1378:
recurrent disease. Because expression in gonadal and various extragonadal tissues may vary several fold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
344:
321:
218:
243:
602:
595:
4027:
4057:
4042:
4072:
4117:
350:
249:
4102:
31:
4087:
1377:
secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as
57:
2378:
1538:
Lewis KA, Gray P C, Blount A L, MacConell L A, Wiater E, Bilezikjian L M, Vale W (March 2000). "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling".
2300:
ten Dijke P, Ichijo H, Franzén P, et al. (1993). "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity".
2371:
357:
256:
2364:
1693:
Welt C, Sidis Y, Keutmann H, Schneyer A (2002). "Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium".
1080:
4026:
1061:
179:
4056:
4041:
4071:
3936:
4116:
4006:
1471:
1453:
4145:
2242:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
4101:
2135:
Sumitomo S, Inouye S, Liu XJ, et al. (1995). "The heparin binding site of follistatin is involved in its interaction with activin".
343:
54:
1291:
1284:
320:
1524:
3855:
3281:
2925:
2621:
2476:
1440:
1419:
1882:
Tanimoto K, Handa S, Ueno N, et al. (1992). "Structure and sequence analysis of the human activin beta A subunit gene".
1436:
242:
217:
3687:
3523:
3388:
3271:
3173:
3099:
2911:
2802:
2466:
1415:
3813:
3723:
3659:
3479:
3356:
3244:
3055:
2701:
2401:
2387:
1948:"Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice"
1374:
159:
1601:"Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells"
1387:
4086:
356:
255:
3655:
3475:
3352:
3051:
2697:
2590:
2451:
1845:
Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase".
349:
248:
3999:
3799:
2692:
2580:
1125:
167:
1608:
1599:
Martens JW, de Winter J P, Timmerman M A, McLuskey A, van Schaik R H, Themmen A P, de Jong F H (July 1997).
1106:
1489:
Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances".
3992:
1994:
1549:
231:
2034:
Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances".
146:
3946:
1362:
3140:
2751:
2654:
1983:"Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain"
1246:
3896:
3771:
2534:
2393:
2230:
2166:"Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism"
2123:
1870:
1798:
1761:
1718:
1581:
191:
3728:
3571:
3410:
3125:
1267:
1242:
1216:
1195:
3329:
3230:
3018:
3013:
2983:
2978:
2878:
2323:"Human activin betaA gene. Identification of novel 5' exon, functional promoter, and enhancers"
1828:
1811:
3921:
2998:
2461:
2344:
2309:
2288:
2259:
2222:
2187:
2152:
2115:
2080:
2051:
2022:
1969:
1934:
1899:
1862:
1833:
1790:
1753:
1710:
1681:
1635:
1627:
1573:
1565:
1506:
601:
139:
47:
3220:
3145:
2968:
2868:
2756:
2659:
2509:
3941:
3931:
3023:
2973:
2664:
2514:
2334:
2280:
2251:
2212:
2177:
2144:
2105:
2072:
2043:
2012:
2002:
1959:
1924:
1891:
1854:
1823:
1782:
1773:
Reis FM, Luisi S, Carneiro MM, et al. (2005). "Activin, inhibin and the human breast".
1743:
1702:
1671:
1617:
1557:
1540:
1498:
436:
367:
311:
266:
3324:
3135:
2746:
2649:
2644:
594:
187:
3752:
3682:
3677:
3595:
3518:
3513:
3383:
3378:
3201:
3094:
3089:
2849:
2736:
2731:
2616:
411:
1998:
1553:
2356:
1812:"Effect of activin A on globin gene expression in purified human erythroid progenitors"
30:
2017:
1982:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
4139:
3906:
2499:
2255:
2110:
2093:
2076:
1964:
1947:
1858:
630:
2127:
1874:
1802:
1765:
1722:
3926:
3309:
3304:
2993:
2953:
2948:
2524:
2234:
1585:
429:
208:
2271:
Nishihara T, Okahashi N, Ueda N (1994). "Activin A induces apoptotic cell death".
2063:
Mason AJ, Niall HD, Seeburg PH (1986). "Structure of two human ovarian inhibins".
171:
856:
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
195:
3916:
3614:
3314:
2958:
1476:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1458:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1748:
1731:
1706:
512:
3956:
3867:
3863:
3859:
3649:
3469:
3293:
3289:
3285:
2988:
2937:
2933:
2929:
2796:
2633:
2629:
2625:
2574:
2488:
2484:
2480:
2440:
1895:
1786:
1525:"Entrez Gene: INHBA inhibin, beta A (activin A, activin AB alpha polypeptide)"
328:
225:
175:
2339:
2322:
2217:
2200:
1631:
1569:
3849:
3845:
3836:
3746:
3742:
3713:
3645:
3641:
3589:
3585:
3561:
3465:
3461:
3428:
3424:
3266:
3225:
3008:
2906:
2873:
2843:
2839:
2820:
2792:
2788:
2585:
2570:
2566:
2446:
2436:
2432:
2182:
2165:
2047:
1622:
1600:
1502:
1025:
572:
450:
395:
382:
294:
281:
183:
3822:
3253:
2284:
2148:
2007:
1913:"Activin B: precursor sequences, genomic structure and in vitro activities"
1794:
1757:
1714:
1685:
1577:
2348:
2313:
2292:
2263:
2226:
2191:
2156:
2119:
2084:
2055:
2026:
1973:
1938:
1929:
1912:
1903:
1866:
1837:
1676:
1659:
1639:
1510:
1331:
1326:
150:, EDF, FRP, inhibin beta A, inhibin beta A subunit, inhibin subunit beta A
3973:
1315:
1170:
1151:
3911:
3901:
3841:
3738:
3637:
3581:
3457:
3420:
2835:
2784:
2562:
2428:
1373:
The inhibin beta A subunit joins the alpha subunit to form a pituitary
1351:
1137:
1092:
1365:, two closely related glycoproteins with opposing biological effects.
