253:
230:
127:
152:
259:
158:
2154:
Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van
Eerdewegh P, Bradley WE, Croteau P, Nguyen-Huu Q, Segal J, Debrus S, Allard R, Rosenstiel P, Franke A, Jacobs G, Nikolaus S, Vidal JM, Szego P, Laplante N, Clark HF, Paulussen RJ, Hooper JW, Keith TP, Belouchi A, Schreiber S (Sep 2007).
1145:
activation. There is also a variant of IL-23R that consists of just the extracellular part and is known as soluble IL-23R. This form can compete with the membrane-bound form to bind IL-23, modulating the Th17 immune response and regulation of inflammation and immune function.
1748:
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH (Dec 2006).
2009:
Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Devoto M, Grant SF, Hakonarson H (Aug 2007).
1887:
Tremelling M, Cummings F, Fisher SA, Mansfield J, Gwilliam R, Keniry A, Nimmo ER, Drummond H, Onnie CM, Prescott NJ, Sanderson J, Bredin F, Berzuini C, Forbes A, Lewis CM, Cardon L, Deloukas P, Jewell D, Mathew CG, Parkes M, Satsangi J (May 2007).
1800:
Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB (Feb 2007).
1674:
Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal
Malefyt R, Moore KW (Jun 2002).
1710:
Zhang XY, Zhang HJ, Zhang Y, Fu YJ, He J, Zhu LP, Wang SH, Liu L (Jan 2006). "Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells".
3300:
2875:
1635:
de Paus RA, van de
Wetering D, van Dissel JT, van de Vosse E (September 2008). "IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants".
2117:
Oliver J, Rueda B, López-Nevot MA, Gómez-García M, Martín J (Aug 2007). "Replication of an association between IL23R gene polymorphism with inflammatory bowel disease".
266:
165:
2998:
1844:
Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI (May 2007).
3293:
2285:
1118:
mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a
833:
814:
1162:), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. This protein associates constitutively with Janus kinase 2 (
88:
2675:
3286:
3246:
2964:
2960:
2943:
1107:
4498:
3765:
3077:
3052:
2916:
1347:"Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen-activated leukocytes"
1266:
1248:
4502:
4488:
4448:
3081:
3056:
2907:
4563:
4517:
3234:
2933:
2868:
2088:
Orozco G, Rueda B, Robledo G, García A, Martín J (Aug 2007). "Investigation of the IL23R gene in a
Spanish rheumatoid arthritis cohort".
2928:
252:
4568:
4422:
1033:
3370:
1580:"Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease"
1040:
1287:
229:
2807:
2512:
2504:
2278:
2202:"Interleukin-23R Arg381Gln is associated with susceptibility to Crohn's disease but not with phenotype in an Italian population"
3155:
2453:
2157:"Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci"
1235:
1214:
3150:
3098:
2489:
1138:
1231:
151:
126:
4383:
4362:
2402:
2364:
2359:
1677:"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R"
1306:"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R"
1803:"A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes"
1210:
2407:
1190:. The effect of IL-23R variations present in the population have been studied with an in vitro expression model system.
68:
3119:
3115:
2271:
1976:"Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients"
1126:
2820:
265:
164:
2053:
Sánchez E, Rueda B, Callejas JL, Sabio JM, Ortego-Centeno N, Jimenez-Alonso J, López-Nevot MA, Martín J (Sep 2007).
3135:
2751:
2307:
1931:
Cummings JR, Ahmad T, Geremia A, Beckly J, Cooney R, Hancock L, Pathan S, Guo C, Cardon LR, Jewell DP (Sep 2007).
258:
157:
3111:
3035:
2734:
2520:
1531:"Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease"
1388:"The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species"
3265:
3229:
2760:
1097:
878:
76:
2012:"Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease"
4341:
4301:
4280:
4192:
4151:
4109:
4063:
3982:
3956:
3900:
3859:
3833:
3807:
3461:
3184:
3162:
3086:
3073:
3060:
3048:
3016:
3003:
2993:
2956:
2912:
2903:
2830:
2803:
2794:
2389:
2200:
Borgiani P, Perricone C, Ciccacci C, Romano S, Novelli G, Biancone L, Petruzziello C, Pallone F (Sep 2007).
859:
3916:
3776:
3756:
3735:
3654:
3593:
3537:
3491:
3415:
3320:
3221:
3145:
2898:
2864:
2855:
2825:
2816:
2799:
2397:
2317:
1933:"Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype"
2923:
1445:
3426:
1129:
and an intracellular part that contains three potential tyrosine phosphorylation domains. There are 24
4538:
4321:
3309:
3043:
2951:
2893:
2850:
2777:
1762:
1485:
140:
55:
3451:
1141:
in the region encoding the domain that binds IL-23, which may lead to differences between people in
4312:
3870:
3665:
3441:
3335:
3260:
3255:
3093:
1890:"IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease"
4182:
4177:
4162:
4074:
4053:
3502:
3436:
3395:
3339:
3312:
3250:
3021:
2769:
2302:
1962:
1736:
1617:
1187:
100:
4043:
3911:
3818:
3797:
3548:
3517:
3512:
3456:
3375:
2055:"Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus"
1183:
1016:
995:
969:
948:
4089:
3522:
3350:
3345:
3695:
3680:
3644:
3614:
3360:
2294:
2243:
2223:
2188:
2142:
2105:
2076:
2041:
1997:
1954:
1919:
1875:
1832:
1788:
1728:
1698:
1652:
1609:
1560:
1511:
1409:
1368:
1327:
48:
4533:
3209:
3012:
2885:
2726:
2718:
2619:
2611:
2603:
2595:
2213:
2178:
2168:
2134:
2126:
2097:
2066:
2031:
2023:
1987:
1944:
1909:
1901:
1865:
1857:
1822:
1814:
1778:
1770:
1720:
1688:
1644:
1599:
1591:
1578:
Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, et al. (Jan 2011).
1550:
1542:
1501:
1493:
1431:
1399:
1358:
1317:
1142:
345:
276:
220:
175:
4009:
4005:
4001:
96:
4325:
2635:
1458:
320:
1472:
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. (Dec 2006).
1766:
1751:"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene"
1489:
1474:"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene"
1304:
Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002).
