358:
A control group was created that were subject to mechanical ventilation. Corosurf was found to reduce pulmonary air leaks and neonatal mortality in preterm infants. Halliday created further international clinical trials that led from single dose treatments that reduced mortality in the early 1980s from 50% to about 10% with multiple doses in the 1990s. In 1992, Halliday published the results of a large
Randomized European Multicentre trial that he coordinated and led that concluded that treatment with multiple doses of Curosurf surfactant is more effective than single-dose treatment in severe neonatal respiratory distress syndrome that further reduced
1211:
Boenisch, Herbert; Albrecht, Klaus; Hanssler, Ludwig; Haim, Michaela; Oetomo, Sidarto B.; Okken, Albert; Altfeld, Peter C.; Groneck, Peter; Kachel, Walter; Relier, Jean-Pierre; Walti, Herve (1 January 1992). "Randomized
European Multicenter Trial of Surfactant Replacement Therapy for Severe Neonatal Respiratory Distress Syndrome: Single Versus Multiple Doses of Curosurf".
326:. Morley analysed Halliday's results in a sub-group of infants of 25–29 weeks’ gestation in four trials and showed how that surfactant treated infants had lower death rates than if treated normally. As the control group was insufficiently large, Morley suggested to Halliday that he make contact with the Swedish physician
357:
The success of the 27-day experiment spurred
Halliday and Robertson to create the first international clinical trial for Corusurf. They selected a randomised group of preterm infants of around 10 hours old who were suffering from severe RDS who were given a single dose of Corosurf at 200 mg/kg.
1246:
Halliday, HL; Patterson, CC; Halahakoon, CW; European
Multicenter Steroid Study, Group (February 2001). "A multicenter, randomized open study of early corticosteroid treatment (OSECT) in preterm infants with respiratory illness: comparison of early and late treatment and of dexamethasone and inhaled
1210:
Speer, Christian P.; Robertson, Bengt; Curstedt, Tore; Halliday, Henry L.; Compagnone, Daniele; Gefeller, Olaf; Harms, Karsten; Herting, Egbert; McClure, Garth; Reid, Marc; Tubman, Richard; Herin, Peter; Noack, Gerd; Kok, Joke; Koppe, Janna; van
Sonderen, Loekie; Laufkötter, Edgar; Köhler, Wolfgang;
274:
Upon returning to
Belfast in 1979 he was appointed to the Royal Maternity Hospital as second consultant neonatologist. At the Royal Maternity, Halliday worked to develop a new neonatal unit and to expand neonatal care across the whole of Northern Ireland. While there, he worked with the
418:
In 1992 he was appointed
Honorary Professor in the Department of Child Health at Queen's University. In 1997 he appointed President of the European Society for Paediatric Research. In 2006 Halliday was appointed to the position of president of the
1139:
Noack, G.; Berggren, P.; Curstedt, T.; Grossmann, G.; Herin, P.; Mortensson, W.; Nilsson, R.; Robertson, B. (September 1987). "Severe
Neonatal Respiratory Distress Syndrome Treated with the Isolated Phospholipid Fraction of Natural Surfactant".
374:. In 2000, Halliday coordinated a large multicentre, randomized clinical trial of early corticosteroid treatment, known as OSSECT to compare whether there was any difference in early (<3 days) with late (>15 days) steroid therapy and
207:
for research into neonatology, for coordinating two of the largest neonatal multicentre trials for prevention and treatment of a number of neonatal respiratory illnesses and for a breakthrough in the development of a new
431:
In 2010 Halliday was awarded the
Maternité Prize from the European Society of Perinatal Medicine for his advocacy in international medical politics that led to structural reform. In 2021, Halliday was awarded the
782:
Halliday, Henry L.; Reid, Mark McC.; Meban, Cowan; Mcclure, Garth; Lappin, Terence R.J.; Thomas, Paul S. (March 1984). "Controlled Trial of
Artificial Surfactant to Prevent Respiratory Distress Syndrome".
303:
In 1984, Halliday held a randomised, controlled trial of an artificial surfactant known as the "Belfast surfactant" to test how effective it was on pre-term infants, for the treatment of RDS. The
191:
350:
where Turfsurf was compared to Curosurf. Curosurf was found to be superior. Halliday witnessed the highly efficacious Corusurf at work when pre-term twins were treated, who were going
224:
Halliday was one of four siblings, the eldest of four brothers. His father Louis Halliday was an accountant, while his mother Gladys was a shopkeeper. Halliday attended school at the
177:
1373:
1413:
1175:"Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group".
235:
In 1977, Halliday married Marjorie Dalziel who was an intensive care nurse. The couple had three children, Joy, Gail & Brian Joshua, all of whom became doctors.
247:
with a specialism in neonatal medicine. After his postgraduate training in Belfast, he moved to the United States where he spent three years, first working at the
318:
in a ratio of 10:1. However, the surfactant was never developed into a commercial product as the trial was disappointing. In the same year, Halliday met
621:
248:
102:
256:
184:
110:
1063:
Curstedt, Tore; Halliday, Henry L.; Speer, Christian P. (2015). "A Unique Story in Neonatal Research: The Development of a Porcine Surfactant".
