256:
233:
130:
155:
521:
514:
507:
262:
161:
1367:
function in frog embryos and human embryonic stem cells. Ablation of the ID gene family mouse embryos showed failure of anterior cardiac progenitor specification and the development of heartless embryos. This study also demonstrated that ID4 protein is involved in the regulating cardiac cell fate by
3166:
Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu YZ, Raval A, Liu TH, Ding W, Mao C, Liu S, Smith LT, Lee S, Rassenti L, Marcucci G, Byrd J, Caligiuri MA, Plass C (2005). "Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human
1740:
The ID4 gene is also known as DNA-binding protein inhibitor ID-4, Id-4, IDb4, IDB4, Inhibitor of DNA binding 4, Inhibitor of differentiation 4, helix protein 271, Inhibitor of DNA binding 4 HLH Protein, Inhibitor of
Differentiation 4, Inhibitor of DNA Binding 4 Dominant Negative Helix-Loop-Helix
1968:"Mutually exclusive expression of two dominant-negative helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing brain of the mouse suggests distinct regulatory roles of these dnHLH proteins during cellular proliferation and differentiation of the nervous system"
2368:
Bellido M, Aventín A, Lasa A, Estivill C, Carnicer MJ, Pons C, Matías-Guiu X, Bordes R, Baiget M, Sierra J, Nomdedéu JF (September 2003). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia".
2870:
Stewart HJ, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave KA, Mirsky R, Jessen KR (1998). "Helix-loop-helix proteins in
Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development".
3031:
Bellido M, Aventín A, Lasa A, Estivill C, Carnicer MJ, Pons C, Matías-Guiu X, Bordes R, Baiget M, Sierra J, Nomdedéu JF (2004). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia".
1479:
cell lines. The mechanism behind this is believed to be that ID4 regulates HOXA9 and CDKN1A genes, which are mediators of cell proliferation and differentiation. HOXA genes are known to play a role in the differentiation of fallopian tubes,
3411:
1192:
The ID4 gene is part of the ID gene family. This family is also known as inhibitors of DNA binding protein family and are composed of transcription inhibitory proteins which modulate a number of processes. They are
1726:
disorder. It is often identified after six to eight months of age in females. In human brain tissue specimens of Rett syndrome patients, the family of ID genes are seen to be significantly increased in expression.
1423:
revealed over 100 candidate genes associated with endometriosis. Of these, six were shown to have a highly reliable association, of which the ID4 gene was identified. This is thought to be due to an independent
3404:
4333:
2396:
Russell LJ, Akasaka T, Majid A, Sugimoto KJ, Loraine Karran E, Nagel I, Harder L, Claviez A, Gesk S, Moorman AV, Ross F, Mazzullo H, Strefford JC, Siebert R, Dyer MJ, Harrison CJ (Jan 2008).
8823:
3397:
4832:
1848:
Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22".
1124:. In humans, it encodes the protein known as DNA-binding protein inhibitor ID-4. This protein is known to be involved in the regulation of many cellular processes during both
7039:
1436:
6p22.3. ID4 is implicated in the molecular pathogenicity of endometriosis as being differentially expressed between the proliferative, early and mid-secretory phases.
5717:
4739:
4734:
4729:
269:
168:
4378:
4363:
4049:
2455:
Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T (December 2007).
4872:
8667:
8651:
3470:
8836:
4724:
1353:. This is integral to normal brain size formation. ID4 regulates neural progenitor proliferation and differentiation. Its expression is seen in the
854:
835:
91:
4509:
4502:
4497:
4485:
4480:
4475:
4470:
4465:
4393:
8389:
5188:
4247:
1636:
bladder cancer. ID4 has also been shown to be overexpressed in bladder cancer cell lines. This overexpression is equally seen in both normal
1830:
1812:
8856:
1218:
containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems.
255:
8152:
4044:
3616:
2884:
8421:
7320:
5407:
2111:
2094:
1681:. There is an undefined but significant association seen in ID4 promoter hypermethylation (which results in its down regulation) and
1611:
carcinomas also show ID4 expression. There is a hypothesis that ID4 acts as a tumour suppressor factory in human breast tissue where
1061:
1054:
232:
4865:
4860:
4788:
4778:
3655:
3645:
3480:
2496:
Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA (April 2005).
1273:
ID4 expression has been shown to be discrete in the early stages, with transcription transiently expressed in subsets of migrating
4783:
4697:
1886:
1750:
1184:
motif from amino acid 65 to 105 and a poly-Pro region from amino acid 118 to 124. This protein is expressed in various tissues.
7719:
4995:
4985:
3586:
3465:
2398:"t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)"
1799:
1778:
1296:
3251:"Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome"
2943:
Beger C, Pierce LN, Kruger M, Marcusson EG, Robbins JM, Welcsh P, Welch PJ, Welte K, King MC, Barber JR, Wong-Staal F (2001).
8861:
5350:
4990:
4685:
1967:
1425:
1795:
2775:"Inhibitors of differentiation (ID1, ID2, ID3, ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome"
154:
129:
8632:
8627:
7778:
4690:
2829:"E2A basic helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein"
1502:
1420:
1774:
1230:(antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the
8727:
7063:
5213:
4766:
4756:
3133:"Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis"
1270:. ID4 transcription control has both negative and positive regulatory elements inclusive of novel inhibitory functions.
71:
20:
3090:"Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas"
2457:"Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche"
7232:
7227:
6778:
4855:
4773:
4761:
3837:
2945:"Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach"
2095:"Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis"
1919:"The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3"
2998:"Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation"
2002:"A role for Sp and helix-loop-helix transcription factors in the regulation of the human Id4 gene promoter activity"
4968:
3966:
2734:"Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer"
1507:
1194:
268:
167:
8384:
5265:
5250:
5233:
5228:
5223:
5218:
5129:
5104:
4980:
4892:
4882:
4039:
3512:
1267:
3329:"Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer"
1698:. Hypermethylation of ID4 causes silencing of the gene. This has been identified as a significant independent
1337:
proliferation and differentiation by inhibiting proliferation of differentiating neurons through enhancement of
261:
160:
8126:
7761:
7277:
6850:
6689:
5624:
5619:
5604:
5079:
5054:
4936:
4887:
4680:
4071:
3537:
3383:
1212:
1141:
899:
79:
2600:
1341:-mediated pathways. This is either by direct interaction or through interaction with other molecules of the
8491:
6532:
5849:
4963:
4951:
2601:"Methylation of p16 and Ras Association Domain Family Protein 1a during Colorectal Malignant Transformation"
2498:"TGene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme"
2325:
Kobayashi A, Behringer RR (Dec 2003). "Developmental genetics of the female reproductive tract in mammals".
1408:. These pathways are still poorly understood. It is thought that ID4 plays a role in the transcription of
1169:
880:
8622:
6669:
6664:
5059:
4956:
4751:
4712:
3775:
3424:
1706:
of colorectal cancer. It is also frequently observed in liver metastases of colorectal cancer specimens.
1557:
1263:
1198:
8614:
8174:
4973:
4909:
4904:
4717:
3793:
1202:
1677:
and frequently expressed in gastric cancer cell lines. In contrast, ID4 is highly expressed in normal
8195:
8187:
6025:
5507:
5032:
5027:
5022:
4702:
4585:
3420:
2956:
2509:
1515:
1215:
1125:
143:
3389:
58:
8509:
8213:
7909:
6112:
5317:
4899:
4877:
4850:
4812:
4746:
1584:
1524:
1345:
machinery. ID4 also regulates the lateral expansion of the proliferative zone in the developing
1219:
2691:
Chan AS, Tsui WY, Chen X, Chu KM, Chan TL, Chan AS, Li R, So S, Yuen ST, Leung SY (October 2003).
2278:"Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4"
2227:
Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Zondervan KT, et al. (2011).
8047:
3192:
2896:
2555:
Umetani N, Giuliano AE, Hiramatsu SH, Amersi F, Nakagawa T, Martino S, Hoon DS (September 2006).
2437:
2350:
2075:
1468:
1323:
1300:
1274:
1239:
1231:
103:
3379:
1227:
1037:
1016:
990:
969:
1903:
7629:
7620:
7257:
6205:
4946:
4941:
3360:
3315:
3280:
3237:
3184:
3154:
3119:
3076:
3041:
3019:
2984:
2931:
2888:
2858:
2804:
2755:
2714:
2673:
2622:
2578:
2537:
2478:
2429:
2378:
2342:
2307:
2258:
2209:
2160:
2116:
2067:
2023:
1948:
1865:
1694:
1346:
1255:
51:
7440:
7435:
7430:
7425:
7420:
6512:
6156:
6138:
4707:
4654:
4428:
3350:
3340:
3305:
3270:
3262:
3227:
3217:
3176:
3144:
3109:
3101:
3066:
3009:
2974:
2964:
2921:
2880:
2848:
2840:
2794:
2786:
2745:
2704:
2663:
2653:
2612:
2568:
2527:
2517:
2468:
2419:
2409:
2334:
2297:
2289:
2248:
2240:
2199:
2191:
2150:
2106:
2057:
2013:
1938:
1930:
1857:
1723:
1567:
1536:
1429:
1327:
1278:
1181:
348:
279:
223:
178:
7600:
7595:
7545:
7535:
7515:
7500:
7480:
7405:
7385:
6527:
6522:
520:
8297:
7520:
7390:
6756:
6714:
6709:
6704:
6642:
6554:
6476:
6264:
6215:
6210:
4257:
3053:
Chan AS, Tsui WY, Chen X, Chu KM, Chan TL, Chan AS, Li R, So S, Yuen ST, Leung SY (2003).
2229:"Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis"
2046:"ID4 expression and its relationship to other ID genes during avian embryonic development"
1674:
1670:
1549:
1528:
1520:
1449:
1235:
323:
27:
3327:
Noetzel E, Veeck J, Niederacher D, Galm O, Horn F, Hartmann A, Knüchel R, Dahl E (2008).
2908:
Rigolet M, Rich T, Gross-Morand MS, Molina-Gomes D, Viegas-Pequignot E, Junien C (1999).
