174:
199:
205:
31:
1696:
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG,
1280:
Guéant-Rodriguez RM, Juilliére Y, Candito M, Adjalla CE, Gibelin P, Herbeth B, Van
Obberghen E, Gueánt JL (Sep 2005). "Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population".
57:
1170:
Viola-Villegas N, Rabideau AE, Bartholomä M, Zubieta J, Doyle RP (Aug 2009). "Targeting the cubilin receptor through the vitamin B(12) uptake pathway: cytotoxicity and mechanistic insight through fluorescent Re(I) delivery".
1812:
Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, Lai S, Mulas A, Corsi AM, Vestrini A, Sofi F, Gori AM, Abbate R, Guralnik J, Singleton A, Abecasis GR, Schlessinger D, Uda M, Ferrucci L (Apr 2009).
1623:
Fedosov SN, Fedosova NU, Kräutler B, Nexø E, Petersen TE (May 2007). "Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins".
936:
found in the stomach secretions, and easily denatures in that environment before it has a chance to be absorbed by the small intestine. Found in fresh animal products (such as liver), vitamin B
2008:
Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (Jun 2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry".
2039:"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study"
1022:. This is conjectured to be a circulating storage function. Several serious, even life-threatening diseases cause elevated serum HC, measured as abnormally high serum vitamin B
212:
1971:
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer".
1740:
Collin SM, Metcalfe C, Refsum H, Lewis SJ, Smith GD, Cox A, Davis M, Marsden G, Johnston C, Lane JA, Donovan JL, Neal DE, Hamdy FC, Smith AD, Martin RM (Nov 2010).
1742:"Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer"
1361:
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (Dec 2009).
1655:"Genomic mutations associated with mild and severe deficiencies of transcobalamin I (haptocorrin) that cause mildly and severely low serum cobalamin levels"
1856:
Geisel J, Hübner U, Bodis M, Schorr H, Knapp JP, Obeid R, Herrmann W (Nov 2003). "The role of genetic factors in the development of hyperhomocysteinemia".
1775:
Haggarty P, Campbell DM, Duthie S, Andrews K, Hoad G, Piyathilake C, Fraser I, McNeill G (Jun 2008). "Folic acid use in pregnancy and embryo selection".
1895:"Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate"
135:
577:
2090:
1580:
Wang SS, Maurer MJ, Morton LM, Habermann TM, Davis S, Cozen W, Lynch CF, Severson RK, Rothman N, Chanock SJ, Hartge P, Cerhan JR (Mar 2009).
1063:
995:–IF complex. This complex then travels through the small bowel and reaches the terminal tertiary portion of the small intestine, called the
1582:"Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma"
1451:
Lee KM, Lan Q, Kricker A, Purdue MP, Grulich AE, Vajdic CM, Turner J, Whitby D, Kang D, Chanock S, Rothman N, Armstrong BK (Dec 2007).
786:
1111:
893:
Haptocorrin (HC), also commonly known as the R-protein, or the R-factor, or previously referred to as transcobalamin I, is a unique
1081:
1050:
897:
produced by the salivary glands of the oral cavity, in response to ingestion of food. This protein binds strongly to vitamin B
901:
in what is an intricate and necessary mechanism to protect this vitamin from the acidic environment of the stomach. Vitamin B
198:
173:
987:
is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa. In the duodenum, the free vitamin B
1241:
Ermens AA, Vlasveld LT, Lindemans J (November 2003). "Significance of elevated cobalamin (vitamin B12) levels in blood".
1046:
1936:
von Castel-Dunwoody KM, Kauwell GP, Shelnutt KP, Vaughn JD, Griffin ER, Maneval DR, Theriaque DW, Bailey LB (Jun 2005).
881:
while it moves through the stomach. A second function is serum HC binding of the great majority of circulating vitamin B
123:
1026:
while at the same time manifesting as a vitamin deficiency because of insufficient vitamin bound to transcobalamin II.
999:. The ileum is the longest of all portions of the small intestine, and has on its surface specialized receptors called
2037:
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (Oct 2010).
1893:
Martinelli M, Scapoli L, Palmieri A, Pezzetti F, Baciliero U, Padula E, Carinci P, Morselli PG, Carinci F (Mar 2006).
