97:
122:
128:
749:
allergy will react quickly β within a few minutes to a few hours. Immediate reactions are caused by an allergen-specific immunoglobulin E (IgE) antibody that floats around in the blood stream. Another useful tool in diagnosing and managing food allergies is blood testing, called allergen-specific IgE testing. This test measures the level of antibody produced in the blood in response to a food allergen.
669:
1655:
748:
IgE-mediated food allergies is when the immune system reacts abnormally when exposed to one or more specific foods such as milk, egg, wheat or nuts. All of these foods can trigger anaphylaxis (a severe, whole-body allergic reaction) in patients who are allergic. Individuals with this type of food
744:
Each type of IgE has specific "radar" for each type of allergen. That's why some people are only allergic to cat dander (they only have the IgE antibodies specific to cat dander); while others have allergic reactions to multiple allergens because they have many more types of IgE antibodies.
736:
Immunoglobulins also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens, such as bacteria or viruses, and aiding in their destruction.
684:
14 for humans) has been predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and
705:: The gene that encodes the Ξ΅ heavy chain constant region for the IgE antibody. This gene is critical for the production and function of IgE in the body. The IGHE gene provides instructions for making a part of an antibody (
939:
915:
891:
1301:
Flanagan JG, Lefranc MP, Rabbitts TH (March 1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences".
1541:
Hajoui O, Janani R, Tulic M, Joubert P, Ronis T, Hamid Q, et al. (September 2004). "Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production".
135:
385:
689:. IGHE has also been predicted to be located in extracellular region, a part of immunoglobulin complex, circulating, and active in external side of
1696:
1715:
787:
987:
Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (August 1991). "The B-cell antigen receptor of the five immunoglobulin classes".
594:
805:
1607:"A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels"
1104:
Max EE, Battey J, Ney R, Kirsch IR, Leder P (June 1982). "Duplication and deletion in the human immunoglobulin epsilon genes".
774:
121:
96:
1393:"Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line"
1063:"The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes"
1258:"Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin"
727:, each heavy chain is bound to a light chain (kappa or lambda), the N terminus of the heavy chain is bound to a V segment.
770:
54:
134:
1689:
1438:"Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients"
127:
1508:"Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen"
428:
1720:
1682:
716:
110:
1215:"Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns"
957:
1351:
1141:
Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene".
996:
41:
1471:
Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, et al. (April 2002).
1340:"Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes"
1326:
1129:
1020:
70:
1391:
Kenten JH, Molgaard HV, Houghton M, Derbyshire RB, Viney J, Bell LO, Gould HJ (November 1982).
1725:
1636:
1593:
1558:
1529:
1494:
1459:
1424:
1379:
1318:
1289:
1244:
1201:
1158:
1121:
1092:
1049:
1012:
34:
1666:
1626:
1618:
1583:
1570:
Takhar P, Smurthwaite L, Coker HA, Fear DJ, Banfield GK, Carr VA, et al. (April 2005).
1550:
1519:
1484:
1449:
1436:
Valenta R, Natter S, Seiberler S, Wichlas S, Maurer D, Hess M, et al. (December 1998).
1414:
1404:
1369:
1359:
1310:
1279:
1269:
1234:
1226:
1191:
1183:
1150:
1113:
1082:
1074:
1041:
1004:
738:
214:
145:
867:
724:
690:
189:
66:
820:"IGHE immunoglobulin heavy constant epsilon [Homo sapiens (human)] - Gene - NCBI"
1605:
Batra J, Rajpoot R, Ahluwalia J, Devarapu SK, Sharma SK, Dinda AK, Ghosh B (June 2007).
1355:
1172:"Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA"
1000:
1631:
1606:
1230:
1078:
706:
1419:
1392:
1374:
1339:
1284:
1257:
1239:
1214:
1196:
1171:
1170:
Seno M, Kurokawa T, Ono Y, Onda H, Sasada R, Igarashi K, et al. (February 1983).
1087:
1062:
1709:
1454:
1437:
1314:
1117:
1045:
1330:
1133:
1024:
686:
207:
87:
1572:"Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis"
843:
819:
719:, member of the IGH constant gene cluster (component on the cluster), forming an
74:
1588:
1571:
1473:"Positive association to IgE levels and a physical map of the 13q14 atopy locus"
792:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1554:
1397:
Proceedings of the
National Academy of Sciences of the United States of America
1344:
Proceedings of the
National Academy of Sciences of the United States of America
1262:
Proceedings of the
National Academy of Sciences of the United States of America
668:
1032:
Padlan EA, Davies DR (October 1986). "A model of the Fc of immunoglobulin E".