836:
positive regulation of pathway-restricted SMAD protein phosphorylation
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
3962:
3760:
3756:
3624:
3603:
3599:
3439:
3209:
3205:
3003:
2857:
2853:
1561:
1391:
1299:
1047:
3038:
2679:
3891:
3823:
3781:
3718:
3566:
3555:
3551:
3507:
3503:
3499:
3372:
3340:
3339:
3275:
3254:
3191:
3185:
3119:
3083:
3079:
3075:
2919:
2915:
2893:
2825:
2814:
2725:
2721:
2610:
2606:
2455:
1010:
1006:
4035:: Crystal Structure of Activin A Bound to the ECD of ActRIIB P41
3707:
3703:
3699:
3695:
3691:
3671:
3667:
3663:
3547:
3543:
3539:
3535:
3531:
3527:
3495:
3491:
3487:
3483:
3404:
3400:
3396:
3392:
3368:
3364:
3360:
3181:
3177:
3155:
3115:
3111:
3107:
3103:
3071:
3067:
3063:
3059:
3033:
2888:
2810:
2806:
2766:
2717:
2713:
2709:
2705:
2674:
2602:
2598:
2594:
2544:
2470:
2410:
1358:
163:
4065:: Crystal structure of the activin/actrIIb extracellular domain
3988:
2360:
610:
3984:
3782:
2094:"Human inhibin genes. Genomic characterisation and sequencing"
826:
positive regulation of follicle-stimulating hormone secretion
761:
negative regulation of follicle-stimulating hormone secretion
4050:: Crystal Structure of Activin A Bound to the ECD of ActRIIB
2201:"Functional analysis of the cysteine residues of activin A"
1911:
Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990).
916:
cellular response to follicle-stimulating hormone stimulus
931:
positive regulation of transcription by RNA polymerase II
4080:: Activin A in complex with Fs12 fragment of follistatin
419:
3786:
2388:
2092:
Stewart AG, Milborrow HM, Ring JM, et al. (1986).
1946:
Barton DE, Yang-Feng TL, Mason AJ, et al. (1989).
4125:: The structure of the Activin:Follistatin 315 complex
3156:
3034:
2889:
2767:
2675:
2545:
2415:
2411:
584:
1732:"The role of activin a in regulation of hemopoiesis"
1660:"A novel role of activin in inflammation and repair"
966:
regulation of follicle-stimulating hormone secretion
746:
negative regulation of cell population proliferation
3881:
3821:
3812:
3780:
3623:
3438:
3338:
3252:
3243:
3154:
3032:
2887:
2765:
2673:
2543:
2409:
2400:
2321:Tanimoto K, Yoshida E, Mita S, et al. (1997).
2164:Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995).
1260:
1235:
1209:
1188:
896:
positive regulation of transcription, DNA-templated
4110:: The Structure of the Follistatin:Activin Complex
3160:
2771:
2549:
1432:
1430:
1428:
1411:
1409:
1407:
911:positive regulation of erythrocyte differentiation
1810:Shao L, Frigon NL, Young AL, et al. (1992).
1658:Munz B, Hübner G, Tretter Y, et al. (1999).
786:negative regulation of macrophage differentiation
366:
265:
3625:
3440:
991:negative regulation of hair follicle development
891:positive regulation of protein metabolic process
806:regulation of transcription by RNA polymerase II
644:transforming growth factor beta receptor binding
3444:
1981:Murata M, Eto Y, Shibai H, et al. (1988).
16:Protein-coding gene in the species Homo sapiens
1437:GRCm38: Ensembl release 89: ENSMUSG00000041324
4000:
2372:
876:negative regulation of B cell differentiation
801:hematopoietic progenitor cell differentiation
8:
886:striatal medium spiny neuron differentiation
1416:GRCh38: Ensembl release 89: ENSG00000122641
4007:
3993:
3985:
3818:
3249:
2406:
2379:
2365:
2357:
1829:10.1182/blood.V79.3.773.bloodjournal793773
1021:
626:
407:
306:
203:
65:
2338:
2216:
2181:
2109:
2016:
2006:
1963:
1928:
1827:
1747:
1675:
1621:
971:regulation of signaling receptor activity
4022:
1403:
831:cell surface receptor signaling pathway
851:positive regulation of gene expression
811:negative regulation of phosphorylation
20:
976:G1/S transition of mitotic cell cycle
821:extrinsic apoptotic signaling pathway
751:eyelid development in camera-type eye
371:
332:
327:
270:
229:
224:
7:
674:protein heterodimerization activity
3889:Endogenous antagonists/inhibitors:
1354:which in humans is encoded by the
1257:
1232:
1206:
1185:
1161:
1142:
1116:
1097:
1071:
1052:
941:negative regulation of cell growth
871:activin receptor signaling pathway
589:
507:
445:
424:
14:
936:negative regulation of cell cycle
4115:
4100:
4085:
4070:
4055:
4040:
4025:
861:cellular response to cholesterol
846:positive regulation of ovulation
816:SMAD protein signal transduction
766:GABAergic neuron differentiation
679:type II activin receptor binding
600:
593:
355:
348:
342:
319:
254:
247:
241:
216:
29:
986:regulation of apoptotic process
901:hemoglobin biosynthetic process
781:mesodermal cell differentiation
756:endodermal cell differentiation
720:perinuclear region of cytoplasm
4095:: Structure of human Activin A
2665:ML-347 (LDN-193719, VU0469381)
2515:ML-347 (LDN-193719, VU0469381)
611:More reference expression data
573:More reference expression data
1:
2273:Biochem. Biophys. Res. Commun
2137:Biochem. Biophys. Res. Commun
2065:Biochem. Biophys. Res. Commun
1730:Shav-Tal Y, Zipori D (2003).
1616:(7). UNITED STATES: 2928–36.