211:
2095:
1494:"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry"
204:
1320:"Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics"
1206:
McCorvie TJ, Ferreira D, Yue WW, Froese DS (May 2023). "The complex machinery of human cobalamin metabolism".
54:
885:, rendering it unavailable for take-up by cells. This is conjectured to be a circulating storage function.
620:
918:
1815:"Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations"
1697:
Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (Nov 2009).
187:
940:
attaches haptocorrin, which has a high affinity for its molecular structure. Coupled together vitamin B
1699:"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip"
110:
1405:
928:
is therefore an important vitamin for the body to absorb. Despite its vital role however, vitamin B
1537:"Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome"
1996:
1924:
1881:
1800:
1684:
1480:
1306:
1152:
147:
750:
705:
2068:
2025:
1988:
1959:
1916:
1873:
1844:
1792:
1763:
1728:
1676:
1641:
1611:
1568:
1523:
1472:
1439:
1410:"Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty"
1392:
1349:
1298:
1258:
1223:
1188:
1144:
1107:
933:
906:
103:
47:
867:
2058:
2050:
2017:
1980:
1949:
1906:
1865:
1834:
1826:
1784:
1753:
1718:
1710:
1666:
1633:
1601:
1593:
1558:
1548:
1513:
1505:
1464:
1429:
1421:
1382:
1374:
1339:
1331:
1290:
1250:
1215:
1180:
1136:
976:
961:
291:
222:
266:
143:
1453:"One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia"
2063:
2038:
1839:
1814:
1723:
1698:
1606:
1581:
1563:
1536:
1518:
1493:
1434:
1409:
1387:
1362:
1344:
1319:
1019:
1014:
Separate from the digestive absorption function, serum HC binds 80-90% of circulating B
983:
after its release from haptocorrin by digestion, and without which only 1% of vitamin B
972:
859:
1378:
1254:
511:
506:
501:
496:
491:
486:
470:
465:
460:
455:
439:
30:
2084:
1788:
1671:
1654:
1535:
Fintelman-Rodrigues N, Corrêa JC, Santos JM, Pimentel MM, Santos-Rebouças CB (2009).
426:
1928:
1885:
1804:
1688:
1484:
1310:
1156:
1938:"Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism"
914:
894:
284:
164:
1758:
1741:
1408:, Arking DE, Allen RH, Fried LP, Chakravarti A, Stabler SP, Fallin MD (Jan 2010).
1363:"Integrative predictive model of coronary artery calcification in atherosclerosis"
2000:
151:
1068:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1008:
875:
1830:
1714:
948:
complex is impervious to the insult of the stomach acid, and passes on via the
905:
is an essential water-soluble vitamin, the deficiency of which creates anemia (
1984:
1468:
1425:
181:
131:
1954:
1937:
1492:
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2005).
957:
874:. One essential function of haptocorrin is protection of the acid-sensitive
541:
384:
305:
250:
237:
139:
2072:
2029:
1992:
1963:
1920:
1877:
1848:
1796:
1767:
1732:
1680:
1645:
1615:
1572:
1527:
1476:
1443:
1396:
1353:
1302:
1262:
1227:
1192:
1148:
1869:
1553:
1140:
971:
The same cells in the stomach that produce gastric hydrochloric acid, the
1597:
1335:
1294:
953:
818:
663:
829:
1219:
1000:
949:
862:
649:
606:
2054:
2021:
1911:
1894:
1637:
1509:
1184:
80:
76:
910:
799:
563:
1452:
996:
526:
522:
1127:
Morkbak AL, Poulsen SS, Nexo E (2007). "Haptocorrin in humans".
871:
127:
1318:
Garrod MG, Allen LH, Haan MN, Green R, Miller JW (May 2010).
991:
attaches to the intrinsic factor (IF) to create a vitamin B
1007:–IF complexes and take them up into the circulation via
274:
917:), neurological problems, as well as metabolic issues (
396:
1018:, rendering it unavailable for cellular delivery by
944:
and haptocorrin create a complex. This haptocorrin–B
1097:
1095:
764:
743:
719:
698:
1042:
1040:
1038:
1106:. Blackwell Publishing Professional. p. 44.