1887:"Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein"
1250:
The ID4 gene plays a pivotal role in development and is a key player in many pathways of
99:
2960:
2513:
1573:
The ID4 promoter region has been found to be hypermethylated and its mRNA suppressed in
513:
506:
8394:
6674:
6657:
4800:
4455:
3452:
3355:
3328:
3275:
3250:
3232:
3205:
3114:
3089:
2799:
2774:
2668:
2641:
2302:
2277:
2253:
2228:
2204:
2179:
1682:
1678:
1665:
1633:
1624:
1458:
3105:
2910:"cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene"
2853:
2828:
2557:"Prediction of breast tumor progression by integrity of free circulating DNA in serum"
2532:
2497:
2062:
2045:
1943:
1918:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
608:
603:
587:
582:
577:
572:
567:
562:
8850:
8840:
7252:
6592:
5017:
4805:
4133:
2979:
2944:
2732:
Umetani N, Mori T, Koyanagi K, Shinozaki M, Kim J, Giuliano AE, Hoon DS (July 2005).
1715:
1641:
1616:
1575:
1553:
1475:
1453:
1405:
1401:
1293:
1251:
1223:
1133:
1129:
549:
2900:
2079:
1209:. The heterodimer is what inhibits their DNA binding and transcriptional activity.
8802:
8114:
7997:
7989:
7360:
7316:
6319:
6167:
2441:
2354:
1645:
1498:
1206:
1153:
341:
120:
3196:
3149:
3132:
2617:
1979:
83:
3294:"Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma"
2414:
2293:
107:
8486:
8089:
6569:
6284:
6249:
4638:
4443:
4438:
3881:
3685:
3680:
3576:
3456:
2397:
1835:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1817:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1699:
1608:
1600:
1588:
1544:
1354:
1350:
1330:
1177:
2502:
Proceedings of the
National Academy of Sciences of the United States of America
2473:
2456:
424:
8798:
8749:
8221:
7825:
7734:
7714:
7687:
7034:
6783:
6632:
6620:
6615:
5614:
5609:
4373:
4368:
4346:
4212:
4030:
3734:
3675:
3670:
3650:
3206:"Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer"
3055:"Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma"
2693:"Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma"
2642:"Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer"
2599:
Umetani N, de Maat MG, Sunami E, Hiramatsu S, Martinez S, Hoon DB (May 2006).
1637:
1592:
1580:
1560:
1532:
1433:
1342:
1312:
1281:
1258:. ID4 expression is upregulated in embryogenesis during days 9.5 and 13.5 of
1137:
240:
137:
87:
2926:
2909:
2844:
2573:
2556:
1579:
cell lines including that of primary breast cancers. Patients with invasive
1506:(B-ALL), ID4 is overexpressed due to being located in close proximity to the
8672:
8662:
8645:
8119:
7138:
4843:
4272:
3930:
3345:
3131:
Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ, Hoon DS (2005).
2522:
2018:
2001:
1703:
1398:
1368:
a pathway which represses two inhibitors of cardiogenic mesoderm formation (
1334:
1259:
1145:
799:
484:
362:
307:
294:
206:
193:
95:
3364:
3319:
3284:
3241:
3222:
3188:
3158:
3123:
3080:
3071:
3054:
3045:
3023:
3014:
2997:
2988:
2808:
2759:
2750:
2733:
2718:
2709:
2692:
2677:
2658:
2626:
2582:
2541:
2482:
2433:
2382:
2346:
2311:
2262:
2213:
2195:
2164:
2139:"Id4 regulates neural progenitor proliferation and differentiation in vivo"
2071:
1934:
1861:
2969:
2935:
2892:
2885:
10.1002/(SICI)1097-4547(19971201)50:5<684::AID-JNR6>3.0.CO;2-D
2862:
2120:
2027:
1952:
1869:
1180:, is 16.6 KDa and contains a poly-Ala segment from amino acid 39 to 48, a
1101:
1096:
8139:
7917:
6279:
4838:
4795:
3847:
3266:
2790:
2112:
10.1002/(SICI)1097-0177(199611)207:3<235::AID-AJA1>3.0.CO;2-I
1720:
1629:
1612:
1564:
1364:
1304:
1289:
1285:
1149:
1085:
944:
925:
3310:
3293:
8539:
8519:
8514:
8226:
6200:
5984:
3896:
3891:
3886:
3874:
3869:
1689:
1657:
1653:
1649:
1604:
1596:
1361:
1308:
1234:. Consequently, ID proteins inhibit binding to DNA and transcriptional
1117:
911:
866:
2155:
2138:
8720:
8715:
8710:
8700:
8695:
8414:
7969:
7964:
7959:
7954:
7220:
7215:
7092:
7087:
7082:
7067:
7058:
7053:
7048:
7027:
6941:
6936:
6724:
6719:
6699:
6694:
6684:
6679:
6517:
6469:
6464:
6459:
6454:
6424:
6419:
6414:
6409:
6379:
6329:
6324:
6087:
6007:
5979:
5974:
5969:
5964:
5959:
5954:
5949:
5944:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5904:
5899:
5894:
5884:
5879:
5874:
5869:
5864:
5859:
5854:
5844:
5839:
5834:
5794:
5747:
5742:
5737:
5732:
5727:
5722:
5712:
5700:
5695:
5461:
5456:
5451:
5333:
5328:
5300:
5295:
5280:
5275:
5270:
5260:
5255:
5243:
5238:
4610:
4605:
4600:
4595:
4590:
4565:
4492:
4460:
4403:
4398:
4185:
4180:
4175:
4059:
3864:
3754:
3749:
3722:
3717:
3712:
3638:
2424:
1489:
1485:
1481:
1413:
1222:
of the bHLH proteins is dependent on formation of homo- and/or hetero
1069:
821:
578:
DNA-binding transcription factor activity, RNA polymerase II-specific
2338:
2137:
Yun K, Mantani A, Garel S, Rubenstein J, Israel MA (November 2004).
3180:
2244:
1318:
ID4 is expressed in the central nervous system and is required for
8764:
8742:
8737:
8705:
8594:
8589:
8534:
8529:
8524:
8468:
8377:
8372:
8367:
8362:
8357:
8352:
8347:
8342:
8290:
8285:
8273:
8268:
8263:
8258:
8246:
8241:
8236:
8231:
8200:
8167:
8162:
8157:
8104:
8099:
8094:
8069:
8027:
8022:
8017:
8012:
8007:
8002:
7974:
7927:
7922:
7868:
7863:
7858:
7853:
7830:
7605:
7590:
7585:
7580:
7575:
7570:
7565:
7560:
7555:
7550:
7540:
7530:
7525:
7510:
7505:
7495:
7490:
7485:
7475:
7470:
7465:
7460:
7455:
7450:
7445:
7415:
7410:
7400:
7395:
7380:
7375:
7370:
7365:
7299:
7294:
7289:
7262:
7237:
7205:
7198:
7193:
7099:
7077:
7072:
7044:
7022:
7017:
7012:
7007:
6902:
6897:
6842:
6835:
6830:
6815:
6788:
6449:
6444:
6439:
6434:
6429:
6404:
6399:
6394:
6389:
6384:
6374:
6369:
6364:
6359:
6354:
6349:
6344:
6339:
6334:
6314:
6309:
6304:
6299:
6294:
6289:
6274:
6269:
6094:
6082:
6077:
6072:
6067:
6035:
6030:
5829:
5819:
5814:
5809:
5804:
5799:
5789:
5784:
5779:
5774:
5690:
5680:
5673:
5668:
5663:
5658:
5648:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5483:
5478:
5473:
5417:
5412:
5311:
5290:
5285:
5159:
5154:
5149:
5144:
5139:
5134:
4341:
4106:
4101:
4096:
4086:
4081:
4076:
4066:
4054:
4004:
3984:
3925:
3913:
3908:
3832:
3825:
3820:
3810:
3803:
3798:
3729:
3660:
3633:
3628:
3611:
3606:
3601:
3596:
3591:
3581:
3569:
3564:
3542:
3532:
3527:
3517:
1741:
Protein, Class B Basic Helix-Loop-Helix
Protein 27, and BHLHb272.
1445:
1409:
1381:
1373:
1165:
784:
780:
8791:
8786:
8781:
8771:
8759:
8754:
8601:
8584:
8448:
8443:
8438:
8409:
8404:
8337:
8332:
8327:
8322:
8317:
8312:
8307:
8302:
8253:
8147:
8109:
8084:
8079:
8074:
8057:
7949:
7942:
7937:
7818:
7813:
7808:
7803:
7798:
7793:
7788:
7783:
7773:
7766:
7756:
7751:
7739:
7729:
7724:
7707:
7702:
7697:
7680:
7675:
7670:
7645:
7640:
7635:
7353:
7348:
7343:
7338:
7333:
7272:
7247:
7242:
7183:
7178:
7173:
7168:
7163:
7158:
7153:
7148:
7143:
7114:
7109:
7002:
6997:
6992:
6987:
6973:
6968:
6963:
6958:
6953:
6924:
6919:
6914:
6880:
6875:
6870:
6865:
6860:
6855:
6820:
6808:
6803:
6798:
6751:
6746:
6741:
6736:
6731:
6652:
6637:
6627:
6603:
6598:
6584:
6579:
6574:
6564:
6559:
6547:
6542:
6486:
6481:
6259:
6244:
6239:
6227:
6222:
6055:
6050:
6045:
5889:
5824:
5769:
5764:
5759:
5643:
5638:
5633:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5500:
5495:
5439:
5434:
5402:
5397:
5392:
5382:
5377:
5370:
5365:
5360:
5355:
5345:
5340:
5323:
5181:
5176:
5171:
5099:
4560:
4555:
4550:
4545:
4540:
4535:
4448:
4433:
4410:
4383:
4356:
4351:
4316:
4294:
4289:
4284:
4267:
4262:
4252:
4242:
4192:
4150:
4145:
4128:
4123:
4118:
4016:
4011:
3999:
3957:
3952:
3942:
3857:
3852:
3842:
3761:
3744:
3707:
3695:
3690:
3665:
3623:
3552:
3547:
3522:
3505:
3500:
3495:
3490:
3485:
3475:
1904:"Atlas of Genetics and Cytogenetics in Oncology and Haematology"
1377:
1369:
1319:
1173:
1121:
75:
8562:
7891:
6133:
4633:
3435:
3393:
529:
8433:
8062:
8052:
7932:
7328:
6885:
6234:
5685:
5422:
4916:
4388:
4207:
4202:
3994:
3989:
3292:
Hagiwara K, Nagai H, Li Y, Ohashi H, Hotta T, Saito H (2007).
1338:
1164:
The gene spans 3.3kb on the plus strand. It is composed of 3
2276:
Ren Y, Cheung HW, von
Maltzhan G, et al. (August 2012).
19:
For the film which uses "ID4" as a marketing initialism, see
2996:
Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002).