499:
1661:
997:
Morley, C.J.; Miller, N.; Bangham, A.D.; Davis, J.A. (January 1981). "Dry Artificial Lung Surfactant and ITS Effect on Very Premature Babies".
1930:
903:
383:
20:
213:
1399:
584:
488:
1100:"Automated image analysis of alveolar expansion patterns in immature newborn rabbits treated with natural or artificial surfactant"
440:
for outstanding contributions to paediatric knowledge, Halliday was the first Northern Ireland physician to be awarded the medal.
40:
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153:
420:
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was largely a disappointment as he realised his artificial surfactant wasn't a good substitute for the natural surfactant.
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161:
98:
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622:"Professor Henry Halliday, paediatrician who vastly improved the survival prospects of very premature babies – obituary"
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1608:
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Halliday's other area of interest was in the use of postnatal steroids (inhaled and systemic) to prevent chronic
157:
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315:
292:
280:
1768:
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Speer, Christian P.; Curstedt, Tore; Saugstad, Ola D. (22 December 2022). "Henry L. Halliday (1945–2022)".
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had created Curosurf from pig lungs instead of cow lungs. Halliday spent a month with Robertson at the
500:"Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations With Neonatal Anthropometrics"
1925:
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264:
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in the face due to a lack of oxygen and almost immediately after treatment, turning a healthy pink.
319:
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371:
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950:"Surfactant Therapy for Respiratory Distress Syndrome in Premature Neonates: A Comparative Review"
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284:
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1423:
1022:
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874:
808:
687:
433:
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288:
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585:"Professor Emeritus Henry Halliday is first in NI to be awarded prestigious James Spence Medal"
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756:
19:
This article is about the British paediatrician. For the cricketer who was born in 1855, see
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Halliday's product was a synthetic lung surfactant called Turfsurf and was a mixture of
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Halliday, Henry L.; McClure, Garth; Reid, Mark; Bell, Angela; Tubman, Richard (1998).
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at Queens University with a paper on the role of left to right shunting through a
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Halliday, H; Robertson, B; Nilsson, R; Rigaut, JP; Grossmann, G (October 1987).
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in Stockholm in November 1984, when they ran a 27 day pre-clinical trial both
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who had also developed a surfactant Poractant alfa known under the trade name
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39:
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804:
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757:"Assessment of left-to-right shunt in neonatal patient ductus arteriosus"
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343:
1374:"Tributes to prominent neonatologist who conducted pioneering research"
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in the foetus and neonate and long term follow-up of survivors of CLD.
63:
1076:
861:
845:"The fascinating story of surfactant: Fascinating story of surfactant"
844:
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515:
463:
402:
In 2004, Halliday along with his colleague, the German paediatrician
895:
Suffer the Little Children?: A Personal History of Newborn Medicine
386:. The study found no difference. He also conducted research on the
322:
who had developed a synthetic lung surfactant known as "ALEC" with
259:
in San Francisco. In San Francisco, Halliday met the influential
1395:
450:
Halliday, Henry L. (2005). "History of Surfactant from 1980".
228:
before deciding to study medicine. He matriculated in 1965 at
406:
co-founded the journal "Biology of the Neonate" now known as
1042:"Tore Curstedt's Curosurf helped millions of preterm babies"
948:
Ainsworth, Sean B.; Milligan, David W. A. (December 2002).
195:(29 November 1945 – 12 November 2022) was a British-Irish
498:
HAPO Study Cooperative Research Group (1 February 2009).
1044:. Karolinska Institutet. News from Karolinska Institutet
212:
that brought relief to very small babies suffering from
267:
who stimulated his interest in surfactant research and
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and later at the Cardiovascular Research Institute,
44:
Halliday at his acceptance of the James Spence Medal
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382:treatment in preterm infants at risk of developing
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135:
116:
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86:
70:
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30:
1353:. European Association of Perinatal Medicine. 2015
926:. The Woodlands, Texas: American Pediatric Society
124:that enabled very small babies to breath properly
1040:Heijbel, Matts; Betteridge, Neil (9 June 2016).
1407:
1372:McConville, Marie Louise (17 November 2022).
560:Royal College of Paediatrics and Child Health
510:(2). American Diabetes Association: 453–459.
8:
1327:. European Association of Perinatal Medicine
1414:
1400:
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421:European Association of Perinatal Medicine
27:
1115:
1104:British Journal of Experimental Pathology
965:
898:. Troubador Publishing Ltd. p. 309.
860:
666:British Association of Perinatal Medicine
591:. Queens University Belfast. 21 July 2021
523:
954:American Journal of Respiratory Medicine
346:and in rabbit fetus's ventilated with a
249:Rainbow Babies & Children's Hospital
103:Rainbow Babies & Children's Hospital
943:
941:
849:Journal of Paediatrics and Child Health
547:
483:(4th ed.). London: W.B. Saunders.
243:Halliday decided to pursue a career in
111:University of California, San Francisco
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232:medical school and graduated in 1970.