221:
1746:Cancer Epidemiology, Biomarkers & Prevention
16:Protein-coding gene in the species Homo sapiens
8:
1414:The Journal of Nutrition, Health & Aging
1047:GRCh38: Ensembl release 89: ENSG00000134827
1942:The American Journal of Clinical Nutrition
1858:Clinical Chemistry and Laboratory Medicine
1129:Clinical Chemistry and Laboratory Medicine
909:), decreased bone marrow cell production (
537:
422:
262:
159:
65:
2062:
1953:
1910:
1838:
1757:
1722:
1670:
1653:Carmel R, Parker J, Kelman Z (Nov 2009).
1605:
1562:
1552:
1517:
1433:
1386:
1343:
1082:"Entrez Gene: transcobalamin I (vitamin B
964:) cleave haptocorrin, releasing vitamin B
1034:
1324:European Journal of Clinical Nutrition
932:is structurally very sensitive to the
114:, HC, TC-1, TC1, TCI, transcobalamin 1
20:
975:, also produce a molecule called the
226:
185:
180:
7:
1104:Essential Haematology 5e (Essential)
1819:American Journal of Human Genetics
1703:American Journal of Human Genetics
761:
740:
716:
695:
673:
654:
630:
611:
587:
568:
401:
362:
300:
279:
14:
1379:10.1161/CIRCULATIONAHA.109.865501
1255:10.1016/j.clinbiochem.2003.08.004
865:that in humans is encoded by the
1789:10.1111/j.1471-0528.2008.01737.x
1672:10.1111/j.1365-2141.2009.07855.x
210:
203:
197:
172:
29:
1659:British Journal of Haematology
1173:Journal of Medicinal Chemistry
1003:receptors, that identify the B
385:More reference expression data
320:olfactory zone of nasal mucosa
1:
1759:10.1158/1055-9965.EPI-10-0582
956:. In the duodenum pancreatic
195:
2091:Genes on human chromosome 11
2010:Journal of Proteome Research
1498:Journal of Proteome Research
487:cobalamin metabolic process
2112:
1831:10.1016/j.ajhg.2009.02.011
1715:10.1016/j.ajhg.2009.10.014
1283:Thrombosis and Haemostasis
1102:Pettit JD, Moss P (2006).
919:methylmalonyl-CoA acidosis
1985:10.1007/s00335-005-0075-2
1469:10.1007/s00439-007-0431-2
1426:10.1007/s12603-010-0013-1
1404:Matteini AM, Walston JD,
1064:"Human PubMed Reference:"
833:
828:
824:
817:
798:
781:
768:
747:
736:
723:
702:
691:
680:
676:
661:
657:
648:
637:
633:
618:
614:
605:
594:
590:
575:
571:
562:
547:
540:
536:
520:
425:
421:
409:
404:
395:
382:
369:
365:
312:
303:
273:
265:
261:
244:
231:
194:
171:
162:
158:
121:
118:
108:
101:
96:
73:
68:
51:
46:
41:
37:
28:
23:
787:Chr 11: 59.85 – 59.87 Mb
507:neutrophil degranulation
979:(IF), which binds the B
1955:10.1093/ajcn/81.6.1436
1011:-mediated absorption.
471:tertiary granule lumen
466:specific granule lumen
316:pancreatic ductal cell
52:Human UniProt search:
1870:10.1515/CCLM.2003.219
1141:10.1515/CCLM.2007.343
188:Chromosome 11 (human)
1598:10.1038/leu.2008.240
1336:10.1038/ejcn.2010.20
1295:10.1160/TH05-04-0262
492:cobalt ion transport
456:extracellular region
69:List of PDB id codes
42:Available structures
1554:10.1155/2009/504625
1208:J Inherit Metab Dis
846:(HC) also known as
502:cobalamin transport
461:extracellular space
1220:10.1002/jimd.12593
968:in its free form.
