361:
338:
235:
260:
2404:
2419:
4959:
2434:
2389:
612:
367:
266:
40:
66:
1964:
Bergh, JJ; Lin, HY; Lansing, L; Mohamed, SN; Davis, FB; Mousa, S; Davis, PJ (July 2005). "Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis".
2000:
Schmohl, KA; Han, Y; Tutter, M; Schwenk, N; Sarker, RSJ; Steiger, K; Ziegler, SI; Bartenstein, P; Nelson, PJ; Spitzweg, C (December 2020). "Integrin αvβ3-dependent thyroid hormone effects on tumour proliferation and vascularisation".
2036:
Waisberg J, De Souza VL, Affonso Junior RJ, Silva SR, Denadai MV, Margeotto FB, De Souza CS, Matos D (2014). "Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer".
1521:
ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the
Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
2113:Élez E, Kocáková I, Höhler T, Martens UM, Bokemeyer C, Van Cutsem E, Melichar B, Smakal M, Csőszi T, Topuzov E, Orlova R, Tjulandin S, Rivera F, Straub J, Bruns R, Quaratino S, Tabernero J (January 2015).
2115:"Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial"
2403:
3368:
2507:
2418:
2433:
1497:
heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8;
374:
273:
5000:
3358:
2388:
4939:
1917:"The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23"
1915:
Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, Caspary RG, Lindberg FP, Armitage R, Maliszewski C, Delespesse G, Sarfati M (February 1999).
3338:
1180:
196:
1161:
4200:
2524:
2500:
2469:
4806:
3931:
1851:"Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa"
3919:
3697:
3983:
3978:
3924:
3704:
2485:
2368:
1831:
1813:
5024:
5019:
3437:
3363:
2493:
63:
4993:
4544:
4466:
4461:
4456:
4451:
3378:
1849:
Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS (June 1988).
1404:
360:
4431:
1411:
337:
3667:
1898:
5034:
4235:
3729:
3415:
1800:
1779:
1493:
integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield
4986:
3874:
3410:
1796:
259:
234:
4371:
3843:
3838:
3783:
3517:
2966:
1775:
4065:
3788:
2188:
Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors".
176:
3383:
2476:
373:
272:
4095:
2520:
1751:
366:
265:
2961:
2361:
4145:
3040:
2463:
1225:
184:
4537:
4109:
1206:
4901:
4875:
4870:
4865:
4790:
4780:
4721:
3452:
3447:
3442:
3432:
2739:
2667:
4726:
2796:
2714:
2412:: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
4838:
4822:
4753:
4033:
3746:
2354:
1518:
248:
1679:
1555:
163:
4060:
3879:
1732:
1387:
1358:
1354:
1328:
1299:
1295:
5029:
4530:
3467:
3201:
2327:
2242:
2217:
Sajid M, Stouffer GA (February 2002). "The role of alpha(v)beta3 integrins in vascular healing".
208:
1383:
1362:
1324:
1303:
961:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
2314:
2285:
2234:
2205:
2176:
2136:
2095:
2046:
2018:
1982:
1946:
1899:"Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)"
1880:
1716:
156:
56:
4970:
4966:
4958:
4827:
4758:
4688:
4683:
4637:
4240:
3973:
3894:
3457:
2650:
2576:
2306:
2297:
Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments".
2275:
2267:
2226:
2197:
2168:
2126:
2085:
2077:
2010:
1974:
1936:
1928:
1870:
1862:
453:
384:
328:
283:
611:
204:
4300:
2836:
2831:
2754:
2480:
1720:
428:
2459:
4922:
4917:
4896:
4085:
3507:
3018:
2821:
2427:: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
2280:
2255:
2090:
2065:
1941:
1916:
1648:
1621:
1582:
2201:
2172:
1875:
1850:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
5013:
4055:
3512:
2603:
1490:
640:
2246:
4411:
3719:
3709:
3240:
3206:
2442:: A novel adaptation of the integrin PSI domain revealed from its crystal structure
446:
225:
188:
212:
4421:
4070:
3848:
3823:
3522:
3144:
3070:
2544:
1836:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1818:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1735:
1697:
1666:
1639:
1605:
1601:
1573:
529:
4351:
4075:
3756:
3497:
3373:
3006:
3001:
2996:
2851:
2635:
1739:
1715:
Overexpression of the ITGAV gene is associated with progression and spread of
345:
242:
192:
2310:
4190:
4185:
4180:
4170:
4165:
4160:
4155:
2159:
Horton MA (May 1997). "The alpha v beta 3 integrin "vitronectin receptor"".
