267:
244:
141:
166:
532:
525:
518:
273:
172:
1388:
function in frog embryos and human embryonic stem cells. Ablation of the ID gene family mouse embryos showed failure of anterior cardiac progenitor specification and the development of heartless embryos. This study also demonstrated that ID4 protein is involved in the regulating cardiac cell fate by
3187:
Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu YZ, Raval A, Liu TH, Ding W, Mao C, Liu S, Smith LT, Lee S, Rassenti L, Marcucci G, Byrd J, Caligiuri MA, Plass C (2005). "Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human
1761:
The ID4 gene is also known as DNA-binding protein inhibitor ID-4, Id-4, IDb4, IDB4, Inhibitor of DNA binding 4, Inhibitor of differentiation 4, helix protein 271, Inhibitor of DNA binding 4 HLH Protein, Inhibitor of
Differentiation 4, Inhibitor of DNA Binding 4 Dominant Negative Helix-Loop-Helix
1989:"Mutually exclusive expression of two dominant-negative helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing brain of the mouse suggests distinct regulatory roles of these dnHLH proteins during cellular proliferation and differentiation of the nervous system"
2389:
Bellido M, Aventín A, Lasa A, Estivill C, Carnicer MJ, Pons C, Matías-Guiu X, Bordes R, Baiget M, Sierra J, Nomdedéu JF (September 2003). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia".
2891:
Stewart HJ, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave KA, Mirsky R, Jessen KR (1998). "Helix-loop-helix proteins in
Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development".
3052:
Bellido M, Aventín A, Lasa A, Estivill C, Carnicer MJ, Pons C, Matías-Guiu X, Bordes R, Baiget M, Sierra J, Nomdedéu JF (2004). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia".
1500:
cell lines. The mechanism behind this is believed to be that ID4 regulates HOXA9 and CDKN1A genes, which are mediators of cell proliferation and differentiation. HOXA genes are known to play a role in the differentiation of fallopian tubes,
3432:
1747:
disorder. It is often identified after six to eight months of age in females. In human brain tissue specimens of Rett syndrome patients, the family of ID genes are seen to be significantly increased in expression.
1444:
revealed over 100 candidate genes associated with endometriosis. Of these, six were shown to have a highly reliable association, of which the ID4 gene was identified. This is thought to be due to an independent
1209:
gene is part of the ID gene family. This family is also known as inhibitors of DNA binding protein family and are composed of transcription inhibitory proteins which modulate a number of processes. They are
3425:
4354:
2417:
Russell LJ, Akasaka T, Majid A, Sugimoto KJ, Loraine Karran E, Nagel I, Harder L, Claviez A, Gesk S, Moorman AV, Ross F, Mazzullo H, Strefford JC, Siebert R, Dyer MJ, Harrison CJ (Jan 2008).
8844:
3418:
4853:
1869:
Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22".
1137:. In humans, it encodes the protein known as DNA-binding protein inhibitor ID-4. This protein is known to be involved in the regulation of many cellular processes during both
7060:
1457:
6p22.3. ID4 is implicated in the molecular pathogenicity of endometriosis as being differentially expressed between the proliferative, early and mid-secretory phases.
5738:
4760:
4755:
4750:
280:
179:
4399:
4384:
4070:
2476:
Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T (December 2007).
4893:
8688:
8672:
3491:
8857:
4745:
1374:. This is integral to normal brain size formation. ID4 regulates neural progenitor proliferation and differentiation. Its expression is seen in the
865:
846:
102:
4530:
4523:
4518:
4506:
4501:
4496:
4491:
4486:
4414:
8410:
5209:
4268:
1657:
bladder cancer. ID4 has also been shown to be overexpressed in bladder cancer cell lines. This overexpression is equally seen in both normal
1851:
1833:
8877:
1235:
containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems.
266:
8173:
4065:
3637:
2905:
8442:
7341:
5428:
2132:
2115:
1702:. There is an undefined but significant association seen in ID4 promoter hypermethylation (which results in its down regulation) and
1632:
carcinomas also show ID4 expression. There is a hypothesis that ID4 acts as a tumour suppressor factory in human breast tissue where
1072:
1065:
243:
4886:
4881:
4809:
4799:
3676:
3666:
3501:
2517:
Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA (April 2005).
1294:
ID4 expression has been shown to be discrete in the early stages, with transcription transiently expressed in subsets of migrating
4804:
4718:
1907:
1771:
1197:
motif from amino acid 65 to 105 and a poly-Pro region from amino acid 118 to 124. This protein is expressed in various tissues.
7740:
5016:
5006:
3607:
3486:
2419:"t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)"
1820:
1799:
1317:
3272:"Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome"
2964:
Beger C, Pierce LN, Kruger M, Marcusson EG, Robbins JM, Welcsh P, Welch PJ, Welte K, King MC, Barber JR, Wong-Staal F (2001).
8882:
5371:
5011:
4706:
1988:
1446:
1816:
2796:"Inhibitors of differentiation (ID1, ID2, ID3, ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome"
165:
140:
8653:
8648:
7799:
4711:
2850:"E2A basic helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein"
1523:
1441:
1795:
1247:(antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the
8748:
7084:
5234:
4787:
4777:
3154:"Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis"
1291:. ID4 transcription control has both negative and positive regulatory elements inclusive of novel inhibitory functions.
82:
31:
3111:"Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas"
2478:"Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche"
7253:
7248:
6799:
4876:
4794:
4782:
3858:
2966:"Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach"
2116:"Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis"
1940:"The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3"
3019:"Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation"
2023:"A role for Sp and helix-loop-helix transcription factors in the regulation of the human Id4 gene promoter activity"
4989:
3987:
2755:"Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer"
1528:
1211:
279:
178:
8405:
5286:
5271:
5254:
5249:
5244:
5239:
5150:
5125:
5001:
4913:
4903:
4060:
3533:
1288:
3350:"Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer"
1719:. Hypermethylation of ID4 causes silencing of the gene. This has been identified as a significant independent
1358:
proliferation and differentiation by inhibiting proliferation of differentiating neurons through enhancement of
272:
171:
8147:
7782:
7298:
6871:
6710:
5645:
5640:
5625:
5100:
5075:
4957:
4908:
4701:
4092:
3558:
3404:
1229:
1154:
910:
90:
2621:
1362:-mediated pathways. This is either by direct interaction or through interaction with other molecules of the
8512:
6553:
5870:
4984:
4972:
2622:"Methylation of p16 and Ras Association Domain Family Protein 1a during Colorectal Malignant Transformation"
2519:"TGene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme"
2346:
Kobayashi A, Behringer RR (Dec 2003). "Developmental genetics of the female reproductive tract in mammals".
1429:. These pathways are still poorly understood. It is thought that ID4 plays a role in the transcription of
1182:
891:
8643:
6690:
6685:
5080:
4977:
4772:
4733:
3796:
3445:
1727:
of colorectal cancer. It is also frequently observed in liver metastases of colorectal cancer specimens.
1578:
1284:
1215:
8635:
8195:
4994:
4930:
4925:
4738:
3814:
1219:
1698:
and frequently expressed in gastric cancer cell lines. In contrast, ID4 is highly expressed in normal
8216:
8208:
6046:
5528:
5053:
5048:
5043:
4723:
4606:
3441:
2977:
2530:
1536:
1232:
1138:
154:
3410:
69:
8530:
8234:
7930:
6133:
5338:
4920:
4898:
4871:
4833:
4767:
1605:
1545:
1366:
machinery. ID4 also regulates the lateral expansion of the proliferative zone in the developing
1236:
2712:
Chan AS, Tsui WY, Chen X, Chu KM, Chan TL, Chan AS, Li R, So S, Yuen ST, Leung SY (October 2003).
2299:"Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4"
2248:
Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Zondervan KT, et al. (2011).
8068:
3213:
2917:
2576:
Umetani N, Giuliano AE, Hiramatsu SH, Amersi F, Nakagawa T, Martino S, Hoon DS (September 2006).
2458:
2371:
2096:
1489:
1344:
1321:
1295:
1256:
1248:
114:
3400:
1244:
1048:
1027:
1001:
980:
1924:
7650:
7641:
7278:
6226:
4967:
4962:
3381:
3336:
3301:
3258:
3205:
3175:
3140:
3097:
3062:
3040:
3005:
2952:
2909:
2879:
2825:
2776:
2735:
2694:
2643:
2599:
2558:
2499:
2450:
2399:
2363:
2328:
2279:
2230:
2181:
2137:
2088:
2044:
1969:
1886:
1715:
1367:
1276:
62:
7461:
7456:
7451:
7446:
7441:
6533:
6177:
6159:
4728:
4675:
4449:
3371:
3361:
3326:
3291:
3283:
3248:
3238:
3197:
3165:
3130:
3122:
3087:
3030:
2995:
2985:
2942:
2901:
2869:
2861:
2815:
2807:
2766:
2725:
2684:
2674:
2633:
2589:
2548:
2538:
2489:
2440:
2430:
2355:
2318:
2310:
2269:
2261:
2220:
2212:
2171:
2127:
2078:
2034:
1959:
1951:
1878:
1744:
1588:
1557:
1450:
1348:
1299:
1194:
359:
290:
234:
189:
7621:
7616:
7566:
7556:
7536:
7521:
7501:
7426:
7406:
6548:
6543:
531:
8318:
7541:
7411:
6777:
6735:
6730:
6725:
6663:
6575:
6497:
6285:
6236:
6231:
4278:
3074:
Chan AS, Tsui WY, Chen X, Chu KM, Chan TL, Chan AS, Li R, So S, Yuen ST, Leung SY (2003).
2250:"Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis"
2067:"ID4 expression and its relationship to other ID genes during avian embryonic development"
1695:
1691:
1570:
1549:
1541:
1470:
1252:
334:
38:
3348:
Noetzel E, Veeck J, Niederacher D, Galm O, Horn F, Hartmann A, Knüchel R, Dahl E (2008).
2929:
Rigolet M, Rich T, Gross-Morand MS, Molina-Gomes D, Viegas-Pequignot E, Junien C (1999).
1908:"Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein"
110:
2981:
2534:
1594:
The ID4 promoter region has been found to be hypermethylated and its mRNA suppressed in
524:
517:
8415:
6695:
6678:
4821:
4476:
3473:
3376:
3349:
3296:
3271:
3253:
3226:
3135:
3110:
2820:
2795:
2689:
2662:
2323:
2298:
2274:
2249:
2225:
2200:
1703:
1699:
1686:
1654:
1645:
1479:
3126:
2931:"cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene"
2874:
2849:
2578:"Prediction of breast tumor progression by integrity of free circulating DNA in serum"
2553:
2518:
2083:
2066:
1964:
1939:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
619:
614:
598:
593:
588:
583:
578:
573:
8871:
8861:
7273:
6613:
5038:
4826:
4154:
3000:
2965:
2753:
Umetani N, Mori T, Koyanagi K, Shinozaki M, Kim J, Giuliano AE, Hoon DS (July 2005).
