Knowledge (XXG)

HMHA1

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301: 278: 175: 200: 559: 552: 307: 206: 1776: 50: 1472:"Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation" 1301:
van Lochem E, van der Keur M, Mommaas AM, et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells".
1638:
Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation".
1369:
Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene".
1243:"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain" 1340:
Aróstegui JI, Gallardo D, Rodríguez-Luaces M, et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)".
1398:
Gillespie G, Mutis T, Schrama E, et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand".
314: 213: 1566:
Wilke M, Dolstra H, Maas F, et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies".
1737:
Krishnan NS, Higgins RM, Lam FT, et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation".
787: 768: 136: 1206:
Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR".
1845: 1704:"Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome" 1821: 1840: 1188: 1170: 300: 1042: 277: 1035: 1282: 1157: 1136: 199: 174: 1153: 47: 1132: 313: 212: 116: 1241:
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997).
306: 205: 1814: 832: 124: 1669:"Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1" 813: 1807: 188: 1526: 103: 1014: 1010: 985: 981: 977: 973: 947: 939: 918: 910: 906: 902: 1626: 1501: 1458: 148: 1515:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" 1018: 989: 943: 914: 1754: 1725: 1690: 1655: 1618: 1583: 1554: 1493: 1450: 1415: 1386: 1357: 1328: 1264: 1223: 144: 96: 40: 1791: 1746: 1715: 1680: 1647: 1608: 1575: 1544: 1534: 1483: 1440: 1407: 1378: 1349: 1318: 1310: 1254: 1215: 393: 324: 268: 223: 558: 551: 368: 107:, HA-1, HLA-HA1, HMHA1, histocompatibility (minor) HA-1, Rho GTPase activating protein 45 1530: 1750: 1651: 1219: 1549: 1514: 1353: 1314: 702: 697: 692: 687: 682: 666: 661: 656: 651: 646: 641: 636: 631: 626: 610: 605: 600: 1834: 1787: 1445: 1428: 587: 1630: 1505: 1462: 128: 386: 165: 152: 1193:
National Center for Biotechnology Information, U.S. National Library of Medicine
1175:
National Center for Biotechnology Information, U.S. National Library of Medicine
1685: 1668: 1488: 1471: 1411: 469: 285: 182: 132: 1259: 1242: 1597:"Complete sequencing and characterization of 21,243 full-length human cDNAs" 1429:"Expression of minor histocompatibility antigen, HA-1, in solid tumor cells" 732: 529: 407: 352: 339: 251: 238: 140: 1758: 1729: 1694: 1659: 1622: 1587: 1579: 1558: 1539: 1497: 1454: 1419: 1390: 1382: 1361: 1720: 1703: 1332: 1268: 1227: 1082: 1077: 1066: 877: 858: 1098: 844: 799: 73: 69: 1323: 1050: 754: 1775: 1667:
Mommaas B, Stegehuis-Kamp JA, van Halteren AG, et al. (2005).
1613: 1596: 717: 713: 1783: 1105: 567: 120: 1513:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
376: 1795: 693:
regulation of small GTPase mediated signal transduction
1702:
Harangi M, Kaminski WE, Fleck M, et al. (2005).
