257:
234:
131:
156:
1069:. IL-31RA binds IL-31 through its cytokine binding domain (CBD). OSMR does not normally bind to IL-31 but it does increase the IL-31 binding affinity to IL-31RA. IL-31RA has an intracellular domain that possesses a box1 motif that mediates association with kinases of the JAK family. Additionally, the intracellular portion of the IL-31RA contains tyrosine residues. When IL-31 binds to the receptor complex, JAK kinases are activated which phosphorylate and activate
263:
162:
1021:, ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), and neuropoietin (NP). The anti-parallel bundles that these proteins form have an "up-up-down-down" topology, which is a relevant structure regarding the cytokine binding to their respective receptor complex. The cytokines in the IL-6 family signal through
1189:. The chemokines transcribed from these genes recruit T-cells to the irritated skin where they secrete more IL-31. This cycle is the current understanding of IL-31's role in atopic dermatitis. Along with atopic dermatitis, IL-31 is believed to play a role in inflammatory bowel disease and airway hypersensitivity.
1106:
via the phosphorylated tyrosines on its intracellular domain. Through Shc, the RAS/RAF/MEK/ERK pathway is activated along with the p38 and JNK pathways. When IL-31 binds to the IL-31RA/OSMR complex, the JAK, PI3K/AKT, and ERK signaling pathways are activated. The pathways allow for target genes to be
1195:
forms of inflammatory skin diseases, or itchy skin diseases, have been found to have elevated levels of IL-31 mRNA in patient biopsies. Analysis of the tissue distribution of the IL-31 receptor complex found that IL-31RA is abundant in dorsal root ganglia of different human tissues.
1177:, or eczema. When biopsy samples of patients with atopic dermatitis were compared to samples from patients without atopic dermatitis, levels of IL-31 were elevated in patients with atopic dermatitis. IL-31 plays a role in this disease by inducing chemokine genes
1045:. IL-31RA was originally referred to as GLM-R (for gp130-like monocyte receptor) or GPL (for gp130-like receptor). Although the IL-31 receptor complex lacks gp130, IL-31RA has similarities to gp130 like its previous descriptors suggest.
1089:
to bind, which are recruited once the tyrosine residues on the intracellular domain are phosphorylated. Through these phosphorylation sites, STAT3 and STAT5 are recruited and phosphorylated by JAK1 and JAK2. In addition to STATs,
1037:, which is important for activating downstream signaling pathways. IL-31 is unique in this family of cytokines because its receptor complex does not contain gp130. The receptor for IL-31 is a heterodimer of the
1329:
Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, et al. (July 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice".
2745:
1204:
reside. Dorsal root ganglia are also believed to be where the "itch" sensation originates. These findings support the elevated levels of IL-31 in skin biopsies of pruritic skin diseases.
270:
169:
2134:
2738:
1589:
A blinded, randomized clinical trial evaluationg the efficacy and safety of lokivetmab compared to ciclosporin in client owned dogs with atopic dermatitis.
634:
653:
92:
2731:
2210:
3943:
3210:
2605:
1273:
4008:
3947:
3933:
3893:
1291:
3962:
1630:
853:
256:
3867:
1509:
860:
2815:
2496:
1312:
233:
2026:
1260:
1239:
155:
130:
1256:
3828:
3807:
1803:
1235:
1150:. It major sites of action are the skin, lung, intestine and the nervous system. Hence IL-31 main role is to facilitate
72:
2639:
2189:
1964:
1403:
Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B (June 2012). "Signaling by IL-31 and functional consequences".
269:
168:
2672:
2474:
2184:
1014:
2593:
2278:
1552:
Hermanns HM (2015). "Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology".
262:
161:
2628:
2055:
2031:
1030:
1022:
698:
80:
1081:. The OSMR portion of the IL-31 binding complex contains intracellular motifs box1 and box2. This allows for
3786:
3746:
3725:
3669:
3637:
3596:
3554:
3508:
3427:
3401:
3345:
3304:
3278:
3252:
2906:
1623:
1108:
1038:
679:
3361:
3221:
3201:
3180:
3099:
3038:
2982:
2936:
2860:
2765:
1956:
1151:
935:
1507:
Rabenhorst A, Hartmann K (April 2014). "Interleukin-31: a novel diagnostic marker of allergic diseases".