1361:. INHBA is a subunit of both
340:
239:
2256:10.1016/0378-1119(94)90802-8
2111:10.1016/0014-5793(86)81006-7
2077:10.1016/0006-291X(86)91021-1
1987:Proc. Natl. Acad. Sci. U.S.A
1965:10.1016/0888-7543(89)90091-8
1859:10.1016/0092-8674(91)90549-E
881:ovarian follicle development
4146:Genes on human chromosome 7
3004:RepSox (E-616452, SJN-2511)
956:erythrocyte differentiation
477:stromal cell of endometrium
4162:
1749:10.1634/stemcells.20-6-493
1707:10.1177/153537020222700905
921:regulation of MAPK cascade
841:nervous system development
649:signaling receptor binding
4020:
2994:Galunisertib (LY-2157299)
1896:10.3109/10425179109039678
1787:10.1016/j.mce.2004.02.016
1695:Exp. Biol. Med. (Maywood)
1472:"Mouse PubMed Reference:"
1454:"Human PubMed Reference:"
1330:
1325:
1321:
1314:
1298:
1279:
1264:
1239:
1228:
1213:
1192:
1181:
1168:
1164:
1149:
1145:
1136:
1123:
1119:
1104:
1100:
1091:
1078:
1074:
1059:
1055:
1046:
1031:
1024:
1020:
1004:
906:roof of mouth development
796:hair follicle development
659:identical protein binding
629:
625:
608:
592:
583:
570:
519:
510:
457:
448:
418:
410:
406:
389:
376:
339:
318:
309:
305:
288:
275:
238:
215:
206:
202:
157:
154:
144:
137:
132:
73:
68:
51:
46:
41:
37:
28:
23:
3942:Thrombospondin 1 (THBS1)
3724:Osteogenin (BMP3, BMP3A)
2340:10.1074/jbc.271.51.32760
2218:10.1210/mend.8.3.8015550
1548:(6776). ENGLAND: 411–4.
1386:INHBA has been shown to
1292:Chr 13: 16.19 – 16.21 Mb
2183:10.1074/jbc.270.11.6308
2048:10.1210/endo-122-4-1701
1623:10.1210/endo.138.7.5250
1503:10.1210/endo-122-4-1701
1285:Chr 7: 41.67 – 41.71 Mb
684:peptide hormone binding
3141:Dorsomorphin (BML-275)
2752:Dorsomorphin (BML-275)
2655:Dorsomorphin (BML-275)
2285:10.1006/bbrc.1993.2576
2149:10.1006/bbrc.1995.1297
2008:10.1073/pnas.85.8.2434
961:male gonad development
776:progesterone secretion
664:growth factor activity
1930:10.1210/mend-3-9-1352
1775:Mol. Cell. Endocrinol
1677:10.1677/joe.0.1610187
373:13 A1|13 5.85 cM
334:Chromosome 13 (mouse)
2391:receptor superfamily
981:response to wounding
946:cell differentiation
725:extracellular region
232:Chromosome 7 (human)
69:List of PDB id codes
42:Available structures
3959:(against myostatin)
1999:1988PNAS...85.2434M
1554:2000Natur.404..411L
1363:activin and inhibin
996:signal transduction
771:cell-cell signaling
730:extracellular space
3965:(against endoglin)
3322:Kinase inhibitors:
3218:Kinase inhibitors:
3133:Kinase inhibitors:
2966:Kinase inhibitors:
2866:Kinase inhibitors:
2744:Kinase inhibitors:
2642:Kinase inhibitors:
2507:Kinase inhibitors:
1126:ENSMUSG00000041324
866:mesoderm formation
739:Biological process
703:Cellular component
637:Molecular function
527:epithelium of lens
497:lower lobe of lung
481:buccal mucosa cell
4133:
4132:
3982:
3981:
3877:
3876:
3808:
3807:
3239:
3238:
2532:Other inhibitors:
2199:Mason AJ (1994).
2176:(11): 6308–6313.
1341:
1340:
1337:
1336:
1310:
1309:
1275:
1274:
1254:
1253:
1224:
1223:
1203:
1202:
1177:
1176:
1158:
1157:
1132:
1131:
1113:
1112:
1087:
1086:
1068:
1067:
1016:
1015:
715:activin A complex
710:inhibin A complex
669:cytokine activity
621:
620:
617:
616:
579:
578:
566:
565:
504:
503:
402:
401:
301:
300:
196:INHBA - orthologs
128:
127:
124:
123:
52:Ortholog search:
4153:
4119:
4104:
4089:
4074:
4059:
4044:
4029:
4009:
4002:
3995:
3986:
3825:
3819:
3788:
3784:
3769:Decoy receptors:
3714:Myostatin (GDF8)
3627:
3612:Decoy receptors:
3562:Myostatin (GDF8)
3446:
3442:
3342:
3256:
3250:
3162:
3158:
3040:
3036:
2895:
2891:
2821:Myostatin (GDF8)
2773:
2769:
2681:
2677:
2551:
2547:
2522:Decoy receptors:
2417:
2413:
2407:
2390:
2381:
2374:
2367:
2358:
2352:
2342:
2317:
2296:
2267:
2238:
2220:
2195:
2185:
2160:
2131:
2113:
2088:
2059:
2030:
2020:
2010:
1977:
1967:
1942:
1932:
1907:
1878:
1841:
1831:
1806:
1769:
1751:
1726:
1689:
1679:
1644:
1643:
1625:
1605:
1596:
1590:
1589:
1562:10.1038/35006129
1535:
1529:
1528:
1521:
1515:
1514:
1486:
1480:
1479:
1468:
1462:
1461:
1450:
1444:
1434:
1423:
1413:
1346:, also known as
1323:
1322:
1294:
1287:
1270:
1258:
1249:
1233:
1229:RefSeq (protein)
1219:
1207:
1198:
1186:
1162:
1143:
1117:
1098:
1072:
1053:
1022:
951:defense response
926:cell development
654:hormone activity
627:
613:
604:
597:
590:
575:
551:efferent ductule
515:
513:Top expressed in
508:
493:caput epididymis
461:cartilage tissue
453:
451:Top expressed in
446:
425:
408:
398:
385:
374:
359:
352:
346:
335:
323:
307:
297:
284:
273:
258:
251:
245:
234:
220:
204:
198:
149:
142:
119:
66:
60:
39:
38:
33:
21:
4161:
4160:
4156:
4155:
4154:
4152:
4151:
4150:
4136:
4135:
4134:
4129:
4126:
4120:
4111:
4105:
4096:
4090:
4081:
4075:
4066:
4060:
4051:
4045:
4036:
4030:
4016:
4013:
3983:
3978:
3897:Cerberus (CER1)
3873:
3804:
3776:
3683:Eptotermin alfa
3678:Dibotermin alfa
3619:
3519:Eptotermin alfa
3514:Dibotermin alfa
3434:
3384:Eptotermin alfa
3379:Dibotermin alfa
3334:
3235:
3150:
3095:Eptotermin alfa
3090:Dibotermin alfa
3028:
2883:
2761:
2737:Eptotermin alfa
2732:Dibotermin alfa
2669:
2617:Eptotermin alfa
2539:
2396:
2385:
2355:
2333:(51): 32760–9.
