336:
313:
210:
235:
594:
587:
1986:
1971:
1956:
601:
2001:
342:
241:
31:
1783:
Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C (May 2018). "Peptide-specific recognition
57:
1362:
ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 GRCh38: Ensembl release 89: ENSG00000204592, ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904,
1494:
Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ (Feb 1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C".
1328:
A/B/C. When CD94/NKG2A or CD94/NKG2B is engaged, it produces an inhibitory effect on the cytotoxic activity of the NK cell to prevent cell lysis. However, binding of HLA-E to CD94/NKG2C (see
1638:"Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E"
349:
248:
1252:
molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called
1876:
Jensen PE, Sullivan BA, Reed-Loisel LM, Weber DA (Jun 2004). "Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity".
1313:
1985:
1970:
1955:
1548:"The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9"
949:
171:
930:
1316:(TAP), these peptides bind to a peptide binding groove on the HLA-E molecule. This allows HLA-E to assemble correctly and to be expressed on the
2041:
1418:
1935:
2000:
1400:
2292:
335:
1332:) results in NK cell activation. This interaction has been shown to trigger expansion of NK cell subsets in antiviral responses, where
1178:
1171:
312:
2241:
2050:
1477:
1859:
1842:
1387:
1366:
1383:
1280:, exons 2 and 3 encode the α1 and α2 domains, which both bind the peptide, exon 4 encodes the α3 domain, exon 5 encodes the
234:
209:
1361:
151:
348:
247:
2271:
2034:
1679:"TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide"
341:
240:
2261:
1928:
1300:
of classical MHC class I molecules, namely HLA-A, B, C, G. These peptides are released from the membrane of the
1305:
1020:
159:
54:
2236:
1001:
997:
987:
983:
979:
975:
971:
2266:
1678:
2027:
1301:
1921:
1690:
1597:"Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes"
1504:
1293:
1281:
1269:
223:
138:
1272:). The heavy chain is approximately 45 kDa and anchored in the membrane. The HLA-E gene contains 8
1109:
1901:
1809:
1716:
1577:
1528:
810:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
183:
1135:
1088:
770:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
2246:
1893:
1864:
1801:
1765:
1708:
1659:
1618:
1569:
1520:
1459:
1333:
593:
586:
131:
47:
1885:
1854:
1793:
1755:
1747:
1698:
1649:
1608:
1559:
1512:
1449:
428:
359:
303:
258:
2019:
600:
179:
2208:
1297:
403:
1694:
1508:
1760:
1735:
1277:
1703:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
667:
662:
657:
652:
647:
642:
2286:
1438:"Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene"
1317:
629:
1905:
1720:
1581:
1268:
molecules, HLA-E is a heterodimer consisting of an α heavy chain and a light chain (
163:
2102:
1813:
1532:
421:
200:
1736:"IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion"
1734:
Rölle A, Pollmann J, Ewen EM, Le VT, Halenius A, Hengel H, Cerwenka A (Dec 2014).
865:
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
1613:
1596:
1454:
1437:
187:
2256:
2059:
1889:
1423:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1405:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1320:. NK cells recognize the HLA-E+peptide complex using the heterodimeric receptor
1265:
1249:
504:
142:, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
1797:
1309:
320:
217:
167:
1841:
Moretta L, Bottino C, Pende D, Mingari MC, Biassoni R, Moretta A (May 2002).
894:
564:
442:
387:
374:
286:
273:
175:
1897:
1868:
1834:, 6th edition, by Thomas J. Kindt, Richard A. Goldsby, and Barbara A. Kuby
1805:
1769:
1663:
1654:
1637:
1622:
1564:
1547:
1784:
of human cytomegalovirus strains controls adaptive natural killer cells".
1712:
1573:
1524:
1463:
1218:
1213:
2251:
2218:
2213:
2203:
2186:
2181:
2176:
2171:
2166:
2154:
2149:
1994:: THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E
1979:: The human non-classical major histocompatibility complex molecule HLA-E
1964:: The human non-classical major histocompatibility complex molecule HLA-E
1202:
1046:
2198:
2137:
2132:
2120:
2115:
1860:
10.1002/1521-4141(200205)32:5<1205::AID-IMMU1205>3.0.CO;2-Y
1238:
1032:
961:
1636:
Bland FA, Lemberg MK, McMichael AJ, Martoglio B, Braud VM (Sep 2003).