4013:
1120:
1095:
1091:
1058:
1042:
962:
931:
144:
2871:
3983:
1025:. Type I cytokine receptors are defined by sharing their cytokine binding domain (CBD) with conserved
3766:
2754:
2482:
1197:
1033:
motif in the extracellular domain. The receptors form heteromeric complexes that usually contain the
939:
59:
2896:
3757:
3315:
3110:
2886:
2780:
2324:
1208:
815:
768:
3627:
3622:
3607:
3519:
3498:
2947:
2881:
2840:
2784:
2757:
2491:
2448:
2363:
2206:
2070:
1616:
1534:
1354:
104:
3488:
3356:
3263:
3242:
2993:
2962:
2957:
2901:
2820:
836:
789:
3534:
2967:
2795:
2790:
3140:
3125:
3089:
3059:
2805:
2355:
1974:
1840:
1569:
1526:
1486:
1420:
1346:
1174:
943:
52:
28:
3978:
2667:
2588:
2456:
2145:
1979:
1597:
1588:
1561:
1518:
1476:
1468:
1412:
1338:
1066:
1034:
974:
970:
349:
280:
224:
179:
3454:
3450:
3446:
3770:
2194:
1880:
966:
324:
100:
938:
against pathogens. It has also been identified as a major player in a number of chronic
3968:
3958:
3953:
3939:
3925:
3915:
3910:
3857:
3839:
3818:
3776:
3762:
3736:
3680:
3648:
3612:
3575:
3570:
3565:
3529:
3524:
3438:
3417:
3371:
3320:
3289:
3268:
3003:
2972:
2708:
2703:
2558:
2554:
2536:
2531:
2334:
2329:
2319:
2314:
2309:
2304:
2299:
2295:
2264:
2259:
2254:
2233:
2228:
2223:
2218:
2168:
2163:
2158:
2106:
2091:
2082:
1639:
1481:
1456:
1147:
1086:
1082:
1010:
1006:
982:
978:
568:
563:
558:
542:
537:
521:
516:
4002:
3710:
3366:
3232:
3191:
3115:
3049:
2998:
2952:
2891:
2776:
2698:
2693:
2688:
2634:
2583:
2249:
2153:
2129:
2124:
2101:
2096:
2087:
2078:
1860:
1158:
1131:
1002:
950:
503:
1538:
1358:
84:
3884:
3705:
3391:
3386:
3381:
3130:
3069:
3028:
2179:
2011:
1170:
1127:
1018:
998:
342:
121:
2723:
1565:
1472:
108:
3715:
3695:
3658:
3493:
3483:
3335:
3330:
3165:
3135:
3074:
2916:
2876:
2835:
2830:
2600:
2546:
2287:
2046:
1969:
1296:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1278:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1416:
401:
3700:
3690:
3585:
3478:
3473:
3294:
3155:
3145:
3079:
3013:
2926:
2921:
2850:
2653:
2346:
2036:
1996:
1522:
1212:
1143:
241:
138:
88:
3170:
3160:
3150:
3023:
1658:
1608:
1139:
1062:
598:
461:
363:
308:
295:
207:
194:
96:
1573:
1530:
1490:
1424:
1350:
1053:
IL-31 signals via a receptor complex that is composed of IL-31 receptor A (
900:
895:
2810:
2648:
1643:
1026:
994:
884:
743:
724:
3929:
3412:
920:
710:
665:
1601:
3544:
2526:
2423:
2418:
2413:
2408:
2403:
2398:
2116:
1921:
1905:
1900:
1895:
1890:
1885:
1875:
1870:
1201:
1099:
1054:
958:
868:
620:
17:
1061:(OSMR) subunits. These receptor subunits are expressed in activated
1342:
3851:
3847:
3843:
3462:
3458:
3442:
2562:
2521:
2516:
2511:
2506:
2501:
2438:
2428:
2393:
2388:
2383:
2378:
2373:
2368:
2021:
2016:
2006:
1991:
1986:
1865:
1855:
1850:
1845:
1835:
1830:
1824:
1808:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1722:
1457:"Structures and biological functions of IL-31 and IL-31 receptors"
1186:
1182:
1078:
1074:
1070:
1001:
structure in the gp130/IL-6 cytokine family. This family includes
957:) T-cells. IL-31 sends signals through a receptor complex made of
583:
579:
2486:
2433:
2001:
1942:
1937:
1717:
1712:
1707:
1702:
1696:
1690:
1684:
1678:
1673:
1192:
1178:
1103:
927:
76:
2727:
1612:
949:
IL-31 is produced by a variety of cells, namely type 2 helper (
3919:
1124:
1215:
is available for the treatment of canine atopic dermatitis.
1455:
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W (October 2008).
1157:
IL-31 and its receptors are also involved in regulating
332:
473:
3903:
3883:
3876:
3827:
3806:
3785:
3745:
3724:
3668:
3636:
3595:
3553:
3507:
3426:
3400:
3344:
3303:
3277:
3251:
3220:
3200:
3179:
3098:
3037:
2981:
2935:
2859:
2764:
2618:
2576:
2545:
2473:
2447:
2354:
2345:
2286:
2277:
2242:
2205:
2143:
2115:
2069:
2054:
2045:
1955:
1930:
1914:
1817:
1666:
1657:
1650:
1398:
1396:
1394:
1392:
1390:
1388:
829:
808:
782:
761:
1386:
1384:
1382:
1380:
1378:
1376:
1374:
1372:
1370:
1368:
1252:
1250:
1248:
1231:
1229:
1227:
1502:
1500:
279:
178:
1257:GRCm38: Ensembl release 89: ENSMUSG00000029437
1102:, the OSMR interacts with the adaptor protein
2739:
1624:
1324:
1322:
8:
1450:
1448:
1446:
1444:
1442:
1440:
1438:
1436:
1434:
1200:is where the cell bodies of primary sensory
1169:IL-31 is believed to play a role in chronic
1236:GRCh38: Ensembl release 89: ENSG00000204671
930:that resides on chromosome 12. IL-31 is an
3880:
2746:
2732:
2724:
2351:
2283:
2066:
2051:
1663:
1654:
1631:
1617:
1609:
594:
499:
320:
219:
116:
27:"IL-31" redirects here. For the road, see
1480:
969:. These signals activate three pathways:
564:regulation of signaling receptor activity
3911:Interleukin 14 (taxilin alpha, HMW-BCGF)
1307:
1305:
1223:
1039:interleukin 31 receptor alpha (IL-31RA)
3209:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1098:. In contrast to IL-31RA, which binds
33:
284:
245:
240:
183:
142:
137:
7:
1554:Cytokine & Growth Factor Reviews
1461:Cytokine & Growth Factor Reviews
1173:diseases. One of these diseases is
1094:is recruited, which stimulates the
569:cytokine-mediated signaling pathway
1510:Current Allergy and Asthma Reports
965:β (OSMRβ) expressed in immune and
826:
805:
779:
758:
734:
715:
689:
670:
644:
625:
478:
396:
358:
337:
25:
923:that in humans is encoded by the
1405:European Journal of Cell Biology
268:
261:
255:
232:
167:
160:
154:
129:
3737:Interleukin 27 (interleukin 30)
1013:, leukemia inhibitory factor (
462:More reference expression data
1:
1566:10.1016/j.cytogfr.2015.07.006
1473:10.1016/j.cytogfr.2008.08.003
1313:"Entrez Gene: interleukin 31"
1161:progenitor cell homeostasis.