541: 1283:"Entrez Gene: HMHA1 histocompatibility (minor) HA-1" 1470:Mutis T, Blokland E, Kester M, et al. (2002). 1003: 966: 932: 895: 1595:Ota T, Suzuki Y, Nishikawa T, et al. (2004). 1149: 1147: 1145: 1128: 1126: 1124: 323: 222: 1427:Fujii N, Hiraki A, Ikeda K, et al. (2002). 16:Protein-coding gene in the species Homo sapiens 1154:GRCm38: Ensembl release 89: ENSMUSG00000035697 1815: 8: 1133:GRCh38: Ensembl release 89: ENSG00000180448 1822: 1808: 728: 583: 364: 263: 160: 58: 1719: 1684: 1612: 1548: 1538: 1487: 1444: 1322: 1258: 1120: 683:positive regulation of GTPase activity 18: 1095:Minor histocompatibility protein HA-1 328: 289: 284: 227: 186: 181: 7: 1772: 1770: 1794:. You can help Knowledge (XXG) by 1751:10.1016/j.transproceed.2007.02.066 1652:10.1016/j.transproceed.2004.06.007 1220:10.1111/j.1399-0039.1998.tb03053.x 1000: 963: 929: 892: 868: 849: 823: 804: 778: 759: 546: 464: 402: 381: 14: 1354:10.1034/j.1399-0039.2000.560109.x 1101:that in humans is encoded by the 688:intracellular signal transduction 1774: 1446:10.1097/00007890-200204150-00022 557: 550: 312: 305: 299: 276: 211: 204: 198: 173: 1846:Human chromosome 19 gene stubs 568:More reference expression data 530:More reference expression data 1: 1371:Biochem. Biophys. Res. Commun 1315:10.1016/S0966-3274(96)80009-8 297: 196: 1841:Genes on human chromosome 19 1519:Proc. Natl. Acad. Sci. U.S.A 512:subcutaneous adipose tissue 1862: 1769: 1686:10.1182/blood-2004-07-2832 1489:10.1182/blood-2002-01-0024 1189:"Mouse PubMed Reference:" 1171:"Human PubMed Reference:" 1081: 1076: 1072: 1065: 1049: 1030: 1007: 970: 959: 936: 899: 888: 875: 871: 856: 852: 843: 830: 826: 811: 807: 798: 785: 781: 766: 762: 753: 738: 731: 727: 711: 611:GTPase activator activity 586: 582: 565: 549: 540: 527: 476: 467: 414: 405: 375: 367: 363: 346: 333: 296: 275: 266: 262: 245: 232: 195: 172: 163: 159: 114: 111: 101: 94: 89: 66: 61: 44: 39: 34: 30: 26: 21: 1043:Chr 10: 79.85 – 79.87 Mb 703:neutrophil degranulation 642:azurophil granule lumen 637:secretory granule lumen 1580:10.1038/sj.thj.6200318 1540:10.1073/pnas.242603899 1412:10.1038/sj/thj/6200065 1383:10.1006/bbrc.2000.3880 1260:10.1093/dnares/3.5.321 1036:Chr 19: 1.07 – 1.09 Mb 488:mesenteric lymph nodes 1721:10.1002/eji.200425406 508:stroma of bone marrow 291:Chromosome 10 (mouse) 189:Chromosome 19 (human) 632:extracellular region 153:ARHGAP45 - orthologs 62:List of PDB id codes 35:Available structures 1531:2002PNAS...9916899M 1525:(26): 16899–16903. 698:signal transduction 1782:This article on a 833:ENSMUSG00000035697 676:Biological process 620:Cellular component 594:Molecular function 500:tibiofemoral joint 1803: 1802: 1092: 1091: 1088: 1087: 1061: 1060: 1026: 1025: 997: 996: 955: 954: 926: 925: 884: 883: 865: 864: 839: 838: 820: 819: 794: 793: 775: 774: 723: 722: 606:metal ion binding 578: 577: 574: 573: 536: 535: 523: 522: 461: 460: 454:bone marrow cells 359: 358: 258: 257: 85: 84: 81: 80: 45:Ortholog search: 1853: 1824: 1817: 1810: 1778: 1771: 1762: 1745:(5): 1439–1445. 1739:Transplant. Proc 1733: 1723: 1698: 1688: 1679:(4): 1823–1827. 1663: 1646:(6): 1735–1738. 1640:Transplant. Proc 1634: 1616: 1591: 1562: 1552: 1542: 1509: 1491: 1466: 1448: 1439:(7): 1137–1141. 