1514:. In this condition, immune cells react to inflammatory molecules released within the skin around the joints and scalp. This response causes the epidermal cells to recycle more rapidly than usual, which leads to the formation of red, scaly lesions and chronic skin inflammation. Analysis of biopsies taken from lesions of psoriasis patients show an enrichment of cytotoxic T cells and neutrophils containing IL-17. This indicates an excessive infiltration of pro-inflammatory immune cells and IL-17 cytokines are associated with the development of psoriasis.
1699:
endothelial cells, peripheral T cells, B cell lineages, fibroblast, lung, myelomonocytic cells, and marrow stromal cells. Signal transduction for both IL-17A and IL-17F requires the presence of a heterodimeric complex consisting of both IL-17RA and IL-17RC and the absence of either receptor results in ineffective signal transduction. This pattern is reciprocated for other members of the IL-17 family such as IL-17E, which requires an IL-17RA-IL-17RB complex (also known as IL-17Rh1, IL-17BR or IL-25R) for effective function.
1609:. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors and activates the
1613:. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation and have important therapeutic implications in asthma.
881:
1596:
DCs are also recruited by CCL20 via chemotaxis where their activation restarts and amplifies the cycle of inflammation. IL-17 and additional cytokines released from the influx of neutrophils, T and dendritic cells mediate effects on localized leukocytes and keratinocytes that supports the progression of psoriasis by inciting chronic inflammation.
1595:
cells. Reduced regulation allows uninhibited proliferation of Th17 cells and production of IL-17 in psoriatic lesions, augmenting IL-17 signaling. Antimicrobial peptides and IL-8 attract neutrophils to the site of injury where these cells remove damaged and inflamed keratinocyte cells. New immature
1206:
Numerous immune regulatory functions have been reported for the IL-17 family of cytokines, presumably due to their induction of many immune signaling molecules. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with
1193:
shape of the entire protein molecule. To the reference, the members of the IL-17 family do not exhibit a significant sequence homology with other cytokines. Among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest sequence homology with IL-17A (55 and 40%, respectively). They
1698:
The IL-17 receptor family consists of five, broadly distributed receptors (IL-17RA, B, C, D and E) that present with individual ligand specificities. Within this family of receptors, IL-17RA is the best-described. IL-17RA binds both IL-17A and IL-17F and is expressed in multiple tissues: vascular
1707:
to produce a soluble receptor in addition to its cell membrane-bound form. In a similar manner, the gene for IL-17RD may undergo alternative splicing to yield a soluble receptor. This feature may allow these receptors to inhibit the stimulatory effects of their yet-undefined ligands. The
3312:
Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y, et al. (May 2008). "Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)".
1133:. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with
1702:
Another member of this receptor family, IL-17RB, binds both IL-17B and IL-17E. Furthermore, it is expressed in the kidney, pancreas, liver, brain, and intestine. IL-17RC is expressed by the prostate, cartilage, kidney, liver, heart, and muscle, and its gene may undergo
1289:
The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses. The increased expression of chemokines attracts other cells including neutrophils but not eosinophils. IL-17 function is also essential to a subset of
1711:
Signal transduction by these receptors is as diverse as their distribution. These receptors do not exhibit a significant similarity in extracellular or intracellular amino acid sequence when compared to other cytokine receptors. Transcription factors such as
1732:
have been implicated in IL-17 mediated signaling in a stimulation-dependent, tissue-specific manner. Other signaling mechanisms have also been proposed, but more work is needed to fully elucidate the true signaling pathways used by these diverse receptors.
1470:
site on the protein was first identified after purification of the protein revealed two bands, one at 15 KDa and another at 20 KDa. Comparison of different members of the IL-17 family revealed four conserved cysteines that form two
1660:
Based on emerging evidence from animal models, IL-17 has been suggested as a target for anti-inflammatory therapies to improve recovery post-stroke and to reduce the formation of skin cancer. IL-17 has also been implicated in
1604:
The IL-17F gene was discovered in 2001 and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo and has been shown to have a pro-inflammatory role in
1405:
regions of both IL-17A and IL-17F increasing their gene activity. In contrast, some scientists believe IL-17 induction is independent of IL-23. Several groups have identified ways to induce IL-17 production both
3196:
Cleve H, Kirk RL, Gajdusek DC, Guiart J (1967). "On the distribution of the Gc variant Gc
Aborigine in Melanesian populations; determination of Gc-types in sera from Tongariki Island, New Hebrides".
1422:, without the need for IL-23. Although IL-23 is not required for IL-17 expression in this situation, IL-23 may play a role in promoting survival and/or proliferation of the IL-17 producing
4769:
2607:
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. (May 2006). "Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells".
1525:. Similarly, mice genetically modifying to not express IL-23 or IL-17 receptors significantly reduced psoriatic lesion development upon stimulation with the lesion-causing tumor promoter
3231:
Seppälä M, Rönnberg L, Karonen SL, Kauppila A (August 1987). "Micronized oral progesterone increases the circulating level of endometrial secretory PP14/beta-lactoglobulin homologue".
1855:
Johansen C, Usher PA, Kjellerup RB, Lundsgaard D, Iversen L, Kragballe K (February 2009). "Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin".
1198:, the sequences of these cytokines are highly conserved. For instance, the sequence homology between the corresponding human and mouse proteins is usually between 62–88%.
1482:
The crystal structure of IL-17F, which is 50% homologous to IL-17A, revealed that IL-17F is structurally similar to the cystine knot family of proteins that includes the
4158:
116:
2272:
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage".
2402:"STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice"
4762:
915:
755:
608:
471:
326:
181:
1498:
replaces the cysteine at this position. This unique feature is conserved in the other IL-17 family members. IL-17F also dimerizes in a fashion similar to
1494:
stabilized by three disulfide interactions. However, in contrast to the other cystine knot proteins, IL-17F lacks the third disulfide bond. Instead, a
4755:
3287:
4234:
1536:
cells of the epidermal layer. Inflammation begins with keratinocyte cells entering the final stages of their cell cycle, which activates immature
5967:
5234:
4629:
6052:
6047:
6042:
5971:
5957:
5917:
1900:"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene"
1575:
IL-17 interaction with IL-17RA receptors, abundant on the keratinocyte cell surface, incite epidermal cells to increase expression of IL-6,
6037:
6032:
5986:
1526:
3654:
939:
779:
632:
495:
350:
205:
5891:
1517:
Studies conducted in mice demonstrate that removing either IL-23 or IL-17 decreases the progression of psoriasis. Mice injected with
4839:
4520:
1439:
1462:
with a molecular mass of 35 kDa. Each subunit of the homodimer is approximately 15-20 KDa. The structure of IL-17 consists of a
1649:, for the treatment of moderate to severe plaque psoriasis. In addition, Cosentyx has been approved in Japan for use in treating
927:
767:
620:
483:
338:
193:
920:
4050:
3077:
Dombrowski Y, Schauber J (May 2012). "Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis".
1982:"Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis"
760:
613:
476:
331:
1621:
Because of its involvement in immune regulatory functions, IL-17 inhibitors are being investigated as possible treatments for
186:
2770:
Hu Y, Shen F, Crellin NK, Ouyang W (January 2011). "The IL-17 pathway as a major therapeutic target in autoimmune diseases".
1764:"IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding"
1302:
17) cells. As a result of these roles, the IL-17 family has been linked to many immune-related/autoimmune diseases including
1141:. Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as
136:
5852:
5831:
3827:
3356:
Swardfager W, Winer DA, Herrmann N, Winer S, Lanctôt KL (March 2013). "Interleukin-17 in post-stroke neurodegeneration".
2505:"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells"
4663:
4213:
3988:
3288:"First in the world regulatory approval of Novartis' Cosentyx(TM) in Japan for both psoriasis and psoriatic arthritis"
1129:. After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of
2660:"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells"
4696:
4498:
4208:
1941:"Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis"
1634:
2361:"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17"
4617:
4302:
3401:"Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells"
1725:
4652:
4079:
4055:
1327:
1074:
1980:
Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, Nograles KE, Tian S, Cardinale I, et al. (March 2011).
1389:
signalling pathways are required for this IL-23-mediated IL-17 production. Consistent with this finding, Chen
124:
1358:. IL-17B is expressed in several peripheral tissues and immune tissues. IL-17C is also highly upregulated in
5810:
5770:
5749:
5693:
5661:
5620:
5578:
5532:
5451:
5425:
5369:
5328:
5302:
5276:
4930:
3647:
1708:
least-described of these receptors, IL-17RE, is known to be expressed in the pancreas, brain, and prostate.