253:
152:
4009:Genes on human chromosome 12
378:human musculoskeletal system
3087:Antisense oligonucleotides:
4030:
1417:10.1016/j.ejcb.2011.07.006
1130:, in particular activated
1096:PI3K/AKT signaling pathway
854:Chr 12: 122.17 – 122.17 Mb
26:
2594:Colony-stimulating factor
1523:10.1007/s11882-014-0423-y
1292:"Mouse PubMed Reference:"
1274:"Human PubMed Reference:"
1029:residues and a conserved
1023:type I cytokine receptors
899:
894:
890:
883:
867:
861:Chr 5: 123.62 – 123.63 Mb
848:
833:
812:
801:
786:
765:
754:
741:
737:
722:
718:
709:
696:
692:
677:
673:
664:
651:
647:
632:
628:
619:
604:
597:
593:
577:
522:cytokine receptor binding
502:
498:
486:
481:
472:
459:
408:
399:
370:
361:
331:
323:
319:
302:
289:
252:
231:
222:
218:
201:
188:
151:
128:
119:
115:
70:
67:
57:
50:
45:
41:
36:
2629:proinflammatory cytokine
1035:glycoprotein 130 (gp130)
3777:Interleukin-29 (IFN-λ1)
2922:Daclizumab (dacliximab)
2907:Tucotuzumab celmoleukin
63:, IL-31, interleukin 31
3758:Interferon λ4 (IFN-λ4)
2851:Rilonacept (IL-1 Trap)
1760:/PARC/DCCK1/AMAC1/MIP4
1586:Hilde Moyaert et al.:
1152:cell-mediated immunity
1123:produced by activated
997:with an anti-parallel
936:cell-mediated immunity
3681:Interleukin 23 (SGRF)
3362:Cintredekin besudotox
3290:Interleukin 11 (AGIF)
3269:Interleukin 10 (CSIF)
1165:Clinical significance
1121:inflammatory cytokine
1119:Interleukin 31 is an
1059:oncostatin M receptor
963:oncostatin M receptor
940:inflammatory diseases
932:inflammatory cytokine
559:immune system process
440:telencephalic nucleus
145:Chromosome 12 (human)
2755:Interleukin receptor
1211:against IL-31 named
1065:and in unstimulated
985:signaling pathways.
538:extracellular region
382:gastrocnemius muscle
247:Chromosome 5 (mouse)
2887:Denileukin diftitox
2325:Interferon type III
1209:monoclonal antibody
1198:Dorsal root ganglia
1154:against pathogens.
934:that helps trigger
543:extracellular space
432:islet of Langerhans
420:seminiferous tubule
386:islet of Langerhans
3459:E (interleukin 25)
1019:oncostatin M (OSM)
699:ENSMUSG00000029437
552:Biological process
531:Cellular component
510:Molecular function
3996:
3995:
3992:
3991:
3961:(signals through
3942:(signals through
3928:(signals through
3918:(signals through
3542:Binding proteins:
2872:Adargileukin alfa
2721:
2720:
2614:
2613:
2572:
2571:
2469:
2468:
2465:
2464:
2273:
2272:
1951:
1950:
1602:10.1111/vde.12478
1596:, September 2017
1331:Nature Immunology
1175:atopic dermatitis
999:four-helix bundle
971:ERK1/2 MAP kinase
944:atopic dermatitis
910:
909:
906:
905:
879:
878:
844:
843:
823:
822:
797:
796:
776:
775:
750:
749:
731:
730:
705:
704:
686:
685:
660:
659:
641:
640:
589:
588:
517:cytokine activity
494:
493:
490:
489:
468:
467:
455:
454:
393:
392:
315:
314:
214:
213:
29:Illinois Route 31
16:(Redirected from
4021:
3984:Efineptakin alfa
3979:Efavaleukin alfa
3881:
2848:Decoy receptors:
2748:
2741:
2734:
2725:
2352:
2284:
2067:
2052:
1664:
1655:
1633:
1626:
1619:
1610:
1604:
1594:Vet. Dermatology
1584:
1578:
1577:
1549:
1543:
1542:
1504:
1495:
1494:
1484:
1452:
1429:
1428:
1400:
1363:
1362:
1326:
1317:
1316:
1309:
1300:
1299:
1288:
1282:
1281:
1270:
1264:
1254:
1243:
1233:
1067:epithelial cells
967:epithelial cells
892:
891:
863:
856:
839:
827:
818:
806:
802:RefSeq (protein)
792:
780:
771:
759:
735:
716:
690:
671:
645:
626:
595:
500:
479:
464:
436:nucleus of brain
404:
402:Top expressed in
397:
366:
364:Top expressed in
359:
338:
321:
311:
298:
287:
272:
265:
259:
248:
236:
220:
210:
197:
186:
171:
164:
158:
147:
133:
117:
111:
109:IL31 - orthologs
62:
55:
34:
21:
4029:
4028:
4024:
4023:
4022:
4020:
4019:
4018:
3999:
3998:
3997:
3988:
3899:
3872:
3823:
3802:
3781:
3741:
3720:
3664:
3661:(against IL-22)
3632:
3591:
3588:(against IL-20)
3549:
3503:
3422:
3396:
3340:
3299:
3273:
3247:
3216:
3196:
3175:
3094:
3033:
2977:
2931:
2855:
2760:
2752:
2722:
2717:
2683:
2662:
2620:
2610:
2568:
2541:
2461:
2443:
2341:
2269:
2238:
2201:
2139:
2111:
2062:
2060:
2058:
2041:
1947:
1926:
1910:
1813:
1646:
1637:
1607:
1585:
1581:
1551:
1550:
1546:
1506:
1505:
1498:
1467:(5–6): 347–56.
1454:
1453:
1432:
1411:(6–7): 552–66.