4523:
4513:
4508:
4494:
4480:
4470:
4465:
4412:
4394:
4373:
4352:
4331:
4317:
4291:
4235:
4203:
4167:
4130:
4125:
4120:
4084:
4079:
3993:
3972:
3926:
3875:
3844:
3823:
3558:
3527:
2536:
2183:
2156:
2036:
2011:
1914:
1889:
1870:
1845:
1827:
1802:
1783:
1750:
1555:
1530:
1529:
Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, et al. (Nov 2011).
1506:
1473:
1155:
1119:
1111:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
602:
597:
592:
587:
582:
577:
561:
556:
551:
546:
541:
536:
4557:
4265:
3921:
3787:
3746:
3670:
3604:
3553:
3507:
3446:
3331:
2988:
2782:
2252:
2071:
2054:
523:
1966:
1740:
1621:
80:
4439:
4260:
3946:
3941:
3936:
3685:
3624:
3583:
3176:
2544:
1428:"Figure 8. with two source data miR-34a regulates Th17 cell-mediated proliferation"
338:
117:
3278:
684:
positive regulation of granulocyte macrophage colony-stimulating factor production
2218:
2201:
2101:
1905:
1693:
1676:
1648:
1322:
1305:
104:
4270:
4250:
4213:
4048:
4038:
3890:
3885:
3720:
3690:
3629:
3471:
3431:
3390:
3385:
2369:
2344:
1271:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1253:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2161:
Proceedings of the
National Academy of Sciences of the United States of America
421:
4255:
4245:
4140:
4033:
4028:
3849:
3710:
3700:
3634:
3568:
3481:
3476:
3405:
2130:
2027:
1992:
1975:
1724:
1579:
1123:
237:
134:
84:
1404:
1387:
3725:
3715:
3705:
3578:
2659:
2651:
2643:
2173:
1774:
1497:
1436:
1427:
778:
481:
359:
304:
291:
203:
190:
92:
2227:
2192:
2146:
2109:
2080:
2045:
2001:
1958:
1923:
1879:
1836:
1792:
1732:
1702:
1656:
1613:
1604:
1564:
1515:
1413:
1372:
1331:
1080:
1075:
3365:
2699:
2691:
2683:
2667:
1846:"IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease"
1363:
1346:
1064:
923:
904:
4484:
3967:
3068:
3064:
2811:
2257:
2247:
2138:
1159:
890:
845:
1949:
1932:
1861:
4099:
3204:
3199:
3194:
3189:
3166:
3106:
3102:
2842:
2475:
2263:
1974:
Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A (2007).
1048:
800:
17:
1818:
1595:
1546:
4406:
4402:
4398:
4017:
4013:
3997:
3239:
2859:
2790:
2786:
2576:
2528:
2470:
2434:
2429:
2424:
2419:
2414:
2379:
2339:
2329:
1167:
1154:
The protein encoded by this gene is a subunit of the receptor for
763:
759:
2627:
2568:
2560:
2552:
2463:
2374:
2354:
2349:
2334:
2325:
1163:
72:
3282:
2267:
739:
positive regulation of tyrosine phosphorylation of STAT protein
4474:
1106:
gene. In complex with the interleukin-12 receptor β1 subunit (
2242:
Overview of all the structural information available in the
1158:. This protein pairs with the receptor molecule IL-12Rβ1 (
729:
positive regulation of activation of Janus kinase activity
654:
positive regulation of T-helper 17 cell lineage commitment
724:
positive regulation of defense response to virus by host
664:
positive regulation of natural killer cell proliferation
328:
674:
positive regulation of T-helper 17 type immune response
734:
regulation of tyrosine phosphorylation of STAT protein
679:
positive regulation of T-helper 1 type immune response
719:
positive regulation of activated T cell proliferation
493:
699:
positive regulation of memory T cell differentiation
4458:
4438:
4431:
4382:
4361:
4340:
4300:
4279:
4223:
4191:
4150:
4108:
4062:
3981:
3955:
3899:
3858:
3832:
3806:
3775:
3755:
3734:
3653:
3592:
3536:
3490:
3414:
3319:
3220:
3175:
3134:
3034:
2980:
2942:
2884:
2841:
2768:
2759:
2750:
2711:
2588:
2497:
2488:
2443:
2388:
2316:
2301:
1009:
988:
962:
941:
639:
positive regulation of T cell mediated cytotoxicity
1227:
1225:
1223:
1206:
1204:
1202:
1133:splice variants in mitogen-activated lymphocytes.
644:positive regulation of interferon-gamma production
1386:Yu RY, Brazaitis J, Gallagher G (February 2015).
649:positive regulation of osteoclast differentiation
275:
174:
704:positive regulation of interleukin-17 production
629:positive regulation of interleukin-12 production
619:negative regulation of interleukin-10 production
1345:Kan SH, Mancini G, Gallagher G (October 2008).
27:Protein-coding gene in the species Homo sapiens
1299:
1297:
1232:GRCm38: Ensembl release 89: ENSMUSG00000049093
3294:
2279:
8:
1288:"Entrez Gene: IL23R interleukin 23 receptor"
1166:) and also binds to transcription activator
1211:GRCh38: Ensembl release 89: ENSG00000162594
694:positive regulation of T cell proliferation
689:defense response to Gram-negative bacterium
659:positive regulation of NK T cell activation
4435:
3301:
3287:
3279:
2765:
2756:
2494:
2313:
2286:
2272:
2264:
774:
519:
316:
215:
112:
2217:
2182:
2172:
2070:
2035:
1991:
1948:
1913:
1869:
1826:
1782:
1692:
1603:
1554:
1505:
1435:
1403:
1362:
1321:
749:interleukin-23-mediated signaling pathway
4466:Interleukin 14 (taxilin alpha, HMW-BCGF)
2119:Clinical Gastroenterology and Hepatology
2016:Clinical Gastroenterology and Hepatology
1282:
1280:
1182:gene have been shown to protect against
1198:
3764:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1454:
1443:
29:
280:
241:
236:
179:
138:
133:
7:
2212:(3): 1049–51, author reply 1051–2.
1110:), it is activated by the cytokine
744:cytokine-mediated signaling pathway
1807:American Journal of Human Genetics
1006:
985:
959:
938:
914:
895:
869:
850:
824:
805:
498:
416:
354:
333:
25:
2256:(Interleukin-23 receptor) at the
2072:10.1111/j.1399-0039.2007.00881.x
1100:. It is encoded in human by the
603:external side of plasma membrane
537:interleukin-23 receptor activity
264:
257:
251:
228:
163:
156:
150:
125:
4292:Interleukin 27 (interleukin 30)
1139:single-nucleotide polymorphisms
583:interleukin-23 receptor complex
542:interleukin-12 receptor binding
1170:in a ligand-dependent manner.
