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presence of two variations of β-globin chains, β^6Glu → Val (HbS) and β^121Glu → Lys (Hb O-Arab), patients heterozygous for
Hemoglobin O-Arab had denser red cells, having similar traits to sickle cell disease, with few outliers of cells of normal density. From a study formulated at Harvard Medical School, the authors have concluded that "The erythrocytic pathogenesis of Hemoglobin O-Arab involves the dehydration of red cells due to the K:Cl cotransport system." The abnormality thus explains the severe pathology of the double heterozygote for Hemoglobin S and Hemoglobin O-Arab, leading to the conclusion of a correlation of these hemoglobins present to additional haemolytic risk factor.
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of laboratories that utilise high-performance liquid chromatography (HPLC) technology for identification of hemoglobin variants, increasing approximately 12.5 fold in over the past decade. It is of clinical significance to be able to differentiate accurately between hemoglobin variants because of their reactions with
Hemoglobin S to clinically different diseases, allowing data to be displayed through chromatograms to represent a visual insight of elution of Hb O-Arab using retention time. to By using HPLC, it can accurately and reliable differentiate between Hemoglobin C and Hemoglobin O-Arab without any requirements for further confirmatory tests as stated by current CAP standards.
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who was asymptomatic and was referred because of contracting mild anaemia. The origins of all three offspring were from South Sudan, with all three suffering from microcytic anaemia, with an average of 67.2-79% of their
Hemoglobin, being Hemoglobin-O Arab. The peripheral blood smears of the tested patients displayed target cells, microcytosis, polychromasia and nucleated red blood cells. The basis drawn from these case reports is that Hemoglobin O-Arab is a rare, alternation of Hemoglobin, demonstrating effects similar to those diagnosed with mild to moderate microcytic anemia.
220:, by X-Ray Crystallography, earning his work with partner, John Kendrew the 1962 Nobel Prize in Chemistry, the molecular structure of hemoglobin O-Arab has not been obtained yet. The first sighted case of Hb O-Arab in combination with sickle hemoglobin was described in 1960 in an Arabic boy with severe hemolytic anaemia and recurrent painful episodes. Following cases of patients inheriting hetereozygotes for Hb O-Arab have been evident in the Middle Eastern descent, having clinical and laboratory manifestations characteristic of a sickling disease with hemolytic anaemia.
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Treatment and counselling offered, depending on different ages of contraction of Hb O-Arab and severity of inheritance of the alternation. Generalised, evolution of Hb O-Arab has long survival with no visual symptoms, but act as carriers of haemoglobin disorder. Thus, treatment can include screening
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Case reports analysed by Doctor Sayar Dror, PhD, at the
Paediatric Hemato-Oncology Unit, “Dana” Children Hospital in Israel, feature three patients; a 12 month-old female of consanguineous parents, a 35 month-old female born to parents known to have the Hemoglobin O-Arab trait, and a 9 month-old male
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When
Hemoglobin O-Arab co-inherits with Hemoglobin S, it produces a syndrome with similarities in severity to sickle cell anaemia, having severe haemolytic anaemia and red cells denser than normal with occurrences of some cells as dense as if contract with sickle cell anaemia. A description with the
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The most commonly used method for
Hemoglobin analysis used is alkaline cellulose acetate electrophoresis at pH 8.6, due to its ability to split hemoglobin into its common variants, however a review of the College of American Pathologists (CAP) Hemoglobinopahty Survey Reports has provided the number
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Another case study with data collection apparent for over 1,000 adults and paediatric patients followed by the Duke
University Comprehensive Sickle Cell Center was used to identify patients, reviewing age. Gender and race to record similarities in complications in each patient such as painful
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Joutovsky, Alla ; Nardi, Michael. April 2004. ‘Hemoglobin C and hemoglobin O-Arab variants can be diagnosed using the Bio-Rad
Variant II high-performance liquid chromatography system without further confirmatory test. Archives of Pathology & Laboratory Medicine, Vol.128(4),
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Nagel, Ronald L. ; Krishnamoorthy, Rajagopal ; Fattoum, Slaheddine ; Elion, Jacques ; Genard, Nathalie ; Romero, Jose ; Fabry, Mary E, December 1999. ‘The erythrocyte effects of haemoglobin O ARAB. British
Journal of Hematology, Vol.107(3),
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vaso-occlusive events, acute chest syndrome and leg ulcers. Out of the cohort tested, with
Hemoglobin O-Arab present, all patients shown a median Hemoglobin concentration of 8.7gm/dL, which is higher than the average concentration in a healthy being.
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known as Hemoglobin S/O-Arab. Detection of Hb O-Arab can be carried out with a blood test, identifying the carries of hemoglobinopathies, so as to inform patients their chances of producing an affected child and ensure appropriate guidance is given.
183:(American English) or Haemoglobin O-Arab (British English) is a rare alternation of Hemoglobin (American English) or Haemoglobin (British English), characterised with the presence of β^121Glu → Lys (Hb O-Arab). Mutations of
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Zimmerman, Sherri A.; O' Branski, Erin E.; Rosse, Wendell F.; Ware, Russell E. April 1999. ‘Hemoglobin S/O ARAB: Thirteen new cases and review of the literature. American Journal of Hematology, Vol.60(4),
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Dror, Sayar, March 2013. ‘Clinical and hematological features of homozygoushemoglobin O‐Arab . Pediatric Blood & Cancer, Vol.60(3), pp.506-507.
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for Hb O-Arab have been reported in Saudi Arabia, North Africa, Sudan, the Mediterranean and the United States. Diagnosis of Hb O-Arab requires
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and blood tests before coitus can detect any affected offspring, with provided genetic counselling and chances of producing affect offspring.
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Duran, M.; Comert, M.; Saydam, October 2014. G. Pp-070 hemoglobin-o arab in an asymptomatic patient. Leukemia Research, Vol.38, S1, p.S49.
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