1736:
1662:
1637:
1596:
1574:
1496:
1474:
1426:
1422:
1314:
1272:
1240:
1146:
1142:
560:
2921:
2100:
1226:. The heterodimer is what inhibits their DNA binding and transcriptional activity.
8823:
8135:
8018:
8010:
7381:
7337:
6340:
6188:
2462:
2375:
1666:
1519:
1223:
1166:
352:
131:
3217:
3170:
3153:
2638:
2000:
94:
3315:"Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma"
2435:
2314:
1271:
gene plays a pivotal role in development and is a key player in many pathways of
118:
8507:
8110:
6590:
6305:
6270:
4659:
4464:
4459:
3902:
3706:
3701:
3597:
3477:
2418:
1856:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1838:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1720:
1629:
1621:
1609:
1565:
1375:
1371:
1351:
1190:
2523:
Proceedings of the
National Academy of Sciences of the United States of America
2494:
2477:
435:
8819:
8770:
8242:
7846:
7755:
7735:
7708:
7055:
6804:
6653:
6641:
6636:
5635:
5630:
4394:
4389:
4367:
4233:
4051:
3755:
3696:
3691:
3671:
3227:"Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer"
3076:"Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma"
2714:"Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma"
2663:"Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer"
2620:
Umetani N, de Maat MG, Sunami E, Hiramatsu S, Martinez S, Hoon DB (May 2006).
1658:
1613:
1601:
1581:
1553:
1454:
1363:
1333:
1302:
1279:. ID4 expression is upregulated in embryogenesis during days 9.5 and 13.5 of
1150:
251:
148:
98:
2947:
2930:
2865:
2594:
2577:
1600:
cell lines including that of primary breast cancers. Patients with invasive
1527:(B-ALL), ID4 is overexpressed due to being located in close proximity to the
8693:
8683:
8666:
8140:
7159:
4864:
4293:
3951:
3366:
3152:
Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ, Hoon DS (2005).
2543:
2039:
2022:
1724:
1419:
1389:
a pathway which represses two inhibitors of cardiogenic mesoderm formation (
1355:
1280:
1158:
810:
495:
373:
318:
305:
217:
204:
106:
3385:
3340:
3305:
3262:
3243:
3209:
3179:
3144:
3101:
3092:
3075:
3066:
3044:
3035:
3018:
3009:
2829:
2780:
2771:
2754:
2739:
2730:
2713:
2698:
2679:
2647:
2603:
2562:
2503:
2454:
2403:
2367:
2332:
2283:
2234:
2216:
2185:
2160:"Id4 regulates neural progenitor proliferation and differentiation in vivo"
2092:
1955:
1882:
2990:
2956:
2913:
2906:
10.1002/(SICI)1097-4547(19971201)50:5<684::AID-JNR6>3.0.CO;2-D
2883:
2141:
2048:
1973:
1890:
1193:, is 16.6 KDa and contains a poly-Ala segment from amino acid 39 to 48, a
1112:
1107:
17:
8160:
7938:
6300:
4859:
4816:
3868:
3287:
2811:
2133:
10.1002/(SICI)1097-0177(199611)207:3<235::AID-AJA1>3.0.CO;2-I
1741:
1650:
1633:
1585:
1385:
1325:
1310:
1306:
1162:
1096:
955:
936:
3331:
3314:
8560:
8540:
8535:
8247:
6221:
6005:
3917:
3912:
3907:
3895:
3890:
1710:
1678:
1674:
1670:
1625:
1617:
1382:
1329:
1251:. Consequently, ID proteins inhibit binding to DNA and transcriptional
1130:
922:
877:
2176:
2159:
8741:
8736:
8731:
8721:
8716:
8435:
7990:
7985:
7980:
7975:
7241:
7236:
7113:
7108:
7103:
7088:
7079:
7074:
7069:
7048:
6962:
6957:
6745:
6740:
6720:
6715:
6705:
6700:
6538:
6490:
6485:
6480:
6475:
6445:
6440:
6435:
6430:
6400:
6350:
6345:
6108:
6028:
6000:
5995:
5990:
5985:
5980:
5975:
5970:
5965:
5960:
5955:
5950:
5945:
5940:
5935:
5930:
5925:
5920:
5915:
5905:
5900:
5895:
5890:
5885:
5880:
5875:
5865:
5860:
5855:
5815:
5768:
5763:
5758:
5753:
5748:
5743:
5733:
5721:
5716:
5482:
5477:
5472:
5354:
5349:
5321:
5316:
5301:
5296:
5291:
5281:
5276:
5264:
5259:
4631:
4626:
4621:
4616:
4611:
4586:
4513:
4481:
4424:
4419:
4206:
4201:
4196:
4080:
3885:
3775:
3770:
3743:
3738:
3733:
3659:
2445:
1510:
1506:
1502:
1434:
1239:
of the bHLH proteins is dependent on formation of homo- and/or hetero
1080:
832:
589:
DNA-binding transcription factor activity, RNA polymerase II-specific
2359:
2158:
Yun K, Mantani A, Garel S, Rubenstein J, Israel MA (November 2004).
3201:
2265:
1339:
ID4 is expressed in the central nervous system and is required for
8785:
8763:
8758:
8726:
8615:
8610:
8555:
8550:
8545:
8489:
8398:
8393:
8388:
8383:
8378:
8373:
8368:
8363:
8311:
8306:
8294:
8289:
8284:
8279:
8267:
8262:
8257:
8252:
8221:
8188:
8183:
8178:
8125:
8120:
8115:
8090:
8048:
8043:
8038:
8033:
8028:
8023:
7995:
7948:
7943:
7889:
7884:
7879:
7874:
7851:
7626:
7611:
7606:
7601:
7596:
7591:
7586:
7581:
7576:
7571:
7561:
7551:
7546:
7531:
7526:
7516:
7511:
7506:
7496:
7491:
7486:
7481:
7476:
7471:
7466:
7436:
7431:
7421:
7416:
7401:
7396:
7391:
7386:
7320:
7315:
7310:
7283:
7258:
7226:
7219:
7214:
7120:
7098:
7093:
7065:
7043:
7038:
7033:
7028:
6923:
6918:
6863:
6856:
6851:
6836:
6809:
6470:
6465:
6460:
6455:
6450:
6425:
6420:
6415:
6410:
6405:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6360:
6355:
6335:
6330:
6325:
6320:
6315:
6310:
6295:
6290:
6115:
6103:
6098:
6093:
6088:
6056:
6051:
5850:
5840:
5835:
5830:
5825:
5820:
5810:
5805:
5800:
5795:
5711:
5701:
5694:
5689:
5684:
5679:
5669:
5613:
5608:
5603:
5598:
5593:
5588:
5583:
5504:
5499:
5494:
5438:
5433:
5332:
5311:
5306:
5180:
5175:
5170:
5165:
5160:
5155:
4362:
4127:
4122:
4117:
4107:
4102:
4097:
4087:
4075:
4025:
4005:
3946:
3934:
3929:
3853:
3846:
3841:
3831:
3824:
3819:
3750:
3681:
3654:
3649:
3632:
3627:
3622:
3617:
3612:
3602:
3590:
3585:
3563:
3553:
3548:
3538:
1762:
Protein, Class B Basic Helix-Loop-Helix
Protein 27, and BHLHb272.
1466:
1430:
1402:
1394:
1178:
795:
791:
8812:
8807:
8802:
8792:
8780:
8775:
8622:
8605:
8469:
8464:
8459:
8430:
8425:
8358:
8353:
8348:
8343:
8338:
8333:
8328:
8323:
8274:
8168:
8130:
8105:
8100:
8095:
8078:
7970:
7963:
7958:
7839:
7834:
7829:
7824:
7819:
7814:
7809:
7804:
7794:
7787:
7777:
7772:
7760:
7750:
7745:
7728:
7723:
7718:
7701:
7696:
7691:
7666:
7661:
7656:
7374:
7369:
7364:
7359:
7354:
7293:
7268:
7263:
7204:
7199:
7194:
7189:
7184:
7179:
7174:
7169:
7164:
7135:
7130:
7023:
7018:
7013:
7008:
6994:
6989:
6984:
6979:
6974:
6945:
6940:
6935:
6901:
6896:
6891:
6886:
6881:
6876:
6841:
6829:
6824:
6819:
6772:
6767:
6762:
6757:
6752:
6673:
6658:
6648:
6624:
6619:
6605:
6600:
6595:
6585:
6580:
6568:
6563:
6507:
6502:
6280:
6265:
6260:
6248:
6243:
6076:
6071:
6066:
5910:
5845:
5790:
5785:
5780:
5664:
5659:
5654:
5578:
5573:
5568:
5563:
5558:
5553:
5548:
5543:
5538:
5521:
5516:
5460:
5455:
5423:
5418:
5413:
5403:
5398:
5391:
5386:
5381:
5376:
5366:
5361:
5344:
5202:
5197:
5192:
5120:
4581:
4576:
4571:
4566:
4561:
4556:
4469:
4454:
4431:
4404:
4377:
4372:
4337:
4315:
4310:
4305:
4288:
4283:
4273:
4263:
4213:
4171:
4166:
4149:
4144:
4139:
4037:
4032:
4020:
3978:
3973:
3963:
3878:
3873:
3863:
3782:
3765:
3728:
3716:
3711:
3686:
3644:
3573:
3568:
3543:
3526:
3521:
3516:
3511:
3506:
3496:
1925:"Atlas of Genetics and Cytogenetics in Oncology and Haematology"
1398:
1390:
1340:
1186:
1134:
86:
8583:
7912:
6154:
4654:
3456:
3414:
540:
8454:
8083:
8073:
7953:
7349:
6906:
6255:
5706:
5443:
4937:
4409:
4228:
4223:
4015:
4010:
3313:
Hagiwara K, Nagai H, Li Y, Ohashi H, Hotta T, Saito H (2007).
1359:
1177:
The gene spans 3.3kb on the plus strand. It is composed of 3
2297:
Ren Y, Cheung HW, von
Maltzhan G, et al. (August 2012).
30:
For the film which uses "ID4" as a marketing initialism, see
3017:
Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002).