681:
104:
1622:
1489:
1472:
1409:
1274:
1154:
720:
349:
307:
228:
173:
160:
62:
1640:
1597:
1562:
1533:
1498:
1364:
1187:
1524:
1507:
1463:
1428:
1383:
1322:
1293:
1248:
1205:
1162:
1125:
1096:
1053:
1016:
637:
1256:
Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983).
626:
1662:
655:
457:
414:
1654:
1008:
607:
371:
475:
471:
667:
662:
58:
1506:
Cocco RR, JΓ€rvinen KM, Sampson HA, Beyer K (August 2003).
680:
IGHE (Immunoglobulin Heavy constant
Epsilon), (located on
806:"Entrez Gene: IGHE immunoglobulin heavy constant epsilon"
1213:
Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984).
197:
1670:
319:
572:
553:
529:
510:
766:
764:
762:
944:American Academy of Allergy Asthma and Immunology
144:
741:are antibodies produced by the immune system.
1543:The Journal of Allergy and Clinical Immunology
1512:The Journal of Allergy and Clinical Immunology
1690:
8:
703:IGHE (immunoglobulin heavy constant epsilon)
45:, IgE, immunoglobulin heavy constant epsilon
771:GRCh38: Ensembl release 89: ENSG00000211891
1697:
1683:
345:
185:
82:
1630:
1587:
1523:
1488:
1453:
1418:
1408:
1373:
1363:
1283:
1273:
1238:
1195:
1086:
715:is a type of functioning gene, with four
1442:The Journal of Investigative Dermatology
962:The Children's Hospital of Philadelphia
758:
916:"Introduction to Immunoglobulins - US"
892:"Introduction to Immunoglobulins - US"
15:
149:
108:
103:
7:
1651:
1649:
723:of two E heavy chains bound by two
1669:. You can help Knowledge (XXG) by
1477:European Journal of Human Genetics
1231:10.1002/j.1460-2075.1982.tb01352.x
1079:10.1002/j.1460-2075.1982.tb01223.x
709:) called Immunoglobulin E, or IgE.
569:
550:
526:
507:
485:
462:
438:
419:
395:
376:
324:
285:
223:
202:
14:
1061:Flanagan JG, Rabbitts TH (1984).
658:that in humans is encoded by the
1653:
1455:10.1046/j.1523-1747.1998.00413.x
1338:Ellison J, Hood L (March 1982).
940:"Immunoglobulin E (IgE) Defined"
872:genatlas.medecine.univ-paris5.fr
133:
126:
120:
95:
308:More reference expression data
1:
958:"IgE-Mediated Food Allergies"
118:
1716:Genes on human chromosome 14
1315:10.1016/0092-8674(84)90348-9
1118:10.1016/0092-8674(82)90185-4
1046:10.1016/0161-5890(86)90005-2
1611:Journal of Medical Genetics
1589:10.4049/jimmunol.174.8.5024
1742:
1648:
1555:10.1016/j.jaci.2004.05.034
247:mucosa of transverse colon
788:"Human PubMed Reference:"
652:Ig epsilon chain C region
641:
636:
632:
625:
606:
589:
576:
557:
546:
533:
514:
503:
492:
488:
469:
465:
456:
445:
441:
426:
422:
413:
402:
398:
383:
379:
370:
355:
348:
344:
332:
327:
318:
305:
292:
288:
235:
226:
196:
188:
184:
167:
154:
117:
94:
85:
81:
52:
49:
39:
32:
27:
23:
18:
595:Chr 14: 105.6 β 105.6 Mb
1623:10.1136/jmg.2006.046607
1490:10.1038/sj.ejhg.5200801
1410:10.1073/pnas.79.21.6661
1275:10.1073/pnas.80.10.2995
1155:10.1089/dna.1.1981.1.11
1665:-related article is a
1365:10.1073/pnas.79.6.1984
1176:Nucleic Acids Research
739:Immunoglobulin E (IgE)
672:
1576:Journal of Immunology
1525:10.1067/mai.2003.1617
671:
111:Chromosome 14 (human)
1188:10.1093/nar/11.3.719
1034:Molecular Immunology
920:www.thermofisher.com
896:www.thermofisher.com
824:www.ncbi.nlm.nih.gov
1356:1982PNAS...79.1984E
1001:1991Natur.352..777V
673:
1678:
1677:
1403:(21): 6661β6665.