1673:
is hypermethylated and infrequently expressed in gastric
1463:. The ID4 gene is also seen to be overexpressed in most
745:
positive regulation of transcription by RNA polymerase II
660:
negative regulation of transcription by RNA polymerase II
2178:
Cunningham TJ, Yu MS, McKeithan WL, et al. (2017).
331:
62:, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
1615:
is responsible for regulation of ID4 expression in the
1360:
ID4 was also shown to be involved in the regulation of
695:
negative regulation of oligodendrocyte differentiation
2000:
Pagliuca A, Cannada-Bartoli P, Lania L (March 1998).
1556:, the ID4 gene has been shown to be expressed in the
1416:
which are known to be associated with endometriosis.
496:
3298:
Journal of
Clinical and Experimental Hematopathology
2132:
2130:
705:
positive regulation of cell population proliferation
8681:
8641:
8610:
8575:
8500:
8477:
8459:
8209:
8183:
8135:
8038:
7985:
7905:
7839:
7656:
7616:
7312:
7129:
6769:
6495:
6183:
6164:
6152:
6103:
6016:
5995:
5197:
5117:
5088:
5068:
5043:
5006:
4925:
4821:
4669:
4650:
4576:
4521:
4419:
4329:
4305:
4228:
4161:
4025:
3975:
3784:
3770:
3448:
1622:It is unclear whether the ID4 gene plays a role in
1030:
1009:
983:
962:
730:
negative regulation of transcription, DNA-templated
3204:Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA (2006).
2640:Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA (2005).
2180:"Id genes are essential for early heart formation"
1791:
1789:
1787:
1770:
1768:
1766:
1595:. ID4 is constitutively expressed in normal human
1917:Riechmann V, van Crüchten I, Sablitzky F (1994).
1583:have shown ID4 expression in their breast cancer
1452:. It has been shown to be overexpressed in most
1333:. It is complexly involved in regulating neural
1176:is 2343 bp. The encoded protein consists of 161
685:positive regulation of osteoblast differentiation
278:
177:
1315:in the developing stomach during embryogenesis.
655:regulation of transcription by RNA polymerase II
635:negative regulation of astrocyte differentiation
630:negative regulation of fat cell differentiation
1796:GRCm38: Ensembl release 89: ENSMUSG00000021379
8824:transcription factor/coregulator deficiencies
7895:β-Scaffold factors with minor groove contacts
3405:
2773:Peddada S, Yasui DH, LaSalle JM (June 2006).
1587:. This has been identified as a significant
645:negative regulation of neuron differentiation
8:
2093:Jen Y, Manova K, Benezra R (November 1996).
3088:Shan L, Yu M, Qiu C, Snyderwine EG (2004).
1775:GRCh38: Ensembl release 89: ENSG00000172201
1688:ID4 is not found in normal epitheliums nor
8837:United States National Library of Medicine
8572:
8559:
7902:
7888:
6180:
6161:
6149:
6130:
4666:
4647:
4630:
3781:
3445:
3432:
3412:
3398:
3390:
2594:
2592:
2039:
2037:
1292:. Later stages show ID4 expression in the
795:
640:regulation of transcription, DNA-templated
545:
319:
218:
115:
3382:at the U.S. National Library of Medicine
3354:
3344:
3309:
3274:
3231:
3221:
3148:
3113:
3070:
3013:
2978:
2968:
2925:
2852:
2798:
2749:
2708:
2667:
2657:
2616:
2572:
2531:
2521:
2472:
2423:
2413:
2301:
2252:
2203:
2154:
2110:
2061:
2044:Kee Y, Bronner-Fraser M (December 2001).
2017:
1942:
1660:, but also seen in fresh cancer tissues.
1599:epithelium but found to be suppressed in
1197:that work by negatively regulating their
583:DNA-binding transcription factor activity
8835:This article incorporates text from the
3249:Peddada S, Yasui DH, LaSalle JM (2006).
1898:
1896:
1881:
1879:
1262:and restricted to specific cells of the
2827:Loveys DA, Streiff MB, Kato GJ (1996).
1762:
690:prostate gland epithelium morphogenesis
1966:Riechmann V, Sablitzky F (July 1995).
1303:. ID4 expression is only detected in
720:cerebral cortex neuron differentiation
680:positive regulation of gene expression
32:
750:G1/S transition of mitotic cell cycle
283:
244:
239:
182:
141:
136:
7:
1632:which is frequently associated with
1603:breast carcinomas and preneoplastic
625:prostate gland stromal morphogenesis
26:. For the battery electric car, see
4578:(1.6) Basic helix-span-helix (bHSH)
1027:
1006:
980:
959:
935:
916:
890:
871:
845:
826:
760:negative regulation of DNA binding
650:central nervous system myelination
568:transcription corepressor activity
501:
419:
357:
336:
14:
1972:Cell Growth & Differentiation
1751:Inhibitor of DNA-binding protein
1357:much later than other ID genes.
519:
512:
505:
267:
260:
254:
231:
166:
159:
153:
128:
8565:(0) Other transcription factors
7849:transcriptional enhancer factor
3466:Activating transcription factor
2006:Journal of Biological Chemistry
1663:ID4 is closely associated with
1444:ID4 is not expressed in normal
1246:Regulation during embryogenesis
2282:Science Translational Medicine
1628:. ID4 is found on the 6p22.3
1426:single nucleotide polymorphism
1376:) whilst activating inducers (
530:More reference expression data
485:More reference expression data
1:
7779:Interferon regulatory factors
6018:(2.5) Alternating composition
5214:General transcription factors
3150:10.1158/1078-0432.CCR-04-0689
3106:10.1016/S0002-9440(10)63604-8
2618:10.1158/1541-7786.MCR-05-0199
2063:10.1016/S0925-4773(01)00576-7
1503:acute lymphoblastic leukaemia
1421:genome wide association study
725:cell population proliferation
670:seminal vesicle morphogenesis
563:protein dimerization activity
252:
151:
16:Protein-coding gene in humans
7064:Octamer transcription factor
3772:(1.2) Basic helix-loop-helix
2949:Proc. Natl. Acad. Sci. U.S.A
2561:Journal of Clinical Oncology
2415:10.1182/blood-2007-07-092015
2294:10.1126/scitranslmed.3003778
710:prostate gland morphogenesis
665:transcription, DNA-templated
588:transcription factor binding
8857:Genes on human chromosome 6
3838:Myogenic regulatory factors
1397:ID4 has been linked to the
8878:
2474:10.1016/j.stem.2007.10.020
1322:transition and to enhance
1195:transcriptional regulators
770:osteoblast differentiation
409:left lobe of thyroid gland
18:
8819:
8571:
8558:
7901:
7887:
7658:(3.5) Tryptophan clusters
6148:
6129:
4646:
4629:
3444:
3431:
2605:Molecular Cancer Research
2050:Mechanisms of Development
1978:: 837–843. Archived from
1831:"Mouse PubMed Reference:"
1813:"Human PubMed Reference:"
1563:but not expressed in the
1440:Tumorigenesis association
1268:peripheral nervous system
1134:embryonic cellular growth
1100:
1095:
1091:
1084:
1068:
1049:
1034:
1013:
1002:
987:
966:
955:
942:
938:
923:
919:
910:
897:
893:
878:
874:
865:
852:
848:
833:
829:
820:
805:
798:
794:
778:
548:
544:
527:
504:
495:
482:
431:
422:
369:
360:
330:
322:
318:
301:
288:
251:
230:
221:
217:
200:
187:
150:
127:
118:
114:
69:
66:
56:
49:
44:
40:
35:
8479:(4.10) Cold-shock domain
3384:Medical Subject Headings
2779:Human Molecular Genetics
2574:10.1200/JCO.2006.05.9493
2327:Nature Reviews. Genetics
1232:DNA-binding basic domain
1142:cellular differentiation
1132:. This is inclusive of
1062:Chr 13: 48.41 – 48.42 Mb
765:regulation of cell cycle
740:fat cell differentiation
715:neuroblast proliferation
439:Rostral migratory stream
3425:intracellular receptors
3346:10.1186/1471-2407-8-154
2523:10.1073/pnas.0402870102
2184:Genes & Development
2019:10.1074/jbc.273.13.7668
1710:Developmental disorders
1055:Chr 6: 19.84 – 19.84 Mb
735:hippocampus development
3223:10.1186/1476-4598-4-16
3072:10.1038/sj.onc.1206799
3015:10.1074/jbc.M107713200
2927:10.1093/dnares/5.5.309
2845:10.1093/nar/24.14.2813
2751:10.1038/sj.onc.1208538
2710:10.1038/sj.onc.1206799
2659:10.1186/1476-4598-4-16
2196:10.1101/gad.300400.117
2099:Developmental Dynamics
1923:Nucleic Acids Research
1862:10.1006/geno.1995.1026
1432:rs7739264 near ID4 on
1284:, the segmental plate
1199:basic helix-loop-helix
755:neuron differentiation
451:lateral septal nucleus
285:13 A5|13 24.71 cM
8862:Transcription factors
8188:TATA-binding proteins
3421:Transcription factors
2970:10.1073/pnas.98.1.130
1393:Role in endometriosis
1388:Clinical significance
1203:transcription factors
447:medial dorsal nucleus
246:Chromosome 13 (mouse)
1935:10.1093/nar/22.5.749
1548:, more specifically
1525:follicular lymphomas
1516:Non Hodgkin lymphoma
1242:with bHLH proteins.
1220:DNA-binding activity
1126:prenatal development
144:Chromosome 6 (human)
8683:(0.6) Miscellaneous
8214:High-mobility group
7910:Rel homology region
4900:Testicular receptor
4641:DNA-binding domains
3311:10.3960/jslrt.47.15
2961:2001PNAS...98..130B
2514:2005PNAS..102.5814L
1736:Commonly used names
1731:Society and culture
385:germinal epithelium
8839:, which is in the
8048:p53 p63 p73 family
7621:Heat shock factors
3380:ID4+protein,+human
3267:10.1093/hmg/ddl124
2791:10.1093/hmg/ddl124
1535:cell lines due to
1301:corneal epithelium
1275:neural crest cells
1256:foetal development
1240:heterodimerization
900:ENSMUSG00000021379
618:Biological process
597:Cellular component
556:Molecular function
455:supraoptic nucleus
435:olfactory tubercle
8831:
8830:
8815:
8814:
8811:
8810:
8554:
8553:
8550:
8549:
7883:
7882:
7879:
7878:
7125:
7124:
6765:
6764:
6125:
6124:
6121:
6120:
5113:
5112:
4969:Mineralocorticoid
4625:
4624:
4621:
4620:
4325:
4324:
3438:(1) Basic domains
2833:Nucleic Acids Res
2785:(12): 2003–2014.
