336:
313:
210:
235:
2379:
2364:
2349:
594:
587:
31:
342:
241:
2023:
Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000).
2022:
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W,
57:
2203:"STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues"
2103:"The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor"
1402:"The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor"
2171:
Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening".
2378:
3009:
2363:
2348:
1812:"Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor"
349:
248:
1697:"Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster"
3132:
2419:
842:
171:
823:
2809:
3380:
3098:
3094:
3077:
3211:
3186:
3050:
3422:
3215:
3190:
3041:
2328:
1322:
1304:
3368:
3067:
3002:
1658:
Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness".
335:
54:
3062:
1106:
2068:"Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor"
1443:"Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor"
1113:
312:
2273:"Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells"
1482:
Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2".
2941:
2646:
2638:
2412:
1383:
1340:
Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning".
1740:"Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling"
3289:
2587:
1291:
1270:
1958:
Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2".
3284:
3232:
2623:
1192:
234:
209:
1287:
1773:
Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor".
2536:
2498:
2493:
1882:"The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein"
1266:
2541:
151:
1695:
Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE (1995).
3253:
3249:
2405:
1216:
348:
247:
2954:
3269:
2885:
2441:
341:
240:
2387:: NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human Interferon alpha-2
3245:
3169:
2868:
2654:
2321:
1917:"Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling"
1522:"Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling"
1989:"Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2"
3399:
3363:
2894:
887:
159:
3318:
3296:
3220:
3207:
3194:
3182:
3150:
3137:
3127:
3103:
3090:
3046:
3037:
2964:
2937:
2928:
2523:
1188:
868:
3355:
3279:
3032:
2998:
2989:
2959:
2950:
2933:
2531:
2451:
2138:"Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling"
1571:"Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling"
3057:
223:
1207:. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
2238:"Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors"
3177:
3085:
3027:
2984:
2911:
2314:
2036:
1196:
138:
3394:
3389:
3227:
1085:
1081:
1046:
1042:
1038:
1014:
1006:
985:
981:
967:
963:
959:
3384:
3155:
2903:
2436:
1798:
1683:
1646:
1365:
183:
2372:: Average structure of the interferon-binding ectodomain of the human type I interferon receptor
1089:
1060:
1050:
1034:
1010:
977:
955:
951:
593:
586:
2428:
2294:
2259:
2224:
2189:
2159:
2124:
2089:
2054:
2010:
1975:
1946:
1903:
1868:
1833:
1790:
1761:
1726:
1675:
1638:
1592:
1551:
1499:
1464:
1423:
1357:
131:
47:
3343:
3146:
3019:
2860:
2852:
2753:
2745:
2737:
2729:
2284:
2249:
2214:
2181:
2149:
2114:
2079:
2044:
2000:
1967:
1936:
1928:
1893:
1858:
1823:
1782:
1751:
1716:
1708:
1667:
1628:
1582:
1541:
1533:
1491:
1454:
1413:
1349:
428:
359:
303:
258:
179:
142:, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
2769:
1987:
Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999).
403:
2040:
30:
2670:
1738:
Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995).
1712:
1941:
1916:
1721:
1696:
1546:
1521:
757:
752:
747:
742:
737:
732:
727:
722:
717:
701:
696:
691:
686:
681:
676:
671:
655:
650:
645:
640:
635:
3416:
3122:
2916:
2357:: NMR structure of the interferon-binding ectodomain of the human interferon receptor
1615:
Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005).
1441:
Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000).
1400:
Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001).
1369:
1353:
622:
1802:
163:
3310:
2678:
1650:
421:
200:
1687:
1569:
Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (March 2002).
187:
2503:
2478:
2289:
2272:
2254:
2237:
2101:
Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (2001).
2084:
2067:
1459:
1442:
1327:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1309:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2005:
1988:
504:
320:
217:
167:
1898:
1881:
1828:
1811:
1756:
1739:
2793:
2785:
2777:
2066:
Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (2000).
1847:"Normalization and subtraction: two approaches to facilitate gene discovery"
787:
564:
442:
387:
374:
286:
273:
175:
2298:
2263:
2228:
2219:
2202:
2193:
2163:
2154:
2137:
2136:
Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (2002).
2128:
2119:
2102:
2093:
2058:
2014:
1979:
1971:
1642:
1596:
1587:
1570:
1503:
1495:
1468:
1427:
1418:
1401:
1950:
1932:
1907:
1872:
1837:
1794:
1765:
1730:
1679:
1555:
1537:
1361:
1153:
1148:
2833:
2825:
2817:
2801:
1786:
1137:
932:
913:
1880:
Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996).