2320:
2308:(10): 2879–87.
2299:
2270:
2241:
2205:Mol. Endocrinol
2198:
2163:
2134:
2091:
2062:
2033:
1980:
1945:
1917:Mol. Endocrinol
1910:
1881:
1844:
1809:
1772:
1729:
1692:
1657:
1653:
1651:Further reading
1648:
1647:
1603:
1598:
1597:
1593:
1537:
1536:
1532:
1523:
1522:
1518:
1488:
1487:
1483:
1470:
1469:
1465:
1452:
1451:
1447:
1435:
1426:
1414:
1405:
1400:
1384:
1371:
1344:Inhibin, beta A
1332:View/Edit Mouse
1327:View/Edit Human
1290:
1283:
1280:Location (UCSC)
1266:
1245:
1241:
1215:
1194:
1107:ENSG00000122641
1000:
734:
698:
694:inhibin binding
689:protein binding
609:
599:
598:
571:
562:
557:
553:
549:
545:
543:dental follicle
541:
539:ascending aorta
537:
533:
529:
525:
511:
500:
495:
491:
487:
483:
479:
475:
473:visceral pleura
471:
467:
463:
449:
393:
380:
372:
362:
361:
360:
353:
333:
310:Gene location (
292:
279:
271:
261:
260:
259:
252:
230:
207:Gene location (
158:
145:
138:
75:
53:
17:
12:
11:
5:
4159:
4157:
4149:
4148:
4138:
4137:
4131:
4130:
4128:
4127:
4121:
4114:
4112:
4106:
4099:
4097:
4091:
4084:
4082:
4076:
4069:
4067:
4061:
4054:
4052:
4046:
4039:
4037:
4031:
4024:
4021:
4018:
4017:
4014:
4012:
4011:
4004:
3997:
3989:
3980:
3979:
3977:
3976:
3967:
3966:
3960:
3950:
3949:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
3894:
3885:
3883:
3879:
3878:
3875:
3874:
3872:
3871:
3853:
3839:
3830:
3828:
3816:
3810:
3809:
3806:
3805:
3803:
3802:
3793:
3791:
3778:
3777:
3775:
3774:
3765:
3764:
3750:
3732:
3731:
3726:
3721:
3716:
3711:
3685:
3680:
3675:
3653:
3631:
3629:
3621:
3620:
3618:
3617:
3608:
3607:
3593:
3575:
3574:
3569:
3564:
3559:
3521:
3516:
3511:
3473:
3451:
3449:
3436:
3435:
3433:
3432:
3414:
3413:
3408:
3386:
3381:
3376:
3346:
3344:
3336:
3335:
3333:
3332:
3327:
3318:
3317:
3312:
3307:
3298:
3297:
3279:
3269:
3260:
3258:
3247:
3241:
3240:
3237:
3236:
3234:
3233:
3228:
3223:
3214:
3213:
3195:
3194:
3189:
3167:
3165:
3152:
3151:
3149:
3148:
3143:
3138:
3129:
3128:
3123:
3097:
3092:
3087:
3045:
3043:
3030:
3029:
3027:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2962:
2961:
2956:
2951:
2942:
2941:
2923:
2909:
2900:
2898:
2885:
2884:
2882:
2881:
2876:
2871:
2862:
2861:
2847:
2829:
2828:
2823:
2818:
2800:
2778:
2776:
2763:
2762:
2760:
2759:
2754:
2749:
2740:
2739:
2734:
2729:
2695:
2686:
2684:
2671:
2670:
2668:
2667:
2662:
2657:
2652:
2647:
2638:
2637:
2619:
2614:
2588:
2583:
2578:
2556:
2554:
2541:
2540:
2538:
2537:
2528:
2527:
2518:
2517:
2512:
2503:
2502:
2493:
2492:
2474:
2464:
2459:
2449:
2444:
2422:
2420:
2404:
2398:
2397:
2386:
2384:
2383:
2376:
2369:
2361:
2354:
2353:
2318:
2297:
2268:
2250:(1–2): 171–4.
2239:
2196:
2161:
2132:
2089:
2060:
2031:
1978:
1943:
1908:
1879:
1842:
1807:
1781:(1–2): 77–82.
1770:
1742:(6): 493–500.