1268:(10): 2995β2999.
1225:(12): 1539β1544.
1040:(10): 1063β1075.
995:(6338): 777β781.
649:
648:
645:
644:
621:
620:
585:
584:
566:
565:
542:
541:
523:
522:
499:
498:
482:
481:
452:
451:
435:
434:
409:
408:
392:
391:
340:
339:
336:
335:
314:
313:
301:
300:
282:
281:
243:bone marrow cells
180:
179:
1733:
1699:
1692:
1685:
1657:
1650:
1644:
1634:
1601:
1591:
1582:(8): 5024β5032.
1566:
1537:
1527:
1502:
1492:
1467:
1457:
1448:(6): 1178β1183.
1432:
1422:
1412:
1387:
1377:
1367:
1350:(6): 1984β1988.
1334:
1297:
1287:
1277:
1252:
1242:
1219:The EMBO Journal
1209:
1199:
1166:
1137:
1100:
1090:
1067:The EMBO Journal
1057:
1028:
1009:10.1038/352777a0
973:
972:
970:
969:
954:
948:
947:
936:
930:
929:
927:
926:
912:
906:
905:
903:
902:
888:
882:
881:
879:
878:
868:"Genatlas sheet"
864:
858:
857:
855:
854:
840:
834:
833:
831:
830:
816:
810:
809:
802:
796:
795:
784:
778:
768:
634:
633:
617:
602:
597:
580:
570:
561:
551:
547:RefSeq (protein)
537:
527:
518:
508:
486:
463:
439:
420:
396:
377:
346:
325:
310:
286:
231:
229:Top expressed in
224:
203:
186:
176:
163:
152:
137:
130:
124:
113:
99:
83:
77:
75:IGHE - orthologs
44:
37:
16:
1741:
1740:
1736:
1735:
1734:
1732:
1731:
1730:
1706:
1705:
1704:
1703:
1647:
1604:
1569:
1540:
1505:
1470:
1435:
1390:
1337:
1300:
1255:
1212:
1169:
1140:
1103:
1060:
1031:
986:
982:
980:Further reading
977:
976:
967:
965:
956:
955:
951:
938:
937:
933:
924:
922:
914:
913:
909:
900:
898:
890:
889:
885:
876:
874:
866:
865:
861:
852:
850:
848:www.uniprot.org
842:
841:
837:
828:
826:
818:
817:
813:
804:
803:
799:
786:
785:
781:
769:
760:
755:
734:
725:disulfide bonds
699:
691:plasma membrane
678:
638:View/Edit Human
615:
600:
593:
590:Location (UCSC)
578:
559:
535:
516:
474:
429:ENSG00000211891
306:
297:
278:
273:
269:
265:
261:
257:
253:
249:
245:
241:
227:
171:
158:
150:
140:
139:
138:
131:
109:
86:Gene location (
53:
40:
33:
12:
11:
5:
1739:
1737:
1729:
1728:
1723:
1718:
1708:
1707:
1702:
1701:
1694:
1687:
1679:
1676:
1675:
1658:
1646:
1645:
1617:(6): 397β403.
1602:
1567:
1549:(3): 657β663.
1538:
1518:(2): 433β437.
1503:
1483:(4): 266β270.
1468:
1433:
1388:
1335:
1309:(3): 681β688.
1298:
1253:
1210:
1182:(3): 719β726.
1167:
1138:
1112:(2): 691β699.
1101:
1073:(5): 655β660.