3202:
3198:
2945:
1863:
1846:
1671:
1169:
899:
854:
2185:
1633:
1616:
108:
104:
100:
96:
92:
88:
84:
80:
76:
3338:
3333:
3328:
3323:
3300:
3236:
2976:
2609:
2397:
2049:
2024:
1223:
1121:
809:
1384:"Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2"
3373:
2993:
2924:
2920:
2710:
2662:
2604:
2568:
2563:
2558:
2553:
2548:
2513:
2473:
2463:
1617:"Alpha-interferon and its effects on signal transduction pathways"
1241:
1235:
1229:
1204:
1200:
772:
768:
2761:
2702:
2694:
2686:
2597:
2508:
2488:
2483:
2468:
2459:
1176:
155:
2401:
2310:
602:
2306:
2271:
Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002).
2201:
Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002).
1199:, which in turn phosphorylate several proteins, including
733:
regulation of type I interferon-mediated signaling pathway
1810:
Platanias LC, Uddin S, Domanski P, Colamonici OR (1996).
411:
2236:
Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002).
576:
1195:. Binding and activation of the receptor stimulates
3354:
3309:
3268:
3168:
3114:
3076:
3018:
2975:
2902:
2893:
2884:
2845:
2722:
2631:
2622:
2577:
2522:
2450:
2435:
1074:
1033:
999:
950:
1283:
1281:
1279:
1262:
1260:
1258:
358:
257:
1520:Li X, Leung S, Kerr IM, Stark GR (April 1997).
18:Protein-coding gene in the species Homo sapiens
1515:
1513:
1395:
1393:
1288:GRCm38: Ensembl release 89: ENSMUSG00000022971
2413:
2322:
8:
1267:GRCh38: Ensembl release 89: ENSG00000159110
2899:
2890:
2628:
2447:
2420:
2406:
2398:
2329:
2315:
2307:
1030:
947:
783:
618:
399:
298:
195:
65:
2288:
2253:
2218:
2153:
2118:
2083:
2048:
2025:"The DNA sequence of human chromosome 21"
2004:
1940:
1915:Li X, Leung S, Kerr IM, Stark GR (1997).
1897:
1862:
1827:
1755:
1720:
1632:
1586:
1545:
1458:
1417:
1166:Interferon-alpha/beta receptor beta chain
1845:Bonaldo MF, Lennon G, Soares MB (1996).
2344:
1254:
1193:receptor for interferons alpha and beta
728:receptor signaling pathway via JAK-STAT
718:cell surface receptor signaling pathway
1191:that forms one of the two chains of a
1187:The protein encoded by this gene is a
20:
687:integral component of plasma membrane
363:
324:
319:
262:
221:
216:
7:
758:cytokine-mediated signaling pathway
738:type I interferon signaling pathway
651:type I interferon receptor activity
1713:10.1002/j.1460-2075.1995.tb00192.x
1071:
996:
923:
904:
878:
859:
833:
814:
697:intracellular anatomical structure
581:
499:
437:
416:
14:
1172:that in humans is encoded by the
2377:
2362:
2347:
592:
585:
347:
340:
334:
311:
246:
239:
233:
208:
29:
672:integral component of membrane
603:More reference expression data
565:More reference expression data
1:
332:
231:
3423:Genes on human chromosome 21
1354:10.1016/0092-8674(94)90154-6
743:response to interferon-alpha
2290:10.4049/jimmunol.169.6.3038
2255:10.4049/jimmunol.169.3.1302
2085:10.4049/jimmunol.165.9.5127
1460:10.4049/jimmunol.165.9.5127
748:response to interferon-beta
3439:
2006:10.4049/jimmunol.163.2.766
656:cytokine receptor activity
2342:
1323:"Mouse PubMed Reference:"
1305:"Human PubMed Reference:"
1215:IFNAR2 has been shown to
1152:
1147:
1143:
1136:
1120:
1101:
1078:
1057:
1026:
1003:
974:
943:
930:
926:
911:
907:
898:
885:
881:
866:
862:
853:
840:
836:
821:
817:
808:
793:
786:
782:
766:
753:defense response to virus
641:type I interferon binding
621:
617:
600:
584:
575:
562:
511:
502:
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
73:
68:
51:
46:
41:
37:
28:
23:
1899:10.1074/jbc.271.52.33165
1829:10.1074/jbc.271.39.23630
1757:10.1074/jbc.270.37.21606
1107:Chr 21: 33.21 – 33.27 Mb
365:16 C3.3|16 52.82 cM
1189:type I membrane protein
1114:Chr 16: 91.17 – 91.2 Mb
547:internal carotid artery
3356:Enzyme-linked receptor
2220:10.1074/jbc.M204578200
2155:10.1074/jbc.M111161200
2120:10.1074/jbc.M100087200
1972:10.1006/jmbi.1999.2726
1660:Somat. Cell Mol. Genet
1588:10.1074/jbc.M111161200
1496:10.1006/jmbi.1999.2726
1419:10.1074/jbc.M100087200
646:protein kinase binding
543:mesenteric lymph nodes
3178:Interleukin receptors
3086:Interleukin receptors
3028:Interleukin receptors
2985:Interleukin receptors
2912:Interleukin receptors
1933:10.1128/mcb.17.4.2048
1538:10.1128/mcb.17.4.2048
1197:Janus protein kinases
326:Chromosome 16 (mouse)
224:Chromosome 21 (human)
3228:Interferon receptors
1787:10.1002/jlb.57.5.712
677:extracellular region
69:List of PDB id codes
42:Available structures
2041:2000Natur.405..311H
702:extracellular space
519:right lobe of liver
485:islet of Langerhans
2437:Chemokine receptor
2429:Cytokine receptors
1864:10.1101/gr.6.9.791
1672:10.1007/BF02255789
888:ENSMUSG00000022971
711:Biological process
665:Cellular component
629:Molecular function
188:IFNAR2 - orthologs
3410:
3409:
3264:
3263:
3164:
3163:
2880:
2879:
2618:
2617:
2395:
2394:
2186:10.1021/bi011778f
1634:10.1002/jcp.20137
1163:
1162:
1159:
1158:
1132:
1131:
1097:
1096:
1068:
1067:
1022:
1021:
993:
992:
939:
938:
920:
919:
894:
893:
875:
874:
849:
848:
830:
829:
778:
777:
723:response to virus
613:
612:
609:
608:
571:
570:
558:
557:
496:
495:
394:
393:
293:
292:
120:
119:
116:
115:
52:Ortholog search:
3430:
3147:hormone receptor
2900:
2891:
2629:
2448:
2422:
2415:
2408:
2399:
2381:
2366:
2351:
2331:
2324:
2317:
2308:
2302:
2292:
2267:
2257:
2232:
2222:
2213:(38): 35635–41.
2197:
2167:
2157:
2132:
2122:
2113:(25): 22948–53.
2097:
2087:
2062:
2052:
2050:10.1038/35012518
2018:
2008:
1983:
1954:
1944:
1911:
1901:
1876:
1866:
1841:
1831:
1806:
1769:
1759:
1750:(37): 21606–11.
1734:
1724:
1691:
1654:
1636:
1621:J. Cell. Physiol
1601:
1600:
1590:
1566:
1560:
1559:
1549:
1517:
1508:
1507:
1479:
1473:
1472:
1462:
1438:
1432:
1431:
1421:
1412:(25): 22948–53.
1397:
1388:
1387:
1380:
1374:
1373:
1337:
1331:
1330:
1319:
1313:
1312:
1301:
1295:
1285:
1274:
1264:
1145:
1144:
1116:
1109:
1092:
1072:
1063:
1031:
1027:RefSeq (protein)
1017:
997:
988:
948:
924:
905:
879:
860:
834:
815:
784:
619:
605:
596:
589:
582:
567:
531:genital tubercle
507:
505:Top expressed in
500:
477:cartilage tissue
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
141:
134:
111:
66:
60:
39:
38:
33:
21:
3438:
3437:
3433:
3432:
3431:
3429:
3428:
3427:
3413:
3412:
3411:
3406:
3350:
3305:
3260:
3160:
3110:
3072:
3014:
2971:
2876:
2841:
2770:Osteoprotegerin
2718:
2614:
2573:
2518:
2439:
2431:
2426:
2396:
2391:
2388:
2382:
2373:
2367:
2358:
2352:
2338:
2335:
2305:
2270:
2235:
2200:
2180:(11): 3575–85.
2170:
2148:(12): 9713–21.
2135:
2100:
2065:
2035:(6784): 311–9.
2021:
1986:
1957:
1921:Mol. Cell. Biol
1914:
1892:(52): 33165–8.
1879:
1844:
1822:(39): 23630–3.
1809:
1775:J. Leukoc. Biol
1772:
1737:
1694:
1657:
1614:
1610:
1608:Further reading
1605:
1604:
1581:(12): 9713–21.
