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Howell–Jolly bodies are seen with markedly decreased splenic function. Common causes include asplenia (post-splenectomy) or congenital absence of spleen (right atrial appendage isomerism). Spleens are also removed for therapeutic purposes in conditions like
74:, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of Howell–Jolly bodies usually signifies a damaged or absent spleen, because a healthy spleen would normally filter such erythrocytes.
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Howell–Jolly bodies: small, round inclusions seen in erythrocytes (peripheral blood – MGG stain)
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261:(in French). Vol. 58. Paris: Comptes rendus de la Société de Biologie. pp. 528–531.
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198:"The life-history of the formed elements of the blood, especially the red blood corpuscles"
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Howell–Jolly bodies inside of two normoblasts (center) in bone marrow. Giemsa stain, 1000x.
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during erythrocyte circulation, but will persist in individuals with functional
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This DNA appears as a basophilic (purple) spot on the otherwise
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Recherches sur la formation des globules rouges des mammifères
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179:(MDS). The bodies can also can be seen in premature infants.
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blood smear. These inclusions are normally removed by the
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Digital
Pathology, Brown University: Howell-Jolly Bodies
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690:Abnormal clinical and laboratory findings for RBCs
146:involving the spleen, such as that used to treat
40:A Howell–Jolly body (marked by arrow) within an
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163:Howell–Jolly bodies are also seen in
77:The Howell–Jolly body is named after
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105:(pink) erythrocyte on a standard
32:Howell-Jolly body-like inclusions
27:Cluster of DNA in red blood cells
175:, hereditary spherocytosis, and
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134:, trauma to the spleen, and
70:. During maturation in the
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29:
602:Hypersegmented neutrophil
509:Hemoglobin precipitation
439:Hereditary stomatocytosis
385:Hereditary elliptocytosis
634:Critical green inclusion
425:Sickle cell/drepanocyte
397:Hereditary spherocytosis
177:myelodysplastic syndrome
132:hereditary spherocytosis
366:Membrane abnormalities
217:10.1002/jmor.1050040105
211:(1). New York: 57–116.
536:Red cell agglutination
196:Howell, W. H. (1890).
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62:remnants (clusters of
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205:Journal of Morphology
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639:Alder–Reilly anomaly
493:Basophilic stippling
173:megaloblastic anemia
79:William Henry Howell
614:Pelger–Huët anomaly
572:Reactive lymphocyte
498:Pappenheimer bodies
429:Sickle cell disease
142:. Other causes are
462:Hypochromic anemia
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140:sickle cell anemia
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83:Justin Marie Jolly
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629:Toxic vacuolation
624:Toxic granulation
555:White blood cells
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488:Howell–Jolly body
255:Jolly, J (1908).
144:radiation therapy
66:) in circulating
49:Howell–Jolly body
18:Howell-Jolly body
16:(Redirected from
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644:Jordans' anomaly
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477:Inclusion bodies
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169:hemolytic anemia
148:Hodgkin lymphoma
53:cytopathological
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321:Red blood cells
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107:H&E stained
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362:Poikilocytosis
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244:Who Named It?
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619:Döhle bodies
607:Arneth count
594:Granulocytes
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457:Anisochromia
435:Stomatocyte
346:Microcytosis
341:Macrocytosis
336:Anisocytosis
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103:eosinophilic
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68:erythrocytes
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577:Smudge cell
564:Lymphocytes
503:Cabot rings
416:Schistocyte
380:Elliptocyte
370:Acanthocyte
165:amyloidosis
115:hyposplenia
72:bone marrow
55:finding of
42:erythrocyte
649:Left shift
531:Haemoconia
513:Heinz body
411:Echinocyte
392:Spherocyte
312:Blood film
183:References
138:caused by
89:Appearance
57:basophilic
30:See also:
421:Degmacyte
406:Dacrocyte
239:synd/1596
167:, severe
684:Category
665:Auer rod
541:Rouleaux
375:Codocyte
314:findings
225:85700639
119:asplenia
60:nuclear
450:Colour
223:
125:Causes
111:spleen
658:Other
524:Other
355:Shape
221:S2CID
201:(PDF)
51:is a
329:Size
81:and
242:at
213:doi
117:or
64:DNA
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203:.
171:,
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121:.
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47:A
304:e
297:t
290:v
227:.
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209:4
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
