1466:
IGFBP-3 levels to the presence, or risk, of various cancers, or to patient outcomes. but unequivocal conclusions have often been lacking. For example, high plasma IGFBP-3 levels were associated with a reduced prospective risk of colorectal cancer in women. but in a study including men and women, colon cancer risk was positively associated with plasma IGFBP-3, while there was no significant association for rectal cancer. A large systematic review concluded that circulating IGFBP-3 levels showed a modest association with increased risk for a number of cancers, but the results vary among sites.
242:
1162:), which is activated by both IGFs. IGFBP-3 also interacts with cell-surface proteins, affecting cell signaling from outside the cell or after internalization, and also enters the cell nucleus where it binds to nuclear hormone receptors and other ligands. High levels of IGFBP-3 within tumors are associated with increased cancer severity (or worse outcome) for some cancers, but decreased severity or better outcome for others. No cases of IGFBP3 gene deletion in humans have been reported, but mice lacking the gene show near-normal growth.
219:
116:
141:
500:
493:
248:
147:
1275:, at nucleotide-202 in the promoter region, is significantly associated with circulating IGFBP-3 levels, although the mechanism is unclear. In some studies circulating IGFBP-3 also appears to be nutritionally regulated, although this may not be seen at the mRNA level. IGFBP-3 has been identified in human lymph, nipple aspirate, milk, amniotic fluid, follicular fluid, seminal plasma, urine, peritoneal dialysate,
1264:(GH); for example, serum IGFBP-3 is increased in acromegaly and low in GH-deficient children. However, IGFBP-3 gene expression in human liver is GH-independent. Because it is stabilized in human serum by forming complexes with IGF-1 and ALS, which are both GH-dependent, serum IGFBP-3 also appears regulated by GH. Its production by some non-hepatic tissues may also be directly GH-regulated.
1600:
1390:. IGFBP-3 can also inhibit cell function by mechanisms that are independent of effects on IGF1R signaling, even in cells that entirely lack IGF1R. IGF (or IGF1R) independent effects are commonly studied using mutant forms of IGFBP-3 with decreased IGF binding affinity. Thus, IGFBP-3-induced apoptosis in differentiating
1414:
Contrasting with the typical growth-inhibitory effects of IGFBP-3, stimulation of cell proliferation by IGFBP-3 has also been observed. This can occur either by enhancing IGF-stimulated proliferation or in the absence of IGF-1. In endothelial cells and mammary epithelial cells, the stimulatory effect
1243:
are known to cleave IGFBP-3 at single linker-domain sites, and in the circulation of pregnant women, IGFBP-3 is entirely proteolyzed, yet still capable of carrying normal amounts of IGF-1 and IGF-2. Binding capacity appears to be retained after proteolysis because of a cooperative interaction between
1473:
from benign to metastatic disease although production of the protein does not cease completely. IGFBP-3 is still made (at a lower level) by prostate cancer cells and secreted into the surrounding environment. However, instead of the full length, functional protein, IGFBP-3 is found to be cleaved.
1146:
IGFBP-3 was first isolated, characterized, and quantitated in human plasma, in 1986. It has well-documented functions in the circulation, in the extracellular environment, and inside cells. It is the main IGF transport protein in the bloodstream, where it carries the growth factors predominantly in
1154:
For IGFs to reach the tissues from the bloodstream, the circulating complexes are believed to partly dissociate, possibly enhanced by limited proteolysis of IGFBP-3. The IGF-1/IGFBP-3 ratio has sometimes been used as an index of IGF bioavailability in the human circulation, but this ignores IGF-1
1465:
Since IGFBP-3 is abundant in the bloodstream of healthy adults (typically 2–4 mg/L), and is largely stabilized by its complex formation with IGFs and ALS, it is unlikely that tumor-derived IGFBP-3 has a large influence on circulating levels. There have been many studies linking circulating
1286:(TGFβ), tumor necrosis factor-α, vitamin D, retinoic acid, IGF-1, and stimuli such as chemotherapy that activate the tumor suppressor p53. Estrogen inhibits IGFBP-3 production, and its tissue levels are lower in estrogen receptor (ER)-positive breast cancers than in ER-negative cancers.
2141:
Scharf JG, Schmidt-Sandte W, Pahernik SA, Koebe HG, Hartmann H (October 1995). "Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit of the insulin-like growth factor ternary binding protein complex in primary cultures of human hepatocytes".
3657:
Miyake H, Pollak M, Gleave ME (June 2000). "Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models".
1155:
binding to other IGFBPs (so the ratio is affected by the concentrations of all six IGFBPs), and the fact that IGF-2, which is three times more abundant than IGF-1 in the bloodstream of adults, occupies the majority of binding sites on circulating IGFBP-3.
1306:
are also known to bind IGFBP-3. In the cell and tissue environment many other interactions have been described (see Table). Two unrelated cell-surface proteins have been designated as IGFBP-3 receptors: low density lipoprotein receptor-related protein 1
7689:
1252:
IGFBP-3 mRNA is expressed in all tissue examined, with kidney, stomach, placenta, uterus and liver showing highest expression in rat tissues. Rat liver IGFBP-3 mRNA is found in nonparenchymal cells including sinusoidal endothelium, but not in
1394:
precursor cells is seen equally with a non-IGF binding IGFBP-3 mutant, demonstrating that the mechanism does not involve IGF binding. IGF1R-independent growth inhibition by IGFBP-3 may involve the induction of pro-apoptotic proteins such as
3324:
Hanafusa T, Yumoto Y, Nouso K, Nakatsukasa H, Onishi T, Fujikawa T, et al. (February 2002). "Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma".
1323:
system have also been reported, and other cell-surface proteins such as proteoglycans also bind IGFBP-3. IGFBP-3 can enter cells by both clathrin-mediated and caveolin-mediated endocytosis. possibly involving the transferrin receptor.
1457:
may be associated with poor patient outcome. However, consistent with the dual inhibitory and stimulatory roles of IGFBP-3 seen in cell culture, there are other cancer types, such as breast cancer, pancreatic cancer, and clear cell
7694:
3360:
Chang YS, Wang L, Liu D, Mao L, Hong WK, Khuri FR, Lee HY (December 2002). "Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small cell lung cancer".
3536:
Giovannucci E, Pollak MN, Platz EA, Willett WC, Stampfer MJ, Majeed N, et al. (April 2000). "A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women".
2070:
Albiston AL, Herington AC (January 1992). "Tissue distribution and regulation of insulin-like growth factor (IGF)-binding protein-3 messenger ribonucleic acid (mRNA) in the rat: comparison with IGF-I mRNA expression".
1941:
Ehrenborg E, Larsson C, Stern I, Janson M, Powell DR, Luthman H (March 1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7".
3613:
Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M (April 2004). "Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis".
3979:
Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG (October 1992). "Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma".
1462:
in which high tissue IGFBP-3 expression has been linked to poor prognostic features or patient outcome. The mechanisms regulating these contrasting effects of IGFBP-3 in vivo are not well understood.
3458:
Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC (March 2008). "Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma".
3678:
Figueroa JA, De Raad S, Tadlock L, Speights VO, Rinehart JJ (April 1998). "Differential expression of insulin-like growth factor binding proteins in high versus low
Gleason score prostate cancer".
2106:
Chin E, Zhou J, Dai J, Baxter RC, Bondy CA (June 1994). "Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex".
4752:
3713:
Birnbaum RS, Ware JL, Plymate SR (June 1994). "Insulin-like growth factor-binding protein-3 expression and secretion by cultures of human prostate epithelial cells and stromal fibroblasts".
1759:
Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M, et al. (December 2012). "IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors".
2179:"Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: serum levels and hepatic messenger ribonucleic acid responses in humans"
3501:
Takahashi M, Papavero V, Yuhas J, Kort E, Kanayama HO, Kagawa S, et al. (April 2005). "Altered expression of members of the IGF-axis in clear cell renal cell carcinoma".
3388:
Yu H, Levesque MA, Khosravi MJ, Papanastasiou-Diamandi A, Clark GM, Diamandis EP (December 1998). "Insulin-like growth factor-binding protein-3 and breast cancer survival".
3054:"Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells"
3824:
Mochizuki S, Shimoda M, Shiomi T, Fujii Y, Okada Y (February 2004). "ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3".
2445:
Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR (August 1998). "Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3".
255:
154:
6667:
2259:
Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N (October 1995). "Induction of the growth inhibitor IGF-binding protein 3 by p53".
4745:
2719:"Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis"
7627:
4653:
4163:
Gui Y, Murphy LJ (August 2003). "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1".
2403:"Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma"
7283:
6431:
3566:"Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden"
3431:
Sheen-Chen SM, Zhang H, Huang CC, Tang RP (April 2009). "Insulin-like growth factor-binding protein-3 in breast cancer: analysis with tissue microarray".
6048:
4738:
4638:
4436:
4347:
3229:"Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity"
1099:
813:
2972:"The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene"
794:
6106:
77:
4057:"Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis"
2631:"Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization"
6968:
6658:
2799:
Chan SS, Schedlich LJ, Twigg SM, Baxter RC (April 2009). "Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3".
2315:"High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum"
6263:
2220:"Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators"
5248:
4931:
7646:
7596:
7567:
7514:
6001:
5868:
4386:
3147:"Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner"
1741:
3188:"Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth factor action"
1723:
7684:
7325:
7321:
7317:
7313:
4866:
4850:
3789:
Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM (November 2000). "ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3".
1474:
This decreases the affinity of IGF binding to IGFBP-3, making the growth factors more likely to bind the IGF1R and promote cell survival.
241:
5594:
5513:
5380:
5297:
4643:
3401:
7309:
4684:
3013:"A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis"
1021:
218:
6998:
6117:
5677:
5288:
4689:
1028:
3940:"Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding"
2582:"Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells"
4946:
4890:
4881:
4016:"IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments"
2031:"Activity of human pregnancy insulin-like growth factor binding protein-3: determination by reconstituting recombinant complexes"
1902:"Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity"
7520:
4704:
1710:
1689:
1400:
1283:
1217:
4116:"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3"
1204:
containing secondary IGF binding residues, a cysteine rich region (6 cysteine residues), an 18 residue basic motif that binds
1182:
followed by the 264-residue mature protein. IGFBP-3 shares with the other five high-affinity IGFBPs and a 3-domain structure:
7607:
7583:
6723:
6279:
6142:
4431:
4340:
1706:
1158:
Within tissues, IGFBP-3 can bind IGF-1 and IGF-2 released by many cell types, and block their access to the IGF-1 receptor (
1386:
cells, responsiveness to IGF-1 stimulation is suppressed by secreted IGFBP-3 and restored when IGFBP-3 is downregulated by
140:
115:
7573:
2531:"Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer"
1209:
1122:, sometimes included in this family, shares neither the conserved structural features nor the high IGF affinity. Instead,
1685:
7617:
6013:
5895:
5885:
4501:
3098:"Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling pathways"
1522:
1516:
57:
1294:
The main IGFBP-3 ligands in the circulation are IGF-1 and IGF-2, and the acid-labile subunit (ALS). The serum proteins
6963:
4546:
1483:
254:
153:
6988:
3859:
Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P (2003). "Type Ialpha collagen is an IGFBP-3 binding protein".
1607:
The 2014 version of this article was updated by an external expert under a dual publication model. The corresponding
2882:"The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents"
7602:
5428:
4714:
4515:
4368:
1454:
1396:
1355:, IGFBP-3 also interacts with DNA-dependent protein kinase within the nucleus to promote the repair of DNA damage.
247:
146:
6983:
1445:
Dysregulation of IGFBP-3 has been implicated in many cancers. Downregulation of its tissue expression by promoter
7510:
4613:
4333:
1542:
1501:
1232:. By electrophoretic analysis IGFBP-3 appears as a doublet, owing to the occupancy of either two or three of its
4245:
Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions".
2675:"Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit"
5694:
5610:
5529:
5396:
5313:
4505:
1511:
1332:
858:
65:
5128:
3896:"Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage"
2760:"Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells"
1411:
action IGFBP-3 interaction with nuclear hormone receptors may also lead to inhibition of cell proliferation.