1423: 1394: 1365: 1336: 1326: 1303:Transpl. Immunol 1287: 1286: 1279: 1273: 1272: 1262: 1238: 1232: 1231: 1203: 1197: 1196: 1185: 1179: 1178: 1167: 1161: 1151: 1140: 1130: 1074: 1073: 1045: 1038: 1021: 1001: 992: 964: 960:RefSeq (protein) 950: 930: 921: 893: 869: 850: 824: 805: 779: 760: 729: 584: 570: 561: 554: 547: 532: 472: 470:Top expressed in 465: 434:secondary oocyte 410: 408:Top expressed in 403: 382: 365: 355: 342: 331: 316: 309: 303: 292: 280: 264: 254: 241: 230: 215: 208: 202: 191: 177: 161: 155: 106: 99: 76: 59: 53: 32: 31: 19: 1861: 1860: 1856: 1855: 1854: 1852: 1851: 1850: 1831: 1830: 1829: 1828: 1767: 1765: 1736: 1708:Eur. J. Immunol 1701: 1666: 1637: 1594: 1565: 1512: 1469: 1433:Transplantation 1426: 1397: 1368: 1342:Tissue Antigens 1339: 1300: 1296: 1294:Further reading 1291: 1290: 1281: 1280: 1276: 1240: 1239: 1235: 1208:Tissue Antigens 1205: 1204: 1200: 1187: 1186: 1182: 1169: 1168: 1164: 1152: 1143: 1131: 1122: 1117: 1111: 1083:View/Edit Mouse 1078:View/Edit Human 1041: 1034: 1031:Location (UCSC) 1017: 1013: 1009: 988: 984: 980: 976: 972: 946: 942: 938: 917: 913: 909: 905: 901: 814:ENSG00000180448 707: 671: 667:cell projection 662:ruffle membrane 652:plasma membrane 615: 601:protein binding 566: 556: 555: 528: 519: 514: 510: 506: 502: 498: 494: 490: 486: 482: 468: 457: 452: 448: 444: 440: 436: 432: 428: 424: 420: 406: 350: 337: 329: 319: 318: 317: 310: 290: 267:Gene location ( 249: 236: 228: 218: 217: 216: 209: 187: 164:Gene location ( 115: 102: 95: 68: 46: 17: 12: 11: 5: 1859: 1857: 1849: 1848: 1843: 1833: 1832: 1827: 1826: 1819: 1812: 1804: 1801: 1800: 1779: 1764: 1763: 1734: 1714:(1): 305–317. 1699: 1664: 1635: 1614:10.1038/ng1285 1592: 1574:(5): 315–320. 1563: 1510: 1482:(2): 547–552. 1467: 1424: 1395: 1377:(3): 782–789. 1366: 1337: 1309:(2): 151–157. 1297: 1295: 1292: 1289: 1288: 1274: 1253:(5): 321–329. 1233: 1214:(4): 312–317. 1198: 1180: 1162: 1141: 1119: 1118: 1116: 1113: 1090: 1089: 1086: 1085: 1080: 1070: 1069: 1063: 1062: 1059: 1058: 1056: 1054: 1047: 1046: 1039: 1032: 1028: 1027: 1024: 1023: 1005: 1004: 998: 995: 994: 968: 967: 961: 957: 956: 953: 952: 934: 933: 927: 924: 923: 897: 896: 890: 886: 885: 882: 881: 873: 872: 866: 863: 862: 854: 853: 847: 841: 840: 837: 836: 828: 827: 821: 818: 817: 809: 808: 802: 796: 795: 792: 791: 783: 782: 776: 773: 772: 764: 763: 757: 751: 750: 745: 740: 736: 735: 725: 724: 721: 720: 709: 708: 706: 705: 700: 695: 690: 685: 679: 677: 673: 672: 670: 669: 664: 659: 654: 649: 644: 639: 634: 629: 623: 621: 617: 616: 614: 613: 608: 603: 597: 595: 591: 590: 580: 579: 576: 575: 572: 571: 563: 562: 544: 538: 537: 534: 533: 525: 524: 521: 520: 518: 517: 513: 509: 505: 501: 497: 493: 489: 485: 481: 477: 474: 473: 462: 459: 458: 456: 455: 451: 447: 443: 439: 435: 431: 427: 423: 419: 415: 412: 411: 399: 398: 390: 379: 373: 372: 369:RNA expression 361: 360: 357: 356: 348: 344: 343: 335: 332: 327: 321: 320: 311: 304: 298: 294: 293: 288: 282: 281: 273: 272: 260: 259: 256: 255: 247: 243: 242: 234: 231: 226: 220: 219: 210: 203: 197: 193: 192: 185: 179: 178: 170: 169: 157: 156: 113: 109: 108: 100: 92: 91: 87: 86: 83: 82: 79: 