1694:
is hypermethylated and infrequently expressed in gastric
1484:. The ID4 gene is also seen to be overexpressed in most
756:
positive regulation of transcription by RNA polymerase II
671:
negative regulation of transcription by RNA polymerase II
2199:
Cunningham TJ, Yu MS, McKeithan WL, et al. (2017).
342:
73:, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
1636:
is responsible for regulation of ID4 expression in the
1381:
ID4 was also shown to be involved in the regulation of
706:
negative regulation of oligodendrocyte differentiation
2021:
Pagliuca A, Cannada-Bartoli P, Lania L (March 1998).
1577:, the ID4 gene has been shown to be expressed in the
1437:
which are known to be associated with endometriosis.
507:
3319:
Journal of
Clinical and Experimental Hematopathology
2153:
2151:
716:
positive regulation of cell population proliferation
8702:
8662:
8631:
8596:
8521:
8498:
8480:
8230:
8204:
8156:
8059:
8006:
7926:
7860:
7677:
7637:
7333:
7150:
6790:
6516:
6204:
6185:
6173:
6124:
6037:
6016:
5218:
5138:
5109:
5089:
5064:
5027:
4946:
4842:
4690:
4671:
4597:
4542:
4440:
4350:
4326:
4249:
4182:
4046:
3996:
3805:
3791:
3469:
1643:It is unclear whether the ID4 gene plays a role in
1041:
1020:
994:
973:
741:
negative regulation of transcription, DNA-templated
3225:Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA (2006).
2661:Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA (2005).
2201:"Id genes are essential for early heart formation"
1812:
1810:
1808:
1791:
1789:
1787:
1616:. ID4 is constitutively expressed in normal human
1938:Riechmann V, van Crüchten I, Sablitzky F (1994).
1604:have shown ID4 expression in their breast cancer
1473:. It has been shown to be overexpressed in most
1354:. It is complexly involved in regulating neural
1189:is 2343 bp. The encoded protein consists of 161
696:positive regulation of osteoblast differentiation
289:
188:
1336:in the developing stomach during embryogenesis.
666:regulation of transcription by RNA polymerase II
646:negative regulation of astrocyte differentiation
641:negative regulation of fat cell differentiation
1817:GRCm38: Ensembl release 89: ENSMUSG00000021379
8845:transcription factor/coregulator deficiencies
7916:β-Scaffold factors with minor groove contacts
3426:
2794:Peddada S, Yasui DH, LaSalle JM (June 2006).
1608:. This has been identified as a significant
656:negative regulation of neuron differentiation
8:
2114:Jen Y, Manova K, Benezra R (November 1996).
3109:Shan L, Yu M, Qiu C, Snyderwine EG (2004).
1796:GRCh38: Ensembl release 89: ENSG00000172201
1709:ID4 is not found in normal epitheliums nor
8858:United States National Library of Medicine
8593:
8580:
7923:
7909:
6201:
6182:
6170:
6151:
4687:
4668:
4651:
3802:
3466:
3453:
3433:
3419:
3411:
2615:
2613:
2060:
2058:
1313:. Later stages show ID4 expression in the
806:
651:regulation of transcription, DNA-templated
556:
330:
229:
126:
3403:at the U.S. National Library of Medicine
3375:
3365:
3330:
3295:
3252:
3242:
3169:
3134:
3091:
3034:
2999:
2989:
2946:
2873:
2819:
2770:
2729:
2688:
2678:
2637:
2593:
2552:
2542:
2493:
2444:
2434:
2322:
2273:
2224:
2175:
2131:
2082:
2065:Kee Y, Bronner-Fraser M (December 2001).
2038:
1963:
1681:, but also seen in fresh cancer tissues.
1620:epithelium but found to be suppressed in
1214:that work by negatively regulating their
594:DNA-binding transcription factor activity
8856:This article incorporates text from the
3270:Peddada S, Yasui DH, LaSalle JM (2006).
1919:
1917:
1902:
1900:
1283:and restricted to specific cells of the
2848:Loveys DA, Streiff MB, Kato GJ (1996).
1783:
701:prostate gland epithelium morphogenesis
1987:Riechmann V, Sablitzky F (July 1995).
1324:. ID4 expression is only detected in
731:cerebral cortex neuron differentiation
691:positive regulation of gene expression
43:
761:G1/S transition of mitotic cell cycle
294:
255:
250:
193:
152:
147:
7:
1653:which is frequently associated with
1624:breast carcinomas and preneoplastic
636:prostate gland stromal morphogenesis
37:. For the battery electric car, see
4599:(1.6) Basic helix-span-helix (bHSH)
1038:
1017:
991:
970:
946:
927:
901:
882:
856:
837:
771:negative regulation of DNA binding
661:central nervous system myelination
579:transcription corepressor activity
512:
430:
368:
347:
25:
1993:Cell Growth & Differentiation
1772:Inhibitor of DNA-binding protein
1378:much later than other ID genes.
530:
523:
516:
278:
271:
265:
242:
177:
170:
164:
139:
8586:(0) Other transcription factors
7870:transcriptional enhancer factor
3487:Activating transcription factor
2027:Journal of Biological Chemistry
1684:ID4 is closely associated with
1465:ID4 is not expressed in normal
1263:Regulation during embryogenesis
2303:Science Translational Medicine
1649:. ID4 is found on the 6p22.3
1447:single nucleotide polymorphism
1397:) whilst activating inducers (
541:More reference expression data
496:More reference expression data
1:
7800:Interferon regulatory factors
6039:(2.5) Alternating composition
5235:General transcription factors
3171:10.1158/1078-0432.CCR-04-0689
3127:10.1016/S0002-9440(10)63604-8
2639:10.1158/1541-7786.MCR-05-0199
2084:10.1016/S0925-4773(01)00576-7
1524:acute lymphoblastic leukaemia
1442:genome wide association study
736:cell population proliferation
681:seminal vesicle morphogenesis
574:protein dimerization activity
263:
162:
27:Protein-coding gene in humans
7085:Octamer transcription factor
3793:(1.2) Basic helix-loop-helix
2970:Proc. Natl. Acad. Sci. U.S.A
2582:Journal of Clinical Oncology
2436:10.1182/blood-2007-07-092015
2315:10.1126/scitranslmed.3003778
721:prostate gland morphogenesis
676:transcription, DNA-templated
599:transcription factor binding
8878:Genes on human chromosome 6
3859:Myogenic regulatory factors
1418:ID4 has been linked to the
8899:
2495:10.1016/j.stem.2007.10.020
1343:transition and to enhance
1212:transcriptional regulators
781:osteoblast differentiation
420:left lobe of thyroid gland
29:
8840:
8592:
8579:
7922:
7908:
7679:(3.5) Tryptophan clusters
6169:
6150:
4667:
4650:
3465:
3452:
2626:Molecular Cancer Research
2071:Mechanisms of Development
1999:: 837–843. Archived from
1852:"Mouse PubMed Reference:"
1834:"Human PubMed Reference:"
1584:but not expressed in the
1461:Tumorigenesis association
1289:peripheral nervous system
1147:embryonic cellular growth
1111:
1106:
1102:
1095:
1079:
1060:
1045:
1024:
1013:
998:
977:
966:
953:
949:
934:
930:
921:
908:
904:
889:
885:
876:
863:
859:
844:
840:
831:
816:
809:
805:
789:
559:
555:
538:
515:
506:
493:
442:
433:
380:
371:
341:
333:
329:
312:
299:
262:
241:
232:
228:
211:
198:
161:
138:
129:
125:
80:
77:
67:
60:
55:
51:
46:
8500:(4.10) Cold-shock domain
3405:Medical Subject Headings
2800:Human Molecular Genetics
2595:10.1200/JCO.2006.05.9493
2348:Nature Reviews. Genetics
1249:DNA-binding basic domain
1155:cellular differentiation
1145:. This is inclusive of
1073:Chr 13: 48.41 – 48.42 Mb
776:regulation of cell cycle
751:fat cell differentiation
726:neuroblast proliferation
450:Rostral migratory stream
3446:intracellular receptors
3367:10.1186/1471-2407-8-154
2544:10.1073/pnas.0402870102
2205:Genes & Development
2040:10.1074/jbc.273.13.7668
1731:Developmental disorders
1066:Chr 6: 19.84 – 19.84 Mb
746:hippocampus development
3244:10.1186/1476-4598-4-16
3093:10.1038/sj.onc.1206799
3036:10.1074/jbc.M107713200
2948:10.1093/dnares/5.5.309
2866:10.1093/nar/24.14.2813
2772:10.1038/sj.onc.1208538
2731:10.1038/sj.onc.1206799
2680:10.1186/1476-4598-4-16
2217:10.1101/gad.300400.117
2120:Developmental Dynamics
1944:Nucleic Acids Research
1883:10.1006/geno.1995.1026
1453:rs7739264 near ID4 on
1305:, the segmental plate
1216:basic helix-loop-helix
766:neuron differentiation
462:lateral septal nucleus
296:13 A5|13 24.71 cM
8883:Transcription factors
8209:TATA-binding proteins
3442:Transcription factors
2991:10.1073/pnas.98.1.130
1414:Role in endometriosis
1409:Clinical significance
1220:transcription factors
458:medial dorsal nucleus
257:Chromosome 13 (mouse)
1956:10.1093/nar/22.5.749
1569:, more specifically
1546:follicular lymphomas
1537:Non Hodgkin lymphoma
1259:with bHLH proteins.
1237:DNA-binding activity
1139:prenatal development
155:Chromosome 6 (human)
8704:(0.6) Miscellaneous
8235:High-mobility group
7931:Rel homology region
4921:Testicular receptor
4662:DNA-binding domains
3332:10.3960/jslrt.47.15
2982:2001PNAS...98..130B
2535:2005PNAS..102.5814L
1757:Commonly used names
1752:Society and culture
396:germinal epithelium
8860:, which is in the
8069:p53 p63 p73 family
7642:Heat shock factors
3401:ID4+protein,+human
3288:10.1093/hmg/ddl124
2812:10.1093/hmg/ddl124
1556:cell lines due to
1322:corneal epithelium
1296:neural crest cells
1277:foetal development
1257:heterodimerization
911:ENSMUSG00000021379
629:Biological process
608:Cellular component
567:Molecular function
466:supraoptic nucleus
446:olfactory tubercle
8852:
8851:
8836:
8835:
8832:
8831:
8575:
8574:
8571:
8570:
7904:
7903:
7900:
7899:
7146:
7145:
6786:
6785:
6146:
6145:
6142:
6141:
5134:
5133:
4990:Mineralocorticoid
4646:
4645:
4642:
4641:
4346:
4345:
3459:(1) Basic domains
2854:Nucleic Acids Res
2806:(12): 2003–2014.