7294:
5041:
4916:
4719:
4593:
4541:
4212:"Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions"
1432:
1420:
1387:
1327:
IGFBP-3 enters the cell nucleus by a mechanism that is incompletely understood, but involves its binding to
839:
6973:
7578:
7194:
7098:
6958:
6718:
6137:
5123:
4761:
4709:
1340:
1272:
1147:
stable complexes that contain the binding protein, either IGF-1 or IGF-2, and a third protein called the
7652:
5849:
5493:
5133:
4772:
4570:
3146:
1853:"Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma"
1608:
1311:), also known as alpha-2-macroglobulin receptor or type V TGFβ receptor and the transmembrane protein
7592:
6978:
5910:
5859:
4679:
4575:
4068:
3750:"ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3"
2268:
1580:
129:
6728:
4803:
2580:
Micutkova L, Hermann M, Offterdinger M, Hess MW, Matscheski A, Pircher H, et al. (April 2012).
44:
6733:
6147:
5844:
5036:
4391:
1552:
1336:
983:
928:
5769:
7351:
7264:
7209:
7163:
7108:
6843:
6783:
6411:
5784:
5714:
5273:
4871:
4813:
4764:
4630:
4313:
4270:
4188:
4145:
3639:
3483:
3413:
3306:
3127:
2611:
2511:
2292:
1809:"Insulin-like growth factor-binding protein from human plasma. Purification and characterization"
1784:
1416:
1344:
1320:
89:
7346:
7224:
7123:
6909:
6798:
6598:
6558:
6306:
6225:
6087:
6028:
5990:
5935:
5930:
5920:
5794:
5789:
5759:
5734:
5729:
5719:
5605:
5524:
5463:
5391:
5370:
5355:
5308:
4961:
2923:"EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I"
1178:
gene in tail-to-tail orientation, separated by 20 kb. The encoded protein includes a 27-residue
1004:
979:
953:
932:
7446:
7304:
7239:
7219:
7138:
7118:
6833:
6813:
6793:
6436:
5764:
5488:
5021:
4818:
1236:
sites by carbohydrate. Hypoglycosylated IGFBP-3 may be seen after extended glucose starvation.
499:
492:
7269:
7259:
7214:
7168:
7158:
7113:
7038:
6937:
6904:
6884:
6848:
6838:
6788:
6748:
6220:
6200:
6167:
5950:
5799:
4305:
4262:
4233:
4180:
4137:
4096:
4037:
3996:
3961:
3917:
3876:
3841:
3806:
3771:
3730:
3695:
3667:
3631:
3595:
3546:
3518:
3475:
3440:
3405:
3370:
3342:
3298:
3260:
3209:
3168:
3119:
3075:
3034:
2993:
2952:
2903:
2857:
2816:
2781:
2740:
2696:
2652:
2603:
2562:
2503:
2462:
2424:
2380:
2336:
2284:
2241:
2200:
2177:
Olivecrona H, Hilding A, Ekström C, Barle H, Nyberg B, Möller C, et al. (February 1999).
2159:
2123:
2088:
2052:
2011:
1959:
1923:
1882:
1830:
1776:
1653:
1459:
1364:
1201:
1187:
37:
7229:
7128:
7023:
6927:
6879:
6872:
6858:
6803:
6773:
6253:
6243:
6195:
6177:
5940:
5779:
5724:
3096:
Granata R, Trovato L, Garbarino G, Taliano M, Ponti R, Sala G, et al. (September 2004).
1599:
7456:
6588:
4648:
4295:
4254:
4223:
4172:
4127:
4086:
4076:
4027:
3988:
3951:
3907:
3868:
3833:
3798:
3761:
3722:
3687:
3623:
3585:
3577:
3510:
3467:
3397:
3334:
3290:
3250:
3240:
3199:
3158:
3109:
3065:
3024:
2983:
2942:
2934:
2921:
Takaoka M, Smith CE, Mashiba MK, Okawa T, Andl CD, El-Deiry WS, Nakagawa H (February 2006).
2893:
2847:
2808:
2771:
2730:
2686:
2642:
2593:
2552:
2542:
2529:
Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, et al. (September 2010).
2493:
2454:
2414:
2370:
2326:
2276:
2231:
2190:
2151:
2115:
2080:
2042:
2001:
1993:
1951:
1913:
1872:
1864:
1820:
1768:
1643:
1635:
1446:
1439:
334:
265:
209:
164:
85:
5980:
3281:
Baxter RC (May 2014). "IGF binding proteins in cancer: mechanistic and clinical insights".
1315:. Both are believed to mediate antiproliferative effects. Functional interactions with the
7068:
4497:
4422:
4360:
1470:
1233:
1225:
309:
4072:
3564:
Palmqvist R, Hallmans G, Rinaldi S, Biessy C, Stenling R, Riboli E, Kaaks R (May 2002).
3011:
Longobardi L, Torello M, Buckway C, O'Rear L, Horton WA, Hwa V, et al. (May 2003).
2272:
1170:
The IGFBP3 gene (or IBP3), on human chromosome 7, is organized into four protein-coding
7642:
7563:
7505:
7199:
7048:
7043:
6157:
6152:
4798:
4788:
4783:
4620:
4488:
3590:
3565:
3255:
3228:
2947:
2922:
2717:
Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM, Cohen P (October 2000).
2557:
2530:
2006:
1981:
1648:
1626:
1621:
1276:
1261:
1191:
1179:
4132:
4115:
4091:
4056:
3872:
3691:
3627:
3338:
2836:"Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3"
2331:
2314:
1918:
1901:
1877:
1852:
1825:
1808:
1268:
for serum IGFBP-3 are often used as part of the diagnosis of childhood GH-deficiency.
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
617:
612:
607:
602:
597:
592:
576:
571:
566:
561:
556:
551:
546:
541:
7678:
7336:
7249:
7178:
7148:
7083:
6993:
6947:
6823:
6753:
6698:
6687:
6172:
5880:
5563:
5468:
5360:
4694:
4558:
4520:
4483:
2155:
1955:
1221:
528:
4730:
4317:
4149:
4114:
Storch S, Kübler B, Höning S, Ackmann M, Zapf J, Blum W, Braulke T (December 2001).
3643:
3487:
3310:
3131:
2615:
2515:
2458:
1788:
1190:
containing a cysteine rich region (12 cysteine residues) with multiple intra-domain
7662:
7632:
7371:
7361:
7254:
7153:
7008:
6828:
6763:
6678:
6182:
5985:
5824:
5819:
5739:
5689:
5503:
5257:
5238:
5217:
5188:
4911:
4906:
4478:
4284:"Role of insulin-like growth factor binding protein-3 in breast cancer cell growth"
4274:
4192:
4055:
Ikonen M, Liu B, Hashimoto Y, Ma L, Lee KW, Niikura T, et al. (October 2003).
3417:
2834:
Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P (August 2007).
2480:
Huang SS, Ling TY, Tseng WF, Huang YH, Tang FM, Leal SM, Huang JS (November 2003).
2357:
Weinzimer SA, Gibson TB, Collett-Solberg PF, Khare A, Liu B, Cohen P (April 2001).
2296:
1562:
1316:
327:
106:
2758:
Ikezoe T, Tanosaki S, Krug U, Liu B, Cohen P, Taguchi H, Koeffler HP (July 2004).
1982:"Unraveling insulin-like growth factor binding protein-3 actions in human disease"
1244:
the two proteolyzed fragments, that together maintain an active IGF-binding site.
1197:
A highly variable central or linker domain (only 15% conservation between IGFBPs).
69:
3471:
2673:
Schedlich LJ, Le Page SL, Firth SM, Briggs LJ, Jans DA, Baxter RC (August 2000).
1110:) that have highly conserved structures and bind the insulin-like growth factors
93:
7622:
7588:
7486:
7476:
7471:
7461:
7411:
7234:
7133:
6894:
6808:
6738:
6633:
6396:
6361:
6311:
6274:
6210:
6092:
6023:
5975:
5965:
5960:
5955:
5839:
5834:
5829:
5207:
5118:
5108:
5076:
5071:
5066:
5061:
5051:
5011:
4976:
4658:
4510:
4426:
2359:"Transferrin is an insulin-like growth factor-binding protein-3 binding protein"
1746:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1728:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1547:
1506:
1391:
1303:
1299:
1295:
1265:
1229:
4061:
Proceedings of the
National Academy of Sciences of the United States of America
3837:
3204:
3187:
2812:
2776:
2759:
2119:
2084:
1639:
410:
7441:
7406:
7401:
7391:
7381:
7299:
7088:
7063:
7053:
6899:
6853:
6713:
6539:
6508:
6477:
6446:
6391:
6366:
6346:
6331:
6321:
6215:
6132:
5925:
5905:
5804:
5749:
5744:
5568:
5473:
5458:
5253:
5212:
5184:
5153:
5113:
5016:
4971:
4966:
4941:
4936:
4926:
4839:
4833:
4823:
4176:
3992:
1772:
1436:
1383:
1254:
226:
123:
73:
4325:
3163:
2988:
2971:
2938:
2218:
Deal C, Ma J, Wilkin F, Paquette J, Rozen F, Ge B, et al. (March 2001).
1174:
with a 5th exon in the 3' untranslated region. It is located adjacent to the
7466:
7436:
7431:
7426:
7421:
7416:
7396:
7386:
7376:
7366:
7058:
7018:
6914:
6889:
6648:
6643:
6638:
6628:
6623:
6618:
6608:
6529:
6467:
6401:
6381:
6376:
6371:
6356:
6351:
6341:
6336:
6230:
6205:
5970:
5890:
5809:
5754:
5644:
5583:
5573:
5478:
5365:
5163:
5158:
5148:
5056:
5046:
5031:
5006:
5001:
4991:
4986:
4981:
4699:
4663:
4081:
3956:
3939:
3938:
Buckway CK, Wilson EM, Ahlsén M, Bang P, Oh Y, Rosenfeld RG (October 2001).
3245:
2852:
2835:
2547:
1404:
1380:
758:
664:
positive regulation of insulin-like growth factor receptor signaling pathway
470:
348:
293:
280:
192:
179:
81:
7690:
Knowledge (XXG) articles with corresponding academic peer reviewed articles
4309:
4266:
4228:
4211:
4184:
4141:
4100:
4041:
3965:
3921:
3912:
3895:
3880:
3845:
3810:
3802:
3775:
3766:
3749:
3671:
3635:
3599:
3550:
3522:
3479:
3444:
3402:
10.1002/(sici)1097-0215(19981218)79:6<624::aid-ijc12>3.0.co;2-9
3374:
3346:
3302:
3264:
3123:
3079:
3070:
3053:
3038:
3029:
3012:
2956:
2907:
2861:
2820:
2785:
2744:
2735:
2718:
2700:
2691:
2674:
2656:
2647:
2630:
2607:
2566:
2507:
2428:
2419:
2402:
2384:
2375:
2358:
2245:
2236:
2219:
2204:
2195:
2178:
2056:
2015:
1780:
1657:
4237:
4000:
3734:
3726:
3699:
3409:
3213:
3172:
3114:
3097:
2997:
2498:
2481:
2466:
2340:
2288:
2163:
2127:
2092:
1963:
1927:
1886:
1834:
1068:
1063:
7637:
7356:
7013:
6613:
6603:
6583:
6518:
6487:
6456:
6420:
6326:
6316:
5663:
5143:
5086:
4996:
4956:
4032:
4015:
3581:
3514:
2898:
2881:
2047:
2030:
1997:
1557:
1450:
1408:
1348:
1328:
1240:
1052:
903:
884:
2629:
Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P (January 2004).
7612:
7033:
6498:
5900:
4861:
4356:
4300:
4283:
4014:
Grkovic S, O'Reilly VC, Han S, Hong M, Baxter RC, Firth SM (May 2013).
3894:
Martin JA, Miller BA, Scherb MB, Lembke LA, Buckwalter JA (July 2002).
1537:
1532:
1312:
1205:
1088:
870:
825:
7695:
Knowledge (XXG) articles with corresponding articles published in Gene
4258:
2598:
2581:
1868:
7525:
7189:
7078:
7003:
6708:
6703:
6127:
6122:
6076:
6072:
6068:
6064:
6056:
6052:
5704:
5243:
4921:
4471:
4466:
4461:
4456:
4446:
4441:
2970:
Valentinis B, Bhala A, DeAngelis T, Baserga R, Cohen P (March 1995).