480:Biological process
449:Cellular component
433:Molecular function
2055:10.2337/dc10-0452
2022:10.1021/pr050492k
1912:10.1002/humu.9411
1638:10.1021/bi062063l
1510:10.1021/pr0502065
1185:10.1021/jm900777v
1020:transcobalamin II
934:hydrochloric acid
907:macrocytic anemia
841:
840:
837:
836:
813:
812:
777:
776:
758:
757:
732:
731:
713:
712:
687:
686:
670:
669:
644:
643:
627:
626:
601:
600:
584:
583:
532:
531:
440:cobalamin binding
417:
416:
413:
412:
391:
390:
378:
377:
359:
358:
340:bone marrow cells
257:
256:
92:
91:
88:
87:
2103:
2096:Digestive system
2076:
2066:
2033:
2004:
1973:Mammalian Genome
1967:
1957:
1932:
1914:
1889:
1852:
1842:
1808:
1771:
1761:
1736:
1726:
1692:
1674:
1649:
1619:
1609:
1576:
1566:
1556:
1531:
1521:
1488:
1447:
1437:
1400:
1390:
1357:
1347:
1314:
1267:
1266:
1238:
1232:
1231:
1203:
1197:
1196:
1167:
1161:
1160:
1124:
1118:
1117:
1099:
1090:
1089:
1086:binding protein"
1078:
1072:
1071:
1060:
1054:
1044:
977:intrinsic factor
962:pancreatic juice
960:(a component of
848:transcobalamin-1
826:
825:
809:
794:
789:
772:
762:
753:
741:
737:RefSeq (protein)
727:
717:
708:
696:
674:
655:
631:
612:
588:
569:
538:
423:
402:
387:
363:
344:nasal epithelium
308:
306:Top expressed in
301:
280:
263:
253:
240:
229:
214:
207:
201:
190:
176:
160:
154:
152:TCN1 - orthologs
113:
106:
83:
66:
60:
39:
38:
33:
21:
2111:
2110:
2106:
2105:
2104:
2102:
2101:
2100:
2081:
2080:
2079:
2036:
2016:(6): 1493–503.
2007:
1970:
1935:
1892:
1864:(11): 1427–34.
1855:
1811:
1774:
1739:
1695:
1652:
1632:(21): 6446–58.
1622:
1579:
1541:Disease Markers
1534:
1491:
1450:
1406:Bandeen-Roche K
1403:
1373:(24): 2448–54.
1360:
1317:
1279:
1275:
1273:Further reading
1270:
1240:
1239:
1235:
1205:
1204:
1200:
1179:(16): 5253–61.
1169:
1168:
1164:
1126:
1125:
1121:
1114:
1101:
1100:
1093:
1085:
1080:
1079:
1075:
1062:
1061:
1057:
1045:
1036:
1032:
1025:
1017:
1006:
994:
990:
986:
982:
967:
947:
943:
939:
931:
927:
904:
900:
891:
884:
879:
830:View/Edit Human
807:
792:
785:
782:Location (UCSC)
770:
749:
725:
704:
621:ENSG00000134827
516:
475:
444:
383:
374:
355:
350:
348:trabecular bone
346:
342:
338:
334:
330:
326:
322:
318:
304:
248:
235:
227:
217:
216:
215:
208:
186:
163:Gene location (
122:
109:
102:
75:
53:
17:
12:
11:
5:
2109:
2107:
2099:
2098:
2093:
2083:
2082:
2078:
2077:
2049:(10): 2250–3.
2034:
2005:
1979:(12): 942–54.
1968:
1948:(6): 1436–41.
1933:
1899:Human Mutation
1890:
1853:
1809:
1772:
1752:(11): 2833–8.
1737:
1693:
1650:
1620:
1592:(3): 596–602.
1577:
1532:
1504:(6): 2070–80.
1489:
1457:Human Genetics
1448:
1401:
1358:
1315:
1276:
1274:
1271:
1269:
1268:
1233:
1198:
1162:
1135:(12): 1751–9.