2131:
2114:
1613:
1494:
1125:
589:
467:
412:
399:
311:
298:
200:
2473:
2318:
2289:
2271:
2238:
2230:
2140:
2099:
2081:
2050:
2022:
1986:
1950:
2209:
2180:
1932:
1884:
1451:
1446:
39:
4553:
4496:
4396:
4210:
4195:
3398:
3393:
3301:
2991:
1978:
1531:
1486:
1435:
1270:
1251:
2397:: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
2014:
4446:
4441:
4436:
4336:
4150:
4140:
3967:
3946:
3941:
3909:
3714:
3634:
3629:
3624:
3619:
3614:
3532:
3225:
3065:
3060:
3055:
3050:
3045:
2516:
1701:
1670:
1467:
1237:
1192:
1866:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
4731:
4617:
4612:
4386:
4346:
4331:
4315:
4310:
4290:
4285:
4220:
4028:
3998:
3962:
3953:
3766:
3734:
3598:
3593:
3563:
3542:
3502:
3462:
3328:
3306:
3265:
3189:
3184:
3179:
3174:
3169:
3164:
3033:
3028:
3023:
2971:
2956:
2826:
2816:
2779:
2774:
2692:
2687:
1419:
1147:
17:
2328:"Hope for transplant patients as study finds key to organ scarring"
986:
negative regulation of macrophage derived foam cell differentiation
4885:
4880:
4843:
4811:
4785:
4698:
4693:
4678:
4647:
4642:
4632:
4627:
4622:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4511:
4486:
4406:
4401:
4391:
4381:
4366:
4361:
4356:
4341:
4295:
4280:
4245:
4230:
4225:
4215:
4135:
4130:
4125:
4104:
4100:
4090:
4003:
3904:
3899:
3858:
3808:
3803:
3798:
3793:
3778:
3771:
3751:
3739:
3682:
3677:
3672:
3662:
3657:
3650:
3588:
3578:
3573:
3568:
3558:
3537:
3527:
3492:
3487:
3482:
3477:
3472:
3427:
3422:
3388:
3353:
3348:
3343:
3333:
3321:
3316:
3296:
3291:
3286:
3281:
3235:
3127:
3122:
2941:
2925:
2918:
2913:
2908:
2903:
2898:
2893:
2868:
2846:
2841:
2734:
2660:
2655:
2645:
1609:
1514:
1510:
1506:
1502:
1498:
1110:
1106:
4889:
4847:
4831:
4815:
4762:
4735:
4673:
4668:
4663:
4506:
4501:
4491:
4481:
4476:
4471:
4426:
4416:
4376:
4305:
4275:
4270:
4265:
4260:
4255:
4250:
4205:
4175:
4080:
4048:
4043:
4023:
4013:
4008:
3993:
3988:
3889:
3884:
3853:
3833:
3828:
3818:
3813:
3692:
3645:
3605:
3260:
3255:
3250:
3245:
3230:
3221:
3216:
3211:
3196:
3154:
3149:
3139:
3134:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3082:
3077:
3013:
2986:
2981:
2976:
2951:
2946:
2883:
2878:
2873:
2863:
2858:
2811:
2806:
2801:
2791:
2786:
2769:
2764:
2759:
2749:
2744:
2729:
2724:
2719:
2709:
2704:
2699:
2682:
2677:
2672:
2623:
2591:
2586:
2581:
2564:
2559:
2554:
2549:
1474:
180:
4526:
2489:
2350:
620:
4018:
2630:
2618:
2613:
2608:
2598:
2571:
2539:
2346:
946:
vascular endothelial growth factor receptor signaling pathway
4522:
2256:"The role of alpha(v)beta(3) in prostate cancer progression"
2161:
2066:"The role of alpha(v)beta(3) in prostate cancer progression"
991:
negative regulation of extrinsic apoptotic signaling pathway
1061:
positive regulation of cytosolic calcium ion concentration
1016:
extrinsic apoptotic signaling pathway in absence of ligand
1742:
target this protein which is found on some tumour cells.
1096:
regulation of transforming growth factor beta activation
971:
negative regulation of entry of bacterium into host cell
436:
4974:
601:
1663:
proliferating epithelia, esp. lung and mammary gland
1066:
positive regulation of cell population proliferation
1006:
negative regulation of lipoprotein metabolic process
4910:
4858:
4799:
4773:
4746:
4714:
4707:
4656:
4560:
4324:
4118:
3867:
3551:
3274:
2934:
2532:
1598:
activated endothelial cells, melanoma, glioblastoma
1376:
1347:
1317:
1288:
1792:
1790:
1788:
1771:
1769:
1767:
167:, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V
383:
282:
1036:positive regulation of osteoblast proliferation
1910:
1908:
1797:GRCm38: Ensembl release 89: ENSMUSG00000027087
1636:widespread, esp. fibroblasts, epithelial cells
4994:
4538:
2501:
2362:
906:apolipoprotein A-I-mediated signaling pathway
8:
1776:GRCh38: Ensembl release 89: ENSG00000138448
941:substrate adhesion-dependent cell spreading
5001:
4987:
4711:
4545:
4531:
4523:
2508:
2494:
2486:
2369:
2355:
2347:
1121:
636:
424:
323:
220:
74:
2525:list of human clusters of differentiation
2462:at the U.S. National Library of Medicine
2279:
2130:
2089:
1940:
1874:
775:alphav-beta3 integrin-IGF-1-IGF1R complex
1536:
2384:
1763:
654:transforming growth factor beta binding
27:Mammalian protein found in Homo sapiens
2254:Cooper CR, Chay CH, Pienta KJ (2002).