1693:
1190:
1114:
5385:
3266:
5245:
5225:
5204:
5123:
5062:
5006:
4960:
4884:
4789:
3980:
3120:
Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N (December 2009). "Role of interleukin-17F in asthma".
1576:
1466:
of 23 amino acids (aa) followed by a 123-aa chain region characteristic of the IL-17 family. An N-linked
1346:
long and was cloned from CD4+ T cells. Each member of the IL-17 family has a distinct pattern of cellular
932:
772:
1820:
Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 receptors".
625:
488:
343:
198:
6057:
3291:
1521:
targeting IL-17 blocked, or neutralized, down-stream signaling of this cytokine and decreased epidermal
1518:
1134:
885:
825:
678:
541:
4895:
1194:
follow by IL-17B, which has 29% similarity to IL-17A, IL-17D (25%), IL-17C (23%), and IL-17E (17%). In
120:
6007:
3450:"Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression"
5790:
4778:
4506:
3028:
Krueger JG, Fretzin S, Suárez-Fariñas M, Haslett PA, Phipps KM, Cameron GS, et al. (July 2012).
2779:
2616:
2560:
2454:
1626:
1561:
1532:
IL-17 promotes psoriasis by contributing to the inflammatory response that damages and overturns the
1303:
997:
396:
251:
4920:
2658:
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. (September 2006).
2063:
Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, Russell CB (January 2013).
5781:
5339:
5134:
4910:
4804:
4348:
3030:"IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis"
1650:
1646:
1499:
1362:
conditions, although in resting conditions is low in abundance. IL-17D is highly expressed in the
1311:
1106:
5651:
5646:
5631:
5543:
5522:
4971:
4905:
4864:
4808:
4781:
4515:
4472:
4387:
4230:
4094:
3640:
3619:
3381:
3338:
3102:
2982:"Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model"
2803:
2689:
2640:
2586:
2297:
2254:
2202:
1880:
1704:
1662:
1622:
1402:
1323:
1275:
5512:
5380:
5287:
5266:
5017:
4986:
4981:
4925:
4844:
3547:"The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases"
2065:"The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings"
1587:. Increased concentration of IL-6 alters the epidermal environment by decreasing the ability of
1373:
Much progress has been made in the understanding of the regulation of IL-17. At first, Aggarwal
5558:
4991:
4819:
4814:
3157:"Growth and cytogenetic characteristics of bone marrow colonies from patients with 5q-syndrome"
5164:
5149:
5113:
5083:
4829:
4379:
3998:
3864:
3611:
3576:
3527:
3481:
3430:
3373:
3330:
3248:
3213:
3178:
3137:
3094:
3059:
3003:
2959:
2905:
2855:
2795:
2747:
2681:
2632:
2578:
2547:
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, et al. (May 2006).
2526:
2482:
2423:
2382:
2341:
2318:
Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ (December 1995).
2289:
2246:
2194:
2148:
2094:
2038:
2003:
1962:
1921:
1872:
1837:
1793:
1752:
1479:. Furthermore, IL-17 bears no resemblance to any other known proteins or structural domains.
1255:
951:
111:
1350:. The expression of IL-17A and IL-17F appear to be restricted to a small group of activated
6002:
4691:
4612:
4480:
4169:
4003:
3603:
3566:
3558:
3517:
3471:
3461:
3420:
3412:
3399:
Ortiz ML, Kumar V, Martner A, Mony S, Donthireddy L, Condamine T, et al. (March 2015).
3365:
3322:
3240:
3205:
3168:
3129:
3086:
3049:
3041:
2993:
2949:
2941:
2930:"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis"
2897:
2845:
2837:
2787:
2737:
2729:
2671:
2624:
2568:
2516:
2472:
2462:
2413:
2372:
2331:
2281:
2236:
2184:
2138:
2084:
2076:
2030:
1993:
1952:
1911:
1864:
1829:
1783:
1775:
1681:
1610:
1592:
1569:
1435:
1397:, plays an important role in IL-17 production. In the absence of SOCS3, IL-23-induced STAT3
1295:
1279:
1259:
992:
829:
820:
673:
536:
400:
391:
246:
5478:
5474:
5470:
2980:
Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, et al. (April 2011).
2319:
1899:
1510:
Recent work suggests the IL-23/IL-17 pathway plays a major role in the autoimmune disorder
1166:
1162:
1158:
103:
5794:
4218:
3904:
3594:
Ley K, Smith E, Stark MA (2006). "IL-17A-producing neutrophil-regulatory Tn lymphocytes".
3244:
2884:
Mudigonda P, Mudigonda T, Feneran AN, Alamdari HS, Sandoval L, Feldman SR (October 2012).
2733:
2401:
2021:
Miossec P, Korn T, Kuchroo VK (August 2009). "Interleukin-17 and type 17 helper T cells".
1398:
1367:
1347:
1244:
1021:
849:
702:
682:
565:
545:
420:
275:
2928:
Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M, Yalavarthi S, et al. (July 2011).
1940:
1001:
255:
2886:"Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis"
2783:
2620:
2564:
2458:
5992:
5982:
5977:
5963:
5949:
5939:
5934:
5881:
5863:
5842:
5821:
5800:
5786:
5760:
5704:
5672:
5636:
5599:
5594:
5589:
5553:
5548:
5441:
5395:
5344:
5313:
5292:
5027:
4996:
4732:
4727:
4582:
4560:
4555:
4358:
4353:
4343:
4338:
4333:
4328:
4323:
4319:
4288:
4283:
4278:
4257:
4252:
4247:
4242:
4197:
4192:
4187:
4182:
4130:
4115:
4106:
3663:
3571:
3546:
3476:
3449:
3425:
3400:
3054:
3029:
2954:
2929:
2850:
2825:
2742:
2717:
2477:
2442:
2441:
Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu BM, Tato C, et al. (May 2006).
2089:
2064:
1762:
Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, et al. (October 2001).
1537:
1472:
1463:
1378:
1363:
1271:
1240:
1178:
1066:
1058:
748:
3326:
1833:
1788:
1763:
6026:
5734:
5390:
5256:
5215:
5139:
5073:
5022:
4976:
4915:
4800:
4722:
4717:
4712:
4658:
4607:
4273:
4177:
4153:
4148:
4125:
4120:
4111:
4102:
3884:
3562:
3090:
2791:
1884:
1868:
1580:
1549:
1545:
1467:
1455:
1419:
1283:
1263:
1236:
1220:
1208:
1138:
1095:(see below). IL17A protein exhibits a high homology with a viral IL-17-like protein (
3623:
3385:
3369:
3342:
3106:
2807:
2443:"Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells"
2301:
2285:
2258:
2206:
65:
5908:
5729:
5415:
5410:
5405:
5154:
5093:
5052:
4203:
4035:
2693:
2644:
2590:
1717:
1533:
1487:
1483:
1459:
1382:
1359:
1355:
1102:
1092:
1051:
99:
4747:
1207:
allergic responses. IL-17 induces the production of many other cytokines (such as
2521:
2504:
2336:
2143:
2126:
1916:
968:
796:
649:
512:
367:
222:
77:
5739:
5719:
5682:
5517:
5507:
5359:
5354:
5189:
5159:
5098:
4940:
4900:
4859:
4854:
4624:
4570:
4311:
4070:
3993:
3173:
3156:
3133:
2418:
1654:
1642:
1638:
1522:
1491:
1476:
1267:
1251:
1031:
859:
712:
575:
430:
285:
3522:
3505:
3045:
2841:
2676:
2659:
2447:
Proceedings of the
National Academy of Sciences of the United States of America
1957:
1779:
5724:
5714:
5609:
5502:
5497:
5318:
5179:
5169:
5103:
5037:
4950:
4945:
4874:
4677:
4370:
4060:
4020:
3607:
2503:
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (February 2006).
1721:
1657:
can also be used to effectively treat psoriasis by indirectly reducing IL-17.
1553:
1232:
1130:
1062:
975:
803:
656:
519:
374:
229:
2998:
2981:
2945:
5194:
5184:
5174:
5047:
3682:
3632:
3466:
2467:
1669:
1630:
1565:
1541:
1511:
1451:
1343:
1319:
1315:
1142:
1084:
17:
3615:
3580:
3531:
3485:
3434:
3377:
3334:
3141:
3098:
3063:
3007:
2963:
2909:
2885:
2859:
2799:
2751:
2685:
2636:
2582:
2549:"Transforming growth factor-beta induces development of the T(H)17 lineage"
2530:
2486:
2427:
2400:
Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, et al. (May 2006).