1727:
1690:
1654:
1652:
1649:
1646:
1645:
1591:
1530:
1516:
1481:
1463:
1445:
1424:
1402:
1401:
1399:
1396:
1383:
1380:
1370:
1367:
1339:
1338:
1335:
1334:
1329:
1319:
1318:
1312:
1311:
1308:
1307:
1305:
1303:
1296:
1295:
1288:
1281:
1277:
1276:
1273:
1272:
1262:
1261:
1255:
1252:
1251:
1237:
1236:
1230:
1226:
1225:
1222:
1221:
1211:
1210:
1204:
1201:
1200:
1190:
1189:
1183:
1179:
1178:
1175:
1174:
1166:
1165:
1159:
1156:
1155:
1147:
1146:
1140:
1134:
1133:
1130:
1129:
1121:
1120:
1114:
1111:
1110:
1102:
1101:
1095:
1089:
1088:
1085:
1084:
1076:
1075:
1069:
1066:
1065:
1057:
1056:
1050:
1044:
1043:
1038:
1033:
1029:
1028:
1018:
1017:
1014:
1013:
1002:
1001:
999:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
742:
740:
736:
735:
733:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
640:
638:
634:
633:
623:
622:
619:
618:
615:
614:
606:
605:
587:
581:
580:
577:
576:
568:
567:
564:
563:
561:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
517:
516:
505:
502:
501:
499:
498:
494:
490:
486:
482:
478:
474:
470:
466:
465:saphenous vein
462:
458:
455:
454:
442:
441:
433:
422:
416:
415:
412:RNA expression
404:
403:
400:
399:
391:
387:
386:
378:
375:
370:
364:
363:
354:
347:
341:
337:
336:
331:
325:
324:
316:
315:
303:
302:
299:
298:
290:
286:
285:
277:
274:
269:
263:
262:
253:
246:
240:
236:
235:
228:
222:
221:
213:
212:
200:
199:
156:
152:
151:
143:
135:
134:
130:
129:
126:
125:
122:
121:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
4158:
4147:
4144:
4143:
4141:
4124:
4118:
4113:
4109:
4103:
4098:
4094:
4088:
4083:
4079:
4073:
4068:
4064:
4058:
4053:
4049:
4043:
4038:
4034:
4028:
4023:
4019:
4010:
4005:
4003:
3998:
3996:
3991:
3990:
3987:
3975:
3972:
3969:
3968:
3964:
3961:
3958:
3955:
3952:
3951:
3948:
3947:Tomoregulin 1
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3922:Gremlin (Drm)
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3887:
3886:
3884:
3880:
3869:
3865:
3861:
3857:
3854:
3851:
3847:
3843:
3840:
3838:
3835:
3832:
3831:
3829:
3827:
3820:
3817:
3815:
3811:
3801:
3798:
3795:
3794:
3792:
3790:
3779:
3773:
3770:
3767:
3766:
3762:
3758:
3754:
3751:
3748:
3744:
3740:
3737:
3734:
3733:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3709:
3705:
3701:
3697:
3693:
3689:
3686:
3684:
3681:
3679:
3676:
3673:
3669:
3665:
3661:
3657:
3654:
3651:
3647:
3643:
3639:
3636:
3633:
3632:
3630:
3628:
3622:
3616:
3613:
3610:
3609:
3605:
3601:
3597:
3594:
3591:
3587:
3583:
3580:
3577:
3576:
3573:
3570:
3568:
3565:
3563:
3560:
3557:
3553:
3549:
3545:
3541:
3537:
3533:
3529:
3525:
3522:
3520:
3517:
3515:
3512:
3509:
3505:
3501:
3497:
3493:
3489:
3485:
3481:
3477:
3474:
3471:
3467:
3463:
3459:
3456:
3453:
3452:
3450:
3448:
3437:
3430:
3426:
3422:
3419:
3416:
3415:
3412:
3409:
3406:
3402:
3398:
3394:
3390:
3387:
3385:
3382:
3380:
3377:
3374:
3370:
3366:
3362:
3358:
3354:
3351:
3348:
3347:
3345:
3343:
3337:
3331:
3328:
3326:
3323:
3320:
3319:
3316:
3313:
3311:
3308:
3306:
3303:
3300:
3299:
3295:
3291:
3287:
3283:
3280:
3277:
3273:
3270:
3268:
3265:
3262:
3261:
3259:
3257:
3251:
3248:
3246:
3242:
3232:
3229:
3227:
3224:
3222:
3219:
3216:
3215:
3211:
3207:
3203:
3200:
3197:
3196:
3193:
3190:
3187:
3183:
3179:
3175:
3172:
3169:
3168:
3166:
3164:
3153:
3147:
3144:
3142:
3139:
3137:
3134:
3131:
3130:
3127:
3124:
3121:
3117:
3113:
3109:
3105:
3101:
3098:
3096:
3093:
3091:
3088:
3085:
3081:
3077:
3073:
3069:
3065:
3061:
3057:
3053:
3050:
3047:
3046:
3044:
3042:
3031:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2964:
2963:
2960:
2957:
2955:
2952:
2950:
2947:
2944:
2943:
2939:
2935:
2931:
2927:
2924:
2921:
2917:
2913:
2910:
2908:
2905:
2902:
2901:
2899:
2897:
2886:
2880:
2877:
2875:
2872:
2870:
2867:
2864:
2863:
2859:
2855:
2851:
2848:
2845:
2841:
2837:
2834:
2831:
2830:
2827:
2824:
2822:
2819:
2816:
2812:
2808:
2804:
2801:
2798:
2794:
2790:
2786:
2783:
2780:
2779:
2777:
2775:
2764:
2758:
2755:
2753:
2750:
2748:
2745:
2742:
2741:
2738:
2735:
2733:
2730:
2727:
2723:
2719:
2715:
2711:
2707:
2703:
2699:
2696:
2694:
2691:
2688:
2687:
2685:
2683:
2672:
2666:
2663:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2640:
2639:
2635:
2631:
2627:
2623:
2620:
2618:
2615:
2612:
2608:
2604:
2600:
2596:
2592:
2589:
2587:
2584:
2582:
2579:
2576:
2572:
2568:
2564:
2561:
2558:
2557:
2555:
2553:
2542:
2536:
2533:
2530:
2529:
2526:
2523:
2520:
2519:
2516:
2513:
2511:
2508:
2505:
2504:
2501:
2500:Ascrinvacumab
2498:
2495:
2494:
2490:
2486:
2482:
2478:
2475:
2472:
2468:
2465:
2463:
2460:
2457:
2453:
2450:
2448:
2445:
2442:
2438:
2434:
2430:
2427:
2424:
2423:
2421:
2419:
2408:
2405:
2403:
2399:
2395:
2392:
2382:
2377:
2375:
2370:
2368:
2363:
2362:
2359:
2350:
2346:
2341:
2336:
2332:
2328:
2327:J. Biol. Chem
2324:
2319:
2315:
2311:
2307:
2303:
2298:
2294:
2290:
2286:
2282:
2279:(2): 985–91.
2278:
2274:
2269:
2265:
2261:
2257:
2253:
2249:
2245:
2240:
2236:
2232:
2228:
2224:
2219:
2214:
2211:(3): 325–32.