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21:Harry Halliday (cricketer, born 1855)
7:
1376:. The Irish News Ltd. The Irish News
662:"Obituary: Professor Henry Halliday"
390:of CLD and inflammation, as well as
214:infant respiratory distress syndrome
203:. In 2021, Halliday was awarded the
1325:About Us - Previous EAPM presidents
481:Handbook of neonatal intensive care
1154:10.1111/j.1651-2227.1987.tb10552.x
14:
660:Sweet, David (23 November 2022).
16:British neonatologist (1945–2022)
892:Levene, Malcolm (28 July 2021).
843:Halliday, Henry L (April 2017).
154:Royal Jubilee Maternity Hospital
38:
1347:"Erich Saling Maternity Prize"
438:British Paediatric Association
340:Karolinska University Hospital
334:. Robertson and his colleague
312:Dipalmitoylphosphatidylcholine
1:
1656:Richard Worthington Smithells
1615:Frederick John William Miller
1544:Seymour Donald Mayneord Court
1011:10.1016/s0140-6736(81)90002-7
920:"Henry Lewis Halliday – 2022"
797:10.1016/s0140-6736(84)92849-6
283:along with the obstetrician,
1931:Medical doctors from Belfast
1183:(5): 683–91. November 1988.
688:"Prof Henry Lewis HALLIDAY"
1952:
1538:Ronald Stanley Illingworth
1467:Robert Royston Amos Coombs
1321:"Previous EAPM presidents"
556:"Professor Henry Halliday"
230:Queen's University Belfast
162:Queen's University Belfast
99:Queen's University Belfast
18:
366:Use of postnatal steroids
316:high-density lipoproteins
287:. In 1980, he passed the
167:
158:Mater Infirmorum Hospital
128:
37:
293:patent ductus arteriosus
257:University of California
1769:Jonathan Richard Sibert
1603:John Peter Mills Tizard
1514:Ronald Charles MacKeith
1455:Lionel Sharples Penrose
1449:Frank Macfarlane Burnet
1936:British paediatricians
1627:David Cornelius Morley
1591:James W. Bruce Douglas
1567:James Mourilyan Tanner
1309:. Basel: S. Karger AG.
1261:10.1542/peds.107.2.232
299:Surfactant development
1668:Osmund Royle Reynolds
1550:Kenneth William Cross
1502:Douglas Vernon Hubble
1438:Alan Moncrieff (1960)
1189:10.1542/peds.82.5.683
226:Belfast Royal Academy
1828:Albert Aynsley-Green
1225:10.1542/peds.89.1.13
384:chronic lung disease
265:pulmonary surfactant
174:Henry Lewis Halliday
122:pulmonary surfactant
1674:Richard H. R. White
1585:John Oldroyd Forfar
1520:Cyril Astley Clarke
1479:Donald W. Winnicott
261:John Allen Clements
1846:Terence Stephenson
1692:Forrester Cockburn
1621:Otto Herbert Wolff
1597:Neil Simson Gordon
1526:Edward John Bowlby
1424:James Spence Medal
1422:Recipients of the
1303:"Neonatology News"
1287:has generic name (
967:10.1007/BF03257169
628:. 24 November 2022
434:James Spence Medal
427:Awards and honours
404:Christian P. Speer
263:, a specialist in
205:James Spence Medal
1908:
1907:
1739:Catherine Peckham
1644:Leonard B. Strang
1485:Geoffrey S. Dawes
1077:10.1159/000381117
905:978-1-80046-646-3
862:10.1111/jpc.13500
791:(8375): 476–478.
763:. British Library
734:10.1159/000528598
516:10.2337/db08-1112
464:10.1159/000084879
171:
170:
130:Scientific career
1943:
1816:Anthony Costello
1810:Andrew Wilkinson
1650:John Allen Davis
1609:John Lewis Emery
1579:Dermod MacCarthy
1532:Douglas Gairdner
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74:12 November 2022
60:29 November 1945
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1822:Sheila Shribman
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1775:Victor Dubowitz
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1005:(8211): 64–68.
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328:Bengt Robertson
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210:lung surfactant
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1899:Andrew Pollard
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1887:Henry Halliday
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1852:Anne Greenough
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1148:(5): 697–705.
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1090:
1071:(4): 321–329.
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1032:
989:
960:(6): 417–433.
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911:
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884:
855:(4): 327–332.
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562:. 21 July 2021
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458:(4): 317–322.
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348:plethysmograph
320:Colin J Morley
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78:(aged 76)
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32:Henry Halliday
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1065:Neonatology
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930:13 December
924:In Memoriam
767:10 February
722:Neonatology
698:13 December
452:Neonatology
408:Neonatology
269:pulmonology
245:paediatrics
144:neonatology
87:Nationality
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1864:Alan Emond
1781:Alan Craft
1763:Alan Lucas
1745:David Hall
1704:Roy Meadow
1680:David Hull
1662:June Lloyd
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1177:Pediatrics
999:The Lancet
785:The Lancet
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632:7 December
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566:7 December
542:References
398:Publishing
380:budesonide
140:Pediatrics
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694:. Belfast
414:Societies
289:MD Thesis
281:Mark Reid
253:Cleveland
107:Cleveland
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