669:response to lipopolysaccharide
578:integral component of membrane
482:More reference expression data
1:
249:
148:
2219:10.1053/j.gastro.2007.07.013
2102:10.1016/j.humimm.2007.05.008
1906:10.1053/j.gastro.2007.02.051
1694:10.4049/jimmunol.168.11.5699
1649:10.1016/j.molimm.2008.06.029
1323:10.4049/jimmunol.168.11.5699
624:response to interferon-gamma
4564:Genes on human chromosome 1
3642:Antisense oligonucleotides:
1937:Inflammatory Bowel Diseases
1850:Inflammatory Bowel Diseases
1127:fibronectin III-like domain
4585:
557:cytokine receptor activity
4569:Type I cytokine receptors
2131:10.1016/j.cgh.2007.05.002
2028:10.1016/j.cgh.2007.04.024
1993:10.1007/s10038-007-0156-z
1980:Journal of Human Genetics
1725:10.1007/s00251-005-0067-0
1267:"Mouse PubMed Reference:"
1249:"Human PubMed Reference:"
1079:
1074:
1070:
1063:
1047:
1028:
1013:
992:
981:
966:
945:
934:
921:
917:
902:
898:
889:
876:
872:
857:
853:
844:
831:
827:
812:
808:
799:
784:
777:
773:
757:
522:
518:
506:
501:
492:
479:
428:
419:
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
59:, interleukin 23 receptor
53:
46:
41:
37:
32:
1405:10.4049/jimmunol.1401850
1098:type I cytokine receptor
4332:Interleukin-29 (IFN-λ1)
3477:Daclizumab (dacliximab)
3462:Tucotuzumab celmoleukin
2174:10.1073/pnas.0706645104
2125:(8): 977–81, 981.e1–2.
1775:10.1126/science.1135245
1498:10.1126/science.1135245
1437:10.7554/elife.39479.025
1094:interleukin-23 receptor
1034:Chr 1: 67.14 – 67.26 Mb
4313:Interferon λ4 (IFN-λ4)
3406:Rilonacept (IL-1 Trap)
3222:Enzyme-linked receptor
1453:Cite journal requires
1178:Three variants in the
1041:Chr 6: 67.4 – 67.47 Mb
709:innate immune response
552:interleukin-23 binding
4236:Interleukin 23 (SGRF)
3917:Cintredekin besudotox
3845:Interleukin 11 (AGIF)
3824:Interleukin 10 (CSIF)
3044:Interleukin receptors
2952:Interleukin receptors
2894:Interleukin receptors
2851:Interleukin receptors
2778:Interleukin receptors
1681:Journal of Immunology
1392:Journal of Immunology
1310:Journal of Immunology
1174:Clinical significance
714:inflammatory response
634:immune system process
3310:Interleukin receptor
3094:Interferon receptors
1637:Molecular Immunology
1364:10.1038/gene.2008.64
402:right adrenal cortex
243:Chromosome 6 (mouse)
141:Chromosome 1 (human)
3442:Denileukin diftitox
1767:2006Sci...314.1461D
1490:2006Sci...314.1461D
398:right adrenal gland
390:epithelium of colon
382:islet of Langerhans
4014:E (interleukin 25)
2303:Chemokine receptor
2295:Cytokine receptors
1351:Genes and Immunity
1188:ulcerative colitis
879:ENSMUSG00000049093
612:Biological process
571:Cellular component
530:Molecular function
406:left adrenal gland
4551:
4550:
4547:
4546:
4516:(signals through
4497:(signals through
4483:(signals through
4473:(signals through
4097:Binding proteins:
3427:Adargileukin alfa
3276:
3275:
3130:
3129:
3030:
3029:
2746:
2745:
2484:
2483:
1950:10.1002/ibd.20180
1862:10.1002/ibd.20126
1090:
1089:
1086:
1085:
1059:
1058:
1024:
1023:
1003:
1002:
977:
976:
956:
955:
930:
929:
911:
910:
885:
884:
866:
865:
840:
839:
821:
820:
769:
768:
514:
513:
510:
509:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
105:IL23R - orthologs
16:(Redirected from
4576:
4539:Efineptakin alfa
4534:Efavaleukin alfa
4436:
3403:Decoy receptors:
3303:
3296:
3289:
3280:
3013:hormone receptor
2766:
2757:
2495:
2314:
2288:
2281:
2274:
2265:
2231:
2221:
2206:Gastroenterology
2196:
2186:
2176:
2167:(37): 14747–52.
2150:
2113:
2090:Human Immunology
2084:
2074:
2049:
2039:
2005:
1995:
1970:
1952:
1927:
1917:
1894:Gastroenterology
1883:
1873:
1840:
1830:
1796:
1786:
1761:(5804): 1461–3.
1744:
1706:
1696:
1687:(11): 5699–708.
1661:
1660:
1632:
1626:
1625:
1607:
1575:
1569:
1568:
1558:
1526:
1520:
1519:
1509:
1484:(5804): 1461–3.
1469:
1463:
1462:
1456:
1451:
1449:
1441:
1439:
1424:
1418:
1417:
1407:
1383:
1377:
1376:
1366:
1342:
1336:
1335:
1325:
1316:(11): 5699–708.
1301:
1292:
1291:
1284:
1275:
1274:
1263:
1257:
1256:
1245:
1239:
1229:
1218:
1208:
1072:
1071:
1043:
1036:
1019:
1007:
998:
986:
982:RefSeq (protein)
972:
960:
951:
939:
915:
896:
870:
851:
825:
806:
775:
593:receptor complex
562:cytokine binding
520:
499:
484:
436:secondary oocyte
424:
422:Top expressed in
417:
370:secondary oocyte
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
4584:
4583:
4579:
4578:
4577:
4575:
4574:
4573:
4554:
4553:
4552:
4543:
4454:
4427:
4378:
4357:
4336:
4296:
4275:
4219:
4216:(against IL-22)
4187:
4146:
4143:(against IL-20)
4104:
4058:
3977:
3951:
3895:
3854:
3828:
3802:
3771:
3751:
3730:
3649:
3588:
3532:
3486:
3410:
3315:
3307:
3277:
3272:
3216:
3171:
3126:
3026:
2976:
2938:
2880:
2837:
2742:
2707:
2636:Osteoprotegerin
2584:
2480:
2439:
2384:
2305:
2297:
2292:
2239:
2234:
2199:
2153:
2116:
2087:
2059:Tissue Antigens
2052:
2008:
1973:
1930:
1886:
1843:
1799:
1747:
1709:
1673:
1669:
1667:Further reading
1664:
1643:(15): 3889–95.