2064:Cooper CR, Chay CH, Pienta KJ (2002).
1011:negative regulation of lipid transport
936:regulation of apoptotic cell clearance
870:alphav-beta3 integrin-PKCalpha complex
664:voltage-gated calcium channel activity
29:
1855:The Journal of Clinical Investigation
931:positive regulation of cell migration
835:integral component of plasma membrane
388:
349:
344:
287:
246:
241:
7:
4955:
4953:
1021:positive regulation of cell adhesion
916:negative regulation of lipid storage
704:insulin-like growth factor I binding
684:extracellular matrix protein binding
1081:positive regulation of MAPK cascade
981:calcium ion transmembrane transport
976:integrin-mediated signaling pathway
875:alphav-beta3 integrin-HMGB1 complex
4973:. You can help Knowledge (XXG) by
4940:cell surface receptor deficiencies
1373:
1344:
1314:
1285:
1261:
1242:
1216:
1197:
1171:
1152:
1086:cell adhesion mediated by integrin
606:
524:
462:
441:
25:
1470:that in humans is encoded by the
921:extracellular matrix organization
4957:
2432:
2417:
2402:
2387:
2326:University of Edinburgh (2013).
1534:that include alpha-V are :
1056:cellular calcium ion homeostasis
820:external side of plasma membrane
714:fibroblast growth factor binding
610:
372:
365:
359:
336:
271:
264:
258:
233:
38:
1694:neural tissue; peripheral nerve
901:endodermal cell differentiation
926:heterotypic cell-cell adhesion
780:integral component of membrane
621:More reference expression data
590:More reference expression data
1:
2202:10.1016/S0962-8924(98)01344-0
2173:10.1016/S1357-2725(96)00155-0
1489:alpha chain V. Integrins are
865:integrin alphav-beta6 complex
795:integrin alphav-beta8 complex
785:integrin alphav-beta5 complex
765:integrin alphav-beta3 complex
357:
256:
4800:Leukocyte-adhesion receptor:
689:extracellular matrix binding
482:Epithelium of choroid plexus
5025:Clusters of differentiation
5020:Genes on human chromosome 2
4859:Very late antigen receptor:
2521:clusters of differentiation
2299:Current Medicinal Chemistry
1921:The Journal of Cell Biology
1604:, fibronectin, fibrinogen,
5051:
4952:
2219:Thrombosis and Haemostasis
1752:Cluster of differentiation
1517:), each can interact with
1091:viral entry into host cell
891:regulation of phagocytosis
734:signaling receptor binding
544:retinal pigment epithelium
478:retinal pigment epithelium
4935:
2382:
1832:"Mouse PubMed Reference:"
1814:"Human PubMed Reference:"
1450:
1445:
1441:
1434:
1418:
1405:Chr 2: 186.59 – 186.68 Mb
1399:
1380:
1351:
1340:
1321:
1292:
1281:
1268:
1264:
1249:
1245:
1236:
1223:
1219:
1204:
1200:
1191:
1178:
1174:
1159:
1155:
1146:
1131:
1124:
1120:
1104:
860:specific granule membrane
639:
635:
618:
609:
600:
587:
536:
527:
474:
465:
435:
427:
423:
406:
393:
356:
335:
326:
322:
305:
292:
255:
232:
223:
219:
174:
171:
161:
154:
149:
82:
77:
60:
55:
50:
46:
37:
32:
2464:Medical Subject Headings
2311:10.2174/0929867053363522
2003:Endocrine-related Cancer
1076:neutrophil degranulation
966:blood vessel development
896:apoptotic cell clearance
729:C-X3-C chemokine binding
674:protein kinase C binding
2472:Info with links in the
1526:Alpha V class integrins
1412:Chr 2: 83.55 – 83.64 Mb
1001:cell-substrate adhesion
669:virus receptor activity
576:external carotid artery
5035:Membrane protein stubs
4969:–related article is a
2474:Cell Migration Gateway