2744:(29): 4721–4727.
2703:(44): 6946–6953.
2567:(26): 4270–4276.
2508:(16): 5814–5819.
2288:(147): 147ra112.
2190:(13): 1325–1338.
2156:10.1242/dev.01430
2149:(21): 5441–5448.
2012:(13): 7668–7674.
1695:colorectal cancer
1656:and parts of the
1644:inclusive of the
1523:is implicated in
1510:enhancer region.
1228:Dominant-negative
1111:
1110:
1107:
1106:
1080:
1079:
1045:
1044:
1024:
1023:
998:
997:
977:
976:
951:
950:
932:
931:
906:
905:
887:
886:
861:
860:
842:
841:
790:
789:
675:brain development
540:
539:
536:
535:
491:
490:
478:
477:
459:nucleus accumbens
416:
415:
314:
313:
213:
212:
8869:
8655:-related factors
8573:
8560:
8461:(4.9) Grainyhead
7903:
7889:
7841:(3.6) TEA domain
7131:(3.2) Paired box
6772:
6506:
6500:
6194:
6188:
6181:
6177:
6171:
6162:
6150:
6139:Helix-turn-helix
6131:
5093:
5073:
5048:
5011:
4981:Estrogen related
4930:
4826:
4674:
4667:
4655:Nuclear receptor
4648:
4631:
4310:
4231:
4164:
4033:
3978:
3787:
3782:
3446:
3433:
3414:
3407:
3400:
3391:
3368:
3358:
3348:
3323:
3313:
3288:
3278:
3245:
3235:
3225:
3200:
3162:
3152:
3137:Clin. Cancer Res
3127:
3117:
3084:
3074:
3049:
3027:
3017:
2992:
2982:
2972:
2939:
2929:
2904:
2873:J. Neurosci. Res
2866:
2856:
2813:
2812:
2802:
2770:
2764:
2763:
2753:
2729:
2723:
2722:
2712:
2688:
2682:
2681:
2671:
2661:
2646:Molecular Cancer
2637:
2631:
2630:
2620:
2596:
2587:
2586:
2576:
2552:
2546:
2545:
2535:
2525:
2493:
2487:
2486:
2476:
2452:
2446:
2445:
2427:
2417:
2393:
2387:
2386:
2365:
2359:
2358:
2322:
2316:
2315:
2305:
2273:
2267:
2266:
2256:
2224:
2218:
2217:
2207:
2175:
2169:
2168:
2158:
2134:
2125:
2124:
2114:
2090:
2084:
2083:
2065:
2041:
2032:
2031:
2021:
1997:
1991:
1990:
1988:
1987:
1963:
1957:
1956:
1946:
1914:
1908:
1907:
1900:
1891:
1890:
1883:
1874:
1873:
1845:
1839:
1838:
1827:
1821:
1820:
1809:
1803:
1793:
1782:
1772:
1724:neurodevelopment
1640:which lines the
1568:oligodendrocytes
1550:oligodendroglial
1537:hypermethylation
1529:B Cell lymphomas
1307:tissues and the
1182:helix-loop-helix
1093:
1092:
1064:
1057:
1040:
1028:
1019:
1007:
1003:RefSeq (protein)
993:
981:
972:
960:
936:
917:
891:
872:
846:
827:
796:
700:circadian rhythm
546:
532:
523:
516:
509:
502:
487:
427:
425:Top expressed in
420:
405:seminal vesicula
381:ventricular zone
365:
363:Top expressed in
358:
337:
320:
310:
297:
286:
271:
264:
258:
247:
235:
219:
209:
196:
185:
170:
163:
157:
146:
132:
116:
110:
61:
54:
33:
22:Independence Day
8877:
8876:
8872:
8871:
8870:
8868:
8867:
8866:
8847:
8846:
8832:
8827:
8807:
8677:
8637:
8606:
8567:
8546:
8496:
8473:
8455:
8205:
8179:
8131:
8034:
7981:
7897:
7875:
7835:
7652:
7612:
7308:
7121:
6770:
6761:
6502:
6501:
6496:
6491:
6190:
6189:
6184:
6173:
6172:
6165:
6144:
6117:
6099:
6012:
6000:
5991:
5206:
5202:
5193:
5122:
5119:(2.2) Other Cys
5109:
5089:
5084:
5069:
5064:
5044:
5039:
5007:
5002:
4937:Steroid hormone
4926:
4921:
4822:
4817:
4681:Thyroid hormone
4670:
4661:
4642:
4617:
4572:
4517:
4415:
4321:
4308:
4306:
4301:
4229:
4224:
4162:
4157:
4028:
4026:
4021:
3976:
3971:
3785:
3766:
3440:
3427:
3418:
3376:
3371:
3326:
3291:
3261:(12): 2003–14.
3255:Hum. Mol. Genet
3248:
3203:
3165:
3143:(22): 7475–83.
3130:
3100:(6): 2495–502.
3087:
3065:(44): 6946–53.
3052:
3040:(9): 994–1001.
3030:
3008:(11): 9118–26.
2995:
2942:
2907:
2869:
2839:(14): 2813–20.
2826:
2822:
2820:Further reading
2817:
2816:
2772:
2771:
2767:
2731:
2730:
2726:
2690:
2689:
2685:
2639:
2638:
2634:
2598:
2597:
2590:
2554:
2553:
2549:
2495:
2494:
2490:
2454:
2453:
2449:
2395:
2394:
2390:
2377:(9): 994–1001.
2367:
2366:
2362:
2339:10.1038/nrg1225
2333:(12): 969–980.
2324:
2323:
2319:
2275:
2274:
2270:
2233:Nature Genetics
2226:
2225:
2221:
2177:
2176:
2172:
2136:
2135:
2128:
2092:
2091:
2087:
2043:
2042:
2035:
1999:
1998:
1994:
1985:
1983:
1965:
1964:
1960:
1916:
1915:
1911:
1902:
1901:
1894:
1885:
1884:
1877:
1847:
1846:
1842:
1829:
1828:
1824:
1811:
1810:
1806:
1794:
1785:
1773:
1764:
1759:
1747:
1738:
1733:
1712:
1675:adenocarcinomas
1671:promoter region
1521:promoter region
1460:ovarian cancers
1450:fallopian tubes
1442:
1395:
1390:
1311:portion of the
1248:
1236:transactivation
1190:
1162:
1102:View/Edit Mouse
1097:View/Edit Human
1060:
1053:
1050:Location (UCSC)
1036:
1015:
989:
968:
881:ENSG00000172201
774:
613:
592:
573:protein binding
528:
518:
517:
511:
510:
483:
474:
469:
467:globus pallidus
465:
461:
457:
453:
449:
445:
441:
437:
423:
412:
407:
403:
399:
395:
391:
387:
383:
379:
375:
361:
305:
292:
284:
274:
273:
272:
265:
245:
222:Gene location (
204:
191:
183:
173:
172:
171:
164:
142:
119:Gene location (
108:ID4 - orthologs
70:
57:
50:
31:
28:Volkswagen ID.4
17:
12:
11:
5:
8875:
8873:
8865:
8864:
8859:
8849:
8848:
8829:
8828:
8820:
8817:
8816:
8813:
8812:
8809:
8808:
8806:
8805:
8796:
8795:
8794:
8789:
8784:
8774:
8769:
8768:
8767:
8762:
8757:
8747:
8746:
8745:
8740:
8730:
8725:
8724:
8723:
8718:
8713:
8708:
8703:
8698:
8687:
8685:
8679:
8678:
8676:
8675:
8670:
8665:
8659:
8657:
8639:
8638:
8636:
8635:
8630:
8625:
8619:
8617:
8608:
8607:
8605:
8604:
8599:
8598:
8597:
8592:
8581:
8579:
8569:
8568:
8563:
8556:
8555:
8552:
8551:
8548:
8547:
8545:
8544:
8543:
8542:
8537:
8532:
8527:
8522:
8517:
8506:
8504:
8498:
8497:
8495:
8494:
8489:
8483:
8481:
8475:
8474:
8472:
8471:
8465:
8463:
8457:
8456:
8454:
8453:
8452:
8451:
8446:
8441:
8436:
8426:
8425:
8424:
8419:
8418:
8417:
8412:
8407:
8392:
8387:
8382:
8381:
8380:
8375:
8370:
8365:
8360:
8355:
8350:
8345:
8340:
8335:
8330:
8325:
8320:
8315:
8310:
8305:
8295:
8294:
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8288:
8278:
8277:
8276:
8271:
8266:
8261:
8251:
8250:
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8234:
8224:
8218:
8216:
8207:
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8203:
8198:
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8165:
8160:
8155:
8144:
8142:
8133:
8132:
8130:
8129:
8124:
8123:
8122:
8117:
8112:
8107:
8102:
8097:
8092:
8087:
8082:
8077:
8067:
8066:
8065:
8060:
8055:
8044:
8042:
8040:(4.3) p53-like
8036:
8035:
8033:
8032:
8031:
8030:
8025:
8020:
8015:
8010:
8005:
7994:
7992:
7983:
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7972:
7967:
7962:
7957:
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7912:
7899:
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7877:
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7866:
7861:
7856:
7845:
7843:
7837:
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7828:
7823:
7822:
7821:
7816:
7811:
7806:
7801:
7796:
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7776:
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7769:
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7759:
7754:
7744:
7743:
7742:
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7727:
7717:
7712:
7711:
7710:
7705:
7700:
7690:
7685:
7684:
7683:
7678:
7673:
7662:
7660:
7654:
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7651:
7650:
7649:
7648:
7643:
7638:
7625:
7623:
7614:
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7611:
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7609:
7608:
7603:
7598:
7593:
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7568:
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7538:
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7528:
7523:
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7513:
7508:
7503:
7498:
7493:
7488:
7483:
7478:
7473:
7468:
7463:
7458:
7453:
7448:
7443:
7438:
7433:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7388:
7383:
7378:
7373:
7368:
7358:
7357:
7356:
7351:
7346:
7341:
7336:
7325:
7323:
7310:
7309:
7307:
7306:
7305:
7304:
7303:
7302:
7297:
7292:
7282:
7281:
7280:
7275:
7265:
7260:
7250:
7245:
7240:
7235:
7230:
7225:
7224:
7223:
7218:
7208:
7203:
7202:
7201:
7196:
7188:
7187:
7186:
7181:
7176:
7171:
7166:
7161:
7156:
7151:
7146:
7135:
7133:
7127:
7126:
7123:
7122:
7120:
7119:
7118:
7117:
7112:
7102:
7097:
7096:
7095:
7090:
7085:
7080:
7075:
7070:
7061:
7056:
7051:
7042:
7032:
7031:
7030:
7025:
7020:
7015:
7010:
7005:
7000:
6995:
6990:
6980:
6979:
6978:
6977:
6976:
6971:
6966:
6961:
6956:
6946:
6945:
6944:
6939:
6929:
6928:
6927:
6922:
6917:
6907:
6906:
6905:
6900:
6890:
6889:
6888:
6883:
6878:
6873:
6868:
6863:
6858:
6845:
6840:
6839:
6838:
6833:
6823:
6818:
6813:
6812:
6811:
6806:
6801:
6791:
6786:
6781:
6775:
6773:
6767:
6766:
6763:
6762:
6760:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6728:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6677:
6667:
6662:
6661:
6660:
6655:
6645:
6640:
6635:
6630:
6625:
6624:
6623:
6618:
6608:
6607:
6606:
6601:
6589:
6588:
6587:
6582:
6577:
6572:
6567:
6562:
6552:
6551:
6550:
6545:
6535:
6530:
6525:
6520:
6515:
6509:
6507:
6493:
6492:
6490:
6489:
6484:
6479:
6474:
6473:
6472:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6367:
6362:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6322:
6317:
6312:
6307:
6302:
6297:
6292:
6287:
6277:
6272:
6267:
6262:
6258:extended Hox:
6256:
6255:
6254:
6253:
6252:
6247:
6242:
6232:
6231:
6230:
6220:
6219:
6218:
6213:
6197:
6195:
6178:
6159:
6146:
6145:
6134:
6127:
6126:
6123:
6122:
6119:
6118:
6116:
6115:
6109:
6107:
6101:
6100:
6098:
6097:
6092:
6091:
6090:
6085:
6080:
6075:
6070:
6060:
6059:
6058:
6053:
6048:
6038:
6033:
6028:
6022:
6020:
6014:
6013:
6011:
6010:
6004:
6002:
5998:
5993:
5992:
5990:
5989:
5988:
5987:
5982:
5977:
5972:
5967:
5962:
5957:
5952:
5947:
5942:
5937:
5932:
5927:
5922:
5917:
5912:
5907:
5902:
5897:
5892:
5887:
5882:
5877:
5872:
5867:
5862:
5857:
5852:
5847:
5842:
5837:
5832:
5827:
5822:
5817:
5812:
5807:
5802:
5797:
5792:
5787:
5782:
5777:
5772:
5767:
5762:
5752:
5751:
5750:
5745:
5740:
5735:
5730:
5725:
5720:
5715:
5705:
5704:
5703:
5698:
5688:
5683:
5678:
5677:
5676:
5671:
5666:
5661:
5651:
5646:
5641:
5636:
5631:
5630:
5629:
5628:
5627:
5622:
5617:
5612:
5607:
5597:
5596:
5595:
5590:
5585:
5580:
5575:
5570:
5565:
5560:
5555:
5550:
5545:
5540:
5535:
5530:
5525:
5520:
5505:
5504:
5503:
5498:
5488:
5487:
5486:
5481:
5476:
5466:
5465:
5464:
5459:
5454:
5444:
5443:
5442:
5437:
5427:
5426:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5385:
5380:
5375:
5374:
5373:
5368:
5363:
5358:
5348:
5343:
5338:
5337:
5336:
5331:
5326:
5314:
5308:
5307:
5306:
5305:
5304:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5258:
5253:
5248:
5247:
5246:
5241:
5231:
5226:
5221:
5210:
5208:
5204:
5200:
5195:
5194:
5192:
5191:
5186:
5185:
5184:
5179:
5174:
5164:
5163:
5162:
5157:
5152:
5147:
5142:
5137:
5126:
5124:
5120:
5115:
5114:
5111:
5110:
5108:
5107:
5102:
5096:
5094:
5086:
5085:
5083:
5082:
5076:
5074:
5066:
5065:
5063:
5062:
5057:
5051:
5049:
5041:
5040:
5038:
5037:
5036:
5035:
5030:
5025:
5014:
5012:
5004:
5003:
5001:
5000:
4999:
4998:
4993:
4988:
4978:
4977:
4976:
4971:
4966:
4964:Glucocorticoid
4961:
4960:
4959:
4954:
4944:
4933:
4931:
4923:
4922:
4920:
4919:
4914:
4913:
4912:
4907:
4897:
4896:
4895:
4890:
4885:
4875:
4870:
4869:
4868:
4863:
4853:
4848:
4847:
4846:
4841:
4829:
4827:
4819:
4818:
4816:
4815:
4810:
4809:
4808:
4803:
4793:
4792:
4791:
4786:
4781:
4771:
4770:
4769:
4764:
4759:
4749:
4744:
4743:
4742:
4737:
4732:
4722:
4721:
4720:
4715:
4705:
4700:
4695:
4694:
4693:
4688:
4677:
4675:
4664:
4659:
4644:
4643:
4634:
4627:
4626:
4623:
4622:
4619:
4618:
4616:
4615:
4614:
4613:
4608:
4603:
4598:
4593:
4582:
4580:
4574:
4573:
4571:
4570:
4569:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4527:
4525:
4519:
4518:
4516:
4515:
4514:
4513:
4507:
4506:
4505:
4500:
4490:
4489:
4488:
4483:
4478:
4473:
4468:
4453:
4452:
4451:
4446:
4441:
4436:
4425:
4423:
4417:
4416:
4414:
4413:
4408:
4407:
4406:
4401:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4360:
4359:
4354:
4344:
4338:
4336:
4327:
4326:
4323:
4322:
4320:
4319:
4313:
4311:
4303:
4302:
4300:
4299:
4298:
4297:
4292:
4287:
4277:
4276:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4234:
4232:
4226:
4225:
4223:
4222:
4221:
4220:
4215:
4210:
4205:
4195:
4190:
4189:
4188:
4183:
4178:
4167:
4165:
4159:
4158:
4156:
4155:
4154:
4153:
4148:
4138:
4137:
4136:
4131:
4126:
4121:
4111:
4110:
4109:
4104:
4099:
4091:
4090:
4089:
4084:
4079:
4069:
4064:
4063:
4062:
4057:
4047:
4042:
4036:
4034:
4023:
4022:
4020:
4019:
4014:
4009:
4008:
4007:
4002:
3997:
3987:
3981:
3979:
3973:
3972:
3970:
3969:
3964:
3963:
3962:
3961:
3960:
3955:
3945:
3935:
3934:
3933:
3928:
3918:
3917:
3916:
3911:
3901:
3900:
3899:
3894:
3889:
3879:
3878:
3877:
3872:
3862:
3861:
3860:
3855:
3850:
3845:
3835:
3830:
3829:
3828:
3823:
3813:
3808:
3807:
3806:
3801:
3790:
3788:
3779:
3768:
3767:
3765:
3764:
3759:
3758:
3757:
3752:
3747:
3737:
3732:
3727:
3726:
3725:
3720:
3715:
3710:
3700:
3699:
3698:
3693:
3688:
3683:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3642:
3641:
3636:
3631:
3621:
3620:
3619:
3614:
3609:
3604:
3599:
3594:
3584:
3579:
3574:
3573:
3572:
3567:
3557:
3556:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3510:
3509:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3473:
3462:
3460:
3453:leucine zipper
3442:
3441:
3436:
3429:
3428:
3419:
3417:
3416:
3409:
3402:
3394:
3388:
3387:
3375:
3374:External links
3372:
3370:
3369:
3324:
3289:
3246:
3201:
3181:10.1038/ng1521
3163:
3128:
3085:
3050:
3028:
2993:
2940:
2905:
2879:(5): 684–701.
2867:
2823:
2821:
2818:
2815:
2814:
2765:
2724:
2683:
2632:
2611:(5): 303–309.
2588:
2547:
2488:
2467:(6): 685–697.
2461:Cell Stem Cell
2447:
2408:(1): 387–391.
2388:
2360:
2317:
2268:
2245:10.1038/ng.731
2219:
2170:
2126:
2105:(3): 235–252.
2085:
2056:(2): 341–345.
2033:
1992:
1958:
1929:(5): 749–755.