2927:
American
Journal of Physiology. Gastrointestinal and Liver Physiology
2280:
1496:
1491:
1175:
1148:
1123:
1119:
1107:
1103:
1036:
780:
3294:
2482:"Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1"
1583:, Recombinant IGF-1 with IGFBP-3 used for a variety of indications.
654:
regulation of insulin-like growth factor receptor signaling pathway
7557:
7553:
7549:
7545:
7541:
7537:
7533:
7529:
7244:
7143:
6818:
6758:
6572:
6295:
6291:
6287:
6283:
5774:
5638:
5557:
5553:
5452:
5448:
5444:
5440:
5349:
5345:
5196:
4406:
4401:
4396:
4381:
4376:
1567:
1527:
1376:
1372:
1368:
1352:
1159:
1135:
1131:
1127:
1115:
1111:
1622:"Nuclear actions of insulin-like growth factor binding protein-3"
743:
739:
7028:
5634:
5630:
5626:
5622:
5618:
5614:
5549:
5545:
5541:
5537:
5533:
5436:
5432:
5424:
5420:
5416:
5412:
5408:
5404:
5400:
5341:
5337:
5333:
5329:
5325:
5321:
5317:
5269:
5265:
5261:
5227:
5192:
5173:
4608:
4603:
4598:
1308:
1171:
1095:
61:
4734:
4329:
508:
1593:
1423:, which promotes growth by transactivating the EGFR receptor.
1415:
of IGFBP-3 has been shown to involve activation of the enzyme
1282:
Many factors increase IGFBP-3 production by cells, including
1279:, tear fluid, and cerebrospinal fluid, in addition to serum.
1194:, an IGFBP motif (GCGCCXXC), the primary site of IGF binding.
2801:
American
Journal of Physiology. Endocrinology and Metabolism
1431:
Based on cell growth experiments, animal cancer models, and
1260:
IGFBP-3 levels in human serum are, like IGF-1, dependent on
3227:
Martin JL, Lin MZ, McGowan EM, Baxter RC (September 2009).
48:, BP-53, IBP3, insulin like growth factor binding protein 3
1469:
IGFBP-3 protein levels decrease during the progression of
3748:
Shi Z, Xu W, Loechel F, Wewer UM, Murphy LJ (June 2000).
3145:
Gill ZP, Perks CM, Newcomb PV, Holly JM (October 1997).
2880:
Lin MZ, Marzec KA, Martin JL, Baxter RC (January 2014).
317:
3052:
Butt AJ, Firth SM, King MA, Baxter RC (December 2000).
1379:(which stimulates cell proliferation). For example, in
639:
negative regulation of smooth muscle cell proliferation
7628:
Pituitary adenylate cyclase-activating peptide (PACAP)
2029:
Yan X, Payet LD, Baxter RC, Firth SM (November 2009).
1367:
effects in many cell types by blocking the ability of
1257:. In contrast, human hepatocytes do express IGFBP-3.
482:
3981:
The
Journal of Clinical Endocrinology and Metabolism
3944:
The
Journal of Clinical Endocrinology and Metabolism
2407:
The
Journal of Clinical Endocrinology and Metabolism
2363:
The
Journal of Clinical Endocrinology and Metabolism
2224:
The Journal of Clinical Endocrinology and Metabolism
2183:
The Journal of Clinical Endocrinology and Metabolism
1975:
1973:
709:
negative regulation of cell population proliferation
7495:
7282:
7177:
6946:
6686:
6677:
6657:
6571:
6548:
6517:
6486:
6455:
6419:
6410:
6262:
6105:
6038:
6000:
5867:
5858:
5676:
5653:
5593:
5512:
5379:
5296:
5287:
5226:
5172:
5085:
4889:
4880:
4849:
4771:
4672:
4629:
4586:
4529:
4415:
4367:
3826:
Biochemical and Biophysical Research Communications
3791:
Biochemical and Biophysical Research Communications
997:
972:
946:
921:
644:
negative regulation of smooth muscle cell migration
7574:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
6432:Glial cell line-derived neurotrophic factor (GDNF)
6085:Cleavage products/derivatives with unknown target:
1900:Cubbage ML, Suwanichkul A, Powell DR (July 1990).
1702:
1700:
1698:
1681:
1679:
1677:
603:insulin-like growth factor binding protein complex
729:regulation of phosphoprotein phosphatase activity
264:
163:
7608:Macrophage-stimulating protein (MSP; HLP, HGFLP)
4210:Rajaram S, Baylink DJ, Mohan S (December 1997).
3539:Cancer Epidemiology, Biomarkers & Prevention
5249:Heparin-binding EGF-like growth factor (HB-EGF)
4932:Heparin-binding EGF-like growth factor (HB-EGF)
3933:
3931:
3276:
3274:
3091:
3089:
2875:
2873:
2871:
2712:
2710:
2668:
2666:
2396:
2394:
2352:
2350:
1980:Jogie-Brahim S, Feldman D, Oh Y (August 2009).
669:positive regulation of myoblast differentiation
552:protein tyrosine phosphatase activator activity
16:Protein-coding gene in the species Homo sapiens
3186:Conover CA, Clarkson JT, Bale LK (June 1996).
2440:
2438:
2308:
2306:
1707:GRCm38: Ensembl release 89: ENSMUSG00000020427
634:negative regulation of protein phosphorylation
7660:Additional growth factor receptor modulators:
4746:
4341:
2313:Baxter RC, Martin JL, Beniac VA (July 1989).
1846:
1844:
1802:
1800:
1798:
1435:, it appears that IGFBP-3 functions as a low-
8:
6014:Insulin-like growth factor-2 (somatomedin A)
5896:Insulin-like growth factor-2 (somatomedin A)
5886:Insulin-like growth factor-1 (somatomedin C)
1081:Insulin-like growth factor-binding protein 3
1686:GRCh38: Ensembl release 89: ENSG00000146674
6683:
6416:
5864:
5293:
4886:
4753:
4739:
4731:
4437:Insulin-like growth factor binding protein
4348:
4334:
4326:
754:
694:negative regulation of signal transduction
593:insulin-like growth factor ternary complex
524:
305:
204:
101:
4299:
4227:
4131:
4090:
4080:
4031:
3955:
3911:
3765:
3589:
3254:
3244:
3203:
3162:
3113:
3069:
3028:
2987:
2946:
2897:
2851:
2775:
2734:
2690:
2646:
2597:
2556:
2546:
2497:
2418:
2374:
2330:
2235:
2194:
2046:
2005:
1917:
1876:
1824:
1647:
1419:, and generation of the bioactive lipid,
7618:Migration-stimulating factor (MSF; PRG4)
4282:Schedlich LJ, Graham LD (October 2002).
684:positive regulation of apoptotic process
4947:Transforming growth factor alpha (TGFα)
1673:
1208:, the acid labile subunit (ALS), and a
724:post-translational protein modification
659:regulation of glucose metabolic process
7521:Connective tissue growth factor (CTGF)
1851:Baxter RC, Martin JL (December 1986).
1403:and may be mediated by ceramides (pro-
1331:. Within the nucleus, it can modulate
1216:The linker domain is the site of most
18:
7584:Hepatoma-derived growth factor (HDGF)
1857:The Journal of Clinical Investigation
572:insulin-like growth factor II binding
269:
230:
225:
168:
127:
122:
7:
699:type B pancreatic cell proliferation
562:insulin-like growth factor I binding
4165:Molecular and Cellular Biochemistry
3754:The Journal of Biological Chemistry
3233:The Journal of Biological Chemistry
3151:The Journal of Biological Chemistry
3058:The Journal of Biological Chemistry
2723:The Journal of Biological Chemistry
2679:The Journal of Biological Chemistry
2635:The Journal of Biological Chemistry
2535:The Journal of Biological Chemistry
2319:The Journal of Biological Chemistry
1906:The Journal of Biological Chemistry
1813:The Journal of Biological Chemistry
704:positive regulation of MAPK cascade
2447:The American Journal of Physiology
1807:Martin JL, Baxter RC (July 1986).
1248:Sites and regulation of production
994:
969:
943:
918:
894:
875:
849:
830:
804:
785:
547:insulin-like growth factor binding
487:
405:
343:
322:
14:
4690:Cholesterylester transfer protein
4288:Microscopy Research and Technique
3861:Growth Hormone & IGF Research
3503:International Journal of Oncology
1138:binding, resulting in apoptosis.
1091:that in humans is encoded by the
7603:Leukemia inhibitory factor (LIF)
1598:
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
6771:Negative allosteric modulators:
4705:Latent TGF-beta binding protein
4654:Photosynthetic Reaction Centers
3390:International Journal of Cancer
2586:International Journal of Cancer
2459:10.1152/ajpendo.1998.275.2.E321
1620:Baxter RC (10 September 2015).
1478:Table: IGFBP-3 binding partners
1271:The most widely studied IGFBP3
1218:post-translational modification
719:regulation of apoptotic process
7089:Gossypetin (3,5,7,8,3',4'-HHF)
6280:Platelet-derived growth factor
4639:Plant Light-Harvesting Complex
4432:Growth hormone binding protein
1335:activity by direct binding to
509:More reference expression data
471:More reference expression data
1:
7295:Placental growth factor (PGF)
4133:10.1016/S0014-5793(01)03204-5
3873:10.1016/S1096-6374(03)00007-8
3692:10.1016/S0022-5347(01)63620-6
3628:10.1016/s0140-6736(04)16044-3
3339:10.1016/s0304-3835(01)00736-4
2401:Gui Y, Murphy LJ (May 2001).
2332:10.1016/S0021-9258(18)80143-0
1919:10.1016/S0021-9258(19)38392-9
1826:10.1016/S0021-9258(19)84446-0
1210:nuclear localization sequence
433:vestibular sensory epithelium
238:
137:
7579:Glia maturation factor (GMF)
6088:Glypromate (GPE, (1-3)IGF-1)
4502:Sex hormone binding globulin
3900:Osteoarthritis and Cartilage
3715:The Journal of Endocrinology
3472:10.1097/mpa.0b013e31815750f0
2156:10.1016/0168-8278(95)80201-0
1956:10.1016/0888-7543(92)90440-4
1284:transforming growth factor-β
7685:Genes on human chromosome 7
4547:Calmodulin-binding proteins
618:endoplasmic reticulum lumen
7711:
7511:Colony-stimulating factors
7503:Additional growth factors:
4715:Membrane transport protein
4516:Thyroxine-binding globulin
3838:10.1016/j.bbrc.2004.01.022
3205:10.1210/endo.137.6.8641177
2813:10.1152/ajpendo.90846.2008
2777:10.1182/blood-2003-07-2203
2120:10.1210/endo.134.6.7515002
2085:10.1210/endo.130.1.1370153
1640:10.1016/J.GENE.2015.06.028
1455:non-small cell lung cancer
1166:Gene and protein structure
679:osteoblast differentiation
6859:SNA-120 (pegylated K252a)
6031:(against IGF-1 and IGF-2)
5993:(against IGF-1 and IGF-2)
4644:Orange Carotenoid Protein
3993:10.1210/jcem.75.4.1383255
3676:For IGFBP-3 it refers to
1773:10.1126/scisignal.2003184
1742:"Mouse PubMed Reference:"
1724:"Human PubMed Reference:"
1611:article was published in
1482:IGFBP3 has been shown to
1449:in some cancers, such as
1067:
1062:
1058:
1051:
1035:
1016:
1001:
976:
965:
950:
925:
914:
901:
897:
882:
878:
869:
856:
852:
837:
833:
824:
811:
807:
792:
788:
779:
764:
757:
753:
737:
674:regulation of cell growth
527:
523:
506:
490:
481:
468:
417:
408:
375:mucosa of urinary bladder
371:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
5695:Hepatocyte growth factor
5254:Neuregulins (heregulins)
5185:Neuregulins (heregulins)
5129:Trastuzumab duocarmazine
4842:(against angiopoietin 2)
4836:(against angiopoietin 3)
4506:Androgen binding protein
3363:Clinical Cancer Research
3164:10.1074/jbc.272.41.25602
2989:10.1210/mend.9.3.7539889
2939:10.1152/ajpgi.00344.2005
1333:nuclear hormone receptor
1098:. IGFBP-3 is one of six
5042:Depatuxizumab mafodotin
4720:Odorant binding protein
4594:Retinol binding protein
4542:Calcium-binding protein
4177:10.1023/A:1024990409102
4082:10.1073/pnas.2135111100
3957:10.1210/jcem.86.10.7936
3246:10.1074/jbc.m109.007120
2976:Molecular Endocrinology
2548:10.1074/jbc.m110.122226
1433:epidemiological studies
1421:sphingosine-1-phosphate
1407:lipids), or potentiate
1388:epidermal growth factor
1319:and the type I/type II
1022:Chr 7: 45.91 – 45.92 Mb
649:protein phosphorylation
441:external carotid artery
7665:(neurotrophin mixture)
7653:Wnt signaling proteins
7334:Allosteric modulators:
7054:Norwogonin (5,7,8-THF)
5274:5 (tomoregulin, TMEFF)
5124:Trastuzumab deruxtecan
4762:Growth factor receptor
4710:Major urinary proteins
4229:10.1210/edrv.18.6.0321
3913:10.1053/joca.2002.0791
3803:10.1006/bbrc.2000.3835
3767:10.1074/jbc.M002172200
3680:The Journal of Urology
3283:Nature Reviews. Cancer
3071:10.1074/jbc.m908888199
3030:10.1210/en.2002-220959
2736:10.1074/jbc.m002547200
2692:10.1074/jbc.m002208200
2648:10.1074/jbc.m307316200
2420:10.1210/jcem.86.5.7472
2376:10.1210/jcem.86.4.7380
2237:10.1210/jcem.86.3.7280
2196:10.1210/JCEM.84.2.5466
1609:academic peer reviewed
1341:retinoic acid receptor
1029:Chr 11: 7.16 – 7.16 Mb
7593:T-cell growth factors
5850:Telisotuzumab vedotin
5134:Trastuzumab emtansine
4571:Iron-binding proteins
3727:10.1677/joe.0.1410535
3115:10.1096/fj.04-1618fje
2853:10.1093/carcin/bgm088
2499:10.1096/fj.03-0256com
2144:Journal of Hepatology
557:growth factor binding
363:palpebral conjunctiva
271:11 A1|11 4.75 cM
232:Chromosome 11 (mouse)
6178:EVT-901 (SAR-127963)
5911:Mecasermin rinfabate
4680:Acyl carrier protein
4576:Transferrin receptor
4033:10.1038/onc.2012.264
3582:10.1136/gut.50.5.642
3515:10.3892/ijo.26.4.923
2899:10.1038/onc.2012.538
2048:10.1210/en.2009-0090
1998:10.1210/er.2008-0028
1617:and can be cited as:
1581:Mecasermin rinfabate
1118:with high affinity.