2272:10.1038/sj.neo.7900224
2231:10.1055/s-0037-1612971
2190:Trends in Cell Biology
2082:10.1038/sj.neo.7900224
760:lamellipodium membrane
510:metanephric glomerulus
4911:Vitronectin receptor:
4774:Fibronectin receptor:
4727:Glycoprotein IIb/IIIa
4715:Cytoadhesin receptor:
2132:10.1093/annonc/mdu474
1933:10.1083/jcb.144.4.767
1711:Clinical significance
1026:ERK1 and ERK2 cascade
770:extracellular exosome
4902:Integrin alpha6beta1
4876:Integrin alpha3beta1
4871:Integrin alpha2beta1
4866:Integrin alpha1beta1
4839:Integrin alphaXbeta2
4823:Macrophage-1 antigen
4791:Integrin alpha5beta1
4786:Integrin alpha4beta1
4781:Integrin alpha2beta1
4754:Macrophage-1 antigen
4747:Fibrinogen receptor:
4722:Integrin alpha6beta4
1979:10.1210/en.2005-0102
1595:vitronectin receptor
1519:extracellular matrix
951:cell-matrix adhesion
810:microvillus membrane
351:Chromosome 2 (mouse)
249:Chromosome 2 (human)
78:List of PDB id codes
51:Available structures
2015:10.1530/ERC-20-0353
1570:neurological tumors
996:leukocyte migration
911:negative chemotaxis
815:filopodium membrane
724:coreceptor activity
694:fibronectin binding
552:conjunctival fornix
486:germinal epithelium
390:2 D|2 49.33 cM
2479:2014-12-11 at the
2119:Annals of Oncology
1226:ENSMUSG00000027087
884:Biological process
825:phagocytic vesicle
753:Cellular component
719:neuregulin binding
647:Molecular function
564:epithelium of lens
4982:
4981:
4947:
4946:
4931:
4930:
4520:
4519:
2450:
2449:
1867:10.1172/JCI113548
1717:colorectal cancer
1708:
1707:
1461:
1460:
1457:
1456:
1430:
1429:
1395:
1394:
1370:
1369:
1336:
1335:
1311:
1310:
1277:
1276:
1258:
1257:
1232:
1231:
1213:
1212:
1187:
1186:
1168:
1167:
1116:
1115:
659:metal ion binding
631:
630:
627:
626:
596:
595:
583:
582:
521:
520:
419:
418:
318:
317:
213:ITGAV - orthologs
145:
144:
141:
140:
61:Ortholog search:
16:(Redirected from
5042:
5003:
4996:
4989:
4967:membrane protein
4961:
4954:
4712:
4547:
4540:
4533:
4524:
2510:
2503:
2496:
2487:
2436:
2421:
2406:
2391:
2371:
2364:
2357:
2348:
2342:
2340:
2338:
2322:
2293:
2283:
2250:
2213:
2184:
2145:
2144:
2134:
2110:
2104:
2103:
2093:
2061:
2055:
2054:
2045:(10): 5599–607.
2033:
2027:
2026:
1997:
1991:
1990:
1961:
1955:
1954:
1944:
1912:
1903:
1902:
1895:
1889:
1888:
1878:
1846:
1840:
1839:
1828:
1822:
1821:
1810:
1804:
1794:
1783:
1773:
1727:As a drug target
1537:
1495:disulfide-linked
1464:Integrin alpha-V
1443:
1442:
1414:
1407:
1390:
1374:
1365:
1345:
1341:RefSeq (protein)
1331:
1315:
1306:
1286:
1262:
1243:
1217:
1198:
1172:
1153:
1122:
805:integrin complex
744:integrin binding
679:protease binding
637:
623:
614:
607:
592:
532:
530:Top expressed in
525:
470:
468:Top expressed in
463:
442:
425:
415:
402:
391:
376:
369:
363:
352:
340:
324:
314:
301:
290:
275:
268:
262:
251:
237:
221:
215:
166:
159:
136:
75:
69:
48:
47:
42:
30:
21:
5050:
5049:
5045:
5044:
5043:
5041:
5040:
5039:
5010:
5009:
5008:
5007:
4950:
4948:
4943:
4927:
4906:
4854:
4795:
4769:
4742:
4703:
4652:
4556:
4551:
4521:
4516:
4320:
4114:
3863:
3547:
3270:
2930:
2528:
2514:
2481:Wayback Machine
2456:
2451:
2446:
2443:
2437:
2428:
2422:
2413:
2407:
2398:
2392:
2378:
2375:
2345:
2336:
2334:
2325:
2296:
2253:
2216:
2187:
2158:
2154:
2152:Further reading
2149:
2148:
2112:
2111:
2107:
2063:
2062:
2058:
2035:
2034:
2030:
2009:(12): 685–697.