1568:
1567:
1563:
1526:Mol. Cell. Biol
1519:
1518:
1511:
1481:
1480:
1476:
1440:
1439:
1435:
1399:
1398:
1391:
1382:
1381:
1377:
1339:
1338:
1334:
1321:
1320:
1316:
1303:
1302:
1298:
1286:
1277:
1265:
1256:
1251:
1213:
1185:
1154:View/Edit Mouse
1149:View/Edit Human
1112:
1105:
1102:Location (UCSC)
1088:
1084:
1080:
1059:
1053:
1049:
1045:
1041:
1037:
1013:
1009:
1005:
984:
980:
976:
970:
966:
962:
958:
954:
869:ENSG00000159110
762:
706:
682:plasma membrane
660:
636:protein binding
601:
591:
590:
563:
554:
549:
545:
541:
537:
533:
529:
525:
521:
517:
503:
492:
487:
483:
479:
475:
471:
469:trabecular bone
467:
463:
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
75:
53:
19:
12:
11:
5:
3436:
3434:
3426:
3425:
3415:
3414:
3408:
3407:
3405:
3404:
3403:
3402:
3397:
3392:
3378:
3377:
3376:
3371:
3360:
3358:
3352:
3351:
3349:
3348:
3347:
3346:
3341:
3336:
3331:
3326:
3315:
3313:
3307:
3306:
3304:
3303:
3294:
3293:
3292:
3287:
3277:
3274:
3272:
3270:Ig superfamily
3266:
3265:
3262:
3261:
3259:
3258:
3257:
3256:
3243:
3225:
3224:
3223:
3218:
3205:
3174:
3172:
3166:
3165:
3162:
3161:
3159:
3158:
3153:
3143:
3142:
3141:
3140:
3138:Thrombopoietin
3135:
3130:
3118:
3116:
3112:
3111:
3109:
3108:
3107:
3106:
3101:
3082:
3080:
3074:
3073:
3071:
3070:
3065:
3060:
3055:
3054:
3053:
3044:
3035:
3024:
3022:
3016:
3015:
3013:
3012:
3007:
3006:
3005:
2996:
2981:
2979:
2973:
2972:
2970:
2969:
2968:
2967:
2962:
2957:
2948:
2931:
2908:
2906:
2897:
2888:
2882:
2881:
2878:
2877:
2875:
2874:
2866:
2858:
2849:
2847:
2843:
2842:
2840:
2839:
2831:
2823:
2815:
2807:
2799:
2791:
2783:
2775:
2767:
2759:
2751:
2743:
2735:
2726:
2724:
2720:
2719:
2717:
2716:
2708:
2700:
2692:
2684:
2676:
2668:
2660:
2652:
2644:
2635:
2633:
2626:
2620:
2619:
2616:
2615:
2613:
2612:
2607:
2602:
2601:
2600:
2592:
2591:
2590:
2581:
2579:
2575:
2574:
2572:
2571:
2566:
2561:
2556:
2551:
2546:
2545:
2544:
2539:
2528:
2526:
2520:
2519:
2517:
2516:
2511:
2506:
2501:
2496:
2491:
2486:
2481:
2476:
2471:
2466:
2456:
2454:
2445:
2433:
2432:
2427:
2425:
2424:
2417:
2410:
2402:
2393:
2392:
2390:
2389:
2383:
2376:
2374:
2368:
2361:
2359:
2353:
2346:
2343:
2340:
2339:
2336:
2334:
2333:
2326:
2319:
2311:
2304:
2303:
2283:(6): 3038–45.
2268:
2233:
2198:
2168:
2133:
2098:
2078:(9): 5127–32.
2063:
2019:
1984:
1955:
1927:(4): 2048–56.
1912:
1877:
1857:(9): 791–806.
1842:
1807:
1770:
1735:
1707:(20): 5100–8.
1692:
1655:
1611:
1609:
1606:
1603:
1602:
1561:
1532:(4): 2048–56.
1509:
1474:
1453:(9): 5127–32.
1433:
1389:
1375:
1348:(3): 391–400.
1332:
1314:
1296:
1275:
1253:
1252:
1250:
1247:
1246:
1245:
1239:
1233:
1227:
1212:
1209:
1184:
1181:
1161:
1160:
1157:
1156:
1151:
1141:
1140:
1134:
1133:
1130:
1129:
1127:
1125:
1118:
1117:
1110:
1103:
1099:
1098:
1095:
1094:
1076:
1075:
1069:
1066:
1065:
1055:
1054:
1028:
1024:
1023:
1020:
1019:
1001:
1000:
994:
991:
990:
972:
971:
945:
941:
940:
937:
936:
928:
927:
921:
918:
917:
909:
908:
902:
896:
895:
892:
891:
883:
882:
876:
873:
872:
864:
863:
857:
851:
850:
847:
846:
838:
837:
831:
828:
827:
819:
818:
812:
806:
805:
800:
795:
791:
790:
780:
779:
776:
775:
764:
763:
761:
760:
755:
750:
745:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
679:
674:
668:
666:
662:
661:
659:
658:
653:
648:
643:
638:
632:
630:
626:
625:
615:
614:
611:
610:
607:
606:
598:
597:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
527:tail of embryo
524:
520:
516:
512:
509:
508:
497:
494:
493:
491:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
148:
144:
143:
135:
127:
126:
122:
121:
118:
117:
114:
113:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3435:
3424:
3421:
3420:
3418:
3401:
3398:
3396:
3393:
3391:
3388:
3387:
3386:
3382:
3379:
3375:
3372:
3370:
3367:
3366:
3365:
3362:
3361:
3359:
3357:
3353:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3321:
3320:
3317:
3316:
3314:
3312:
3308:
3302:
3298:
3295:
3291:
3288:
3286:
3283:
3282:
3281:
3278:
3276:
3275:
3273:
3271:
3267:
3255:
3251:
3247:
3244:
3242:
3238:
3234:
3231:
3230:
3229:
3226:
3222:
3219:
3217:
3213:
3209:
3206:
3204:
3200:
3196:
3192:
3188:
3184:
3181:
3180:
3179:
3176:
3175:
3173:
3171:
3167:
3157:
3154:
3152:
3148:
3145:
3144:
3139:
3136:
3134:
3131:
3129:
3126:
3125:
3124:
3123:CSF receptors
3120:
3119:
3117:
3113:
3105:
3102:
3100:
3096:
3092:
3089:
3088:
3087:
3084:
3083:
3081:
3079:
3075:
3069:
3066:
3064:
3061:
3059:
3056:
3052:
3048:
3045:
3043:
3039:
3036:
3034:
3031:
3030:
3029:
3026:
3025:
3023:
3021:
3017:
3011:
3008:
3004:
3000:
2997:
2995:
2991:
2988:
2987:
2986:
2983:
2982:
2980:
2978:
2974:
2966:
2963:
2961:
2958:
2956:
2952:
2949:
2947:
2943:
2939:
2935:
2932:
2930:
2926:
2922:
2918:
2915:
2914:
2913:
2910:
2909:
2907:
2905:
2901:
2898:
2896:
2892:
2889:
2887:
2883:
2873:
2870:
2867:
2865:
2862:
2859:
2857:
2854:
2851:
2850:
2848:
2844:
2838:
2835:
2832:
2830:
2827:
2824:
2822:
2819:
2816:
2814:
2811:
2808:
2806:
2803:
2800:
2798:
2795:
2792:
2790:
2787:
2784:
2782:
2779:
2776:
2774:
2771:
2768:
2766:
2763:
2760:
2758:
2755:
2752:
2750:
2747:
2744:
2742:
2739:
2736:
2734:
2731:
2728:
2727:
2725:
2721:
2715:
2712:
2709:
2707:
2704:
2701:
2699:
2696:
2693:
2691:
2688:
2685:
2683:
2680:
2677:
2675:
2672:
2669:
2667:
2664:
2661:
2659:
2656:
2653:
2651:
2648:
2645:
2643:
2640:
2637:
2636:
2634:
2630:
2627:
2625:
2621:
2611:
2608:
2606:
2603:
2599:
2596:
2595:
2593:
2589:
2586:
2585:
2583:
2582:
2580:
2576:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2543:
2540:
2538:
2535:
2534:
2533:
2530:
2529:
2527:
2525:
2521:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2461:
2458:
2457:
2455:
2453:
2449:
2446:
2443:
2438:
2434:
2430:
2423:
2418:
2416:
2411:
2409:
2404:
2403:
2400:
2386:
2380:
2375:
2371:
2365:
2360:
2356:
2350:
2345:
2341:
2332:
2327:
2325:
2320:
2318:
2313:
2312:
2309:
2300:
2296:
2291:
2286:
2282:
2278:
2274:
2269:
2265:
2261:
2256:
2251:
2248:(3): 1302–8.
2247:
2243:
2239:
2234:
2230:
2226:
2221:
2216:
2212:
2208:
2207:J. Biol. Chem
2204:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2169:
2165:
2161:
2156:
2151:
2147:
2143:
2142:J. Biol. Chem
2139:
2134:
2130:
2126:
2121:
2116:
2112:
2108:
2107:J. Biol. Chem
2104:
2099:
2095:
2091:
2086:
2081:
2077:
2073:
2069:
2064:
2060:
2056:
2051:
2046:
2042:
2038:
2034:
2030:
2026:
2020:
2016:
2012:
2007:
2002:
1999:(2): 766–73.
1998:
1994:
1990:
1985:
1981:
1977:
1973:
1969:
1965:
1961:
1956:
1952:
1948:
1943:
1938:
1934:
1930:
1926:
1922:
1918:
1913:
1909:
1905:
1900:
1895:
1891:
1887:
1886:J. Biol. Chem
1883:
1878:
1874:
1870:
1865:
1860:
1856:
1852:
1848:
1843:
1839:
1835:
1830:
1825:
1821:
1817:
1816:J. Biol. Chem
1813:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1776:
1771:
1767:
1763:
1758:
1753:
1749:
1745:
1744:J. Biol. Chem
1741:
1736:
1732:
1728:
1723:
1718:
1714:
1710:
1706:
1702:
1698:
1693:
1689:
1685:
1681:
1677:
1673:
1669:
1666:(2): 139–45.