78: 64: 63: 55: 54: 43: 37: 36: 28: 27: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1858: 1847: 1844: 1842: 1839: 1838: 1836: 1825: 1820: 1818: 1813: 1811: 1806: 1805: 1799: 1797: 1793: 1789: 1788:chromosome 19 1785: 1780: 1777: 1773: 1768: 1760: 1756: 1752: 1748: 1744: 1740: 1735: 1731: 1727: 1722: 1717: 1713: 1709: 1705: 1700: 1696: 1692: 1687: 1682: 1678: 1674: 1670: 1665: 1661: 1657: 1653: 1649: 1645: 1641: 1636: 1632: 1628: 1624: 1620: 1615: 1610: 1606: 1602: 1598: 1593: 1589: 1585: 1581: 1577: 1573: 1569: 1564: 1560: 1556: 1551: 1546: 1541: 1536: 1532: 1528: 1524: 1520: 1516: 1511: 1507: 1503: 1499: 1495: 1490: 1485: 1481: 1477: 1473: 1468: 1464: 1460: 1456: 1452: 1447: 1442: 1438: 1434: 1430: 1425: 1421: 1417: 1413: 1409: 1406:(6): 403–10. 1405: 1401: 1396: 1392: 1388: 1384: 1380: 1376: 1372: 1367: 1363: 1359: 1355: 1351: 1347: 1343: 1338: 1334: 1330: 1325: 1320: 1316: 1312: 1308: 1304: 1299: 1298: 1293: 1284: 1278: 1275: 1270: 1266: 1261: 1256: 1252: 1248: 1244: 1237: 1234: 1229: 1225: 1221: 1217: 1213: 1209: 1202: 1199: 1194: 1190: 1184: 1181: 1176: 1172: 1166: 1163: 1159: 1155: 1150: 1148: 1146: 1142: 1138: 1134: 1129: 1127: 1125: 1121: 1114: 1112: 1109: 1107: 1104: 1100: 1096: 1084: 1079: 1075: 1071: 1068: 1064: 1057: 1055: 1052: 1048: 1044: 1040: 1037: 1033: 1029: 1022: 1020: 1016: 1012: 1006: 1002: 999: 993: 991: 987: 983: 979: 975: 969: 965: 962: 958: 951: 949: 945: 941: 935: 931: 928: 922: 920: 916: 912: 908: 904: 898: 894: 891: 889:RefSeq (mRNA) 887: 880: 879: 874: 870: 867: 861: 860: 855: 851: 848: 846: 842: 835: 834: 829: 825: 822: 816: 815: 810: 806: 803: 801: 797: 790: 789: 784: 780: 777: 771: 770: 765: 761: 758: 756: 752: 749: 746: 744: 741: 737: 734: 730: 726: 719: 715: 710: 704: 701: 699: 696: 694: 691: 689: 686: 684: 681: 680: 678: 675: 674: 668: 665: 663: 660: 658: 655: 653: 650: 648: 645: 643: 640: 638: 635: 633: 630: 628: 625: 624: 622: 619: 618: 612: 609: 607: 604: 602: 599: 598: 596: 593: 592: 589: 588:Gene ontology 585: 581: 569: 564: 560: 553: 548: 545: 543: 539: 531: 526: 515: 511: 507: 503: 499: 495: 491: 487: 483: 479: 478: 475: 471: 466: 463: 453: 449: 445: 441: 437: 433: 429: 425: 421: 417: 416: 413: 409: 404: 401: 400: 397: 395: 391: 389: 388: 384: 383: 380: 378: 374: 370: 366: 362: 354: 349: 345: 341: 336: 330:10|10 C1 326: 322: 315: 308: 302: 295: 287: 283: 279: 274: 270: 265: 261: 253: 248: 244: 240: 235: 225: 221: 214: 207: 201: 194: 190: 184: 180: 176: 171: 167: 162: 158: 154: 150: 146: 142: 138: 134: 130: 126: 122: 118: 110: 105: 98: 93: 88: 77: 75: 71: 65: 60: 57: 56: 52: 49: 42: 38: 33: 29: 25: 20: 1796:expanding it 1781: 1766: 1742: 1738: 1711: 1707: 1676: 1672: 1643: 1639: 1607:(1): 40–45. 1604: 1600: 1571: 1567: 1522: 1518: 1479: 1475: 1436: 1432: 1403: 1399: 1374: 1370: 1348:(1): 69–76. 