1100:IGF binding proteins
689:regulation of growth
598:extracellular region
437:skin of external ear
130:Chromosome 7 (human)
4700:GTP-binding protein
4073:2003PNAS..10013042I
4067:(22): 13042–13047.
3760:(24): 18574–18580.
3622:(9418): 1346–1353.
3433:Anticancer Research
3239:(38): 25542–25552.
3157:(41): 25602–25607.
3064:(50): 39174–39181.
2729:(43): 33607–33613.
2685:(31): 23462–23470.
2541:(39): 30233–30246.
2325:(20): 11843–11848.
2273:1995Natur.377..646B
1912:(21): 12642–12649.
1337:retinoid X receptor
1149:acid-labile subunit
613:extracellular space
542:fibronectin binding
395:right lobe of liver
7344:Kinase inhibitors:
7207:Kinase inhibitors:
7106:Kinase inhibitors:
6781:Kinase inhibitors:
6596:Kinase inhibitors:
6556:Kinase inhibitors:
6537:Kinase inhibitors:
6506:Kinase inhibitors:
6475:Kinase inhibitors:
6444:Kinase inhibitors:
6304:Kinase inhibitors:
5918:Kinase inhibitors:
5712:Kinase inhibitors:
5501:Kinase inhibitors:
5494:Aprutumab ixadotin
5141:Kinase inhibitors:
4954:Kinase inhibitors:
4811:Kinase inhibitors:
4301:10.1002/jemt.10173
1417:sphingosine kinase
1345:vitamin D receptor
859:ENSMUSG00000020427
627:Biological process
586:Cellular component
535:Molecular function
94:IGFBP3 - orthologs
7672:
7671:
7278:
7277:
7039:N-Acetylserotonin
6938:ReN-1820 (TrkAd5)
6567:
6566:
6101:
6100:
6046:Binding proteins:
5705:Dihexa (PNB-0408)
5672:
5671:
5283:
5282:
5197:6 (neuroglycan C)
4917:EGF (urogastrone)
4895:
4728:
4727:
4259:10.1159/000023315
4216:Endocrine Reviews
4026:(19): 2412–2420.
3950:(10): 4943–4950.
3666:(11): 3058–3064.
3369:(12): 3669–3675.
3108:(12): 1456–1458.
2599:10.1002/ijc.26149
2492:(14): 2068–2081.
2267:(6550): 646–649.
2041:(11): 4968–4976.
1986:Endocrine Reviews
1869:10.1172/jci112742
1819:(19): 8754–8760.
1761:Science Signaling
1666:
1665:
1460:renal cell cancer
1365:antiproliferative
1202:C-terminal domain
1188:N-terminal domain
1078:
1077:
1074:
1073:
1047:
1046:
1012:
1011:
991:
990:
961:
960:
940:
939:
910:
909:
891:
890:
865:
864:
846:
845:
820:
819:
801:
800:
749:
748:
714:apoptotic process
567:metal ion binding
519:
518:
515:
514:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
7702:
7484:Decoy receptors:
7457:Alacizumab pegol
6935:Decoy receptors:
6684:
6589:Stem cell factor
6530:Persephin (PSPN)
6468:Neurturin (NRTN)
6417:
6254:LEVI-04 (p75-Fc)
6251:Decoy receptors:
5865:
5294:
4893:
4887:
4755:
4748:
4741:
4732:
4649:Phycobiliprotein
4361:carrier proteins
4350:
4343:
4336:
4327:
4321:
4303:
4278:
4247:Hormone Research
4241:
4231:
4197:
4196:
4171:(1–2): 189–195.
4160:
4154:
4153:
4135:
4111:
4105:
4104:
4094:
4084:
4052:
4046:
4045:
4035:
4011:
4005:
4004:
3987:(4): 1046–1053.
3976:
3970:
3969:
3959:
3935:
3926:
3925:
3915:
3891:
3885:
3884:
3856:
3850:
3849:
3821:
3815:
3814:
3786:
3780:
3779:
3769:
3745:
3739:
3738:
3710:
3704:
3703:
3686:(4): 1379–1383.
3675:
3654:
3648:
3647:
3610:
3604:
3603:
3593:
3561:
3555:
3554:
3533:
3527:
3526:
3498:
3492:
3491:
3455:
3449:
3448:
3439:(4): 1131–1135.
3428:
3422:
3421:
3385:
3379:
3378:
3357:
3351:
3350:
3321:
3315:
3314:
3278:
3269:
3268:
3258:
3248:
3224:
3218:
3217:
3207:
3198:(6): 2286–2292.
3183:
3177:
3176:
3166:
3142:
3136:
3135:
3117:
3093:
3084:
3083:
3073:
3049:
3043:
3042:
3032:
3023:(5): 1695–1702.
3008:
3002:
3001:
2991:
2967:
2961:
2960:
2950:
2933:(2): G404–G416.
2918:
2912:
2911:
2901:
2877:
2866:
2865:
2855:
2846:(8): 1653–1658.
2831:
2825:
2824:
2807:(4): E654–E663.
2796:
2790:
2789:
2779:
2755:
2749:
2748:
2738:
2714:
2705:
2704:
2694:
2670:
2661:
2660:
2650:
2626:
2620:
2619:
2601:
2592:(7): 1544–1557.
2577:
2571:
2570:
2560:
2550:
2526:
2520:
2519:
2501:
2477:
2471:
2470:
2453:(2): E321–E331.
2442:
2433:
2432:
2422:
2413:(5): 2104–2110.
2398:
2389:
2388:
2378:
2369:(4): 1806–1813.
2354:
2345:
2344:
2334:
2310:
2301:
2300:
2281:10.1038/377646a0
2256:
2250:
2249:
2239:
2230:(3): 1274–1280.
2215:
2209:
2208:
2198:
2174:
2168:
2167:
2138:
2132:
2131:
2114:(6): 2498–2504.
2103:
2097:
2096:
2067:
2061:
2060:
2050:
2026:
2020:
2019:
2009:
1977:
1968:
1967:
1938:
1932:
1931:
1921:
1897:
1891:
1890:
1880:
1863:(6): 1504–1512.
