327:
70:
42:
419:
238:
can be classified into eight different genotypes from different geographical regions: genotype 1 (Asia), genotype 2 (Africa and Mexico), genotype 3 (Europe and North
America), genotype 4 (Asia); genotypes 5 and 6 have been detected in Asian wild boar and genotypes 7 and 8 in camels.
399:
The strains of HEV that exist today may have arisen from a shared ancestor virus 536 to 1344 years ago. Another analysis has dated the origin of
Hepatitis E to ~6000 years ago, with a suggestion that this was associated with domestication of pigs. At some point, two
226:
Globally, approximately 939 million corresponding to 1 in 8 individuals have ever experienced HEV infection. About 15–110 million individuals have recent or ongoing HEV infection. The virus particle was first seen in 1983, but was only molecularly cloned in 1989.
250:(ORF1, ORF2 and ORF3) encode for three proteins (O1, O2, O3), two of which are polyproteins, that is, they are cleaved into fragments which carry out the actual functions of the virus (see figure). The
407:
Whereas genotype 2 remains less commonly detected than other genotypes, genetic evolutionary analyses suggest that genotypes 1, 3, and 4 have spread substantially during the past 100 years.
1645:
345:
proteins has been mapped by
Osterman et al. (2015), who found 25 interactions among the 10 proteins studied. Almost all (24) of these interactions were considered as of "high quality".
326:
1068:
995:
2152:
2165:
1659:
960:
Mirazo S, Mir D, Bello G, Ramos N, Musto H, Arbiza J (2016). "New insights into the hepatitis E virus genotype 3 phylodynamics and evolutionary history".
1325:
404:
may have diverged — an anthropotropic form and an enzootic form — which subsequently evolved into genotypes 1 and 2 and genotypes 3 and 4, respectively.
1156:
641:
Balayan MS, Andjaparidze AG, Savinskaya SS, et al. (1983). "Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route".
1196:
676:
Reyes GR, Purdy MA, Kim JP, et al. (1990). "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis".
1061:
1289:
1346:
1665:
1191:
1148:
1580:
1651:
1054:
49:
1250:
1236:
1040:"Virus Pathogen Database and Analysis Resource (ViPR) – Hepeviridae – Genome database with visualization and analysis tools"
69:
1455:
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1360:
1354:
1244:
295:
1818:
1744:
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1411:
2170:
1875:
1482:
777:
Osterman A, Stellberger T, Gebhardt A, Kurz M, Friedel CC, Uetz P, Nitschko H, Baiker A, Vizoso-Pinto MG (2015).
718:
Schlauder, G. G. & Mushahwar, I. K. (2001) Genetic heterogeneity of hepatitis E virus. J Med Virol 65, 282–92
1008:
Izopet J, Abravanel F, Dalton H, Nassim RK (2014) Hepatitis E Virus
Infection. Clin Micro Reviews 27 (1) 116–138
2198:
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511:
901:
Baha, Sarra; Behloul, Nouredine; Liu, Zhenzhen; Wei, Wenjuan; Shi, Ruihua; Meng, Jihong (2019-10-29).
2193:
2023:
1855:
1490:
1319:
847:
790:
685:
271:
64:
1441:
1162:
1544:
1300:
587:
Li P, Liu J, Li Y, Su J, Ma Z, Bramer WM, Cao W, de Man RA, Peppelenbosch MP, Pan Q (July 2020).
247:
189:
1046:
2157:
589:"The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis"
2111:
2008:
1959:
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protein encodes the capsid, which is composed of three domains, namely the shell domain (
851:
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878:
835:
811:
778:
754:
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903:"Comprehensive analysis of genetic and evolutionary features of the hepatitis E virus"
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domain is a fusion protein consisting of the Plp, V, and X domains. The
287:
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802:
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418:
1394:
401:
372:
2058:
836:"Evolutionary History and Population Dynamics of Hepatitis E Virus"
2045:
1804:
1436:
81:
322:). Numbers in the figure indicate positions in the RNA sequence.
2062:
1050:
570:"Hepeviridae - Hepeviridae - Positive-sense RNA Viruses - ICTV"
1271:
306:
protein is encoded by a single open-reading frame (ORF3). The
243:
834:
Khudyakov, Yury E.; Purdy, Michael A. (17 December 2010).