790:
antigen processing and presentation of peptide antigen via MHC class I
108:
104:
100:
96:
92:
88:
84:
80:
76:
2193:
2161:
2144:
2127:
2110:
1751:
1296:(NK cells). HLA-E binds a restricted subset of peptides derived from
1186:
916:
1595:
Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B (Dec 2001).
860:
positive regulation of CD8-positive, alpha-beta T cell proliferation
734:
integral component of lumenal side of endoplasmic reticulum membrane
2092:
2087:
2077:
2072:
2067:
1843:"Human natural killer cells: their origin, receptors and function"
1516:
1329:
1273:
1253:
1478:"Entrez Gene: HLA-E major histocompatibility complex, class I, E"
879:
875:
1337:
1325:
1321:
1245:
155:
30:
2023:
1917:
1436:
Mizuno S, Trapani JA, Koller BH, Dupont B, Yang SY (Jun 1988).
609:
1913:
1231:
HLA class I histocompatibility antigen, alpha chain E (HLA-E)
840:
positive regulation of natural killer cell mediated immunity
1292:
HLA-E has a very specialized role in cell recognition by
815:
protection from natural killer cell mediated cytotoxicity
411:
1677:
Braud VM, Allan DS, Wilson D, McMichael AJ (Jan 1998).
850:
positive regulation of tumor necrosis factor production
2009:: Structure of the HLA-E-VMAPRTLIL/KK50.4 TCR complex
576:
2229:
2101:
2058:
1336:that express CD94/NKG2C can specifically recognise
1149:
1128:
1102:
1081:
835:
regulation of natural killer cell mediated immunity
795:
positive regulation of T cell mediated cytotoxicity
1379:
1377:
1375:
1357:
1355:
1353:
1284:, and exons 6 and 7 encode the cytoplasmic tail.
358:
257:
820:positive regulation of interleukin-13 production
658:natural killer cell lectin-like receptor binding
805:positive regulation of interleukin-4 production
16:Protein-coding gene in the species Homo sapiens
1384:GRCm38: Ensembl release 89: ENSMUSG00000073405
1314:transporter associated with antigen processing
2035:
1929:
1489:
1487:
8:
1546:Braud V, Jones EY, McMichael A (May 1997).
780:interferon-gamma-mediated signaling pathway
2042:
2028:
2020:
1936:
1922:
1914:
1312:. Upon transport into the ER lumen by the
966:
890:
775:CD8-positive, alpha-beta T cell activation
625:
399:
298:
195:
65:
1858:
1759:
1702:
1653:
1612:
1563:
1453:
1951:
1349:
800:positive regulation of TRAIL production
729:ER to Golgi transport vesicle membrane
20:
1740:The Journal of Clinical Investigation
1248:. The human HLA-E is a non-classical
363:
324:
319:
262:
221:
216:
7:
1836:W. H. Freeman and Company, New York
1642:The Journal of Biological Chemistry
825:type I interferon signaling pathway
760:antigen processing and presentation
1146:
1125:
1099:
1078:
1056:
1037:
1011:
940:
921:
581:
499:
437:
416:
14:
1241:that in humans is encoded by the
2242:Minor histocompatibility antigen
2051:Major histocompatibility complex
1999:
1984:
1969:
1954:
599:
592:
585:
347:
340:
334:
311:
246:
239:
233:
208:
29:
1847:European Journal of Immunology
1552:European Journal of Immunology
1256:, officially known as H2-T23.
684:integral component of membrane
610:More reference expression data
565:More reference expression data
1:
1704:10.1016/S0960-9822(98)70014-4
1308:and trimmed by the cytosolic
845:regulation of immune response
332:
231:
1614:10.4049/jimmunol.167.11.6441
1455:10.4049/jimmunol.140.11.4024
704:MHC class Ib protein complex
643:beta-2-microglobulin binding
2293:Genes on human chromosome 6
1340:-derived peptide antigens.