1058:
1029:
983:
981:
978:
975:
974:
949:
931:
907:
883:
859:
835:
811:
797:
779:
757:
756:
754:
751:
733:
730:
729:
728:
710:
707:immunoglobulin
698:
695:
677:
674:
647:
646:
643:
642:
640:
630:
629:
623:
622:
619:
618:
613:
611:
604:
603:
598:
591:
587:
586:
583:
582:
574:
573:
567:
564:
563:
555:
554:
548:
544:
543:
540:
539:
531:
530:
524:
521:
520:
512:
511:
505:
501:
500:
497:
496:
490:
489:
483:
480:
479:
467:
466:
460:
454:
453:
450:
449:
443:
442:
436:
433:
432:
424:
423:
417:
411:
410:
407:
406:
400:
399:
393:
390:
389:
381:
380:
374:
368:
367:
362:
357:
353:
352:
342:
341:
338:
337:
334:
333:
330:
329:
322:
316:
315:
312:
311:
303:
302:
299:
298:
296:
293:
290:
289:
283:
280:
279:
277:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
233:
232:
220:
219:
211:
200:
194:
193:
190:RNA expression
182:
181:
178:
177:
169:
165:
164:
156:
153:
148:
142:
141:
132:
125:
119:
115:
114:
107:
101:
100:
92:
91:
79:
78:
51:
47:
46:
38:
30:
29:
25:
24:
21:
20:
13:
10:
9:
6:
4:
3:
2:
1738:
1727:
1724:
1722:
1721:Protein stubs
1719:
1717:
1714:
1713:
1711:
1700:
1695:
1693:
1688:
1686:
1681:
1680:
1674:
1672:
1668:
1664:
1659:
1656:
1652:
1642:
1638:
1633:
1628:
1624:
1620:
1616:
1612:
1608:
1603:
1599:
1595:
1590:
1585:
1581:
1577:
1573:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1539:
1535:
1531:
1526:
1521:
1517:
1513:
1509:
1504:
1500:
1496:
1491:
1486:
1482:
1478:
1474:
1469:
1465:
1461:
1456:
1451:
1447:
1443:
1439:
1434:
1430:
1426:
1421:
1416:
1411:
1406:
1402:
1398:
1394:
1389:
1385:
1381:
1376:
1371:
1366:
1361:
1357:
1353:
1349:
1345:
1341:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1299:
1295:
1291:
1286:
1281:
1276:
1271:
1267:
1263:
1259:
1254:
1250:
1246:
1241:
1236:
1232:
1228:
1224:
1220:
1216:
1211:
1207:
1203:
1198:
1193:
1189:
1185:
1181:
1177:
1173:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1139:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1102:
1098:
1094:
1089:
1084:
1080:
1076:
1072:
1068:
1064:
1059:
1055:
1051:
1047:
1043:
1039:
1035:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
985:
984:
979:
963:
959:
953:
950:
945:
941:
935:
932:
921:
917:
911:
908:
897:
893:
887:
884:
873:
869:
863:
860:
849:
845:
839:
836:
825:
821:
815:
812:
807:
801:
798:
793:
789:
783:
780:
776:
772:
767:
765:
763:
759:
752:
750:
746:
742:
740:
731:
726:
722:
718:
714:
711:
708:
704:
701:
700:
696:
694:
692:
688:
683:
675:
670:
666:
664:
661:
657:
653:
639:
635:
631:
628:
624:
614:
612:
609:
605:
599:
596:
592:
588:
581:
575:
571:
568:
562:
556:
552:
549:
545:
538:
532:
528:
525:
519:
513:
509:
506:
504:RefSeq (mRNA)
502:
495:
491:
487:
484:
478:
477:
473:
468:
464:
461:
459:
455:
448:
444:
440:
437:
431:
430:
425:
421:
418:
416:
412:
405:
401:
397:
394:
388:
387:
382:
378:
375:
373:
369:
366:
363:
361:
358:
354:
351:
347:
343:
331:
326:
323:
321:
317:
309:
304:
294:
291:
287:
284:
275:thyroid gland
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
237:
234:
230:
225:
222:
221:
218:
216:
212:
210:
209:
205:
204:
201:
199:
195:
191:
187:
183:
175:
170:
166:
162:
157:
147:
143:
136:
129:
123:
116:
112:
106:
102:
98:
93:
89:
84:
80:
76:
72:
68:
64:
60:
56:
48:
43:
36:
31:
26:
22:
17:
1671:expanding it
1660:
1614:
1610:
1579:
1575:
1546:
1542:
1515:
1511:
1480:
1476:
1445:
1441:
1400:
1396:
1347:
1343:
1306:
1302:
1265:
1261:
1222:
1218:
1179:
1175:
1149:(1): 11β18.