1848:
1839:
1838:
1828:
1804:
1793:
1792:
1756:
1750:
1749:
1738:
1732:
1731:
1720:
1714:
1704:
1693:
1683:
1661:
1651:
1602:
1594:
1447:hypermethylation
1440:tumor suppressor
1375:to activate the
1359:Cellular actions
1220:, which include
1083:, also known as
1060:
1059:
1031:
1024:
1007:
995:
986:
970:
966:RefSeq (protein)
956:
944:
935:
919:
895:
876:
850:
831:
805:
786:
755:
525:
511:
502:
495:
488:
473:
445:efferent ductule
413:
411:Top expressed in
406:
367:cartilage tissue
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
7710:
7709:
7705:
7704:
7703:
7701:
7700:
7699:
7675:
7674:
7673:
7668:
7613:Midkine (NEGF2)
7491:
7274:
7173:
6942:
6880:ABT-110 (PG110)
6673:
6653:
6563:
6544:
6513:
6482:
6451:
6406:
6258:
6196:ABT-110 (PG110)
6097:
6034:
5996:
5854:
5668:
5649:
5589:
5586:(against FGF23)
5508:
5375:
5279:
5222:
5168:
5081:
4892:
4876:
4845:
4767:
4759:
4729:
4724:
4685:Adaptor protein
4668:
4625:
4582:
4525:
4498:steroid hormone
4423:peptide hormone
4411:
4363:
4354:
4324:
4281:
4244:
4209:
4205:
4203:Further reading
4200:
4162:
4161:
4157:
4113:
4112:
4108:
4054:
4053:
4049:
4013:
4012:
4008:
3978:
3977:
3973:
3937:
3936:
3929:
3893:
3892:
3888:
3858:
3857:
3853:
3823:
3822:
3818:
3788:
3787:
3783:
3747:
3746:
3742:
3712:
3711:
3707:
3677:
3660:Cancer Research
3656:
3655:
3651:
3612:
3611:
3607:
3563:
3562:
3558:
3535:
3534:
3530:
3500:
3499:
3495:
3457:
3456:
3452:
3430:
3429:
3425:
3387:
3386:
3382:
3359:
3358:
3354:
3323:
3322:
3318:
3295:10.1038/nrc3720
3280:
3279:
3272:
3226:
3225:
3221:
3185:
3184:
3180:
3144:
3143:
3139:
3095:
3094:
3087:
3051:
3050:
3046:
3010:
3009:
3005:
2969:
2968:
2964:
2920:
2919:
2915:
2879:
2878:
2869:
2833:
2832:
2828:
2798:
2797:
2793:
2757:
2756:
2752:
2716:
2715:
2708:
2672:
2671:
2664:
2628:
2627:
2623:
2579:
2578:
2574:
2528:
2527:
2523:
2479:
2478:
2474:
2444:
2443:
2436:
2400:
2399:
2392:
2356:
2355:
2348:
2312:
2311:
2304:
2258:
2257:
2253:
2217:
2216:
2212:
2176:
2175:
2171:
2140:
2139:
2135:
2105:
2104:
2100:
2069:
2068:
2064:
2028:
2027:
2023:
1979:
1978:
1971:
1940:
1939:
1935:
1899:
1898:
1894:
1850:
1849:
1842:
1806:
1805:
1796:
1758:
1757:
1753:
1740:
1739:
1735:
1722:
1721:
1717:
1705:
1696:
1684:
1675:
1671:
1662:
1619:
1618:
1603:
1590:
1577:
1572:
1480:
1471:prostate cancer
1429:
1363:IGFBP-3 exerts
1361:
1292:
1250:
1234:N-glycosylation
1226:phosphorylation
1192:disulfide bonds
1168:
1144:
1130:, which blocks
1069:View/Edit Mouse
1064:View/Edit Human
1027:
1020:
1017:Location (UCSC)
1003:
982:
978:
952:
931:
927:
840:ENSG00000146674
733:
622:
581:
577:protein binding
507:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
7708:
7706:
7698:
7697:
7692:
7687:
7677:
7676:
7670:
7669:
7667:
7666:
7656:
7655:
7650:
7643:Thrombopoietin
7640:
7635:
7630:
7625:
7620:
7615:
7610:
7605:
7600:
7586:
7581:
7576:
7571:
7564:Erythropoietin
7561:
7523:
7518:
7508:
7506:Adrenomedullin
7499:
7497:
7493:
7492:
7490:
7489:
7480:
7479:
7474:
7469:
7464:
7459:
7450:
7449:
7444:
7439:
7434:
7429:
7424:
7419:
7414:
7409:
7404:
7399:
7394:
7389:
7384:
7379:
7374:
7369:
7364:
7359:
7354:
7349:
7340:
7339:
7330:
7329:
7307:
7302:
7297:
7288:
7286:
7280:
7279:
7276:
7275:
7273:
7272:
7267:
7262:
7257:
7252:
7247:
7242:
7237:
7232:
7227:
7222:
7217:
7212:
7203:
7202:
7197:
7192:
7183:
7181:
7175:
7174:
7172:
7171:
7166:
7161:
7156:
7151:
7146:
7141:
7136:
7131:
7126:
7121:
7116:
7111:
7102:
7101:
7092:
7091:
7086:
7081:
7072:
7071:
7066:
7061:
7056:
7051:
7046:
7041:
7036:
7031:
7026:
7021:
7016:
7011:
7006:
7001:
6996:
6991:
6986:
6981:
6976:
6971:
6969:4'-DMA-7,8-DHF
6966:
6961:
6952:
6950:
6944:
6943:
6941:
6940:
6931:
6930:
6918:
6917:
6912:
6907:
6902:
6897:
6892:
6887:
6882:
6863:
6862:
6856:
6851:
6846:
6841:
6836:
6831:
6826:
6821:
6816:
6811:
6806:
6801:
6796:
6791:
6786:
6777:
6776:
6767:
6766:
6761:
6756:
6751:
6742:
6741:
6736:
6731:
6729:Gambogic amide
6726:
6721:
6716:
6711:
6706:
6701:
6692:
6690:
6681:
6675:
6674:
6672:
6671:
6663:
6661:
6655:
6654:
6652:
6651:
6646:
6641:
6636:
6631:
6626:
6621:
6616:
6611:
6606:
6601:
6592:
6591:
6586:
6577:
6575:
6569:
6568:
6565:
6564:
6562:
6561:
6552:
6550:
6546:
6545:
6543:
6542:
6533:
6532:
6523:
6521:
6515:
6514:
6512:
6511:
6502:
6501:
6499:Artemin (ARTN)
6492:
6490:
6484:
6483:
6481:
6480:
6471:
6470:
6461:
6459:
6453:
6452:
6450:
6449:
6440:
6439:
6434:
6425:
6423:
6414:
6408:
6407:
6405:
6404:
6399:
6394:
6385:
6384:
6379:
6374:
6369:
6364:
6359:
6354:
6349:
6344:
6339:
6334:
6329:
6324:
6319:
6314:
6309:
6300:
6299:
6277:
6268:
6266:
6260:
6259:
6257:
6256:
6247:
6246:
6234:
6233:
6228:
6223:
6218:
6213:
6208:
6203:
6198:
6186:
6185:
6180:
6175:
6170:
6161:
6160:
6155:
6150:
6145:
6140:
6135:
6130:
6125:
6120:
6111:
6109:
6103:
6102:
6099:
6098:
6096:
6095:
6090:
6081:
6080:
6042:
6040:
6036:
6035:
6033:
6032:
6026:
6017:
6016:
6006:
6004:
5998:
5997:
5995:
5994:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5953:
5944:
5943:
5938:
5933:
5928:
5923:
5914:
5913:
5908:
5903:
5898:
5893:
5888:
5883:
5873:
5871:
5862:
5856:
5855:
5853:
5852:
5847:
5842:
5837:
5832:
5827:
5822:
5813:
5812:
5807:
5802:
5797:
5792:
5787:
5782:
5777:
5772:
5767:
5762:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5708:
5707:
5698:
5697:
5692:
5682:
5680:
5674:
5673:
5670:
5669:
5667:
5666:
5657:
5655:
5651:
5650:
5648:
5647:
5642:
5608:
5599:
5597:
5591:
5590:
5588:
5587:
5577:
5576:
5571:
5566:
5561:
5527:
5518:
5516:
5510:
5509:
5507:
5506:
5497:
5496:
5491:
5482:
5481:
5476:
5471:
5466:
5461:
5456:
5394:
5385:
5383:
5377:
5376:
5374:
5373:
5368:
5363:
5358:
5353:
5311:
5302:
5300:
5291:
5285:
5284:
5281:
5280:
5278:
5277:
5251:
5246:
5241:
5232:
5230:
5224:
5223:
5221:
5220:
5215:
5210:
5201:
5200:
5178:
5176:
5170:
5169:
5167:
5166:
5161:
5156:
5151:
5146:
5137:
5136:
5131:
5126:
5121:
5116:
5111:
5102:
5101:
5091:
5089:
5083:
5082:
5080:
5079:
5074:
5069:
5064:
5059:
5054:
5049:
5044:
5039:
5034:
5025:
5024:
5019:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4950:
4949:
4944:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4899:
4897:
4884:
4878:
4877:
4875:
4874:
4869:
4864:
4855:
4853:
4847:
4846:
4844:
4843:
4837:
4827:
4826:
4821:
4816:
4807:
4806:
4804:Angiopoietin 3
4801:
4799:Angiopoietin 2
4792:
4791:
4789:Angiopoietin 4
4786:
4784:Angiopoietin 1
4777:
4775:
4769:
4768:
4760:
4758:
4757:
4750:
4743:
4735:
4726:
4725:
4723:
4722:
4717:
4712:
4707:
4702:
4697:
4692:
4687:
4682:
4676:
4674:
4670:
4669:
4667:
4666:
4661:
4656:
4651:
4646:
4641:
4635:
4633:
4627:
4626:
4624:
4623:
4621:Transcobalamin
4618:
4617:
4616:
4611:
4606:
4601:
4590:
4588:
4584:
4583:
4581:
4580:
4579:
4578:
4573:
4563:
4562:
4561:
4551:
4550:
4549:
4544:
4533:
4531:
4527:
4526:
4524:
4523:
4518:
4513:
4508:
4494:
4493:
4492:
4491:
4486:
4476:
4475:
4474:
4469:
4464:
4459:
4454:
4449:
4444:
4434:
4429:
4419:
4417:
4413:
4412:
4410:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4373:
4371:
4365:
4364:
4355:
4353:
4352:
4345:
4338:
4330:
4323:
4322:
4279:
4242:
4222:(6): 801–831.
4206:
4204:
4201:
4199:
4198:
4155:
4126:(3): 395–398.
4106:
4047:
4006:
3971:
3927:
3906:(7): 556–563.
3886:
3867:(2–3): 89–97.
3851:
3816:
3797:(3): 511–515.
3781:
3740:
3721:(3): 535–540.
3705:
3649:
3605:
3576:(5): 642–646.
3556:
3545:(4): 345–349.
3528:
3509:(4): 923–931.
3493:
3466:(2): 160–167.
3450:
3423:
3396:(6): 624–628.
3380:
3352:
3333:(2): 149–158.
3327:Cancer Letters
3316:
3289:(5): 329–341.
3270:
3219:
3178:
3137:
3085:
3044:
3003:
2982:(3): 361–367.
2962:
2913:
2867:
2840:Carcinogenesis
2826:
2791:
2770:(1): 237–242.
2750:
2706:
2662:
2641:(1): 469–476.
2621:
2572:
2521:
2472:
2434:
2390:
2346:
2302:
2251:
2210:
2189:(2): 553–560.
2169:
2150:(4): 424–430.
2133:
2098:
2079:(1): 497–502.
2062:
2021:
1992:(5): 417–437.
1969:
1950:(3): 497–502.
1933:
1892:
1840:
1794:
1751:
1733:
1715:
1694:
1672:
1670:
1667:
1664:
1663:
1606:
1604:
1597:
1589:
1586:
1585:
1584:
1576:
1573:
1571:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1514:
1509:
1504:
1499:
1494:
1488:
1479:
1476:
1428:
1427:Role in cancer
1425:
1360:
1357:
1291:
1288:
1277:synovial fluid
1262:growth hormone
1249:
1246:
1228:, and limited
1214:
1213:
1198:
1195:
1180:signal peptide
1167:
1164:
1143:
1140:
1076:
1075:
1072:
1071:
1066:
1056:
1055:
1049:
1048:
1045:
1044:
1042:
1040:
1033:
1032:
1025:
1018:
1014:
1013:
1010:
1009:
999:
998:
992:
989:
988:
974:
973:
967:
963:
962:
959:
958:
948:
947:
941:
938:
937:
923:
922:
916:
912:
911:
908:
907:
899:
898:
892:
889:
888:
880:
879:
873:
867:
866:
863:
862:
854:
853:
847:
844:
843:
835:
834:
828:
822:
821:
818:
817:
809:
808:
802:
799:
798:
790:
789:
783:
777:
776:
771:
766:
762:
761:
751:
750:
747:
746:
735:
734:
732:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
630:
628:
624:
623:
621:
620:
615:
610:
605:
600:
595:
589:
587:
583:
582:
580:
579:
574:
569:
564:
559:
554:
549:
544:
538:
536:
532:
531:
521:
520:
517:
516:
513:
512:
504:
503:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
7707:
7696:
7693:
7691:
7688:
7686:
7683:
7682:
7680:
7664:
7661:
7658:
7657:
7654:
7651:
7648:
7644:
7641:
7639:
7636:
7634:
7631:
7629:
7626:
7624:
7621:
7619:
7616:
7614:
7611:
7609:
7606:
7604:
7601:
7598:
7594:
7590:
7587:
7585:
7582:
7580:
7577:
7575:
7572:
7569:
7565:
7562:
7559:
7555:
7551:
7547:
7543:
7539:
7535:
7531:
7527:
7524:
7522:
7519:
7516:
7512:
7509:
7507:
7504:
7501:
7500:
7498:
7494:
7488:
7485:
7482:
7481:
7478:
7475:
7473:
7470:
7468:
7465:
7463:
7460:
7458:
7455:
7452:
7451:
7448:
7445:
7443:
7440:
7438:
7435:
7433:
7430:
7428:
7425:
7423:
7420:
7418:
7415:
7413:
7410:
7408:
7405:
7403:
7400:
7398:
7395:
7393:
7390:
7388:
7385:
7383:
7380:
7378:
7375:
7373:
7370:
7368:
7365:
7363:
7360:
7358:
7355:
7353:
7350:
7348:
7345:
7342:
7341:
7338:
7337:Cyclotraxin B
7335:
7332:
7331:
7327:
7323:
7319:
7315:
7311:
7308:
7306:
7303:
7301:
7298:
7296:
7293:
7290:
7289:
7287:
7285:
7281:
7271:
7268:
7266:
7263:
7261:
7258:
7256:
