2109:
2105:
2099:
2094:
2090:
2081:
2076:
2074:
2069:
2067:
2062:
2061:
2058:
2049:
2045:
2040:
2035:
2031:
2027:
2023:
2018:
2014:
2010:
2005:
2000:
1995:
1990:
1986:
1982:
1978:
1973:
1969:
1965:
1961:
1957:
1954:(1): 94–101.
1953:
1949:
1944:
1943:
1938:
1929:
1925:
1920:
1915:
1911:
1907:
1903:
1899:
1895:
1887:
1884:
1879:
1875:
1870:
1865:
1861:
1857:
1852:
1847:
1843:
1839:
1835:
1828:
1825:
1820:
1816:
1811:
1806:
1802:
1798:
1794:
1790:
1786:
1778:
1775:
1770:
1766:
1761:
1756:
1752:
1748:
1744:
1737:
1734:
1729:
1723:
1721:
1719:
1717:
1713:
1708:
1704:
1698:
1695:
1690:
1686:
1680:
1677:
1673:
1669:
1664:
1662:
1660:
1656:
1652:
1648:
1643:
1641:
1639:
1635:
1628:
1624:
1621:
1620:
1616:
1614:
1612:
1607:
1605:
1601:
1597:
1589:
1587:
1585:
1581:
1580:polymorphisms
1577:
1573:
1572:transmembrane
1569:
1565:
1557:
1555:
1552:
1550:
1546:
1542:
1541:immune system
1538:
1534:
1530:
1522:
1520:
1518:
1514:
1510:
1507:
1503:
1499:
1487:
1482:
1478:
1474:
1471:
1467:
1460:
1458:
1455:
1451:
1447:
1443:
1440:
1436:
1432:
1425:
1423:
1417:
1413:
1410:
1404:
1402:
1398:
1394:
1390:
1386:
1380:
1376:
1373:
1369:
1362:
1360:
1354:
1350:
1347:
1341:
1339:
1335:
1331:
1327:
1321:
1317:
1314:
1312:RefSeq (mRNA)
1310:
1303:
1299:
1294:
1290:
1286:
1282:
1278:
1273:
1270:
1264:
1263:
1258:
1254:
1251:
1249:
1245:
1238:
1237:
1232:
1228:
1225:
1219:
1218:
1213:
1208:
1204:
1200:
1196:
1192:
1187:
1184:
1182:
1178:
1171:
1170:
1165:
1161:
1158:
1152:
1151:
1146:
1142:
1139:
1137:
1133:
1130:
1127:
1125:
1122:
1118:
1115:
1111:
1107:
1100:
1096:
1091:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
991:
989:
986:
985:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
870:
868:
865:
864:
858:
855:
853:
850:
848:
845:
843:
840:
839:
837:
834:
833:
830:
829:Gene ontology
826:
822:
810:
805:
802:
800:
796:
788:
783:
772:
768:
764:
760:
756:
752:
748:
744:
740:
736:
735:
732:
728:
723:
720:
710:
706:
702:
698:
694:
690:
686:
682:
678:
674:
673:
670:
666:
661:
658:
657:
654:
652:
648:
646:
645:
641:
640:
637:
635:
631:
627:
623:
619:
611:
606:
602:
598:
593:
583:
579:
572:
565:
559:
552:
544:
540:
536:
531:
527:
522:
518:
510:
505:
501:
497:
492:
482:
478:
471:
464:
458:
451:
447:
441:
437:
433:
428:
424:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
367:
362:
355:
350:
345:
334:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2946:expanding it
2938:chromosome 6
2931:
2840:
2740:MHC class II
2643:
2628:
2613:
2598:
2583:
2568:
2553:
2538:
2523:
2508:
2493:
2478:
2463:
2448:
2433:
2418:
2403:
2388:
2373:
2358:
2343:
2328:
2313:
2298:
2283:
2268:
2253:
2238:
2223:
2208:
2193:
2178:
2163:
2148:
2133:
2118:
2103:
2029:
2025:
1984:
1980:
1951:
1947:
1901:
1897:
1886:
1844:(1): 14–22.
1841:
1837:
1827:
1795:(3): 291–6.