1909:
1892:
1875:
1840:
1822:
1804:
1783:
1761:
1760:
1758:
1755:
1754:
1753:
1746:
1743:
1737:
1734:
1732:
1729:
1711:
1708:
1683:microsatellite
1679:gastric mucosa
1666:gastric cancer
1625:bladder cancer
1617:mammary ductal
1441:
1438:
1394:
1391:
1389:
1386:
1247:
1244:
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1021:
1011:
1010:
1004:
1000:
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995:
985:
984:
978:
975:
974:
964:
963:
957:
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952:
949:
948:
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939:
933:
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929:
921:
920:
914:
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907:
904:
903:
895:
894:
888:
885:
884:
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875:
869:
863:
862:
859:
858:
850:
849:
843:
840:
839:
831:
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824:
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812:
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802:
792:
791:
788:
787:
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702:
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682:
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611:
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533:
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489:
488:
480:
479:
476:
475:
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324:RNA expression
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2:
8874:
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8841:public domain
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8615:Pocket domain
8613:
8609:
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8600:
8596:
8593:
8591:
8588:
8587:
8586:
8583:
8582:
8580:
8578:
8577:(0.2) HMGI(Y)
8574:
8570:
8566:
8561:
8557:
8541:
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5510:
5509:
5508:Sp/KLF family
5506:
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4799:
4798:
4797:
4794:
4790:
4787:
4785:
4782:
4780:
4777:
4776:
4775:
4772:
4768:
4765:
4763:
4760:
4758:
4755:
4754:
4753:
4750:
4748:
4745:
4741:
4738:
4736:
4733:
4731:
4728:
4727:
4726:
4723:
4719:
4716:
4714:
4711:
4710:
4709:
4706:
4704:
4701:
4699:
4696:
4692:
4689:
4687:
4684:
4683:
4682:
4679:
4678:
4676:
4673:
4668:
4665:
4663:
4656:
4653:
4649:
4645:
4640:
4637:
4632:
4628:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4588:
4587:
4584:
4583:
4581:
4579:
4575:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4533:
4532:
4529:
4528:
4526:
4524:
4520:
4511:
4508:
4504:
4501:
4499:
4496:
4495:
4494:
4491:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4463:
4462:
4459:
4458:
4457:
4454:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4431:
4430:
4427:
4426:
4424:
4422:
4418:
4412:
4409:
4405:
4402:
4400:
4397:
4396:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4358:
4355:
4353:
4350:
4349:
4348:
4345:
4343:
4340:
4339:
4337:
4335:
4332:
4328:
4318:
4315:
4314:
4312:
4304:
4296:
4293:
4291:
4288:
4286:
4283:
4282:
4281:
4278:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4240:
4239:
4236:
4235:
4233:
4227:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4200:
4199:
4196:
4194:
4191:
4187:
4184:
4182:
4179:
4177:
4174:
4173:
4172:
4169:
4168:
4166:
4160:
4152:
4149:
4147:
4144:
4143:
4142:
4139:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4116:
4115:
4112:
4108:
4105:
4103:
4100:
4098:
4095:
4094:
4092:
4088:
4085:
4083:
4080:
4078:
4075:
4074:
4073:
4070:
4068:
4065:
4061:
4058:
4056:
4053:
4052:
4051:
4048:
4046:
4043:
4041:
4038:
4037:
4035:
4032:
4024:
4018:
4015:
4013:
4010:
4006:
4003:
4001:
3998:
3996:
3993:
3992:
3991:
3988:
3986:
3983:
3982:
3980:
3974:
3968:
3965:
3959:
3956:
3954:
3951:
3950:
3949:
3946:
3944:
3941:
3940:
3939:
3936:
3932:
3929:
3927:
3924:
3923:
3922:
3919:
3915:
3912:
3910:
3907:
3906:
3905:
3902:
3898:
3895:
3893:
3890:
3888:
3885:
3884:
3883:
3880:
3876:
3873:
3871:
3868:
3867:
3866:
3863:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3840:
3839:
3836:
3834:
3831:
3827:
3824:
3822:
3819:
3818:
3817:
3814:
3812:
3809:
3805:
3802:
3800:
3797:
3796:
3795:
3792:
3791:
3789:
3783:
3780:
3777:
3773:
3769:
3763:
3760:
3756:
3753:
3751:
3748:
3746:
3743:
3742:
3741:
3738:
3736:
3733:
3731:
3728:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3705:
3704:
3701:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3678:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3640:
3637:
3635:
3632:
3630:
3627:
3626:
3625:
3622:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3589:
3588:
3585:
3583:
3580:
3578:
3575:
3571:
3568:
3566:
3563:
3562:
3561:
3558:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3515:
3514:
3511:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3468:
3467:
3464:
3463:
3461:
3458:
3454:
3451:
3447:
3443:
3439:
3434:
3430:
3426:
3422:
3415:
3410:
3408:
3403:
3401:
3396:
3395:
3392:
3385:
3381:
3378:
3377:
3373:
3366:
3362:
3357:
3352:
3347:
3342:
3338:
3334:
3330:
3325:
3321:
3317:
3312:
3307:
3303:
3299:
3295:
3290:
3286:
3282:
3277:
3272:
3268:
3264:
3260:
3256:
3252:
3247:
3243:
3239:
3234:
3229:
3224:
3219:
3215:
3211:
3207:
3202:
3198:
3194:
3190:
3186:
3182:
3178:
3175:(3): 265–74.
3174:
3170:
3164:
3160:
3156:
3151:
3146:
3142:
3138:
3134:
3129:
3125:
3121:
3116:
3111:
3107:
3103:
3099:
3095:
3094:Am. J. Pathol
3091:
3086:
3082:
3078:
3073:
3068:
3064:
3060:
3056:
3051:
3047:
3043:
3039:
3035:
3034:Haematologica
3029:
3025:
3021:
3016:
3011:
3007:
3003:
3002:J. Biol. Chem
2999:
2994:
2990:
2986:
2981:
2976:
2971:
2966:
2962:
2958:
2954:
2950:
2946:
2941:
2937:
2933:
2928:
2923:
2920:(5): 309–13.
2919:
2915:
2911:
2906:
2902:
2898:
2894:
2890:
2886:
2882:
2878:
2874:
2868:
2864:
2860:
2855:
2850:
2846:
2842:
2838:
2834:
2830:
2825:
2824:
2819:
2810:
2806:
2801:
2796:
2792:
2788:
2784:
2780:
2776:
2769:
2766:
2761:
2757:
2752:
2747:
2743:
2739:
2735:
2728:
2725:
2720:
2716:
2711:
2706:
2702:
2698:
2694:
2687:
2684:
2679:
2675:
2670:
2665:
2660:
2655:
2651:
2647:
2643:
2636:
2633:
2628:
2624:
2619:
2614:
2610:
2606:
2602:
2595:
2593:
2589:
2584:
2580:
2575:
2570:
2566:
2562:
2558:
2551:
2548:
2543:
2539:
2534:
2529:
2524:
2519:
2515:
2511:
2507:
2503:
2499:
2492:
2489:
2484:
2480:
2475:
2470:
2466:
2462:
2458:
2451:
2448:
2443:
2439:
2435:
2431:
2426:
2421:
2416:
2411:
2407:
2403:
2399:
2392:
2389:
2384:
2380:
2376:
2372:
2371:Haematologica
2364:
2361:
2356:
2352:
2348:
2344:
2340:
2336:
2332:
2328:
2321:
2318:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2283:
2279:
2272:
2269:
2264:
2260:
2255:
2250:
2246:
2242:
2238:
2234:
2230:
2223:
2220:
2215:
2211:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2174:
2171:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2133:
2131:
2127:
2122:
2118:
2113:
2108:
2104:
2100:
2096:
2089:
2086:
2081:
2077:
2073:
2069:
2064:
2059:
2055:
2051:
2047:
2040:
2038:
2034:
2029:
2025:
2020:
2015:
2011:
2007:
2003:
1996:
1993:
1982:on 2020-08-14
1981:
1977:
1973:
1969:
1962:
1959:
1954:
1950:
1945:
1940:
1936:
1932:
1928:
1924:
1920:
1913:
1910:
1905:
1899:
1897:
1893:
1888:
1882:
1880:
1876:
1871:
1867:
1863:
1859:
1855:
1851:
1844:
1841:
1836:
1832:
1826:
1823:
1818:
1814:
1808:
1805:
1801:
1797:
1792:
1790:
1788:
1784:
1780:
1776:
1771:
1769:
1767:
1763:
1756:
1752:
1749:
1748:
1744:
1742:
1735:
1730:
1728:
1725:
1722:
1718:
1717:
1716:Rett syndrome
1709:
1707:
1705:
1701:
1697:
1696:
1691:
1686:
1685:instability.
1684:
1680:
1676:
1672:
1668:
1667:
1661:
1659:
1655:
1651:
1647:
1643:
1642:urinary tract
1639:
1635:
1634:advance stage
1631:
1627:
1626:
1620:
1618:
1614:
1610:
1606:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1577:
1576:breast cancer
1571:
1569:
1566:
1562:
1559:
1555:
1554:glioblastomas
1551:
1547:
1546:
1545:brain tumours
1540:
1538:
1534:
1530:
1526:
1522:
1518:
1517:
1511:
1509:
1505:
1504:
1500:
1493:
1491:
1487:
1483:
1478:
1477:
1476:breast cancer
1472:
1471:
1466:
1462:
1461:
1457:
1456:
1451:
1447:
1439:
1437:
1435:
1431:
1427:
1422:
1417:
1415:
1411:
1407:
1406:endometriosis
1403:
1402:pathogenicity
1400:
1392:
1387:
1385:
1383:
1380:, GRRP1, and
1379:
1375:
1371:
1366:
1363:
1358:
1356:
1352:
1348:
1344:
1340:
1336:
1332:
1329:
1325:
1324:proliferation
1321:
1316:
1314:
1310:
1306:
1302:
1298:
1295:
1294:telencephalic
1291:
1287:
1283:
1280:
1276:
1271:
1269:
1265:
1261:
1257:
1253:
1252:embryogenesis
1245:
1243:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1214:
1213:Transcription
1210:
1208:
1204:
1200:
1196:
1187:
1185:
1183:
1179:
1175:
1171:
1170:transcription
1167:
1159:
1157:
1155:
1151:
1147:
1143:
1139:
1135:
1131:
1130:tumorigenesis
1127:
1123:
1119:
1115:
1103:
1098:
1094:
1090:
1087:
1083:
1076:
1074:
1071:
1067:
1063:
1059:
1056:
1052:
1048:
1041:
1039:
1033:
1029:
1026:
1020:
1018:
1012:
1008:
1005:
1001:
994:
992:
986:
982:
979:
973:
971:
965:
961:
958:
956:RefSeq (mRNA)
954:
947:
946:
941:
937:
934:
928:
927:
922:
918:
915:
913:
909:
902:
901:
896:
892:
889:
883:
882:
877:
873:
870:
868:
864:
857:
856:
851:
847:
844:
838:
837:
832:
828:
825:
823:
819:
816:
813:
811:
808:
804:
801:
797:
793:
786:
782:
777:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
622:
620:
617:
616:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
560:
558:
555:
554:
551:
550:Gene ontology
547:
543:
531:
526:
522:
515:
508:
503:
500:
498:
494:
486:
481:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
408:
404:
401:thyroid gland
400:
396:
393:hair follicle
392:
388:
384:
380:
377:skin of thigh
376:
372:
371:
368:
364:
359:
356:
355:
352:
350:
346:
344:
343:
339:
338:
335:
333:
329:
325:
321:
317:
309:
304:
300:
296:
291:
281:
277:
270:
263:
257:
250:
242:
238:
234:
229:
225:
220:
216:
208:
203:
199:
195:
190:
180:
176:
169:
162:
156:
149:
145:
139:
135:
131:
126:
122:
117:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
73:
65:
60:
53:
48:
43:
39:
34:
29:
25:
23:
8834:
8833:
8821:
8776:
8732:
8690:
8682:
8654:
8648:
8642:
8611:
8576:
8564:
8501:
8478:
8460:
8428:
8399:
8280:
8210:
8184:
8136:
8039:
7986:
7906:
7894:
7848:
7840:
7746:
7692:
7665:
7657:
7628:
7617:
7361:FOX proteins
7321:winged helix
7313:
7284:
7267:
7210:
7130:
7104:
6982:
6948:
6931:
6909:
6892:
6825:
6793:
6647:
6610:
6591:
6537:
6503:
6497:
6191:
6185:
6174:
6168:Antennapedia
6166:
6153:
6141:
6135:
6104:
6062:
6040:
6017:
5996:
5754:
5707:
5653:
5599:
5512:
5490:
5468:
5446:
5429:
5387:
5316:
5198:
5166:
5118:
5090:
5070:
5045:
5008:
4974:Progesterone
4927:
4823:
4671:
4657:
4651:
4635:
4577:
4530:
4522:
4420:
4330:
4279:
4237:
4217:
4197:
4170:
4140:
4113:
3947:
3937:
3920:
3903:
3815:
3771:
3739:
3702:
3559:
3449:
3437:
3336:
3332:
3301:
3297:
3258:
3254:
3213:
3209:
3172:
3168:
3140:
3136:
3097:
3093:
3062:
3058:
3037:
3033:
3005:
3001:
2955:(1): 130–5.