2386:
2377:
2360:
2293:
2241:
2224:
2198:
2152:
2098:
2042:
2007:
1966:
1876:
1841:
1797:
1540:(DC). Cytokines released from DCs stimulate dying keratinocytes to secrete
3252:
3217:
3182:
2345:
2250:
2034:
1925:
1113:
The biologically active IL-17 interacts with type I cell surface receptor
4834:
4672:
3667:
3416:
2359:
Aggarwal S, Ghilardi N, Xie MH, de
Sauvage FJ, Gurney AL (January 2003).
2080:
1998:
1981:
1729:
1415:
1386:
1228:
1224:
1186:
1097:
1054:
980:
808:
661:
524:
379:
234:
72:
2628:
2573:
2548:
5953:
5436:
2901:
2189:
2172:
1557:
1351:
1182:
880:
32:
This article is about the protein family. For its founding member, see
3209:
1756:
1189:
residues. These conserved cysteine residues are critical to the right
1117:. In turn, there are at least three variants of IL-17R referred to as
956:
5568:
4550:
4447:
4442:
4437:
4432:
4427:
4422:
4140:
3945:
3929:
3924:
3919:
3914:
3909:
3899:
3894:
1898:
Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993).
1606:
1495:
1431:
1423:
1307:
1216:
1195:
1126:
1122:
1118:
1081:
1078:
963:
791:
644:
507:
362:
217:
131:
5875:
5871:
5867:
5486:
5482:
5466:
4586:
4545:
4540:
4535:
4530:
4525:
4462:
4452:
4417:
4412:
4407:
4402:
4397:
4392:
4045:
4040:
4030:
4015:
4010:
3889:
3879:
3874:
3869:
3859:
3854:
3848:
3832:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3504:
Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK (December 2004).
1673:
1588:
1584:
1394:
1370:
and IL-17E is found at low levels in various peripheral tissues.
1212:
1174:
1170:
1154:
166:
151:
33:
1475:. IL-17 is unique in that it bears no resemblance to other known
1185:
structure. Their protein sequences contain four highly conserved
4510:
4457:
4025:
3966:
3961:
3741:
3736:
3731:
3726:
3720:
3714:
3708:
3702:
3697:
1713:
1339:
944:
784:
637:
500:
355:
210:
93:
60:
4751:
3636:
5943:
3155:
Carbonell F, Heimpel H, Kubanek B, Fliedner TM (August 1985).
1291:
2225:"T. Duckett Jones and his association with Paul Dudley White"
1939:
Starnes T, Broxmeyer HE, Robertson MJ, Hromas R (July 2002).
3545:
Pappu R, Ramirez-Carrozzi V, Sambandam A (September 2011).
1282:
in mice) to induce expression of antimicrobial peptide by
1568:
to the epidermis. These cells release IL-23 which induce
2173:"IL-17: prototype member of an emerging cytokine family"
1672:
has been found to 'severely impair' production of the
1442:, directs differentiation of IL-17-producing T cells.
1110:. In rodents, IL-17A is often referred to as CTLA8.
1069:. Originally, Th17 was identified in 1993 by Rouvier
2320:"Human IL-17: a novel cytokine derived from T cells"
5927:
5907:
5900:
5851:
5830:
5809:
5769:
5748:
5692:
5660:
5619:
5577:
5531:
5450:
5424:
5368:
5327:
5301:
5275:
5244:
5224:
5203:
5122:
5061:
5005:
4959:
4883:
4788:
4642:
4600:
4569:
4497:
4471:
4378:
4369:
4310:
4301:
4266:
4229:
4167:
4139:
4093:
4078:
4069:
3979:
3954:
3938:
3841:
3690:
3681:
3674:
1401:is enhanced, and phosphorylated STAT3 binds to the
1027:
1017:
1012:
991:
986:
974:
962:
950:
938:
926:
914:
906:
898:
893:
873:
855:
845:
840:
819:
814:
802:
790:
778:
766:
754:
744:
736:
731:
726:
708:
698:
693:
672:
667:
655:
643:
631:
619:
607:
599:
594:
589:
571:
561:
556:
535:
530:
518:
506:
494:
482:
470:
462:
454:
449:
444:
426:
416:
411:
390:
385:
373:
361:
349:
337:
325:
317:
309:
304:
299:
281:
271:
266:
245:
240:
228:
216:
204:
192:
180:
172:
162:
157:
150:
130:
110:
92:
87:
71:
59:
51:
46:
41:
1181:. All members of the IL-17 family have a similar
2879:
2877:
2875:
2873:
2871:
2869:
1377:showed that production of IL-17 was dependent on
3499:
3497:
3495:
2975:
2973:
2127:"Interleukin-17 family members and inflammation"
3269:. U.S. Food and Drug Administration. 2015-01-21
3023:
3021:
3019:
3017:
2819:
2817:
2716:Lowes MA, Suárez-Fariñas M, Krueger JG (2014).
2602:
2600:
2498:
2496:
1637:. In January 2015, the FDA approved the use of
1450:IL-17(A) is a 155-amino acid protein that is a
3510:The Journal of Allergy and Clinical Immunology
3034:The Journal of Allergy and Clinical Immunology
2824:Baliwag J, Barnes DH, Johnston A (June 2015).
1815:
1813:
1811:
1809:
1807:
1747:
1745:
4763:
3648:
2711:
2709:
2707:
2705:
2703:
2542:
2540:
2218:
2216:
2058:
2056:
2054:
2052:
1318:rejection, anti-tumour immunity and recently
8:
1490:fold is characterized by two sets of paired
3448:Chang SH, Chung Y, Dong C (December 2010).
2923:
2921:
2919:
2120:
2118:
2116:
2114:
2112:
2110:
2108:
5904:
4770:
4756:
4748:
4375:
4307:
4090:
4075:
3687:
3678:
3655:
3641:
3633:
3267:"FDA approves new psoriasis drug Cosentyx"
2772:Annals of the New York Academy of Sciences
2765:
2763:
2761:
2313:
2311:
2166:
2164:
2162:
1101:) encoded in the genome of T-lymphotropic
1009:
879:
837:
690:
553:
408:
263:
84:
3570:
3521:
3475:
3465:
3424:
3290:. Novartis AG. 2014-12-26. Archived from
3172:
3122:Inflammation & Allergy - Drug Targets
3053:
2997:
2953:
2849:
2741:
2675:
2572:
2520:
2476:
2466:
2417:
2376:
2335:
2240:
2223:Paul O, Bland EF, Massell BF (May 1990).
2188:
2142:
2088:
1997:
1956:
1915:
1787:
5935:Interleukin 14 (taxilin alpha, HMW-BCGF)
2069:The Journal of Investigative Dermatology
1986:The Journal of Investigative Dermatology
1381:. Later, a Korean group discovered that
1157:(sometimes confusingly called "IL-17"),
1741:
5233:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
3358:Neuroscience and Biobehavioral Reviews
2171:Aggarwal S, Gurney AL (January 2002).
1065:in response to their stimulation with
870:
723:
586:
441:
296:
147:
38:
3245:10.1093/oxfordjournals.humrep.a136569
2734:10.1146/annurev-immunol-032713-120225
1153:The IL-17 family in humans comprises
7:
3405:The Journal of Experimental Medicine
1822:Cytokine & Growth Factor Reviews
1527:12-O-tetradecanoylphorbol-13-acetate
3454:The Journal of Biological Chemistry
2365:The Journal of Biological Chemistry
2125:Kolls JK, Lindén A (October 2004).
2023:The New England Journal of Medicine
1677:
3198:Acta Genetica et Statistica Medica
1857:The British Journal of Dermatology
1057:. They are produced by a group of
1050:) is a family of pro-inflammatory
25:
3563:10.1111/j.1365-2567.2011.03465.x
3091:10.1111/j.1600-0625.2012.01459.x
2792:10.1111/j.1749-6632.2010.05825.x
1869:10.1111/j.1365-2133.2008.08902.x
5761:Interleukin 27 (interleukin 30)
3370:10.1016/j.neubiorev.2013.01.021
2286:10.1016/j.pneurobio.2019.03.003
1502:(NGF) and other neurotrophins.