2765:(29): 4721–4727.
2724:(44): 6946–6953.
2588:(26): 4270–4276.
2529:(16): 5814–5819.
2309:(147): 147ra112.
2211:(13): 1325–1338.
2177:10.1242/dev.01430
2170:(21): 5441–5448.
2033:(13): 7668–7674.
1716:colorectal cancer
1677:and parts of the
1665:inclusive of the
1544:is implicated in
1531:enhancer region.
1245:Dominant-negative
1122:
1121:
1118:
1117:
1091:
1090:
1056:
1055:
1035:
1034:
1009:
1008:
988:
987:
962:
961:
943:
942:
917:
916:
898:
897:
872:
871:
853:
852:
801:
800:
686:brain development
551:
550:
547:
546:
502:
501:
489:
488:
470:nucleus accumbens
427:
426:
325:
324:
224:
223:
16:(Redirected from
8890:
8676:-related factors
8594:
8581:
8482:(4.9) Grainyhead
7924:
7910:
7862:(3.6) TEA domain
7152:(3.2) Paired box
6793:
6527:
6521:
6215:
6209:
6202:
6198:
6192:
6183:
6171:
6160:Helix-turn-helix
6152:
5114:
5094:
5069:
5032:
5002:Estrogen related
4951:
4847:
4695:
4688:
4676:Nuclear receptor
4669:
4652:
4331:
4252:
4185:
4054:
3999:
3808:
3803:
3467:
3454:
3435:
3428:
3421:
3412:
3389:
3379:
3369:
3344:
3334:
3309:
3299:
3266:
3256:
3246:
3221:
3183:
3173:
3158:Clin. Cancer Res
3148:
3138:
3105:
3095:
3070:
3048:
3038:
3013:
3003:
2993:
2960:
2950:
2925:
2894:J. Neurosci. Res
2887:
2877:
2834:
2833:
2823:
2791:
2785:
2784:
2774:
2750:
2744:
2743:
2733:
2709:
2703:
2702:
2692:
2682:
2667:Molecular Cancer
2658:
2652:
2651:
2641:
2617:
2608:
2607:
2597:
2573:
2567:
2566:
2556:
2546:
2514:
2508:
2507:
2497:
2473:
2467:
2466:
2448:
2438:
2414:
2408:
2407:
2386:
2380:
2379:
2343:
2337:
2336:
2326:
2294:
2288:
2287:
2277:
2245:
2239:
2238:
2228:
2196:
2190:
2189:
2179:
2155:
2146:
2145:
2135:
2111:
2105:
2104:
2086:
2062:
2053:
2052:
2042:
2018:
2012:
2011:
2009:
2008:
1984:
1978:
1977:
1967:
1935:
1929:
1928:
1921:
1912:
1911:
1904:
1895:
1894:
1866:
1860:
1859:
1848:
1842:
1841:
1830:
1824:
1814:
1803:
1793:
1745:neurodevelopment
1661:which lines the
1589:oligodendrocytes
1571:oligodendroglial
1558:hypermethylation
1550:B Cell lymphomas
1328:tissues and the
1195:helix-loop-helix
1104:
1103:
1075:
1068:
1051:
1039:
1030:
1018:
1014:RefSeq (protein)
1004:
992:
983:
971:
947:
928:
902:
883:
857:
838:
807:
711:circadian rhythm
557:
543:
534:
527:
520:
513:
498:
438:
436:Top expressed in
431:
416:seminal vesicula
392:ventricular zone
376:
374:Top expressed in
369:
348:
331:
321:
308:
297:
282:
275:
269:
258:
246:
230:
220:
207:
196:
181:
174:
168:
157:
143:
127:
121:
72:
65:
44:
33:Independence Day
21:
8898:
8897:
8893:
8892:
8891:
8889:
8888:
8887:
8868:
8867:
8853:
8848:
8828:
8698:
8658:
8627:
8588:
8567:
8517:
8494:
8476:
8226:
8200:
8152:
8055:
8002:
7918:
7896:
7856:
7673:
7633:
7329:
7142:
6791:
6782:
6523:
6522:
6517:
6512:
6211:
6210:
6205:
6194:
6193:
6186:
6165:
6138:
6120:
6033:
6021:
6012:
5227:
5223:
5214:
5143:
5140:(2.2) Other Cys
5130:
5110:
5105:
5090:
5085:
5065:
5060:
5028:
5023:
4958:Steroid hormone
4947:
4942:
4843:
4838:
4702:Thyroid hormone
4691:
4682:
4663:
4638:
4593:
4538:
4436:
4342:
4329:
4327:
4322:
4250:
4245:
4183:
4178:
4049:
4047:
4042:
3997:
3992:
3806:
3787:
3461:
3448:
3439:
3397:
3392:
3347:
3312:
3282:(12): 2003–14.
3276:Hum. Mol. Genet
3269:
3224:
3186:
3164:(22): 7475–83.
3151:
3121:(6): 2495–502.
3108:
3086:(44): 6946–53.
3073:
3061:(9): 994–1001.
3051:
3029:(11): 9118–26.
3016:
2963:
2928:
2890:
2860:(14): 2813–20.
2847:
2843:
2841:Further reading
2838:
2837:
2793:
2792:
2788:
2752:
2751:
2747:
2711:
2710:
2706:
2660:
2659:
2655:
2619:
2618:
2611:
2575:
2574:
2570:
2516:
2515:
2511:
2475:
2474:
2470:
2416:
2415:
2411:
2398:(9): 994–1001.
2388:
2387:
2383:
2360:10.1038/nrg1225
2354:(12): 969–980.
2345:
2344:
2340:
2296:
2295:
2291:
2254:Nature Genetics
2247:
2246:
2242:
2198:
2197:
2193:
2157:
2156:
2149:
2113:
2112:
2108:
2064:
2063:
2056:
2020:
2019:
2015:
2006:
2004:
1986:
1985:
1981:
1937:
1936:
1932:
1923:
1922:
1915:
1906:
1905:
1898:
1868:
1867:
1863:
1850:
1849:
1845:
1832:
1831:
1827:
1815:
1806:
1794:
1785:
1780:
1768:
1759:
1754:
1733:
1696:adenocarcinomas
1692:promoter region
1542:promoter region
1481:ovarian cancers
1471:fallopian tubes
1463:
1416:
1411:
1332:portion of the
1265:
1253:transactivation
1203:
1175:
1113:View/Edit Mouse
1108:View/Edit Human
1071:
1064:
1061:Location (UCSC)
1047:
1026:
1000:
979:
892:ENSG00000172201
785:
624:
603:
584:protein binding
539:
529:
528:
522:
521:
494:
485:
480:
478:globus pallidus
476:
472:
468:
464:
460:
456:
452:
448:
434:
423:
418:
414:
410:
406:
402:
398:
394:
390:
386:
372:
316:
303:
295:
285:
284:
283:
276:
256:
233:Gene location (
215:
202:
194:
184:
183:
182:
175:
153:
130:Gene location (
119:ID4 - orthologs
81:
68:
61:
42:
39:Volkswagen ID.4
28:
23:
22:
15:
12:
11:
5:
8896:
8894:
8886:
8885:
8880:
8870:
8869:
8850:
8849:
8841:
8838:
8837:
8834:
8833:
8830:
8829:
8827:
8826:
8817:
8816:
8815:
8810:
8805:
8795:
8790:
8789:
8788:
8783:
8778:
8768:
8767:
8766:
8761:
8751:
8746:
8745:
8744:
8739:
8734:
8729:
8724:
8719:
8708:
8706:
8700:
8699:
8697:
8696:
8691:
8686:
8680:
8678:
8660:
8659:
8657:
8656:
8651:
8646:
8640:
8638:
8629:
8628:
8626:
8625:
8620:
8619:
8618:
8613:
8602:
8600:
8590:
8589:
8584:
8577:
8576:
8573:
8572:
8569:
8568:
8566:
8565:
8564:
8563:
8558:
8553:
8548:
8543:
8538:
8527:
8525:
8519:
8518:
8516:
8515:
8510:
8504:
8502:
8496:
8495:
8493:
8492:
8486:
8484:
8478:
8477:
8475:
8474:
8473:
8472:
8467:
8462:
8457:
8447:
8446:
8445:
8440:
8439:
8438:
8433:
8428:
8413:
8408:
8403:
8402:
8401:
8396:
8391:
8386:
8381:
8376:
8371:
8366:
8361:
8356:
8351:
8346:
8341:
8336:
8331:
8326:
8316:
8315:
8314:
8309:
8299:
8298:
8297:
8292:
8287:
8282:
8272:
8271:
8270:
8265:
8260:
8255:
8245:
8239:
8237:
8228:
8227:
8225:
8224:
8219:
8213:
8211:
8202:
8201:
8199:
8198:
8193:
8192:
8191:
8186:
8181:
8176:
8165:
8163:
8154:
8153:
8151:
8150:
8145:
8144:
8143:
8138:
8133:
8128:
8123:
8118:
8113:
8108:
8103:
8098:
8088:
8087:
8086:
8081:
8076:
8065:
8063:
8061:(4.3) p53-like
8057:
8056:
8054:
8053:
8052:
8051:
8046:
8041:
8036:
8031:
8026:
8015:
8013:
8004:
8003:
8001:
8000:
7999:
7998:
7993:
7988:
7983:
7978:
7968:
7967:
7966:
7961:
7956:
7951:
7946:
7935:
7933:
7920:
7919:
7913:
7906:
7905:
7902:
7901:
7898:
7897:
7895:
7894:
7893:
7892:
7887:
7882:
7877:
7866:
7864:
7858:
7857:
7855:
7854:
7849:
7844:
7843:
7842:
7837:
7832:
7827:
7822:
7817:
7812:
7807:
7797:
7792:
7791:
7790:
7785:
7780:
7775:
7765:
7764:
7763:
7758:
7753:
7748:
7738:
7733:
7732:
7731:
7726:
7721:
7711:
7706:
7705:
7704:
7699:
7694:
7683:
7681:
7675:
7674:
7672:
7671:
7670:
7669:
7664:
7659:
7646:
7644:
7635:
7634:
7632:
7631:
7630:
7629:
7624:
7619:
7614:
7609:
7604:
7599:
7594:
7589:
7584:
7579:
7574:
7569:
7564:
7559:
7554:
7549:
7544:
7539:
7534:
7529:
7524:
7519:
7514:
7509:
7504:
7499:
7494:
7489:
7484:
7479:
7474:
7469:
7464:
7459:
7454:
7449:
7444:
7439:
7434:
7429:
7424:
7419:
7414:
7409:
7404:
7399:
7394:
7389:
7379:
7378:
7377:
7372:
7367:
7362:
7357:
7346:
7344:
7331:
7330:
7328:
7327:
7326:
7325:
7324:
7323:
7318:
7313:
7303:
7302:
7301:
7296:
7286:
7281:
7271:
7266:
7261:
7256:
7251:
7246:
7245:
7244:
7239:
7229:
7224:
7223:
7222:
7217:
7209:
7208:
7207:
7202:
7197:
7192:
7187:
7182:
7177:
7172:
7167:
7156:
7154:
7148:
7147:
7144:
7143:
7141:
7140:
7139:
7138:
7133:
7123:
7118:
7117:
7116:
7111:
7106:
7101:
7096:
7091:
7082:
7077:
7072:
7063:
7053:
7052:
7051:
7046:
7041:
7036:
7031:
7026:
7021:
7016:
7011:
7001:
7000:
6999:
6998:
6997:
6992:
6987:
6982:
6977:
6967:
6966:
6965:
6960:
6950:
6949:
6948:
6943:
6938:
6928:
6927:
6926:
6921:
6911:
6910:
6909:
6904:
6899:
6894:
6889:
6884:
6879:
6866:
6861:
6860:
6859:
6854:
6844:
6839:
6834:
6833:
6832:
6827:
6822:
6812:
6807:
6802:
6796:
6794:
6788:
6787:
6784:
6783:
6781:
6780:
6775:
6770:
6765:
6760:
6755:
6750:
6749:
6748:
6743:
6738:
6733:
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6688:
6683:
6682:
6681:
6676:
6666:
6661:
6656:
6651:
6646:
6645:
6644:
6639:
6629:
6628:
6627:
6622:
6610:
6609:
6608:
6603:
6598:
6593:
6588:
6583:
6573:
6572:
6571:
6566:
6556:
6551:
6546:
6541:
6536:
6530:
6528:
6514:
6513:
6511:
6510:
6505:
6500:
6495:
6494:
6493:
6488:
6483:
6478:
6473:
6468:
6463:
6458:
6453:
6448:
6443:
6438:
6433:
6428:
6423:
6418:
6413:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6373:
6368:
6363:
6358:
6353:
6348:
6343:
6338:
6333:
6328:
6323:
6318:
6313:
6308:
6298:
6293:
6288:
6283:
6279:extended Hox:
6277:
6276:
6275:
6274:
6273:
6268:
6263:
6253:
6252:
6251:
6241:
6240:
6239:
6234:
6218:
6216:
6199:
6180:
6167:
6166:
6155:
6148:
6147:
6144:
6143:
6140:
6139:
6137:
6136:
6130:
6128:
6122:
6121:
6119:
6118:
6113:
6112:
6111:
6106:
6101:
6096:
6091:
6081:
6080:
6079:
6074:
6069:
6059:
6054:
6049:
6043:
6041:
6035:
6034:
6032:
6031:
6025:
6023:
6019:
6014:
6013:
6011:
6010:
6009:
6008:
6003:
5998:
5993:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5918:
5913:
5908:
5903:
5898:
5893:
5888:
5883:
5878:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5833:
5828:
5823:
5818:
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5773:
5772:
5771:
5766:
5761:
5756:
5751:
5746:
5741:
5736:
5726:
5725:
5724:
5719:
5709:
5704:
5699:
5698:
5697:
5692:
5687:
5682:
5672:
5667:
5662:
5657:
5652:
5651:
5650:
5649:
5648:
5643:
5638:
5633:
5628:
5618:
5617:
5616:
5611:
5606:
5601:
5596:
5591:
5586:
5581:
5576:
5571:
5566:
5561:
5556:
5551:
5546:
5541:
5526:
5525:
5524:
5519:
5509:
5508:
5507:
5502:
5497:
5487:
5486:
5485:
5480:
5475:
5465:
5464:
5463:
5458:
5448:
5447:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5406:
5401:
5396:
5395:
5394:
5389:
5384:
5379:
5369:
5364:
5359:
5358:
5357:
5352:
5347:
5335:
5329:
5328:
5327:
5326:
5325:
5324:
5319:
5314:
5309:
5304:
5299:
5294:
5289:
5279:
5274:
5269:
5268:
5267:
5262:
5252:
5247:
5242:
5231:
5229:
5225:
5221:
5216:
5215:
5213:
5212:
5207:
5206:
5205:
5200:
5195:
5185:
5184:
5183:
5178:
5173:
5168:
5163:
5158:
5147:
5145:
5141:
5136:
5135:
5132:
5131:
5129:
5128:
5123:
5117:
5115:
5107:
5106:
5104:
5103:
5097:
5095:
5087:
5086:
5084:
5083:
5078:
5072:
5070:
5062:
5061:
5059:
5058:
5057:
5056:
5051:
5046:
5035:
5033:
5025:
5024:
5022:
5021:
5020:
5019:
5014:
5009:
4999:
4998:
4997:
4992:
4987:
4985:Glucocorticoid
4982:
4981:
4980:
4975:
4965:
4954:
4952:
4944:
4943:
4941:
4940:
4935:
4934:
4933:
4928:
4918:
4917:
4916:
4911:
4906:
4896:
4891:
4890:
4889:
4884:
4874:
4869:
4868:
4867:
4862:
4850:
4848:
4840:
4839:
4837:
4836:
4831:
4830:
4829:
4824:
4814:
4813:
4812:
4807:
4802:
4792:
4791:
4790:
4785:
4780:
4770:
4765:
4764:
4763:
4758:
4753:
4743:
4742:
4741:
4736:
4726:
4721:
4716:
4715:
4714:
4709:
4698:
4696:
4685:
4680:
4665:
4664:
4655:
4648:
4647:
4644:
4643:
4640:
4639:
4637:
4636:
4635:
4634:
4629:
4624:
4619:
4614:
4603:
4601:
4595:
4594:
4592:
4591:
4590:
4589:
4584:
4579:
4574:
4569:
4564:
4559:
4548:
4546:
4540:
4539:
4537:
4536:
4535:
4534:
4528:
4527:
4526:
4521:
4511:
4510:
4509:
4504:
4499:
4494:
4489:
4474:
4473:
4472:
4467:
4462:
4457:
4446:
4444:
4438:
4437:
4435:
4434:
4429:
4428:
4427:
4422:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4381:
4380:
4375:
4365:
4359:
4357:
4348:
4347:
4344:
4343:
4341:
4340:
4334:
4332:
4324:
4323:
4321:
4320:
4319:
4318:
4313:
4308:
4298:
4297:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4255:
4253:
4247:
4246:
4244:
4243:
4242:
4241:
4236:
4231:
4226:
4216:
4211:
4210:
4209:
4204:
4199:
4188:
4186:
4180:
4179:
4177:
4176:
4175:
4174:
4169:
4159:
4158:
4157:
4152:
4147:
4142:
4132:
4131:
4130:
4125:
4120:
4112:
4111:
4110:
4105:
4100:
4090:
4085:
4084:
4083:
4078:
4068:
4063:
4057:
4055:
4044:
4043:
4041:
4040:
4035:
4030:
4029:
4028:
4023:
4018:
4008:
4002:
4000:
3994:
3993:
3991:
3990:
3985:
3984:
3983:
3982:
3981:
3976:
3966:
3956:
3955:
3954:
3949:
3939:
3938:
3937:
3932:
3922:
3921:
3920:
3915:
3910:
3900:
3899:
3898:
3893:
3883:
3882:
3881:
3876:
3871:
3866:
3856:
3851:
3850:
3849:
3844:
3834:
3829:
3828:
3827:
3822:
3811:
3809:
3800:
3789:
3788:
3786:
3785:
3780:
3779:
3778:
3773:
3768:
3758:
3753:
3748:
3747:
3746:
3741:
3736:
3731:
3721:
3720:
3719:
3714:
3709:
3704:
3694:
3689:
3684:
3679:
3674:
3669:
3664:
3663:
3662:
3657:
3652:
3642:
3641:
3640:
3635:
3630:
3625:
3620:
3615:
3605:
3600:
3595:
3594:
3593:
3588:
3578:
3577:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3531:
3530:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3483:
3481:
3474:leucine zipper
3463:
3462:
3457:
3450:
3449:
3440:
3438:
3437:
3430:
3423:
3415:
3409:
3408:
3396:
3395:External links
3393:
3391:
3390:
3345:
3310:
3267:
3222:
3202:10.1038/ng1521
3184:
3149:
3106:
3071:
3049:
3014:
2961:
2926:
2900:(5): 684–701.
2888:
2844:
2842:
2839:
2836:
2835:
2786:
2745:
2704:
2653:
2632:(5): 303–309.
2609:
2568:
2509:
2488:(6): 685–697.
2482:Cell Stem Cell
2468:
2429:(1): 387–391.
2409:
2381:
2338:
2289:
2266:10.1038/ng.731
2240:
2191:
2147:
2126:(3): 235–252.
2106:
2077:(2): 341–345.
2054:
2013:
1979:
1950:(5): 749–755.