1146:
1142:
1109:
1105:
1070:
1066:
1037:
1033:
992:
988:
966:. Retrieved
964:. 2014-03-30
961:
952:
943:
934:
923:. Retrieved
919:
910:
899:. Retrieved
895:
886:
875:. Retrieved
871:
862:
851:. Retrieved
847:
838:
827:. Retrieved
823:
814:
800:
791:
782:
747:
743:
735:
712:
702:
687:phagocytosis
679:
659:
651:
650:
577:
558:
534:
515:
493:
470:
446:
427:
403:
384:
364:
359:
213:
206:
172:105,601,728
159:105,597,691
50:External IDs
263:granulocyte
28:Identifiers
1710:Categories
968:2023-11-02
925:2023-11-02
901:2023-11-02
877:2023-11-02
853:2023-10-17
829:2023-10-17
777:, May 2017
753:References
717:Ig domains
682:chromosome
267:lymph node
217:(ortholog)
844:"UniProt"
732:Allergies
721:homodimer
697:Structure
350:Orthologs
63:GeneCards
1726:Proteins
1641:17220216
1598:15814733
1563:15356573
1534:12897753
1499:12032735
1331:54312675
1134:54345379
773:–
676:Function
627:Wikidata
251:appendix
239:testicle
151:14q32.33
1663:protein
1632:2740889
1464:9856836
1429:6815656
1384:6804948
1352:Bibcode
1323:6421489
1294:6407005
1249:6327276
1206:6300763
1163:6299662
1126:6288268
1097:6234164
1054:3796618
1025:4246284
1017:1881434
997:Bibcode
775:Ensembl
656:protein
458:UniProt
415:Ensembl
356:Species
192:pattern
35:Aliases
1639:
1629:
1596:
1561:
1532:
1497:
1462:
1427:
1420:347188
1417:
1382:
1375:346106
1372:
1329:
1321:
1292:
1285:393960
1282:
1247:
1240:553248
1237:
1204:
1197:325748
1194:
1161:
1132:
1124:
1095:
1088:553102
1085:
1052:
1023:
1015:
989:Nature
610:search
608:PubMed
372:Entrez
320:BioGPS
255:spleen
59:147180
1661:This
1327:S2CID
1130:S2CID
1021:S2CID
654:is a
365:Mouse
360:Human
271:blood
259:gonad
215:Mouse
208:Human
155:Start
88:Human
1667:stub
1637:PMID
1594:PMID
1559:PMID
1530:PMID
1495:PMID
1460:PMID
1425:PMID
1380:PMID
1319:PMID
1303:Cell
1290:PMID
1245:PMID
1202:PMID
1159:PMID
1122:PMID
1106:Cell
1093:PMID
1050:PMID
1013:PMID
713:IGHE
663:gene
660:IGHE
386:3497
198:Bgee
146:Band
105:Chr.
67:IGHE
55:OMIM
42:IGHE
19:IGHE
1627:PMC
1619:doi
1584:doi
1580:174
1551:doi
1547:114
1520:doi
1516:112
1485:doi
1450:doi
1446:111
1415:PMC
1405:doi
1370:PMC
1360:doi
1311:doi
1280:PMC
1270:doi
1235:PMC
1227:doi
1192:PMC
1184:doi
1151:doi
1143:DNA
1114:doi
1083:PMC
1075:doi
1042:doi
1005:doi
993:352
693:.
616:n/a
601:n/a
579:n/a
560:n/a
536:n/a
517:n/a
494:n/a
447:n/a
404:n/a
328:n/a
295:n/a
168:End
71:OMA
1712::
1635:.
1625:.
1615:44
1613:.
1609:.
1592:.
1578:.
1574:.
1557:.
1545:.
1528:.
1514:.
1510:.
1493:.
1481:10
1479:.
1475:.
1458:.
1444:.
1440:.
1423:.
1413:.
1401:79
1399:.
1395:.
1378:.
1368:.
1358:.
1348:79
1346:.
1342:.
1325:.
1317:.
1307:36
1305:.
1288:.
1278:.
1266:80
1264:.
1260:.
1243:.
1233:.
1221:.
1217:.
1200:.
1190:.
1180:11
1178:.
1174:.
1157:.
1145:.
1128:.
1120:.
1110:29
1108:.
1091:.
1081:.
1069:.
1065:.
1048:.
1038:23
1036:.
1019:.
1011:.
1003:.
991:.
960:.
942:.
918:.
894:.
870:.
846:.
822:.
790:.
761:^
665:.
174:bp
161:bp
69:;
65::
61:;
57::
1698:e
1691:t
1684:v
1673:.
1643:.
1621::
1600:.
1586::
1565:.
1553::
1536:.
1522::
1501:.
1487::
1466:.
1452::
1431:.
1407::
1386:.
1362::
1354::
1333:.
1313::
1296:.
1272::
1251:.
1229::
1223:1
1208:.
1186::
1165:.
1153::
1147:1
1136:.
1116::
1099:.
1077::
1071:1
1056:.
1044::
1027:.
1007::
999::
971:.
946:.
928:.
904:.
880:.
856:.
832:.
808:.
794:.
476:a
472:n
90:)
73::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