1414:by distinct cytokines, called
1393:showed that another molecule,
1:
3327:10.1016/S0140-6736(08)60725-4
1834:10.1016/S1359-6101(03)00002-9
88:Available protein structures:
6053:Genes on human chromosome 14
6048:Genes on human chromosome 13
6043:Genes on human chromosome 16
2522:10.1016/j.immuni.2006.01.001
2337:10.4049/jimmunol.155.12.5483
2177:Journal of Leukocyte Biology
2144:10.1016/j.immuni.2004.08.018
1917:10.4049/jimmunol.150.12.5445
6038:Genes on human chromosome 5
6033:Genes on human chromosome 6
5111:Antisense oligonucleotides:
3174:10.1182/blood.V66.2.463.463
3134:10.2174/1871528110908050383
2722:Annual Review of Immunology
2419:10.4049/jimmunol.176.9.5652
1591:to control the behavior of
6074:
3523:10.1016/j.jaci.2004.10.019
3046:10.1016/j.jaci.2012.04.024
2890:Dermatology Online Journal
2842:10.1016/j.cyto.2014.12.014
2677:10.1016/j.cell.2006.07.035
1958:10.4049/jimmunol.169.2.642
1691:
1653:. The anti-IL-23 antibody
1635:inflammatory bowel disease
1611:MAP kinase-related pathway
1177:. IL-17E is also known as
886:Crystallographic structure
31:
4618:Colony-stimulating factor
3516:(6): 1265–73, quiz 1274.
2718:"Immunology of psoriasis"
1354:, and upregulated during
1342:for human IL-17A is 1874
1250:) from many cell types (
1239:, GRO-α, and MCP-1), and
1087:. The protein encoded by
1008:
878:
836:
689:
552:
407:
262:
83:
4653:proinflammatory cytokine
3079:Experimental Dermatology
2999:10.4049/jimmunol.1000148
2946:10.4049/jimmunol.1100123
2826:"Cytokines in psoriasis"
2274:Progress in Neurobiology
1780:10.1093/emboj/20.19.5332
1572:cells to produce IL-17.
1328:intracerebral hemorrhage
1278:cells in humans, but by
1091:is a founding member of
888:of dimeric human IL-17f.
5801:Interleukin-29 (IFN-λ1)
4946:Daclizumab (dacliximab)
4931:Tucotuzumab celmoleukin
3506:"IL-17 cytokine family"
3467:10.1074/jbc.C110.185777
2468:10.1073/pnas.0600666103
1694:Interleukin-17 receptor
1645:), an IL-17 inhibiting
5782:Interferon λ4 (IFN-λ4)
4875:Rilonacept (IL-1 Trap)
3784:/PARC/DCCK1/AMAC1/MIP4
2378:10.1074/jbc.M207577200
2242:10.1002/clc.4960130511
1577:antimicrobial peptides
5705:Interleukin 23 (SGRF)
5386:Cintredekin besudotox
5314:Interleukin 11 (AGIF)
5293:Interleukin 10 (CSIF)
2986:Journal of Immunology
2934:Journal of Immunology
2406:Journal of Immunology
2324:Journal of Immunology
2035:10.1056/NEJMra0707449
1945:Journal of Immunology
1904:Journal of Immunology
1519:monoclonal antibodies
1135:tumor necrosis factor
1044:Interleukin 17 family
42:Interleukin 17 family
4779:Interleukin receptor
3596:Immunologic Research
3417:10.1084/jem.20140835
2081:10.1038/jid.2012.194
1999:10.1038/jid.2010.340
1627:rheumatoid arthritis
1562:natural killer cells
1304:rheumatoid arthritis
1274:(produced mainly by
4911:Denileukin diftitox
4349:Interferon type III
3608:10.1385/IR:34:3:229
2784:2011NYASA1217...60H
2629:10.1038/nature04753
2621:2006Natur.441..235B
2574:10.1038/nature04754
2565:2006Natur.441..231M
2459:2006PNAS..103.8137C
2229:Clinical Cardiology
1668:The active form of
1651:psoriatic arthritis
1647:monoclonal antibody
1623:autoimmune diseases
1500:nerve growth factor
1426:. Recently, Ivanov
1270:). IL-17 acts with
1107:Herpesvirus saimiri
1073:who isolated IL17A
5483:E (interleukin 25)
3233:Human Reproduction
2902:10.5070/D33N39N8XM
2190:10.1189/jlb.71.1.1
1705:alternate splicing
1663:multiple sclerosis
1617:Therapeutic target
1589:T regulatory cells
1324:multiple sclerosis
6020:
6019:
6016:
6015:
5985:(signals through
5966:(signals through
5952:(signals through
5942:(signals through
5566:Binding proteins:
4896:Adargileukin alfa
4745:
4744:
4638:
4637:
4596:
4595:
4493:
4492:
4489:
4488:
4297:
4296:
3975:
3974:
3321:(9625): 1665–74.
3210:10.1159/000152104
1506:Role in psoriasis
1294:+ T-Cells called
1256:endothelial cells
1041:
1040:
1037:
1036:
869:
868:
865:
864:
722:
721:
718:
717:
585:
584:
581:
580:
440:
439:
436:
435:
295:
294:
291:
290:
146:
145:
142:
141:
137:structure summary
29:Group of proteins
16:(Redirected from
6065:
6008:Efineptakin alfa
6003:Efavaleukin alfa
5905:
4872:Decoy receptors:
4772:
4765:
4758:
4749:
4376:
4308:
4091:
4076:
3688:
3679:
3657:
3650:
3643:
3634:
3628:
3627:
3591:
3585:
3584:
3574:
3542:
3536:
3535:
3525:
3501:
3490:
3489:
3479:
3469:
3445:
3439:
3438:
3428:
3396:
3390:
3389:
3353:
3347:
3346:
3309:
3303:
3302:
3300:
3299:
3284:
3278:
3277:
3275:
3274:
3263:
3257:
3256:
3228:
3222:
3221:
3193:
3187:
3186:
3176:
3152:
3146:
3145:
3117:
3111:
3110:
3074:
3068:
3067:
3057:
3040:(1): 145–54.e9.
3025:
3012:
3011:
3001:
2977:
2968:
2967:
2957:
2925:
2914:
2913:
2881:
2864:
2863:
2853:
2821:
2812:
2811:
2767:
2756:
2755:
2745:
2713:
2698:
2697:
2679:
2655:
2649:
2648:
2604:
2595:
2594:
2576:
2544:
2535:
2534:
2524:
2500:
2491:
2490:
2480:
2470:
2438:
2432:
2431:
2421:
2397:
2391:
2390:
2380:
2356:
2350:
2349:
2339:
2315:
2306:
2305:
2269:
2263:
2262:
2244:
2220:
2211:
2210:
2192:
2168:
2157:
2156:
2146:
2122:
2103:
2102:
2092:
2060:
2047:
2046:
2018:
2012:
2011:
2001:
1977:
1971:
1970:
1960:
1936:
1930:
1929:
1919:
1895:
1889:
1888:
1852:
1846:
1845:
1817:
1802:
1801:
1791:
1768:The EMBO Journal
1759:
1749:
1436:nuclear receptor
1280:T helper 17 cell
1260:epithelial cells
1100:
1063:T helper 17 cell
1010:
883:
871:
838:
724:
691:
587:
554:
442:
409:
297:
264:
148:
85:
39:
21:
6073:
6072:
6068:
6067:
6066:
6064:
6063:
6062:
6023:
6022:
6021:
6012:
5923:
5896:
5847:
5826:
5805:
5765:
5744:
5688:
5685:(against IL-22)
5656:
5615:
5612:(against IL-20)
5573:
5527:
5446:
5420:
5364:
5323:
5297:
5271:
5240:
5220:
5199:
5118:
5057:
5001:
4955:
4879:
4784:
4776:
4746:
4741:
4707:
4686:
4644:
4634:
4592:
4565:
4485:
4467:
4365:
4293:
4262:
4225:
4163:
4135:
4086:
4084:
4082:
4065:
3971:
3950:
3934:
3837:
3670:
3661:
3631:
3593:
3592:
3588:
3544:
3543:
3539:
3503:
3502:
3493:
3460:(50): 38751–5.
3447:
3446:
3442:
3398:
3397:
3393:
3355:
3354:
3350:
3311:
3310:
3306:
3297:
3295:
3286:
3285:
3281:
3272:
3270:
3265:
3264:
3260:
3230:
3229:
3225:
3195:
3194:
3190:
3154:
3153:
3149:
3119:
3118:
3114:
3076:
3075:
3071:
3027:
3026:
3015:
2979:
2978:
2971:
2927:
2926:
2917:
2883:
2882:
2867:
2823:
2822:
2815:
2769:
2768:
2759:
2715:
2714:
2701:
2657:
2656:
2652:
2615:(7090): 235–8.
2606:
2605:
2598:
2559:(7090): 231–4.
2546:
2545:
2538:
2502:
2501:
2494:
2453:(21): 8137–42.
2440:
2439:
2435:
2399:
2398:
2394:
2358:
2357:
2353:
2317:
2316:
2309:
2271:
2270:
2266:
2222:
2221:
2214:
2170:
2169:
2160:
2124:
2123:
2106:
2062:
2061:
2050:
2020:
2019:
2015:
1979:
1978:
1974:
1938:
1937:
1933:
1910:(12): 5445–56.