2952:
2948:
2917:
2913:
2876:
2872:
2836:
2832:
2782:
2778:
2768:
2741:
2737:
2727:
2700:
2696:
2686:
2649:
2645:
2635:
2608:
2604:
2564:
2560:
2550:
2505:
2501:
2491:
2464:
2460:
2450:
2405:
2401:
2391:
2374:
2370:
2363:
2330:
2326:
2320:
2285:
2281:
2271:
2239:(1): 51–54.
2236:
2232:
2222:
2187:
2183:
2173:
2146:
2142:
2102:
2098:
2088:
2053:
2049:
2009:
2005:
1995:
1984:. Retrieved
1980:the original
1975:
1971:
1961:
1926:
1922:
1912:
1856:(1): 200–3.
1853:
1849:
1843:
1834:
1825:
1816:
1807:
1739:
1714:
1713:
1693:
1687:
1664:
1662:
1646:renal pelvis
1623:
1621:
1619:epithelium.
1574:
1572:
1552:tumours and
1543:
1541:
1514:
1512:
1499:B lymphocyte
1496:
1494:
1474:
1469:
1464:
1459:
1454:
1443:
1418:
1396:
1359:
1317:
1272:
1249:
1211:
1207:heterodimers
1191:
1163:
1154:angiogenesis
1148:, and as an
1113:
1112:
1035:
1014:
988:
967:
943:
924:
898:
879:
853:
834:
814:
809:
463:aortic valve
347:
340:
67:External IDs
21:
8502:(4.11) Runt
6157:Homeodomain
5755:zinc finger
5091:subfamily 0
5071:subfamily 6
5046:subfamily 5
5009:subfamily 4
4928:subfamily 3
4824:subfamily 2
4672:subfamily 1
4639:Zinc finger
3882:Neurogenins
3450:(1.1) Basic
3304:(1): 15–8.
3210:Mol. Cancer
3167:leukemia".
2143:Development
1700:risk factor
1669:. The ID4
1609:ER negative
1601:ER positive
1589:risk factor
1470:endometrial
1355:neural tube
1351:hippocampus
1331:progenitors
1205:by forming
1178:amino acids
1168:and during
443:optic nerve
389:optic nerve
373:skin of hip
306:48,419,502
293:48,414,704
205:19,842,197
192:19,837,370
45:Identifiers
24:(1996 film)
8851:Categories
7035:POU domain
6175:ANTP class
6105:(2.6) WRKY
5388:GLI family
4523:(1.5) RF-X
4421:(1.4) NF-1
3333:BMC Cancer
3169:Nat. Genet
2652:(16): 16.
1986:2018-06-07
1802:, May 2017
1781:, May 2017
1757:References
1638:urothelium
1593:metastasis
1581:carcinomas
1565:neoplastic
1561:astrocytes
1558:neoplastic
1527:, diffuse
1519:, the ID4
1434:chromosome
1343:cell cycle
1313:epithelium
1288:, and the
1282:myocardium
1138:senescence
351:(ortholog)
88:HomoloGene
8822:see also
8663:Apetala 2
7317:Fork head
5997:(2.4) Cys
5199:(2.3) Cys
3931:Scleraxis
3216:(1): 16.
2425:2381/4129
1704:prognosis
1702:for poor
1613:oestrogen
1591:in nodal
1585:specimens
1399:molecular
1335:stem cell
1326:in early
1260:gestation
1160:Structure
1146:apoptosis
1038:NP_112443
1017:NP_001537
991:NM_031166
970:NM_001546
800:Orthologs
604:cytoplasm
96:GeneCards
8140:MADS box
6280:Homeobox
6192:Hox-like
6186:protoHOX
4947:Estrogen
4942:Androgen
4796:Rev-ErbA
4334:bHLH-ZIP
4309:bHLH-COE
3848:Myogenin
3365:18513385
3320:17510533
3285:16682435
3242:15876350
3189:15723065
3159:15569977
3124:14633621
3081:14534543
3059:Oncogene
3046:12969807
3024:11756408
2989:11136250
2901:23855715
2809:16682435
2760:15897910
2738:Oncogene
2719:14534543
2697:Oncogene
2678:15876350
2627:16687485
2583:16963729
2542:15827123
2483:18371409
2434:17940204
2383:12969807
2347:14631357
2312:22896676
2263:21151130
2214:28794185
2165:15469968
2080:16707840
2072:11731247
1850:Genomics
1798:–
1777:–
1745:See also
1721:X linked
1690:adenomas
1630:amplicon
1533:lymphoid
1497:B-Cell (
1365:mesoderm
1328:cortical
1305:neuronal
1297:vesicles
1290:tail bud
1286:mesoderm
1188:Function
1150:oncogene
1086:Wikidata
779:Sources:
8540:RUNX1T1
8520:CBFA2T3
8515:CBFA2T2
8395:TCF/LEF
6504:NK-like
6498:metaHOX
6201:ParaHox
6142:domains
4833:COUP-TF
4307:Group F
4230:Group E
4163:Group D
4027:Group C
3977:Group B
3921:Paraxis
3786:Group A
3356:2435120
3339:: 154.
3276:1931415
3233:1131921
3115:1892385
2957:Bibcode
2936:9872455
2914:DNA Res
2893:9418957
2863:8759016
2800:1931415
2669:1131921
2510:Bibcode
2442:3181091
2355:3345120
2303:3633234
2254:3019124
2205:5580654
2121:8922523
2028:9516472
1953:8139914
1870:7665172
1800:Ensembl
1779:Ensembl
1658:urethra
1654:bladder
1650:ureters
1605:lesions
1597:mammary
1465:ovarian
1455:primary
1362:cardiac
1309:ventral
1264:central
1216:factors
1201:(bHLH)
1120:coding
1118:protein
912:UniProt
867:Ensembl
806:Species
785:QuickGO
609:nucleus
471:utricle
397:urethra
326:pattern
52:Aliases
7253:Bicoid
6518:BARHL2
6513:BARHL1
6095:JMJD1B
6008:HIVEP1
4493:I-SMAD
4461:R-SMAD
4379:MLXIPL
4134:Period
4060:ARNTL2
3865:NeuroD
3386:(MeSH)
3363:
3353:
3318:
3283:
3273:
3240:
3230:
3197:515916
3195:
3187:
3157:
3122:
3112:
3079:
3044:
3022:
2987:
2977:
2934:
2899:
2891:
2861:
2854:145994
2851:
2807:
2797:
2758:
2717:
2676:
2666:
2625:
2581:
2540:
2533:556127
2530:
2481:
2440:
2432:
2381:
2353:
2345:
2310:
2300:
2261:
2251:
2212:
2202:
2163:
2119:
2078:
2070:
2026:
1951:
1944:307878
1941:
1868:
1719:is an
1490:vagina
1486:cervix
1482:uterus
1414:CDKN1A
1347:cortex
1279:dorsal
1277:, the
1224:dimers
1072:search
1070:PubMed
945:P41139
926:P47928
822:Entrez
497:BioGPS
184:6p22.3
76:600581
8803:Sigma
8668:EREBP
8652:EREBP
8643:(0.5)
8612:(0.3)
8535:RUNX3
8530:RUNX2
8525:RUNX1
8469:TFCP2
8390:SSRP1
8211:(4.7)
8201:TBPL1
8185:(4.6)
8137:(4.4)
7987:(4.2)
7928:NFKB2
7923:NFKB1
7918:NF-κB
7907:(4.1)
7831:MYBL2
7618:(3.4)
7314:(3.3)
7263:BICD2
7238:SHOX2
7206:PROP1
7190:PRRX
7100:SATB2
7045:BRN-3
7040:PIT-1
6932:PKNOX
6847:TALE
6843:NOBOX
6816:HESX1
6789:CUTL1
6771:other
6665:NANOG
6528:BARX2
6523:BARX1
6275:MEOX2
6270:MEOX1
6154:(3.1)
6063:JARID
6036:GRLF1
6031:DIDO1
5691:Zbtb7
5681:TSHZ3
5649:PRDM9
5447:HIVEP
5312:ATBF1
5266:TFIIH
5251:TFIIF
5234:TFIIE
5229:TFIID
5224:TFIIB
5219:TFIIA
5189:TRPS1
5055:LRH-1
5033:NURR1
5023:NGFIB
4851:Ear-2
4652:(2.1)
4394:SREBP
4331:(1.3)
4093:NPAS
4082:EPAS1
4067:CLOCK
4055:ARNTL
4029:bHLH-
4005:n-Myc
4000:l-Myc
3995:c-Myc
3985:FIGLA
3967:Twist
3926:TCF15
3833:MESP2
3811:ATOH1
3804:ASCL2
3799:ASCL1
3730:NFIL3
3661:GABPA
3656:DDIT3
3587:C/EBP
3582:BLZF1
3543:c-Jun
3533:FOSL2
3528:FOSL1
3518:c-Fos
3193:S2CID
2980:14556
2897:S2CID
2438:S2CID
2402:Blood
2351:S2CID
2076:S2CID
1446:ovary
1410:HOXA9
1382:MESP1
1374:FOXA2
1166:exons
1116:is a
855:15904
815:Mouse
810:Human
781:Amigo
349:Mouse
342:Human
289:Start
224:Mouse
188:Start
121:Human
84:99414
8772:MNDA
8691:ARID
8646:AP-2
8633:RBL2
8628:RBL1
8602:HBP1
8585:HMGA
8492:YBX1
8487:CSDA
8422:LEF1
8254:HMGN
8227:HMGB
8148:Mef2
8127:MYRF
8115:TBR2
8110:TBR1
8058:TP63
7998:STAT
7990:STAT
7950:NFAT
7943:RELB
7938:RELA
7893:(4)
7774:FLI1
7740:SPIB
7441:D4L6
7436:D4L5
7431:D4L4
7426:D4L3
7421:D4L1
7285:PITX
7248:VSX2
7243:VSX1
7233:SHOX
7211:PHOX
6893:MEIS
6821:HOPX
6757:VAX2
6752:VAX1
6747:TLX3
6742:TLX2
6737:TLX1
6732:NATO
6715:HMX3
6710:HMX2
6705:HMX1
6643:LBX2
6638:LBX1
6628:HHEX
6487:MNX1
6482:GBX2
6477:GBX1
6265:Evx2
6260:Evx1
6228:PDX1
6223:Xlox
6113:WRKY
6026:AIRE
5985:804A
5708:ZBTB
5654:SALL
5644:OSR1
5639:MYT1
5634:MTF1
5469:IKZF
5408:REST
5383:GFI1
5378:ERV3
5346:E4F1
5341:CTCF
5130:GATA
5100:DAX1
5080:GCNF
5028:NOR1
4856:HNF4
4725:PPAR
4658:(Cys
4586:AP-2
4456:SMAD
4411:USF1
4384:MXI1
4364:MITF
4357:MXD3
4352:MXD1
4342:AP-4
4317:EBF1
4193:Pho4
4171:BHLH
4050:ARNT
4045:AHRR
4017:TCF4
4012:MXD4
3943:LYL1
3904:OLIG
3858:MYF6
3853:MYF5
3843:MyoD
3816:HAND
3794:AS-C
3776:bHLH
3762:XBP1
3666:GCN4
3646:CREM
3624:CREB
3577:BATF
3560:BACH
3553:JunD
3548:JUNB
3538:JDP2
3523:FOSB
3513:AP-1
3471:AATF
3457:bZIP
3423:and
3361:PMID
3316:PMID
3281:PMID
3238:PMID
3185:PMID
3155:PMID
3120:PMID
3077:PMID
3042:PMID
3020:PMID
2985:PMID
2932:PMID
2889:PMID
2859:PMID
2805:PMID
2756:PMID
2715:PMID
2674:PMID
2623:PMID
2579:PMID
2538:PMID
2479:PMID
2430:PMID
2379:PMID
2343:PMID
2308:PMID
2259:PMID
2210:PMID
2161:PMID
2117:PMID
2068:PMID
2024:PMID
1949:PMID
1866:PMID
1531:and
1488:and
1473:and
1448:and
1430:loci
1412:and
1378:EVX1
1372:and
1370:TCF3
1349:and
1320:G1-S
1299:and
1266:and
1254:and
1174:mRNA
1172:its
1128:and
1122:gene
836:3400
332:Bgee
280:Band
241:Chr.