1999:
1998:
1994:
1963:
1962:
1958:
1914:
1913:
1906:
1897:
1896:
1892:
1848:
1847:
1843:
1830:
1829:
1825:
1812:
1811:
1807:
1795:
1786:
1774:
1765:
1760:
1748:
1729:
1721:prostate cancer
1713:
1687:
1683:
1656:
1652:
1642:and adenovirus
1629:
1625:
1590:
1586:
1563:
1559:
1530:In mammals the
1528:
1483:
1452:View/Edit Mouse
1447:View/Edit Human
1410:
1403:
1400:Location (UCSC)
1386:
1382:
1361:
1357:
1353:
1327:
1323:
1302:
1298:
1294:
1207:ENSG00000138448
1100:
879:
830:plasma membrane
800:ruffle membrane
748:
739:peptide binding
709:protein binding
699:opsonin binding
619:
588:
579:
574:
570:
566:
562:
558:
554:
550:
548:renal corpuscle
546:
542:
528:
517:
514:parietal pleura
512:
508:
504:
502:visceral pleura
500:
496:
494:right ventricle
492:
488:
484:
480:
466:
410:
397:
389:
379:
378:
377:
370:
350:
327:Gene location (
309:
296:
288:
278:
277:
276:
269:
247:
224:Gene location (
175:
162:
155:
84:
62:
28:
23:
22:
15:
12:
11:
5:
5048:
5046:
5038:
5037:
5032:
5027:
5022:
5012:
5011:
5006:
5005:
4998:
4991:
4983:
4980:
4979:
4962:
4945:
4944:
4936:
4933:
4932:
4929:
4928:
4926:
4925:
4923:Alpha-v beta-5
4920:
4918:Alpha-v beta-3
4914:
4912:
4908:
4907:
4905:
4904:
4899:
4897:Alpha-5 beta-1
4894:
4893:
4892:
4878:
4873:
4868:
4862:
4860:
4856:
4855:
4853:
4852:
4851:
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4836:
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4834:
4820:
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3214:
3209:
3204:
3199:
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3187:
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3177:
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3167:
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3147:
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3137:
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3110:
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3016:
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3009:
3004:
2999:
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2515:
2513:
2512:
2505:
2498:
2490:
2484:
2483:
2467:
2455:
2454:External links
2452:
2448:
2447:
2445:
2444:
2438:
2431:
2429:
2423:
2416:
2414:
2408:
2401:
2399:
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2323:
2294:
2251:
2214:
2185:
2155:
2153:
2150:
2147:
2146:
2105:
2056:
2039:Anticancer Res
2028:
1992:
1973:(7): 2864–71.
1956:
1904:
1890:
1841:
1823:
1805:
1784:
1762:
1761:
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1568:
1566:
1561:
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1544:
1541:
1527:
1524:
1485:ITGAV encodes
1482:
1479:
1459:
1458:
1455:
1454:
1449:
1439:
1438:
1432:
1431:
1428:
1427:
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1247:
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1240:
1234:
1233:
1230:
1229:
1221:
1220:
1214:
1211:
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1195:
1189:
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1144:
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1138:
1133:
1129:
1128:
1118:
1117:
1114:
1113:
1102:
1101:
1099:
1098:
1093:
1088:
1083:
1078:
1073:
1071:cell migration
1068:
1063:
1058:
1053:
1051:vasculogenesis
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
887:
885:
881:
880:
878:
877:
872:
867:
862:
857:
852:
850:focal adhesion
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
756:
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750:
749:
747:
746:
741:
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721:
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686:
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629:
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569:
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541:
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522:
519:
518:
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515:
511:
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499:
495:
491:
487:
483:
479:
475:
472:
471:
459:
458:
450:
439:
433:
432:
429:RNA expression
421:
420:
417:
416:
408:
404:
403:
395:
392:
387:
381:
380:
371:
364:
358:
354:
353:
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341:
333:
332:
320:
319:
316:
315:
307:
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294:
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173:
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139:
138:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5047:
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3873:
3872:
3870:
3866:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3773:
3770:
3768:
3765:
3764:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3741:
3738:
3736:
3733:
3731:
3728:
3727:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3699:
3696:
3694:
3691:
3690:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3652:
3649:
3647:
3644:
3643:
3642:
3639:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3612:
3609:
3607:
3604:
3600:
3597:
3595:
3592:
3590:
3587:
3586:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3556:
3554:
3550:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3417:
3414:
3412:
3409:
3408:
3407:
3404:
3400:
3397:
3395:
3392:
3391:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3323:
3320:
3318:
3315:
3314:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3279:
3277:
3273:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3162:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3129:
3126:
3124:
3121:
3120:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3043:
3042:
3039:
3035:
3032:
3030:
3027:
3025:
3022:
3021:
3020:
3017:
3015:
3012:
3008:
3005:
3003:
3000:
2998:
2995:
2994:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2939:
2937:
2933:
2927:
2924:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2891:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2853:
2850:
2848:
2845:
2843:
2840:
2838:
2835:
2834:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2781:
2778:
2776:
2773:
2772:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2694:
2691:
2689:
2686:
2685:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2643:
2642:
2639:
2637:
2634:
2632:
2629:
2625:
2622:
2621:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2593:
2590:
2588:
2585:
2583:
2580:
2579:
2578:
2575:
2573:
2570:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2542:
2541:
2538:
2537:
2535:
2531:
2526:
2522:
2518:
2511:
2506:
2504:
2499:
2497:
2492:
2491:
2488:
2482:
2478:
2475:
2471:
2468:
2465:
2461:
2458:
2457:
2453:
2441:
2435:
2430:
2426:
2420:
2415:
2411:
2405:
2400:
2396:
2390:
2385:
2381:
2372:
2367:
2365:
2360:
2358:
2353:
2352:
2349:
2333:
2329:
2324:
2320:
2316:
2312:
2308:
2304:
2300:
2295:
2291:
2287:
2282:
2277:
2273:
2269:
2265:
2261:
2257:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2225:(2): 187–93.