7253:
7251:
7250:Larotrectinib
7248:
7246:
7243:
7241:
7238:
7236:
7233:
7231:
7228:
7226:
7223:
7221:
7218:
7216:
7213:
7211:
7208:
7205:
7204:
7201:
7198:
7196:
7193:
7191:
7188:
7185:
7184:
7182:
7180:
7176:
7170:
7167:
7165:
7162:
7160:
7157:
7155:
7152:
7150:
7149:Larotrectinib
7147:
7145:
7142:
7140:
7137:
7135:
7132:
7130:
7127:
7125:
7122:
7120:
7117:
7115:
7112:
7110:
7107:
7104:
7103:
7100:
7097:
7094:
7093:
7090:
7087:
7085:
7084:Cyclotraxin B
7082:
7080:
7077:
7074:
7073:
7070:
7067:
7065:
7062:
7060:
7057:
7055:
7052:
7050:
7047:
7045:
7042:
7040:
7037:
7035:
7032:
7030:
7027:
7025:
7022:
7020:
7017:
7015:
7012:
7010:
7007:
7005:
7002:
7000:
6997:
6995:
6994:Amitriptyline
6992:
6990:
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6970:
6967:
6965:
6962:
6960:
6957:
6954:
6953:
6951:
6949:
6945:
6939:
6936:
6933:
6932:
6929:
6926:
6923:
6920:
6919:
6916:
6913:
6911:
6908:
6906:
6903:
6901:
6898:
6896:
6893:
6891:
6888:
6886:
6883:
6881:
6878:
6874:
6871:
6870:Against TrkA:
6868:
6865:
6864:
6860:
6857:
6855:
6852:
6850:
6847:
6845:
6842:
6840:
6837:
6835:
6832:
6830:
6827:
6825:
6824:Larotrectinib
6822:
6820:
6817:
6815:
6812:
6810:
6807:
6805:
6802:
6800:
6797:
6795:
6792:
6790:
6787:
6785:
6782:
6779:
6778:
6775:
6772:
6769:
6768:
6765:
6762:
6760:
6757:
6755:
6754:Dexamethasone
6752:
6750:
6747:
6744:
6743:
6740:
6737:
6735:
6732:
6730:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6710:
6707:
6705:
6702:
6700:
6699:Amitriptyline
6697:
6694:
6693:
6691:
6689:
6685:
6682:
6680:
6676:
6669:
6665:
6664:
6662:
6660:
6656:
6650:
6647:
6645:
6642:
6640:
6637:
6635:
6632:
6630:
6627:
6625:
6622:
6620:
6617:
6615:
6612:
6610:
6607:
6605:
6602:
6600:
6597:
6594:
6593:
6590:
6587:
6585:
6582:
6579:
6578:
6576:
6574:
6570:
6560:
6557:
6554:
6553:
6551:
6547:
6541:
6538:
6535:
6534:
6531:
6528:
6525:
6524:
6522:
6520:
6516:
6510:
6507:
6504:
6503:
6500:
6497:
6494:
6493:
6491:
6489:
6485:
6479:
6476:
6473:
6472:
6469:
6466:
6463:
6462:
6460:
6458:
6454:
6448:
6445:
6442:
6441:
6438:
6435:
6433:
6430:
6427:
6426:
6424:
6422:
6418:
6415:
6413:
6409:
6403:
6400:
6398:
6395:
6393:
6390:
6387:
6386:
6383:
6380:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6360:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6313:
6310:
6308:
6305:
6302:
6301:
6297:
6293:
6289:
6285:
6281:
6278:
6276:
6273:
6270:
6269:
6267:
6265:
6261:
6255:
6252:
6249:
6248:
6245:
6242:
6239:
6236:
6235:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6191:
6188:
6187:
6184:
6181:
6179:
6176:
6174:
6173:Dexamethasone
6171:
6169:
6166:
6163:
6162:
6159:
6156:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6136:
6134:
6131:
6129:
6126:
6124:
6121:
6119:
6116:
6113:
6112:
6110:
6108:
6104:
6094:
6091:
6089:
6086:
6083:
6082:
6078:
6074:
6070:
6066:
6062:
6058:
6054:
6050:
6047:
6044:
6043:
6041:
6037:
6030:
6027:
6025:
6022:
6019:
6018:
6015:
6011:
6008:
6007:
6005:
6003:
5999:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5946:
5945:
5942:
5939:
5937:
5934:
5932:
5929:
5927:
5924:
5922:
5919:
5916:
5915:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5881:des(1-3)IGF-1
5878:
5875:
5874:
5872:
5870:
5866:
5863:
5861:
5857:
5851:
5848:
5846:
5845:Telisotuzumab
5843:
5841:
5838:
5836:
5833:
5831:
5828:
5826:
5823:
5821:
5818:
5815:
5814:
5811:
5808:
5806:
5803:
5801:
5798:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5778:
5776:
5773:
5771:
5768:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5710:
5709:
5706:
5703:
5702:Potentiators:
5700:
5699:
5696:
5693:
5691:
5687:
5684:
5683:
5681:
5679:
5675:
5665:
5662:
5659:
5658:
5656:
5652:
5646:
5643:
5640:
5636:
5632:
5628:
5624:
5620:
5616:
5612:
5609:
5607:
5604:
5601:
5600:
5598:
5596:
5592:
5585:
5582:
5579:
5578:
5575:
5572:
5570:
5567:
5565:
5564:Selpercatinib
5562:
5559:
5555:
5551:
5547:
5543:
5539:
5535:
5531:
5528:
5526:
5523:
5520:
5519:
5517:
5515:
5511:
5505:
5502:
5499:
5498:
5495:
5492:
5490:
5487:
5484:
5483:
5480:
5477:
5475:
5472:
5470:
5469:Selpercatinib
5467:
5465:
5462:
5460:
5457:
5454:
5450:
5446:
5442:
5438:
5434:
5430:
5426:
5422:
5418:
5414:
5410:
5406:
5402:
5398:
5395:
5393:
5390:
5387:
5386:
5384:
5382:
5378:
5372:
5369:
5367:
5364:
5362:
5361:Selpercatinib
5359:
5357:
5354:
5351:
5347:
5343:
5339:
5335:
5331:
5327:
5323:
5319:
5315:
5312:
5310:
5307:
5304:
5303:
5301:
5299:
5295:
5292:
5290:
5286:
5275:
5271:
5267:
5263:
5259:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5234:
5233:
5231:
5229:
5225:
5219:
5216:
5214:
5211:
5209:
5206:
5203:
5202:
5198:
5194:
5190:
5186:
5183:
5180:
5179:
5177:
5175:
5171:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5142:
5139:
5138:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5104:
5103:
5100:
5096:
5093:
5092:
5090:
5088:
5084:
5078:
5075:
5073:
5070:
5068:
5065:
5063:
5060:
5058:
5055:
5053:
5050:
5048:
5045:
5043:
5040:
5038:
5037:Depatuxizumab
5035:
5033:
5030:
5027:
5026:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4952:
4951:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4904:
4901:
4900:
4898:
4896:
4888:
4885:
4883:
4879:
4873:
4870:
4868:
4865:
4863:
4860:
4857:
4856:
4854:
4852:
4848:
4841:
4838:
4835:
4832:
4829:
4828:
4825:
4822:
4820:
4817:
4815:
4812:
4809:
4808:
4805:
4802:
4800:
4797:
4794:
4793:
4790:
4787:
4785:
4782:
4779:
4778:
4776:
4774:
4770:
4766:
4763:
4756:
4751:
4749:
4744:
4742:
4737:
4736:
4733:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4695:F-box protein
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4677:
4675:
4671:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4636:
4634:
4632:
4628:
4622:
4619:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4596:
4595:
4592:
4591:
4589:
4585:
4577:
4574:
4572:
4569:
4568:
4567:
4564:
4560:
4559:Ceruloplasmin
4557:
4556:
4555:
4552:
4548:
4545:
4543:
4540:
4539:
4538:
4535:
4534:
4532:
4530:Metal/element
4528:
4522:
4521:Transthyretin
4519:
4517:
4514:
4512:
4509:
4507:
4503:
4499:
4496:
4495:
4490:
4487:
4485:
4484:Neurophysin I
4482:
4481:
4480:
4477:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4439:
4438:
4435:
4433:
4430:
4428:
4424:
4421:
4420:
4418:
4414:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4375:
4374:
4372:
4370:
4366:
4362:
4358:
4351:
4346:
4344:
4339:
4337:
4332:
4331:
4328:
4319:
4315:
4311:
4307:
4302:
4297:
4293:
4289:
4285:
4280:
4276:
4272:
4268:
4264:
4260:
4256:
4252:
4248:
4243:
4239:
4235:
4230:
4225:
4221:
4217:
4213:
4208:
4207:
4202:
4194:
4190:
4186:
4182:
4178:
4174:
4170:
4166:
4159:
4156:
4151:
4147:
4143:
4139:
4134:
4129:
4125:
4121:
4117:
4110:
4107:
4102:
4098:
4093:
4088:
4083:
4078:
4074:
4070:
4066:
4062:
4058:
4051:
4048:
4043:
4039:
4034:
4029:
4025:
4021:
4017:
4010:
4007:
4002:
3998:
3994:
3990:
3986:
3982:
3975:
3972:
3967:
3963:
3958:
3953:
3949:
3945:
3941:
3934:
3932:
3928:
3923:
3919:
3914:
3909:
3905:
3901:
3897:
3890:
3887:
3882:
3878:
3874:
3870:
3866:
3862:
3855:
3852:
3847:
3843:
3839:
3835:
3831:
3827:
3820:
3817:
3812:
3808:
3804:
3800:
3796:
3792:
3785:
3782:
3777:
3773:
3768:
3763:
3759:
3755:
3751:
3744:
3741:
3736:
3732:
3728:
3724:
3720:
3716:
3709:
3706:
3701:
3697:
3693:
3689:
3685:
3681:
3673:
3669:
3665:
3661:
3653:
3650:
3645:
3641:
3637:
3633:
3629:
3625:
3621:
3617:
3609:
3606:
3601:
3597:
3592:
3587:
3583:
3579:
3575:
3571:
3567:
3560:
3557:
3552:
3548:
3544:
3540:
3532:
3529:
3524:
3520:
3516:
3512:
3508:
3504:
3497:
3494:
3489:
3485:
3481:
3477:
3473:
3469:
3465:
3461:
3454:
3451:
3446:
3442:
3438:
3434:
3427:
3424:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3391:
3384:
3381:
3376:
3372:
3368:
3364:
3356:
3353:
3348:
3344:
3340:
3336:
3332:
3328:
3320:
3317:
3312:
3308:
3304:
3300:
3296:
3292:
3288:
3284:
3277:
3275:
3271:
3266:
3262:
3257:
3252:
3247:
3242:
3238:
3234:
3230:
3223:
3220:
3215:
3211:
3206:
3201:
3197:
3193:
3192:Endocrinology
3189:
3182:
3179:
3174:
3170:
3165:
3160:
3156:
3152:
3148:
3141:
3138:
3133:
3129:
3125:
3121:
3116:
3111:
3107:
3103:
3102:FASEB Journal
3099:
3092:
3090:
3086:
3081:
3077:
3072:
3067:
3063:
3059:
3055:
3048:
3045:
3040:
3036:
3031:
3026:
3022:
3018:
3017:Endocrinology
3014:
3007:
3004:
2999:
2995:
2990:
2985:
2981:
2977:
2973:
2966:
2963:
2958:
2954:
2949:
2944:
2940:
2936:
2932:
2928:
2924:
2917:
2914:
2909:
2905:
2900:
2895:
2891:
2887:
2883:
2876:
2874:
2872:
2868:
2863:
2859:
2854:
2849:
2845:
2841:
2837:
2830:
2827:
2822:
2818:
2814:
2810:
2806:
2802:
2795:
2792:
2787:
2783:
2778:
2773:
2769:
2765:
2761:
2754:
2751:
2746:
2742:
2737:
2732:
2728:
2724:
2720:
2713:
2711:
2707:
2702:
2698:
2693:
2688:
2684:
2680:
2676:
2669:
2667:
2663:
2658:
2654:
2649:
2644:
2640:
2636:
2632:
2625:
2622:
2617:
2613:
2609:
2605:
2600:
2595:
2591:
2587:
2583:
2576:
2573:
2568:
2564:
2559:
2554:
2549:
2544:
2540:
2536:
2532:
2525:
2522:
2517:
2513:
2509:
2505:
2500:
2495:
2491:
2487:
2486:FASEB Journal
2483:
2476:
2473:
2468:
2464:
2460:
2456:
2452:
2448:
2441:
2439:
2435:
2430:
2426:
2421:
2416:
2412:
2408:
2404:
2397:
2395:
2391:
2386:
2382:
2377:
2372:
2368:
2364:
2360:
2353:
2351:
2347:
2342:
2338:
2333:
2328:
2324:
2320:
2316:
2309:
2307:
2303:
2298:
2294:
2290:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2255:
2252:
2247:
2243:
2238:
2233:
2229:
2225:
2221:
2214:
2211:
2206:
2202:
2197:
2192:
2188:
2184:
2180:
2173:
2170:
2165:
2161:
2157:
2153:
2149:
2145:
2137:
2134:
2129:
2125:
2121:
2117:
2113:
2109:
2108:Endocrinology
2102:
2099:
2094:
2090:
2086:
2082:
2078:
2074:
2073:Endocrinology
2066:
2063:
2058:
2054:
2049:
2044:
2040:
2036:
2035:Endocrinology
2032:
2025:
2022:
2017:
2013:
2008:
2003:
1999:
1995:
1991:
1987:
1983:
1976:
1974:
1970:
1965:
1961:
1957:
1953:
1949:
1945:
1937:
1934:
1929:
1925:
1920:
1915:
1911:
1907:
1903:
1896:
1893:
1888:
1884:
1879:
1874:
1870:
1866:
1862:
1858:
1854:
1847:
1845:
1841:
1836:
1832:
1827:
1822:
1818:
1814:
1810:
1803:
1801:
1799:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1767:(255): ra92.