1897:
1896:
1892:
1854:
1853:
1849:
1819:
1818:
1805:
1774:(19): 5332–41.
1761:
1751:
1750:
1743:
1739:
1696:
1690:
1619:
1602:
1552:leading to the
1538:dendritic cells
1508:
1473:disulfide bonds
1448:
1430:found that the
1399:phosphorylation
1368:skeletal muscle
1336:
1334:Gene expression
1301:
1249:
1204:
1151:
1096:
889:
874:Interleukin 17F
727:Interleukin 17E
590:Interleukin 17D
445:Interleukin 17C
300:Interleukin 17B
152:Interleukin 17A
37:
30:
23:
22:
15:
12:
11:
5:
6071:
6069:
6061:
6060:
6055:
6050:
6045:
6040:
6035:
6025:
6024:
6018:
6017:
6014:
6013:
6011:
6010:
6005:
5996:
5995:
5993:Interleukin 35
5990:
5983:Interleukin 34
5980:
5978:Interleukin 32
5975:
5964:Interleukin 26
5961:
5950:Interleukin 24
5947:
5940:Interleukin 16
5937:
5931:
5929:
5925:
5924:
5922:
5921:
5913:
5911:
5902:
5898:
5897:
5895:
5894:
5885:
5884:
5882:Interleukin 38
5879:
5864:Interleukin 36
5857:
5855:
5849:
5848:
5846:
5845:
5843:Interleukin 33
5836:
5834:
5828:
5827:
5825:
5824:
5822:Interleukin 31
5815:
5813:
5807:
5806:
5804:
5803:
5798:
5787:Interleukin 28
5784:
5775:
5773:
5767:
5766:
5764:
5763:
5754:
5752:
5746:
5745:
5743:
5742:
5737:
5732:
5727:
5722:
5717:
5708:
5707:
5698:
5696:
5690:
5689:
5687:
5686:
5676:
5675:
5673:Interleukin 22
5666:
5664:
5658:
5657:
5655:
5654:
5649:
5640:
5639:
5637:Interleukin 21
5634:
5625:
5623:
5617:
5616:
5614:
5613:
5603:
5602:
5600:Interleukin 24
5597:
5595:Interleukin 20
5592:
5590:Interleukin 19
5583:
5581:
5575:
5574:
5572:
5571:
5562:
5561:
5556:
5554:Interleukin 37
5551:
5549:Interleukin 18
5546:
5537:
5535:
5529:
5528:
5526:
5525:
5520:
5515:
5510:
5505:
5500:
5491:
5490:
5463:Interleukin 17
5456:
5454:
5448:
5447:
5445:
5444:
5442:Interleukin 15
5439:
5430:
5428:
5422:
5421:
5419:
5418:
5413:
5408:
5399:
5398:
5396:Interleukin 13
5393:
5388:
5383:
5374:
5372:
5366:
5365:
5363:
5362:
5357:
5348:
5347:
5345:Interleukin 12
5342:
5333:
5331:
5325:
5324:
5322:
5321:
5316:
5307:
5305:
5299:
5298:
5296:
5295:
5290:
5281:
5279:
5273:
5272:
5270:
5269:
5260:
5259:
5250:
5248:
5242:
5241:
5239:
5238:
5230:
5228:
5222:
5221:
5219:
5218:
5209:
5207:
5201:
5200:
5198:
5197:
5192:
5187:
5182:
5177:
5172:
5167:
5162:
5157:
5152:
5143:
5142:
5137:
5128:
5126:
5120:
5119:
5117:
5116:
5107:
5106:
5101:
5096:
5087:
5086:
5077:
5076:
5067:
5065:
5059:
5058:
5056:
5055:
5050:
5041:
5040:
5031:
5030:
5028:Interleukin 13
5025:
5020:
5011:
5009:
5003:
5002:
5000:
4999:
4997:Promegapoietin
4994:
4989:
4984:
4979:
4974:
4965:
4963:
4957:
4956:
4954:
4953:
4948:
4943:
4934:
4933:
4928:
4923:
4921:Pegaldesleukin
4918:
4913:
4908:
4903:
4898:
4889:
4887:
4881:
4880:
4878:
4877:
4868:
4867:
4862:
4857:
4848:
4847:
4842:
4837:
4832:
4823:
4822:
4817:
4812:
4794:
4792:
4786:
4785:
4777:
4775:
4774:
4767:
4760:
4752:
4743:
4742:
4740:
4739:
4738:
4737:
4736:
4735:
4730:
4725:
4720:
4715:
4705:
4701:
4700:
4699:
4694:
4684:
4675:
4669:
4668:
4667:
4666:
4661:
4648:
4646:
4640:
4639:
4636:
4635:
4633:
4632:
4627:
4622:
4621:
4620:
4615:
4604:
4602:
4598:
4597:
4594:
4593:
4591:
4590:
4575:
4573:
4567:
4566:
4564:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4503:
4501:
4499:Ig superfamily
4495:
4494:
4491:
4490:
4487:
4486:
4484:
4483:
4477:
4475:
4469:
4468:
4466:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4384:
4382:
4373:
4367:
4366:
4364:
4363:
4362:
4361:
4356:
4346:
4341:
4336:
4331:
4326:
4316:
4314:
4305:
4299:
4298:
4295:
4294:
4292:
4291:
4286:
4281:
4276:
4270:
4268:
4264:
4263:
4261:
4260:
4255:
4250:
4245:
4239:
4237:
4227:
4226:
4224:
4223:
4222:
4221:
4216:
4211:
4206:
4195:
4190:
4185:
4180:
4174:
4172:
4165:
4164:
4162:
4161:
4156:
4151:
4145:
4143:
4137:
4136:
4134:
4133:
4128:
4123:
4118:
4109:
4099:
4097:
4088:
4073:
4067:
4066:
4064:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4008:
4007:
4006:
4001:
3991:
3985:
3983:
3977:
3976:
3973:
3972:
3970:
3969:
3964:
3958:
3956:
3952:
3951:
3949:
3948:
3942:
3940:
3936:
3935:
3933:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3845:
3843:
3839:
3838:
3836:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3795:
3790:
3785:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3718:
3712:
3706:
3700:
3694:
3692:
3685:
3676:
3672:
3671:
3664:Cell signaling
3662:
3660:
3659:
3652:
3645:
3637:
3630:
3629:
3586:
3537:
3491:
3440:
3391:
3348:
3304:
3279:
3258:
3223:
3188:
3147:
3112:
3069:
3013:
2969:
2940:(1): 490–500.
2915:
2865:
2813:
2757:
2699:
2670:(6): 1121–33.
2650:
2596:
2536:
2492:
2433:
2412:(9): 5652–61.
2392:
2351:
2330:(12): 5483–6.