2224:
2220:
2215:
2211:
2207:
2203:
2199:
2196:(10): 390–6.
2195:
2191:
2186:
2182:
2178:
2174:
2170:
2166:
2162:
2157:
2156:
2151:
2142:
2138:
2133:
2128:
2125:(1): 132–40.
2124:
2120:
2116:
2109:
2106:
2101:
2097:
2092:
2087:
2083:
2079:
2075:
2071:
2067:
2060:
2057:
2052:
2048:
2044:
2040:
2032:
2029:
2024:
2020:
2016:
2012:
2008:
2004:
1996:
1993:
1988:
1984:
1980:
1976:
1972:
1968:
1967:Endocrinology
1960:
1957:
1952:
1948:
1943:
1938:
1934:
1930:
1927:(4): 767–75.
1926:
1922:
1918:
1911:
1909:
1905:
1900:
1894:
1891:
1886:
1882:
1877:
1872:
1868:
1864:
1861:(6): 1993–8.
1860:
1856:
1852:
1845:
1842:
1837:
1833:
1827:
1824:
1819:
1815:
1809:
1806:
1802:
1798:
1793:
1791:
1789:
1785:
1781:
1777:
1772:
1770:
1768:
1764:
1757:
1753:
1750:
1749:
1745:
1743:
1741:
1737:
1734:
1726:
1724:
1722:
1718:
1710:
1703:
1699:
1696:
1693:
1691:
1689:
1688:
1677:
1676:
1672:
1668:
1665:
1662:
1660:
1658:
1657:
1646:
1645:
1641:
1638:
1635:
1633:
1631:
1630:
1619:
1618:
1615:
1611:
1607:
1603:
1600:
1597:
1594:
1592:
1591:
1580:
1579:
1576:; fibrinogen
1575:
1572:
1569:
1567:
1565:
1564:
1553:
1552:
1548:
1545:
1542:
1539:
1538:
1535:
1533:
1525:
1523:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1491:heterodimeric
1488:
1480:
1478:
1476:
1473:
1469:
1465:
1453:
1448:
1444:
1440:
1437:
1433:
1426:
1424:
1421:
1417:
1413:
1409:
1406:
1402:
1398:
1391:
1389:
1385:
1379:
1375:
1372:
1366:
1364:
1360:
1356:
1350:
1346:
1343:
1339:
1332:
1330:
1326:
1320:
1316:
1313:
1307:
1305:
1301:
1297:
1291:
1287:
1284:
1282:RefSeq (mRNA)
1280:
1273:
1272:
1267:
1263:
1260:
1254:
1253:
1248:
1244:
1241:
1239:
1235:
1228:
1227:
1222:
1218:
1215:
1209:
1208:
1203:
1199:
1196:
1194:
1190:
1183:
1182:
1177:
1173:
1170:
1164:
1163:
1158:
1154:
1151:
1149:
1145:
1142:
1139:
1137:
1134:
1130:
1127:
1123:
1119:
1112:
1108:
1103:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1041:cell adhesion
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
956:viral process
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
888:
886:
883:
882:
876:
873:
871:
868:
866:
863:
861:
858:
856:
855:cell junction
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
757:
755:
752:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
651:
649:
646:
645:
642:
641:Gene ontology
638:
634:
622:
617:
613:
608:
605:
603:
599:
591:
586:
575:
571:
568:body of femur
567:
563:
559:
555:
551:
547:
543:
539:
538:
535:
531:
526:
523:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
476:
473:
469:
464:
461:
460:
457:
455:
451:
449:
448:
444:
443:
440:
438:
434:
430:
426:
422:
414:
409:
405:
401:
396:
386:
382:
375:
368:
362:
355:
347:
343:
339:
334:
330:
325:
321:
313:
308:
304:
300:
295:
285:
281:
274:
267:
261:
254:
250:
244:
240:
236:
231:
227:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
170:
165:
158:
153:
148:
137:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
4975:expanding it
4964:
4949:
4937:
4038:
3958:
3936:
3914:
3761:
3724:
3687:
3640:
3610:
3583:
3405:
3311:
3159:
2888:
2640:
2460:CD51+Antigen
2439:
2424:
2409:
2394:
2335:. Retrieved
2332:ScienceDaily
2331:
2305:(1): 51–70.