1766:
1762:
1755:
1752:
1747:
1743:
1737:
1734:
1729:
1725:
1719:
1716:
1712:
1708:
1703:
1701:
1699:
1695:
1691:
1687:
1682:
1680:
1678:
1674:
1668:
1659:
1655:
1650:
1645:
1641:
1637:
1633:
1629:
1628:
1623:
1616:
1615:
1610:
1605:
1601:
1596:
1595:
1592:
1587:
1582:
1579:
1578:
1574:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1529:
1526:
1524:
1521:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1498:
1495:
1493:
1490:
1489:
1487:
1485:
1477:
1475:
1472:
1467:
1463:
1461:
1456:
1452:
1448:
1443:
1441:
1438:
1434:
1426:
1424:
1422:
1418:
1412:
1410:
1406:
1402:
1398:
1393:
1389:
1385:
1382:
1378:
1374:
1370:
1366:
1358:
1356:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1325:
1322:
1321:TGFβ receptor
1318:
1314:
1310:
1305:
1301:
1297:
1289:
1287:
1285:
1280:
1278:
1274:
1269:
1267:
1263:
1258:
1256:
1247:
1245:
1242:
1237:
1235:
1231:
1227:
1223:
1222:glycosylation
1219:
1211:
1207:
1203:
1199:
1196:
1193:
1189:
1185:
1184:
1183:
1181:
1177:
1173:
1165:
1163:
1161:
1156:
1152:
1150:
1141:
1139:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1109:
1105:
1101:
1097:
1094:
1090:
1086:
1082:
1070:
1065:
1061:
1057:
1054:
1050:
1043:
1041:
1038:
1034:
1030:
1026:
1023:
1019:
1015:
1008:
1006:
1000:
996:
993:
987:
985:
981:
975:
971:
968:
964:
957:
955:
949:
945:
942:
936:
934:
930:
924:
920:
917:
915:RefSeq (mRNA)
913:
906:
905:
900:
896:
893:
887:
886:
881:
877:
874:
872:
868:
861:
860:
855:
851:
848:
842:
841:
836:
832:
829:
827:
823:
816:
815:
810:
806:
803:
797:
796:
791:
787:
784:
782:
778:
775:
772:
770:
767:
763:
760:
756:
752:
745:
741:
736:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
631:
629:
626:
625:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
590:
588:
585:
584:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:Gonadal ridge
420:
419:
416:
412:
407:
404:
394:
390:
387:skin of thigh
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
7663:Cerebrolysin
7659:
7633:Pleiotrophin
7589:Interleukins
7502:
7483:
7453:
7372:Fruquintinib
7362:Cabozantinib
7343:
7333:
7291:
7255:Lestaurtinib
7206:
7186:
7154:Lestaurtinib
7105:
7095:
7076:Antagonists:
7075:
7009:Deoxygedunin
6964:3,7,8,2'-THF
6955:
6934:
6925:Against NGF:
6924:
6921:
6877:Against NGF:
6876:
6869:
6866:
6829:Lestaurtinib
6780:
6770:
6764:Testosterone
6746:Antagonists:
6745:
6695:
6595:
6580:
6555:
6536:
6526:
6505:
6495:
6474:
6464:
6443:
6428:
6388:
6303:
6271:
6250:
6241:Against NGF:
6240:
6237:
6193:Against NGF:
6192:
6189:
6183:Testosterone
6165:Antagonists:
6164:
6114:
6084:
6060:
6045:
6020:
6009:
5986:Teprotumumab
5947:
5917:
5876:
5825:Ficlatuzumab
5820:Emibetuzumab
5816:
5770:JNJ-38877605
5740:Cabozantinib
5711:
5701:
5690:Fosgonimeton
5685:
5660:
5602:
5580:
5521:
5504:Infigratinib
5500:
5485:
5388:
5305:
5239:Betacellulin
5235:
5218:Seribantumab
5204:
5181:
5140:
5105:
5099:Unknown/none
5098:
5094:
5028:
4953:
4912:Betacellulin
4907:Amphiregulin
4902:
4894:(ErbB1/HER1)
4858:
4830:
4810:
4796:Antagonists:
4795:
4780:
4773:Angiopoietin
4565:
4553:
4536:
4479:Neurophysins
4451:
4294:(1): 12–22.
4291:
4287:
4253:(2): 53–67.
4250:
4246:
4219:
4215:
4168:
4164:
4158:
4123:
4120:FEBS Letters
4119:
4109:
4064:
4060:
4050:
4023:
4019:
4009:
3984:
3980:
3974:
3947:
3943:
3903:
3899:
3889:
3864:
3860:
3854:
3832:(1): 79–84.
3829:
3825:
3819:
3794:
3790:
3784:
3757:
3753:
3743:
3718:
3714:
3708:
3683:
3679:
3663:
3659:
3652:
3619:
3615:
3608:
3573:
3569:
3559:
3542:
3538:
3531:
3506:
3502:
3496:
3463:
3459:
3453:
3436:
3432:
3426:
3393:
3389:
3383:
3366:
3362:
3355:
3330:
3326:
3319:
3286:
3282:
3236:
3232:
3222:
3195:
3191:
3181:
3154:
3150:
3140:
3105:
3101:
3061:
3057:
3047:
3020:
3016:
3006:
2979:
2975:
2965:
2930:
2926:
2916:
2892:(1): 85–96.
2889:
2885:
2843:
2839:
2829:
2804:
2800:
2794:
2767:
2763:
2753:
2726:
2722:
2682:
2678:
2638:
2634:
2624:
2589:
2585:
2575:
2538:
2534:
2524:
2489:
2485:
2475:
2450:
2446:
2410:
2406:
2366:
2362:
2322:
2318:
2264:
2260:
2254:
2227:
2223:
2213:
2186:
2182:
2172:
2147:
2143:
2136:
2111:
2107:
2101:
2076:
2072:
2065:
2038:
2034:
2024:
1989:
1985:
1947:
1943:
1936:
1909:
1905:
1895:
1860:
1856:
1816:
1812:
1764:
1760:
1754:
1745:
1736:
1727:
1718:
1631:
1625:
1613:
1612:
1591:
1481:
1468:
1464:
1444:
1430:
1413:
1362:
1326:
1317:EGF receptor
1293:
1290:Interactions
1281:
1273:polymorphism
1270:
1266:Immunoassays
1259:
1251:
1238:
1215:
1200:A conserved
1186:A conserved
1169:
1157:
1153:
1145:
1092:
1084:
1080:
1079:
1002:
984:NP_001013416
977:
951:
929:NM_001013398
926:
902:
883:
857:
838:
812:
793:
773:
768:
457:human kidney
449:right kidney
333:
326:
53:External IDs
7623:Oncomodulin
7487:Aflibercept
7477:Ranibizumab
7472:Ramucirumab
7462:Bevacizumab
7454:Antibodies:
7412:Regorafenib
7352:Altiratinib
7265:ONO-5390556
7235:Entrectinib
7210:Altiratinib
7164:ONO-5390556
7134:Entrectinib
7109:Altiratinib
6895:Frunevetmab
6867:Antibodies:
6844:ONO-5390556
6809:Entrectinib
6784:Altiratinib
6739:Tavilermide
6634:Quizartinib
6573:SCF (c-Kit)
6397:Ramucirumab
6389:Antibodies:
6362:Quizartinib
6312:Avapritinib
6275:Becaplermin
6211:Frunevetmab
6190:Antibodies:
6093:Trofinetide
6024:Dusigitumab
6021:Antibodies:
5976:Robatumumab
5966:Figitumumab
5961:Dalotuzumab
5956:Cixutumumab
5948:Antibodies:
5840:Rilotumumab
5835:Onartuzumab
5830:Flanvotumab
5817:Antibodies:
5785:PF-04217903
5715:Altiratinib
5678:HGF (c-Met)
5581:Antibodies:
5486:Antibodies:
5208:Duligotumab
5205:Antibodies:
5119:Trastuzumab
5109:Ertumaxomab
5106:Antibodies:
5077:Zalutumumab
5072:Panitumumab
5067:Nimotuzumab
5062:Necitumumab
5052:Imgatuzumab
5029:Antibodies:
5012:Osimertinib
4977:Dacomitinib
4872:Dapiclermin
4831:Antibodies:
4814:Altiratinib
4659:Phytochrome
4511:Transcortin
4427:Follistatin
1634:(1): 7–13.
1392:chondrocyte
1304:plasminogen
1300:fibronectin
1296:transferrin
1255:hepatocytes
1230:proteolysis
391:skin of hip
383:pericardium
191:45,921,874
178:45,912,245
31:Identifiers
7679:Categories
7442:Vandetanib
7407:Rebastinib
7402:Pegaptanib
7392:Nintedanib
7382:Lenvatinib
7347:Agerafenib
7300:Ripretinib
7225:CH-7057288
7124:CH-7057288
6989:7,8,3'-THF
6984:7,8,2'-THF
6910:Ranevetmab
6900:Fulranumab
6854:Rebastinib
6799:CH-7057288
6714:Cenegermin
6599:Agerafenib
6559:Agerafenib
6540:Vandetanib
6509:Vandetanib
6478:Vandetanib
6447:Vandetanib
6392:Olaratumab
6367:Ripretinib
6347:Nintedanib
6332:Lenvatinib
6322:Crenolanib
6307:Agerafenib
6226:Ranevetmab
6216:Fulranumab
6133:Cenegermin
6107:LNGF (p75)
6029:Xentuzumab
5991:Xentuzumab
5936:NVP-AEW541
5931:NVP-ADW742
5926:Linsitinib
5921:BMS-754807
5906:Mecasermin
5805:Tivantinib
5795:PHA-665752
5790:PF-2341066
5760:Golvatinib
5750:Crizotinib
5745:Capmatinib
5735:BMS-777607
5730:Amuvatinib
5606:Ersofermin
5569:Sprifermin
5525:Ersofermin
5474:Sprifermin
5464:Repifermin
5459:Palifermin
5392:Ersofermin
5371:Velafermin
5356:Repifermin
5309:Ersofermin
5228:ErbB4/HER4
5213:Patritumab
5174:ErbB3/HER3
5154:Mubritinib
5114:Pertuzumab
5087:ErbB2/HER2
5017:Vandetanib
4972:Canertinib
4967:Brigatinib
4962:Agerafenib
4942:Nepidermin
4937:Murodermin
4927:Epiregulin
4882:EGF (ErbB)
4840:Nesvacumab
4834:Evinacumab
4824:Rebastinib
4765:modulators
4369:Fatty acid
1713:, May 2017
1692:, May 2017
1669:References
1437:penetrance
1384:epithelial
1381:esophageal
1329:importin-β
337:(ortholog)
292:7,163,923
279:7,156,086
74:HomoloGene
7467:Icrucumab
7447:WHI-P 154
7437:Tivozanib
7432:Toceranib
7427:Sunitinib
7422:Sorafenib
7417:Semaxanib
7397:Pazopanib
7387:Motesanib
7377:Lapatinib
7367:Cediranib
7305:Telbermin
7292:Agonists:
7240:GZ-389988
7220:CE-245677
7187:Agonists:
7139:GZ-389988
7119:CE-245677
7019:Diosmetin
6956:Agonists:
6922:Aptamers:
6915:Tanezumab
6890:Fasinumab
6834:Milciclib
6814:GZ-389988
6794:CE-245677
6696:Agonists:
6649:Toceranib
6644:Sunitinib
6639:Sorafenib
6629:Pazopanib
6624:Nilotinib
6619:Masitinib
6609:Dasatinib
6581:Agonists:
6527:Agonists:
6496:Agonists:
6465:Agonists:
6437:Liatermin
6429:Agonists:
6412:RET (GFL)
6402:Tovetumab
6382:Toceranib
6377:Sorafenib
6372:Sunitinib
6357:Radotinib
6352:Pazopanib
6342:Motesanib
6337:Masitinib
6272:Agonists:
6238:Aptamers:
6231:Tanezumab
6206:Fasinumab
6115:Agonists:
5971:Ganitumab
5891:IGF-1 LR3
5810:Volitinib
5765:INCB28060
5755:Foretinib
5661:Agonists:
5645:Trafermin
5603:Agonists:
5584:Burosumab
5574:Trafermin
5522:Agonists:
5489:Aprutumab
5479:Trafermin
5441:10 (KGF2)
5389:Agonists:
5366:Trafermin
5346:10 (KGF2)
5306:Agonists:
5236:Agonists:
5182:Agonists:
5164:Tucatinib
5159:Neratinib
5149:Lapatinib
5057:Matuzumab
5047:Futuximab
5032:Cetuximab
5022:WHI-P 154
5007:Neratinib
5002:Lapatinib
4992:Grandinin
4987:Gefitinib
4982:Erlotinib
4859:Agonists:
4819:CE-245677
4781:Agonists:
4664:Rhodopsin
1405:apoptotic
1241:proteases
1005:NP_032369
980:NP_000589
954:NM_008343
933:NM_000598
759:Orthologs
82:GeneCards
7649:instead)
7638:Renalase
7599:instead)
7570:instead)
7517:instead)
7357:Axitinib
7326:D (FIGF)
7270:PLX-7486
7260:ONO-4474
7215:AZD-6918
7169:PLX-7486
7159:ONO-4474
7114:AZD-6918
7096:Ligands:
7014:Deprenyl
6974:7,3'-DHF
6905:MEDI-578
6885:ASP-6294
6849:PLX-7486
6839:ONO-4474
6789:AZD-6918
6749:ALE-0540
6670:instead.