1402:
1401:
1366:
1328:
1327:
1320:
1311:
1310:
1303:
1290:
1289:
1285:
1272:
1271:
1267:
1255:
1246:
1234:
1225:
1221:
1167:
1148:dendritic cells
1135:
1117:
1051:
991:
954:
901:View/Edit Mouse
896:View/Edit Human
859:
852:
849:Location (UCSC)
835:
814:
788:
767:
680:ENSG00000204671
573:
547:
526:
460:
451:
448:basal forebrain
446:
442:
438:
434:
430:
426:
422:
418:
414:
400:
389:
384:
380:
376:
362:
306:
293:
285:
275:
274:
273:
266:
246:
223:Gene location (
205:
192:
184:
174:
173:
172:
165:
143:
120:Gene location (
71:
58:
51:
32:
23:
22:
15:
12:
11:
5:
4027:
4025:
4017:
4016:
4011:
4001:
4000:
3994:
3993:
3990:
3989:
3987:
3986:
3981:
3972:
3971:
3969:Interleukin 35
3966:
3959:Interleukin 34
3956:
3954:Interleukin 32
3951:
3940:Interleukin 26
3937:
3926:Interleukin 24
3923:
3916:Interleukin 16
3913:
3907:
3905:
3901:
3900:
3898:
3897:
3889:
3887:
3878:
3874:
3873:
3871:
3870:
3861:
3860:
3858:Interleukin 38
3855:
3840:Interleukin 36
3833:
3831:
3825:
3824:
3822:
3821:
3819:Interleukin 33
3812:
3810:
3804:
3803:
3801:
3800:
3798:Interleukin 31
3791:
3789:
3783:
3782:
3780:
3779:
3774:
3763:Interleukin 28
3760:
3751:
3749:
3743:
3742:
3740:
3739:
3730:
3728:
3722:
3721:
3719:
3718:
3713:
3708:
3703:
3698:
3693:
3684:
3683:
3674:
3672:
3666:
3665:
3663:
3662:
3652:
3651:
3649:Interleukin 22
3642:
3640:
3634:
3633:
3631:
3630:
3625:
3616:
3615:
3613:Interleukin 21
3610:
3601:
3599:
3593:
3592:
3590:
3589:
3579:
3578:
3576:Interleukin 24
3573:
3571:Interleukin 20
3568:
3566:Interleukin 19
3559:
3557:
3551:
3550:
3548:
3547:
3538:
3537:
3532:
3530:Interleukin 37
3527:
3525:Interleukin 18
3522:
3513:
3511:
3505:
3504:
3502:
3501:
3496:
3491:
3486:
3481:
3476:
3467:
3466:
3439:Interleukin 17
3432:
3430:
3424:
3423:
3421:
3420:
3418:Interleukin 15
3415:
3406:
3404:
3398:
3397:
3395:
3394:
3389:
3384:
3375:
3374:
3372:Interleukin 13
3369:
3364:
3359:
3350:
3348:
3342:
3341:
3339:
3338:
3333:
3324:
3323:
3321:Interleukin 12
3318:
3309:
3307:
3301:
3300:
3298:
3297:
3292:
3283:
3281:
3275:
3274:
3272:
3271:
3266:
3257:
3255:
3249:
3248:
3246:
3245:
3236:
3235:
3226:
3224:
3218:
3217:
3215:
3214:
3206:
3204:
3198:
3197:
3195:
3194:
3185:
3183:
3177:
3176:
3174:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3119:
3118:
3113:
3104:
3102:
3096:
3095:
3093:
3092:
3083:
3082:
3077:
3072:
3063:
3062:
3053:
3052:
3043:
3041:
3035:
3034:
3032:
3031:
3026:
3017:
3016:
3007:
3006:
3004:Interleukin 13
3001:
2996:
2987:
2985:
2979:
2978:
2976:
2975:
2973:Promegapoietin
2970:
2965:
2960:
2955:
2950:
2941:
2939:
2933:
2932:
2930:
2929:
2924:
2919:
2910:
2909:
2904:
2899:
2897:Pegaldesleukin
2894:
2889:
2884:
2879:
2874:
2865:
2863:
2857:
2856:
2854:
2853:
2844:
2843:
2838:
2833:
2824:
2823:
2818:
2813:
2808:
2799:
2798:
2793:
2788:
2770:
2768:
2762:
2761:
2753:
2751:
2750:
2743:
2736:
2728:
2719:
2718:
2716:
2715:
2714:
2713:
2712:
2711:
2706:
2701:
2696:
2691:
2681:
2677:
2676:
2675:
2670:
2660:
2651:
2645:
2644:
2643:
2642:
2637:
2624:
2622:
2616:
2615:
2612:
2611:
2609:
2608:
2603:
2598:
2597:
2596:
2591:
2580:
2578:
2574:
2573:
2570:
2569:
2567:
2566:
2551:
2549:
2543:
2542:
2540:
2539:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2479:
2477:
2475:Ig superfamily
2471:
2470:
2467:
2466:
2463:
2462:
2460:
2459:
2453:
2451:
2445:
2444:
2442:
2441:
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2366:
2360:
2358:
2349:
2343:
2342:
2340:
2339:
2338:
2337:
2332:
2322:
2317:
2312:
2307:
2302:
2292:
2290:
2281:
2275:
2274:
2271:
2270:
2268:
2267:
2262:
2257:
2252:
2246:
2244:
2240:
2239:
2237:
2236:
2231:
2226:
2221:
2215:
2213:
2203:
2202:
2200:
2199:
2198:
2197:
2192:
2187:
2182:
2171:
2166:
2161:
2156:
2150:
2148:
2141:
2140:
2138:
2137:
2132:
2127:
2121:
2119:
2113:
2112:
2110:
2109:
2104:
2099:
2094:
2085:
2075:
2073:
2064:
2049:
2043:
2042:
2040:
2039:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1999:
1994:
1989:
1984:
1983:
1982:
1977:
1967:
1961:
1959:
1953:
1952:
1949:
1948:
1946:
1945:
1940:
1934:
1932:
1928:
1927:
1925:
1924:
1918:
1916:
1912:
1911:
1909:
1908:
1903:
1898:
1893:
1888:
1883:
1878:
1873:
1868:
1863:
1858:
1853:
1848:
1843:
1838:
1833:
1828:
1821:
1819:
1815:
1814:
1812:
1811:
1806:
1801:
1796:
1791:
1786:
1781:
1776:
1771:
1766:
1761:
1755:
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1715:
1710:
1705:
1700:
1694:
1688:
1682:
1676:
1670:
1668:
1661:
1652:
1648:
1647:
1640:Cell signaling
1638:
1636:
1635:
1628:
1621:
1613:
1606:
1605:
1579:
1544:
1496:
1430:
1364:
1343:10.1038/ni1084
1318:
1301:
1283:
1265:
1244:
1222:
1220:
1217:
1166:
1163:
1136:2 helper cells
1133:
1116:
1113:
1050:
1047:
990:
987:
952:
913:Interleukin-31
908:
907:
904:
903:
898:
888:
887:
881:
880:
877:
876:
874:
872:
865:
864:
857:
850:
846:
845:
842:
841:
831:
830:
824:
821:
820:
810:
809:
803:
799:
798:
795:
794:
784:
783:
777:
774:
773:
763:
762:
756:
752:
751:
748:
747:
739:
738:
732:
729:
728:
720:
719:
713:
707:
706:
703:
702:
694:
693:
687:
684:
683:
675:
674:
668:
662:
661:
658:
657:
649:
648:
642:
639:
638:
630:
629:
623:
617:
616:
611:
606:
602:
601:
591:
590:
587:
586:
575:
574:
572:
571:
566:
561:
555:
553:
549:
548:
546:
545:
540:
534:
532:
528:
527:
525:
524:
519:
513:
511:
507:
506:
496:
495:
492:
491:
488:
487:
484:
483:
476:
470:
469:
466:
465:
457:
456:
453:
452:
450:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
409:
406:
405:
394:
391:
390:
388:
387:
383:
379:
375:
374:gastric mucosa
371:
368:
367:
355:
354:
346:
335:
329:
328:
325:RNA expression
317:
316:
313:
312:
304:
300:
299:
291:
288:
283:
277:
276:
267:
260:
254:
250:
249:
244:
238:
237:
229:
228:
216:
215:
212:
211:
203:
199:
198:
190:
187:
182:
176:
175:
166:
159:
153:
149:
148:
141:
135:
134:
126:
125:
113:
112:
69:
65:
64:
56:
48:
47:
43:
42:
39:
38:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4026:
4015:
4012:
4010:
4007:
4006:
4004:
3985:
3982:
3980:
3977:
3974:
3973:
3970:
3967:
3964:
3960:
3957:
3955:
3952:
3949:
3945:
3941:
3938:
3935:
3931:
3927:
3924:
3921:
3917:
3914:
3912:
3909:
3908:
3906:
3902:
3895:
3891:
3890:
3888:
3886:
3882:
3879:
3875:
3869:
3866:
3863:
3862:
3859:
3856:
3853:
3849:
3845:
3841:
3838:
3835:
3834:
3832:
3830:
3826:
3820:
3817:
3814:
3813:
3811:
3809:
3805:
3799:
3796:
3793:
3792:
3790:
3788:
3784:
3778:
3775:
3772:
3768:
3764:
3761:
3759:
3756:
3753:
3752:
3750:
3748:
3744:
3738:
3735:
3732:
3731:
3729:
3727:
3723:
3717:
3714:
3712:
3711:Tildrakizumab
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3686:
3685:
3682:
3679:
3676:
3675:
3673:
3671:
3667:
3660:
3657:
3654:
3653:
3650:
3647:
3644:
3643:
3641:
3639:
3635:
3629:
3626:
3624:
3621:
3618:
3617:
3614:
3611:
3609:
3606:
3603:
3602:
3600:
3598:
3594:
3587:
3584:
3581:
3580:
3577:
3574:
3572:
3569:
3567:
3564:
3561:
3560:
3558:
3556:
3552:
3546:
3543:
3540:
3539:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3515:
3514:
3512:
3510:
3506:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3469:
3468:
3464:
3460:
3456:
3452:
3448:
3444:
3440:
3437:
3434:
3433:
3431:
3429:
3425:
3419:
3416:
3414:
3411:
3408:
3407:
3405:
3403:
3399:
3393:
3390:
3388:
3385:
3383:
3380:
3377:
3376:
3373:
3370:
3368:
3367:Interleukin 4
3365:
3363:
3360:
3358:
3355:
3352:
3351:
3349:
3347:
3343:
3337:
3334:
3332:
3329:
3326:
3325:
3322:
3319:
3317:
3316:Edodekin alfa
3314:
3311:
3310:
3308:
3306:
3302:
3296:
3293:
3291:
3288:
3285:
3284:
3282:
3280:
3276:
3270:
3267:
3265:
3262:
3259:
3258:
3256:
3254:
3250:
3244:
3241:
3238:
3237:
3234:
3233:Interleukin 9
3231:
3228:
3227:
3225:
3223:
3219:
3212:
3208:
3207:
3205:
3203:
3199:
3193:
3192:Interleukin 7
3190:
3187:
3186:
3184:
3182:
3178:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3121:
3120:
3117:
3116:Interleukin 6
3114:
3112:
3111:Atexakin alfa
3109:
3106:
3105:
3103:
3101:
3097:
3091:
3088:
3085:
3084:
3081:
3078:
3076:
3073:
3071:
3068:
3065:
3064:
3061:
3058:
3055:
3054:
3051:
3050:Interleukin 5
3048:
3045:
3044:
3042:
3040:
3036:
3030:
3027:
3025:
3022:
3019:
3018:
3015:
3012:
3009:
3008:
3005:
3002:
3000:
2999:Interleukin 4
2997:
2995:
2992:
2989:
2988:
2986:
2984:
2980:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2953:Interleukin 3
2951:
2949:
2946:
2943:
2942:
2940:
2938:
2934:
2928:
2925:
2923:
2920:
2918:
2915:
2912:
2911:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2892:Interleukin 2
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2867:
2866:
2864:
2862:
2858:
2852:
2849:
2846:
2845:
2842:
2839:
2837:
2834:
2832:
2829:
2826:
2825:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2801:
2800:
2797:
2794:
2792:
2789:
2786:
2782:
2778:
2777:Interleukin 1
2775:
2772:
2771:
2769:
2767:
2763:
2759:
2756:
2749:
2744:
2742:
2737:
2735:
2730:
2729:
2726:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2686:
2685:
2678:
2674:
2671:
2669:
2666:
2665:
2664:
2657:
2656:
2655:
2652:
2650:
2647:
2646:
2641:
2638:
2636:
2633:
2632:
2631:
2630:
2626:
2625:
2623:
2617:
2607:
2604:
2602:
2599:
2595:
2592:
2590:
2587:
2586:
2585:
2584:Hematopoietic
2582:
2581:
2579:
2575:
2564:
2560:
2556:
2553:
2552:
2550:
2548:
2544:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2484:
2481:
2480:
2478:
2476:
2472:
2458:
2455:
2454:
2452:
2450:
2446:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2361:
2359:
2357:
2353:
2350:
2348:
2344:
2336:
2333:
2331:
2328:
2327:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2297:
2294:
2293:
2291:
2289:
2285:
2282:
2280:
2276:
2266:
2263:
2261:
2258:
2256:
2253:
2251:
2248:
2247:
2245:
2241:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2216:
2214:
2212:
2208:
2204:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2177:
2176:
2175:
2172:
2170:
2167:
2165:
2162:
2160:
2157:
2155:
2152:
2151:
2149:
2147:
2142:
2136:
2133:
2131:
2128:
2126:
2123:
2122:
2120:
2118:
2114:
2108:
2105:
2103:
2100:
2098:
2095:
2093:
2089:
2086:
2084:
2080:
2077:
2076:
2074:
2072:
2068:
2065:
2057:
2053:
2050:
2048:
2044:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1992:TNFSF5/CD40LG
1990:
1988:
1985:
1981:
1978:
1976:
1973:
1972:
1971:
1968:
1966:
1963:
1962:
1960:
1958:
1954:
1944:
1941:
1939:
1936:
1935:
1933:
1929:
1923:
1920:
1919:
1917:
1913:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1867:
1864:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1826:
1823:
1822:
1820:
1816:
1810:
1807:
1805:
1802:
1800:
1797:
1795:
1792:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1765:
1762:
1759:
1756:
1754:
1751:
1749:
1746:
1744:
1741:
1739:
1736:
1734:
1731:
1729:
1726:
1724:
1721:
1719:
1716:
1714:
1711:
1709:
1706:
1704:
1701:
1698:
1695:
1692:
1689:
1686:
1683:
1680:
1677:
1675:
1672:
1671:
1669:
1665:
1662:
1660:
1656:
1653:
1649:
1645:
1641:
1634:
1629:
1627:
1622:
1620:
1615:
1614:
1611:
1603:
1599:
1595:
1591:
1590:
1583:
1580:
1575:
1571:
1567:
1563:
1560:(5): 545–58.
1559:
1555:
1548:
1545:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1511:
1503:
1501:
1497:
1492:
1488:
1483:
1478:
1474:
1470:
1466:
1462:
1458:
1451:
1449:
1447:
1445:
1443:
1441:
1439:
1437:
1435:
1431:
1426:
1422:
1418:
1414:
1410:
1406:
1399:
1397:
1395:
1393:
1391:
1389:
1387:
1385:
1383:
1381:
1379:
1377:
1375:
1373:
1371:
1369:
1365:
1360:
1356:
1352:
1348:
1344:
1340:
1337:(7): 752–60.
1336:
1332:
1325:
1323:
1319:
1314:
1308:
1306:
1302:
1297:
1293:
1287:
1284:
1279:
1275:
1269:
1266:
1262:
1258:
1253:
1251:
1249:
1245:
1241:
1237:
1232:
1230:
1228:
1224:
1218:
1216:
1214:
1210:
1205:
1203:
1199:
1194:
1190:
1188:
1184:
1180:
1176:
1172:
1164:
1162:
1160:
1159:hematopoietic
1155:
1153:
1149:
1145:
1141:
1137:
1129:
1128:T lymphocytes
1126:
1122:
1114:
1112:
1110:
1105:
1101:
1097:
1093:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1048:
1046:
1044:
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
988:
986:
984:
980:
976:
972:
968:
964:
960:
956:
947:
945:
941:
937:
933:
929:
926:
922:
918:
914:
902:
897:
893:
889:
886:
882:
875:
873:
870:
866:
862:
858:
855:
851:
847:
840:
838:
832:
828:
825:
819:
817:
811:
807:
804:
800:
793:
791:
785:
781:
778:
772:
770:
764:
760:
757:
755:RefSeq (mRNA)
753:
746:
745:
740:
736:
733:
727:
726:
721:
717:
714:
712:
708:
701:
700:
695:
691:
688:
682:
681:
676:
672:
669:
667:
663:
656:
655:
650:
646:
643:
637:
636:
631:
627:
624:
622:
618:
615:
612:
610:
607:
603:
600:
596:
592:
585:
581:
576:
570:
567:
565:
562:
560:
557:
556:
554:
551:
550:
544:
541:
539:
536:
535:
533:
530:
529:
523:
520:
518:
515:
514:
512:
509:
508:
505:
504:Gene ontology
501:
497:
485:
480:
477:
475:
471:
463:
458:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
410:
407:
403:
398:
395:
385:
381:
377:
373:
372:
369:
365:
360:
357:
356:
353:
351:
347:
345:
344:
340:
339:
336:
334:
330:
326:
322:
318:
310:
305:
301:
297:
292:
282:
278:
271:
264:
258:
251:
243:
239:
235:
230:
226:
221:
217:
209:
204:
200:
196:
191:
181:
177:
170:
163:
157:
150:
146:
140:
136:
132:
127:
123:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
66:
61:
54:
49:
44:
40:
35:
30:
19:
4014:Interleukins
3975:
3963:M-CSFR/CSF1R
3950:heterodimer)
3936:heterodimer)
3865:Antagonists:
3864:
3836:
3815:
3797:
3794:
3754:
3733:
3706:Risankizumab
3687:
3677:
3655:
3645:
3628:NNC0114-0006
3623:NNC0114-0005
3619:
3604:
3582:
3562:
3541:
3516:
3470:
3435:
3409:
3392:Tralokinumab
3387:Lebrikizumab
3382:Anrukinzumab
3378:
3353:
3327:
3312:
3286:
3260:
3239:
3229:
3188:
3131:Clazakizumab
3122:
3107:
3086:
3070:Benralizumab
3066:
3057:Antagonists:
3056:
3046:
3029:Pascolizumab
3020:
3011:Antagonists:
3010:
2990:
2944:
2913:
2868:
2847:
2827:
2803:Antagonists:
2802:
2773:
2679:
2658:
2627:
2619:By function/
2330:IL28/IFNL2+3
2173:
1593:
1587:
1582:
1557:
1553:
1547:
1514:
1508:
1464:
1460:
1408:
1404:
1334:
1330:
1295:
1286:
1277:
1268:
1206:
1191:
1171:inflammation
1168:
1156:
1118:
1052:
992:
948:
942:, including
924:
916:
912:
911:
834:
816:NP_001014358
813:
787:
769:NM_001014336
766:
742:
723:
697:
678:
652:
633:
613:
608:
444:hypothalamus
416:spermatocyte
348:
341:
307:123,627,552
294:123,618,220
206:122,174,221
193:122,172,029
68:External IDs
3716:Ustekinumab
3696:Briakinumab
3688:Antibodies:
3659:Fezakinumab
3656:Antibodies:
3620:Antibodies:
3608:Denenicokin
3583:Antibodies:
3520:Iboctadekin
3499:Vunakizumab
3494:Secukinumab
3484:Perakizumab
3471:Antibodies:
3379:Antibodies:
3336:Ustekinumab
3331:Briakinumab
3328:Antibodies:
3240:Antibodies:
3166:Tocilizumab
3136:Elsilimomab
3123:Antibodies:
3075:Mepolizumab
3067:Antibodies:
3021:Antibodies:
2948:Daniplestim
2917:Basiliximab
2914:Antibodies:
2882:Celmoleukin
2877:Aldesleukin
2841:Lutikizumab
2836:Gevokizumab
2831:Canakinumab
2828:Antibodies:
2547:IL17 family
2288:IL10 family
2207:IL12 family
2059:(grouped by
2047:Interleukin
1970:Lymphotoxin
1144:macrophages
1109:transcribed
993:IL-31 is a
46:Identifiers
4003:Categories
3771:B (IFN-λ3)
3767:A (IFN-λ2)
3701:Guselkumab
3691:Brazikumab
3586:Fletikumab
3489:Remtolumab
3479:Ixekizumab
3474:Brodalumab
3357:Binetrakin
3295:Oprelvekin
3264:Ilodecakin
3243:Enokizumab
3156:Siltuximab
3146:Olokizumab
3080:Reslizumab
3014:Pitrakinra
2994:Binetrakin
2963:Milodistim
2958:Leridistim
2927:Inolimomab
2902:Teceleukin
2821:Isunakinra
2758:modulators
2654:Lymphokine
2492:IL1B/IL1F2
2487:IL1A/IL1F1
2483:IL1 family
2347:Interferon
2335:IL29/IFNL1
1517:(4): 423.
1263:, May 2017
1242:, May 2017
1219:References
1213:Lokivetmab
1140:mast cells
352:(ortholog)
286:5|5 F
89:HomoloGene
3976:Unsorted:
3837:Agonists:
3816:Agonists:
3795:Agonists:
3755:Agonists:
3734:Agonists:
3678:Agonists:
3646:Agonists:
3605:Agonists:
3563:Agonists:
3535:Tadekinig
3517:Agonists:
3436:Agonists:
3410:Agonists:
3354:Agonists:
3313:Agonists:
3287:Agonists:
3261:Agonists:
3230:Agonists:
3189:Agonists:
3171:Levilimab
3161:Sirukumab
3151:Sarilumab
3108:Agonists:
3047:Agonists:
3024:Dupilumab
2991:Agonists:
2968:Muplestim
2945:Agonists:
2869:Agonists:
2796:Pifonakin
2791:Mobenakin
2774:Agonists:
2532:33/IL1F11
2497:1Ra/IL1F3
2144:IL6 like/
1861:CXCL8/IL8
1659:Chemokine
1651:By family
1644:cytokines
1063:monocytes
1049:Signaling
989:Structure
837:NP_083870
790:NM_029594
599:Orthologs
412:spermatid
97:GeneCards
3930:IL-22Rα1
3896:instead.
3213:instead.
