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Straub, Isabelle; KrĂźgel, Ute; Mohr, Florian; Teichert, Jens; Rizun, Oleksandr; Konrad, Maik; Oberwinkler, Johannes; Schaefer, Michael (November 2013). "Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo".
614:, hesperetin â as for all flavonoids â is rapidly metabolized in intestinal and liver cells, releasing smaller metabolites into the blood and urine for excretion. The biological effects of such metabolites
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587:
384:
633:, hesperetin may affect the slow inactivation phase of inward sodium current channels, and therefore could be used as a template to develop drugs against
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756:"The citrus flavanone hesperetin preferentially inhibits slowâinactivating currents of a long QT syndrome type 3 syndrome Na channel mutation"
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707:"Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid"
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AlvarezâCollazo, Julio; LĂłpezâRequena, Alejandro; GalĂĄn, Loipa; Talavera, Ariel; Alvarez, Julio L.; Talavera, Karel (27 March 2019).
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InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
313:
368:
InChI=1/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
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559:-rutinoside), a water-insoluble flavonoid glycoside with low water solubility, Hesperidin is found in
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Except where otherwise noted, data are given for materials in their
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68:)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4
694:. PubChem, US National Library of Medicine. 4 May 2024.
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453:226â228 °C (439â442 °F; 499â501 K)
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563:fruits and upon ingestion it releases its
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53:)-3â˛,5,7-Trihydroxy-4â˛-methoxyflavan-4-one
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602:is an enzyme that uses hesperidin and H
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392:O=C2c3c(O(c1ccc(OC)c(O)c1)C2)cc(O)cc3O
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361:Key: AIONOLUJZLIMTK-AWEZNQCLSA-N
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705:Majumdar S.; Srirangam, R. (2009).
551:of hesperetin are known, including
371:Key: AIONOLUJZLIMTK-AWEZNQCLBH
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1031:(Narigenin 7-O-neohesperidoside)
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515:is the 4'-methoxy derivative of
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760:British Journal of Pharmacology
474:(at 25 °C , 100 kPa).
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1120:Flavonoids found in Rutaceae
606:O to produce hesperetin and
1037:(Naringenin 7-O-rutinoside)
966:(Pinocembrin-7-methylether)
637:. Hesperetin also inhibits
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1048:(Naringenin-7-O-glucoside)
527:-glycoside of hesperetin,
723:10.1007/s11095-008-9729-6
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610:. Upon digestion in the
1115:O-methylated flavanones
984:C-methylated flavanones
936:O-methylated flavanones
818:10.1124/mol.113.086843
806:Molecular Pharmacology
612:gastrointestinal tract
1087:Acetylated glycosides
893:Flavanones and their
539:, and sweet oranges.
60:Systematic IUPAC name
859:at Wikimedia Commons
635:cardiac arrhythmias
624:Laboratory research
464:Sol. EtOH, alkalis
443: g¡mol
72:-1-benzopyran-4-one
18:
1078:Sophoraflavanone G
1068:8-Prenylnaringenin
501:Infobox references
461:in other solvents
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855:Media related to
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596:-rhamnosyl-β-
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588:Hesperidin 6-
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569:Neohesperidin
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692:"Hesperetin"
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674:. Retrieved
670:"Flavonoids"
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628:
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600:-glucosidase
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160:ChEMBL399121
79:Identifiers
69:
65:
50:
970:Sakuranetin
964:Pinostrobin
926:Pinocembrin
916:Eriodictyol
533:grapefruits
517:eriodictyol
401:Properties
218:100.007.538
140:CHEBI:28230
17:Hesperetin
1109:Categories
1061:Acetylated
1024:Liquiritin
1019:Hesperidin
1009:Eriocitrin
1001:Glycosides
949:Hesperetin
921:Naringenin
903:Flavanones
895:glycosides
857:Hesperetin
711:Pharm. Res
649:References
583:Metabolism
553:hesperidin
549:glycosides
543:Glycosides
529:hesperidin
513:Hesperetin
459:Solubility
436:Molar mass
302:Q9Q3D557F1
171:ChemSpider
107:3D model (
86:CAS Number
46:IUPAC name
1052:Sakuranin
1035:Narirutin
944:Alpinetin
826:1521-0111
641:channels
571:is the 7-
521:flavanone
239:208-290-2
231:EC Number
1041:Poncirin
1029:Naringin
975:Sterubin
834:24006495
790:30650182
741:18810327
643:in vitro
630:In vitro
608:rutinose
565:aglycone
547:Various
523:. The 7-
191:DrugBank
96:520-33-2
1094:Nirurin
781:6451064
732:2664388
617:in vivo
494:what is
492: (
441:302.282
269:PubChem
200:DB01094
1046:Prunin
991:Poriol
832:
824:
788:
778:
739:
729:
676:10 May
561:citrus
537:lemons
489:verify
486:
385:SMILES
257:C01709
151:ChEMBL
40:Names
911:Butin
639:TRPM3
350:InChI
282:72281
180:65234
131:ChEBI
109:JSmol
830:PMID
822:ISSN
786:PMID
737:PMID
678:2024
519:, a
293:UNII
248:KEGG
814:doi
776:PMC
768:doi
764:176
727:PMC
719:doi
592:-Îą-
319:EPA
272:CID
1111::
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604:2
598:D
594:L
590:O
575:-
573:O
557:O
525:O
484:Y
429:6
426:O
420:H
414:C
321:)
317:(
111:)
70:H
66:S
51:S
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