1634:
1633:
1629:
1605:1854/LU-1145381
1584:Nature Genetics
1577:
1576:
1572:
1541:(11): 1066–73.
1535:Nature Genetics
1528:
1527:
1523:
1471:
1470:
1466:
1452:
1442:
1426:
1425:
1421:
1385:
1384:
1380:
1344:
1343:
1339:
1303:
1302:
1295:
1286:
1285:
1278:
1265:
1264:
1260:
1247:
1246:
1242:
1230:
1221:
1209:
1200:
1196:
1184:Crohn's disease
1176:
1152:
1081:View/Edit Mouse
1076:View/Edit Human
1039:
1032:
1029:Location (UCSC)
1015:
994:
968:
947:
860:ENSG00000162594
753:
607:
598:plasma membrane
566:
547:protein binding
480:
471:
466:
462:
458:
454:
450:
446:
442:
438:
434:
420:
409:
404:
400:
396:
392:
388:
384:
380:
376:
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
4582:
4580:
4572:
4571:
4566:
4556:
4555:
4549:
4548:
4545:
4544:
4542:
4541:
4536:
4527:
4526:
4524:Interleukin 35
4521:
4514:Interleukin 34
4511:
4509:Interleukin 32
4506:
4495:Interleukin 26
4492:
4481:Interleukin 24
4478:
4471:Interleukin 16
4468:
4462:
4460:
4456:
4455:
4453:
4452:
4444:
4442:
4433:
4429:
4428:
4426:
4425:
4416:
4415:
4413:Interleukin 38
4410:
4395:Interleukin 36
4388:
4386:
4380:
4379:
4377:
4376:
4374:Interleukin 33
4367:
4365:
4359:
4358:
4356:
4355:
4353:Interleukin 31
4346:
4344:
4338:
4337:
4335:
4334:
4329:
4318:Interleukin 28
4315:
4306:
4304:
4298:
4297:
4295:
4294:
4285:
4283:
4277:
4276:
4274:
4273:
4268:
4263:
4258:
4253:
4248:
4239:
4238:
4229:
4227:
4221:
4220:
4218:
4217:
4207:
4206:
4204:Interleukin 22
4197:
4195:
4189:
4188:
4186:
4185:
4180:
4171:
4170:
4168:Interleukin 21
4165:
4156:
4154:
4148:
4147:
4145:
4144:
4134:
4133:
4131:Interleukin 24
4128:
4126:Interleukin 20
4123:
4121:Interleukin 19
4114:
4112:
4106:
4105:
4103:
4102:
4093:
4092:
4087:
4085:Interleukin 37
4082:
4080:Interleukin 18
4077:
4068:
4066:
4060:
4059:
4057:
4056:
4051:
4046:
4041:
4036:
4031:
4022:
4021:
3994:Interleukin 17
3987:
3985:
3979:
3978:
3976:
3975:
3973:Interleukin 15
3970:
3961:
3959:
3953:
3952:
3950:
3949:
3944:
3939:
3930:
3929:
3927:Interleukin 13
3924:
3919:
3914:
3905:
3903:
3897:
3896:
3894:
3893:
3888:
3879:
3878:
3876:Interleukin 12
3873:
3864:
3862:
3856:
3855:
3853:
3852:
3847:
3838:
3836:
3830:
3829:
3827:
3826:
3821:
3812:
3810:
3804:
3803:
3801:
3800:
3791:
3790:
3781:
3779:
3773:
3772:
3770:
3769:
3761:
3759:
3753:
3752:
3750:
3749:
3740:
3738:
3732:
3731:
3729:
3728:
3723:
3718:
3713:
3708:
3703:
3698:
3693:
3688:
3683:
3674:
3673:
3668:
3659:
3657:
3651:
3650:
3648:
3647:
3638:
3637:
3632:
3627:
3618:
3617:
3608:
3607:
3598:
3596:
3590:
3589:
3587:
3586:
3581:
3572:
3571:
3562:
3561:
3559:Interleukin 13
3556:
3551:
3542:
3540:
3534:
3533:
3531:
3530:
3528:Promegapoietin
3525:
3520:
3515:
3510:
3505:
3496:
3494:
3488:
3487:
3485:
3484:
3479:
3474:
3465:
3464:
3459:
3454:
3452:Pegaldesleukin
3449:
3444:
3439:
3434:
3429:
3420:
3418:
3412:
3411:
3409:
3408:
3399:
3398:
3393:
3388:
3379:
3378:
3373:
3368:
3363:
3354:
3353:
3348:
3343:
3325:
3323:
3317:
3316:
3308:
3306:
3305:
3298:
3291:
3283:
3274:
3273:
3271:
3270:
3269:
3268:
3263:
3258:
3244:
3243:
3242:
3237:
3226:
3224:
3218:
3217:
3215:
3214:
3213:
3212:
3207:
3202:
3197:
3192:
3181:
3179:
3173:
3172:
3170:
3169:
3160:
3159:
3158:
3153:
3143:
3140:
3138:
3136:Ig superfamily
3132:
3131:
3128:
3127:
3125:
3124:
3123:
3122:
3109:
3091:
3090:
3089:
3084:
3071:
3040:
3038:
3032:
3031:
3028:
3027:
3025:
3024:
3019:
3009:
3008:
3007:
3006:
3004:Thrombopoietin
3001:
2996:
2984:
2982:
2978:
2977:
2975:
2974:
2973:
2972:
2967:
2948:
2946:
2940:
2939:
2937:
2936:
2931:
2926:
2921:
2920:
2919:
2910:
2901:
2890:
2888:
2882:
2881:
2879:
2878:
2873:
2872:
2871:
2862:
2847:
2845:
2839:
2838:
2836:
2835:
2834:
2833:
2828:
2823:
2814:
2797:
2774:
2772:
2763:
2754:
2748:
2747:
2744:
2743:
2741:
2740:
2732:
2724:
2715:
2713:
2709:
2708:
2706:
2705:
2697:
2689:
2681:
2673:
2665:
2657:
2649:
2641:
2633:
2625:
2617:
2609:
2601:
2592:
2590:
2586:
2585:
2583:
2582:
2574:
2566:
2558:
2550:
2542:
2534:
2526:
2518:
2510:
2501:
2499:
2492:
2486:
2485:
2482:
2481:
2479:
2478:
2473:
2468:
2467:
2466:
2458:
2457:
2456:
2447:
2445:
2441:
2440:
2438:
2437:
2432:
2427:
2422:
2417:
2412:
2411:
2410:
2405:
2394:
2392:
2386:
2385:
2383:
2382:
2377:
2372:
2367:
2362:
2357:
2352:
2347:
2342:
2337:
2332:
2322:
2320:
2311:
2299:
2298:
2293:
2291:
2290:
2283:
2276:
2268:
2262:
2261:
2238:
2237:External links
2235:
2233:
2232:
2197:
2151:
2114:
2085:
2050:
2006:
1971:
1928:
1900:(5): 1657–64.