1022:"Hepeviridae – Hepeviridae – Positive-sense RNA Viruses"
242:
The viral genome is a single strand of positive-sense
523:
International
Committee on Taxonomy of Viruses (ICTV)
2127:
2071:
2022:
1998:
1906:
1829:
1784:
1773:
1602:
1564:
1543:
1511:
1466:
1420:
1299:
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1261:
1088:
254:protein consists of seven such fragments, namely
379:. It is now classified as a member of the genus
779:"The Hepatitis E virus intraviral interactome"
505:
503:
501:
246:that is about 7200 bases in length. The three
1062:
8:
994:: CS1 maint: multiple names: authors list (
564:
562:
560:
558:
510:Purdy, Michael A.; et al. (June 2014).
365:It was previously classified in the family
2059:
1781:
1561:
1326:Progressive multifocal leukoencephalopathy
1296:
1069:
1055:
1047:
40:
29:
1197:Extranodal NK/T-cell lymphoma, nasal type
1031:at the U.S. National Library of Medicine
936:
918:
877:
859:
810:
753:
730:"Molecular virology of hepatitis E virus"
614:
604:
497:
474:
987:
7:
728:Ahmad I, Holla RP, Jameel S (2011).
636:
634:
1347:Subacute sclerosing panencephalitis
357:in diameter and are not enveloped.
25:
1666:Severe acute respiratory syndrome
1192:Follicular dendritic cell sarcoma
353:The viral particles are 27 to 34
1652:Middle East respiratory syndrome
417:
325:
278:(proline-rich variable region),
68:
512:"New Classification Scheme for
1251:Adult T-cell leukemia/lymphoma
1237:Splenic marginal zone lymphoma
746:10.1016/j.virusres.2011.02.011
314:) and two protruding domains (
1:
1456:Tropical spastic paraparesis
1361:Lymphocytic choriomeningitis
974:10.1016/j.meegid.2016.06.003
861:10.1371/journal.pone.0014376
481:The former species name was
296:RNA-dependent RNA polymerase
216:) is the causative agent of
1819:Cytomegalovirus esophagitis
1739:Human parainfluenza viruses
1412:Ramsay Hunt syndrome type 2
2215:
282:(X-domain, macro-domain),
1483:Cytomegalovirus retinitis
920:10.1186/s12864-019-6100-8
195:
188:
63:
48:
39:
32:
1585:Infectious mononucleosis
1402:Chandipura vesiculovirus
1232:Hepatocellular carcinoma
1177:Nasopharyngeal carcinoma
1110:Hepatocellular carcinoma
1033:Medical Subject Headings
1381:Encephalitis lethargica
1082:viral systemic diseases
698:10.1126/science.2107574
544:Avian hepatitis E virus
375:more closely resembles
220:. It is of the species
1753:Human orthopneumovirus
1407:Herpesviral meningitis
1368:Arbovirus encephalitis
1211:Merkel-cell carcinoma
1856:Adenovirus infection
1320:Human polyomavirus 2
1149:Oropharyngeal cancer
337:The protein-protein
272:papain-like protease
65:Virus classification
1442:Post-polio syndrome
1078:Infectious diseases
852:2010PLoSO...514376P
795:2015NatSR...513872O
690:1990Sci...247.1335R
593:Liver International
248:open reading frames
231:Genome and proteome
1575:Epstein–Barr virus
1545:Respiratory system
1182:Burkitt's lymphoma
542:, and the species
2181:
2180:
2129:Hepatitis E virus
2065:Taxon identifiers
2056:
2055:
2018:
2017:
1769:
1768:
1700:Influenza virus A
1617:Human coronavirus
1507:
1506:
1497:Herpes of the eye
1029:Hepatitis+E+virus
962:Infect Genet Evol
803:10.1038/srep13872
655:10.1159/000149370
606:10.1111/liv.14468
536:Hepatitis E virus
483:Hepatitis E virus
452:Hepatitis C virus
442:Hepatitis B virus
260:methyltransferase
222:Orthohepevirus A.
210:hepatitis E virus
206:
205:
199:Hepatitis E virus
18:Hepatitis e virus
16:(Redirected from
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2103:Orthohepevirus A
2092:
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2073:Orthohepevirus A
2060:
1782:
1777:digestive system
1694:Orthomyxoviridae
1660:SARS coronavirus
1646:MERS coronavirus
1562:
1374:Orthomyxoviridae
1297:
1263:Immune disorders
1187:Hodgkin lymphoma
1163:Kaposi's sarcoma
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684:(4948): 1335–9.