2210:
2206:
2202:
2197:
2193:
2189:
2184:
2179:
2175:
2171:
2170:J. Biol. Chem
2167:
2162:
2158:
2154:
2150:
2146:
2142:
2138:
2133:
2129:
2125:
2121:
2117:
2112:
2107:
2104:(2): 329–34.
2103:
2099:
2095:
2090:
2086:
2082:
2078:
2074:
2071:(3): 957–64.
2070:
2066:
2061:
2057:
2053:
2049:
2045:
2042:(4): 1701–2.
2041:
2037:
2036:Endocrinology
2032:
2028:
2024:
2019:
2014:
2009:
2004:
2000:
1996:
1993:(8): 2434–8.
1992:
1988:
1984:
1979:
1975:
1971:
1966:
1961:
1957:
1953:
1949:
1944:
1940:
1936:
1931:
1926:
1923:(9): 1352–8.
1922:
1918:
1914:
1909:
1905:
1901:
1897:
1893:
1890:(2): 103–10.
1889:
1885:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1853:(6): 973–82.
1852:
1848:
1843:
1839:
1835:
1830:
1825:
1822:(3): 773–81.
1821:
1817:
1813:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1776:
1771:
1767:
1763:
1759:
1755:
1750:
1745:
1741:
1737:
1733:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1701:(9): 724–52.
1700:
1696:
1691:
1687:
1683:
1678:
1673:
1670:(2): 187–93.
1669:
1665:
1664:J. Endocrinol
1661:
1656:
1655:
1650:
1641:
1637:
1633:
1629:
1624:
1619:
1615:
1611:
1610:
1609:Endocrinology
1602:
1595:
1592:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1542:
1534:
1531:
1526:
1520:
1517:
1512:
1508:
1504:
1500:
1497:(4): 1701–2.
1496:
1492:
1491:Endocrinology
1485:
1482:
1477:
1473:
1467:
1464:
1459:
1455:
1449:
1446:
1442:
1438:
1433:
1431:
1429:
1425:
1421:
1417:
1412:
1410:
1408:
1404:
1397:
1395:
1393:
1389:
1381:
1379:
1376:
1368:
1366:
1364:
1360:
1357:
1353:
1349:
1345:
1333:
1328:
1324:
1320:
1317:
1313:
1306:
1304:
1301:
1297:
1293:
1289:
1286:
1282:
1278:
1271:
1269:
1263:
1259:
1256:
1250:
1248:
1244:
1238:
1234:
1231:
1227:
1220:
1218:
1212:
1208:
1205:
1199:
1197:
1191:
1187:
1184:
1182:RefSeq (mRNA)
1180:
1173:
1172:
1167:
1163:
1160:
1154:
1153:
1148:
1144:
1141:
1139:
1135:
1128:
1127:
1122:
1118:
1115:
1109:
1108:
1103:
1099:
1096:
1094:
1090:
1083:
1082:
1077:
1073:
1070:
1064:
1063:
1058:
1054:
1051:
1049:
1045:
1042:
1039:
1037:
1034:
1030:
1027:
1023:
1019:
1012:
1008:
1003:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
791:odontogenesis
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
743:
741:
738:
737:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
632:
631:Gene ontology
628:
624:
612:
607:
603:
596:
591:
588:
586:
582:
574:
569:
559:barrel cortex
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
521:
518:
514:
509:
506:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
459:
456:
452:
447:
444:
443:
440:
438:
434:
432:
431:
427:
426:
423:
421:
417:
413:
409:
405:
397:
392:
388:
384:
379:
369:
365:
358:
351:
345:
338:
330:
326:
322:
317:
313:
308:
304:
296:
291:
287:
283:
278:
268:
264:
257:
250:
244:
237:
233:
227:
223:
219:
214:
210:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
153:
148:
141:
136:
131:
120:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
4122:
4107:
4092:
4077:
4062:
4047:
4032:
3970:
3953:
3888:
3833:
3796:
3768:
3736:Antagonists:
3735:
3634:
3611:
3579:Antagonists:
3578:
3454:
3418:Antagonists:
3417:
3349:
3321:
3310:Lerdelimumab
3305:Fresolimumab
3301:
3263:
3217:
3199:Antagonists:
3198:
3170:
3132:
3048:
2965:
2954:Lerdelimumab
2949:Fresolimumab
2945:
2903:
2865:
2833:Antagonists:
2832:
2781:
2743:
2689:
2641:
2559:
2531:
2525:Dalantercept
2521:
2506:
2496:
2425:
2330:
2326:
2305:
2301:
2276:
2272:
2247:
2243:
2208:
2204:
2173:
2169:
2140:
2136:
2101:
2097:
2068:
2064:
2039:
2035:
1990:
1986:
1955:
1951:
1920:
1916:
1887:
1883:
1850:
1846:
1819:
1815:
1778:
1774:
1739:
1735:
1698:
1694:
1667:
1663:
1613:
1607:
1594:
1545:
1539:
1533:
1519:
1494:
1490:
1484:
1475:
1466:
1457:
1448:
1385:
1382:Interactions
1372:
1355:
1347:
1343:
1342:
1265:
1240:
1214:
1193:
1169:
1150:
1124:
1105:
1079:
1060:
1040:
1035:
555:aortic valve
523:cumulus cell
435:
428:
155:External IDs
74:
18:
4015:PDB gallery
3954:Antibodies:
3917:Follistatin
3772:Ramatercept
3615:Sotatercept
3315:Metelimumab
3302:Antibodies:
2959:Metelimumab
2946:Antibodies:
2535:Disitertide
2497:Antibodies:
1958:(1): 91–9.
1247:NP_002183.1
535:nasopharynx
394:16,206,206
381:16,186,436
293:41,705,834
280:41,667,168
133:Identifiers
3957:Stamulumab
3907:DAN (PARN)
3826:(β-glycan)
3729:Radotermin
3572:Radotermin
3552:11 (BMP11)
3508:15 (GDF9B)
3411:Radotermin
3276:10 (BMP3B)
3186:11 (BMP11)
3126:Radotermin
3084:15 (GDF9B)
2989:LY-2109761
2920:11 (BMP11)
2916:10 (BMP3B)
2815:11 (BMP11)
2394:modulators
2143:(1): 1–9.