744:recycling endosome membrane
724:MHC class I protein complex
689:phagocytic vesicle membrane
648:MHC class I protein binding
481:subcutaneous adipose tissue
2309:
2272:Cluster of differentiation
653:signaling receptor binding
2262:Human blood group systems
1949:
1798:10.1038/s41590-018-0082-6
1419:"Mouse PubMed Reference:"
1401:"Human PubMed Reference:"
1217:
1212:
1208:
1201:
1185:
1166:
1153:
1132:
1121:
1106:
1085:
1074:
1063:
1059:
1044:
1040:
1031:
1018:
1014:
995:
969:
960:
947:
943:
928:
924:
915:
900:
893:
889:
873:
628:
624:
607:
584:
575:
562:
511:
502:
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
73:
68:
51:
46:
41:
37:
28:
23:
1306:signal peptide peptidase
1179:Chr 17: 36.42 – 36.42 Mb
765:adaptive immune response
2267:Cell adhesion molecules
2237:Human leukocyte antigen
1276:. Exon one encodes the
1172:Chr 6: 30.49 – 30.49 Mb
694:early endosome membrane
668:T cell receptor binding
663:peptide antigen binding
465:upper lobe of left lung
1655:10.1074/jbc.M305593200
1565:10.1002/eji.1830270517
855:innate immune response
527:mesenteric lymph nodes
52:Human UniProt search:
1890:10.1385/IR:29:1-3:081
1601:Journal of Immunology
1442:Journal of Immunology
1302:endoplasmic reticulum
1235:MHC class I antigen E
785:immune system process
739:extracellular exosome
326:Chromosome 17 (mouse)
1878:Immunologic Research
1294:natural killer cells
1282:transmembrane domain
224:Chromosome 6 (human)
69:List of PDB id codes
42:Available structures
1695:1998CBio....8....1B
1509:1998Natur.391..795B
1021:ENSMUSG00000073405
753:Biological process
677:Cellular component
636:Molecular function
2280:
2279:
2247:Blood transfusion
2017:
2016:
1786:Nature Immunology
1334:adaptive NK cells
1270:β-2 microglobulin
1228:
1227:
1224:
1223:
1197:
1196:
1162:
1161:
1143:
1142:
1117:
1116:
1096:
1095:
1070:
1069:
1053:
1052:
1027:
1026:
1008:
1007:
956:
955:
937:
936:
885:
884:
620:
619:
616:
615:
571:
570:
558:
557:
519:intestinal villus
496:
495:
394:
393:
293:
292:
188:HLA-E - orthologs
120:
119:
116:
115:
2300:
2044:
2037:
2030:
2021:
2003:
1988:
1973:
1958:
1938:
1931:
1924:
1915:
1909:
1872:
1862:
1818:
1817:
1780:
1774:
1773:
1763:
1752:10.1172/JCI77440
1731:
1725:
1724:
1706:
1674:
1668:
1667:
1657:
1648:(36): 33747–52.
1633:
1627:
1626:
1616:
1592:
1586:
1585:
1567:
1543:
1537:
1536:
1491:
1482:
1481:
1474:
1468:
1467:
1457:
1433:
1427:
1426:
1415:
1409:
1408:
1397:
1391:
1381:
1370:
1359:
1210:
1209:
1181:
1174:
1157:
1147:
1138:
1126:
1122:RefSeq (protein)
1112:
1100:
1091:
1079:
1057:
1038:
1012:
991:
967:
941:
922:
891:
626:
612:
603:
596:
589:
582:
567:
507:
505:Top expressed in
500:
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
141:
134:
111:
66:
60:
39:
38:
33:
21:
2308:
2307:
2303:
2302:
2301:
2299:
2298:
2297:
2283:
2282:
2281:
2276:
2225:
2097:
2054:
2048:
2018:
2013:
2010:
2004:
1995:
1989:
1980:
1974:
1965:
1959:
1945:
1942:
1912:
1875:
1840:
1832:Kuby Immunology
1827:
1825:Further reading
1822:
1821:
1782:
1781:
1777:
1746:(12): 5305–16.