1930:
1913:
1896:
1861:
1843:
1825:
1804:
1782:
1781:
1779:
1776:
1775:
1774:
1767:
1764:
1758:
1755:
1753:
1750:
1732:
1729:
1704:microsatellite
1700:gastric mucosa
1687:gastric cancer
1646:bladder cancer
1638:mammary ductal
1462:
1459:
1415:
1412:
1410:
1407:
1264:
1261:
1202:
1199:
1174:
1171:
1120:
1119:
1116:
1115:
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1100:
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1021:
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944:
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931:
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802:
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753:
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733:
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723:
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703:
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693:
688:
683:
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623:
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581:
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510:
504:
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335:RNA expression
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8862:public domain
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8636:Pocket domain
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8599:
8598:(0.2) HMGI(Y)
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5529:Sp/KLF family
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4841:
4835:
4832:
4828:
4825:
4823:
4820:
4819:
4818:
4815:
4811:
4808:
4806:
4803:
4801:
4798:
4797:
4796:
4793:
4789:
4786:
4784:
4781:
4779:
4776:
4775:
4774:
4771:
4769:
4766:
4762:
4759:
4757:
4754:
4752:
4749:
4748:
4747:
4744:
4740:
4737:
4735:
4732:
4731:
4730:
4727:
4725:
4722:
4720:
4717:
4713:
4710:
4708:
4705:
4704:
4703:
4700:
4699:
4697:
4694:
4689:
4686:
4684:
4677:
4674:
4670:
4666:
4661:
4658:
4653:
4649:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4609:
4608:
4605:
4604:
4602:
4600:
4596:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4554:
4553:
4550:
4549:
4547:
4545:
4541:
4532:
4529:
4525:
4522:
4520:
4517:
4516:
4515:
4512:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4484:
4483:
4480:
4479:
4478:
4475:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4452:
4451:
4448:
4447:
4445:
4443:
4439:
4433:
4430:
4426:
4423:
4421:
4418:
4417:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4379:
4376:
4374:
4371:
4370:
4369:
4366:
4364:
4361:
4360:
4358:
4356:
4353:
4349:
4339:
4336:
4335:
4333:
4325:
4317:
4314:
4312:
4309:
4307:
4304:
4303:
4302:
4299:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4261:
4260:
4257:
4256:
4254:
4248:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4221:
4220:
4217:
4215:
4212:
4208:
4205:
4203:
4200:
4198:
4195:
4194:
4193:
4190:
4189:
4187:
4181:
4173:
4170:
4168:
4165:
4164:
4163:
4160:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4137:
4136:
4133:
4129:
4126:
4124:
4121:
4119:
4116:
4115:
4113:
4109:
4106:
4104:
4101:
4099:
4096:
4095:
4094:
4091:
4089:
4086:
4082:
4079:
4077:
4074:
4073:
4072:
4069:
4067:
4064:
4062:
4059:
4058:
4056:
4053:
4045:
4039:
4036:
4034:
4031:
4027:
4024:
4022:
4019:
4017:
4014:
4013:
4012:
4009:
4007:
4004:
4003:
4001:
3995:
3989:
3986:
3980:
3977:
3975:
3972:
3971:
3970:
3967:
3965:
3962:
3961:
3960:
3957:
3953:
3950:
3948:
3945:
3944:
3943:
3940:
3936:
3933:
3931:
3928:
3927:
3926:
3923:
3919:
3916:
3914:
3911:
3909:
3906:
3905:
3904:
3901:
3897:
3894:
3892:
3889:
3888:
3887:
3884:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3861:
3860:
3857:
3855:
3852:
3848:
3845:
3843:
3840:
3839:
3838:
3835:
3833:
3830:
3826:
3823:
3821:
3818:
3817:
3816:
3813:
3812:
3810:
3804:
3801:
3798:
3794:
3790:
3784:
3781:
3777:
3774:
3772:
3769:
3767:
3764:
3763:
3762:
3759:
3757:
3754:
3752:
3749:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3726:
3725:
3722:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3699:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3661:
3658:
3656:
3653:
3651:
3648:
3647:
3646:
3643:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3610:
3609:
3606:
3604:
3601:
3599:
3596:
3592:
3589:
3587:
3584:
3583:
3582:
3579:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3536:
3535:
3532:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3489:
3488:
3485:
3484:
3482:
3479:
3475:
3472:
3468:
3464:
3460:
3455:
3451:
3447:
3443:
3436:
3431:
3429:
3424:
3422:
3417:
3416:
3413:
3406:
3402:
3399:
3398:
3394:
3387:
3383:
3378:
3373:
3368:
3363:
3359:
3355:
3351:
3346:
3342:
3338:
3333:
3328:
3324:
3320:
3316:
3311:
3307:
3303:
3298:
3293:
3289:
3285:
3281:
3277:
3273:
3268:
3264:
3260:
3255:
3250:
3245:
3240:
3236:
3232:
3228:
3223:
3219:
3215:
3211:
3207:
3203:
3199:
3196:(3): 265–74.
3195:
3191:
3185:
3181:
3177:
3172:
3167:
3163:
3159:
3155:
3150:
3146:
3142:
3137:
3132:
3128:
3124:
3120:
3116:
3115:Am. J. Pathol
3112:
3107:
3103:
3099:
3094:
3089:
3085:
3081:
3077:
3072:
3068:
3064:
3060:
3056:
3055:Haematologica
3050:
3046:
3042:
3037:
3032:
3028:
3024:
3023:J. Biol. Chem
3020:
3015:
3011:
3007:
3002:
2997:
2992:
2987:
2983:
2979:
2975:
2971:
2967:
2962:
2958:
2954:
2949:
2944:
2941:(5): 309–13.
2940:
2936:
2932:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2889:
2885:
2881:
2876:
2871:
2867:
2863:
2859:
2855:
2851:
2846:
2845:
2840:
2831:
2827:
2822:
2817:
2813:
2809:
2805:
2801:
2797:
2790:
2787:
2782:
2778:
2773:
2768:
2764:
2760:
2756:
2749:
2746:
2741:
2737:
2732:
2727:
2723:
2719:
2715:
2708:
2705:
2700:
2696:
2691:
2686:
2681:
2676:
2672:
2668:
2664:
2657:
2654:
2649:
2645:
2640:
2635:
2631:
2627:
2623:
2616:
2614:
2610:
2605:
2601:
2596:
2591:
2587:
2583:
2579:
2572:
2569:
2564:
2560:
2555:
2550:
2545:
2540:
2536:
2532:
2528:
2524:
2520:
2513:
2510:
2505:
2501:
2496:
2491:
2487:
2483:
2479:
2472:
2469:
2464:
2460:
2456:
2452:
2447:
2442:
2437:
2432:
2428:
2424:
2420:
2413:
2410:
2405:
2401:
2397:
2393:
2392:Haematologica
2385:
2382:
2377:
2373:
2369:
2365:
2361:
2357:
2353:
2349:
2342:
2339:
2334:
2330:
2325:
2320:
2316:
2312:
2308:
2304:
2300:
2293:
2290:
2285:
2281:
2276:
2271:
2267:
2263:
2259:
2255:
2251:
2244:
2241:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2206:
2202:
2195:
2192:
2187:
2183:
2178:
2173:
2169:
2165:
2161:
2154:
2152:
2148:
2143:
2139:
2134:
2129:
2125:
2121:
2117:
2110:
2107:
2102:
2098:
2094:
2090:
2085:
2080:
2076:
2072:
2068:
2061:
2059:
2055:
2050:
2046:
2041:
2036:
2032:
2028:
2024:
2017:
2014:
2003:on 2020-08-14
2002:
1998:
1994:
1990:
1983:
1980:
1975:
1971:
1966:
1961:
1957:
1953:
1949:
1945:
1941:
1934:
1931:
1926:
1920:
1918:
1914:
1909:
1903:
1901:
1897:
1892:
1888:
1884:
1880:
1876:
1872:
1865:
1862:
1857:
1853:
1847:
1844:
1839:
1835:
1829:
1826:
1822:
1818:
1813:
1811:
1809:
1805:
1801:
1797:
1792:
1790:
1788:
1784:
1777:
1773:
1770:
1769:
1765:
1763:
1756:
1751:
1749:
1746:
1743:
1739:
1738:
1737:Rett syndrome
1730:
1728:
1726:
1722:
1718:
1717:
1712:
1707:
1706:instability.
1705:
1701:
1697:
1693:
1689:
1688:
1682:
1680:
1676:
1672:
1668:
1664:
1663:urinary tract
1660:
1656:
1655:advance stage
1652:
1648:
1647:
1641:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1598:
1597:breast cancer
1592:
1590:
1587:
1583:
1580:
1576:
1575:glioblastomas
1572:
1568:
1567:
1566:brain tumours
1561:
1559:
1555:
1551:
1547:
1543:
1539:
1538:
1532:
1530:
1526:
1525:
1521:
1514:
1512:
1508:
1504:
1499:
1498:
1497:breast cancer
1493:
1492:
1487:
1483:
1482:
1478:
1477:
1472:
1468:
1460:
1458:
1456:
1452:
1448:
1443:
1438:
1436:
1432:
1428:
1427:endometriosis
1424:
1423:pathogenicity
1421:
1413:
1408:
1406:
1404:
1401:, GRRP1, and
1400:
1396:
1392:
1387:
1384:
1379:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1350:
1346:
1345:proliferation
1342:
1337:
1335:
1331:
1327:
1323:
1319:
1316:
1315:telencephalic
1312:
1308:
1304:
1301:
1297:
1292:
1290:
1286:
1282:
1278:
1274:
1273:embryogenesis
1270:
1262:
1260:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1231:
1230:Transcription
1227:
1225:
1221:
1217:
1213:
1208:
1200:
1198:
1196:
1192:
1188:
1184:
1183:transcription
1180:
1172:
1170:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1143:tumorigenesis
1140:
1136:
1132:
1128:
1127:
1114:
1109:
1105:
1101:
1098:
1094:
1087:
1085:
1082:
1078:
1074:
1070:
1067:
1063:
1059:
1052:
1050:
1044:
1040:
1037:
1031:
1029:
1023:
1019:
1016:
1012:
1005:
1003:
997:
993:
990:
984:
982:
976:
972:
969:
967:RefSeq (mRNA)
965:
958:
957:
952:
948:
945:
939:
938:
933:
929:
926:
924:
920:
913:
912:
907:
903:
900:
894:
893:
888:
884:
881:
879:
875:
868:
867:
862:
858:
855:
849:
848:
843:
839:
836:
834:
830:
827:
824:
822:
819:
815:
812:
808:
804:
797:
793:
788:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
633:
631:
628:
627:
621:
618:
616:
613:
612:
610:
607:
606:
600:
597:
595:
592:
590:
587:
585:
582:
580:
577:
575:
572:
571:
569:
566:
565:
562:
561:Gene ontology
558:
554:
542:
537:
533:
526:
519:
514:
511:
509:
505:
497:
492:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
444:
441:
437:
432:
429:
419:
415:
412:thyroid gland
411:
407:
404:hair follicle
403:
399:
395:
391:
388:skin of thigh
387:
383:
382:
379:
375:
370:
367:
366:
363:
361:
357:
355:
354:
350:
349:
346:
344:
340:
336:
332:
328:
320:
315:
311:
307:
302:
292:
288:
281:
274:
268:
261:
253:
249:
245:
240:
236:
231:
227:
219:
214:
210:
206:
201:
191:
187:
180:
173:
167:
160:
156:
150:
146:
142:
137:
133:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
76:
71:
64:
59:
54:
50:
45:
40:
36:
34:
19:
8855:
8854:
8842:
8797:
8753:
8711:
8703:
8675:
8669:
8663:
8632:
8597:
8585:
8522:
8499:
8481:
8449:
8420:
8301:
8231:
8205:
8157:
8060:
8007:
7927:
7915:
7869:
7861:
7767:
7713:
7686:
7678:
7649:
7638:
7382:FOX proteins
7342:winged helix
7334:
7305:
7288:
7231:
7151:
7125:
7003:
6969:
6952:
6930:
6913:
6846:
6814:
6668:
6631:
6612:
6558:
6524:
6518:
6212:
6206:
6195:
6189:Antennapedia
6187:
6174:
6162:
6156:
6125:
6083:
6061:
6038:
6017:
5775:
5728:
5674:
5620:
5533:
5511:
5489:
5467:
5450:
5408:
5337:
5219:
5187:
5139:
5111:
5091:
5066:
5029:
4995:Progesterone
4948:
4844:
4692:
4678:
4672:
4656:
4598:
4551:
4543:
4441:
4351:
4300:
4258:
4238:
4218:
4191:
4161:
4134:
3968:
3958:
3941:
3924:
3836:
3792:
3760:
3723:
3580:
3470:
3458:
3357:
3353:
3322:
3318:
3279:
3275:
3234:
3230:
3193:
3189:
3161:
3157:
3118:
3114:
3083:
3079:
3058:
3054:
3026:
3022:
2976:(1): 130–5.