1119:
1112:
1091:
1083:
1073:
1055:
1033:
1031:
1028:
1023:
1015:
1004:
992:
988:
984:
980:
973:parietal cells
965:
945:
941:
937:
929:
925:
902:
898:
890:
887:
882:
877:
860:transcobalamin
839:
838:
835:
834:
832:
822:
821:
815:
814:
811:
810:
805:
803:
796:
795:
790:
783:
779:
778:
775:
774:
766:
765:
759:
756:
755:
745:
744:
738:
734:
733:
730:
729:
721:
720:
714:
711:
710:
700:
699:
693:
689:
688:
685:
684:
678:
677:
671:
668:
667:
659:
658:
652:
646:
645:
642:
641:
635:
634:
628:
625:
624:
616:
615:
609:
603:
602:
599:
598:
592:
591:
585:
582:
581:
573:
572:
566:
560:
559:
554:
549:
545:
544:
534:
533:
530:
529:
518:
517:
515:
514:
509:
504:
499:
494:
489:
483:
481:
477:
476:
474:
473:
468:
463:
458:
452:
450:
446:
445:
443:
442:
436:
434:
430:
429:
419:
418:
415:
414:
411:
410:
407:
406:
399:
393:
392:
389:
388:
380:
379:
376:
375:
373:
370:
367:
366:
360:
357:
356:
354:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
310:
309:
297:
296:
288:
277:
271:
270:
267:RNA expression
259:
258:
255:
254:
246:
242:
241:
233:
230:
225:
219:
218:
209:
202:
196:
192:
191:
184:
178:
177:
169:
168:
156:
155:
120:
116:
115:
107:
99:
98:
94:
93:
90:
89:
86:
85:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2108:
2097:
2094:
2092:
2089:
2088:
2086:
2074:
2070:
2065:
2060:
2056:
2052:
2048:
2044:
2043:Diabetes Care
2040:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2006:
2002:
1998:
1994:
1990:
1986:
1982:
1978:
1974:
1969:
1965:
1961:
1956:
1951:
1947:
1943:
1939:
1934:
1930:
1926:
1922:
1918:
1913:
1908:
1904:
1900:
1896:
1891:
1887:
1883:
1879:
1875:
1871:
1867:
1863:
1859:
1854:
1850:
1846:
1841:
1836:
1832:
1828:
1825:(4): 477–82.
1824:
1820:
1816:
1810:
1806:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1773:
1769:
1765:
1760:
1755:
1751:
1747:
1743:
1738:
1734:
1730:
1725:
1720:
1716:
1712:
1709:(5): 628–42.
1708:
1704:
1700:
1694:
1690:
1686:
1682:
1678:
1673:
1668:
1665:(3): 386–91.
1664:
1660:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1621:
1617:
1613:
1608:
1603:
1599:
1595:
1591:
1587:
1583:
1578:
1574:
1570:
1565:
1560:
1555:
1550:
1547:(4): 155–61.
1546:
1542:
1538:
1533:
1529:
1525:
1520:
1515:
1511:
1507:
1503:
1499:
1495:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1463:(5): 525–33.
1462:
1458:
1454:
1449:
1445:
1441:
1436:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1402:
1398:
1394:
1389:
1384:
1380:
1376:
1372:
1368:
1364:
1359:
1355:
1351:
1346:
1341:
1337:
1333:
1329:
1325:
1321:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1284:
1278:
1277:
1272:
1264:
1260:
1256:
1252:
1249:(8): 585–90.
1248:
1244:
1237:
1234:
1229:
1225:
1221:
1217:
1214:(3): 406–20.