1792:
1788:
1777:
1750:
1746:
1736:
1706:
1697:
1688:
1679:
1608:
1593:
1561:
1553:
1533:HLA class II
1526:
1505:
1497:
1496:
1419:
1397:NP_001346123
1393:NP_001346122
1385:NP_001230894
1382:
1356:
1338:NM_001359194
1334:NM_001359193
1326:NM_001243965
1323:
1301:
1260:
1234:
1215:
1167:
1148:
1128:
1123:
973:cell surface
753:carotid body
649:
642:
369:External IDs
72:
2894:Calgranulin
2697:MHC class I
2086:PDB gallery
1576:cytoplasmic
1535:beta chain
1401:NP_002115.2
703:gallbladder
679:granulocyte
608:34,535,648
595:34,524,841
507:32,589,848
494:32,577,902
347:Identifiers
2985:Categories
1674:, May 2017
1653:, May 2017
1629:References
1537:paralogues
757:right lung
687:lymph node
683:right lung
653:(ortholog)
390:HomoloGene
2936:on human
1898:Neurology
1860:2059-2302
1422:NP_034512
1389:NP_002115
1359:NM_010382
1330:NM_002124
1114:Orthologs
398:GeneCards
2889:Arrestin
2048:17329717
2013:16773677
1968:16438485
1928:28381508
1878:33896121
1819:22286218
1670:–
1649:–
1617:See also
1523:Function
1506:HLA-DRB1
1470:Wikidata
1093:Sources:
953:lysosome
908:membrane
888:endosome
707:duodenum
699:monocyte
675:appendix
402:HLA-DRB1
361:HLA-DRB1
22:HLA-DRB1
2690:classes
2004:4087453
1919:5409845
1869:8251294
1810:3288335
1769:2446635
1672:Ensembl
1651:Ensembl
1584:alleles
1568:domains
1529:protein
1502:protein
1248:UniProt
1181:Ensembl
1120:Species
1099:QuickGO
628:pattern
486:6p21.32
354:Aliases
2831:HLA-DR
2799:HLA-DQ
2782:HLA-DP
2765:HLA-DO
2748:HLA-DM
2046:
2011:
2001:
1966:
1926:
1916:
1876:
1866:
1858:
1817:
1807:
1767:
1623:HLA-DR
1513:HLA-DR
1456:search
1454:PubMed
1293:O78196
1289:P18469
1285:P18468
1281:P04230
1277:P04231
1262:P01911
1136:Entrez
799:BioGPS
745:thymus
741:spleen
691:spleen
394:136635
378:142857
2940:is a
2867:Other
2730:HLA-G
2725:HLA-F
2720:HLA-E
2715:HLA-C
2710:HLA-B
2705:HLA-A
1564:exons
1500:is a
1169:14969
1129:Mouse
1124:Human
1095:Amigo
651:Mouse
644:Human
591:Start
526:Mouse
490:Start
423:Human
386:95901
2942:stub
2934:gene
2644:2seb
2629:2oje
2614:2ipk
2599:2icw
2584:2ian
2569:2iam
2554:2g9h
2539:2fse
2524:1zgl
2509:1ymm
2494:1t5x
2479:1t5w
2464:1sjh
2449:1sje
2434:1seb
2419:1r5i
2404:1pyw
2389:1lo5
2374:1klu
2359:1klg
2344:1kg0
2329:1jwu
2314:1jws
2299:1jwm
2284:1j8h
2269:1hxy
2254:1hqr
2239:1h15
2224:1fyt
2209:1fv1
2194:1dlh
2179:1d6e
2164:1d5z
2149:1d5x
2134:1d5m
2119:1bx2
2104:1aqd
2044:PMID
2009:PMID
1964:PMID
1924:PMID
1874:PMID
1856:ISSN
1815:PMID
1765:PMID
1604:DRB5
1602:and
1600:DRB4
1596:DRB3
1527:The
1509:gene
1150:3123
634:Bgee
582:Band
543:Chr.
481:Band
440:Chr.
374:OMIM
331:4Y1A
327:4Y19
323:4MDJ
319:4MDI
315:4MD5
311:4MD4
307:4MD0
303:4MCZ
299:4MCY
295:4IS6
291:3T0E
287:3O6F
283:2SEB
279:1J8H
275:1D6E
271:1D5Z
267:1D5X
263:1D5M
261:,%%s
259:4X5X
255:4X5W
251:4OV5
247:4I5B
243:4GBX
239:4FQX
235:4E41
231:4C56
227:4AH2
223:4AEN
219:3S5L
215:3S4S
211:3QXD
207:3QXA
203:3PGD
199:3PGC
195:3PDO
191:3L6F
187:2XN9
183:2OJE
179:2IPK
175:2ICW
171:2IAN
167:2IAM
163:2G9H
159:2FSE
155:1T5X
151:1T5W
147:1SJH
143:1SEB
139:1R5I
135:1PYW
131:1LO5
127:1KLU
123:1KLG
119:1KG0
115:1JWU
111:1JWS
107:1JWM
103:1HXY
99:1FYT
95:1DLH
91:1AQD
89:,%%s
87:2WBJ
83:1YMM
79:1BX2
75:1A6A
56:RCSB
53:PDBe
2034:doi
2030:165
1999:PMC
1989:doi
1956:doi
1914:PMC
1906:doi
1864:PMC
1846:doi
1838:HLA
1805:PMC
1797:doi
1755:doi
1519:.
1302:n/a
807:n/a
761:lip
604:End
503:End
406:OMA
382:MGI
46:PDB
2987::
2856:β5
2851:β4
2846:β3
2841:β1
2824:β3
2819:β2
2814:β1
2809:α2
2804:α1
2792:β1
2787:α1
2042:.
2028:.
2024:.
2007:.
1997:.
1985:12
1983:.
1979:.
1962:.
1952:81
1950:.
1922:.
1912:.
1902:88
1900:.
1896:.
1872:.
1862:.
1854:.
1842:98
1840:.
1836:.
1813:.
1803:.
1793:44
1791:.
1787:.
1763:.
1751:30
1749:.
1745:.
1715:^
1705:.
1687:.
1658:^
1637:^
1613:.
1598:,
1097:/
610:bp
597:bp
509:bp
496:bp
404:;
400::
396:;
392::
388:;
384::
380:;
376::
329:,
325:,
321:,
317:,
313:,
309:,
305:,
301:,
297:,
293:,
289:,
285:,
281:,
277:,
273:,
269:,
265:,
257:,
253:,
249:,
245:,
241:,
237:,
233:,
229:,
225:,
221:,
217:,
213:,
209:,
205:,
201:,
197:,
193:,
189:,
185:,
181:,
177:,
173:,
169:,
165:,
161:,
157:,
153:,
149:,
145:,
141:,
137:,
133:,
129:,
125:,
121:,
117:,
113:,
109:,
105:,
101:,
97:,
93:,
85:,
81:,
77:,
2973:e
2966:t
2959:v
2948:.
2836:α
2775:β
2770:α
2758:β
2753:α
2680:e
2673:t
2666:v
2079:e
2072:t
2065:v
2050:.
2036::
2015:.
1991::
1970:.
1958::
1930:.
1908::
1880:.
1848::
1821:.
1799::
1771:.
1757::
1730:.
1709:.
1691:.
528:)
425:)
408::
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