1736:Stem Cells
1443:, May 2017
1422:, May 2017
1398:References
439:(ortholog)
176:HomoloGene
3837:Avotermin
3800:AMH (MIS)
3797:Agonists:
3708:7 (BMP12)
3704:6 (BMP13)
3700:5 (BMP14)
3635:Agonists:
3544:7 (BMP12)
3540:6 (BMP13)
3536:5 (BMP14)
3455:Agonists:
3405:7 (BMP12)
3401:6 (BMP13)
3397:5 (BMP14)
3350:Agonists:
3330:LY-364947
3267:Avotermin
3264:Agonists:
3231:SB-505124
3226:SB-431542
3171:Agonists:
3112:7 (BMP12)
3108:6 (BMP13)
3104:5 (BMP14)
3049:Agonists:
3019:SB-525334
3014:SB-505124
3009:SB-431542
2984:LY-364947
2979:GW-788388
2907:Avotermin
2904:Agonists:
2879:SB-505124
2874:SB-431542
2782:Agonists:
2693:AMH (MIS)
2690:Agonists:
2586:Avotermin
2581:AMH (MIS)
2560:Agonists:
2447:Avotermin
2426:Agonists:
2098:FEBS Lett
1632:0013-7227
1570:0028-0836
1268:NP_032406
1243:NP_002183
1217:NM_008380
1196:NM_002192
1026:Orthologs
485:beta cell
469:vena cava
184:GeneCards
4140:Category
3974:Endoglin
3882:Unsorted
3834:Ligands:
3814:Type III
3393:2 (BMP9)
2999:R-268712
2471:2 (BMP9)
2462:Cetermin
2302:Oncogene
2128:21261385
1952:Genomics
1875:36407277
1803:24201803
1795:15451571
1766:36242096
1758:12456957
1723:19795772
1715:12324653
1686:10320815
1578:10746731
1439:–
1418:–
1388:interact
1369:Function
1316:Wikidata
1005:Sources:
489:placenta
3971:Others:
3912:Decorin
3902:Chordin
3842:Inhibin
3739:Inhibin
3638:Activin
3582:Inhibin
3458:Activin
3421:Inhibin
3245:Type II
3221:A 83-01
3146:K-02288
2969:A 83-01
2869:A 83-01
2836:Inhibin
2785:Activin
2757:K-02288
2660:K-02288
2563:Activin
2510:K-02288
2429:Activin
2349:8955111
2314:8397373
2293:8267637
2264:8125298
2235:7615672
2227:8015550
2192:7890768
2157:7887917
2120:3758355
2085:3754442
2056:3345731
2027:3267209
1995:Bibcode
1974:2767687
1939:2575216
1904:1777673
1884:DNA Seq
1867:1646080
1838:1310063
1640:9202237
1586:4393629
1550:Bibcode
1511:3345731
1441:Ensembl
1420:Ensembl
1352:protein
1350:, is a
1138:UniProt
1093:Ensembl
1032:Species
1011:QuickGO
531:incisor
414:pattern
140:Aliases
3963:TRC105
3932:Noggin
3824:TGFβR3
3626:ACVR2B
3441:ACVR2A
3255:TGFβR2
3161:ACVR1C
3039:BMPR1B
3024:SD-208
2974:D-4476
2894:TGFβR1
2772:ACVR1B
2680:BMPR1A
2550:ACVR1A
2416:ACVRL1
2402:Type I
2347:
2312:
2291:
2262:
2233:
2225:
2190:
2155:
2126:
2118:
2083:
2054:
2025:
2018:280011
2015:
1972:
1937:
1902:
1873:
1865:
1836:
1801:
1793:
1764:
1756:
1721:
1713:
1684:
1638:
1630:
1584:
1576:
1568:
1541:Nature
1509:
1392:ACVR2A
1302:search
1300:PubMed
1171:Q04998
1152:P08476
1048:Entrez
585:BioGPS
272:7p14.1
164:147290
3927:LTBP1
3892:BAMBI
3783:AMHR2
3753:Lefty
3719:Nodal
3596:Lefty
3567:Nodal
3445:ACVR2
3341:BMPR2
3325:DMH-2
3202:Lefty
3192:Nodal
3136:DMH-2
2850:Lefty
2826:Nodal
2747:DMH-2
2650:DMH-2
2645:DMH-1
2231:S2CID
2124:S2CID
1871:S2CID
1816:Blood
1799:S2CID
1762:S2CID
1719:S2CID
1604:(PDF)
1582:S2CID
1390:with
1356:INHBA
1348:INHBA
1081:16323
1041:Mouse
1036:Human
1007:Amigo
437:Mouse
430:Human
377:Start
312:Mouse
276:Start
209:Human
188:INHBA
172:96570
147:INHBA
24:INHBA
4123:2p6a
4108:2b0u
4093:2arv
4078:2arp
4063:1s4y
4048:1nyu
4033:1nys
3937:TGIF
3856:TGFβ
3787:AMHR
3282:TGFβ
3157:ALK7
3035:ALK6
2926:TGFβ
2890:ALK5
2768:ALK4
2676:ALK3
2622:TGFβ
2546:ALK2
2477:TGFβ
2412:ALK1
2389:TGFβ
2345:PMID
2310:PMID
2289:PMID
2260:PMID
2244:Gene
2223:PMID
2188:PMID
2153:PMID
2116:PMID
2081:PMID
2052:PMID
2023:PMID
1970:PMID
1935:PMID
1900:PMID
1863:PMID
1847:Cell
1834:PMID
1791:PMID
1754:PMID
1711:PMID
1682:PMID
1636:PMID
1628:ISSN
1574:PMID
1566:ISSN
1507:PMID
1359:gene
1062:3624
420:Bgee
368:Band
329:Chr.
267:Band
226:Chr.