1213:
1209:
1202:
1199:
1194:
1190:
1186:
1182:
1178:
1174:
1166:
1163:
1158:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1123:
1120:
1115:
1113:1-4051-3649-9
1109:
1105:
1098:
1096:
1092:
1087:
1077:
1074:
1069:
1065:
1059:
1056:
1052:
1048:
1043:
1041:
1039:
1035:
1029:
1027:
1021:
1012:
1010:
1002:
998:
978:
974:
969:
963:
959:
955:
951:
935:
922:
920:
916:
912:
908:
896:
888:
886:
880:
873:
870:
869:
864:
861:
857:
853:
849:
845:
831:
827:
823:
820:
816:
806:
804:
801:
797:
791:
788:
784:
780:
773:
767:
763:
760:
754:
752:
746:
742:
739:
735:
728:
722:
718:
715:
709:
707:
701:
697:
694:
692:RefSeq (mRNA)
690:
683:
679:
675:
672:
666:
665:
660:
656:
653:
651:
647:
640:
636:
632:
629:
623:
622:
617:
613:
610:
608:
604:
597:
593:
589:
586:
580:
579:
574:
570:
567:
565:
561:
558:
555:
553:
550:
546:
543:
539:
535:
528:
524:
519:
513:
510:
508:
505:
503:
500:
498:
497:ion transport
495:
493:
490:
488:
485:
484:
482:
479:
478:
472:
469:
467:
464:
462:
459:
457:
454:
453:
451:
448:
447:
441:
438:
437:
435:
432:
431:
428:
427:Gene ontology
424:
420:
408:
403:
400:
398:
394:
386:
381:
371:
368:
364:
361:
351:
347:
343:
339:
335:
331:
328:parotid gland
327:
323:
319:
315:
314:
311:
307:
302:
299:
298:
295:
293:
289:
287:
286:
282:
281:
278:
276:
272:
268:
264:
260:
252:
247:
243:
239:
234:
224:
220:
213:
206:
200:
193:
189:
183:
179:
175:
170:
166:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2046:
2042:
2013:
2009:
1976:
1972:
1945:
1941:
1902:
1898:
1861:
1857:
1822:
1818:
1783:(7): 851–6.
1780:
1776:
1749:
1745:
1706:
1702:
1662:
1658:
1629:
1626:Biochemistry
1625:
1589:
1585:
1544:
1540:
1501:
1497:
1460:
1456:
1417:
1413:
1370:
1366:
1330:(5): 503–9.
1327:
1323:
1289:(3): 510–5.
1286:
1282:
1246:
1243:Clin Biochem
1242:
1236:
1211:
1207:
1201:
1176:
1172:
1165:
1132:
1128:
1122:
1103:
1076:
1067:
1058:
1013:
970:
923:
915:pancytopenia
895:glycoprotein
892:
866:
856:cobalophilin
855:
851:
847:
843:
842:
769:
748:
724:
703:
681:
662:
638:
619:
595:
576:
556:
551:
290:
283:
119:External IDs
74:
18:
1420:(1): 73–7.
1367:Circulation
1009:endocytosis
844:Haptocorrin
336:bone marrow
332:gallbladder
249:59,866,489
236:59,852,800
97:Identifiers
2085:Categories
1905:(3): 294.
1053:, May 2017
1030:References
294:(ortholog)
132:HomoloGene
958:proteases
924:Vitamin B
889:Functions
876:vitamin B
751:NP_001053
706:NM_001062
542:Orthologs
512:transport
140:GeneCards
2073:20628086
2030:16740002
1993:16341674
1964:15941899
1929:39925478
1921:16470748
1886:24720114
1878:14656021
1849:19303062
1805:27260053
1797:18485163
1768:20852008
1733:19913121
1689:20530258
1681:19686235
1646:17487979
1616:18830263
1586:Leukemia
1573:19729796
1528:16335952
1485:21487646
1477:17891500
1444:20082058
1397:19948975
1354:20216556
1311:33572371
1303:16268464
1263:14636871
1228:36680553
1193:19627091
1157:24204285
1149:17990953
1049:–
954:duodenum
819:Wikidata
521:Sources:
352:testicle
2064:2945168
1840:2667971
1724:2775832
1607:3066015
1564:3833707
1519:1850943
1435:3042247
1388:2810344
1345:2864787
1051:Ensembl
1001:cubilin
952:to the
950:pylorus
863:protein
650:UniProt
607:Ensembl
548:Species
527:QuickGO
324:trachea
269:pattern
228:11q12.1
104:Aliases
2071:
2061:
2028:
1999:
1991:
1962:
1927:
1919:
1884:
1876:
1847:
1837:
1803:
1795:
1766:
1731:
1721:
1687:
1679:
1644:
1614:
1604:
1571:
1561:
1526:
1516:
1483:
1475:
1442:
1432:
1395:
1385:
1352:
1342:
1309:
1301:
1261:
1226:
1191:
1155:
1147:
1110:
911:anemia
802:search
800:PubMed
664:P20061
564:Entrez
397:BioGPS
128:189905
2001:69278
1997:S2CID
1925:S2CID
1882:S2CID
1801:S2CID
1685:S2CID
1481:S2CID
1307:S2CID
1153:S2CID
997:ileum
858:is a
854:) or
557:Mouse
552:Human
523:Amigo
292:Mouse
285:Human
232:Start
165:Human
136:47985
2069:PMID
2026:PMID
1989:PMID
1960:PMID
1917:PMID
1874:PMID
1845:PMID
1793:PMID
1777:BJOG
1764:PMID
1729:PMID
1677:PMID
1642:PMID
1612:PMID
1569:PMID
1524:PMID
1473:PMID
1440:PMID
1393:PMID
1350:PMID
1299:PMID
1259:PMID
1224:PMID
1189:PMID
1145:PMID
1108:ISBN
872:gene
868:TCN1
852:TC-1
578:6947
275:Bgee
223:Band
182:Chr.