1884:
1841:
1819:10.1086/511051
1797:
1745:
1719:(12): 934–43.
1713:Immunogenetics
1707:
1670:
1668:
1665:
1663:
1662:
1627:
1596:10.1038/ng.733
1570:
1547:10.1038/ng.952
1521:
1464:
1455:|journal=
1419:
1378:
1337:
1293:
1276:
1258:
1240:
1219:
1197:
1195:
1192:
1175:
1172:
1151:
1148:
1137:includes some
1120:signal peptide
1112:interleukin 23
1088:
1087:
1084:
1083:
1078:
1068:
1067:
1061:
1060:
1057:
1056:
1054:
1052:
1045:
1044:
1037:
1030:
1026:
1025:
1022:
1021:
1011:
1010:
1004:
1001:
1000:
990:
989:
983:
979:
978:
975:
974:
964:
963:
957:
954:
953:
943:
942:
936:
932:
931:
928:
927:
919:
918:
912:
909:
908:
900:
899:
893:
887:
886:
883:
882:
874:
873:
867:
864:
863:
855:
854:
848:
842:
841:
838:
837:
829:
828:
822:
819:
818:
810:
809:
803:
797:
796:
791:
786:
782:
781:
771:
770:
767:
766:
755:
754:
752:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
615:
613:
609:
608:
606:
605:
600:
595:
590:
585:
580:
574:
572:
568:
567:
565:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
504:
503:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
440:primary oocyte
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
374:amniotic fluid
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4581:
4570:
4567:
4565:
4562:
4561:
4559:
4540:
4537:
4535:
4532:
4529:
4528:
4525:
4522:
4519:
4515:
4512:
4510:
4507:
4504:
4500:
4496:
4493:
4490:
4486:
4482:
4479:
4476:
4472:
4469:
4467:
4464:
4463:
4461:
4457:
4450:
4446:
4445:
4443:
4441:
4437:
4434:
4430:
4424:
4421:
4418:
4417:
4414:
4411:
4408:
4404:
4400:
4396:
4393:
4390:
4389:
4387:
4385:
4381:
4375:
4372:
4369:
4368:
4366:
4364:
4360:
4354:
4351:
4348:
4347:
4345:
4343:
4339:
4333:
4330:
4327:
4323:
4319:
4316:
4314:
4311:
4308:
4307:
4305:
4303:
4299:
4293:
4290:
4287:
4286:
4284:
4282:
4278:
4272:
4269:
4267:
4266:Tildrakizumab
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4241:
4240:
4237:
4234:
4231:
4230:
4228:
4226:
4222:
4215:
4212:
4209:
4208:
4205:
4202:
4199:
4198:
4196:
4194:
4190:
4184:
4181:
4179:
4176:
4173:
4172:
4169:
4166:
4164:
4161:
4158:
4157:
4155:
4153:
4149:
4142:
4139:
4136:
4135:
4132:
4129:
4127:
4124:
4122:
4119:
4116:
4115:
4113:
4111:
4107:
4101:
4098:
4095:
4094:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4070:
4069:
4067:
4065:
4061:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4024:
4023:
4019:
4015:
4011:
4007:
4003:
3999:
3995:
3992:
3989:
3988:
3986:
3984:
3980:
3974:
3971:
3969:
3966:
3963:
3962:
3960:
3958:
3954:
3948:
3945:
3943:
3940:
3938:
3935:
3932:
3931:
3928:
3925:
3923:
3922:Interleukin 4
3920:
3918:
3915:
3913:
3910:
3907:
3906:
3904:
3902:
3898:
3892:
3889:
3887:
3884:
3881:
3880:
3877:
3874:
3872:
3871:Edodekin alfa
3869:
3866:
3865:
3863:
3861:
3857:
3851:
3848:
3846:
3843:
3840:
3839:
3837:
3835:
3831:
3825:
3822:
3820:
3817:
3814:
3813:
3811:
3809:
3805:
3799:
3796:
3793:
3792:
3789:
3788:Interleukin 9
3786:
3783:
3782:
3780:
3778:
3774:
3767:
3763:
3762:
3760:
3758:
3754:
3748:
3747:Interleukin 7
3745:
3742:
3741:
3739:
3737:
3733:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3676:
3675:
3672:
3671:Interleukin 6
3669:
3667:
3666:Atexakin alfa
3664:
3661:
3660:
3658:
3656:
3652:
3646:
3643:
3640:
3639:
3636:
3633:
3631:
3628:
3626:
3623:
3620:
3619:
3616:
3613:
3610:
3609:
3606:
3605:Interleukin 5
3603:
3600:
3599:
3597:
3595:
3591:
3585:
3582:
3580:
3577:
3574:
3573:
3570:
3567:
3564:
3563:
3560:
3557:
3555:
3554:Interleukin 4
3552:
3550:
3547:
3544:
3543:
3541:
3539:
3535:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3508:Interleukin 3
3506:
3504:
3501:
3498:
3497:
3495:
3493:
3489:
3483:
3480:
3478:
3475:
3473:
3470:
3467:
3466:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3447:Interleukin 2