2973:
2969:
2938:
2934:
2897:
2893:
2857:
2853:
2803:
2799:
2789:
2762:
2758:
2748:
2721:
2717:
2707:
2670:
2666:
2656:
2629:
2625:
2585:
2581:
2571:
2526:
2522:
2512:
2485:
2481:
2471:
2426:
2422:
2412:
2395:
2391:
2384:
2351:
2347:
2341:
2306:
2302:
2292:
2260:(1): 51–54.
2257:
2253:
2243:
2208:
2204:
2194:
2167:
2163:
2123:
2119:
2109:
2074:
2070:
2030:
2026:
2016:
2005:. Retrieved
2001:the original
1996:
1992:
1982:
1947:
1943:
1933:
1877:(1): 200–3.
1874:
1870:
1864:
1855:
1846:
1837:
1828:
1760:
1735:
1734:
1714:
1708:
1685:
1683:
1667:renal pelvis
1644:
1642:
1640:epithelium.
1595:
1593:
1573:tumours and
1564:
1562:
1535:
1533:
1520:B lymphocyte
1517:
1515:
1495:
1490:
1485:
1480:
1475:
1464:
1439:
1417:
1380:
1338:
1293:
1268:
1266:
1228:
1224:heterodimers
1206:
1204:
1176:
1167:angiogenesis
1161:, and as an
1125:
1124:
1123:
1046:
1025:
999:
978:
954:
935:
909:
890:
864:
845:
825:
820:
474:aortic valve
358:
351:
78:External IDs
32:
8523:(4.11) Runt
6178:Homeodomain
5776:zinc finger
5112:subfamily 0
5092:subfamily 6
5067:subfamily 5
5030:subfamily 4
4949:subfamily 3
4845:subfamily 2
4693:subfamily 1
4660:Zinc finger
3903:Neurogenins
3471:(1.1) Basic
3325:(1): 15–8.
3231:Mol. Cancer
3188:leukemia".
2164:Development
1721:risk factor
1690:. The ID4
1630:ER negative
1622:ER positive
1610:risk factor
1491:endometrial
1376:neural tube
1372:hippocampus
1352:progenitors
1222:by forming
1191:amino acids
1181:and during
454:optic nerve
400:optic nerve
384:skin of hip
317:48,419,502
304:48,414,704
216:19,842,197
203:19,837,370
56:Identifiers
35:(1996 film)
8872:Categories
7056:POU domain
6196:ANTP class
6126:(2.6) WRKY
5409:GLI family
4544:(1.5) RF-X
4442:(1.4) NF-1
3354:BMC Cancer
3190:Nat. Genet
2673:(16): 16.
2007:2018-06-07
1823:, May 2017
1802:, May 2017
1778:References
1659:urothelium
1614:metastasis
1602:carcinomas
1586:neoplastic
1582:astrocytes
1579:neoplastic
1548:, diffuse
1540:, the ID4
1455:chromosome
1364:cell cycle
1334:epithelium
1309:, and the
1303:myocardium
1151:senescence
362:(ortholog)
99:HomoloGene
18:ID4 (gene)
8843:see also
8684:Apetala 2
7338:Fork head
6018:(2.4) Cys
5220:(2.3) Cys
3952:Scleraxis
3237:(1): 16.
2446:2381/4129
1725:prognosis
1723:for poor
1634:oestrogen
1612:in nodal
1606:specimens
1420:molecular
1356:stem cell
1347:in early
1281:gestation
1173:Structure
1159:apoptosis
1049:NP_112443
1028:NP_001537
1002:NM_031166
981:NM_001546
811:Orthologs
615:cytoplasm
107:GeneCards
8161:MADS box
6301:Homeobox
6213:Hox-like
6207:protoHOX
4968:Estrogen
4963:Androgen
4817:Rev-ErbA
4355:bHLH-ZIP
4330:bHLH-COE
3869:Myogenin
3386:18513385
3341:17510533
3306:16682435
3263:15876350
3210:15723065
3180:15569977
3145:14633621
3102:14534543
3080:Oncogene
3067:12969807
3045:11756408
3010:11136250
2922:23855715
2830:16682435
2781:15897910
2759:Oncogene
2740:14534543
2718:Oncogene
2699:15876350
2648:16687485
2604:16963729
2563:15827123
2504:18371409
2455:17940204
2404:12969807
2368:14631357
2333:22896676
2284:21151130
2235:28794185
2186:15469968
2101:16707840
2093:11731247
1871:Genomics
1819:–
1798:–
1766:See also
1742:X linked
1711:adenomas
1651:amplicon
1554:lymphoid
1518:B-Cell (
1386:mesoderm
1349:cortical
1326:neuronal
1318:vesicles
1311:tail bud
1307:mesoderm
1201:Function
1163:oncogene
1097:Wikidata
790:Sources:
8561:RUNX1T1
8541:CBFA2T3
8536:CBFA2T2
8416:TCF/LEF
6525:NK-like
6519:metaHOX
6222:ParaHox
6163:domains
4854:COUP-TF
4328:Group F
4251:Group E
4184:Group D
4048:Group C
3998:Group B
3942:Paraxis
3807:Group A
3377:2435120
3360:: 154.
3297:1931415
3254:1131921
3136:1892385
2978:Bibcode
2957:9872455
2935:DNA Res
2914:9418957
2884:8759016
2821:1931415
2690:1131921
2531:Bibcode
2463:3181091
2376:3345120
2324:3633234
2275:3019124
2226:5580654
2142:8922523
2049:9516472
1974:8139914
1891:7665172
1821:Ensembl
1800:Ensembl
1679:urethra
1675:bladder
1671:ureters
1626:lesions
1618:mammary
1486:ovarian
1476:primary
1383:cardiac
1330:ventral
1285:central
1233:factors
1218:(bHLH)
1133:coding
1131:protein
923:UniProt
878:Ensembl
817:Species
796:QuickGO
620:nucleus
482:utricle
408:urethra
337:pattern
63:Aliases
7274:Bicoid
6539:BARHL2
6534:BARHL1
6116:JMJD1B
6029:HIVEP1
4514:I-SMAD
4482:R-SMAD
4400:MLXIPL
4155:Period
4081:ARNTL2
3886:NeuroD
3407:(MeSH)
3384:
3374:
3339:
3304:
3294:
3261:
3251:
3218:515916
3216:
3208:
3178:
3143:
3133:
3100:
3065:
3043:
3008:
2998:
2955:
2920:
2912:
2882:
2875:145994
2872:
2828:
2818:
2779:
2738:
2697:
2687:
2646:
2602:
2561:
2554:556127
2551:
2502:
2461:
2453:
2402:
2374:
2366:
2331:
2321:
2282:
2272:
2233:
2223:
2184:
2140:
2099:
2091:
2047:
1972:
1965:307878
1962:
1889:
1740:is an
1511:vagina
1507:cervix
1503:uterus
1435:CDKN1A
1368:cortex
1300:dorsal
1298:, the
1241:dimers
1083:search
1081:PubMed
956:P41139
937:P47928
833:Entrez
508:BioGPS
195:6p22.3
87:600581
8824:Sigma
8689:EREBP
8673:EREBP
8664:(0.5)
8633:(0.3)
8556:RUNX3
8551:RUNX2
8546:RUNX1
8490:TFCP2
8411:SSRP1
8232:(4.7)
8222:TBPL1
8206:(4.6)
8158:(4.4)
8008:(4.2)
7949:NFKB2
7944:NFKB1
7939:NF-κB
7928:(4.1)
7852:MYBL2
7639:(3.4)
7335:(3.3)
7284:BICD2
7259:SHOX2
7227:PROP1
7211:PRRX
7121:SATB2
7066:BRN-3
7061:PIT-1
6953:PKNOX
6868:TALE
6864:NOBOX
6837:HESX1
6810:CUTL1
6792:other
6686:NANOG
6549:BARX2
6544:BARX1
6296:MEOX2
6291:MEOX1
6175:(3.1)
6084:JARID
6057:GRLF1
6052:DIDO1
5712:Zbtb7
5702:TSHZ3
5670:PRDM9
5468:HIVEP
5333:ATBF1
5287:TFIIH
5272:TFIIF
5255:TFIIE
5250:TFIID
5245:TFIIB
5240:TFIIA
5210:TRPS1
5076:LRH-1
5054:NURR1
5044:NGFIB
4872:Ear-2
4673:(2.1)
4415:SREBP
4352:(1.3)
4114:NPAS
4103:EPAS1
4088:CLOCK
4076:ARNTL
4050:bHLH-
4026:n-Myc
4021:l-Myc
4016:c-Myc
4006:FIGLA
3988:Twist
3947:TCF15
3854:MESP2
3832:ATOH1
3825:ASCL2
3820:ASCL1
3751:NFIL3
3682:GABPA
3677:DDIT3
3608:C/EBP
3603:BLZF1
3564:c-Jun
3554:FOSL2
3549:FOSL1
3539:c-Fos
3214:S2CID
3001:14556
2918:S2CID
2459:S2CID
2423:Blood
2372:S2CID
2097:S2CID
1467:ovary
1431:HOXA9
1403:MESP1
1395:FOXA2
1179:exons
1129:is a
866:15904
826:Mouse
821:Human
792:Amigo
360:Mouse
353:Human
300:Start
235:Mouse
199:Start
132:Human
95:99414
8793:MNDA
8712:ARID
8667:AP-2
8654:RBL2
8649:RBL1
8623:HBP1
8606:HMGA
8513:YBX1
8508:CSDA
8443:LEF1
8275:HMGN
8248:HMGB
8169:Mef2
8148:MYRF
8136:TBR2
8131:TBR1
8079:TP63
8019:STAT
8011:STAT
7971:NFAT
7964:RELB
7959:RELA
7914:(4)
7795:FLI1
7761:SPIB
7462:D4L6
7457:D4L5
7452:D4L4
7447:D4L3
7442:D4L1
7306:PITX
7269:VSX2
7264:VSX1
7254:SHOX
7232:PHOX
6914:MEIS
6842:HOPX
6778:VAX2
6773:VAX1
6768:TLX3
6763:TLX2
6758:TLX1
6753:NATO
6736:HMX3
6731:HMX2
6726:HMX1
6664:LBX2
6659:LBX1
6649:HHEX
6508:MNX1
6503:GBX2
6498:GBX1
6286:Evx2
6281:Evx1
6249:PDX1
6244:Xlox
6134:WRKY
6047:AIRE
6006:804A
5729:ZBTB
5675:SALL
5665:OSR1
5660:MYT1
5655:MTF1
5490:IKZF
5429:REST
5404:GFI1
5399:ERV3
5367:E4F1
5362:CTCF
5151:GATA
5121:DAX1
5101:GCNF
5049:NOR1
4877:HNF4
4746:PPAR
4679:(Cys
4607:AP-2
4477:SMAD
4432:USF1
4405:MXI1
4385:MITF
4378:MXD3
4373:MXD1
4363:AP-4
4338:EBF1
4214:Pho4
4192:BHLH
4071:ARNT
4066:AHRR
4038:TCF4
4033:MXD4
3964:LYL1
3925:OLIG
3879:MYF6
3874:MYF5
3864:MyoD
3837:HAND
3815:AS-C
3797:bHLH
3783:XBP1
3687:GCN4
3667:CREM
3645:CREB
3598:BATF
3581:BACH
3574:JunD
3569:JUNB
3559:JDP2
3544:FOSB
3534:AP-1
3492:AATF
3478:bZIP
3444:and
3382:PMID
3337:PMID
3302:PMID
3259:PMID
3206:PMID
3176:PMID
3141:PMID
3098:PMID
3063:PMID
3041:PMID
3006:PMID
2953:PMID
2910:PMID
2880:PMID
2826:PMID
2777:PMID
2736:PMID
2695:PMID
2644:PMID
2600:PMID
2559:PMID
2500:PMID
2451:PMID
2400:PMID
2364:PMID
2329:PMID
2280:PMID
2231:PMID
2182:PMID
2138:PMID
2089:PMID
2045:PMID
1970:PMID
1887:PMID
1552:and
1509:and
1494:and
1469:and
1451:loci
1433:and
1399:EVX1
1393:and
1391:TCF3
1370:and
1341:G1-S
1320:and
1287:and
1275:and
1267:The
1205:The
1187:mRNA
1185:its
1141:and
1135:gene
847:3400
343:Bgee
291:Band
252:Chr.
