277:. Almost all his subsequent research focused on this class of proteins, the elucidation of their physiological functions, and the factors that influenced their expression and release – including other growth factors, the presynaptic release of neurotransmitters, glucocorticosteroids, and stress. His work has been instrumental in demonstrating the importance of neurotrophins for brain plasticity (the formation and pruning of synaptic connections in, for example, learning and memory), and has pursued their relevance for remediating nerve damage and dementia.
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While testing dopamine analogues at
Hoffman-LaRoche, he was surprised by the toxicity of 6-hydroxydopamine on sympathetic nerves and investigated its mechanisms of action. Its selective effect on dopaminergic neurons has made it a useful tool in
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This line of research had an unexpected payoff. While working with
Axelrod at NIMH, Thoenen discovered that repeated stimulation of the adrenal medulla led to increased levels of the monoamine synthesis enzyme
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210:, graduating in 1953 and receiving his doctorate from Bern in 1957. In 1961 he joined the research laboratories of the Swiss pharmaceutical company
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and other neurotrophins. His laboratory made a series of groundbreaking contributions to the field, including the cloning of
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262:. Trans-synaptic enzyme induction had never previously been detected: it transpired that it was a general phenomenon.
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398:"Hans Thoenen: A modest man whose discoveries had a lasting impact on modern neuroscience"
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for
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had offered him the directorship of a new institute – what is now the
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570:"Society for Neuroscience – Ralph W. Gerard Prize in Neuroscience"
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as research group leader in
Neurobiology. In 1977 he relocated to
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Members of the German
National Academy of Sciences Leopoldina
333:. He received honorary doctorates from the Universities of
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Award for
Pioneering Achievement in Health (1994) and the
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Foreign associates of the
National Academy of Sciences
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The
History of Neuroscience in Autobiography Volume 6
214:, leaving in 1968 to spend a year working with the
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596:"Shooter honored by Bristol-Myers Squibb: 9/10/97"
490:"Previous prizewinners of the Feldberg Foundation"
625:[Ernst Jung Prize for Medicine awarded].
202:Thoenen studied medicine at the Universities of
402:Proceedings of the National Academy of Sciences
313:Neuropsychopharmacology Award (1996), and the
460:. Oxford University Press. pp. 515–568.
238:– which he led until his retirement in 1996.
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466:10.1093/acprof:oso/9780195380101.003.0014
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623:"Ernst-Jung-Preis für Medizin vergeben"
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368:Max-Planck-Institut für Neurobiologie
327:German Academy of Sciences Leopoldina
303:Ralph W. Gerard Prize in Neuroscience
236:Max Planck Institute for Neurobiology
222:. In 1971 he joined the newly-formed
149:Max Planck Institute for Neurobiology
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224:Biocentre at the University of Basel
396:Iversen, L. L. (17 December 2012).
232:Max Planck Institute for Psychiatry
155:Max Planck Institute for Psychiatry
265:At Basel, his attention turned to
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452:Squire, Larry R. (1 March 2009).
271:brain derived neurotrophic factor
325:in 2007. He was a member of the
182:, Switzerland – 23 June 2012 in
621:Grosse, Angela (12 May 2007).
160:Biozentrum University of Basel
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732:21st-century Swiss physicians
727:21st-century Swiss biologists
722:20th-century Swiss physicians
717:20th-century Swiss biologists
679:National Academy of Sciences
331:National Academy of Sciences
329:and a foreign member of the
112:Charles A. Dana Award (1994)
364:"Hans Thoenen, 1928 – 2012"
275:ciliary neurotrophic factor
190:best known for his work on
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315:Bristol-Myers Squibb Award
98:Bristol-Myers Squibb Award
757:University of Bern alumni
299:Neuronal Plasticity Prize
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108:Neuronal Plasticity Prize
574:Society for Neuroscience
541:"Our Prizes (1983–2018)"
307:Society for Neuroscience
301:(1994). He received the
494:The Feldberg Foundation
415:10.1073/pnas.1218423110
186:, Germany) was a Swiss
747:Swiss neuroscientists
323:Ernst Jung Gold Medal
321:. He was awarded the
103:Ralph W. Gerard Prize
93:Ernst Jung Gold Medal
627:Hamburger Abendblatt
519:Max Cloëtta Stiftung
260:tyrosine hydroxylase
267:nerve growth factor
252:Parkinson's disease
752:Swiss neurologists
602:. 1 September 2005
82:University of Bern
16:Swiss psychiatrist
649:"List of Members"
475:978-0-19-538010-1
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128:Scientific career
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675:"Hans Thoenen"
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576:. 15 June 2018
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454:"Hans Thoenen"
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287:Feldberg Award
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188:neurobiologist
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683:. Retrieved
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372:. Retrieved
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309:(1995), the
293:(1985), the
289:(1980), the
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176:Hans Thoenen
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144:Institutions
138:neurobiology
127:
56:(2012-06-23)
54:23 June 2012
23:Hans Thoenen
712:2012 deaths
707:1928 births
629:(in German)
550:. p. 3
521:(in German)
370:(in German)
73:Switzerland
70:Citizenship
701:Categories
685:17 October
659:17 October
653:Leopoldina
633:17 October
606:17 October
580:17 October
554:17 October
525:17 October
499:17 October
374:17 October
345:References
230:where the
180:Zweisimmen
43:Zweisimmen
39:5 May 1928
35:1928-05-05
424:0027-8424
218:group at
208:Innsbruck
198:Biography
84:(MD 1957)
78:Education
64:, Germany
408:(1): 4.
335:Würzburg
242:Research
433:3538249
305:of the
216:Axelrod
472:
430:
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339:Zurich
281:Awards
228:Munich
184:Munich
134:Fields
122:(1980)
117:(1985)
110:(1994)
105:(1995)
100:(1997)
95:(2007)
89:Awards
62:Munich
544:(PDF)
687:2018
661:2018
635:2018
608:2018
582:2018
556:2018
527:2018
501:2018
470:ISBN
420:ISSN
376:2018
337:and
311:ECNP
273:and
220:NIMH
206:and
204:Bern
51:Died
29:Born
462:doi
428:PMC
410:doi
406:110
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.