1665:
1661:
1656:
1652:
1648:
1644:
1640:
1635:
1630:
1627:(2): 323–35.
1626:
1622:
1618:
1613:
1612:
1607:
1598:
1594:
1589:
1584:
1580:
1576:
1575:J. Biol. Chem
1572:
1565:
1562:
1557:
1553:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1516:
1514:
1510:
1505:
1501:
1497:
1493:
1489:
1485:
1478:
1475:
1470:
1466:
1461:
1456:
1452:
1448:
1444:
1437:
1434:
1429:
1425:
1420:
1415:
1411:
1407:
1406:J. Biol. Chem
1403:
1396:
1394:
1390:
1385:
1379:
1376:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1336:
1333:
1328:
1324:
1318:
1315:
1310:
1306:
1300:
1297:
1293:
1289:
1284:
1282:
1280:
1276:
1272:
1268:
1263:
1261:
1259:
1255:
1248:
1243:
1240:
1237:
1234:
1231:
1228:
1225:
1222:
1221:
1220:
1218:
1210:
1208:
1206:
1202:
1198:
1194:
1190:
1182:
1180:
1178:
1175:
1171:
1167:
1155:
1150:
1146:
1142:
1139:
1135:
1128:
1126:
1123:
1119:
1115:
1111:
1108:
1104:
1100:
1093:
1091:
1087:
1083:
1077:
1073:
1070:
1064:
1062:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1029:
1025:
1018:
1016:
1012:
1008:
1002:
998:
995:
989:
987:
983:
979:
973:
969:
965:
961:
957:
953:
949:
946:
944:RefSeq (mRNA)
942:
935:
934:
929:
925:
922:
916:
915:
910:
906:
903:
901:
897:
890:
889:
884:
880:
877:
871:
870:
865:
861:
858:
856:
852:
845:
844:
839:
835:
832:
826:
825:
820:
816:
813:
811:
807:
804:
801:
799:
796:
792:
789:
785:
781:
774:
770:
765:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
669:
667:
664:
663:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
633:
631:
628:
627:
624:
623:Gene ontology
620:
616:
604:
599:
595:
588:
583:
580:
578:
574:
566:
561:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3311:IL 17 family
3240:
2871:
2863:
2855:
2836:
2828:
2820:
2812:
2804:
2796:
2788:
2780:
2772:
2764:
2756:
2748:
2740:
2732:
2713:
2705:
2697:
2689:
2681:
2679:Fas receptor
2673:
2665:
2657:
2649:
2641:
2624:TNF receptor
2384:
2369:
2354:
2280:
2276:
2245:
2241:
2210:
2206:
2177:
2174:Biochemistry
2173:
2145:
2141:
2110:
2106:
2075:
2071:
2032:
2028:
1996:
1992:
1966:(1): 57–67.
1963:
1960:J. Mol. Biol
1959:
1924:
1920:
1889:
1885:
1854:
1850:
1819:
1815:
1781:(5): 712–8.
1778:
1774:
1747:
1743:
1704:
1700:
1663:
1659:
1624:
1620:
1578:
1574:
1564:
1529:
1525:
1490:(1): 57–67.
1487:
1484:J. Mol. Biol
1483:
1477:
1450:
1446:
1436:
1409:
1405:
1378:
1345:
1341:
1335:
1326:
1317:
1308:
1299:
1214:
1211:Interactions
1186:
1173:
1165:
1164:
1086:NP_001334187
1082:NP_001103968
1079:
1058:
1047:NP_001276057
1043:NP_001276055
1039:NP_001276054
1015:NM_001347258
1007:NM_001110498
1004:
986:NM_001385055
982:NM_001385054
975:
968:NM_001289128
964:NM_001289126
960:NM_001289125
931:
912:
886:
867:
841:
822:
802:
797:
523:right kidney
427:
420:
147:External IDs
74:
15:
2797:(TNFRSF13C)
2789:(TNFRSF13B)
2781:(TNFRSF12A)
2773:(TNFRSF11B)
2765:(TNFRSF11A)
2757:(TNFRSF10D)
2749:(TNFRSF10C)
2741:(TNFRSF10B)
2733:(TNFRSF10A)
2337:PDB gallery
551:bone marrow
515:granulocyte
465:granulocyte
386:91,202,477
373:91,169,671
285:33,265,675
272:33,205,282
125:Identifiers
2872:(TNFRSF27)
2864:(TNFRSF25)
2856:(TNFRSF21)
2837:(TNFRSF19)
2829:(TNFRSF18)
2821:(TNFRSF17)
2813:(TNFRSF16)
2805:(TNFRSF14)
2690:(TNFRSF6B)
2650:(TNFRSF1B)
2642:(TNFRSF1A)
2277:J. Immunol
2242:J. Immunol
2072:J. Immunol
1993:J. Immunol
1851:Genome Res
1447:J. Immunol
1294:, May 2017
1273:, May 2017
1249:References