190:Band
149:Chr.
103:1186
83:OMIM
8820:Rho
8798:NFY
8771:MLL
8754:IFI
8749:CAP
8531:CBF
8450:TOX
8421:TCF
8406:SRY
8319:SOX
8302:HNF
8243:BBX
8217:TBP
8196:SRF
8141:TFT
8091:TBX
8084:p73
8074:p53
7954:REL
7847:MYB
7768:ETV
7756:ERG
7741:ETS
7736:ERF
7714:ELK
7709:EGF
7687:ELF
7651:HSF
7350:E2F
7289:OTX
7279:GSC
7249:RAX
7160:PAX
7126:ZEB
7099:3/4
7049:21A
7004:PHF
6970:SIX
6931:PBX
6907:MKX
6872:IRX
6847:LMX
6815:FHL
6805:CRX
6800:ARX
6746:6-2
6741:6-1
6721:3-2
6716:3-1
6711:2-5
6706:2-3
6701:2-2
6696:2-1
6691:NKX
6669:MSX
6654:HLX
6614:EMX
6576:DLX
6559:DBX
6554:BSX
6491:D13
6486:D12
6481:D11
6476:D10
6446:C13
6441:C12
6436:C11
6431:C10
6401:B13
6351:A13
6346:A11
6341:A10
6256:Cdx
6227:Gsx
6157:(3)
6062:ING
6001:655
5996:649
5991:644
5986:638
5981:593
5976:471
5971:452
5966:451
5961:423
5956:384
5951:366
5946:365
5941:350
5936:346
5931:330
5926:318
5921:300
5916:281
5911:268
5906:267
5901:259
5896:239
5891:238
5886:219
5881:217
5876:202
5871:165
5866:148
5861:146
5856:143
5816:33B
5707:WT1
5534:KLF
5512:ILF
5451:HIC
5444:YY1
5372:EGR
5355:11B
5350:11A
5339:BCL
5322:3C2
5317:3C1
5224:His
5188:MTA
5126:SHP
5081:SF1
5039:NUR
4938:TLX
4899:RXR
4894:PNR
4834:VDR
4795:ROR
4773:RAR
4768:PXR
4756:β/δ
4729:LXR
4724:FXR
4719:CAR
4657:(2)
4587:ANK
4552:RFX
4450:NFI
4410:Myc
4395:MLX
4390:MNT
4368:MAX
4301:HEY
4259:HES
4162:SIM
4135:PER
4093:HIF
4061:AhR
4052:PAS
4011:Myc
3969:TAL
3959:SLC
3761:NRF
3756:NRL
3724:NFE
3697:MAF
3692:HLF
3672:DBP
3372:PMC
3362:doi
3327:doi
3292:PMC
3284:doi
3249:PMC
3239:doi
3198:doi
3166:doi
3131:PMC
3123:doi
3119:163
3088:doi
3031:doi
3027:277
2996:PMC
2986:doi
2943:doi
2902:doi
2870:PMC
2862:doi
2816:PMC
2808:doi
2767:doi
2726:doi
2685:PMC
2675:doi
2634:doi
2590:doi
2549:PMC
2539:doi
2527:102
2490:doi
2441:hdl
2431:doi
2427:111
2356:doi
2319:PMC
2311:doi
2270:PMC
2262:doi
2221:PMC
2213:doi
2172:doi
2168:131
2128:doi
2124:207
2079:doi
2075:109
2035:doi
2031:273
1960:PMC
1952:doi
1879:doi
1713:of
1628:.
1563:In
1534:In
1529:IgH
1516:In
1449:at
1425:of
1405:).
1360:RB1
1269:ID4
1255:by
1207:ID4
1165:in
1126:ID4
313:End
212:End
115:OMA
111:ID4
91:MGI
70:ID4
47:ID4
8874::
8786:T1
8764:35
8759:16
8742:4A
8737:3B
8732:3A
8722:1B
8717:1A
8694:B3
8644:Rb
8399:21
8394:18
8389:15
8384:14
8379:13
8374:12
8369:11
8364:10
8312:1B
8307:1A
8126:22
8121:21
8116:19
7991:C4
7986:C3
7981:C2
7976:C1
7627:S1
7622:R2
7617:R1
7612:Q1
7607:P4
7602:P3
7597:P2
7592:P1
7587:O6
7582:O4
7577:O3
7572:O1
7567:N4
7562:N3
7557:N2
7552:N1
7547:M1
7542:L2
7537:L1
7532:K2
7527:K1
7522:J3
7517:J2
7512:J1
7507:I3
7502:I2
7497:I1
7492:H1
7487:G1
7482:F2
7477:F1
7472:E3
7467:E1
7437:D4
7432:D3
7427:D2
7422:D1
7417:C2
7412:C1
7407:B2
7402:B1
7397:A3
7392:A2
7387:A1
7340:/
7242:2B
7237:2A
7114:11
7087::
7068::
7044:20
7039:17
7034:16
7029:10
6857:1B
6852:1A
6632:EN
6471:D9
6466:D8
6461:D4
6456:D3
6451:D1
6426:C9
6421:C8
6416:C6
6411:C5
6406:C4
6396:B9
6391:B8
6386:B7
6381:B6
6376:B5
6371:B4
6366:B3
6361:B2
6356:B1
6336:A9
6331:A7
6326:A5
6321:A4
6316:A3
6311:A2
6306:A1
6104:1D
6099:1C
6094:1B
6089:1A
5851:74
5846:51
5841:44
5836:43
5831:41
5826:35
5821:34
5811:24
5806:22
5801:19
5796:10
5769:40
5764:33
5759:32
5754:21
5749:20
5744:17
5739:16
5734:11
5722:7B
5717:7A
5621:SP
5614:17
5609:15
5604:14
5599:13
5594:12
5589:11
5584:10
5439:S2
5434:S1
5312:3A
5307:2I
4865:II
4219:ID
4108:3A
4098:1A
3744:L3
3739:L2
3734:L1
3660:L1
3380:.
3370:.
3356:.
3352:.
3335:.
3323:47
3321:.
3317:.
3300:.
3290:.
3280:15
3278:.
3274:.
3257:.
3247:.
3233:.
3229:.
3212:.
3204:.
3194:37
3192:.
3174:.
3162:10
3160:.
3156:.
3139:.
3129:.
3117:.
3113:.
3096:.
3084:22
3082:.
3078:.
3059:88
3057:.
3039:.
3025:.
3021:.
3004:.
2994:.
2984:.
2974:98
2972:.
2968:.
2951:.
2937:.
2933:.
2916:.
2908:.
2898:50
2896:.
2878:.
2868:.
2858:24
2856:.
2852:.
2824:.
2814:.
2804:15
2802:.
2798:.
2775:.
2763:24
2761:.
2757:.
2734:.
2722:22
2720:.
2716:.
2693:.
2683:.
2669:.
2665:.
2642:.
2628:.
2624:.
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2425:.
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2305:.
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2252:.
2229:.
2219:.
2209:31
2207:.
2203:.
2180:.
2166:.
2162:.
2150:^
2136:.
2122:.
2118:.
2095:.
2087:.
2073:.
2069:.
2057:^
2043:.
2029:.
2025:.
1995:.
1991:.
1968:.
1958:.
1948:22
1946:.
1942:.
1916:^
1899:^
1885:.
1875:27
1873:.
1854:.
1836:.
1807:^
1786:^
1673:,
1669:,
1591:.
1560:.
1522:)
1513:.
1505:,
1488:,
1440:A
1243:.
1169:.
1157:,
1153:,
1149:,
794:/
319:bp
306:bp
218:bp
205:bp
113:;
109::
105:;
101::
97:;
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89:;
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8864:.
8822:/
8813:C
8808:B
8803:A
8781:3
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8616:2
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8465:3
8460:2
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8426:1
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8280:1
8268:4
8263:3
8258:2
8253:1
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8179:B
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