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3422:
3421:
3419:
3417:
3413:
3407:
3404:
3401:
3400:
3397:
3394:
3392:
3389:
3387:
3384:
3381:
3380:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3356:
3355:
3352:
3349:
3347:
3344:
3341:
3337:
3333:
3332:Interleukin 1
3330:
3327:
3326:
3324:
3322:
3318:
3314:
3311:
3304:
3299:
3297:
3292:
3290:
3285:
3284:
3281:
3267:
3264:
3262:
3259:
3257:
3254:
3253:
3252:
3248:
3245:
3241:
3238:
3236:
3233:
3232:
3231:
3228:
3227:
3225:
3223:
3219:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3187:
3186:
3183:
3182:
3180:
3178:
3174:
3168:
3164:
3161:
3157:
3154:
3152:
3149:
3148:
3147:
3144:
3142:
3141:
3139:
3137:
3133:
3121:
3117:
3113:
3110:
3108:
3104:
3100:
3097:
3096:
3095:
3092:
3088:
3085:
3083:
3079:
3075:
3072:
3070:
3066:
3062:
3058:
3054:
3050:
3047:
3046:
3045:
3042:
3041:
3039:
3037:
3033:
3023:
3020:
3018:
3014:
3011:
3010:
3005:
3002:
3000:
2997:
2995:
2992:
2991:
2990:
2989:CSF receptors
2986:
2985:
2983:
2979:
2971:
2968:
2966:
2962:
2958:
2955:
2954:
2953:
2950:
2949:
2947:
2945:
2941:
2935:
2932:
2930:
2927:
2925:
2922:
2918:
2914:
2911:
2909:
2905:
2902:
2900:
2897:
2896:
2895:
2892:
2891:
2889:
2887:
2883:
2877:
2874:
2870:
2866:
2863:
2861:
2857:
2854:
2853:
2852:
2849:
2848:
2846:
2844:
2840:
2832:
2829:
2827:
2824:
2822:
2818:
2815:
2813:
2809:
2805:
2801:
2798:
2796:
2792:
2788:
2784:
2781:
2780:
2779:
2776:
2775:
2773:
2771:
2767:
2764:
2762:
2758:
2755:
2753:
2749:
2739:
2736:
2733:
2731:
2728:
2725:
2723:
2720:
2717:
2716:
2714:
2710:
2704:
2701:
2698:
2696:
2693:
2690:
2688:
2685:
2682:
2680:
2677:
2674:
2672:
2669:
2666:
2664:
2661:
2658:
2656:
2653:
2650:
2648:
2645:
2642:
2640:
2637:
2634:
2632:
2629:
2626:
2624:
2621:
2618:
2616:
2613:
2610:
2608:
2605:
2602:
2600:
2597:
2594:
2593:
2591:
2587:
2581:
2578:
2575:
2573:
2570:
2567:
2565:
2562:
2559:
2557:
2554:
2551:
2549:
2546:
2543:
2541:
2538:
2535:
2533:
2530:
2527:
2525:
2522:
2519:
2517:
2514:
2511:
2509:
2506:
2503:
2502:
2500:
2496:
2493:
2491:
2487:
2477:
2474:
2472:
2469:
2465:
2462:
2461:
2459:
2455:
2452:
2451:
2449:
2448:
2446:
2442:
2436:
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2416:
2413:
2409:
2406:
2404:
2401:
2400:
2399:
2396:
2395:
2393:
2391:
2387:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2327:
2324:
2323:
2321:
2319:
2315:
2312:
2309:
2304:
2300:
2296:
2289:
2284:
2282:
2277:
2275:
2270:
2269:
2266:
2259:
2255:
2254:
2249:
2245:
2241:
2240:
2236:
2229:
2225:
2220:
2215:
2211:
2207:
2203:
2198:
2194:
2190:
2185:
2180:
2175:
2170:
2166:
2162:
2158:
2152:
2148:
2144:
2140:
2136:
2132:
2128:
2124:
2120:
2115:
2111:
2107:
2103:
2099:
2095:
2091:
2086:
2082:
2078:
2073:
2068:
2064:
2060:
2056:
2051:
2047:
2043:
2038:
2033:
2029:
2025:
2021:
2017:
2013:
2007:
2003:
1999:
1994:
1989:
1986:(7): 575–83.
1985:
1981:
1977:
1972:
1968:
1964:
1960:
1956:
1951:
1946:
1943:(9): 1063–8.
1942:
1938:
1934:
1929:
1925:
1921:
1916:
1911:
1907:
1903:
1899:
1895:
1891:
1885:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1851:
1847:
1842:
1838:
1834:
1829:
1824:
1820:
1816:
1813:(2): 273–90.
1812:
1808:
1804:
1798:
1794:
1790:
1785:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1752:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1708:
1704:
1700:
1695:
1690:
1686:
1682:
1678:
1672:
1671:
1666:
1658:
1654:
1650:
1646:
1642:
1638:
1631:
1628:
1623:
1619:
1615:
1611:
1606:
1601:
1597:
1593:
1589:
1585:
1581:
1574:
1571:
1566:
1562:
1557:
1552:
1548:
1544:
1540:
1536:
1532:
1525:
1522:
1517:
1513:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1468:
1465:
1460:
1447:
1438:
1433:
1429:
1423:
1420:
1415:
1411:
1406:
1401:
1398:(3): 1062–8.