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599:(7): 1516–1528.
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548:Orthohepevirus B
546:will be renamed
540:Orthohepevirus A
538:will be renamed
531:
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343:Orthohepevirus A
329:
236:Orthohepevirus A
181:Orthohepevirus A
73:
72:
57:Orthohepevirus A
44:
34:Orthohepevirus A
30:
27:Species of virus
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2199:Viral hepatitis
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1876:Gastroenteritis
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1831:Gastroenteritis
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1813:Cytomegalovirus
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1733:Paramyxoviridae
1722:Avian influenza
1598:
1593:Cytomegalovirus
1557:viral pneumonia
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1477:Cytomegalovirus
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144:Hepelivirales
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132:Alsuviricetes
129:
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1301:Encephalitis
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990:cite journal
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534:The species
533:
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78:(unranked):
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2194:Hepeviridae
2097:Wikispecies
1897:Coronavirus
1638:Common cold
1550:acute viral
1533:Myocarditis
1377:(probable)
1129:Anal cancer
514:Hepeviridae
463:Hepatitis E
458:Hepatitis D
448:Hepatitis C
438:Hepatitis B
433:Hepatitis A
388:Hepeviridae
339:interactome
333:Interactome
218:hepatitis E
156:Hepeviridae
2188:Categories
2024:Urogenital
1890:Astrovirus
1850:Adenovirus
1674:SARS-CoV-2
1431:Poliovirus
1306:meningitis
968:: 267–73.
913:(1): 790.
493:References
355:nanometers
53:micrograph
2088:Q24757533
1935:RNA virus
1916:DNA virus
1908:Hepatitis
1883:Norovirus
1871:Rotavirus
1865:RNA virus
1844:DNA virus
1790:Esophagus
1718:Influenza
1604:RNA virus
1566:DNA virus
1335:RNA virus
1314:DNA virus
1220:RNA virus
1098:DNA virus
1090:Oncovirus
929:1471-2164
870:1932-6203
789:: 13872.
734:Virus Res
395:Evolution
349:Structure
175:Species:
103:Kingdom:
96:Riboviria
2158:11459945
2144:Q5731737
2138:Wikidata
2082:Wikidata
2033:BK virus
1836:diarrhea
1680:COVID-19
1422:Myelitis
982:27264728
947:31664890
888:21203540
840:PLOS ONE
821:26463011
764:21345356
625:32281721
411:See also
361:Taxonomy
288:helicase
190:Synonyms
151:Family:
115:Phylum:
59:virions
1786:Pharynx
1290:Central
938:6820953
879:3006657
848:Bibcode
812:4604457
791:Bibcode
783:Sci Rep
755:3130092
706:2107574
686:Bibcode
678:Science
663:6409836
616:7384095
298:). The
290:), and
163:Genus:
139:Order:
127:Class:
1450:HTLV-I
1395:Rabies
1245:HTLV-I
1035:(MeSH)
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373:genome
341:among
2171:12461
2153:IRMNG
2117:74WLY
2046:Mumps
1805:Mumps
1775:Human
1205:MCPyV
528:1 May
519:(PDF)
469:Notes
89:Realm
82:Virus
2166:NCBI
1760:hMPV
1632:OC43
1628:HKU1
1624:NL63
1620:229E
1278:AIDS
1157:KSHV
996:link
978:PMID
943:PMID
925:ISSN
884:PMID
866:ISSN
817:PMID
760:PMID
702:PMID
659:PMID
621:PMID
530:2019
292:Rdrp
208:The
2112:CoL
2040:MuV
2009:CBV
1984:HEV
1972:HDV
1960:HCV
1948:HAV
1941:CBV
1922:HBV
1799:MuV
1730:V,
1522:CBV
1491:HSV
1468:Eye
1355:LCV
1341:MeV
1272:HIV
1226:HCV
1171:EBV
1118:HPV
1104:HBV
970:doi
933:PMC
915:doi
874:PMC
856:doi
807:PMC
799:doi
750:PMC
742:doi
738:161
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611:PMC
601:doi
300:Pvx
284:Hel
274:),
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262:),
256:Met
244:RNA
214:HEV
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