3141:mAb 1339
3126:ARGX-109
3090:TPI ASM8
3060:YM-90709
2811:Anakinra
2806:AF-12198
2649:Monokine
2178:+non IL
2063:subunit)
2061:receptor
2032:TNFSF13B
1980:TNFC/LTB
1975:TNFB/LTA
1574:26198770
1539:21935134
1531:24510535
1491:18926762
1425:21982586
1359:12442845
1351:15184896
1259:–
1238:–
1193:Pruritic
1115:Function
1027:cysteine
995:cytokine
975:PI3K/AKT
885:Wikidata
578:Sources:
428:placenta
185:12q24.31
3948:IL-10Rβ
3944:IL-20Rα
3934:IL-20Rβ
3868:IL-36RA
3413:ALT-803
2537:18/IL1G
2279:Type II
2211:IL12RB1
2117:β chain
2071:γ chain
2027:TNFSF13
2022:TNFSF11
2017:TNFSF10
1699:/RANTES
1482:2659402
1261:Ensembl
1240:Ensembl
1202:neurons
1146:, and
959:IL-31RA
921:protein
919:) is a
711:UniProt
666:Ensembl
605:Species
584:QuickGO
327:pattern
85:1923649
53:Aliases
3904:Others
3877:Others
3829:IL1RL2
3808:IL1RL1
3545:IL18BP
2816:IL-1RA
2527:IL1F10
2424:IFNA21
2419:IFNA17
2414:IFNA16
2409:IFNA14
2404:IFNA13
2399:IFNA10
2056:Type I
2012:TNFSF9
2007:TNFSF8
2002:TNFSF7
1997:TNFSF6
1987:TNFSF4
1922:CX3CL1
1906:CXCL17
1901:CXCL16
1896:CXCL15
1891:CXCL14
1886:CXCL13
1881:CXCL12
1876:CXCL11
1871:CXCL10
1693:/MIP1β
1687:/MIP1α
1572:
1537:
1529:
1489:
1479:
1423:
1357:
1349:
1185:, and
1077:, and
1057:) and
1055:IL31RA
977:, and
871:search
869:PubMed
744:Q6EAL8
725:Q6EBC2
635:386653
621:Entrez
474:BioGPS
424:zygote
77:609509
3787:IL-31
3747:IL-28
3726:IL-27
3670:IL-23
3638:IL-22
3597:IL-21
3555:IL-20
3509:IL-18
3428:IL-17
3402:IL-15
3346:IL-13
3305:IL-12
3279:IL-11
3253:IL-10
2589:KITLG
2577:Other
2563:IL17A
2522:IL1F9
2517:IL1F8
2512:IL1F7
2507:IL1F6
2502:IL1F5
2439:IFNW1
2429:IFNB1
2394:IFNA8
2389:IFNA7
2384:IFNA6
2379:IFNA5
2374:IFNA4
2369:IFNA2
2364:IFNA1
2243:Other
2146:gp130
2135:GMCSF
1915:CX3CL
1866:CXCL9
1856:CXCL7
1851:CXCL6
1846:CXCL5
1841:CXCL4
1836:CXCL3
1831:CXCL2
1825:CXCL1
1809:CCL28
1804:CCL27
1799:CCL26
1794:CCL25
1789:CCL24
1784:CCL23
1779:CCL22
1774:CCL21
1769:CCL20
1764:CCL19
1758:CCL18
1753:CCL17
1748:CCL16
1743:CCL15
1738:CCL14
1733:CCL13
1728:CCL12
1723:CCL11
1681:/MCP1
1535:S2CID
1355:S2CID
1187:CCL22
1183:CCL17
1100:SHP-2
1079:STAT5
1075:STAT3
1071:STAT1
1031:WSxWS
1011:IL-27
1007:IL-11
917:IL-31
654:76399
614:Mouse
609:Human
580:Amigo
350:Mouse
343:Human
290:Start
225:Mouse
189:Start
122:Human
93:88541
18:IL-31
3894:here
3892:See
3222:IL-9
3211:here
3202:IL-8
3181:IL-7
3100:IL-6
3039:IL-5
2983:IL-4
2937:IL-3
2861:IL-2
2766:IL-1
2709:IL13
2704:IL10
2673:TNFβ
2668:IFNγ
2640:TNFA
2621:cell
2601:SPP1
2559:IL25
2555:IL17
2457:IFNG
2434:IFNK
2320:IL26
2315:IL24
2310:IL20
2305:IL19
2300:IL22
2296:IL10
2265:IL34
2260:IL32
2255:IL16
2250:IL14
2234:IL35
2229:IL27
2224:IL23
2219:IL12
2195:CTF1
2190:CNTF
2174:IL31
2169:IL30
2164:IL27
2159:IL11
2107:IL21
2092:IL13
2083:IL15
1965:TNFA
1943:XCL2
1938:XCL1
1818:CXCL
1718:CCL9
1713:CCL8
1708:CCL7
1703:CCL6
1697:CCL5
1691:CCL4
1685:CCL3
1679:CCL2
1674:CCL1
1592:In:
1570:PMID
1527:PMID
1487:PMID
1421:PMID
1347:PMID
1179:CCL1
1092:PI3K
1087:JAK2
1085:and
1083:JAK1
1043:OSMR
1041:and
1003:IL-6
979:JAK1
961:and
928:gene
925:IL31
333:Bgee
281:Band
242:Chr.
180:Band
139:Chr.
101:IL31
73:OMIM
60:IL31
37:IL31
3920:CD4
3885:JAK
2699:IL6
2694:IL5
2689:IL4
2635:IL1
2606:MIF
2185:LIF
2180:OSM
2154:IL6
2130:IL5
2125:IL3
2102:IL9
2097:IL7
2088:IL4
2079:IL2
2037:EDA
1957:TNF
1931:XCL
1827:/KC
1667:CCL
1598:doi
1562:doi
1519:doi
1477:PMC
1469:doi
1413:doi
1339:doi
1125:CD4
1104:Shc
1017:),
1015:LIF
482:n/a
303:End
202:End
105:OMA
81:MGI
4005::
3850:,
3846:,
3769:,
3461:,
3457:,
3453:,
3449:,
3445:,
2783:,
2485::
2449:II
1642::
1568:.
1558:26
1556:.
1533:.
1525:.
1515:14
1513:.
1499:^
1485:.
1475:.
1465:19
1463:.
1459:.
1433:^
1419:.
1409:91
1407:.
1367:^
1353:.
1345:.
1333:.
1321:^
1304:^
1294:.
1276:.
1247:^
1226:^
1207:A
1181:,
1142:,
1138:,
1111:.
1073:,
1009:,
1005:,
973:,
946:.
582:/
309:bp
296:bp
208:bp
195:bp
103:;
99::
95:;
91::
87:;
83::
79:;
75::
3965:)
3946:/
3932:/
3922:)
3854:)
3852:γ
3848:β
3844:α
3842:(
3773:)
3765:(
3465:)
3463:F
3455:D
3451:C
3447:B
3443:A
3441:(
2787:)
2785:β
2781:α
2779:(
2747:e
2740:t
2733:v
2684:2
2682:h
2680:T
2663:1
2661:h
2659:T
2565:)
2561:(
2557:/
2356:I
2298:/
2209:/
2090:/
2081:/
1632:e
1625:t
1618:v
1600::
1576:.
1564::
1541:.
1521::
1493:.
1471::
1427:.
1415::
1361:.
1341::
1335:5
1315:.
1298:.
1280:.
1134:H
1132:T
983:2
981:/
955:2
953:H
951:T
915:(
227:)
124:)
107::
31:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