1733:
1732:
1728:
1683:Current Biology
1676:
1675:
1671:
1635:
1634:
1630:
1594:
1593:
1589:
1545:
1544:
1540:
1503:(6669): 795–9.
1493:
1492:
1485:
1476:
1475:
1471:
1448:(11): 4024–30.
1435:
1434:
1430:
1417:
1416:
1412:
1399:
1398:
1394:
1382:
1373:
1363:ENSG00000229252
1360:
1351:
1346:
1298:signal peptides
1290:
1262:
1219:View/Edit Mouse
1214:View/Edit Human
1177:
1170:
1167:Location (UCSC)
1155:
1134:
1108:
1087:
1002:ENSG00000229252
1000:
998:ENSG00000233904
990:
988:ENSG00000206493
986:
984:ENSG00000230254
982:
980:ENSG00000236632
978:
976:ENSG00000225201
974:
972:ENSG00000204592
970:
869:
830:immune response
748:
714:plasma membrane
672:
608:
598:
597:
591:
590:
563:
554:
549:
545:
541:
537:
533:
529:
525:
521:
517:
503:
492:
487:
483:
479:
475:
471:
467:
463:
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
75:
53:
17:
12:
11:
5:
2306:
2304:
2296:
2295:
2285:
2284:
2278:
2277:
2275:
2274:
2269:
2264:
2259:
2254:
2249:
2244:
2239:
2233:
2231:
2227:
2226:
2224:
2223:
2222:
2221:
2216:
2211:
2206:
2201:
2191:
2190:
2189:
2184:
2179:
2174:
2169:
2159:
2158:
2157:
2152:
2142:
2141:
2140:
2135:
2125:
2124:
2123:
2118:
2107:
2105:
2099:
2098:
2096:
2095:
2090:
2085:
2080:
2075:
2070:
2064:
2062:
2056:
2055:
2049:
2047:
2046:
2039:
2032:
2024:
2015:
2014:
2012:
2011:
2005:
1998:
1996:
1990:
1983:
1981:
1975:
1968:
1966:
1960:
1953:
1950:
1947:
1946:
1943:
1941:
1940:
1933:
1926:
1918:
1911:
1910:
1884:(1–3): 81–92.
1873:
1853:(5): 1205–11.
1838:
1828:
1826:
1823:
1820:
1819:
1792:(5): 453–463.
1775:
1726:
1669:
1628:
1607:(11): 6441–6.
1587:
1538:
1483:
1469:
1428:
1410:
1392:
1371:
1348:
1347:
1345:
1342:
1289:
1286:
1278:signal peptide
1261:
1258:
1233:also known as
1226:
1225:
1222:
1221:
1216:
1206:
1205:
1199:
1198:
1195:
1194:
1192:
1190:
1183:
1182:
1175:
1168:
1164:
1163:
1160:
1159:
1151:
1150:
1144:
1141:
1140:
1130:
1129:
1123:
1119:
1118:
1115:
1114:
1104:
1103:
1097:
1094:
1093:
1083:
1082:
1076:
1072:
1071:
1068:
1067:
1061:
1060:
1054:
1051:
1050:
1042:
1041:
1035:
1029:
1028:
1025:
1024:
1016:
1015:
1009:
1006:
1005:
993:
992:
964:
958:
957:
954:
953:
945:
944:
938:
935:
934:
926:
925:
919:
913:
912:
907:
902:
898:
897:
887:
886:
883:
882:
871:
870:
868:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
756:
754:
750:
749:
747:
746:
741:
736:
731:
726:
721:
716:
711:
709:Golgi membrane
706:
701:
696:
691:
686:
680:
678:
674:
673:
671:
670:
665:
660:
655:
650:
645:
639:
637:
633:
632:
622:
621:
618:
617:
614:
613:
605:
604:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
509:
508:
497:
494:
493:
491:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
148:
144:
143:
135:
127:
126:
122:
121:
118:
117:
114:
113:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2305:
2294:
2291:
2290:
2288:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2234:
2232:
2228:
2220:
2217:
2215:
2212:
2210:
2207:
2205:
2202:
2200:
2197:
2196:
2195:
2192:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2164:
2163:
2160:
2156:
2153:
2151:
2148:
2147:
2146:
2143:
2139:
2136:
2134:
2131:
2130:
2129:
2126:
2122:
2119:
2117:
2114:
2113:
2112:
2109:
2108:
2106:
2104:
2100:
2094:
2091:
2089:
2086:
2084:
2081:
2079:
2076:
2074:
2071:
2069:
2066:
2065:
2063:
2061:
2057:
2052:
2045:
2040:
2038:
2033:
2031:
2026:
2025:
2022:
2008:
2002:
1997:
1993:
1987:
1982:
1978:
1972:
1967:
1963:
1957:
1952:
1948:
1939:
1934:
1932:
1927:
1925:
1920:
1919:
1916:
1907:
1903:
1899:
1895:
1891:
1887:
1883:
1879:
1874:
1870:
1866:
1861:
1856:
1852:
1848:
1844:
1839:
1837:
1833:
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1824:
1815:
1811:
1807:
1803:
1799:
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1791:
1787:
1779:
1776:
1771:
1767:
1762:
1757:
1753:
1749:
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1741:
1737:
1730:
1727:
1722:
1718:
1714:
1710:
1705:
1700:
1696:
1692:
1688:
1684:
1680:
1673:
1670:
1665:
1661:
1656:
1651:
1647:
1643:
1639:
1632:
1629:
1624:
1620:
1615:
1610:
1606:
1602:
1598:
1591:
1588:
1583:
1579:
1575:
1571:
1566:
1561:
1558:(5): 1164–9.
1557:
1553:
1549:
1542:
1539:
1534:
1530:
1526:
1522:
1518:
1517:10.1038/35869
1514:
1510:
1506:
1502:
1498:
1490:
1488:
1484:
1479:
1473:
1470:
1465:
1461:
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1303:
1299:
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1279:
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1259:
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1220:
1215:
1211:
1207:
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1200:
1193:
1191:
1188:
1184:
1180:
1176:
1173:
1169:
1165:
1158:
1152:
1148:
1145:
1139:
1137:
1131:
1127:
1124:
1120:
1113:
1111:
1105:
1101:
1098:
1092:
1090:
1084:
1080:
1077:
1075:RefSeq (mRNA)
1073:
1066:
1062:
1058:
1055:
1049:
1048:
1043:
1039:
1036:
1034:
1030:
1023:
1022:
1017:
1013:
1010:
1004:
1003:
999:
994:
989:
985:
981:
977:
973:
968:
965:
963:
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
911:
908:
906:
903:
899:
896:
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888:
881:
877:
872:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
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773:
771:
768:
766:
763:
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755:
752:
751:
745:
742:
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730:
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715:
712:
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669:
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664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
631:
630:Gene ontology
627:
623:
611:
606:
602:
595:
588:
583:
580:
578:
574:
566:
561:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
365:17|17 B1
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2103:MHC class II
2082:
2006:
1991:
1976:
1961:
1881:
1877:
1850:
1846:
1835:
1831:
1789:
1785:
1778:
1743:
1739:
1729:
1686:
1682:
1672:
1645:
1641:
1631:
1604:
1600:
1590:
1555:
1551:
1541:
1500:
1496:
1472:
1445:
1441:
1431:
1422:
1413:
1404:
1395:
1318:cell surface
1304:(ER) by the
1291:
1263:
1242:
1234:
1230:
1229:
1154:
1133:
1110:NM_001271005
1107:
1086:
1064:
1045:
1019:
996:
948:
929:
909:
904:
719:cell surface
547:right kidney
427:
420:
147:External IDs
74:
18:
2257:Calgranulin
2060:MHC class I
1944:PDB gallery
1689:(1): 1–10.