481:lymph node
431:(ortholog)
168:HomoloGene
3156:prolactin
2714:(TNFRSF9)
2706:(TNFRSF8)
2698:(TNFRSF7)
2682:(TNFRSF6)
2674:(TNFRSF5)
2666:(TNFRSF4)
2658:(TNFRSF3)
1370:140206806
1090:NP_034639
1061:NP_997468
1051:NP_997467
1035:NP_000865
1011:NM_010509
978:NM_207584
956:NM_000874
952:NM_207585
788:Orthologs
176:GeneCards
3417:Category
3385:TGF-beta
2886:JAK-STAT
2834:TAJ/TROY
2299:12218119
2264:12133952
2229:12105218
2194:11888273
2164:11786546
2129:11301323
2094:11046044
2059:10830953
2015:10395669
1980:10339405
1803:24680458
1643:15389589
1597:11786546
1504:10339405
1469:11046044
1428:11301323
1290:–
1269:–
1217:interact
1183:Function
1138:Wikidata
767:Sources:
692:membrane
457:monocyte
264:21q22.11
3381:Ser/Thr
3203:IL22RA2
3199:IL22RA1
3170:Type II
3099:IL12RB2
3095:IL12RB1
3078:IL12RB1
2977:β-chain
2946:IL13RA2
2942:IL13RA1
2904:γ-chain
2037:Bibcode
1951:9121453
1908:8969169
1873:8889548
1838:8798579
1795:7759950
1766:7665574
1731:7588638
1680:7570186
1651:4833543
1556:9121453
1362:8181059
1292:Ensembl
1271:Ensembl
1170:protein
900:UniProt
855:Ensembl
794:Species
773:QuickGO
473:pylorus
406:pattern
164:1098243
132:Aliases
3400:family
3395:TGFBR2
3390:TGFBR1
3344:IL17RE
3339:IL17RD
3334:IL17RC
3329:IL17RB
3324:IL17RA
3301:IL18R1
3254:IFNGR2
3250:IFNGR1
3241:IFNAR2
3237:IFNAR1
3216:IL20RB
3212:IL20RA
3191:IL10RB
3187:IL10RA
3121:other
3051:IL27RA
3042:IL11RA
3010:GM-CSF
2895:Type I
2778:TweakR
2610:CMKLR1
2588:CX3CR1
2297:
2262:
2227:
2192:
2162:
2127:
2092:
2057:
2029:Nature
2013:
1978:
1949:
1942:232052
1939:
1906:
1871:
1836:
1801:
1793:
1764:
1729:
1722:394613
1719:
1701:EMBO J
1688:972314
1686:
1678:
1649:
1641:
1595:
1554:
1547:232052
1544:
1502:
1467:
1426:
1368:
1360:
1238:, and
1224:GNB2L1
1219:with:
1174:IFNAR2
1124:search
1122:PubMed
933:O35664
914:P48551
810:Entrez
577:BioGPS
539:thymus
535:spleen
489:spleen
461:oocyte
180:IFNAR2
156:602376
139:IFNAR2
24:IFNAR2
3369:CSF1R
3297:IL18R
3290:IL1R2
3285:IL1R1
3221:IL28R
3208:IL20R
3195:IL22R
3183:IL10R
3133:G-CSF
3115:Other
3104:IL23R
3091:IL12R
3068:CNTFR
3033:IL6RA
3020:gp130
3003:IL5RA
2994:IL3RA
2965:IL21R
2955:IL7RA
2938:IL13R
2929:IL15R
2925:IL2RB
2921:IL2RA
2869:EDA2R
2846:21-27
2794:BAFFR
2723:11-20
2711:CD137
2663:CD134
2647:TNFR2
2639:TNFR1
2605:CCBP2
2584:CX3C
2578:Other
2569:CXCR7
2564:CXCR6
2559:CXCR5
2554:CXCR4
2549:CXCR3
2542:CXCR2
2537:CXCR1
2514:CCR10
2474:CCRL2
2464:CCRL1
2442:GPCRs
1799:S2CID
1684:S2CID
1647:S2CID
1366:S2CID
1242:STAT2
1236:STAT1
1230:IFNA2
1205:STAT2
1201:STAT1
1168:is a
843:15976
803:Mouse
798:Human
769:Amigo
453:blood
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
172:49242
3319:IL17
3233:-α/β
3063:LIFR
3058:OSMR
2999:IL5R
2990:IL3R
2960:IL9R
2951:IL7R
2934:IL4R
2917:IL2R
2826:GITR
2818:BCMA
2810:NGFR
2802:HVEM
2786:TACI
2762:RANK
2754:DcR2
2746:DcR1
2703:CD30
2695:CD27
2687:DcR3
2671:CD40
2655:LTBR
2632:1-10
2598:XCR1
2532:IL-8
2509:CCR9
2504:CCR8
2499:CCR7
2494:CCR6
2489:CCR5
2484:CCR4
2479:CCR3
2469:CCR2
2460:CCR1
2385:2hym
2370:1n6v
2355:1n6u
2295:PMID
2260:PMID
2225:PMID
2190:PMID
2160:PMID
2125:PMID
2090:PMID
2055:PMID
2011:PMID
1976:PMID
1947:PMID
1904:PMID
1869:PMID
1834:PMID
1791:PMID
1762:PMID
1727:PMID
1676:PMID
1639:PMID
1593:PMID
1552:PMID
1500:PMID
1465:PMID
1424:PMID
1358:PMID
1342:Cell
1203:and
1177:gene
824:3455
412:Bgee
360:Band
321:Chr.