2307:
2264:
2212:
2158:
2104:
2048:
2013:
1972:
1931:
1890:
1847:
1803:
1740:
1738:
1735:
1689:
1686:
1618:
1615:
1601:
1600:Role in asthma
1598:
1507:
1504:
1464:signal peptide
1447:
1444:
1364:nervous system
1335:
1332:
1299:
1247:
1241:prostaglandins
1203:
1200:
1150:
1149:Family members
1147:
1039:
1038:
1035:
1034:
1029:
1025:
1024:
1019:
1015:
1014:
1006:
1005:
995:
989:
988:
984:
983:
978:
972:
971:
966:
960:
959:
954:
948:
947:
942:
936:
935:
930:
924:
923:
918:
912:
911:
908:
904:
903:
900:
896:
895:
891:
890:
884:
876:
875:
867:
866:
863:
862:
857:
853:
852:
847:
843:
842:
834:
833:
823:
817:
816:
812:
811:
806:
800:
799:
794:
788:
787:
782:
776:
775:
770:
764:
763:
758:
752:
751:
746:
742:
741:
738:
734:
733:
729:
728:
720:
719:
716:
715:
710:
706:
705:
700:
696:
695:
687:
686:
676:
670:
669:
665:
664:
659:
653:
652:
647:
641:
640:
635:
629:
628:
623:
617:
616:
611:
605:
604:
601:
597:
596:
592:
591:
583:
582:
579:
578:
573:
569:
568:
563:
559:
558:
550:
549:
539:
533:
532:
528:
527:
522:
516:
515:
510:
504:
503:
498:
492:
491:
486:
480:
479:
474:
468:
467:
464:
460:
459:
456:
452:
451:
447:
446:
438:
437:
434:
433:
428:
424:
423:
418:
414:
413:
405:
404:
394:
388:
387:
383:
382:
377:
371:
370:
365:
359:
358:
353:
347:
346:
341:
335:
334:
329:
323:
322:
319:
315:
314:
311:
307:
306:
302:
301:
293:
292:
289:
288:
283:
279:
278:
273:
269:
268:
260:
259:
249:
243:
242:
238:
237:
232:
226:
225:
220:
214:
213:
208:
202:
201:
196:
190:
189:
184:
178:
177:
174:
170:
169:
164:
160:
159:
155:
154:
144:
143:
140:
139:
134:
128:
127:
114:
108:
107:
97:
90:
89:
81:
80:
75:
69:
68:
63:
57:
56:
53:
49:
48:
44:
43:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6070:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6030:
6028:
6009:
6006:
6004:
6001:
5998:
5997:
5994:
5991:
5988:
5984:
5981:
5979:
5976:
5973:
5969:
5965:
5962:
5959:
5955:
5951:
5948:
5945:
5941:
5938:
5936:
5933:
5932:
5930:
5926:
5919:
5915:
5914:
5912:
5910:
5906:
5903:
5899:
5893:
5890:
5887:
5886:
5883:
5880:
5877:
5873:
5869:
5865:
5862:
5859:
5858:
5856:
5854:
5850:
5844:
5841:
5838:
5837:
5835:
5833:
5829:
5823:
5820:
5817:
5816:
5814:
5812:
5808:
5802:
5799:
5796:
5792:
5788:
5785:
5783:
5780:
5777:
5776:
5774:
5772:
5768:
5762:
5759:
5756:
5755:
5753:
5751:
5747:
5741:
5738:
5736:
5735:Tildrakizumab
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5710:
5709:
5706:
5703:
5700:
5699:
5697:
5695:
5691:
5684:
5681:
5678:
5677:
5674:
5671:
5668:
5667:
5665:
5663:
5659:
5653:
5650:
5648:
5645:
5642:
5641:
5638:
5635:
5633:
5630:
5627:
5626:
5624:
5622:
5618:
5611:
5608:
5605:
5604:
5601:
5598:
5596:
5593:
5591:
5588:
5585:
5584:
5582:
5580:
5576:
5570:
5567:
5564:
5563:
5560:
5557:
5555:
5552:
5550:
5547:
5545:
5542:
5539:
5538:
5536:
5534:
5530:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5493:
5492:
5488:
5484:
5480:
5476:
5472:
5468:
5464:
5461:
5458:
5457:
5455:
5453:
5449:
5443:
5440:
5438:
5435:
5432:
5431:
5429:
5427:
5423:
5417:
5414:
5412:
5409:
5407:
5404:
5401:
5400:
5397:
5394:
5392:
5391:Interleukin 4
5389:
5387:
5384:
5382:
5379:
5376:
5375:
5373:
5371:
5367:
5361:
5358:
5356:
5353:
5350:
5349:
5346:
5343:
5341:
5340:Edodekin alfa
5338:
5335:
5334:
5332:
5330:
5326:
5320:
5317:
5315:
5312:
5309:
5308:
5306:
5304:
5300:
5294:
5291:
5289:
5286:
5283:
5282:
5280:
5278:
5274:
5268:
5265:
5262:
5261:
5258:
5257:Interleukin 9
5255:
5252:
5251:
5249:
5247:
5243:
5236:
5232:
5231:
5229:
5227:
5223:
5217:
5216:Interleukin 7
5214:
5211:
5210:
5208:
5206:
5202:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5145:
5144:
5141:
5140:Interleukin 6
5138:
5136:
5135:Atexakin alfa
5133:
5130:
5129:
5127:
5125:
5121:
5115:
5112:
5109:
5108:
5105:
5102:
5100:
5097:
5095:
5092:
5089:
5088:
5085:
5082:
5079:
5078:
5075:
5074:Interleukin 5
5072:
5069:
5068:
5066:
5064:
5060:
5054:
5051:
5049:
5046:
5043:
5042:
5039:
5036:
5033:
5032:
5029:
5026:
5024:
5023:Interleukin 4
5021:
5019:
5016:
5013:
5012:
5010:
5008:
5004:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4977:Interleukin 3
4975:
4973:
4970:
4967:
4966:
4964:
4962:
4958:
4952:
4949:
4947:
4944:
4942:
4939:
4936:
4935:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4916:Interleukin 2
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4891:
4890:
4888:
4886:
4882:
4876:
4873:
4870:
4869:
4866:
4863:
4861:
4858:
4856:
4853:
4850:
4849:
4846:
4843:
4841:
4838:
4836:
4833:
4831:
4828:
4825:
4824:
4821:
4818:
4816:
4813:
4810:
4806:
4802:
4801:Interleukin 1
4799:
4796:
4795:
4793:
4791:
4787:
4783:
4780:
4773:
4768:
4766:
4761:
4759:
4754:
4753:
4750:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4710:
4709:
4702:
4698:
4695:
4693:
4690:
4689:
4688:
4681:
4680:
4679:
4676:
4674:
4671:
4670:
4665:
4662:
4660:
4657:
4656:
4655:
4654:
4650:
4649:
4647:
4641:
4631:
4628:
4626:
4623:
4619:
4616:
4614:
4611:
4610:
4609:
4608:Hematopoietic
4606:
4605:
4603:
4599:
4588:
4584:
4580:
4577:
4576:
4574:
4572:
4568:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4508:
4505:
4504:
4502:
4500:
4496:
4482:
4479:
4478:
4476:
4474:
4470:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4385:
4383:
4381:
4377:
4374:
4372:
4368:
4360:
4357:
4355:
4352:
4351:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4321:
4318:
4317:
4315:
4313:
4309:
4306:
4304:
4300:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4271:
4269:
4265:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4240:
4238:
4236:
4232:
4228:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4201:
4200:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4175:
4173:
4171:
4166:
4160:
4157:
4155:
4152:
4150:
4147:
4146:
4144:
4142:
4138:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4113:
4110:
4108:
4104:
4101:
4100:
4098:
4096:
4092:
4089:
4081:
4077:
4074:
4072:
4068:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4016:TNFSF5/CD40LG
4014:
4012:
4009:
4005:
4002:
4000:
3997:
3996:
3995:
3992:
3990:
3987:
3986:
3984:
3982:
3978:
3968:
3965:
3963:
3960:
3959:
3957:
3953:
3947:
3944:
3943:
3941:
3937:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3850:
3847:
3846:
3844:
3840:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3789:
3786:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3722:
3719:
3716:
3713:
3710:
3707:
3704:
3701:
3699:
3696:
3695:
3693:
3689:
3686:
3684:
3680:
3677:
3673:
3669:
3665:
3658:
3653:
3651:
3646:
3644:
3639:
3638:
3635:
3625:
3621:
3617:
3613:
3609:
3605:
3602:(3): 229–42.
3601:
3597:
3590:
3587:
3582:
3578:
3573:
3568:
3564:
3560:
3556:
3552:
3548:
3541:
3538:
3533:
3529:
3524:
3519:
3515:
3511:
3507:
3500:
3498:
3496:
3492:
3487:
3483:
3478:
3473:
3468:
3463:
3459:
3455:
3451:
3444:
3441:
3436:
3432:
3427:
3422:
3418:
3414:
3411:(3): 351–67.
3410:
3406:
3402:
3395:
3392:
3387:
3383:
3379:
3375:
3371:
3367:
3364:(3): 436–47.
3363:
3359:
3352:
3349:
3344:
3340:
3336:
3332:
3328:
3324:
3320:
3316:
3308:
3305:
3294:on 2015-03-25
3293:
3289:
3283:
3280:
3268:
3262:
3259:
3254:
3250:
3246:
3242:
3238:
3234:
3227:
3224:
3219:
3215:
3211:
3207:
3203:
3199:
3192:
3189:
3184:
3180:
3175:
3170:
3166:
3162:
3158:
3151:
3148:
3143:
3139:
3135:
3131:
3127:
3123:
3116:
3113:
3108:
3104:
3100:
3096:
3092:
3088:
3085:(5): 327–30.
3084:
3080:
3073:
3070:
3065:
3061:
3056:
3051:
3047:
3043:
3039:
3035:
3031:
3024:
3022:
3020:
3018:
3014:
3009:
3005:
3000:
2995:
2992:(7): 4481–9.
2991:
2987:
2983:
2976:
2974:
2970:
2965:
2961:
2956:
2951:
2947:
2943:
2939:
2935:
2931:
2924:
2922:
2920:
2916:
2911:
2907:
2903:
2899:
2895:
2891:
2887:
2880:
2878:
2876:
2874:
2872:
2870:
2866:
2861:
2857:
2852:
2847:
2843:
2839:
2836:(2): 342–50.