179:Band
138:Chr.
92:1186
72:OMIM
8799:Rho
8777:NFY
8750:MLL
8733:IFI
8728:CAP
8510:CBF
8429:TOX
8400:TCF
8385:SRY
8298:SOX
8281:HNF
8222:BBX
8196:TBP
8175:SRF
8120:TFT
8070:TBX
8063:p73
8053:p53
7933:REL
7826:MYB
7747:ETV
7735:ERG
7720:ETS
7715:ERF
7693:ELK
7688:EGF
7666:ELF
7630:HSF
7329:E2F
7268:OTX
7258:GSC
7228:RAX
7139:PAX
7105:ZEB
7078:3/4
7028:21A
6983:PHF
6949:SIX
6910:PBX
6886:MKX
6851:IRX
6826:LMX
6794:FHL
6784:CRX
6779:ARX
6725:6-2
6720:6-1
6700:3-2
6695:3-1
6690:2-5
6685:2-3
6680:2-2
6675:2-1
6670:NKX
6648:MSX
6633:HLX
6593:EMX
6555:DLX
6538:DBX
6533:BSX
6470:D13
6465:D12
6460:D11
6455:D10
6425:C13
6420:C12
6415:C11
6410:C10
6380:B13
6330:A13
6325:A11
6320:A10
6235:Cdx
6206:Gsx
6136:(3)
6041:ING
5980:655
5975:649
5970:644
5965:638
5960:593
5955:471
5950:452
5945:451
5940:423
5935:384
5930:366
5925:365
5920:350
5915:346
5910:330
5905:318
5900:300
5895:281
5890:268
5885:267
5880:259
5875:239
5870:238
5865:219
5860:217
5855:202
5850:165
5845:148
5840:146
5835:143
5795:33B
5686:WT1
5513:KLF
5491:ILF
5430:HIC
5423:YY1
5351:EGR
5334:11B
5329:11A
5318:BCL
5301:3C2
5296:3C1
5203:His
5167:MTA
5105:SHP
5060:SF1
5018:NUR
4917:TLX
4878:RXR
4873:PNR
4813:VDR
4774:ROR
4752:RAR
4747:PXR
4735:β/δ
4708:LXR
4703:FXR
4698:CAR
4636:(2)
4566:ANK
4531:RFX
4429:NFI
4389:Myc
4374:MLX
4369:MNT
4347:MAX
4280:HEY
4238:HES
4141:SIM
4114:PER
4072:HIF
4040:AhR
4031:PAS
3990:Myc
3948:TAL
3938:SLC
3740:NRF
3735:NRL
3703:NFE
3676:MAF
3671:HLF
3651:DBP
3351:PMC
3341:doi
3306:doi
3271:PMC
3263:doi
3228:PMC
3218:doi
3177:doi
3145:doi
3110:PMC
3102:doi
3098:163
3067:doi
3010:doi
3006:277
2975:PMC
2965:doi
2922:doi
2881:doi
2849:PMC
2841:doi
2795:PMC
2787:doi
2746:doi
2705:doi
2664:PMC
2654:doi
2613:doi
2569:doi
2528:PMC
2518:doi
2506:102
2469:doi
2420:hdl
2410:doi
2406:111
2335:doi
2298:PMC
2290:doi
2249:PMC
2241:doi
2200:PMC
2192:doi
2151:doi
2147:131
2107:doi
2103:207
2058:doi
2054:109
2014:doi
2010:273
1939:PMC
1931:doi
1858:doi
1692:of
1607:.
1542:In
1513:In
1508:IgH
1495:In
1428:at
1404:of
1384:).
1339:RB1
1238:by
1152:in
1114:ID4
302:End
201:End
104:OMA
100:ID4
80:MGI
59:ID4
36:ID4
8853::
8765:T1
8743:35
8738:16
8721:4A
8716:3B
8711:3A
8701:1B
8696:1A
8673:B3
8623:Rb
8378:21
8373:18
8368:15
8363:14
8358:13
8353:12
8348:11
8343:10
8291:1B
8286:1A
8105:22
8100:21
8095:19
7970:C4
7965:C3
7960:C2
7955:C1
7606:S1
7601:R2
7596:R1
7591:Q1
7586:P4
7581:P3
7576:P2
7571:P1
7566:O6
7561:O4
7556:O3
7551:O1
7546:N4
7541:N3
7536:N2
7531:N1
7526:M1
7521:L2
7516:L1
7511:K2
7506:K1
7501:J3
7496:J2
7491:J1
7486:I3
7481:I2
7476:I1
7471:H1
7466:G1
7461:F2
7456:F1
7451:E3
7446:E1
7416:D4
7411:D3
7406:D2
7401:D1
7396:C2
7391:C1
7386:B2
7381:B1
7376:A3
7371:A2
7366:A1
7319:/
7221:2B
7216:2A
7093:11
7066::
7047::
7023:20
7018:17
7013:16
7008:10
6836:1B
6831:1A
6611:EN
6450:D9
6445:D8
6440:D4
6435:D3
6430:D1
6405:C9
6400:C8
6395:C6
6390:C5
6385:C4
6375:B9
6370:B8
6365:B7
6360:B6
6355:B5
6350:B4
6345:B3
6340:B2
6335:B1
6315:A9
6310:A7
6305:A5
6300:A4
6295:A3
6290:A2
6285:A1
6083:1D
6078:1C
6073:1B
6068:1A
5830:74
5825:51
5820:44
5815:43
5810:41
5805:35
5800:34
5790:24
5785:22
5780:19
5775:10
5748:40
5743:33
5738:32
5733:21
5728:20
5723:17
5718:16
5713:11
5701:7B
5696:7A
5600:SP
5593:17
5588:15
5583:14
5578:13
5573:12
5568:11
5563:10
5418:S2
5413:S1
5291:3A
5286:2I
4844:II
4198:ID
4087:3A
4077:1A
3723:L3
3718:L2
3713:L1
3639:L1
3359:.
3349:.
3335:.
3331:.
3314:.
3302:47
3300:.
3296:.
3279:.
3269:.
3259:15
3257:.
3253:.
3236:.
3226:.
3212:.
3208:.
3191:.
3183:.
3173:37
3171:.
3153:.
3141:10
3139:.
3135:.
3118:.
3108:.
3096:.
3092:.
3075:.
3063:22
3061:.
3057:.
3038:88
3036:.
3018:.
3004:.
3000:.
2983:.
2973:.
2963:.
2953:98
2951:.
2947:.
2930:.
2916:.
2912:.
2895:.
2887:.
2877:50
2875:.
2857:.
2847:.
2837:24
2835:.
2831:.
2803:.
2793:.
2783:15
2781:.
2777:.
2754:.
2742:24
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2736:.
2713:.
2701:22
2699:.
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2662:.
2648:.
2644:.
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2607:.
2603:.
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2577:.
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2329:.
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2247:.
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2235:.
2231:.
2208:.
2198:.
2188:31
2186:.
2182:.
2159:.
2145:.
2141:.
2129:^
2115:.
2101:.
2097:.
2074:.
2066:.
2052:.
2048:.
2036:^
2022:.
2008:.
2004:.
1974:.
1970:.
1947:.
1937:.
1927:22
1925:.
1921:.
1895:^
1878:^
1864:.
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1852:.
1833:.
1815:.
1786:^
1765:^
1652:,
1648:,
1570:.
1539:.
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1492:.
1484:,
1467:,
1419:A
1226:.
1156:.
1144:,
1140:,
1136:,
783:/
308:bp
295:bp
207:bp
194:bp
102:;
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8801:/
8792:C
8787:B
8782:A
8760:3
8755:2
8706:2
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8595:2
8590:1
8449:4
8444:3
8439:2
8434:1
8415:4
8410:3
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8328:6
8323:5
8318:4
8313:3
8308:2
8303:1
8274:4
8269:3
8264:2
8259:1
8247:4
8242:3
8237:2
8232:1
8168:D
8163:C
8158:B
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8090:5
8085:3
8080:2
8075:1
8028:6
8023:5
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7869:4
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