259:Band
218:Chr.
152:OMIM
109:3SE4
105:3SE3
101:3S9D
97:3S8W
93:2LAG
89:2KZ1
85:2HYM
81:1N6V
77:1N6U
58:RCSB
55:PDBe
3374:KIT
3364:Tyr
3280:IL1
3128:EPO
2861:DR3
2853:DR6
2738:DR5
2730:DR4
2594:XC
2524:CXC
2285:doi
2281:169
2250:doi
2246:169
2215:doi
2211:277
2182:doi
2150:doi
2146:277
2115:doi
2111:276
2080:doi
2076:165
2045:doi
2033:405
2001:doi
1997:163
1968:doi
1964:289
1937:PMC
1929:doi
1894:doi
1890:271
1859:doi
1824:doi
1820:271
1783:doi
1752:doi
1748:270
1717:PMC
1709:doi
1668:doi
1629:doi
1625:202
1583:doi
1579:277
1542:PMC
1534:doi
1492:doi
1488:289
1455:doi
1451:165
1414:doi
1410:276
1350:doi
382:End
281:End
184:OMA
160:MGI
48:PDB
3419::
3383::
3299:/
3252:/
3246:-γ
3235:/
3214:/
3210:/
3201:/
3197:/
3193:/
3189:/
3185:/
3151:GH
3149::
3047:27
3038:11
3001:/
2992:/
2953:/
2944:/
2940:/
2936:/
2927:/
2919:/
2462:/
2452:CC
2293:.
2279:.
2275:.
2258:.
2244:.
2240:.
2223:.
2209:.
2205:.
2188:.
2178:41
2176:.
2158:.
2144:.
2140:.
2123:.
2109:.
2105:.
2088:.
2074:.
2070:.
2053:.
2043:.
2031:.
2027:.
2009:.
1995:.
1991:.
1974:.
1962:.
1945:.
1935:.
1925:17
1923:.
1919:.
1902:.
1888:.
1884:.
1867:.
1853:.
1849:.
1832:.
1818:.
1814:.
1797:.
1789:.
1779:57
1777:.
1760:.
1746:.
1742:.
1725:.
1715:.
1705:14
1703:.
1699:.
1682:.
1674:.
1664:21
1662:.
1645:.
1637:.
1623:.
1619:.
1591:.
1577:.
1573:.
1550:.
1540:.
1530:17
1528:.
1524:.
1512:^
1498:.
1486:.
1463:.
1449:.
1445:.
1422:.
1408:.
1404:.
1392:^
1364:.
1356:.
1346:77
1344:.
1325:.
1307:.
1278:^
1257:^
1179:.
771:/
388:bp
375:bp
287:bp
274:bp
182:;
178::
174:;
170::
166:;
162::
158:;
154::
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
3248:/
3239:/
3097:/
3093:/
3049:/
3040:/
2923:/
2444:)
2440:(
2421:e
2414:t
2407:v
2330:e
2323:t
2316:v
2301:.
2287::
2266:.
2252::
2231:.
2217::
2196:.
2184::
2166:.
2152::
2131:.
2117::
2096:.
2082::
2061:.
2047::
2039::
2017:.
2003::
1982:.
1970::
1953:.
1931::
1910:.
1896::
1875:.
1861::
1855:6
1840:.
1826::
1805:.
1785::
1768:.
1754::
1733:.
1711::
1690:.
1670::
1653:.
1631::
1599:.
1585::
1558:.
1536::
1506:.
1494::
1471:.
1457::
1430:.
1416::
1386:.
1372:.
1352::
1329:.
1311:.
1244:.
1232:,
1226:,
306:)
203:)
186::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