2835:
2831:
2827:
2820:
2818:
2814:
2809:
2805:
2801:
2797:
2793:
2789:
2785:
2781:
2777:
2773:
2766:
2764:
2762:
2758:
2753:
2749:
2744:
2739:
2735:
2731:
2727:
2723:
2719:
2712:
2710:
2708:
2706:
2704:
2700:
2695:
2691:
2687:
2683:
2678:
2673:
2669:
2665:
2661:
2654:
2651:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2603:
2601:
2597:
2592:
2588:
2584:
2580:
2575:
2570:
2566:
2562:
2558:
2554:
2550:
2543:
2541:
2537:
2532:
2528:
2523:
2518:
2515:(2): 179–89.
2514:
2510:
2506:
2499:
2497:
2493:
2488:
2484:
2479:
2474:
2469:
2464:
2460:
2456:
2452:
2448:
2444:
2437:
2434:
2429:
2425:
2420:
2415:
2411:
2407:
2403:
2396:
2393:
2388:
2384:
2379:
2374:
2371:(3): 1910–4.
2370:
2366:
2362:
2355:
2352:
2347:
2343:
2338:
2333:
2329:
2325:
2321:
2314:
2312:
2308:
2303:
2299:
2295:
2291:
2287:
2283:
2279:
2275:
2268:
2265:
2260:
2256:
2252:
2248:
2243:
2238:
2234:
2230:
2226:
2219:
2217:
2213:
2208:
2204:
2200:
2196:
2191:
2186:
2182:
2178:
2174:
2167:
2165:
2163:
2159:
2154:
2150:
2145:
2140:
2137:(4): 467–76.
2136:
2132:
2128:
2121:
2119:
2117:
2115:
2113:
2111:
2109:
2105:
2100:
2096:
2091:
2086:
2082:
2078:
2074:
2070:
2066:
2059:
2057:
2055:
2053:
2049:
2044:
2040:
2036:
2032:
2029:(9): 888–98.
2028:
2024:
2017:
2014:
2009:
2005:
2000:
1995:
1992:(3): 677–87.
1991:
1987:
1983:
1976:
1973:
1968:
1964:
1959:
1954:
1950:
1946:
1942:
1935:
1932:
1927:
1923:
1918:
1913:
1909:
1905:
1901:
1894:
1891:
1886:
1882:
1878:
1874:
1870:
1866:
1863:(2): 319–24.
1862:
1858:
1851:
1848:
1843:
1839:
1835:
1831:
1828:(2): 155–74.
1827:
1823:
1816:
1814:
1812:
1810:
1808:
1804:
1799:
1795:
1790:
1785:
1781:
1777:
1773:
1769:
1765:
1758:
1754:
1748:
1746:
1742:
1736:
1734:
1731:
1727:
1723:
1719:
1715:
1709:
1706:
1700:
1695:
1687:
1685:
1683:
1680:cytokines by
1679:
1675:
1671:
1666:
1664:
1658:
1656:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1624:
1616:
1614:
1612:
1608:
1599:
1597:
1594:
1590:
1586:
1582:
1578:
1573:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1539:
1535:
1530:
1528:
1524:
1520:
1515:
1513:
1505:
1503:
1501:
1497:
1493:
1489:
1485:
1484:neurotrophins
1480:
1478:
1474:
1469:
1468:glycosylation
1465:
1461:
1457:
1453:
1445:
1443:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1409:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1371:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1341:
1333:
1331:
1329:
1325:
1321:
1317:
1313:
1309:
1305:
1297:
1293:
1287:
1285:
1284:keratinocytes
1281:
1277:
1273:
1269:
1265:
1264:keratinocytes
1261:
1257:
1253:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1201:
1199:
1197:
1192:
1191:3-dimensional
1188:
1184:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1148:
1146:
1144:
1140:
1139:interleukin-1
1136:
1132:
1128:
1124:
1120:
1116:
1111:
1109:
1108:
1104:
1099:
1094:
1090:
1086:
1083:
1080:
1076:
1072:
1068:
1064:
1060:
1059:T helper cell
1056:
1053:
1049:
1045:
1033:
1030:
1026:
1023:
1020:
1016:
1011:
1007:
1004:
1003:
999:
996:
994:
990:
985:
982:
979:
977:
973:
970:
967:
965:
961:
958:
955:
953:
949:
946:
943:
941:
937:
934:
931:
929:
925:
922:
919:
917:
913:
909:
905:
901:
897:
892:
887:
882:
877:
872:
861:
858:
854:
851:
848:
844:
839:
835:
832:
831:
827:
824:
822:
818:
813:
810:
807:
805:
801:
798:
795:
793:
789:
786:
783:
781:
777:
774:
771:
769:
765:
762:
759:
757:
753:
750:
747:
743:
739:
735:
730:
725:
714:
711:
707:
704:
701:
697:
692:
688:
685:
684:
680:
677:
675:
671:
666:
663:
660:
658:
654:
651:
648:
646:
642:
639:
636:
634:
630:
627:
624:
622:
618:
615:
612:
610:
606:
602:
598:
593:
588:
577:
574:
570:
567:
564:
560:
555:
551:
548:
547:
543:
540:
538:
534:
529:
526:
523:
521:
517:
514:
511:
509:
505:
502:
499:
497:
493:
490:
487:
485:
481:
478:
475:
473:
469:
465:
461:
457:
453:
448:
443:
432:
429:
425:
422:
419:
415:
410:
406:
403:
402:
398:
395:
393:
389:
384:
381:
378:
376:
372:
369:
366:
364:
360:
357:
354:
352:
348:
345:
342:
340:
336:
333:
330:
328:
324:
320:
316:
312:
308:
303:
298:
287:
284:
280:
277:
274:
270:
265:
261:
258:
257:
253:
250:
248:
244:
239:
236:
233:
231:
227:
224:
221:
219:
215:
212:
209:
207:
203:
200:
197:
195:
191:
188:
185:
183:
179:
175:
171:
168:
165:
161:
156:
153:
149:
138:
135:
133:
129:
126:
122:
118:
115:
113:
109:
105:
101:
98:
95:
91:
86:
82:
79:
76:
74:
70:
67:
64:
62:
58:
54:
50:
45:
40:
35:
27:
19:
6058:Interleukins
5999:
5987:M-CSFR/CSF1R
5974:heterodimer)
5960:heterodimer)
5889:Antagonists:
5888:
5860:
5839:
5818:
5778:
5757:
5730:Risankizumab
5711:
5701:
5679:
5669:
5652:NNC0114-0006
5647:NNC0114-0005
5643:
5628:
5606:
5586:
5565:
5540:
5494:
5462:
5459:
5433:
5416:Tralokinumab
5411:Lebrikizumab
5406:Anrukinzumab
5402:
5377:
5351:
5336:
5310:
5284:
5263:
5253:
5212:
5155:Clazakizumab
5146:
5131:
5110:
5094:Benralizumab
5090:
5081:Antagonists:
5080:
5070:
5053:Pascolizumab
5044:
5035:Antagonists:
5034:
5014:
4968:
4937:
4892:
4871:
4851:
4827:Antagonists:
4826:
4797:
4703:
4682:
4651:
4643:By function/
4578:
4354:IL28/IFNL2+3
3599:
3595:
3589:
3554:
3550:
3540:
3513:
3509:
3457:
3453:
3443:
3408:
3404:
3394:
3361:
3357:
3351:
3318:
3314:
3307:
3296:. Retrieved
3292:the original
3282:
3271:. Retrieved
3261:
3239:(6): 453–5.
3236:
3232:
3226:
3204:(6): 511–7.
3201:
3197:
3191:
3167:(2): 463–5.
3164:
3160:
3150:
3128:(5): 383–9.
3125:
3121:
3115:
3082:
3078:
3072:
3037:
3033:
2989:
2985:
2937:
2933:
2893:
2889:
2833:
2829:
2778:(1): 60–76.
2775:
2771:
2725:
2721:
2667:
2663:
2653:
2612:
2608:
2556:
2552:
2512:
2508:
2450:
2446:
2436:
2409:
2405:
2395:
2368:
2364:
2354:
2327:
2323:
2277:
2273:
2267:
2235:(5): 367–9.
2232:
2228:
2180:
2176:
2134:
2130:
2075:(1): 17–26.
2072:
2068:
2026:
2022:
2016:
1989:
1985:
1975:
1951:(2): 642–6.
