268:(Martinsried), worked as a clinical and research fellow at the Department of Neurology Tuebingen, received board certification (2004) and completed his habilitation (2004). In 2005 he was appointed as a professor of neurology and head of the clinical research group for MS and neuroimmunology in Wuerzburg and acted as a vice-chair of the Department of Neurology. In 2010 he was recruited to the University of Muenster, where he accepted the position as a director of the Department of Neurology – Inflammatory Diseases of the Nervous System and Neurooncology. Since 1 May 2013 he is director of the Department of Neurology in Muenster.
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projects on immune cell trafficking and explores biomarkers for the prognosis and therapy of multiple sclerosis. By establishing translational research projects, his work helps to further elucidate the question of how immune therapies in neurological diseases work and how new mechanisms of action can be developed. In his research projects, Wiendl pursues a translational approach, closely connecting laboratory work with patient care. With this objective, he also established a biobank at the
Department of Neurology Muenster. Wiendl was involved in the development of the monoclonal antibody
367:, Meyer C*, Bhatia U*, Yshii L*, Kleffner I*, Bauer J*, Tröscher A, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud D-A, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG*, Martin-Blondel G*,
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center 128 ("Multiple
Sclerosis") of the DFG and acts as a member of the steering committee of the excellence cluster "Cells in Motion" (CiM), funded by the German federal government. In 2019, Wiendl was one of the main initiators of the successful application for funds from the German government to build the "Body and Brain Institute" and since has been acting as speaker of the project.
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Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjević M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted
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Wiendl’s clinical and scientific work focusses on inflammatory diseases of the nervous system. Taking multiple sclerosis as an exemplary disease, he primarily investigates aspects of immunoregulation and the interaction between immune system and nervous system. Furthermore, Wiendl conducted research
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Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Göbel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfar A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kümpfel T, Meinl I, Niessen K, Gölz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth
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Klotz L*, Eschborn M*, Lindner M*, Liebmann M, Herold M, Janoschka C, Torres
Garrido B, Schulte-Mecklenbeck A, Gross CC, Breuer J, Hundehege P, Posevitz V, Pignolet B, Nebel G, Glander S, Freise N, Austermann J, Wirth T, Campbell GR, Schneider-Hohendorf T, Eveslage M, Brassat D, Schwab N, Loser K,
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Wiendl receives funds from the
European Union, the federal ministry for education and research (BMBF) for Germany and Nordrhein-Westfalen, the Deutsche Forschungsgesellschaft (DFG), the program for innovative medical research (IMF) of the medical faculty Muenster, the interdisciplinary center for
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which was approved in 2016 and exhibits a completely new mechanism of action in MS therapy, and
Ofatumumab. Heinz Wiendl helped to establish the multiple sclerosis network KKNMS (Krankheitsbezogenes Kompetenznetzwerk Multiple Sklerose). He is co-speaker of the transregional collaborative research
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Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells. J Exp Med.
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Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H. B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in
353:, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups. Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med 6;383(6):546-557.
407:, Selmaj K, Arnold DL, Havrdova E, Boyko A, Kaufman M, Rose J, Greenberg S, Sweetser M, Riester K, O'Neill G, Elkins J (2015) Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med 373(15):1418-1428.
385:, Schäfers M*, Sorokin L*(2016) Imaging Matrix Metalloproteinase Activity in Multiple Sclerosis as a Specific Marker of Leukocyte Penetration of the Blood-Brain Barrier. Sci Transl Med 8(364):364ra152. (*equal contribution)
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Kappos L, Wiendl H, Selmaj K, Arnold DL, Havrdova E, Boyko A, Kaufman M, Rose J, Greenberg S, Sweetser M, Riester K, O'Neill G, Elkins J. Daclizumab HYP versus
Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med.
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Wiendl is a member in the following academic societies: German
Society for Immunology (DGfI), German Society of Multiple Sclerosis (DMSG), German Society for Muscular Disease (DGM), German Society of Neurology (DGN),
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371:, Liblau R*. (2019). CD8 T cell-mediated endotheliopathy is a targetable mechanism of neuroinflammation in Susac syndrome. Nat Comm 10:5779. * equal contribution, *shared last authorship, equal correspondence
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Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjević M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG,
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Bittner S*, Ruck T*, Schuhmann MK, Herrmann AM, Maati HMO, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape H, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla H, Budde T,
392:(2016) B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A 113(41):E6182-E6191.