1397:
1393:
1389:
1382:
1379:
1374:
1370:
1365:
1360:
1356:
1352:
1348:
1341:
1338:
1333:
1329:
1324:
1319:
1315:
1311:
1307:
1300:
1298:
1294:
1289:
1283:
1281:
1277:
1272:
1268:
1262:
1259:
1254:
1250:
1244:
1241:
1237:
1233:
1228:
1226:
1224:
1220:
1216:
1212:
1207:
1205:
1203:
1199:
1193:
1191:
1189:
1185:
1181:
1173:
1171:
1169:
1165:
1161:
1157:
1149:
1147:
1144:
1140:
1136:
1132:
1128:
1125:
1121:
1117:
1114:(IL-23). The
1113:
1109:
1105:
1104:
1099:
1095:
1082:
1077:
1073:
1069:
1066:
1062:
1055:
1053:
1050:
1046:
1042:
1038:
1035:
1031:
1027:
1020:
1018:
1012:
1008:
1005:
999:
997:
991:
987:
984:
980:
973:
971:
965:
961:
958:
952:
950:
944:
940:
937:
935:RefSeq (mRNA)
933:
926:
925:
920:
916:
913:
907:
906:
901:
897:
894:
892:
888:
881:
880:
875:
871:
868:
862:
861:
856:
852:
849:
847:
843:
836:
835:
830:
826:
823:
817:
816:
811:
807:
804:
802:
798:
795:
792:
790:
787:
783:
780:
776:
772:
765:
761:
756:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
616:
614:
611:
610:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
575:
573:
570:
569:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
452:adrenal gland
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
4530:
4518:M-CSFR/CSF1R
4505:heterodimer)
4491:heterodimer)
4420:Antagonists:
4419:
4391:
4370:
4349:
4309:
4288:
4261:Risankizumab
4242:
4232:
4224:
4210:
4200:
4183:NNC0114-0006
4178:NNC0114-0005
4174:
4159:
4137:
4117:
4096:
4071:
4025:
3990:
3964:
3947:Tralokinumab
3942:Lebrikizumab
3937:Anrukinzumab
3933:
3908:
3882:
3867:
3841:
3815:
3794:
3784:
3743:
3686:Clazakizumab
3677:
3662:
3641:
3625:Benralizumab
3621:
3612:Antagonists:
3611:
3601:
3584:Pascolizumab
3575:
3566:Antagonists:
3565:
3545:
3499:
3468:
3423:
3402:
3382:
3358:Antagonists:
3357:
3328:
3177:IL 17 family
2969:
2737:
2729:
2721:
2702:
2694:
2686:
2678:
2670:
2662:
2654:
2646:
2638:
2630:
2622:
2614:
2606:
2598:
2579:
2571:
2563:
2555:
2547:
2545:Fas receptor
2539:
2531:
2523:
2515:
2507:
2490:TNF receptor
2251:
2209:
2205:
2164:
2160:
2122:
2118:
2096:(8): 681–4.
2093:
2089:
2065:(3): 233–7.
2062:
2058:
2022:(8): 972–6.
2019:
2015:
1983:
1979:
1940:
1936:
1897:
1893:
1856:(5): 511–5.
1853:
1849:
1810:
1806:
1758:
1754:
1716:
1712:
1684:
1680:
1640:
1636:
1630:
1587:
1583:
1573:
1538:
1534:
1524:
1481:
1477:
1467:
1446:cite journal
1422:
1395:
1391:
1381:
1357:(7): 631–9.
1354:
1350:
1340:
1313:
1309:
1270:
1261:
1252:
1243:
1179:
1177:
1153:
1134:
1130:
1115:
1102:
1101:
1093:
1091:
1014:
993:
967:
946:
922:
903:
877:
858:
832:
813:
793:
788:
344:
337:
64:External IDs
4271:Ustekinumab
4251:Briakinumab
4243:Antibodies:
4214:Fezakinumab
4211:Antibodies:
4175:Antibodies:
4163:Denenicokin
4138:Antibodies:
4075:Iboctadekin
4054:Vunakizumab
4049:Secukinumab
4039:Perakizumab
4026:Antibodies:
3934:Antibodies:
3891:Ustekinumab
3886:Briakinumab
3883:Antibodies:
3795:Antibodies:
3721:Tocilizumab
3691:Elsilimomab
3678:Antibodies:
3630:Mepolizumab
3622:Antibodies:
3576:Antibodies:
3503:Daniplestim
3472:Basiliximab
3469:Antibodies:
3437:Celmoleukin
3432:Aldesleukin
3396:Lutikizumab
3391:Gevokizumab
3386:Canakinumab
3383:Antibodies:
2663:(TNFRSF13C)
2655:(TNFRSF13B)
2647:(TNFRSF12A)
2639:(TNFRSF11B)
2631:(TNFRSF11A)
2623:(TNFRSF10D)
2615:(TNFRSF10C)
2607:(TNFRSF10B)
2599:(TNFRSF10A)
2139:10261/75893
1590:(1): 43–7.
394:gallbladder
303:67,468,839
290:67,399,916
282:6|6 C1
202:67,259,979
189:67,138,907
42:Identifiers
4558:Categories
4326:B (IFN-λ3)
4322:A (IFN-λ2)
4256:Guselkumab
4246:Brazikumab
4141:Fletikumab
4044:Remtolumab
4034:Ixekizumab
4029:Brodalumab
3912:Binetrakin
3850:Oprelvekin
3819:Ilodecakin
3798:Enokizumab
3711:Siltuximab
3701:Olokizumab
3635:Reslizumab
3569:Pitrakinra
3549:Binetrakin
3518:Milodistim
3513:Leridistim
3482:Inolimomab
3457:Teceleukin
3376:Isunakinra
3313:modulators
2738:(TNFRSF27)
2730:(TNFRSF25)
2722:(TNFRSF21)
2703:(TNFRSF19)
2695:(TNFRSF18)
2687:(TNFRSF17)
2679:(TNFRSF16)
2671:(TNFRSF14)
2556:(TNFRSF6B)
2516:(TNFRSF1B)
2508:(TNFRSF1A)
1238:, May 2017
1217:, May 2017
1194:References
1124:N-terminal
348:(ortholog)
85:HomoloGene
4531:Unsorted:
4392:Agonists:
4371:Agonists:
4350:Agonists:
4310:Agonists:
4289:Agonists:
4233:Agonists:
4201:Agonists:
4160:Agonists:
4118:Agonists:
4090:Tadekinig
4072:Agonists:
3991:Agonists:
3965:Agonists:
3909:Agonists:
3868:Agonists:
3842:Agonists:
3816:Agonists:
3785:Agonists:
3744:Agonists:
3726:Levilimab
3716:Sirukumab
3706:Sarilumab
3663:Agonists:
3602:Agonists:
3579:Dupilumab
3546:Agonists:
3523:Muplestim
3500:Agonists:
3424:Agonists:
3351:Pifonakin
3346:Mobenakin
3329:Agonists:
3022:prolactin
2580:(TNFRSF9)
2572:(TNFRSF8)
2564:(TNFRSF7)
2548:(TNFRSF6)
2540:(TNFRSF5)
2532:(TNFRSF4)
2524:(TNFRSF3)
1017:NP_653131
996:NP_653302
970:NM_144548
949:NM_144701
779:Orthologs
468:esophagus
93:GeneCards
4485:IL-22Rα1
4451:instead.
