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gene expression and as a consequence it may inhibit tumor cell growth. Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme glutamyl-prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal
483:, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function. Halofuginone therefore has potential for the treatment of autoimmune disorders.
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Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A (June 2009).
60:
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InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/m0/s1
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522:. National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services.
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614:"Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response"
557:"Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response"
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Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, et al. (June 2009).
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Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, et al. (February 2012).
464:(Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of
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685:"Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase"
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495:, which in turn exerts anti-inflammatory and anti-fibrotic effects.
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534:"Halofuginone Receives FDA Orphan Drug Status For Scleroderma"
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458:alkaloid which can be found in the Chinese herb
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146:7-Bromo-6-chloro-3--2-oxopropyl]-4-quinazolinone
446:used in veterinary medicine. It is a synthetic
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8:
19:
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382:O=C(CN3C=NC2=CC(Br)=C(Cl)C=C2C3=O)C1NCCC1O
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479:Halofuginone inhibits the development of
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486:Halofuginone is also an inhibitor of
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664:"A new lead for autoimmune disease"
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474:U.S. Food and Drug Administration
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540:. 10 March 2000. Archived from
407:Key:LVASCWIMLIKXLA-LSDHHAIUSA-N
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493:amino acid starvation response
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1:
670:(Press release). 4 June 2009.
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516:"Halofuginone hydrobromide"
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292:Chemical and physical data
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71:International Drug Names
689:Nature Chemical Biology
638:10.1126/science.1172638
581:10.1126/science.1172638
472:designation from the
739:Antiparasitic agents
701:10.1038/nchembio.790
468:and it has received
630:2009Sci...324.1334S
573:2009Sci...324.1334S
520:NCI Drug Dictionary
23:
759:Secondary alcohols
481:T helper 17 cells
461:Dichroa febrifuga
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361:Interactive image
261:CompTox Dashboard
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16:Chemical compound
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749:Chloroarenes
695:(3): 311–7.
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454:, a natural
444:coccidiostat
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436:Halofuginone
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109:Legal status
103:Legal status
21:Halofuginone
754:Piperidines
744:Bromoarenes
668:EurekAlert!
470:orphan drug
466:scleroderma
452:febrifugine
448:halogenated
344: g·mol
130:Identifiers
79:ATCvet code
51:Trade names
733:Categories
499:References
349:3D model (
337:Molar mass
230:L31MM1385E
201:ChemSpider
165:55837-20-2
156:CAS Number
139:IUPAC name
65:Drugs.com
719:22327401
656:19498172
599:19498172
426:(verify)
87:QP51BX01
769:Lactams
710:3281520
647:2803727
626:Bibcode
618:Science
590:2803727
569:Bibcode
561:Science
538:WebCite
442:, is a
440:Halocur
298:Formula
176:PubChem
95:)
89: (
55:Halocur
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375:SMILES
342:414.68
241:ChEMBL
210:355164
190:400772
395:InChI
351:JSmol
715:PMID
652:PMID
595:PMID
221:UNII
61:AHFS
705:PMC
697:doi
642:PMC
634:doi
622:324
585:PMC
577:doi
565:324
266:EPA
180:CID
92:WHO
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318:Cl
315:Br
312:17
306:16
118:EU
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330:3
327:O
324:3
321:N
309:H
303:C
268:)
264:(
120::
63:/
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