2302:
2298:
2266:(3): 191–4.
2263:
2259:
2222:
2218:
2193:
2189:
2167:(5): 721–5.
2164:
2160:
2122:
2118:
2108:
2076:(3): 191–4.
2073:
2069:
2059:
2042:
2038:
2031:
2006:
2002:
1995:
1970:
1966:
1959:
1924:
1920:
1893:
1858:
1854:
1844:
1835:
1826:
1817:
1808:
1730:
1714:
1678:
1647:
1620:
1581:
1554:
1546:Distribution
1529:
1484:
1471:
1463:
1462:
1388:NP_001385620
1381:
1359:NP_001138472
1355:NP_001138471
1352:
1329:NM_001398691
1322:
1300:NM_001145000
1296:NM_001144999
1293:
1269:
1250:
1224:
1205:
1179:
1160:
1140:
1135:
1046:angiogenesis
840:cell surface
540:cumulus cell
452:
445:
310:186,680,901
297:186,590,056
172:External IDs
83:
2377:PDB gallery
2337:December 2,
1736:intetumumab
1698:fibronectin
1667:fibronectin
1640:vitronectin
1606:osteopontin
1602:vitronectin
1574:vitronectin
1031:cell growth
498:skin of hip
411:83,637,260
398:83,554,741
150:Identifiers
5014:Categories
2523:(see also
1803:, May 2017
1782:, May 2017
1758:References
1740:abituzumab
506:glomerulus
456:(ortholog)
193:HomoloGene
5030:Integrins
4938:see also
4554:Integrins
2260:Neoplasia
2070:Neoplasia
1614:thyroxine
1532:integrins
1384:NP_032428
1363:NP_002201
1325:NM_008402
1304:NM_002210
1126:Orthologs
201:GeneCards
2517:Proteins
2477:Archived
2319:15638730
2290:11988838
2247:76995133
2239:11858476
2141:25319061
2100:11988838
2051:25275062
2023:33112795
1987:15802494
1951:10037797
1799:–
1778:–
1746:See also
1549:Ligands
1543:Synonyms
1487:integrin
1481:Function
1436:Wikidata
1105:Sources:
790:membrane
572:gastrula
560:calvaria
4325:301–350
4119:251–300
4071:CD240CE
3868:201–250
3552:151–200
3275:101–150
2281:1531692
2210:9789327
2181:9251239
2091:1531692
1942:2132927
1885:2454952
1801:Ensembl
1780:Ensembl
1468:protein
1238:UniProt
1193:Ensembl
1132:Species
1111:QuickGO
845:cytosol
556:decidua
431:pattern
157:Aliases
4732:ITGA2B
4708:Dimers
4332:CD300A
4291:CDw293
4076:CD240D
3937:CD213a
3915:CDw210
3880:CD202b
3854:CDw199
3849:CDw198
3503:CD140b
2935:51–100
2466:(MeSH)
2317:
2288:
2278:
2245:
2237:
2208:
2179:
2139:
2098:
2088:
2049:
2021:
1985:
1949:
1939:
1883:
1876:442653
1873:
1738:, and
1719:, and
1513:, and
1422:search
1420:PubMed
1271:P43406
1252:P06756
1148:Entrez
602:BioGPS
289:2q32.1
181:193210
4965:This
4886:CD49d
4881:VLA-4
4844:CD11c
4828:CD11b
4812:CD11a
4807:LFA-1
4759:CD11b
4736:ITGB3
4561:Alpha
4512:CD350
4507:CD349
4502:CD344
4497:CD340
4492:CD339
4487:CD338
4482:CD337
4477:CD336
4472:CD335
4467:CD334
4462:CD333
4457:CD332
4452:CD331
4447:CD329
4442:CD328
4437:CD327
4432:CD326
4427:CD325
4422:CD324
4417:CD322
4412:CD321
4407:CD320
4402:CD318
4397:CD317
4392:CD316
4387:CD315
4382:CD314
4377:CD312
4372:CD309
4367:CD307
4362:CD306
4357:CD305
4352:CD304
4347:CD303
4342:CD302
4337:CD301
4316:CD299
4311:CD298
4306:CD297
4301:CD295
4296:CD294
4286:CD292
4281:CD290
4276:CD289
4271:CD288
4266:CD286
4261:CD284
4256:CD283
4251:CD282
4246:CD281
4241:CD280
4236:CD279
4231:CD278
4226:CD276
4221:CD275
4216:CD274
4211:CD273
4206:CD272
4201:CD271
4196:CD269
4191:CD268
4186:CD267
4181:CD266
4176:CD265
4171:CD264
4166:CD263
4161:CD262
4156:CD261
4151:CD258
4146:CD257
4141:CD256
4136:CD254
4131:CD253
4126:CD252
4110:CD249
4105:CD248
4101:CD247
4096:CD246
4091:CD244
4086:CD243
4081:CD241
4066:CD239
4061:CD238
4056:CD236
4039:CD235
4034:CD234