3768:instead.
3696:mAb 1339
3681:ARGX-109
3645:TPI ASM8
3615:YM-90709
3366:Anakinra
3361:AF-12198
3251:TGF-beta
2752:JAK-STAT
2700:TAJ/TROY
2228:17854611
2193:17804789
2147:17678845
2110:17678723
2081:17661912
2046:17618837
2002:17534574
1967:21879558
1959:17508420
1924:17484863
1880:17309073
1837:17236132
1793:17068223
1741:35668044
1733:16372191
1703:12023369
1657:18675459
1622:21340871
1614:21151126
1565:21983784
1516:17068223
1414:25552541
1373:18754016
1332:12023369
1234:–
1213:–
1150:Function
1108:IL-12Rβ1
1065:Wikidata
758:Sources:
588:membrane
386:appendix
4503:IL-10Rβ
4499:IL-20Rα
4489:IL-20Rβ
4423:IL-36RA
3968:ALT-803
3247:Ser/Thr
3069:IL22RA2
3065:IL22RA1
3036:Type II
2965:IL12RB2
2961:IL12RB1
2944:IL12RB1
2843:β-chain
2812:IL13RA2
2808:IL13RA1
2770:γ-chain
2258:PDBe-KB
2248:UniProt
2184:1965486
2037:4287202
1915:2696256
1871:2169293
1828:1785338
1784:4410764
1763:Bibcode
1755:Science
1556:3378381
1507:4410764
1486:Bibcode
1478:Science
1236:Ensembl
1215:Ensembl
1160:IL12RB1
891:UniProt
846:Ensembl
785:Species
764:QuickGO
464:jejunum
323:pattern
81:2181693
49:Aliases
4459:Others
4432:Others
4384:IL1RL2
4363:IL1RL1
4100:IL18BP
3371:IL-1RA
3266:family
3261:TGFBR2
3256:TGFBR1
3210:IL17RE
3205:IL17RD
3200:IL17RC
3195:IL17RB
3190:IL17RA
3167:IL18R1
3120:IFNGR2
3116:IFNGR1
3107:IFNAR2
3103:IFNAR1
3082:IL20RB
3078:IL20RA
3057:IL10RB
3053:IL10RA
2987:other
2917:IL27RA
2908:IL11RA
2876:GM-CSF
2761:Type I
2644:TweakR
2476:CMKLR1
2454:CX3CR1
2253:Q5VWK5
2226:
2191:
2181:
2145:
2108:
2079:
2044:
2034:
2000:
1965:
1957:
1922:
1912:
1878:
1868:
1835:
1825:
1791:
1781:
1739:
1731:
1701:
1655:
1620:
1612:
1563:
1553:
1514:
1504:
1412:
1371:
1330:
1051:search
1049:PubMed
924:Q8K4B4
905:Q5VWK5
834:209590
815:149233
801:Entrez
494:BioGPS
456:thymus
448:embryo
444:embryo
432:zygote
378:rectum
181:1p31.3
73:607562
4342:IL-31
4302:IL-28
4281:IL-27
4225:IL-23
4193:IL-22
4152:IL-21
4110:IL-20
4064:IL-18
3983:IL-17
3957:IL-15
3901:IL-13
3860:IL-12
3834:IL-11
3808:IL-10
3235:CSF1R
3163:IL18R
3156:IL1R2
3151:IL1R1
3087:IL28R
3074:IL20R
3061:IL22R
3049:IL10R
2999:G-CSF
2981:Other
2970:IL23R
2957:IL12R
2934:CNTFR
2899:IL6RA
2886:gp130
2869:IL5RA
2860:IL3RA
2831:IL21R
2821:IL7RA
2804:IL13R
2795:IL15R
2791:IL2RB
2787:IL2RA
2735:EDA2R
2712:21-27
2660:BAFFR
2589:11-20
2577:CD137
2529:CD134
2513:TNFR2
2505:TNFR1
2471:CCBP2
2450:CX3C
2444:Other
2435:CXCR7
2430:CXCR6
2425:CXCR5
2420:CXCR4
2415:CXCR3
2408:CXCR2
2403:CXCR1
2380:CCR10
2340:CCRL2
2330:CCRL1
2308:GPCRs
1963:S2CID
1737:S2CID
1618:S2CID
1180:IL23R
1168:STAT3
1156:IL-23
1135:IL23R
1131:IL23R
1122:, an
1116:IL23R
1103:IL23R
1096:is a
794:Mouse
789:Human
760:Amigo
460:ileum
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
97:IL23R
89:16930
56:IL23R
33:IL23R
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3492:IL-3
3416:IL-2
3321:IL-1
3185:IL17
3099:-α/β
2929:LIFR
2924:OSMR
2865:IL5R
2856:IL3R
2826:IL9R
2817:IL7R
2800:IL4R
2783:IL2R
2692:GITR
2684:BCMA
2676:NGFR
2668:HVEM
2652:TACI
2628:RANK
2620:DcR2
2612:DcR1
2569:CD30
2561:CD27
2553:DcR3
2537:CD40
2521:LTBR
2498:1-10
2464:XCR1
2398:IL-8
2375:CCR9
2370:CCR8
2365:CCR7
2360:CCR6
2355:CCR5
2350:CCR4
2345:CCR3
2335:CCR2
2326:CCR1
2246:for
2224:PMID
2189:PMID
2143:PMID
2106:PMID
2077:PMID
2042:PMID
1998:PMID
1955:PMID
1920:PMID
1876:PMID
1833:PMID
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1699:PMID
1653:PMID
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2994:EPO
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2719:DR6
2604:DR5
2596:DR4
2460:XC
2390:CXC
2244:PDB
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2210:133
2179:PMC
2169:doi
2165:104
2135:hdl
2127:doi
2098:doi
2067:doi
2032:PMC
2024:doi
1988:doi
1945:doi
1910:PMC
1902:doi
1898:132
1866:PMC
1858:doi
1823:PMC
1815:doi
1779:PMC
1771:doi
1759:314
1721:doi
1689:doi
1685:168
1645:doi
1600:hdl
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1551:PMC
1543:doi
1502:PMC
1494:doi
1482:314
1432:doi
1400:doi
1396:194
1359:doi
1318:doi
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