144:TCN1
124:OMIM
111:TCN1
81:4KKJ
77:4KKI
58:RCSB
55:PDBe
24:TCN1
2059:PMC
2051:doi
2018:doi
1981:doi
1950:doi
1907:doi
1866:doi
1835:PMC
1827:doi
1785:doi
1781:115
1754:doi
1719:PMC
1711:doi
1667:doi
1663:147
1634:doi
1602:PMC
1594:doi
1559:PMC
1549:doi
1514:PMC
1506:doi
1465:doi
1461:122
1430:PMC
1422:doi
1383:PMC
1375:doi
1371:120
1340:PMC
1332:doi
1291:doi
1251:doi
1216:doi
1181:doi
1137:doi
921:).
808:n/a
793:n/a
771:n/a
726:n/a
682:n/a
639:n/a
596:n/a
405:n/a
372:n/a
245:End
148:OMA
48:PDB
2087::
2067:.
2057:.
2047:33
2045:.
2041:.
2024:.
2012:.
1995:.
1987:.
1977:16
1975:.
1958:.
1946:81
1944:.
1940:.
1923:.
1915:.
1903:27
1901:.
1897:.
1880:.
1872:.
1862:41
1860:.
1843:.
1833:.
1823:84
1821:.
1817:.
1799:.
1791:.
1779:.
1762:.
1750:19
1748:.
1744:.
1727:.
1717:.
1707:85
1705:.
1701:.
1683:.
1675:.
1661:.
1657:.
1640:.
1630:46
1628:.
1610:.
1600:.
1590:23
1588:.
1584:.
1567:.
1557:.
1545:26
1543:.
1539:.
1522:.
1512:.
1500:.
1496:.
1479:.
1471:.
1459:.
1455:.
1438:.
1428:.
1418:14
1416:.
1412:.
1391:.
1381:.
1369:.
1365:.
1348:.
1338:.
1328:64
1326:.
1322:.
1305:.
1297:.
1287:94
1285:.
1257:.
1247:36
1245:.
1222:.
1212:46
1210:.
1187:.
1177:52
1175:.
1151:.
1143:.
1133:45
1131:.
1094:^
1084:12
1066:.
1037:^
1024:12
1016:12
1005:12
993:12
989:12
985:12
981:12
966:12
946:12
942:12
938:12
930:12
926:12
913:,
903:12
899:12
883:12
878:12
525:/
251:bp
238:bp
146:;
142::
138:;
134::
130:;
126::
79:,
2075:.
2053::
2032:.
2020::
2014:5
2003:.
1983::
1966:.
1952::
1931:.
1909::
1888:.
1868::
1851:.
1829::
1807:.
1787::
1770:.
1756::
1735:.
1713::
1691:.
1669::
1648:.
1636::
1618:.
1596::
1575:.
1551::
1530:.
1508::
1502:4
1487:.
1467::
1446:.
1424::
1399:.
1377::
1356:.
1334::
1313:.
1293::
1265:.
1253::
1230:.
1218::
1195:.
1183::
1159:.
1139::
1116:.
1088:.
1070:.
850:(
167:)
150::
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