1266:MHC class I
1264:Like other
1250:MHC class I
535:Paneth cell
523:granulocyte
489:gallbladder
461:granulocyte
386:36,422,550
373:36,420,126
285:30,494,194
272:30,489,509
125:Identifiers
1390:, May 2017
1369:, May 2017
1344:References
1310:proteasome
551:blastocyst
477:lymph node
457:right lung
431:(ortholog)
168:HomoloGene
1260:Structure
1136:NP_005507
1089:NM_005516
895:Orthologs
176:GeneCards
2287:Category
2252:Arrestin
1906:29282633
1898:15181272
1869:11981807
1806:29632329
1770:25384219
1721:14240878
1664:12821659
1623:11714810
1582:36124500
1386:–
1365:–
1288:Function
1203:Wikidata
874:Sources:
699:membrane
531:duodenum
485:appendix
469:monocyte
2053:classes
1814:4718187
1761:4348979
1713:9427624
1691:Bibcode
1574:9174606
1533:4379457
1525:9486650
1505:Bibcode
1464:3131426
1388:Ensembl
1367:Ensembl
1239:protein
1033:UniProt
962:Ensembl
901:Species
880:QuickGO
539:jejunum
406:pattern
164:2442805
132:Aliases
2194:HLA-DR
2162:HLA-DQ
2145:HLA-DP
2128:HLA-DO
2111:HLA-DM
1904:
1896:
1867:
1812:
1804:
1768:
1758:
1719:
1711:
1662:
1621:
1580:
1572:
1531:
1523:
1497:Nature
1462:
1189:search
1187:PubMed
1047:P13747
950:667803
917:Entrez
577:BioGPS
543:zygote
515:thymus
473:spleen
264:6p22.1
172:134018
156:143010
2230:Other
2093:HLA-G
2088:HLA-F
2083:HLA-E
2078:HLA-C
2073:HLA-B
2068:HLA-A
1902:S2CID
1810:S2CID
1717:S2CID
1578:S2CID
1529:S2CID
1330:KLRC2
1274:exons
1254:Qa-1b
1243:HLA-E
1237:is a
910:Mouse
905:Human
876:Amigo
453:blood
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
180:HLA-E
139:HLA-E
24:HLA-E
2007:2esv
1992:1mhe
1977:1ktl
1962:1kpr
1894:PMID
1865:PMID
1802:PMID
1766:PMID
1709:PMID
1660:PMID
1619:PMID
1570:PMID
1521:PMID
1460:PMID
1338:HCMV
1326:NKG2
1322:CD94
1246:gene
931:3133
412:Bgee
360:Band
321:Chr.
259:Band
218:Chr.
152:OMIM
109:3CDG
105:3BZF
101:3BZE
97:3AM8
93:2ESV
89:1MHE
85:1KTL
81:1KPR
77:3CII
58:RCSB
55:PDBe
1886:doi
1855:doi
1794:doi
1756:PMC
1748:doi
1744:124
1699:doi
1650:doi
1646:278
1609:doi
1605:167
1560:doi
1513:doi
1501:391
1450:doi
1446:140
1156:n/a
1065:n/a
382:End
281:End
184:OMA
160:MGI
48:PDB
2289::
2219:β5
2214:β4
2209:β3
2204:β1
2187:β3
2182:β2
2177:β1
2172:α2
2167:α1
2155:β1
2150:α1
1900:.
1892:.
1882:29
1880:.
1863:.
1851:32
1849:.
1845:.
1808:.
1800:.
1790:19
1788:.
1764:.
1754:.
1742:.
1738:.
1715:.
1707:.
1697:.
1685:.
1681:.
1658:.
1644:.
1640:.
1617:.
1603:.
1599:.
1576:.
1568:.
1556:27
1554:.
1550:.
1527:.
1519:.
1511:.
1499:.
1486:^
1458:.
1444:.
1440:.
1421:.
1403:.
1374:^
1352:^
878:/
388:bp
375:bp
287:bp
274:bp
182:;
178::
174:;
170::
166:;
162::
158:;
154::
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
2199:α
2138:β
2133:α
2121:β
2116:α
2043:e
2036:t
2029:v
1937:e
1930:t
1923:v
1908:.
1888::
1871:.
1857::
1816:.
1796::
1772:.
1750::
1723:.
1701::
1693::
1687:8
1666:.
1652::
1625:.
1611::
1584:.
1562::
1535:.
1515::
1507::
1480:.
1466:.
1452::
1425:.
1407:.
1324:/
306:)
203:)
186::
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