180:1653
160:OMIM
117:5HLZ
113:5HLY
109:4MID
105:3B4V
101:2P6A
97:2B0U
93:2ARV
89:2ARP
85:1S4Y
81:1NYU
77:1NYS
58:RCSB
55:PDBe
3688:GDF
3656:BMP
3524:GDF
3476:BMP
3389:GDF
3353:BMP
3272:GDF
3174:GDF
3100:GDF
3052:BMP
2912:GDF
2803:GDF
2698:BMP
2591:BMP
2467:GDF
2452:BMP
2335:doi
2331:271
2281:doi
2277:197
2252:doi
2248:138
2213:doi
2178:doi
2174:270
2145:doi
2141:208
2106:doi
2102:206
2073:doi
2069:135
2044:doi
2040:122
2013:PMC
2003:doi
1960:doi
1925:doi
1892:doi
1855:doi
1824:doi
1783:doi
1779:225
1744:doi
1703:doi
1699:227
1672:doi
1668:161
1618:doi
1614:138
1558:doi
1546:404
1499:doi
1495:122
1375:FSH
547:rib
390:End
289:End
192:OMA
168:MGI
48:PDB
4142::
3866:,
3862:,
3848:,
3759:,
3745:,
3706:,
3702:,
3698:,
3694:,
3670:,
3666:,
3662:,
3650:AB
3648:,
3644:,
3602:,
3588:,
3556:15
3554:,
3550:,
3546:,
3542:,
3538:,
3534:,
3530:,
3506:,
3504:8B
3502:,
3500:8A
3498:,
3494:,
3490:,
3486:,
3482:,
3470:AB
3468:,
3464:,
3427:,
3403:,
3399:,
3395:,
3373:10
3371:,
3367:,
3363:,
3359:,
3292:,
3288:,
3208:,
3184:,
3180:,
3120:15
3118:,
3114:,
3110:,
3106:,
3082:,
3080:8B
3078:,
3076:8A
3074:,
3070:,
3066:,
3062:,
3058:,
2936:,
2932:,
2918:,
2856:,
2842:,
2813:,
2809:,
2797:AB
2795:,
2791:,
2726:8B
2724:,
2722:8A
2720:,
2716:,
2712:,
2708:,
2704:,
2632:,
2628:,
2611:8B
2609:,
2607:8A
2605:,
2601:,
2597:,
2575:AB
2573:,
2569:,
2487:,
2483:,
2456:10
2441:AB
2439:,
2435:,
2343:.
2329:.
2325:.
2304:.
2287:.
2275:.
2258:.
2246:.
2229:.
2221:.
2207:.
2203:.
2186:.
2172:.
2168:.
2151:.
2139:.
2122:.
2114:.
2100:.
2096:.
2079:.
2067:.
2050:.
2038:.
2021:.
2011:.
2001:.
1991:85
1989:.
1985:.
1968:.
1954:.
1950:.
1933:.
1919:.
1915:.
1898:.
1886:.
1869:.
1861:.
1851:65
1849:.
1832:.
1820:79
1818:.
1814:.
1797:.
1789:.
1777:.
1760:.
1752:.
1740:20
1738:.
1734:.
1717:.
1709:.
1697:.
1680:.
1666:.
1662:.
1634:.
1626:.
1612:.
1606:.
1580:.
1572:.
1564:.
1556:.
1544:.
1505:.
1493:.
1474:.
1456:.
1427:^
1406:^
1394:.
1009:/
396:bp
383:bp
295:bp
282:bp
190:;
186::
182:;
178::
174:;
170::
166:;
162::
115:,
111:,
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
4008:e
4001:t
3994:v
3870:)
3868:3
3864:2
3860:1
3858:(
3852:)
3850:B
3846:A
3844:(
3789:)
3785:(
3763:)
3761:2
3757:1
3755:(
3749:)
3747:B
3743:A
3741:(
3710:)
3696:3
3692:1
3690:(
3674:)
3672:7
3668:6
3664:4
3660:2
3658:(
3652:)
3646:B
3642:A
3640:(
3606:)
3604:2
3600:1
3598:(
3592:)
3590:B
3586:A
3584:(
3558:)
3548:9
3532:3
3528:1
3526:(
3510:)
3496:7
3492:6
3488:5
3484:4
3480:2
3478:(
3472:)
3466:B
3462:A
3460:(
3447:)
3443:(
3431:)
3429:B
3425:A
3423:(
3407:)
3391:(
3375:)
3369:7
3365:6
3361:4
3357:2
3355:(
3296:)
3294:3
3290:2
3286:1
3284:(
3278:)
3274:(
3212:)
3210:2
3206:1
3204:(
3188:)
3182:3
3178:1
3176:(
3163:)
3159:(
3122:)
3116:9
3102:(
3086:)
3072:7
3068:6
3064:5
3060:4
3056:2
3054:(
3041:)
3037:(
2940:)
2938:3
2934:2
2930:1
2928:(
2922:)
2914:(
2896:)
2892:(
2860:)
2858:2
2854:1
2852:(
2846:)
2844:B
2840:A
2838:(
2817:)
2811:3
2807:1
2805:(
2799:)
2793:B
2789:A
2787:(
2774:)
2770:(
2728:)
2718:7
2714:6
2710:5
2706:4
2702:2
2700:(
2682:)
2678:(
2636:)
2634:3
2630:2
2626:1
2624:(
2613:)
2603:7
2599:6
2595:5
2593:(
2577:)
2571:B
2567:A
2565:(
2552:)
2548:(
2491:)
2489:3
2485:2
2481:1
2479:(
2473:)
2469:(
2458:)
2454:(
2443:)
2437:B
2433:A
2431:(
2418:)
2414:(
2380:e
2373:t
2366:v
2351:.
2337::
2316:.
2306:8
2295:.
2283::
2266:.
2254::
2237:.
2215::
2209:8
2194:.
2180::
2159:.
2147::
2130:.
2108::
2087:.
2075::
2058:.
2046::
2029:.
2005::
1997::
1976:.
1962::
1956:5
1941:.
1927::
1921:3
1906:.
1894::
1888:2
1877:.
1857::
1840:.
1826::
1805:.
1785::
1768:.
1746::
1725:.
1705::
1688:.
1674::
1642:.
1620::
1588:.
1560::
1552::
1527:.
1513:.
1501::
1478:.
1460:.
314:)
211:)
194::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