6614:Imatinib
6604:Axitinib
6584:Ancestim
6549:Unsorted
6327:Imatinib
6317:Axitinib
6221:MEDI-578
6201:ASP-6294
6168:ALE-0540
6010:Agonists
5951:AVE-1642
5877:Agonists
5800:SU-11274
5686:Agonists
5664:FGF15/19
5654:Unsorted
5619:2 (bFGF)
5538:2 (bFGF)
5405:2 (bFGF)
5322:2 (bFGF)
5144:Afatinib
5095:Agonists
4997:Icotinib
4957:Afatinib
4903:Agonists
4357:Proteins
4318:25082403
4310:12242693
4267:10352394
4185:12962157
4150:22895295
4142:11749962
4101:14561895
4042:22751133
4020:Oncogene
3966:11600567
3922:12127836
3881:12735930
3846:15013428
3811:11095942
3776:10849447
3672:10850457
3644:25549626
3636:15110491
3600:11950809
3551:10794477
3523:15753986
3488:27663623
3480:18376307
3460:Pancreas
3445:19414355
3375:12473575
3347:11804742
3311:11169818
3303:24722429
3265:19633297
3132:13892154
3124:15247143
3080:10998426
3039:12697673
2957:16210470
2908:23178489
2886:Oncogene
2862:17434920
2821:19141684
2786:15026318
2745:10874028
2701:10811646
2657:14576164
2616:18570671
2608:21520041
2567:20353938
2516:84528390
2508:14597676
2429:11344214
2385:11297622
2246:11238520
2205:10022415
2057:19734278
2016:19477944
1944:Genomics
1789:24794913
1781:23250396
1709:–
1688:–
1658:26074086
1575:See also
1484:interact
1451:hepatoma
1409:ceramide
1151:or ALS.
1142:Function
1053:Wikidata
738:Sources:
425:gastrula
7526:Ephrins
7230:DS-6051
7129:DS-6051
7034:LM22A-4
7024:DMAQ-B1
6979:7,8-DHF
6959:3,7-DHF
6928:RBM-004
6873:GBR-900
6804:DS-6051
6774:VM-902A
6244:RBM-004
5941:OSl-906
5901:Insulin
5780:MK-2461
5725:AMG-458
4862:Axokine
4631:Pigment
4587:Vitamin
4537:calcium
4416:Hormone
4275:2710234
4238:9408744
4193:6372795
4069:Bibcode
4001:1383255
3735:7520932
3700:9507888
3591:1773192
3418:5683010
3410:9842972
3256:2757955
3214:8641177
3173:9325280
2998:7539889
2948:2996094
2558:2943278
2467:9688635
2341:2473065
2297:4317117
2289:7566179
2269:Bibcode
2164:8655960
2128:7515002
2093:1370153
2007:2819737
1964:1373120
1928:1695633
1887:2431001
1835:3722172
1711:Ensembl
1690:Ensembl
1649:4496269
1533:Humanin
1313:TMEM219
1206:heparin
1124:IGFBP-7
1120:IGFBP-7
1108:IGFBP-6
1104:IGFBP-1
1089:protein
1087:, is a
1085:IGFBP-3
871:UniProt
826:Ensembl
765:Species
744:QuickGO
608:nucleus
359:decidua
312:pattern
38:Aliases
7496:Others
7190:BNN-20
7079:ANA-12
7004:BNN-20
6724:DHEA-S
6709:BNN-27
6704:BNN-20
6143:DHEA-S
6128:BNN-27
6123:BNN-20
6039:Others
5244:Epigen
4922:Epigen
4554:copper
4472:IGFBP7
4467:IGFBP6
4462:IGFBP5
4457:IGFBP4
4452:IGFBP3
4447:IGFBP2
4442:IGFBP1
4316:
4308:
4273:
4265:
4236:
4191:
4183:
4148:
4140:
4099:
4092:240741
4089:
4040:
3999:
3964:
3920:
3879:
3844:
3809:
3774:
3733:
3698:
3670:
3642:
3634:
3616:Lancet
3598:
3588:
3549:
3521:
3486:
3478:
3443:
3416:
3408:
3373:
3345:
3309:
3301:
3263:
3253:
3212:
3171:
3130:
3122:
3078:
3037:
2996:
2955:
2945:
2906:
2860:
2819:
2784:
2743:
2699:
2655:
2614:
2606:
2565:
2555:
2514:
2506:
2465:
2427:
2383:
2339:
2295:
2287:
2261:Nature
2244:
2203:
2162:
2126:
2091:
2055:
2014:
2004:
1962:
1926:
1885:
1878:423906
1875:
1833:
1787:
1779:
1656:
1646:
1512:IGFALS
1502:COL1A1
1497:ADAM28
1492:ADAM12
1486:with:
1442:gene.
1351:, and
1302:, and
1176:IGFBP1
1126:binds
1093:IGFBP3
1039:search
1037:PubMed
904:P47878
885:P17936
781:Entrez
483:BioGPS
170:7p12.3
86:IGFBP3
62:146732
45:IGFBP3
22:IGFBP3
7645:(see
7595:(see
7566:(see
7513:(see
7245:K252a
7144:K252a
6819:K252a
6759:FX007
6519:GFRα4
6488:GFRα3
6457:GFRα2
6421:GFRα1
6049:IGFBP
6002:IGF-2
5981:R1507
5869:IGF-1
5775:K252a
5595:FGFR4
5514:FGFR3
5381:FGFR2
5298:FGFR1
4673:Other
4407:FABP7
4402:FABP6
4397:FABP5
4392:FABP4
4387:FABP3
4382:FABP2
4377:FABP1
4314:S2CID
4271:S2CID
4189:S2CID
4146:S2CID
3640:S2CID
3484:S2CID
3414:S2CID
3307:S2CID
3128:S2CID
2764:Blood
2612:S2CID
2512:S2CID
2293:S2CID
1785:S2CID
1614:Gene
1588:Notes
1568:LTBP1
1558:PRKDC
1553:KPNB1
1528:HSPA5
1377:IGF1R
1373:IGF-2
1369:IGF-1
1353:nur77
1349:PPARγ
1239:Many
1172:exons
1160:IGF1R
1136:IGF-2
1132:IGF-1
1128:IGF1R
1116:IGF-2
1112:IGF-1
814:16009
774:Mouse
769:Human
740:Amigo
429:molar
379:vulva
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
70:96438
7647:here
7597:here
7568:here
7515:here
7310:VEGF
7284:VEGF
7200:NT-3
7195:DHEA
7179:TrkC
7099:DHEA
7069:TDP6
7049:NT-4
7044:NT-3
7029:HIOC
6999:BDNF
6948:TrkB
6719:DHEA
6688:TrkA
6668:here
6666:See
6659:TGFβ
6264:PDGF
6158:NT-4
6153:NT-3
6138:DHEA
6118:BDNF
4867:CNTF
4851:CNTF
4566:iron
4306:PMID
4263:PMID
4234:PMID
4181:PMID
4138:PMID
4097:PMID
4038:PMID
3997:PMID
3962:PMID
3918:PMID
3877:PMID
3842:PMID
3807:PMID
3772:PMID
3731:PMID
3696:PMID
3668:PMID
3632:PMID
3596:PMID
3547:PMID
3519:PMID
3476:PMID
3441:PMID
3406:PMID
3371:PMID
3343:PMID
3299:PMID
3261:PMID
3210:PMID
3169:PMID
3120:PMID
3076:PMID
3035:PMID
2994:PMID
2953:PMID
2904:PMID
2858:PMID
2817:PMID
2782:PMID
2741:PMID
2697:PMID
2653:PMID
2604:PMID
2563:PMID
2504:PMID
2463:PMID
2425:PMID
2381:PMID
2337:PMID
2285:PMID
2242:PMID
2201:PMID
2160:PMID
2124:PMID
2089:PMID
2053:PMID
2012:PMID
1960:PMID
1924:PMID
1883:PMID
1831:PMID
1777:PMID
1654:PMID
1627:Gene
1563:EGFR
1543:RXRA
1523:IGF2
1517:IGF1
1453:and
1399:and
1371:and
1309:LRP1
1134:and
1114:and
1096:gene
795:3486
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
7064:R13
6734:NGF
6679:Trk
6148:NGF
5860:IGF
5720:AM7
5611:FGF
5530:FGF
5431:),
5429:KGF
5397:FGF
5314:FGF
5289:FGF
4891:EGF
4296:doi
4255:doi
4224:doi
4173:doi
4169:250
4128:doi
4124:509
4087:PMC
4077:doi
4065:100
4028:doi
3989:doi
3952:doi
3908:doi
3869:doi
3834:doi
3830:315
3799:doi
3795:278
3762:doi
3758:275
3723:doi
3719:141
3688:doi
3684:159
3624:doi
3620:363
3586:PMC
3578:doi
3570:Gut
3511:doi
3468:doi
3398:doi
3335:doi
3331:176
3291:doi
3251:PMC
3241:doi
3237:284
3200:doi
3196:137
3159:doi
3155:272
3110:doi
3066:doi
3062:275
3025:doi
3021:144
2984:doi
2943:PMC
2935:doi
2931:290
2894:doi
2848:doi
2809:doi
2805:296
2772:doi
2768:104
2731:doi
2727:275
2687:doi
2683:275
2643:doi
2639:279
2594:doi
2590:130
2553:PMC
2543:doi
2539:285
2494:doi
2455:doi
2451:275
2415:doi
2371:doi
2327:doi
2323:264
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2265:377
2232:doi
2191:doi
2152:doi
2116:doi
2112:134
2081:doi
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2002:PMC
1994:doi
1952:doi
1914:doi
1910:265
1873:PMC
1865:doi
1821:doi
1817:261
1769:doi
1644:PMC
1636:doi
1632:569
1538:PLG
1507:FN1
1401:Bad
1397:Bax
1106:to
453:lip
288:End
187:End
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