1948:
1944:
1934:
1907:
1903:
1893:
1860:
1856:
1850:
1825:
1821:
1771:
1767:
1710:
1701:
1697:
1667:
1659:
1641:(trade name
1620:
1603:
1574:
1534:keratinocyte
1531:
1516:
1509:
1488:cystine knot
1481:
1477:interleukins
1460:glycoprotein
1449:
1427:
1411:
1407:
1390:
1374:
1372:
1360:inflammatory
1356:inflammation
1337:
1288:
1205:
1152:
1112:
1105:
1103:rhadinovirus
1093:IL-17 family
1088:
1070:
1052:cystine knot
1047:
1043:
1042:
1000:
907:Alt. symbols
828:
745:Alt. symbols
681:
544:
463:Alt. symbols
399:
318:Alt. symbols
254:
173:Alt. symbols
26:
18:IL 17 family
5740:Ustekinumab
5720:Briakinumab
5712:Antibodies:
5683:Fezakinumab
5680:Antibodies:
5644:Antibodies:
5632:Denenicokin
5607:Antibodies:
5544:Iboctadekin
5523:Vunakizumab
5518:Secukinumab
5508:Perakizumab
5495:Antibodies:
5403:Antibodies:
5360:Ustekinumab
5355:Briakinumab
5352:Antibodies:
5264:Antibodies:
5190:Tocilizumab
5160:Elsilimomab
5147:Antibodies:
5099:Mepolizumab
5091:Antibodies:
5045:Antibodies:
4972:Daniplestim
4941:Basiliximab
4938:Antibodies:
4906:Celmoleukin
4901:Aldesleukin
4865:Lutikizumab
4860:Gevokizumab
4855:Canakinumab
4852:Antibodies:
4571:IL17 family
4312:IL10 family
4231:IL12 family
4083:(grouped by
4071:Interleukin
3994:Lymphotoxin
3557:(1): 8–16.
1655:ustekinumab
1639:secukinumab
1523:hyperplasia
1458:, secreted
1456:homodimeric
1296:T helper 17
1276:T helper 22
1268:macrophages
1252:fibroblasts
1235:(including
1048:IL17 family
1022:Swiss-model
894:Identifiers
850:Swiss-model
732:Identifiers
703:Swiss-model
595:Identifiers
566:Swiss-model
450:Identifiers
421:Swiss-model
305:Identifiers
276:Swiss-model
176:IL17, CTLA8
158:Identifiers
47:Identifiers
6027:Categories
5795:B (IFN-λ3)
5791:A (IFN-λ2)
5725:Guselkumab
5715:Brazikumab
5610:Fletikumab
5513:Remtolumab
5503:Ixekizumab
5498:Brodalumab
5381:Binetrakin
5319:Oprelvekin
5288:Ilodecakin
5267:Enokizumab
5180:Siltuximab
5170:Olokizumab
5104:Reslizumab
5038:Pitrakinra
5018:Binetrakin
4987:Milodistim
4982:Leridistim
4951:Inolimomab
4926:Teceleukin
4845:Isunakinra
4782:modulators
4678:Lymphokine
4516:IL1B/IL1F2
4511:IL1A/IL1F1
4507:IL1 family
4371:Interferon
4359:IL29/IFNL1
3551:Immunology
3298:2015-03-12
3273:2015-03-12
2728:: 227–55.
2280:: 101610.
2183:(1): 1–8.
1737:References
1692:See also:
1554:chemotaxis
1348:expression
1344:base pairs
1233:chemokines
1131:chemokines
1075:transcript
1018:Structures
1013:Search for
987:Other data
846:Structures
841:Search for
815:Other data
699:Structures
694:Search for
668:Other data
562:Structures
557:Search for
531:Other data
417:Structures
412:Search for
386:Other data
272:Structures
267:Search for
241:Other data
100:structures
6000:Unsorted:
5861:Agonists:
5840:Agonists:
5819:Agonists:
5779:Agonists:
5758:Agonists:
5702:Agonists:
5670:Agonists:
5629:Agonists:
5587:Agonists:
5559:Tadekinig
5541:Agonists:
5460:Agonists:
5434:Agonists:
5378:Agonists:
5337:Agonists:
5311:Agonists:
5285:Agonists:
5254:Agonists:
5213:Agonists:
5195:Levilimab
5185:Sirukumab
5175:Sarilumab
5132:Agonists:
5071:Agonists:
5048:Dupilumab
5015:Agonists:
4992:Muplestim
4969:Agonists:
4893:Agonists:
4820:Pifonakin
4815:Mobenakin
4798:Agonists:
4556:33/IL1F11
4521:1Ra/IL1F3
4168:IL6 like/
3885:CXCL8/IL8
3683:Chemokine
3675:By family
3668:cytokines
2896:(10): 1.
1885:205257996
1760:;
1688:Receptors
1670:vitamin D
1631:psoriasis
1566:monocytes
1542:TNF-alpha
1512:psoriasis
1492:β-strands
1454:-linked,
1452:disulfide
1446:Structure
1434:specific
1320:psoriasis
1316:allograft
1143:psoriasis
1085:hybridoma
1061:known as
1055:cytokines
969:NP_443104
916:NCBI gene
797:NP_073626
756:NCBI gene
650:NP_612141
609:NCBI gene
513:NP_037410
472:NCBI gene
368:NP_055258
327:NCBI gene
223:NP_002181
182:NCBI gene
78:IPR010345
55:IL-17_fam
5954:IL-22Rα1
5920:instead.
5237:instead.
5165:mAb 1339
5150:ARGX-109
5114:TPI ASM8
5084:YM-90709
4835:Anakinra
4830:AF-12198
4673:Monokine
4202:+non IL
4087:subunit)
4085:receptor
4056:TNFSF13B
4004:TNFC/LTB
3999:TNFB/LTA
3624:22008293
3616:16891673
3581:21726218
3532:15577820
3486:20974859
3435:25667306
3386:10722525
3378:23370232
3343:24055733
3335:18486739
3142:20025586
3107:24119451
3099:22509827
3064:22677045
3008:21346238
2964:21606249
2910:23122008
2860:25585875
2830:Cytokine
2808:20349222
2800:21155836
2752:24655295
2686:16990136
2637:16648838
2583:16648837
2531:16473830
2509:Immunity
2487:16698929
2428:16622035
2387:12417590
2302:85495400
2294:30923023
2259:45530740
2207:15271840
2199:11781375
2153:15485625
2131:Immunity
2099:22673731
2043:19710487
2008:21085185
1967:12097364
1877:19016708
1842:12651226
1798:11574464
1643:Cosentyx
1625:such as
1408:in vitro
1403:promoter
1202:Function
1187:cysteine
1032:InterPro
860:InterPro
713:InterPro
576:InterPro
431:InterPro
286:InterPro
117:RCSB PDB
73:InterPro
5972:IL-10Rβ
5968:IL-20Rα
5958:IL-20Rβ
5892:IL-36RA
5437:ALT-803
4561:18/IL1G
4303:Type II
4235:IL12RB1
4141:β chain
4095:γ chain
4051:TNFSF13
4046:TNFSF11
4041:TNFSF10
3723:/RANTES
3572:3173690
3477:2998156
3426:4354367
3253:3312283
3218:4168861
3183:4016279
3055:3470466
2955:3119764
2851:4437803
2780:Bibcode
2743:4229247
2694:9034013
2645:4391497
2617:Bibcode
2591:4379904
2561:Bibcode
2478:1459629
2455:Bibcode
2346:7499828
2251:2189615
2090:3568997
1926:8390535
1724:, p38,
1684:cells.
1558:T cells
1486:. The
1424:T-cells
1412:in vivo
1366:and in
1352:T cells
1243:(e.g.,
1196:mammals
1183:protein
1077:from a
1028:Domains
976:UniProt
856:Domains
826:Chr. 14
804:UniProt
709:Domains
679:Chr. 13
657:UniProt
572:Domains
542:Chr. 16
520:UniProt
427:Domains
375:UniProt
282:Domains
230:UniProt
66:PF06083
5928:Others
5901:Others
5853:IL1RL2
5832:IL1RL1
5569:IL18BP
4840:IL-1RA
4551:IL1F10
4448:IFNA21
4443:IFNA17
4438:IFNA16
4433:IFNA14
4428:IFNA13
4423:IFNA10
4080:Type I
4036:TNFSF9
4031:TNFSF8
4026:TNFSF7
4021:TNFSF6
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1098:O40633
1082:T-cell
1079:rodent
1071:et al.
998:Chr. 6
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964:RefSeq
945:606496
921:112744
899:Symbol
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785:605658
737:Symbol
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600:Symbol
525:Q9P0M4
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