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Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T,
361:(2019) Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Sci Transl Med 11 (490):eaao5563. *equal contribution
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Gerdes LA, Janoschka C, Eveslage M, Mannig B, Wirth T, Schulte-Mecklenbeck A, Lauks S, Glau L, Gross CC, Tolosa E, Flierl-Hecht A, Ertl-Wagner B, Barkhof F, Meuth SG, KĂĽmpfel T,
400:(2016) Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A 113(21):E2973-2982.
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414:(2014) VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells. J Exp Med 211(9):1833-1846.
428:, Meuth SG* (2013) Endothelial TWIK-related potassium channel-1 (TREK 1) regulates immune-cell trafficking into the CNS. Nat Med 19:1161-1165. * equal contribution
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SG, Foley J, Chan A, Brassat D, Wiendl H. L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Neurology. 2013;81:865-71
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260:, North Carolina, and Bale University, Switzerland. He obtained his MD in 1996. In the following years, he was a scholar of the German Research Council (
240:) is a German neurologist and professor at the University Hospital Muenster. He is known for his works in the field of nervous system inflammation and
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Wiendl published more than 500 scientific works and reviews, books, book chapters and monographies (as of
November 2020). Selected publications:
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Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N,
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346:, Hohlfeld R, Klotz L. Immune signatures of prodromal multiple sclerosis in monozygotic twins. Proc Natl Acad Sci U S A. 117(35):21546-21556.
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Breuer J, Schwab N, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, Gross CC, Clausen BE, Weishaupt C, Luger TA, Meuth SG, Loser K,
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421:(2014) Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol 75(5):739-758.
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378:, Schwab N (2018) Sex bias in MHC I-associated shaping of the adaptive immune system. Proc Natl Acad Sci U S A 115(9):2168-2173.
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Gerwien H*, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer M, Opdenakker G,
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Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K,
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2004 Sobek award for MS research (young scientists’ award) of the German
Society of Multiple Sclerosis (DMSG)
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Schneider-Hohendorf T, Görlich D, Savola P, Kelkka T, Mustjoki S, Gross CC, Owens GC, Klotz L, Dornmair K,
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clinical research (IZKF) Muenster, the Else-Kroener-Fresenius-Stiftung and the RE Children’s
Foundation.
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It may require cleanup to comply with Knowledge (XXG)'s content policies, particularly
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2015 Sobek award for MS research of the German Society of Multiple Sclerosis (DMSG)
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by IL-2 receptor modulation. Proc Natl Acad Sci U S A. 2016;113(21):E2973-82.
612:"Body and Brain Institut: 70 Millionen Euro teures Forschungszentrum kommt"
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2003 Felix-Jerusalem award of the German Society for Muscular Disease (DGM)
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630:"Wiendl, Heinz at the International Society of Neuroimmunology – ISNI"
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587:"Cells in Motion Interfaculty Centre (CiM) | University of MĂĽnster"
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Roth J, Busch KB, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A,
709:"Multiple Sklerose-Forschung - Sobek MS-Forschungspreis verliehen"
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may have been created or edited in return for undisclosed payments
566:"SFB TR-128 | Transregional Collaborative Research Center (CRC)"
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Wiendl studied psychology and medicine from 1989 to 1996 at the
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spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A. 2016.
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Heinrich-Pette award of the German Society for Neurology (DGN)
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A major contributor to this article appears to have a
308:2017 Honorary professor at Sydney medical school
655:Medical faculty Muenster (11 December 2015).
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55:Learn how and when to remove these messages
221:Learn how and when to remove this message
107:Learn how and when to remove this message
757:University Clinic of Muenster: Neurology
541:"Literature on ofatumumab by H. Wiendl"
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434:H. Wiendl Publication list ResearchGate
663:from the original on 27 November 2016
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266:Max Planck Institute of Neurobiology
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87:. Please discuss further on the
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719:(12): 644. 30 December 2004.
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272:Scientific contribution
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286:Academic memberships
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