4029:CD233
4024:CD230
4019:CD229
4014:CD228
4009:CD227
4004:CD226
3999:CD225
3994:CD224
3989:CD223
3984:CD222
3979:CD221
3974:CD220
3959:CD218
3954:CD217
3932:CD212
3910:CD209
3905:CD208
3900:CD207
3895:CD206
3890:CD205
3885:CD204
3875:CD201
3859:CD200
3844:CD197
3839:CD196
3834:CD195
3829:CD194
3824:CD193
3819:CD192
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3804:CD185
3799:CD184
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3683:CD166
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3433:CD124
3428:CD123
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3406:CD121
3389:CD120
3384:CD119
3379:CD118
3374:CD117
3369:CD116
3364:CD115
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3354:CD113
3349:CD112
3344:CD111
3339:CD110
3334:CD109
3329:CD108
3312:CD107
3307:CD106
3302:CD105
3297:CD104
3292:CD103
3287:CD102
3282:CD101
3266:CD100
2470:ITGAV
2243:S2CID
1610:Cyr61
1515:ITGB8
1511:ITGB6
1507:ITGB5
1503:ITGB3
1499:ITGB1
1472:ITGAV
1466:is a
1181:16410
1141:Mouse
1136:Human
1107:Amigo
490:tibia
454:Mouse
447:Human
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329:Mouse
293:Start
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189:96608
164:ITGAV
33:ITGAV
18:ITGAV
4971:stub
4890:CD29
4848:CD18
4832:CD18
4816:CD18
4763:CD18
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3261:CD99
3256:CD98
3251:CD97
3246:CD96
3241:CD95
3236:CD94
3231:CD93
3226:CD92
3222:CD91
3217:CD90
3212:CD89
3207:CD88
3202:CD87
3197:CD86
3160:CD85
3155:CD84
3150:CD83
3145:CD82
3140:CD81
3135:CD80
3118:CD79
3113:CD78
3108:CD74
3103:CD73
3098:CD72
3093:CD71
3088:CD70
3083:CD69
3078:CD68
3041:CD66
3019:CD64
3014:CD63
2992:CD62
2987:CD61
2982:CD59
2977:CD58
2972:CD57
2967:CD56
2962:CD55
2957:CD54
2952:CD53
2947:CD52
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2864:CD44
2859:CD43
2832:CD42
2827:CD41
2822:CD40
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2812:CD38
2807:CD37
2802:CD36
2797:CD35
2792:CD34
2787:CD33
2770:CD32
2765:CD31
2760:CD30
2755:CD29
2750:CD28
2745:CD27
2740:CD26
2735:CD25
2730:CD24
2725:CD23
2720:CD22
2715:CD21
2710:CD20
2705:CD19
2700:CD18
2683:CD16
2678:CD15
2673:CD14
2668:CD13
2641:CD11
2636:CD10
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2440:1u8c
2425:1m1x
2410:1l5g
2395:1jv2
2339:2014
2315:PMID
2286:PMID
2235:PMID
2206:PMID
2177:PMID
2137:PMID
2096:PMID
2047:PMID
2019:PMID
1983:PMID
1947:PMID
1881:PMID
1733:mAbs
1731:The
1704:1+3
1702:TGFβ
1673:1+3
1671:TGFβ
1540:Name
1475:gene
1162:3685
437:Bgee
385:Band
346:Chr.
284:Band
243:Chr.
177:OMIM
134:4UM9
130:4UM8
126:4O02
122:4MMZ
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106:4G1E
102:3IJE
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64:PDBe
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2631:CD9
2619:CD8
2614:CD7
2609:CD6
2604:CD5
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2307:doi
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2268:doi
2227:doi
2198:doi
2169:doi
2127:doi
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2078:doi
2011:doi
1975:doi
1971:146
1937:PMC
1929:doi
1925:144
1871:PMC
1863:doi
407:End
306:End
209:OMA
185:MGI
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4689:B6
4684:B5
4679:B4
4674:B3
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