1345: 1341: 1306: 1302: 1277: 1250: 1246: 1236: 1211: 1207: 1201: 1192: 1183: 1174: 1165: 1110: 1102: 1094: 1093: 1015:NP_001334003 1011:NP_001136173 1008: 986:NP_001308161 982:NP_001269264 978:NP_001269263 974:NP_001245257 971: 948:NM_001347074 940:NM_001142701 937: 919:NM_001321232 911:NM_001282335 907:NM_001282334 903:NM_001258328 900: 876: 857: 831: 812: 786: 767: 747: 742: 392: 385: 112:External IDs 67: 516:ankle joint 504:bone marrow 480:granulocyte 418:granulocyte 351:79,867,306 338:79,852,487 90:Identifiers 1835:Categories 1601:Nat. Genet 1568:Hematol. J 1400:Hematol. J 1160:, May 2017 1139:, May 2017 1115:References 442:lymph node 396:(ortholog) 250:1,086,628 237:1,065,923 133:HomoloGene 1786:on human 1324:1887/2991 1019:NP_081797 990:NP_036424 944:NM_027521 915:NM_012292 733:Orthologs 647:cytoplasm 141:GeneCards 1759:17580157 1730:15593299 1695:15498856 1660:15350465 1631:21903526 1623:14702039 1588:14502255 1559:12477932 1506:31440495 1498:12091347 1463:21504762 1455:11965046 1420:11920221 1391:11095984 1362:10958358 1156:– 1135:– 1067:Wikidata 712:Sources: 657:membrane 450:appendix 438:monocyte 145:ARHGAP45 104:ARHGAP45 22:ARHGAP45 1527:Bibcode 1333:8843592 1269:9039502 1247:DNA Res 1228:9820596 1158:Ensembl 1137:Ensembl 1099:protein 845:UniProt 800:Ensembl 739:Species 718:QuickGO 627:cytosol 371:pattern 229:19p13.3 129:1917969 97:Aliases 1757:  1728:  1693:  1658:  1629:  1621:  1586:  1557:  1550:139241 1547:  1504:  1496:  1461:  1453:  1418:  1389:  1360:  1331:  1267:  1226:  1053:search 1051:PubMed 878:Q3TBD2 859:Q92619 755:Entrez 542:BioGPS 496:spleen 484:thymus 446:thymus 430:oocyte 426:spleen 121:601155 1790:is a 1673:Blood 1627:S2CID 1502:S2CID 1476:Blood 1459:S2CID 1103:HMHA1 1097:is a 788:70719 769:23526 748:Mouse 743:Human 714:Amigo 492:blood 422:blood 394:Mouse 387:Human 334:Start 269:Mouse 233:Start 166:Human 137:69120 1792:stub 1784:gene 1755:PMID 1726:PMID 1691:PMID 1656:PMID 1619:PMID 1584:PMID 1555:PMID 1494:PMID 1451:PMID 1416:PMID 1387:PMID 1358:PMID 1329:PMID 1265:PMID 1224:PMID 1106:gene 377:Bgee 325:Band 286:Chr. 224:Band 183:Chr. 117:OMIM 74:3FT3 70:3D25 51:RCSB 48:PDBe 1747:doi 1716:doi 1681:doi 1677:105 1648:doi 1609:doi 1576:doi 1545:PMC 1535:doi 1484:doi 1480:100 1441:doi 1408:doi 1379:doi 1375:278 1350:doi 1319:hdl 1311:doi 1255:doi 1216:doi 347:End 246:End 149:OMA 125:MGI 41:PDB 1837:: 1753:. 1743:39 1741:. 1724:. 1712:35 1710:. 1706:. 1689:. 1675:. 1671:. 1654:. 1644:36 1642:. 1625:. 1617:. 1605:36 1603:. 1599:. 1582:. 1570:. 1553:. 1543:. 1533:. 1523:99 1521:. 1517:. 1500:. 1492:. 1478:. 1474:. 1457:. 1449:. 1437:73 1435:. 1431:. 1414:. 1402:. 1385:. 1373:. 1356:. 1346:56 1344:. 1327:. 1317:. 1305:. 1263:. 1249:. 1245:. 1222:. 1212:52 1210:. 1191:. 1173:. 1144:^ 1123:^ 1108:. 716:/ 353:bp 340:bp 252:bp 239:bp 147:; 143:: 139:; 135:: 131:; 127:: 123:; 119:: 72:, 1823:e 1816:t 1809:v 1798:. 1761:. 1749:: 1732:. 1718:: 1697:. 1683:: 1662:. 1650:: 1633:. 1611:: 1590:. 1578:: 1572:4 1561:. 1537:: 1529:: 1508:. 1486:: 1465:. 1443:: 1422:. 1410:: 1404:1 1393:. 1381:: 1364:. 1352:: 1335:. 1321:: 1313:: 1307:4 1285:. 1271:. 1257:: 1251:3 1230:. 1218:: 1195:. 1177:. 271:) 168:) 151::

Index

PDB
PDBe
RCSB
3D25
3FT3
Aliases
ARHGAP45
OMIM
601155
MGI
1917969
HomoloGene
69120
GeneCards
ARHGAP45
OMA
ARHGAP45 - orthologs
Human
Chromosome 19 (human)
Chr.
Chromosome 19 (human)
Chromosome 19 (human)
Genomic location for ARHGAP45
Genomic location for ARHGAP45
Band
bp
bp
Mouse
Chromosome 10 (mouse)
Chr.

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